nsc-614846 has been researched along with 2--3--dideoxythymidine-triphosphate* in 1 studies
1 other study(ies) available for nsc-614846 and 2--3--dideoxythymidine-triphosphate
| Article | Year |
|---|---|
Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases.
Carbocylic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir; NSC 614846) is an antiretroviral agent which may be useful in the treatment of AIDS. We have synthesized the 5'-triphosphate of Carbovir and examined its ability to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (EC 2.7.7.49) and other retroviral reverse transcriptases, as well as human DNA polymerases alpha, beta, gamma (EC 2.7.7.7) and DNA primase (EC 2.7.7.6). Carbovir triphosphate emerges as a highly selective inhibitor of reverse transcriptases with little, if any, effect on the cellular enzymes. 3'-Azido-2',3'-dideoxythymidine (AZT) triphosphate and the two dideoxynucleoside triphosphates, ddTTP and ddGTP, inhibited HIV-1 reverse transcriptase to the same degree as Carbovir triphosphate, but were less selective in that they also inhibited DNA polymerases beta and gamma. We conclude that Carbovir is a highly selective antiretroviral agent. Topics: Deoxyguanine Nucleotides; Dideoxynucleosides; Dideoxynucleotides; DNA Primase; HIV; Humans; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; RNA Nucleotidyltransferases; Thymine Nucleotides; Zidovudine | 1989 |