nsc-259-968 and isodityrosine

nsc-259-968 has been researched along with isodityrosine* in 1 studies

Other Studies

1 other study(ies) available for nsc-259-968 and isodityrosine

Article	Year
Aza-cycloisodityrosine analogue of RA-VII, an antitumor bicyclic hexapeptide. Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24 An aza-cycloisodityrosine analogue of RA-VII, 3, was designed and synthesized. The key aza-cycloisodityrosine unit was prepared by copper(II)-acetate-mediated intramolecular phenylamine/arylboronic acid coupling of dipeptide followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with EDC · HCl and HOOBt under dilute conditions gave 3. Analogue 3 showed significant cytotoxic activity against human promyelocytic leukemia HL-60 cells and human colon carcinoma HCT-116 cells, but its activity was weaker than that of parent peptide RA-VII (1). Topics: Antineoplastic Agents, Phytogenic; Aza Compounds; Crystallography, X-Ray; HCT116 Cells; HL-60 Cells; Humans; Molecular Conformation; Peptides; Peptides, Cyclic; Rubia; Tyrosine	2013

Article

Year

Aza-cycloisodityrosine analogue of RA-VII, an antitumor bicyclic hexapeptide.

Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24

An aza-cycloisodityrosine analogue of RA-VII, 3, was designed and synthesized. The key aza-cycloisodityrosine unit was prepared by copper(II)-acetate-mediated intramolecular phenylamine/arylboronic acid coupling of dipeptide followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with EDC · HCl and HOOBt under dilute conditions gave 3. Analogue 3 showed significant cytotoxic activity against human promyelocytic leukemia HL-60 cells and human colon carcinoma HCT-116 cells, but its activity was weaker than that of parent peptide RA-VII (1).

Topics: Antineoplastic Agents, Phytogenic; Aza Compounds; Crystallography, X-Ray; HCT116 Cells; HL-60 Cells; Humans; Molecular Conformation; Peptides; Peptides, Cyclic; Rubia; Tyrosine

2013