ns-220 and muraglitazar

ns-220 has been researched along with muraglitazar* in 1 studies

Other Studies

1 other study(ies) available for ns-220 and muraglitazar

Article	Year
Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety. Bioorganic & medicinal chemistry letters, 2008, Dec-15, Volume: 18, Issue:24 Oxazole containing glycine and oximinobutyric acid derivatives were synthesized as PPARalpha agonists by incorporating polymethylene spacer as a replacement of commonly used phenylene group that connects the acidic head with lipophilic tail. Compound 13a was found to be a selective and potent PPARalpha agonist. Further 1,3-dioxane-2-carboxylic acid derivative 20 was synthesized by replacing the tetramethylene spacer of NS-220, a selective PPARalpha agonist with phenylene group and found to exhibit PPARalpha/gamma dual agonism. These results suggest that compounds possessing polymethylene spacer between pharmacophore and lipophilic tail exhibit predominantly PPARalpha agonism whereas those with an aromatic phenylene spacer shows PPARalpha/gamma dual agonism. Topics: Butyrates; Chemistry, Pharmaceutical; Dioxanes; Drug Design; Glycine; Humans; Hydrogen; Hydrogen Bonding; Ligands; Models, Chemical; Oxazoles; Peroxisome Proliferator-Activated Receptors; PPAR alpha; Transcriptional Activation	2008

Article

Year

Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety.

Bioorganic & medicinal chemistry letters, 2008, Dec-15, Volume: 18, Issue:24

Oxazole containing glycine and oximinobutyric acid derivatives were synthesized as PPARalpha agonists by incorporating polymethylene spacer as a replacement of commonly used phenylene group that connects the acidic head with lipophilic tail. Compound 13a was found to be a selective and potent PPARalpha agonist. Further 1,3-dioxane-2-carboxylic acid derivative 20 was synthesized by replacing the tetramethylene spacer of NS-220, a selective PPARalpha agonist with phenylene group and found to exhibit PPARalpha/gamma dual agonism. These results suggest that compounds possessing polymethylene spacer between pharmacophore and lipophilic tail exhibit predominantly PPARalpha agonism whereas those with an aromatic phenylene spacer shows PPARalpha/gamma dual agonism.

Topics: Butyrates; Chemistry, Pharmaceutical; Dioxanes; Drug Design; Glycine; Humans; Hydrogen; Hydrogen Bonding; Ligands; Models, Chemical; Oxazoles; Peroxisome Proliferator-Activated Receptors; PPAR alpha; Transcriptional Activation

2008