ns 2028 and oxadiazoles

Topics: Animals; Cattle; Cells, Cultured; Cerebellum; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Heme; Humans; In Vitro Techniques; Kinetics; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Oxazines; Rabbits; Solubility; Spectrophotometry; Structure-Activity Relationship; Swine; Umbilical Veins

Topics: Acetylcysteine; Animals; Biphenyl Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic GMP; Enzyme Activation; Free Radical Scavengers; Glomerular Mesangium; Glutathione; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Onium Compounds; Oxadiazoles; Oxazines; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rats; S-Nitrosoglutathione; Second Messenger Systems

Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Aorta, Thoracic; Benzoquinones; Calcium; Calmodulin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Hydroquinones; Imidazoles; In Vitro Techniques; Indoles; Isometric Contraction; Lactams, Macrocyclic; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Oxadiazoles; Oxazines; Quinones; Rabbits; Rifabutin; Staurosporine

Topics: Animals; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Oxazines; Rats; Rats, Wistar; Vasomotor System

Topics: Animals; Calcium; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Ion Channel Gating; Male; Nitroglycerin; Oxadiazoles; Oxazines; Peptides; Perfusion; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Regional Blood Flow; Regression Analysis; Swine; Vasodilator Agents

Topics: Animals; Benzoates; Cell Hypoxia; Cell Line; Cobalt; Coculture Techniques; Deferoxamine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Glutathione; Guanylate Cyclase; Hydrazines; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Inflammation; Kidney Tubules, Proximal; Macrophage Activation; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Oxides; Nitroso Compounds; Nuclear Proteins; Oxadiazoles; Oxazines; S-Nitrosoglutathione; Spermine; Swine; Transcription Factors

Topics: Animals; Chlorides; Colon; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Male; Nitric Oxide Donors; Oxadiazoles; Oxazines; Polyamines; Rats; Rats, Sprague-Dawley; Serotonin

Topics: Adenine; Animals; Benzoates; Cattle; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Mammary Arteries; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Oxazines; Oxidants; Peroxynitrous Acid; Vasodilation; Vasodilator Agents

Topics: Animals; Benzoates; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indazoles; Kidney; Male; Nervous System; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Norepinephrine; Oxadiazoles; Oxazines; Perfusion; Pressure; Rats; Rats, Wistar

Topics: 3' Untranslated Regions; Animals; Antigens, Surface; Aorta; Base Sequence; Blotting, Northern; Blotting, Western; Cell Nucleus; Cells, Cultured; Dactinomycin; Down-Regulation; ELAV Proteins; ELAV-Like Protein 1; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Molecular Sequence Data; Muscle, Smooth; Nucleic Acid Synthesis Inhibitors; Oxadiazoles; Oxazines; Poly A; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Soluble Guanylyl Cyclase; Time Factors; Transcription, Genetic; Transfection

Topics: Animals; Apoptosis; Carbazoles; Cell Line, Transformed; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA; DNA Fragmentation; Enzyme Inhibitors; Epithelial Cells; Female; Guanylate Cyclase; Indoles; Oxadiazoles; Oxazines; Quinoxalines; Signal Transduction; Uterus

Topics: Adenosine; Adenosine Triphosphate; Blood Platelets; Carbazoles; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Indoles; Insulin; Nitric Oxide; Oxadiazoles; Oxazines; Protein Kinase Inhibitors; Serotonin; Vasodilation

Topics: Adult; Cyclic GMP; Dibutyryl Cyclic GMP; Gastric Acid; Guanylate Cyclase; Histamine; Histamine Antagonists; Humans; Male; Nitric Oxide; Oxadiazoles; Oxazines; Parietal Cells, Gastric; S-Nitroso-N-Acetylpenicillamine

Topics: Animals; CD11b Antigen; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gene Expression Regulation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Neurodegenerative Diseases; Nitric Oxide; Oxadiazoles; Oxazines; Up-Regulation

Topics: Animals; Cells, Cultured; Chlorides; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Flavonoids; Guanylate Cyclase; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria, Heart; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxazines; Oxidation-Reduction; Penicillamine; Phosphorylation; Quinoxalines; Rats; Signal Transduction; Zinc; Zinc Compounds

Topics: Cell Movement; Cell Proliferation; Cells, Cultured; Cyclic GMP; Edema; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Humans; Immunity, Cellular; Inflammation; Lymphatic Vessels; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Oxazines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase

Topics: Antineoplastic Agents; Caspase 3; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclic GMP; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Humans; Male; Nitroprusside; Oxadiazoles; Oxazines; Prostatic Neoplasms; RNA Interference; Solubility

Topics: Animals; Aorta; Branchial Region; Carbon Monoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Hydrogen Sulfide; Muscle, Smooth, Vascular; Myography; Nitric Oxide; Nitroprusside; Norepinephrine; Oncorhynchus mykiss; Organometallic Compounds; Oxadiazoles; Oxazines; Petromyzon; Polarography; Potassium Channel Blockers; Potassium Chloride; Protoporphyrins; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

Topics: Animals; Aorta; Capillary Permeability; Cell Division; Cell Movement; Cells, Cultured; Cornea; Drug Interactions; Endothelial Cells; Enzyme Inhibitors; Fibroblast Growth Factor 2; Guanylate Cyclase; Humans; Neovascularization, Physiologic; Oxadiazoles; Oxazines; p38 Mitogen-Activated Protein Kinases; Rabbits; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Umbilical Veins; Vascular Endothelial Growth Factor A; Vasodilation

Topics: Animals; Coronary Vessels; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Muscle, Smooth, Vascular; Natriuretic Peptides; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxazines; Patch-Clamp Techniques; Peptides; Swine; Vasodilation

Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Blotting, Western; Cells, Cultured; Chromatography, Liquid; Cyclic GMP; Cytokines; Cytoprotection; Epitopes; Guanylate Cyclase; Immunohistochemistry; Lipopolysaccharides; Neuroglia; Nitric Oxide Synthase Type II; Nitrites; omega-N-Methylarginine; Oxadiazoles; Oxazines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic

Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Benzoates; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Cysteine; Enzyme Activation; Enzyme Activators; Fluorescence; Fluorescent Dyes; Guanylate Cyclase; Heme; Humans; Molecular Sequence Data; Mutation; Nitric Oxide; Oxadiazoles; Oxazines; Oxidation-Reduction; Protein Engineering; Receptors, Cytoplasmic and Nuclear; Rotenone; Signal Transduction; Soluble Guanylyl Cyclase; Spectrometry, Fluorescence

Topics: Adenosine Triphosphatases; Ammonia; Ammonium Chloride; Animals; Cardiotonic Agents; Creatine Kinase; Cyclic GMP; Guanylate Cyclase; Heart; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; KATP Channels; L-Lactate Dehydrogenase; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Oxazines; Perfusion; Pressure; Rats; Signal Transduction; Small-Conductance Calcium-Activated Potassium Channels; Sodium Hydroxide; Solubility

Topics: Animals; Carbon Monoxide; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Kupffer Cells; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Oxazines; Portal Pressure; Prostaglandins; Protoporphyrins; Rats; Rats, Sprague-Dawley

Topics: Adult; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxazines; Signal Transduction

Topics: Animals; Collagen; Conjunctiva; Cyclic GMP; Disease Progression; Eye; Guanylate Cyclase; Guinea Pigs; Injections; Myopia; Oxadiazoles; Oxazines; Radioimmunoassay; Retina; Sclera; Sensory Deprivation

Topics: Action Potentials; Animals; Calcium; Carbazoles; Carbon Monoxide; Enzyme Inhibitors; Ganglia, Invertebrate; Growth Cones; Heme Oxygenase-1; Neurons; Nitric Oxide; Organometallic Compounds; Oxadiazoles; Oxazines; Patch-Clamp Techniques; Pseudopodia; Quinoxalines; Signal Transduction; Snails; Time Factors

Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Colonic Neoplasms; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Resistance, Neoplasm; Drug Synergism; Drugs, Chinese Herbal; Humans; Hypoxia; Male; Mice, Inbred BALB C; Nitroso Compounds; Oxadiazoles; Oxazines; Phosphodiesterase 5 Inhibitors; Plant Extracts; Reactive Oxygen Species; Serum Albumin, Human; Soluble Guanylyl Cyclase; Vardenafil Dihydrochloride

Topics: Animals; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Genetic Variation; Heme; Humans; Moyamoya Disease; Oxadiazoles; Oxazines; Oxidation-Reduction; Protein Stability; Protein Structure, Secondary; Sf9 Cells; Soluble Guanylyl Cyclase