npc 15437 has been researched along with piperidines in 37 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 18 (48.65) | 18.2507 |
2000's | 12 (32.43) | 29.6817 |
2010's | 7 (18.92) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Lehmann, J; Mathis, C; Ungerer, A | 1 |
Burch, RM; Connor, JR; Shearer, BG; Sullivan, JP | 2 |
Burch, RM; Connor, JR; Shearer, BG; Sullivan, JP; Tiffany, C | 1 |
Gold, PE; Walker, DL | 2 |
Gopalakrishnan, V; Herman, RJ; Sandirasegarane, L | 1 |
Gopalakrishnan, V; Sandirasegarane, L; Xu, Y | 1 |
Eraly, SA; Mellon, PL; Wetsel, WC; Whyte, DB | 1 |
Lin, Q; Peng, YB; Willis, WD | 2 |
Kaufmann, SH; Sha, EC; Sha, MC | 1 |
Hsu, KS; Huang, CC; Yang, CH | 1 |
Chen, PS; Rees, H; Sluka, KA; Tsuruoka, M; Willis, WD | 2 |
Hsu, KS; Huang, CC | 1 |
Basso, MD; Cameron, NE; Cotter, MA; Hohman, TC; Jack, AM | 1 |
Ho, WC; Hsu, KS; Huang, CC; Tsai, JJ | 1 |
Cheng, BL; Coy, DH; Datta, R; Rossowski, WJ; Taylor, JE | 1 |
Jenks, BG; Lieste, JR; Roubos, EW; Scheenen, WJ; Schoenmakers, TJ; Willems, PH | 1 |
Fresco, P; Gonçalves, J; Pinto, E; Pinto, M; Saraiva, L; Sousa, E | 1 |
Chase, TN; Geller, AI; Oh, JD; Zhang, Gr | 1 |
Aujla, H; Beninger, RJ | 1 |
Fresco, P; Gonçalves, J; Pinto, E; Saraiva, L | 1 |
Hirate, K; Irifune, M; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K; Teramoto, T | 1 |
Irifune, M; Ishida, T; Mimura, T; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K | 1 |
Beck, JF; Felber, M; Sonnemann, J | 1 |
Kloc, R; Luchowska, E; Owe-Larsson, B; Urbanska, EM; Wielosz, M | 1 |
Cherng, CG; Chiang, CY; Fan, HY; Kao, GS; Lai, YT; Yu, L | 1 |
Cruijsen, PM; Jenks, BG; Roubos, EW; Scheenen, WJ; Schoeber, JP; van den Hurk, MJ | 1 |
Colado, MI; Izco, M; Lopez-Jimenez, A; Lopez-Moreno, JA; Mayado, A; O'Shea, E; Peraile, I; Torres, E | 1 |
Berrendero, F; Flores, Á; Maldonado, R; Martín-García, E; Plaza-Zabala, A; Saravia, R | 1 |
Almahariq, M; Chao, C; Cheng, X; Hellmich, MR; Mei, FC; Motamedi, M; Patrikeev, I | 1 |
Conde, K; Kelly, MJ; Meza, C; Sinchak, K; Wagner, EJ | 1 |
Coderre, TJ; Ding, S; Gyawali, S; Laferrière, A; Mahboubi, H; Mickeviciute, A; Nasir, H; Ragavendran, JV; Stochaj, U | 1 |
Busquets-Garcia, A; Galera-López, L; Gomis-González, M; Maldonado, R; Martín-García, E; Ozaita, A; Puighermanal, E; Salgado-Mendialdúa, V | 1 |
Devinney, MJ; Mitchell, GS | 1 |
37 other study(ies) available for npc 15437 and piperidines
Article | Year |
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The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice.
Topics: Amnesia; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Memory; Mice; Piperidines; Protein Kinase C; Receptors, N-Methyl-D-Aspartate | 1992 |
2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain.
Topics: Animals; Blood Platelets; Humans; Kinetics; Myosin-Light-Chain Kinase; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats | 1992 |
2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C.
Topics: Animals; Calcium; Cell Line; Edema; Mice; Myosin-Light-Chain Kinase; Phosphatidylserines; Piperidines; Protein Kinase C | 1991 |
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cell Line; DNA Mutational Analysis; Isoquinolines; Macromolecular Substances; Molecular Sequence Data; Mutation; Phorbol 12,13-Dibutyrate; Piperazines; Piperidines; Protein Conformation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Intra-amygdala kinase inhibitors disrupt retention of a learned avoidance response in rats.
Topics: Amygdala; Animals; Anti-Inflammatory Agents, Non-Steroidal; Avoidance Learning; Electroencephalography; Injections; Male; Memory; Piperidines; Polymyxin B; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Intrahippocampal administration of both the D- and the L-isomers of AP5 disrupt spontaneous alternation behavior and evoked potentials.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Male; Mental Recall; Orientation; Pain Threshold; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptic Transmission | 1994 |
High glucose attenuates peptide agonist-evoked increases in cytosolic free [Ca2+] in rat aortic smooth muscle cells.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Arginine Vasopressin; Calcium; Cells, Cultured; Culture Media; Cytosol; Endothelins; Glucose; Male; Mannose; Muscle, Smooth, Vascular; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C inhibitors enhance endothelin-1 and attenuate vasopressin and angiotensin II evoked [Ca2+]i elevation in the rat cardiomyocyte.
Topics: Alkaloids; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Cytosol; Endothelins; Fura-2; Myocardium; Piperidines; Protein Kinase C; Rats; Staurosporine | 1993 |
Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons.
Topics: Animals; Base Sequence; Cell Line, Transformed; Colforsin; Gonadotropin-Releasing Hormone; Hypothalamus; Molecular Sequence Data; Neurons; Oligonucleotide Probes; Piperidines; Protein Kinase C; Protein Kinases; Protein Precursors; Protein Processing, Post-Translational; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1993 |
Possible role of protein kinase C in the sensitization of primate spinothalamic tract neurons.
Topics: Animals; Capsaicin; Female; Injections, Intradermal; Macaca fascicularis; Male; Neural Inhibition; Neurons; Periaqueductal Gray; Physical Stimulation; Piperidines; Protein Kinase C; Spinothalamic Tracts; Tetradecanoylphorbol Acetate | 1996 |
Evaluation of 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)- hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cricetinae; Cricetulus; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Piperidines; Protein Kinase C; Tumor Cells, Cultured | 1996 |
Carbachol induces inward current in rat neostriatal neurons through a G-protein-coupled mechanism.
Topics: Animals; Carbachol; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Male; Muscarinic Agonists; Neostriatum; Neurons; Patch-Clamp Techniques; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1997 |
Involvement of protein kinase C in responses of rat dorsal horn neurons to mechanical stimuli and periaqueductal gray descending inhibition.
Topics: Animals; Dimethyl Sulfoxide; Electric Stimulation; Enzyme Activation; Lumbosacral Region; Neural Inhibition; Neurons; Periaqueductal Gray; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spinal Cord; Stress, Mechanical; Tetradecanoylphorbol Acetate | 1997 |
Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Animals; Capsaicin; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haplorhini; Hot Temperature; Injections, Intradermal; Isoquinolines; Microdialysis; Nerve Fibers; Neural Pathways; Physical Stimulation; Piperidines; Protein Kinase Inhibitors; Spinal Cord; Sulfonamides; Thalamus; Thionucleotides | 1997 |
Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor.
Topics: Animals; Biomechanical Phenomena; Capsaicin; Enzyme Activation; Enzyme Inhibitors; Macaca fascicularis; Nerve Fibers; Piperidines; Protein Kinase C; Spinothalamic Tracts; Temperature | 1997 |
Protein kinase C inhibitors block generation of anoxia-induced long-term potentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Hypoxia; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Neurons; Organ Culture Techniques; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Thionucleotides | 1998 |
Protein kinase C effects on nerve function, perfusion, Na(+), K(+)-ATPase activity and glutathione content in diabetic rats.
Topics: Alkaloids; Animals; Benzophenanthridines; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Male; Neural Conduction; Phenanthridines; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase | 1999 |
Prior short-term synaptic disinhibition facilitates long-term potentiation and suppresses long-term depression at CA1 hippocampal synapses.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Picrotoxin; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses; Thionucleotides | 1999 |
Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists.
Topics: Alkaloids; Animals; Aorta, Thoracic; Benzophenanthridines; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Genistein; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Peptide Fragments; Peptides, Cyclic; Phenanthridines; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; rho-Associated Kinases; Tyrphostins; Urotensins; Vasoconstriction | 2002 |
TRH signal transduction in melanotrope cells of Xenopus laevis.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Melanocyte-Stimulating Hormones; Membrane Potentials; Piperidines; Pituitary Gland; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Thapsigargin; Thyrotropin-Releasing Hormone; Xenopus laevis | 2002 |
Inhibition of protein kinase C by synthetic xanthone derivatives.
Topics: Alkaloids; Arachidonic Acid; Benzophenanthridines; Enzyme Inhibitors; Immunoblotting; Immunochemistry; Indicators and Reagents; Isoenzymes; Phenanthridines; Phenotype; Phosphatidylserines; Piperidines; Plasmids; Protein Kinase C; Saccharomyces cerevisiae; Tetradecanoylphorbol Acetate; Xanthines | 2003 |
Gene transfer of constitutively active protein kinase C into striatal neurons accelerates onset of levodopa-induced motor response alterations in parkinsonian rats.
Topics: Animals; Antiparkinson Agents; Blotting, Western; Corpus Striatum; Enzyme Inhibitors; Gene Transfer, Horizontal; Genetic Vectors; Herpesvirus 1, Human; Immunohistochemistry; Levodopa; Male; Models, Animal; Motor Activity; Neurons; Parkinsonian Disorders; Phosphorylation; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Time Factors | 2003 |
Intra-accumbens protein kinase C inhibitor NPC 15437 blocks amphetamine-produced conditioned place preference in rats.
Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Motor Activity; Nucleus Accumbens; Piperidines; Protein Kinase C; Rats; Rats, Wistar; Reward; Space Perception; Time Factors | 2003 |
Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta.
Topics: Acetophenones; Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Catalysis; Enzyme Inhibitors; Escherichia coli; Indoles; Isoenzymes; Phenanthridines; Piperidines; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Pyrroles; Saccharomyces cerevisiae; Sphingosine; Tamoxifen; Yeasts | 2003 |
Facilitative effect of a novel AVP fragment analog, NC-1900, on memory retention and recall in mice.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Enzyme Activators; Male; Memory; Mental Recall; Mice; Mice, Inbred Strains; Oligopeptides; Phorbol Esters; Piperidines; Protein Kinase C; Pyrrolidonecarboxylic Acid; Receptors, Vasopressin; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 2004 |
Ameliorative and exacerbating effects of [pGlu(4),Cyt(6)]AVP((4-9)) on impairment of step-through passive avoidance task performance by group II metabotropic glutamate receptor-related drugs in mice.
Topics: Amino Acids; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Memory; Mice; Mice, Inbred Strains; Piperidines; Protein Kinase C; Reaction Time; Receptors, Metabotropic Glutamate; Task Performance and Analysis | 2005 |
Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carbazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cerebellar Neoplasms; Drug Synergism; Humans; Indoles; Lung Neoplasms; Medulloblastoma; Peptide Fragments; Piperidines; Protein Kinase C-epsilon; Protein Kinase Inhibitors; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2007 |
Memantine increases brain production of kynurenic acid via protein kinase A-dependent mechanism.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Carbazoles; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic AMP-Dependent Protein Kinases; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoquinolines; Kynurenic Acid; Male; Memantine; Neurons; Piperidines; Pyrroles; Rats; Rats, Wistar | 2008 |
Activation of amygdaloid PKC pathway is necessary for conditioned cues-provoked cocaine memory performance.
Topics: Amygdala; Animals; Anisomycin; Cocaine; Conditioning, Classical; Cycloheximide; Dopamine Uptake Inhibitors; Extracellular Signal-Regulated MAP Kinases; Isoquinolines; Male; Memory; Mice; Mice, Inbred C57BL; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction; Space Perception; Sulfonamides | 2008 |
Intracellular signal transduction by the extracellular calcium-sensing receptor of Xenopus melanotrope cells.
Topics: Androstadienes; Animals; Blotting, Western; Butadienes; Cells, Cultured; Cholera Toxin; Cyclic AMP; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Intracellular Space; Mitogen-Activated Protein Kinases; Nitriles; Pertussis Toxin; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Radioimmunoassay; Receptors, Calcium-Sensing; Signal Transduction; Wortmannin; Xenopus laevis | 2008 |
Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice.
Topics: Animals; Cell Membrane; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Down-Regulation; Male; Mice; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Reward; Time Factors | 2010 |
A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior.
Topics: Animals; Benzoxazoles; Conditioning, Operant; Cues; Drug-Seeking Behavior; Extinction, Psychological; Hypothalamus; Isoquinolines; Male; Mice; Microinjections; Naphthyridines; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Receptors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Prefrontal Cortex; Protein Kinase Inhibitors; Pyridines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Self Administration; Signal Transduction; Urea | 2013 |
Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo.
Topics: Animals; Carcinoma, Pancreatic Ductal; Female; Gene Knockdown Techniques; Guanine Nucleotide Exchange Factors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Pancreatic Neoplasms; Piperidines | 2015 |
Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.
Topics: Animals; Drug Interactions; Enzyme Inhibitors; Estradiol; Estrenes; Estrogens; Female; Hypothalamus; In Vitro Techniques; Membrane Potentials; Neurons; Nociceptin; Nociceptin Receptor; Opioid Peptides; Ovariectomy; Piperidines; Pro-Opiomelanocortin; Pyrrolidinones; Rats; Rats, Long-Evans; Receptors, Opioid; Signal Transduction; Sodium Channel Blockers; Stilbamidines; Tetrodotoxin | 2016 |
Consistent sex-dependent effects of PKMζ gene ablation and pharmacological inhibition on the maintenance of referred pain.
Topics: Animals; Capsaicin; Cell-Penetrating Peptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Inflammation; Lipopeptides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia; Pain Threshold; Piperidines; Protein Kinase C; Rats; Rats, Long-Evans; Sex Characteristics; Spinal Cord | 2016 |
Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol.
Topics: Animals; Anisomycin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hippocampus; Isoenzymes; Male; Memory, Short-Term; Mice; Microinjections; Neurogranin; Phenols; Phosphorylation; Piperidines; Protein Kinase C; Quinoxalines; Rimonabant; Signal Transduction; Sirolimus | 2018 |
Spinal activation of protein kinase C elicits phrenic motor facilitation.
Topics: Analysis of Variance; Animals; Enzyme Inhibitors; Indoles; Male; Maleimides; Motor Neurons; Phrenic Nerve; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors | 2018 |