Page last updated: 2024-09-02

npc 12626 and morphine

npc 12626 has been researched along with morphine in 5 studies

Compound Research Comparison

Studies
(npc 12626)
Trials
(npc 12626)
Recent Studies (post-2010)
(npc 12626)
Studies
(morphine)
Trials
(morphine)
Recent Studies (post-2010) (morphine)
550044,2705,2008,695

Protein Interaction Comparison

ProteinTaxonomynpc 12626 (IC50)morphine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.2939
Delta-type opioid receptorRattus norvegicus (Norway rat)0.2278
Kappa-type opioid receptorMus musculus (house mouse)0.0828
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0385
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0545
Mu-type opioid receptorHomo sapiens (human)0.122
Delta-type opioid receptorHomo sapiens (human)0.1199
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.9308
Kappa-type opioid receptorHomo sapiens (human)0.655
Mu-type opioid receptorMus musculus (house mouse)0.3305
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.202
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.25

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kavaliers, M; Saucier, DM1
Ferkany, J; Kolesnikov, YA; Pasternak, GW1
Jain, S; Kolesnikov, Y; Pasternak, GW; Wilson, R1
Kolasiewicz, W; Popik, P1
D'Souza, DN; Garcia, MM; Harlan, RE1

Other Studies

5 other study(ies) available for npc 12626 and morphine

ArticleYear
Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice.
    Brain research, 1994, Feb-21, Volume: 637, Issue:1-2

    Topics: Amino Acids; Analgesics; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain Measurement; Peromyscus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa

1994
Blockade of mu and kappa 1 opioid analgesic tolerance by NPC17742, a novel NMDA antagonist.
    Life sciences, 1993, Volume: 53, Issue:19

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acids; Analgesics; Animals; Drug Tolerance; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu

1993
Blockade of morphine-induced hindlimb myoclonic seizures in mice by ketamine.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:3

    Topics: Amino Acids; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Excitatory Amino Acid Antagonists; Hindlimb; Ketamine; Male; Mice; Mice, Inbred Strains; Morphine; Receptors, N-Methyl-D-Aspartate; Stereoisomerism

1997
Mesolimbic NMDA receptors are implicated in the expression of conditioned morphine reward.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:4

    Topics: Amino Acids; Animals; Conditioning, Operant; Excitatory Amino Acid Antagonists; In Vitro Techniques; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Morphine; Morphine Dependence; Narcotics; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area

1999
Sexual dimorphism in the response to N-methyl-D-aspartate receptor antagonists and morphine on behavior and c-Fos induction in the rat brain.
    Neuroscience, 1999, Volume: 93, Issue:4

    Topics: Amino Acids; Animals; Behavior, Animal; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Genes, Immediate-Early; Male; Morphine; Narcotics; Neostriatum; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Thalamus

1999