noviose and 10-deoxymethynolide

noviose has been researched along with 10-deoxymethynolide* in 1 studies

Other Studies

1 other study(ies) available for noviose and 10-deoxymethynolide

Article	Year
Metabolic engineering of noviose: heterologous expression of novWUS and generation of a new hybrid antibiotic, noviosylated 10-deoxymethynolide/narbonolide, from Streptomyces venezuelae YJ003-OTBP1. Biotechnology letters, 2008, Volume: 30, Issue:9 NovW, novU and novS genes have been characterized as dTDP-4-keto-6-deoxy-D-glucose 3-epimerase, C-5 methyltransferase and dTDP-glucose 4-ketoreductase, respectively involved in noviose biosynthetic pathway. We have cloned and expressed the Streptomyces spheroids novWUS genes in S. venezuelae YJ003-OTBP1. This established the function of novWUS and, at the same time, it also proved that the noviosyl derivative of 10-deoxymethynolide(2)/narbonolide(4) obtained from S. venezuelae YJ003-OTBP1 is a novel hybrid antibiotic. Topics: Anti-Bacterial Agents; Biotechnology; Gene Expression Regulation, Bacterial; Genes, Bacterial; Macrolides; Mass Spectrometry; Microbial Sensitivity Tests; Monosaccharides; Streptomyces	2008

Article

Year

Metabolic engineering of noviose: heterologous expression of novWUS and generation of a new hybrid antibiotic, noviosylated 10-deoxymethynolide/narbonolide, from Streptomyces venezuelae YJ003-OTBP1.

Biotechnology letters, 2008, Volume: 30, Issue:9

NovW, novU and novS genes have been characterized as dTDP-4-keto-6-deoxy-D-glucose 3-epimerase, C-5 methyltransferase and dTDP-glucose 4-ketoreductase, respectively involved in noviose biosynthetic pathway. We have cloned and expressed the Streptomyces spheroids novWUS genes in S. venezuelae YJ003-OTBP1. This established the function of novWUS and, at the same time, it also proved that the noviosyl derivative of 10-deoxymethynolide(2)/narbonolide(4) obtained from S. venezuelae YJ003-OTBP1 is a novel hybrid antibiotic.

Topics: Anti-Bacterial Agents; Biotechnology; Gene Expression Regulation, Bacterial; Genes, Bacterial; Macrolides; Mass Spectrometry; Microbial Sensitivity Tests; Monosaccharides; Streptomyces

2008