nov-002 has been researched along with wiskostatin* in 2 studies
2 other study(ies) available for nov-002 and wiskostatin
Article | Year |
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The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na(+) transport in frog skin.
Using voltage-clamp technique, the involvement of WASP proteins and Arp2/3 complex in the effect of immunomodulator drug glutoxim on Na(+) transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with the N-WASP inhibitor wiskostatin or the Arp2/3 complex inhibitor CK-0944666 significantly decreases the stimulatory effect of glutoxim on Na(+) transport. The data suggest the involvement of actin filament polymerization and branching in the glutoxim effect on Na(+) transport in frog skin. Topics: Actin-Related Protein 2-3 Complex; Animals; Carbazoles; Dermatologic Agents; Epithelial Cells; Indoles; Male; Oligopeptides; Patch-Clamp Techniques; Propanolamines; Rana temporaria; Skin; Sodium; Wiskott-Aldrich Syndrome Protein | 2016 |
Involvement of the Arp2/3 complex and WASP proteins in the effect of glutoxim and molixan on intracellular Ca(2+) concentration in macrophages.
The Fura-2AM fluorescent Ca(2+) probe was used to study the possibility that the Arp2/3 complex and WASP proteins are involved in the effects of glutoxim and molixan on the intracellular Ca(2+) concentration in macrophages. It has been demonstrated that preincubation of macrophages with inhibitors of the Arp2/3 complex or WASP proteins (CK-0944666 or wiskostatin, respectively) results in a significant suppression of Ca(2+)-responses induced by glutoxim or molixan. This suggests that polymerization of actin filaments is a process involved in the effect of glutoxim or molixan on intracellular Ca(2+) concentration in macrophages. Topics: Actin-Related Protein 2-3 Complex; Animals; Calcium; Carbazoles; Cations, Divalent; Cells, Cultured; Drug Combinations; Fluorescent Dyes; Fura-2; Glutathione; Indoles; Inosine; Macrophages, Peritoneal; Oligopeptides; Propanolamines; Rats, Wistar; Voltage-Sensitive Dye Imaging; Wiskott-Aldrich Syndrome Protein Family | 2015 |