nov-002 and perftoran

Results of surgical treatment of 114 patients, suffering spreaded peritonitis of various etkoogy, were analyzed. To patients of the comparison group basic conservative therapy was conducted. In patients of the main group was applied intravenous infusion of ozonated perftoran (OP) in 1 mg/kg dose, concentration of ozone 5 mg/l, solely or together with metabolic immunomodulator and detoxicator glutoxim. To all the patients the routine clinical investigations were conducted: in the blood erythrocytes there were measured concentration of diane conjugates, of malonic dialdehyde, activity of catalase, content of the middle molecular mass peptides in blood and urine, as well as of rest nitrogen, urea, creatinine, common bilirubin, state of the protein and electrolyte balance. Basing on analysis of results of the conducted investigations there was revealed, that combined, local and systematic, application of OP and glutoxim together with basic therapy in spreaded peritonitis is pathogenetically substantiated.

Topics: Adolescent; Adult; Aged; Biomarkers; Drug Administration Schedule; Drug Therapy, Combination; Fluorocarbons; Humans; Injections, Intraperitoneal; Injections, Intravenous; Middle Aged; Oligopeptides; Ozone; Peritonitis; Severity of Illness Index; Treatment Outcome; Young Adult

The immune status was studied while surgical treatment of 74 patients, suffering extended peritonitis (EP). In 38 patients (group of comparison) a complex routine therapy was conducted, in 36 (the main group)--along with routine complex measures of treatment a local and systemic ozonotherapy, using ozonized perftoran (OP) and glutoxim (for immunocorrection), were applied. The patients severity state was estimated in accordance to the Mahnheim's peritoneal index. In all the patients while hospitalization there were revealed changes in T--and B--links of immunity, in phagocytosis and the cytokins profile, significant of which have depended upon the EP severity. The combined local and systemic application of OP and glutoxim in complex of conservative treatment is pathogenetically substantiated, it permits more rapidly to eliminate the immunity disorders and the cytokines balance, as well as inflammatory process in abdominal cavity and to improve the results of surgical treatment significantly.

Topics: Adolescent; Adult; Aged; B-Lymphocytes; Blood Substitutes; Case-Control Studies; Drug Therapy, Combination; Female; Fluorocarbons; Humans; Immunity, Innate; Immunologic Factors; Interleukin-4; Interleukin-8; Male; Middle Aged; Oligopeptides; Ozone; Peritonitis; Severity of Illness Index; T-Lymphocytes; Tumor Necrosis Factor-alpha