nov-002 has been researched along with fura-2-am* in 3 studies
3 other study(ies) available for nov-002 and fura-2-am
| Article | Year |
|---|---|
5-Lipoxygenase inhibitor zileuton inhibits Ca(2+)-responses induced by glutoxim and molixan in macrophages.
Using Fura-2AM microfluorimetry, we have shown for the first time that 5-lipoxygenase specific inhibitor antiasthmatic agent zileuton significantly inhibits Ca(2+)-responses induced by glutoxim and molixan in macrophages. The results support 5-lipoxygenase involvement in the effect of glutoxim and molixan on intracellular Ca(2+) concentration in macrophages and indicate the inadvisability of a combined use of drugs glutoxim and molixan and antiasthmatic agent zileuton. Topics: Animals; Anti-Asthmatic Agents; Arachidonate 5-Lipoxygenase; Calcium; Calcium Signaling; Cations, Divalent; Cells, Cultured; Cytophotometry; Drug Combinations; Drug Interactions; Fura-2; Hydroxyurea; Inosine; Intracellular Space; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Microscopy, Fluorescence; Oligopeptides; Rats, Wistar | 2016 |
Methyl-β-cyclodextrin inhibits Ca
Using Fura-2AM microfluorimetry, we have shown for the first time that methyl-β-cyclodextrin, inducing cholesterol extraction from membranes and raft disruption, significantly inhibits glutoxim- and molixan-induced Ca Topics: Animals; beta-Cyclodextrins; Calcium; Calcium Signaling; Cations, Divalent; Cells, Cultured; Cholesterol; Drug Combinations; Drug Interactions; Fluorescent Dyes; Fluorometry; Fura-2; Inosine; Lipid Regulating Agents; Macrophages, Peritoneal; Membrane Microdomains; Membrane Transport Modulators; Oligopeptides; Rats, Wistar | 2016 |
Involvement of the Arp2/3 complex and WASP proteins in the effect of glutoxim and molixan on intracellular Ca(2+) concentration in macrophages.
The Fura-2AM fluorescent Ca(2+) probe was used to study the possibility that the Arp2/3 complex and WASP proteins are involved in the effects of glutoxim and molixan on the intracellular Ca(2+) concentration in macrophages. It has been demonstrated that preincubation of macrophages with inhibitors of the Arp2/3 complex or WASP proteins (CK-0944666 or wiskostatin, respectively) results in a significant suppression of Ca(2+)-responses induced by glutoxim or molixan. This suggests that polymerization of actin filaments is a process involved in the effect of glutoxim or molixan on intracellular Ca(2+) concentration in macrophages. Topics: Actin-Related Protein 2-3 Complex; Animals; Calcium; Carbazoles; Cations, Divalent; Cells, Cultured; Drug Combinations; Fluorescent Dyes; Fura-2; Glutathione; Indoles; Inosine; Macrophages, Peritoneal; Oligopeptides; Propanolamines; Rats, Wistar; Voltage-Sensitive Dye Imaging; Wiskott-Aldrich Syndrome Protein Family | 2015 |