nov-002 and emoxypine-succinate

The effects of various combinations of pharmacological agents on parameters characterizing red blood cell (RBC) membrane proteins and lipids have been investigated in RBC isolated from Wistar male rats with acute destructive pancreatitis induced under conditions of forced alcoholization for 60 days. Administration of a combination of Hepon, Hypoxenum, and Phosphogliv normalized 22.5% of parameters altered change during development of acute destructive pancreatitis under conditions of chronic alcoholization of parameters, corrected towards normal values 42.5% of parameters (35% of parameters remained unchanged). Administration of Glutoxim, Mexidol and Heptral, was more effective: this combination normalized 50.0% of parameters studied, corrected towards normal values 37.5% of parameters, leaving unchanged only 12.5% of parameters studied.. V éksperimente izucheny vozmozhnosti korrektsii izmeneniĭ soderzhaniia belkov i lipidov membrany krasnykh kletok krovi i narusheniĭ vnutrikletochnogo metabolizma éritrotsitov pri ostrom destruktivnom pankreatite na fone 60-dnevnoĭ intoksikatsii étanolom putem ispol'zovaniia razlichnykh sochetaniĭ immunomoduliatorov, antioksidantov i membranoprotektorov. Vyiavleny izmeneniia soderzhaniia belkov, otvetstvennykh za vnutrikletochnyĭ metabolizm éritrotsitov (aniontransportnyĭ belok, glitseral'al'degid-3-fosfatdegidrogenaza, glutation-S-transferaza, belok polosy 4.5), strukturoobrazovanie, stabilizatsiiu (a- i b-spektrin, dematin, ankirin, belok polosy 4.1, pallidin), formoobrazovanie i gibkost' (aktin, tropomiozin) membrany. Ustanovlennye narusheniia urovnia i sootnosheniia lipidnykh fraktsiĭ membrany, igraiushchikh osnovnuiu rol' v uporiadochivanii belkovykh makromolekul i metabolizme éritrotsitov, nariadu s izmeneniiami arkhitektoniki belkov, narushaiut vnutrikletochnyĭ metabolizm i funktsional'nye svoĭstva éritrotsitov. Primenenie sochetaniia gepon, gipoksen i fosfogliv normalizuet 22,5% izmenennykh v usloviiakh ostrogo destruktivnogo pankreatita i khronicheskoĭ alkogolizatsii parametrov, korrigiruet 42,5% i ostavliaet bez izmeneniia 35%. Bolee éffektivnym okazalos' primenenie glutoksima, meksidola i geptrala, tak kak normalizovalo i korrigirovalo 50,0% i 37,5% parametrov, ostaviv bez izmeneniia 12,5% pokazateleĭ.

Topics: Acute Disease; Animals; Drug Combinations; Erythrocytes; Ethanol; Glycyrrhizic Acid; Male; Oligopeptides; Pancreatitis; Phosphatidylcholines; Picolines; Rats; Rats, Wistar