noscapine and isoquinoline

Noscapine is a natural product first isolated from the opium poppy (Papaver somniferum L.) with anticancer properties. In this work, we report the synthesis and cellular screening of a noscapine-based library. A library of novel noscapine derivatives was synthesized with modifications in the isoquinoline and phthalide scaffolds. The so generated library, consisting of fifty-seven derivatives of the natural product noscapine, was tested against MDA-MB-231 breast cancer cells in a cellular proliferation assay (with a Z' > 0.7). The screening resulted in the identification of two novel noscapine derivatives as inhibitors of MDA cell growth with IC

Topics: Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Isoquinolines; Noscapine; Papaver; Protein Binding; Small Molecule Libraries; Tubulin