nortilidine has been researched along with naloxone in 3 studies
| Studies (nortilidine) | Trials (nortilidine) | Recent Studies (post-2010) (nortilidine) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 17 | 7 | 6 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | nortilidine (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arnold, P; Doser, K; Gaupp, M; Martin, W; Ring, J; Sennewald, R | 1 |
| Brennscheidt, U; Seiler, KU; Thomann, P | 1 |
| Grün, B; Merkel, U; Mikus, G; Riedel, KD; Weiss, J | 1 |
3 trial(s) available for nortilidine and naloxone
| Article | Year |
|---|---|
Bioavailability investigation of a new tilidine/naloxone liquid formulation compared to a reference formulation.
Topics: Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Chromatography, Thin Layer; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Mass Spectrometry; Middle Aged; Naloxone; Narcotic Antagonists; Reference Standards; Tilidine | 1999 |
Pharmacokinetics of nortilidine and naloxone after administration of tilidine/naloxone solution or tilidine/naloxone sustained release tablets.
Topics: Adult; Area Under Curve; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Half-Life; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Regression Analysis; Tilidine | 2000 |
Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine.
Topics: Adult; Analgesics, Opioid; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Genotype; Half-Life; Humans; Male; Middle Aged; Naloxone; Polymorphism, Genetic; Prodrugs; Ritonavir; Tilidine; Time Factors; Young Adult | 2012 |