nortilidine has been researched along with ent-dextilidine in 17 studies
| Studies (nortilidine) | Trials (nortilidine) | Recent Studies (post-2010) (nortilidine) | Studies (ent-dextilidine) | Trials (ent-dextilidine) | Recent Studies (post-2010) (ent-dextilidine) |
|---|---|---|---|---|---|
| 17 | 7 | 6 | 148 | 36 | 22 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hengy, H; Thomann, P; Vollmer, KO | 1 |
| Bolze, S; Boulieu, R | 1 |
| Arnold, P; Doser, K; Gaupp, M; Martin, W; Ring, J; Sennewald, R | 1 |
| Brennscheidt, U; Heintz, B; Jähnchen, E; Seiler, KU; Trenk, D | 1 |
| Brennscheidt, U; Seiler, KU; Thomann, P | 1 |
| Hajda, JP; Jähnchen, E; Oie, S; Trenk, D | 1 |
| Boeynaems, JM; Paolo, M; Thierry, C | 1 |
| Kuepper, U; Madea, B; Musshoff, F; Trafkowski, J | 1 |
| Dettmeyer, R; Madea, B; Thierauf, A; Wollersen, H | 1 |
| Haefeli, WE; Mikus, G; Riedel, KD; Sawa, E; Weiss, J | 1 |
| Grün, B; Krautter, S; Mikus, G; Riedel, KD | 1 |
| Binscheck, T; Grobosch, T; Köhler, C | 1 |
| Mikus, G; Riedel, KD; Weiss, J; Wustrow, I | 1 |
| Grün, B; Merkel, U; Mikus, G; Riedel, KD; Weiss, J | 1 |
| Baumgartner, MR; Kraemer, T; Poetzsch, M; Steuer, AE | 1 |
| Blank, A; Burhenne, J; Eichbaum, C; Markert, C; Mathes, K; Mikus, G | 1 |
| Blank, A; Burhenne, J; Emrich, O; Meid, AD; Merbach, M; Mikus, G; Stammler, G; Wolfert, C | 1 |
7 trial(s) available for nortilidine and ent-dextilidine
| Article | Year |
|---|---|
Bioavailability investigation of a new tilidine/naloxone liquid formulation compared to a reference formulation.
Topics: Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Chromatography, Thin Layer; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Mass Spectrometry; Middle Aged; Naloxone; Narcotic Antagonists; Reference Standards; Tilidine | 1999 |
Pharmacokinetics of tilidine in terminal renal failure.
Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prodrugs; Renal Dialysis; Tilidine | 2001 |
Pharmacokinetics of nortilidine and naloxone after administration of tilidine/naloxone solution or tilidine/naloxone sustained release tablets.
Topics: Adult; Area Under Curve; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Half-Life; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Regression Analysis; Tilidine | 2000 |
Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Cross-Over Studies; Humans; Injections, Intravenous; Male; Models, Biological; Prodrugs; Tilidine; Time Factors | 2002 |
Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Double-Blind Method; Drug Interactions; Female; Humans; Male; Middle Aged; Pyrimidines; Tilidine; Triazoles; Voriconazole; Young Adult | 2009 |
Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine.
Topics: Adult; Analgesics, Opioid; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Genotype; Half-Life; Humans; Male; Middle Aged; Naloxone; Polymorphism, Genetic; Prodrugs; Ritonavir; Tilidine; Time Factors; Young Adult | 2012 |
Pre-systemic elimination of tilidine: localization and consequences for the formation of the active metabolite nortilidine.
Topics: Adult; Alkynes; Analgesics, Opioid; Benzoxazines; Beverages; Chromatography, Liquid; Citrus paradisi; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 CYP3A; Female; Half-Life; Humans; Male; Middle Aged; Tandem Mass Spectrometry; Tilidine; Young Adult | 2015 |
10 other study(ies) available for nortilidine and ent-dextilidine
| Article | Year |
|---|---|
Pharmacokinetics of tilidine and metabolites in man.
Topics: Administration, Oral; Adult; Chromatography, Gas; Cyclohexanecarboxylic Acids; Half-Life; Humans; Injections, Intravenous; Male; Tilidine | 1989 |
HPLC determination of ketamine, norketamine, and dehydronorketamine in plasma with a high-purity reversed-phase sorbent.
Topics: Acetates; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Ketamine; Methylene Chloride; Sensitivity and Specificity; Tilidine | 1998 |
Actions of tilidine and nortilidine on cloned opioid receptors.
Topics: Animals; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Receptors, Opioid; Tilidine | 2005 |
An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites.
Topics: Analgesics, Opioid; Chromatography, Liquid; Fentanyl; Humans; Morphine Derivatives; Palliative Care; Patient Compliance; Spectrometry, Mass, Electrospray Ionization; Tilidine | 2006 |
Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Central Nervous System Depressants; Coronary Vessel Anomalies; Female; Forensic Pathology; Humans; Myocardium; Pyrethrins; Tilidine; Trimipramine | 2007 |
In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Recombinant Proteins; Tandem Mass Spectrometry; Tilidine | 2008 |
Rapid quantification of tilidine, nortilidine, and bisnortilidine in urine by automated online SPE-LC-MS/MS.
Topics: Automation; Chromatography, Liquid; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Tilidine | 2011 |
In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Tilidine | 2012 |
Segmental hair analysis for differentiation of tilidine intake from external contamination using LC-ESI-MS/MS and MALDI-MS/MS imaging.
Topics: Adult; Chromatography, Liquid; Forensic Toxicology; Hair; Humans; Infant; Male; Middle Aged; Narcotics; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tilidine | 2015 |
[Management of chronic pain using extended release tilidine : Quality of life and implication of comedication on tilidine metabolism].
Topics: Adult; Aged; Aged, 80 and over; Chronic Pain; Delayed-Action Preparations; Drug Interactions; Drug Therapy, Combination; Female; Humans; Kidney Function Tests; Liver Function Tests; Male; Middle Aged; Quality of Life; Tilidine | 2017 |