norketamine has been researched along with rifampin in 2 studies
| Studies (norketamine) | Trials (norketamine) | Recent Studies (post-2010) (norketamine) | Studies (rifampin) | Trials (rifampin) | Recent Studies (post-2010) (rifampin) |
|---|---|---|---|---|---|
| 220 | 32 | 122 | 20,468 | 1,499 | 6,552 |
| Protein | Taxonomy | norketamine (IC50) | rifampin (IC50) |
|---|---|---|---|
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 2.949 | |
| Caspase-1 | Homo sapiens (human) | 8.319 | |
| Alpha-synuclein | Homo sapiens (human) | 7.1 | |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | 0.03 | |
| DNA-directed RNA polymerase subunit beta | Mycobacterium tuberculosis H37Rv | 0.01 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.5 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 1.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aarts, L; Dahan, A; Kharasch, E; Mooren, R; Niesters, M; Noppers, I; Olofsen, E; Sarton, E | 1 |
| Hagelberg, NM; Kurkinen, KJ; Laine, K; Neuvonen, PJ; Olkkola, KT; Peltoniemi, MA; Saari, TI | 1 |
2 trial(s) available for norketamine and rifampin
| Article | Year |
|---|---|
Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Infusions, Intravenous; Ketamine; Male; Rifampin; Single-Blind Method | 2011 |
Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine.
Topics: Administration, Oral; Analgesics; Biological Availability; Biotransformation; Cross-Over Studies; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Half-Life; Humans; Injections, Intravenous; Ketamine; Male; Metabolic Clearance Rate; Psychomotor Performance; Rifampin; Sleep Stages | 2012 |