Page last updated: 2024-09-03

norketamine and ketamine

norketamine has been researched along with ketamine in 204 studies

Compound Research Comparison

Studies
(norketamine)
Trials
(norketamine)
Recent Studies (post-2010)
(norketamine)
Studies
(ketamine)
Trials
(ketamine)
Recent Studies (post-2010) (ketamine)
2203212215,0292,3216,678

Protein Interaction Comparison

ProteinTaxonomynorketamine (IC50)ketamine (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)4.216
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)4.216
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)5.02
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)5.02
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)3.7762
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)3.5563
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)4.1059
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)5.02
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)5.02
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)5.02

Research

Studies (204)

TimeframeStudies, this research(%)All Research%
pre-199013 (6.37)18.7374
1990's16 (7.84)18.2507
2000's46 (22.55)29.6817
2010's101 (49.51)24.3611
2020's28 (13.73)2.80

Authors

AuthorsStudies
Baillie, TA; Leung, LY2
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR1
Kharasch, ED; Labroo, R1
Brune, K; Geisslinger, G; Kamp, HD; Menzel-Soglowek, S1
Calvo, MB; Dominguez-Gil, A; Gascon, AR; Hernandez, R; Muriel, C; Pedraz, JL; Torres, LM1
Courtot, D; Delatour, P; Fau, D; Jaussaud, P1
Fassbender, CP; Ganter, M; Löscher, W1
Calvo, MB; Domínguez-Gil, A; Lanao, JM; Muriel, C; Pedraz, JL; Santos Lamas, J1
Calvo, MB; Domínguez-Gil, A; Hernández-Arbeiza, J; Lanao, JM; Muriel, C; Pedraz, JL1
Adams, JD; Woolf, TF1
Hondo, T; Hoshino, T; Saito, M; Senda, M; Tohei, S1
Clements, JA; Grant, IS; McNicol, LR; Nimmo, WS1
Waterman, AE1
Hall, GM; Lacoumenta, S; Paterson, JL; Walsh, ES; Ward, I; Waterman, AE1
Dayton, PG; Hug, CC; Perel, JM; Stiller, RL1
Holasek, J; Idvall, J; Stenberg, P1
Davisson, JN; Hong, SC1
Adams, JD; Baillie, TA; Castagnoli, N; Trevor, AJ1
Breivik, H; Eide, PK; Stubhaug, A; Øye, I1
Bushnell, TG; Craig, J1
Akeson, J; Björkman, S; Messeter, K; Rośen, I1
Akeson, J; Björkman, S; Helfer, M; Messeter, K; Rosén, I1
Hartvig, P; Joachimsson, PO; Larsson, E1
Flaherty, D; McCormack, R; Monteiro, AM; Nolan, A; Reid, J; Welsh, E1
Gustafsson, LL; Svensson, JO1
Cozian, A; Lepage, JY; Malinovsky, JM; Pinaud, M; Servin, F1
Borgbjerg, FM; Ebert, B; Mikkelsen, S; Thorkildsen, C1
Bolze, S; Boulieu, R1
Elliott, KJ; Gorman, AL; Inturrisi, CE; Shimoyama, M; Shimoyama, N1
Aoyama, T; Iga, T; Kariya, S; Ohtani, M; Uchino, K; Yamamura, Y; Yanagihara, Y1
Bolon, M; Boulieu, R; Hijazi, Y1
Edwards, SR; Mather, LE1
Jacobs, AJ; Levine, B; Moore, KA; Sklerov, J1
Boulieu, R; Hijazi, Y1
Aoyama, T; Ashizawa, N; Hiraishi, T; Iga, T; Kariya, S; Ohtani, M; Uchino, K; Yamada, Y; Yamamura, Y; Yanagihara, Y1
Bodonian, C; Bolon, M; Boulieu, R; Hijazi, Y; Salord, F1
Patel, S; Rodriguez Rosas, ME; Wainer, IW1
Chou, SL; Giang, YS; Ling, YC; Yang, MH1
Lin, HR; Lua, AC1
Cheng, SG; Shih, TS; Wang, KC1
Biallas, R; Gruber, M; Weber, F; Wulf, H1
Adamowicz, P; Juhascik, MP; Moore, CM; Negrusz, A; Saini, BK; Schlemmer, RF; Webster, DE1
Huang, MK; Huang, SD; Li, JH; Liu, C1
Knobloch, M; Larenza, P; Levionnois, O; Mevissen, M; Theurillat, R; Thormann, W1
Ilkiw, JE; Pypendop, BH1
Boscan, P; Ilkiw, JE; Pypendop, BH; Solano, AM1
Hsieh, YZ; Jen, HP; Su, HL; Tsai, YC1
Abelson, KS; Goldkuhl, RR; Höglund, AU; Nylund, A1
Shen, M; Xiang, P; Zhuo, X1
Knobloch, M; Levionnois, OL; Mevissen, M; Portier, CJ; Spadavecchia, C; Theurillat, R; Thormann, W1
In, MK; Kim, JH; Kim, JY1
Knobloch, M; Kronen, PW; Landoni, MF; Larenza, MP; Levionnois, OL; Schatzmann, U; Theurillat, R; Thormann, W2
Huang, MH; Lee, HH; Liu, RH; Tsai, JL; Wu, CH; Wu, MY1
Cheng, PS; Chien, CS; Fu, CY; Lee, CH; Liu, C1
Choi, SK; Chung, HS; Kim, EM; Lee, JS; Lim, MA1
Knobloch, M; Lassahn, PG; Mevissen, M; Schmitz, A; Theurillat, R; Thormann, W1
di Fabio, P; Nigro, V; Romagnoli, N; Roncada, P; Spadari, A; Zaghini, A1
Anderson, BJ; Herd, DW; Holford, NH1
Cheng, PS; Chien, CS; Lee, CH; Liu, C1
Chen, LL; He, R; Huang, LY; Li, WJ; Lia, OL; Ma, XN; Yan, YY; Yang, L1
Crooks, PA; Holtman, JR; Johnson-Hardy, J; Wala, EP1
Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP1
Andersen, OK; Arendt-Nielsen, L; Bergadano, A; Spadavecchia, C; Theurillat, R; Thormann, W1
Grummett, SA; VandenBoer, TC; Watterson, JH1
Braithwaite, RA; Cowan, DA; Elliott, SP; Halket, JM; Kicman, AT; Osselton, MD; Parkin, MC; Smith, NW; Turfus, SC1
Mevissen, M; Portier, CJ; Schmitz, A; Theurillat, R; Thormann, W1
Apley, MD; Coetzee, JF; Gehring, R; Tarus-Sang, J1
Chong, C; Ilett, KF; Jenkins, B; Page-Sharp, M; Schug, SA1
Braithwaite, RA; Cowan, DA; Elliot, SP; Halket, JM; Kicman, AT; Parkin, MC; Smith, NW; Steventon, GB; Turfus, SC1
Fukushima, T; Inagaki, S; Makino, H; Min, JZ; Toyo'oka, T1
Landoni, MF; Larenza, MP; Levionnois, OL; Peterbauer, C; Schatzmann, U; Spadavecchia, C; Thormann, W1
Armelloni, S; Berra, S; Carraro, M; Corbelli, A; Giardino, L; Guerrot, D; Ikehata, M; Li, M; Mattinzoli, D; Messa, P; Rastaldi, MP; Tourrel, F; Zennaro, C1
Lassahn, PG; Mevissen, M; Schmitz, A; Theurillat, R; Thormann, W1
Azad, SC; Beyer, A; Huge, V; Lauchart, M; Magerl, W; Schelling, G; Thieme, D1
Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M1
In, MK; Kim, JY; Shin, SH1
Balikova, M; Brunovsky, M; Bubenikova-Valesova, V; Horacek, J; Hoschl, C; Koprivova, J; Mohr, P; Novak, T; Palenicek, T; Spaniel, F; Tislerova, B1
In, MK; Kim, JY; Lee, JI; Shin, SH1
Cox, K; Gamble, M; Rohrig, TP1
Anderson, RA; Cormack, PA; Harun, N1
Lee, SF; Lin, HL; Lin, HR; Liu, C; Lua, AC1
Bärtsch, P; Berger, MM; Dahan, A; Hollmann, MW; Mairbäurl, H; Pitzer, B; Schultz, MJ; Vlaar, AP; Wieland, CW; Zügel, S1
Kwan, HY; Mevissen, M; Portmann, S; Schmitz, A; Theurillat, R; Thormann, W1
Goldberg, ME; Mager, DE; Schwartzman, RJ; Torjman, MC; Wainer, IW1
Bodoki, E; Chiap, P; Crommen, J; Fillet, M; Gillotin, F; Rousseau, A; Servais, AC1
Choi, RC; Dong, TT; Fu, Q; Lau, DT; Leung, KW; Ng, WY; Ting, AK; Tsim, KW; Wang, T; Wong, ZC; Zhu, KY1
Shen, B; Shen, M; Sun, Q; Xiang, P1
Jia, J; Liu, L; Wang, YJ; Wei, ZW1
Inoue, H; Miyaguchi, H1
Anderson, BJ; Brunette, KE; Herd, DW; Schulein, S; Thomas, J; Wiesner, L1
Aarts, L; Dahan, A; Kharasch, E; Mooren, R; Niesters, M; Noppers, I; Olofsen, E; Sarton, E1
Aarts, L; Dahan, A; Morariu, A; Niesters, M; Swartjes, M1
Hagelberg, NM; Laine, K; Neuvonen, PJ; Olkkola, KT; Peltoniemi, MA; Saari, TI2
Hagelberg, NM; Laine, K; Neuvonen, PJ; Olkkola, KT; Peltoniemi, MA; Reponen, P; Saari, TI; Turpeinen, M1
Chen, C; Lin, HR; Lua, AC; Sulake, RS1
Donohue, JP; Watterson, JH1
Cheong, JC; In, MK; Kim, JY; Lee, JI; Son, JH1
Kwan, HY; Thormann, W1
Li, H; Lin, JM; Mao, S; Wei, H1
Mevissen, M; Mössner, LD; Schmitz, A; Theurillat, R; Thormann, W1
Brutsche, NE; Ibrahim, L; Luckenbaugh, DA; Mager, DE; Moaddel, R; Venkata, SL; Wainer, IW; Zarate, CA; Zhao, X1
Brutsche, N; Diazgranados, N; Franco-Chaves, J; Henter, ID; Ibrahim, L; Kronstein, P; Luckenbaugh, DA; Manji, HK; Moaddel, R; Wainer, I; Zarate, CA1
Cheng, JY; Cheung, ST; Lee, VW; Sin, DW; Wong, YC1
Brutsche, NE; Cornwell, BR; Furey, M; Grillon, C; Marquardt, CA; Salvadore, G; Zarate, CA1
Betit, CC; Donohue, JP; Watterson, JH1
Desta, Z; Goldberg, ME; Moaddel, R; Ogburn, ET; Ramamoorthy, A; Sanghvi, M; Torjman, MC; Venkata, SL; Wainer, IW; Xu, C1
Hagelberg, NM; Kurkinen, KJ; Laine, K; Neuvonen, PJ; Olkkola, KT; Peltoniemi, MA; Saari, TI1
Aarts, L; Dahan, A; Kharasch, E; Niesters, M; Noppers, I; Olofsen, E; Sarton, E1
Chang, YZ; Her, GR; Hung, SH; Liu, CR; Ma, YC; Wang, CW1
Akhlaghi, F; Linakis, JG; Machan, JT; Steele, DW; Tsze, DS1
Dahan, A; Niesters, M1
Aarts, L; Dahan, A; Khalili-Mahani, N; Martini, C; Niesters, M; Rombouts, S; van Buchem, MA; van Gerven, J1
Thormann, W; Ying Kwan, H1
Chen, SJ; Huang, MH; Lin, KH; Shen, AY; Wu, FT; Wu, SN1
Favretto, D; Ferrara, SD; Nalesso, A; Stocchero, G; Terranova, C; Tucci, M; Vogliardi, S1
Hu, B; Ng, TT; So, PK; Wang, H; Yao, ZP1
Holland, MG; Marraffa, JM; Ryzewski, M; Sullivan, RW1
Bruno, R; Carter, S; Lai, FY; Lam, PK; Leung, HW; Mueller, JF; Ort, C; Thai, PK; Thompson, K1
Lee, WN; Lin, AY; Wang, XH1
Bettschart-Wolfensberger, R; Feige, K; Larenza, MP; Theurillat, R; Thormann, W1
Almeida, RM; Bairros, AV; Lanaro, R; Yonamine, M1
Brallier, JW; Charney, DS; Feder, A; Iosifescu, DV; Lapidus, KA; Levitch, CF; Murrough, JW; Parides, MK; Perez, AM; Soleimani, L1
Dahan, A; van Velzen, M1
Bernier, M; Green, CE; Khadeer, M; Moaddel, R; O'Loughlin, K; Paul, RK; Sanghvi, M; Singh, NS; Torjman, MC; Wainer, IW1
Liu, J; Osgood, SM; Shaffer, CL; Smith, DL; Trapa, PE1
Cornthwaite, HM; Watterson, JH1
Jokinen, V; Kalso, EA; Lilius, TO; Neuvonen, MS; Niemi, M; Rauhala, PV1
Bernier, M; Moaddel, R; Singh, NS; Wainer, IW; Zarate, CA1
Di Corcia, D; Diana, P; Gerace, E; Malvaso, V; Romeo, M; Salomone, A; Vincenti, M1
Backman, JT; Fanta, S; Kalso, E; Kinnunen, M1
Denny, W; Gamage, S; Harvey, M; Jose, J; Liyanage, S; Pruijn, F; Sleigh, J; Voss, L1
Drabik, U; Gajdosz, R; Librowski, T; Nowak, G; Popik, P; Sałat, K; Siwek, A; Starowicz, G1
Barroso, M; Cruz, A; Gallardo, E; Martinho, A; Moreno, I1
Hagelberg, NM; Olkkola, KT; Peltoniemi, MA; Saari, TI1
Beaudry, F; Chevrette, J; Dodelet-Devillers, A; Gourdon, J; Hélie, P; Vachon, P; Zullian, C1
Bortolotti, F; De Palo, EF; Musile, G; Porpiglia, N; Tagliaro, F1
Barreto, AS; Brant, VF; Rodrigues, SV; Spinelli, E1
Glatz, Z; Mosher, RA; Pelcová, M; Řemínek, R; Sandbaumhüter, FA; Thormann, W1
Fassauer, GM; Hasan, M; Hofstetter, R; Link, A; Oswald, S; Siegmund, W1
Bai, YM; Chen, MH; Cheng, CM; Gueorguieva, R; Hong, CJ; Krystal, JH; Li, CT; Lin, WC; Su, TP; Tu, PC1
Barbarossa, A; Bektas, RN; Bettschart-Wolfensberger, R; Hartnack, S; Kutter, AP; Romagnoli, N; Roncada, P1
Li, SW; Lin, AY; Wang, YH1
Arıöz, F; Göktaş, EF1
Banks, A; Gao, J; Jiang, G; Lai, FY; Li, J; Mueller, JF; Thai, PK1
Boudy, V; D'Hayer, B; Fonsart, J; Houzé, P; Legagneux, J; Ramiole, C1
Fassauer, GM; Hasan, M; Hofstetter, R; Link, A; Modeß, C; Oswald, S; Siegmund, W1
Moorthy, GS; Tran, BD; Zuppa, AF1
Ichikawa, T; Mizuno-Yasuhira, A; Toki, H; Yamaguchi, JI1
Hashimoto, K; Shirayama, Y1
Downey, L; Green, M; Hayley, A; Keane, M; Kostakis, P; Shehabi, Y1
Alonzo, A; Gálvez, V; Glue, P; Huggins, C; Li, A; Loo, CK; Martin, D; Mitchell, PB; Rodgers, A; Somogyi, AA1
Sandbaumhüter, FA; Thormann, W1
Kalso, E; Kangas, E; Lilius, T; Niemi, M; Rauhala, P1
Mikkonen, S; Thormann, W1
Chaki, S; Hashimoto, K; Koike, H; Mizuno-Yasuhira, A; Qu, Y; Toki, H; Yamaguchi, JI; Yang, C1
Glue, P; Goulton, C; Le Nedelec, M; Medlicott, NJ; Winter, H1
Chaki, S; Dong, C; Han, M; Hashimoto, K; Kobayashi, S; Ma, M; Manabe, T; Nakao, K; Nakazawa, K; Qu, Y; Ren, Q; Shirayama, Y; Toki, H; Yamaguchi, JI; Yang, C; Zhang, JC1
Du, P; Li, XQ; Wang, CC; Yang, J; Zhang, HF1
Chen, L; Gong, Y; Salter, R1
Hashimoto, K; Yang, C1
Kabbaj, M; Saland, SK1
Ide, S; Ikeda, K1
Buvanendran, A; Das, V; Kroin, JS; Moric, M1
Sommerová, B; Tůma, P; Vaculín, Š1
Baumgartner, C; Fux, D; Knubben, G; Metzner, M; Rieger, A; Steckeler, P1
Adame, BC; Crawford, CA; Gomez, V; McDougall, SA; Park, GI; Ramirez, GI1
Adams, M; Downey, LA; Green, M; Hayley, AC; Keane, M; Kenneally, M; Shehabi, Y1
García-Ruiz, C; Matey, JM; Montalvo, G; Moreno de Simon, MD1
Hashimoto, K2
Burke, AK; Choo, TH; Cooper, TB; Galfalvy, HC; Grunebaum, MF; Mann, JJ; Parris, MS; Suckow, RF1
Chang, L; Fujita, A; Fujita, Y; Hashimoto, K; Pu, Y1
Hashimoto, K; Luo, A; Yang, C; Yang, J1
Hirose, H; Kaushal, G; Kraft, WK; Lam, E; Rochani, A; Tanjuakio, J1
Brandner, B; Curran, HV; Das, RK; Gale, G; Hennessy, VE; Iskandar, G; Kamboj, SK; Kindt, M; Mordecai, LA; Walsh, K1
Glatz, Z; Řemínek, R; Thormann, W1
Glue, P; Hung, CT; Hung, N; Lam, F; Medlicott, NJ; Surman, P1
Ago, Y; Chen, L; Hashimoto, H; Hashimoto, K; Higuchi, M; Kasai, A; Naito, M; Nakagawa, S; Nakazawa, T; Seiriki, K; Tanabe, W; Tsukada, S; Yamaguchi, T; Yokoyama, R1
Barter, LS; Luca, GC; Pypendop, BH1
Ahmad, SM; Neng, NR; Nogueira, JMF; Oliveira, MN1
Bickerdike, MJ; Denny, WA; Dimitrov, IV; Harvey, MG; Sleigh, JW; Voss, LJ1
Aarts, L; Dahan, A; Jonkman, K; Kamp, J; Niesters, M; Olofsen, E; van Velzen, M1
Arora, B; Ghose, S; Lalwani, S; Saxena, R; Velpandian, T1
Jang, M; Kim, J; Lee, J; Lee, S; Rhee, J; Shin, I1
Glue, P; Medlicott, NJ; Russell, B1
Carrola, JS; Gonçalves, R; M F Gonçalves, V; Pereira, JA; Pérez-Pereira, A; Pires, C; Ribeiro, C; Teles, F; Tiritan, ME1
Chen, Y; Hu, L; Wen, C; Wu, Y; Ying, L; Zhong, Z1
Bergmann, KR; Jacobs, G; Otto, ME; van Esdonk, MJ1
Chen, CK; Chen, YT; Dash, S; Hsieh, YJ; Hsu, YC; Huang, MC; Liu, JC; Wu, CC; Wu, CT; Yu, JS1
Barbarossa, A; Bardhi, A; Gazzotti, T; Pagliuca, G1
Denk, W; Katz, D; Lauritsen, C; Lovett, J; Moaddel, R; Schwenk, ES; Silberstein, SD; Torjman, MC; Wainer, IW1
Huang, C; Jiang, R; Liu, C; Wang, Y; Wu, Z; Xu, J; Yan, E; Yang, C; Yang, L; Zhou, L; Zhu, B1
Gardier, AM; McGowan, JC; Nguyen, TML1
Chen, PL; Chyueh, SC; Huang, DY; Lee, LW; Liu, YL; Tsai, YS; Tseng, SH; Yen, YT1
Andraus, M; Barroso, M; Gallardo, E; Oliveira, P; Rosado, T; Rosendo, LM; Simão, AY1
Endo, H; Mizuno-Yasuhira, A; Toki, H; Yamaguchi, JI1
Gee, P; Mackenzie, E; Schep, LJ; Slaughter, RJ; Watts, M1
Alshogran, OY; Caritis, SN; Lim, G; Pakalapati, N; Shahane, A; Shaik, IH; Venkataramanan, R; Zhao, W1
Can, AT; Dutton, M; Hermens, DF; Lagopoulos, J1

Reviews

10 review(s) available for norketamine and ketamine

ArticleYear
Pharmacokinetic and pharmacodynamic considerations for NMDA receptor antagonists in the treatment of chronic neuropathic pain.
    Expert opinion on drug metabolism & toxicology, 2012, Volume: 8, Issue:11

    Topics: Animals; Chronic Disease; Disease Models, Animal; Humans; Ketamine; Neuralgia; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate

2012
Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy.
    Clinical pharmacokinetics, 2016, Volume: 55, Issue:9

    Topics: Analgesics; Anesthesia; Animals; Biological Availability; Central Nervous System; Child; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Administration Routes; Humans; Ketamine; Pain; Receptors, N-Methyl-D-Aspartate

2016
A review of chromatographic methods for ketamine and its metabolites norketamine and dehydronorketamine.
    Biomedical chromatography : BMC, 2018, Volume: 32, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry

2018
Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.
    Psychiatry and clinical neurosciences, 2019, Volume: 73, Issue:10

    Topics: Animals; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; History, 20th Century; History, 21st Century; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate

2019
Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites.
    Translational psychiatry, 2019, 11-07, Volume: 9, Issue:1

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Hippocampus; Humans; Ketamine; Prefrontal Cortex; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stress, Psychological

2019
Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine.
    Biochemical pharmacology, 2020, Volume: 177

    Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Depression; Gastrointestinal Microbiome; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Spleen

2020
Influence of formulation and route of administration on ketamine's safety and tolerability: systematic review.
    European journal of clinical pharmacology, 2021, Volume: 77, Issue:5

    Topics: Antidepressive Agents; Dissociative Disorders; Drug Administration Routes; Drug Delivery Systems; Humans; Hypertension; Ketamine; Metabolic Clearance Rate

2021
CYP 450 enzymes influence (R,S)-ketamine brain delivery and its antidepressant activity.
    Neuropharmacology, 2022, 03-15, Volume: 206

    Topics: Animals; Antidepressive Agents; Cytochrome P-450 Enzyme System; Humans; Ketamine

2022
The clinical toxicology of ketamine.
    Clinical toxicology (Philadelphia, Pa.), 2023, Volume: 61, Issue:6

    Topics: Analgesics; Anesthetics; Animals; Cytochrome P-450 CYP2B6; Humans; Ketamine

2023
Oral ketamine may offer a solution to the ketamine conundrum.
    Psychopharmacology, 2023, Volume: 240, Issue:12

    Topics: Antidepressive Agents; Biological Availability; Humans; Ketamine; Pain

2023

Trials

29 trial(s) available for norketamine and ketamine

ArticleYear
Effects of ketamine anaesthesia on the metabolic response to pelvic surgery.
    British journal of anaesthesia, 1984, Volume: 56, Issue:5

    Topics: Adult; Anesthesia, Intravenous; Blood Glucose; Fallopian Tubes; Fatty Acids, Nonesterified; Female; Halothane; Hematocrit; Hemodynamics; Humans; Hydrocortisone; Intraoperative Period; Ketamine; Lactates; Lactic Acid; Pyruvates; Pyruvic Acid

1984
Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children.
    British journal of anaesthesia, 1996, Volume: 77, Issue:2

    Topics: Administration, Intranasal; Administration, Rectal; Anesthetics, Dissociative; Child; Child, Preschool; Humans; Injections, Intravenous; Ketamine

1996
S-ketamine and s-norketamine plasma concentrations after nasal and i.v. administration in anesthetized children.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:12

    Topics: Administration, Intranasal; Analgesics; Analysis of Variance; Child; Child, Preschool; Humans; Infant; Injections, Intravenous; Ketamine; Prospective Studies; Time Factors

2004
Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies.
    British journal of anaesthesia, 2007, Volume: 98, Issue:2

    Topics: Anesthesia, General; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Blood Pressure; Cross-Over Studies; Drug Administration Schedule; Electrocardiography; Heart Rate; Horses; Isoflurane; Ketamine; Male; Monitoring, Intraoperative; Stereoisomerism

2007
Development of a sublingual/oral formulation of ketamine for use in neuropathic pain: Preliminary findings from a three-way randomized, crossover study.
    Clinical drug investigation, 2009, Volume: 29, Issue:5

    Topics: Administration, Oral; Administration, Sublingual; Adult; Aged; Analgesics; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Chronic Disease; Cross-Over Studies; Drug Stability; Drug Storage; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine; Male; Middle Aged; Neuralgia; Temperature

2009
Use of human microsomes and deuterated substrates: an alternative approach for the identification of novel metabolites of ketamine by mass spectrometry.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8

    Topics: Administration, Oral; Anesthetics, Dissociative; Biotransformation; Chromatography, Liquid; Consciousness; Cyclotrons; Deuterium; Female; Fourier Analysis; Glucuronides; Humans; Hydrogen-Ion Concentration; Isomerism; Ketamine; Male; Metabolomics; Microsomes, Liver; Molecular Structure; Phenols; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry

2009
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
    European journal of pain (London, England), 2010, Volume: 14, Issue:4

    Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular System; Female; Hemodynamics; Humans; Ketamine; Male; Middle Aged; Pain; Pain Measurement; Peripheral Nervous System Diseases; Stereoisomerism

2010
Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect.
    Psychological medicine, 2010, Volume: 40, Issue:9

    Topics: Adult; Affect; Anesthetics, Dissociative; Biomarkers; Cross-Over Studies; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Ketamine; Male; Predictive Value of Tests; Prefrontal Cortex; Theta Rhythm

2010
Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.
    Anesthesiology, 2011, Volume: 114, Issue:6

    Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Infusions, Intravenous; Ketamine; Male; Rifampin; Single-Blind Method

2011
St John's wort greatly decreases the plasma concentrations of oral S-ketamine.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:6

    Topics: Adult; Analgesics; Antidepressive Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Humans; Hypericum; Ketamine; Male; Neuropsychological Tests; Plant Preparations; Psychomotor Performance; Regression Analysis; Young Adult

2012
Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine.
    Clinical pharmacology and therapeutics, 2011, Volume: 90, Issue:2

    Topics: Administration, Oral; Adult; Anesthetics, Dissociative; Antifungal Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Double-Blind Method; Drug Interactions; Female; Humans; Itraconazole; Ketamine; Male; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult

2011
S-ketamine concentrations are greatly increased by grapefruit juice.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:6

    Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Beverages; Citrus paradisi; Cross-Over Studies; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Female; Food-Drug Interactions; Humans; Ketamine; Male; Middle Aged; Oxidoreductases, N-Demethylating; Young Adult

2012
Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression.
    British journal of clinical pharmacology, 2012, Volume: 74, Issue:2

    Topics: Adult; Algorithms; Antidepressive Agents; Biotransformation; Bipolar Disorder; Cross-Over Studies; Double-Blind Method; Drug Resistance; Female; Humans; Hydroxylation; Infusions, Parenteral; Ketamine; Male; Middle Aged; Models, Biological; Young Adult

2012
Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:6

    Topics: Adolescent; Adult; Aged; Depression; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged; Outcome Assessment, Health Care; Psychiatric Status Rating Scales; Riluzole; Time Factors; Young Adult

2012
Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression.
    Biological psychiatry, 2012, Oct-01, Volume: 72, Issue:7

    Topics: Adult; Analysis of Variance; Antidepressive Agents; Brain Mapping; Cerebral Cortex; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Electric Stimulation; Female; Fingers; Functional Laterality; Humans; Ketamine; Magnetoencephalography; Male; Middle Aged; Psychiatric Status Rating Scales; Reaction Time; Synaptic Potentials; Time Factors; Treatment Outcome

2012
Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:5

    Topics: Administration, Oral; Analgesics; Biological Availability; Biotransformation; Cross-Over Studies; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Half-Life; Humans; Injections, Intravenous; Ketamine; Male; Metabolic Clearance Rate; Psychomotor Performance; Rifampin; Sleep Stages

2012
Estimation of the contribution of norketamine to ketamine-induced acute pain relief and neurocognitive impairment in healthy volunteers.
    Anesthesiology, 2012, Volume: 117, Issue:2

    Topics: Acute Pain; Adolescent; Adult; Analgesics; Cognition; Hot Temperature; Humans; Ketamine; Male; Memory; Pain Management; Pain Measurement; Psychomotor Performance; Reaction Time; Reference Values; Single-Blind Method; Young Adult

2012
Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report.
    Pediatric emergency care, 2012, Volume: 28, Issue:8

    Topics: Administration, Intranasal; Anesthetics, Dissociative; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Infant; Ketamine; Lacerations; Prospective Studies

2012
Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteers.
    Anesthesiology, 2012, Volume: 117, Issue:4

    Topics: Adult; Anesthetics, Dissociative; Brain; Data Interpretation, Statistical; Hallucinogens; Hot Temperature; Humans; Image Processing, Computer-Assisted; Injections, Intravenous; Ketamine; Linear Models; Magnetic Resonance Imaging; Male; Nerve Net; Pain; Pain Measurement; Single-Blind Method; Young Adult

2012
A randomized controlled trial of intranasal ketamine in major depressive disorder.
    Biological psychiatry, 2014, Dec-15, Volume: 76, Issue:12

    Topics: Administration, Intranasal; Adult; Aged; Antidepressive Agents; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Female; Follow-Up Studies; Humans; Ketamine; Male; Middle Aged; Psychiatric Status Rating Scales; Time Factors; Treatment Outcome; Young Adult

2014
Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:13

    Topics: Adult; Antidepressive Agents; Asian People; Blood Pressure; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Ketamine; Male; Middle Aged; Polymorphism, Genetic; Psychiatric Status Rating Scales; Taiwan; Treatment Outcome

2017
Pharmacokinetics of ketamine and norketamine enantiomers after racemic or S-ketamine IV bolus administration in dogs during sevoflurane anaesthesia.
    Research in veterinary science, 2017, Volume: 112

    Topics: Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Chromatography, Liquid; Cross-Over Studies; Dogs; Infusions, Intravenous; Injections, Intravenous; Ketamine; Male; Methyl Ethers; Sevoflurane

2017
Repeated intranasal ketamine for treatment-resistant depression - the way to go? Results from a pilot randomised controlled trial.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:4

    Topics: Administration, Intranasal; Administration, Intravenous; Adult; Analgesics; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Female; Humans; Ketamine; Male; Midazolam; Middle Aged; Pilot Projects; Treatment Outcome

2018
The course of plasma cortisol concentration after three different doses of ketamine in xylazine-premedicated calves.
    Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:3

    Topics: Anesthesia; Anesthetics, Dissociative; Animals; Cattle; Dose-Response Relationship, Drug; Female; Hydrocortisone; Ketamine; Male; Pain Measurement; Premedication; Prospective Studies; Random Allocation; Single-Blind Method; Xylazine

2019
Neurocognitive performance under combined regimens of ketamine-dexmedetomidine and ketamine-fentanyl in healthy adults: A randomised trial.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 08-30, Volume: 94

    Topics: Adult; Choice Behavior; Dexmedetomidine; Drug Synergism; Female; Fentanyl; Humans; Ketamine; Male; Memory, Short-Term; Reaction Time; Recognition, Psychology; Young Adult

2019
Ketamine metabolite pilot study in a suicidal depression trial.
    Journal of psychiatric research, 2019, Volume: 117

    Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Humans; Infusions, Parenteral; Ketamine; Midazolam; Outcome Assessment, Health Care; Pilot Projects; Severity of Illness Index; Suicidal Ideation

2019
Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories.
    Nature communications, 2019, 11-26, Volume: 10, Issue:1

    Topics: Adaptation, Psychological; Adult; Alcohol Drinking; Biomarkers; Female; Humans; Ketamine; Male; Memory; Reinforcement, Psychology; Treatment Outcome

2019
Ascending-Dose Study of Controlled-Release Ketamine Tablets in Healthy Volunteers: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability.
    Journal of clinical pharmacology, 2020, Volume: 60, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Antidepressive Agents; Area Under Curve; Blood Pressure; Brain-Derived Neurotrophic Factor; Delayed-Action Preparations; Dissociative Disorders; Double-Blind Method; Drug Administration Schedule; Female; Healthy Volunteers; Humans; Ketamine; Male; Middle Aged; Tablets; Time Factors; Young Adult

2020
Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis.
    British journal of anaesthesia, 2020, Volume: 125, Issue:5

    Topics: Adult; Anesthetics, Dissociative; Biotransformation; Computer Simulation; Cross-Over Studies; Double-Blind Method; Drug Compounding; Female; Humans; Injections, Intravenous; Ketamine; Male; Models, Theoretical; Nitroprusside; Postoperative Complications; Stereoisomerism; Young Adult

2020

Other Studies

165 other study(ies) available for norketamine and ketamine

ArticleYear
Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:11

    Topics: Anesthesia; Animals; Brain; Ketamine; Male; Rats; Rats, Inbred Strains

1986
Highly predictive and interpretable models for PAMPA permeability.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

2017
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
    Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14

    Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

2019
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
    Scientific reports, 2020, 11-26, Volume: 10, Issue:1

    Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

2020
Metabolism of ketamine stereoisomers by human liver microsomes.
    Anesthesiology, 1992, Volume: 77, Issue:6

    Topics: Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Ketamine; Microsomes, Liver; Stereoisomerism

1992
Stereoselective high-performance liquid chromatographic determination of the enantiomers of ketamine and norketamine in plasma.
    Journal of chromatography, 1991, Jul-17, Volume: 568, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Ketamine

1991
Pharmacokinetics and distribution of ketamine after extradural administration to dogs.
    British journal of anaesthesia, 1991, Volume: 67, Issue:3

    Topics: Anesthesia, Epidural; Anesthesia, General; Animals; Biotransformation; Brain; Dogs; Female; Half-Life; Ketamine; Male

1991
Enantioselective N-demethylation of ketamine in the horse.
    Journal of veterinary pharmacology and therapeutics, 1991, Volume: 14, Issue:2

    Topics: Animals; Chromatography; Horses; Injections, Intravenous; Ketamine; Male; Molecular Conformation

1991
Correlation between drug and metabolite concentrations in plasma and anesthetic action of ketamine in swine.
    American journal of veterinary research, 1990, Volume: 51, Issue:3

    Topics: Anesthesia; Animals; Female; Injections, Intramuscular; Injections, Intravenous; Ketamine; Male; Swine; Time Factors

1990
Pharmacokinetics of rectal ketamine in children.
    British journal of anaesthesia, 1989, Volume: 63, Issue:6

    Topics: Administration, Rectal; Child; Half-Life; Humans; Ketamine

1989
Studies on the biotransformation of ketamine. II--Quantitative significance of the N-demethylation pathway in rats in vivo determined by a novel stable isotope technique.
    Biomedical & environmental mass spectrometry, 1989, Volume: 18, Issue:6

    Topics: Animals; Biotransformation; Dealkylation; Deuterium; Ketamine; Male; Rats; Rats, Inbred Strains

1989
Pharmacokinetic and clinical evaluation of ketamine administered by i.v. and epidural routes.
    International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:2

    Topics: Adult; Aged; Blood Pressure; Cardiac Output; Half-Life; Humans; Injections, Epidural; Injections, Intravenous; Ketamine; Kinetics; Middle Aged; Respiration

1987
Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations.
    Xenobiotica; the fate of foreign compounds in biological systems, 1987, Volume: 17, Issue:7

    Topics: Animals; Biotransformation; Chromatography, Gas; Humans; In Vitro Techniques; Ketamine; Male; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Spectrum Analysis; Stereoisomerism

1987
Quantitative deconvolution of heavily fused chromatographic peaks of biological components using a multi-wavelength UV detector.
    Journal of chromatography, 1985, Sep-20, Volume: 332

    Topics: Animals; Chemical Phenomena; Chemistry; Ketamine; Rabbits; Spectrophotometry, Ultraviolet

1985
Ketamine disposition in children and adults.
    British journal of anaesthesia, 1983, Volume: 55, Issue:11

    Topics: Adult; Aged; Anesthesia, General; Child; Child, Preschool; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Ketamine; Kinetics; Male; Middle Aged; Time Factors

1983
Influence of premedication with xylazine on the distribution and metabolism of intramuscularly administered ketamine in cats.
    Research in veterinary science, 1983, Volume: 35, Issue:3

    Topics: Animals; Cats; Female; Injections, Intramuscular; Ketamine; Kinetics; Male; Preanesthetic Medication; Thiazines; Tissue Distribution; Xylazine

1983
Gas chromatographic analysis of ketamine and norketamine in plasma and urine: nitrogen-sensitive detection.
    Journal of chromatography, 1982, Nov-12, Volume: 232, Issue:2

    Topics: Adult; Animals; Child; Chromatography, Gas; Dogs; Haplorhini; Humans; Ketamine; Kinetics; Nitrogen

1982
Rectal ketamine for induction of anaesthesia in children.
    Anaesthesia, 1983, Volume: 38, Issue:1

    Topics: Anesthesia, Rectal; Atropine; Child; Diazepam; Female; Half-Life; Humans; Ketamine; Kinetics; Male; Preanesthetic Medication

1983
Stereochemical studies of demethylated ketamine enantiomers.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:8

    Topics: Anesthetics; Animals; Ketamine; Male; Mice; Molecular Conformation; Stereoisomerism

1982
Studies on the biotransformation of ketamine. 1-Identification of metabolites produced in vitro from rat liver microsomal preparations.
    Biomedical mass spectrometry, 1981, Volume: 8, Issue:11

    Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Ketamine; Male; Microsomes, Liver; Rats; Rats, Inbred Strains

1981
Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia.
    Pain, 1995, Volume: 61, Issue:2

    Topics: Aged; Female; Herpesviridae Infections; Humans; Infusion Pumps, Implantable; Ketamine; Male; Neuralgia; Prospective Studies; Receptors, N-Methyl-D-Aspartate

1995
Response of chronic neuropathic pain syndromes to ketamine: a role for norketamine?
    Pain, 1995, Volume: 60, Issue:1

    Topics: Humans; Ketamine; Pain; Pain, Intractable

1995
Low-dose midazolam antagonizes cerebral metabolic stimulation by ketamine in the pig.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:6

    Topics: Acid-Base Equilibrium; Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Electroencephalography; Hydrogen-Ion Concentration; Ketamine; Midazolam; Oxygen Consumption; Swine; Vascular Resistance

1993
Cerebral pharmacodynamics of anaesthetic and subanaesthetic doses of ketamine in the normoventilated pig.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:2

    Topics: Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Electroencephalography; Hydrogen-Ion Concentration; Infusions, Intravenous; Ketamine; Oxygen; Oxygen Consumption; Respiration; Swine; Time Factors; Vascular Resistance

1993
Postoperative analgesia and sedation following pediatric cardiac surgery using a constant infusion of ketamine.
    Journal of cardiothoracic and vascular anesthesia, 1993, Volume: 7, Issue:2

    Topics: Analgesia; Cardiac Surgical Procedures; Child, Preschool; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Infusions, Intravenous; Intensive Care Units, Pediatric; Intubation, Intratracheal; Ketamine; Midazolam; Postoperative Care; Postoperative Period; Respiration, Artificial; Ventilator Weaning

1993
Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine: a pharmacokinetic study.
    Research in veterinary science, 1996, Volume: 60, Issue:3

    Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; Horses; Imidazoles; Infusions, Intravenous; Ketamine; Metabolic Clearance Rate; Premedication; Propofol

1996
Determination of ketamine and norketamine enantiomers in plasma by solid-phase extraction and high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1996, Apr-12, Volume: 678, Issue:2

    Topics: Anesthetics, Dissociative; Chromatography, High Pressure Liquid; Humans; Ketamine; Methanol; Microchemistry; Stereoisomerism

1996
Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord.
    European journal of pharmacology, 1997, Aug-20, Volume: 333, Issue:1

    Topics: Animals; Animals, Newborn; Binding, Competitive; Cerebral Cortex; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ketamine; Phencyclidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stereoisomerism

1997
HPLC determination of ketamine, norketamine, and dehydronorketamine in plasma with a high-purity reversed-phase sorbent.
    Clinical chemistry, 1998, Volume: 44, Issue:3

    Topics: Acetates; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Ketamine; Methylene Chloride; Sensitivity and Specificity; Tilidine

1998
Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine.
    Pain, 1999, Volume: 81, Issue:1-2

    Topics: Administration, Oral; Animals; Behavior, Animal; Binding, Competitive; Central Nervous System; Formaldehyde; Injections, Spinal; Ketamine; Male; Nociceptors; Osmolar Concentration; Pain; Rats; Rats, Sprague-Dawley

1999
Stereoselective high-performance liquid chromatographic determination of ketamine and its active metabolite, norketamine, in human plasma.
    Journal of chromatography. B, Biomedical sciences and applications, 2000, Sep-15, Volume: 746, Issue:2

    Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Humans; Ketamine; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism

2000
Stability of ketamine and its metabolites norketamine and dehydronorketamine in human biological samples.
    Clinical chemistry, 2001, Volume: 47, Issue:9

    Topics: Blood Specimen Collection; Chromatography, High Pressure Liquid; Humans; Ketamine; Temperature; Time Factors

2001
Tissue uptake of ketamine and norketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion.
    Life sciences, 2001, Sep-14, Volume: 69, Issue:17

    Topics: Animals; Area Under Curve; Ketamine; Liver; Male; Rats; Rats, Wistar; Stereoisomerism; Tissue Distribution

2001
Urine concentrations of ketamine and norketamine following illegal consumption.
    Journal of analytical toxicology, 2001, Volume: 25, Issue:7

    Topics: Anesthetics, Dissociative; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Mass Spectrometry; Reference Values; Sensitivity and Specificity; Substance Abuse Detection

2001
Protein binding of ketamine and its active metabolites to human serum.
    European journal of clinical pharmacology, 2002, Volume: 58, Issue:1

    Topics: Anesthetics, Dissociative; Blood Proteins; Humans; Ketamine; Protein Binding; Ultrafiltration

2002
Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers.
    Biopharmaceutics & drug disposition, 2003, Volume: 24, Issue:1

    Topics: Administration, Intranasal; Adult; Analysis of Variance; Area Under Curve; Chemistry, Pharmaceutical; Humans; Ketamine; Male; Stereoisomerism; Vaginal Creams, Foams, and Jellies

2003
Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury.
    British journal of anaesthesia, 2003, Volume: 90, Issue:2

    Topics: Adult; Analysis of Variance; Anesthetics, Dissociative; Blood Pressure; Brain Injuries; Critical Care; Female; Half-Life; Heart Rate; Hemodynamics; Humans; Ketamine; Male; Metabolic Clearance Rate; Middle Aged; Spinal Cord Injuries

2003
Determination of the enantiomers of ketamine and norketamine in human plasma by enantioselective liquid chromatography-mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Aug-25, Volume: 794, Issue:1

    Topics: Calibration; Chromatography, Liquid; Humans; Ketamine; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism

2003
Gas chromatography-isotope dilution mass spectrometry preceded by liquid-liquid extraction and chemical derivatization for the determination of ketamine and norketamine in urine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Jan-05, Volume: 799, Issue:1

    Topics: Anesthetics, Dissociative; Gas Chromatography-Mass Spectrometry; Ketamine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity

2004
Detection of acid-labile conjugates of ketamine and its metabolites in urine samples collected from pub participants.
    Journal of analytical toxicology, 2004, Volume: 28, Issue:3

    Topics: Dancing; Gas Chromatography-Mass Spectrometry; Humans; Hydrochloric Acid; Hydrolysis; Illicit Drugs; Ketamine; Reproducibility of Results; Taiwan

2004
Use of SPE and LC/TIS/MS/MS for rapid detection and quantitation of ketamine and its metabolite, norketamine, in urine.
    Forensic science international, 2005, Jan-06, Volume: 147, Issue:1

    Topics: Anesthetics, Dissociative; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Molecular Structure; Substance Abuse Detection

2005
Detection of ketamine and norketamine in urine of nonhuman primates after a single dose of ketamine using microplate enzyme-linked immunosorbent assay (ELISA) and NCI-GC-MS.
    Journal of analytical toxicology, 2005, Volume: 29, Issue:3

    Topics: Animals; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Injections, Intramuscular; Ketamine; Macaca; Male; Models, Animal; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection; Time Factors

2005
Quantitative detection of ketamine, norketamine, and dehydronorketamine in urine using chemical derivatization followed by gas chromatography-mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Jun-25, Volume: 820, Issue:2

    Topics: Anesthetics, Dissociative; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Reproducibility of Results; Sensitivity and Specificity

2005
Characterization of the stereoselective biotransformation of ketamine to norketamine via determination of their enantiomers in equine plasma by capillary electrophoresis.
    Electrophoresis, 2005, Volume: 26, Issue:20

    Topics: Anesthetics; Animals; Biotransformation; Calibration; Drug Interactions; Horses; Ketamine; Reproducibility of Results; Stereoisomerism

2005
Pharmacokinetics of ketamine and its metabolite, norketamine, after intravenous administration of a bolus of ketamine to isoflurane-anesthetized dogs.
    American journal of veterinary research, 2005, Volume: 66, Issue:12

    Topics: Anesthetics, Inhalation; Animals; Chromatography, Liquid; Dogs; Injections, Intravenous; Isoflurane; Ketamine; Mass Spectrometry; Models, Biological

2005
Cardiovascular and respiratory effects of ketamine infusions in isoflurane-anesthetized dogs before and during noxious stimulation.
    American journal of veterinary research, 2005, Volume: 66, Issue:12

    Topics: Anesthesia, Inhalation; Animals; Cardiovascular System; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Hydrogen-Ion Concentration; Injections, Intravenous; Isoflurane; Ketamine; Oxygen; Oxygen Consumption

2005
On-line preconcentration and determination of ketamine and norketamine by micellar electrokinetic chromatography. Complementary method to gas chromatography/mass spectrometry.
    Journal of chromatography. A, 2006, Apr-14, Volume: 1111, Issue:2

    Topics: Chromatography, Micellar Electrokinetic Capillary; Gas Chromatography-Mass Spectrometry; Ketamine; Reproducibility of Results; Sensitivity and Specificity

2006
The effect of ketamine on intraspinal acetylcholine release: involvement of spinal nicotinic receptors.
    European journal of pharmacology, 2006, Mar-18, Volume: 534, Issue:1-3

    Topics: Acetylcholine; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Bridged Bicyclo Compounds, Heterocyclic; Isoflurane; Ketamine; Male; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Time Factors

2006
Hair analysis for ketamine and its metabolites.
    Forensic science international, 2006, Oct-16, Volume: 162, Issue:1-3

    Topics: Anesthetics, Dissociative; Chromatography, Gas; Dose-Response Relationship, Drug; Forensic Medicine; Hair; Hair Color; Humans; Ketamine; Male; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection

2006
Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion.
    Toxicology and applied pharmacology, 2006, Nov-01, Volume: 216, Issue:3

    Topics: Algorithms; Analgesics; Anesthesia; Anesthetics, Dissociative; Animals; Biotransformation; Drug Delivery Systems; Electrophysiology; Horses; Infusions, Intravenous; Ketamine; Male; Models, Statistical; Pain Measurement; Reflex; Stereoisomerism; Tissue Distribution

2006
Determination of ketamine and norketamine in hair by gas chromatography/mass spectrometry using two-step derivatization.
    Rapid communications in mass spectrometry : RCM, 2006, Volume: 20, Issue:20

    Topics: Gas Chromatography-Mass Spectrometry; Hair; Illicit Drugs; Ketamine; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection

2006
Performance characteristics of ELISAs for monitoring ketamine exposure.
    Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 379, Issue:1-2

    Topics: Anesthetics, Dissociative; Calibration; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Sensitivity and Specificity; Substance Abuse Detection

2007
GC-MS quantification of ketamine, norketamine, and dehydronorketamine in urine specimens and comparative study using ELISA as the preliminary test methodology.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Jun-01, Volume: 852, Issue:1-2

    Topics: Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Sensitivity and Specificity

2007
Analysis of ketamine and norketamine in urine by automatic solid-phase extraction (SPE) and positive ion chemical ionization-gas chromatography-mass spectrometry (PCI-GC-MS).
    Forensic science international, 2008, Jan-30, Volume: 174, Issue:2-3

    Topics: Animals; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Ketamine; Male; Rats; Rats, Sprague-Dawley; Substance Abuse Detection

2008
Enantioselective analysis of ketamine and its metabolites in equine plasma and urine by CE with multiple isomer sulfated beta-CD.
    Electrophoresis, 2007, Volume: 28, Issue:15

    Topics: Animals; beta-Cyclodextrins; Electrophoresis, Capillary; Horses; Ketamine; Stereoisomerism; Sulfates

2007
Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration in Shetland ponies sedated with xylazine.
    Veterinary journal (London, England : 1997), 2008, Volume: 177, Issue:3

    Topics: Adrenergic alpha-Agonists; Anesthesia, General; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Blood Gas Analysis; Cross-Over Studies; Horses; Ketamine; Male; Random Allocation; Stereoisomerism; Xylazine

2008
Ketamine levels in plasma and red blood cells after intravenous administration in the horse.
    Veterinary research communications, 2007, Volume: 31 Suppl 1

    Topics: Animals; Erythrocytes; Horses; Injections, Intravenous; Ketamine; Plasma

2007
Modeling the norketamine metabolite in children and the implications for analgesia.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:9

    Topics: Adult; Aged; Analgesia; Analysis of Variance; Anesthetics, Dissociative; Child; Child, Preschool; Chromatography, High Pressure Liquid; Conscious Sedation; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Ketamine; Male; Mass Spectrometry; Middle Aged; Models, Statistical; Population; Reference Standards; Reproducibility of Results; Solid Phase Extraction

2007
Simultaneous determination of ketamine, tramadol, methadone, and their metabolites in urine by gas chromatography-mass spectrometry.
    Journal of analytical toxicology, 2008, Volume: 32, Issue:3

    Topics: Analgesics; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Methadone; Narcotics; Pyrrolidines; Tramadol

2008
[Determination of ketamine and norketamine in blood and urine by high performance liquid chromatography].
    Fa yi xue za zhi, 2008, Volume: 24, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Female; Ketamine; Male; Rats; Rats, Wistar

2008
Interaction between morphine and norketamine enantiomers in rodent models of nociception.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4

    Topics: Analgesics, Opioid; Animals; Constriction, Pathologic; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Formaldehyde; Ketamine; Male; Morphine; Motor Activity; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Stereoisomerism

2008
Effects of norketamine enantiomers in rodent models of persistent pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4

    Topics: Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Formaldehyde; Hot Temperature; Hyperalgesia; Ketamine; Male; Motor Activity; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Stereotyped Behavior

2008
Plasma levels of a low-dose constant-rate-infusion of ketamine and its effect on single and repeated nociceptive stimuli in conscious dogs.
    Veterinary journal (London, England : 1997), 2009, Volume: 182, Issue:2

    Topics: Anesthetics, Dissociative; Animals; Dogs; Dose-Response Relationship, Drug; Electromyography; Infusions, Intravenous; Ketamine; Male; Nociceptors; Pain; Prospective Studies; Stereoisomerism; Transcutaneous Electric Nerve Stimulation

2009
Utility of immunoassay in drug screening in skeletal tissues: sampling considerations in detection of ketamine exposure in femoral bone and bone marrow following acute administration using ELISA.
    Journal of forensic sciences, 2008, Volume: 53, Issue:6

    Topics: Analgesics; Animals; Bone Marrow; Chromatography, Gas; Diaphyses; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epiphyses; Femur; Forensic Toxicology; Hydrogen-Ion Concentration; Ketamine; Male; Rats; Rats, Wistar; Substance Abuse Detection

2008
Detection of ketamine and its metabolites in urine by ultra high pressure liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Dec-01, Volume: 876, Issue:1

    Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Ketamine; Male; Tandem Mass Spectrometry

2008
Stereoselective biotransformation of ketamine in equine liver and lung microsomes.
    Journal of veterinary pharmacology and therapeutics, 2008, Volume: 31, Issue:5

    Topics: Analgesics; Animals; Biotransformation; Female; Horses; In Vitro Techniques; Ketamine; Lung; Male; Metabolic Clearance Rate; Microsomes, Liver; Models, Biological; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Substrate Specificity

2008
Pharmacokinetics of ketamine and its metabolite norketamine administered at a sub-anesthetic dose together with xylazine to calves prior to castration.
    Journal of veterinary pharmacology and therapeutics, 2009, Volume: 32, Issue:2

    Topics: Adrenergic alpha-Agonists; Anesthesia, Intravenous; Anesthetics, Dissociative; Animals; Cattle; Chromatography, Liquid; Drug Combinations; Ketamine; Male; Orchiectomy; Pain; Xylazine

2009
Rapid detection of ketamine and norketamine in rat hair using micropulverized extraction and ultra-performance liquid chromatography-electrospray ionization mass spectrometry.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:12

    Topics: Anesthetics, Dissociative; Animals; Chromatography, Liquid; Hair; Ketamine; Rats; Spectrometry, Mass, Electrospray Ionization

2009
Stereoselective pharmacokinetics of ketamine and norketamine after constant rate infusion of a subanesthetic dose of racemic ketamine or S-ketamine in Shetland ponies.
    American journal of veterinary research, 2009, Volume: 70, Issue:7

    Topics: Animals; Area Under Curve; Half-Life; Horses; Ketamine; Male

2009
Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier.
    Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:9

    Topics: Animals; Cells, Cultured; Cytoskeleton; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Exocytosis; Female; Glomerular Filtration Rate; Glutamic Acid; Ketamine; Kidney Diseases; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Podocytes; rab3A GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2009
CE provides evidence of the stereoselective hydroxylation of norketamine in equines.
    Electrophoresis, 2009, Volume: 30, Issue:16

    Topics: Animals; Chromatography, Liquid; Electrophoresis, Capillary; Horses; Hydroxylation; Ketamine; Mass Spectrometry; Microsomes, Liver; Stereoisomerism

2009
S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.
    Anesthesiology, 2009, Volume: 111, Issue:4

    Topics: Adolescent; Adult; Algorithms; Anesthetics, Dissociative; Cardiac Output; Dose-Response Relationship, Drug; Electric Stimulation; Endpoint Determination; Female; Hot Temperature; Humans; Hyperalgesia; Infusions, Intravenous; Ketamine; Male; Models, Statistical; Pain; Pain Measurement; Pain Threshold; Sex Characteristics; Young Adult

2009
Determination of amphetamine-type stimulants, ketamine and metabolites in fingernails by gas chromatography-mass spectrometry.
    Forensic science international, 2010, Jan-30, Volume: 194, Issue:1-3

    Topics: Amphetamines; Analgesics; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Nails; Substance Abuse Detection

2010
Rapid and simple determination of psychotropic phenylalkylamine derivatives in human hair by gas chromatography-mass spectrometry using micro-pulverized extraction.
    Forensic science international, 2010, Mar-20, Volume: 196, Issue:1-3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Hallucinogens; Humans; Ketamine; Limit of Detection; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Substance Abuse Detection

2010
Identification and quantitation of ketamine in biological matrices using gas chromatography-mass spectrometry (GC-MS).
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 603

    Topics: Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Reproducibility of Results; Solid Phase Extraction

2010
Analysis of ketamine and norketamine in hair samples using molecularly imprinted solid-phase extraction (MISPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS).
    Analytical and bioanalytical chemistry, 2010, Volume: 396, Issue:7

    Topics: Chromatography, High Pressure Liquid; Hair; Humans; Illicit Drugs; Ketamine; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection

2010
A fast screening procedure for ketamine and metabolites in urine samples with tandem mass spectrometry.
    Journal of analytical toxicology, 2010, Volume: 34, Issue:3

    Topics: Calibration; Enzyme-Linked Immunosorbent Assay; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry

2010
Alveolar but not intravenous S-ketamine inhibits alveolar sodium transport and lung fluid clearance in rats.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:1

    Topics: Anesthetics, Dissociative; Animals; Atmosphere Exposure Chambers; Body Fluids; Bronchoalveolar Lavage Fluid; Cell Separation; Cells, Cultured; Endotoxemia; Injections, Intravenous; Ketamine; Lipopolysaccharides; Lung; Male; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium Channels

2010
Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro.
    Journal of chromatography. A, 2010, Dec-17, Volume: 1217, Issue:51

    Topics: Analgesics; Biotransformation; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Humans; Hydroxylation; Ketamine; Kinetics; Microsomes, Liver; Stereoisomerism

2010
Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome.
    Chirality, 2011, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Analgesics; Chromatography, Liquid; Complex Regional Pain Syndromes; Female; Humans; Infusions, Intravenous; Ketamine; Male; Mass Spectrometry; Middle Aged; Stereoisomerism; Structure-Activity Relationship; Time Factors; Treatment Outcome; Young Adult

2011
Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs.
    Journal of pharmaceutical and biomedical analysis, 2011, Jan-05, Volume: 54, Issue:1

    Topics: Animals; Anions; Antifungal Agents; beta-Cyclodextrins; Drug Design; Electrophoresis; Electrophoresis, Capillary; Ketamine; Male; Microsomes, Liver; Models, Chemical; Rats; Stereoisomerism; Time Factors

2011
The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS.
    Forensic science international, 2011, May-20, Volume: 208, Issue:1-3

    Topics: Excitatory Amino Acid Antagonists; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Ketamine; Limit of Detection; Molecular Structure; Specimen Handling; Substance Abuse Detection

2011
Disposition of ketamine and norketamine in hair after a single dose.
    International journal of legal medicine, 2011, Volume: 125, Issue:6

    Topics: Administration, Oral; Adult; Anesthetics, Dissociative; Chromatography, Liquid; Female; Forensic Medicine; Hair; Humans; Ketamine; Tandem Mass Spectrometry

2011
[Toxicokinetics of ketamine in rabbits].
    Fa yi xue za zhi, 2010, Volume: 26, Issue:5

    Topics: Administration, Oral; Anesthetics, Dissociative; Animals; Blood Pressure; Gas Chromatography-Mass Spectrometry; Heart Rate; Ketamine; Male; Perceptual Disorders; Rabbits; Random Allocation; Time Factors

2010
Determination of amphetamine-type stimulants, cocaine and ketamine in human hair by liquid chromatography/linear ion trap-Orbitrap hybrid mass spectrometry.
    The Analyst, 2011, Sep-07, Volume: 136, Issue:17

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Chromatography, Liquid; Cocaine; Hair; Humans; Illicit Drugs; Ketamine; Limit of Detection; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Tandem Mass Spectrometry

2011
Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:6

    Topics: Administration, Oral; Anesthetics, Dissociative; Biological Availability; Biotransformation; Burns; Child; Child, Preschool; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Infusions, Intravenous; Injections, Intravenous; Ketamine; Male; Pain

2011
Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.
    Anesthesiology, 2011, Volume: 115, Issue:1

    Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Cold Temperature; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Foot Injuries; Hyperalgesia; Infrared Rays; Ketamine; Motor Activity; Neuralgia; Pain; Pain Measurement; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior

2011
Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d₄.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    Topics: Chlorobenzenes; Deuterium; Drug Design; Drug Discovery; Halogenation; Ketamine

2011
Relative distribution of ketamine and norketamine in skeletal tissues following various periods of decomposition.
    Journal of analytical toxicology, 2011, Volume: 35, Issue:7

    Topics: Animals; Bone and Bones; Calibration; Data Interpretation, Statistical; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Ketamine; Linear Models; Male; Postmortem Changes; Rats; Rats, Wistar; Reproducibility of Results; Solid Phase Extraction; Substance Abuse Detection; Time Factors; Tissue Distribution

2011
Rapid and simple GC-MS method for determination of psychotropic phenylalkylamine derivatives in nails using micro-pulverized extraction.
    Journal of forensic sciences, 2012, Volume: 57, Issue:1

    Topics: Amphetamines; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Limit of Detection; Linear Models; Nails; Substance Abuse Detection

2012
Enantioselective capillary electrophoresis for the assessment of CYP3A4-mediated ketamine demethylation and inhibition in vitro.
    Electrophoresis, 2011, Volume: 32, Issue:19

    Topics: beta-Cyclodextrins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Electrophoresis, Capillary; gamma-Cyclodextrins; Humans; Ketamine; Ketoconazole; Kinetics; Methylation; Nonlinear Dynamics; Recombinant Proteins; Stereoisomerism

2011
Cell signaling analysis by mass spectrometry under coculture conditions on an integrated microfluidic device.
    Analytical chemistry, 2011, Dec-15, Volume: 83, Issue:24

    Topics: Animals; Coculture Techniques; Dimethylpolysiloxanes; Dopamine; Growth Hormone; Ketamine; Microfluidic Analytical Techniques; PC12 Cells; Rats; Signal Transduction; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization

2011
Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans.
    American journal of veterinary research, 2011, Volume: 72, Issue:11

    Topics: Analgesics; Anesthetics, Dissociative; Animals; Antibodies, Blocking; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Electrophoresis, Capillary; Enzyme Inhibitors; Female; Horses; Humans; Ketamine; Male; Methylation; Microsomes, Liver; Species Specificity; Stereoisomerism

2011
The first international proficiency test on ketamine and norketamine in hair.
    Forensic science international, 2012, Jun-10, Volume: 219, Issue:1-3

    Topics: Anesthetics, Dissociative; Chromatography, Liquid; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Internationality; Ketamine; Laboratories

2012
Comparison of relative distribution of ketamine and norketamine in decomposed skeletal tissues following single and repeated exposures.
    Journal of analytical toxicology, 2012, Volume: 36, Issue:6

    Topics: Algorithms; Anesthetics, General; Animals; Biotransformation; Bone and Bones; Dose-Response Relationship, Drug; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Injections, Intraperitoneal; Ketamine; Male; Organ Specificity; Postmortem Changes; Rats; Rats, Wistar; Solid Phase Extraction; Tissue Distribution

2012
Stereoselective and regiospecific hydroxylation of ketamine and norketamine.
    Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:11

    Topics: Anesthetics, Dissociative; Complex Regional Pain Syndromes; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Ketamine

2012
Estimation of the measurement uncertainty in quantitative determination of ketamine and norketamine in urine using a one-point calibration method.
    Journal of analytical toxicology, 2012, Volume: 36, Issue:7

    Topics: Calibration; Chromatography, Gas; Humans; Ketamine; Substance Abuse Detection; Uncertainty

2012
Electrophoretically mediated microanalysis for characterization of the enantioselective CYP3A4 catalyzed N-demethylation of ketamine.
    Electrophoresis, 2012, Volume: 33, Issue:22

    Topics: Cytochrome P-450 CYP3A; Electrophoresis, Capillary; Equipment Design; Humans; Ketamine; Kinetics; Methylation; NADP; Nonlinear Dynamics; Stereoisomerism

2012
Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit.
    Neurotoxicology, 2012, Volume: 33, Issue:5

    Topics: Adjuvants, Immunologic; Animals; Biophysics; Calcium; Cell Differentiation; Cell Line; Diterpenes; Electric Stimulation; Electroporation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ketamine; Large-Conductance Calcium-Activated Potassium Channels; Lithium Chloride; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Time Factors; Transfection

2012
Determination of ketamine and norketamine in hair by micropulverized extraction and liquid chromatography-high resolution mass spectrometry.
    Forensic science international, 2013, Mar-10, Volume: 226, Issue:1-3

    Topics: Adolescent; Adult; Anesthetics, Dissociative; Chromatography, Liquid; Female; Forensic Toxicology; Hair; Humans; Ketamine; Limit of Detection; Male; Mass Spectrometry; Substance Abuse Detection; Substance-Related Disorders

2013
Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry.
    The Analyst, 2013, Apr-21, Volume: 138, Issue:8

    Topics: Humans; Illicit Drugs; Ketamine; Saliva; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Substance-Related Disorders

2013
Compounded ointment results in severe toxicity in a pediatric patient.
    Pediatric emergency care, 2013, Volume: 29, Issue:11

    Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined Modality Therapy; Consciousness Disorders; Cyclohexanecarboxylic Acids; Diaper Rash; Drug Combinations; Drug Compounding; Drug Overdose; Emergencies; Gabapentin; gamma-Aminobutyric Acid; Humans; Imipramine; Infant; Intensive Care Units, Pediatric; Intubation, Intratracheal; Ketamine; Lidocaine; Male; Mefenamic Acid; Ointments; Reflex, Abnormal; Respiration Disorders; Skin Absorption

2013
Estimating daily and diurnal variations of illicit drug use in Hong Kong: a pilot study of using wastewater analysis in an Asian metropolitan city.
    Forensic science international, 2013, Dec-10, Volume: 233, Issue:1-3

    Topics: Chromatography, Liquid; Cocaine; Hong Kong; Humans; Ketamine; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Pilot Projects; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry; Time Factors; Urban Population; Wastewater

2013
Ketamine and the metabolite norketamine: persistence and phototransformation toxicity in hospital wastewater and surface water.
    Water research, 2014, Apr-15, Volume: 53

    Topics: Aliivibrio fischeri; Chromatography, Liquid; Environmental Monitoring; Fresh Water; Hospitals; Ketamine; Lethal Dose 50; Photolysis; Taiwan; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical

2014
Development of a method for analysis of ketamine and norketamine enantiomers in equine brain and cerebrospinal fluid by capillary electrophoresis.
    Electrophoresis, 2014, Volume: 35, Issue:19

    Topics: Animals; Brain Chemistry; Electrophoresis, Capillary; Horses; Ketamine; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism

2014
Determination of ketamine, norketamine and dehydronorketamine in urine by hollow-fiber liquid-phase microextraction using an essential oil as supported liquid membrane.
    Forensic science international, 2014, Volume: 243

    Topics: Anesthetics, Dissociative; Eucalyptus; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydrochloric Acid; Ketamine; Limit of Detection; Liquid Phase Microextraction; Plant Oils

2014
Ketamine metabolomics in the treatment of major depression.
    Anesthesiology, 2014, Volume: 121, Issue:1

    Topics: Animals; Excitatory Amino Acid Antagonists; Ketamine; Male; TOR Serine-Threonine Kinases

2014
(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.
    Anesthesiology, 2014, Volume: 121, Issue:1

    Topics: Aconitine; Animals; Blotting, Western; Brain; Excitatory Amino Acid Antagonists; Ketamine; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Phosphorylation; Prefrontal Cortex; Rats; Rats, Wistar; Signal Transduction; TOR Serine-Threonine Kinases

2014
Enhancing ketamine translational pharmacology via receptor occupancy normalization.
    Neuropharmacology, 2014, Volume: 86

    Topics: Animals; Depression; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ketamine; Macaca fascicularis; Male; Memory; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Species Specificity; Tritium

2014
The influence of body position and microclimate on ketamine and metabolite distribution in decomposed skeletal remains.
    Journal of analytical toxicology, 2014, Volume: 38, Issue:8

    Topics: Animals; Bone and Bones; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Ketamine; Male; Microclimate; Postmortem Changes; Posture; Rats; Rats, Wistar; Reproducibility of Results; Solid Phase Extraction

2014
Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat.
    British journal of pharmacology, 2015, Volume: 172, Issue:11

    Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Drug Tolerance; Injections, Subcutaneous; Ketamine; Liver; Morphine; Morphine Derivatives; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2015
What is hydroxynorketamine and what can it bring to neurotherapeutics?
    Expert review of neurotherapeutics, 2014, Volume: 14, Issue:11

    Topics: Animals; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Humans; Ketamine; Rats

2014
Cut-off proposal for the detection of ketamine in hair.
    Forensic science international, 2015, Volume: 248

    Topics: Adolescent; Adult; Anesthetics, Dissociative; Chromatography, High Pressure Liquid; Female; Forensic Toxicology; Hair; Humans; Ketamine; Male; Mass Spectrometry; Substance Abuse Detection; Substance-Related Disorders; Young Adult

2015
Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:4

    Topics: Administration, Oral; Adult; Analgesics; Chronic Pain; Healthy Volunteers; Humans; Infusions, Intravenous; Ketamine; Young Adult

2015
Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs.
    Anesthesia and analgesia, 2015, Volume: 121, Issue:4

    Topics: Animals; Drug Discovery; Female; Hypnotics and Sedatives; Ketamine; Male; Rabbits; Rats; Rats, Sprague-Dawley; Reflex, Righting

2015
Antidepressant-like effects of ketamine, norketamine and dehydronorketamine in forced swim test: Role of activity at NMDA receptor.
    Neuropharmacology, 2015, Volume: 99

    Topics: Administration, Oral; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketamine; Male; Mice; Motor Activity; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Swimming; Tritium

2015
Determination of ketamine and its major metabolite, norketamine, in urine and plasma samples using microextraction by packed sorbent and gas chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, Nov-01, Volume: 1004

    Topics: Calibration; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Limit of Detection; Reference Standards; Tandem Mass Spectrometry

2015
Physiological and pharmacokinetic effects of multilevel caging on Sprague Dawley rats under ketamine-xylazine anesthesia.
    Experimental animals, 2016, Nov-01, Volume: 65, Issue:4

    Topics: Anesthetics, Dissociative; Animals; Half-Life; Housing, Animal; Hypnotics and Sedatives; Ketamine; Male; Rats; Rats, Sprague-Dawley; Reflex; Specific Pathogen-Free Organisms; Xylazine

2016
Chiral separation and determination of ketamine and norketamine in hair by capillary electrophoresis.
    Forensic science international, 2016, Volume: 266

    Topics: Electrophoresis, Capillary; Forensic Sciences; Hair; Humans; Ketamine; Liquid-Liquid Extraction; Stereoisomerism

2016
Validation of a SPE-LC-MS/MS method for the determination of ketamine and norketamine in micropulverized hair after a single IV dose.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Oct-15, Volume: 1033-1034

    Topics: Adult; Aged; Calibration; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Hair; Humans; Injections, Intravenous; Ketamine; Limit of Detection; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry

2016
Simulation and experimental study of enzyme and reactant mixing in capillary electrophoresis based on-line methods.
    Journal of chromatography. A, 2016, Nov-04, Volume: 1471

    Topics: Buffers; Computer Simulation; Cytochrome P-450 CYP3A; Diffusion; Electrophoresis, Capillary; Enzyme Assays; Hydrodynamics; Ketamine

2016
Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples.
    Journal of pharmaceutical and biomedical analysis, 2017, May-30, Volume: 139

    Topics: Adult; Chromatography, Liquid; Feces; Humans; Ketamine; Male; Pilot Projects; Stereoisomerism; Tandem Mass Spectrometry

2017
Ecotoxicological effect of ketamine: Evidence of acute, chronic and photolysis toxicity to Daphnia magna.
    Ecotoxicology and environmental safety, 2017, Volume: 143

    Topics: Animals; Daphnia; Ketamine; Lethal Dose 50; Photolysis; Reproduction; Toxicity Tests, Acute; Toxicity Tests, Chronic; Water Pollutants, Chemical

2017
Evaluation of in-sewer transformation of selected illicit drugs and pharmaceutical biomarkers.
    The Science of the total environment, 2017, Dec-31, Volume: 609

    Topics: Biofilms; Biomarkers; Carbamazepine; Codeine; Environmental Monitoring; Illicit Drugs; Ketamine; Methamphetamine; Sewage; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical

2017
Determination of ketamine and its main metabolites by liquid chromatography coupled to tandem mass spectrometry in pig plasma: Comparison of extraction methods.
    Journal of pharmaceutical and biomedical analysis, 2017, Nov-30, Volume: 146

    Topics: Animals; Chromatography, Liquid; Ketamine; Liquid-Liquid Extraction; Plasma; Reproducibility of Results; Solid Phase Extraction; Swine; Tandem Mass Spectrometry

2017
Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection.
    Journal of pharmaceutical and biomedical analysis, 2017, Nov-30, Volume: 146

    Topics: Antidepressive Agents; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Depressive Disorder, Major; Humans; Hydroxylation; Ketamine; Solvents

2017
Ketamine and norketamine stability in whole blood at ambient and 4°C conditions.
    Biomedical chromatography : BMC, 2018, Volume: 32, Issue:3

    Topics: Chromatography, Liquid; Drug Stability; Humans; Hydrophobic and Hydrophilic Interactions; Ketamine; Linear Models; Reproducibility of Results; Temperature

2018
A rapid and sensitive chiral LC-MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine.
    Journal of pharmaceutical and biomedical analysis, 2018, Jan-30, Volume: 148

    Topics: Animals; Antidepressive Agents; Brain; Calibration; Cerebrospinal Fluid; Chromatography, Liquid; Ketamine; Male; Mice; Mice, Inbred C57BL; Plasma; Reproducibility of Results; Stereoisomerism; Substance Abuse Detection; Tandem Mass Spectrometry

2018
Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.
    The international journal of neuropsychopharmacology, 2018, 01-01, Volume: 21, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Helplessness, Learned; Ketamine; Male; Off-Label Use; Rats; Spermidine; Time Factors

2018
Neurocognitive and behavioural performance of healthy volunteers receiving an increasing analgesic-range infusion of ketamine.
    Psychopharmacology, 2018, Volume: 235, Issue:4

    Topics: Adult; Analgesics; Behavior; Cognition; Female; Humans; Infusions, Intravenous; Ketamine; Male; Memory, Short-Term; Psychomotor Performance; Reaction Time; Young Adult

2018
Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro.
    Electrophoresis, 2018, Volume: 39, Issue:12

    Topics: Animals; Dogs; Electrophoresis, Capillary; Glucuronosyltransferase; Horses; Humans; Ketamine; Microsomes, Liver; Species Specificity; Stereoisomerism

2018
Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability.
    British journal of anaesthesia, 2018, Volume: 120, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Ketamine; Male; Models, Animal; Morphine; Oxycodone; Rats; Rats, Sprague-Dawley

2018
Computer simulation of the enantioselective separation of weak bases in an online capillary electrophoresis based microanalysis configuration comprising sulfated cyclodextrin as selector.
    Electrophoresis, 2018, Volume: 39, Issue:12

    Topics: Computer Simulation; Electrophoresis, Capillary; gamma-Cyclodextrins; Ketamine; Stereoisomerism

2018
(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:9

    Topics: Animals; Antidepressive Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depressive Disorder; Inflammation; Ketamine; Lipopolysaccharides; Male; Mice, Inbred C57BL; Mice, Inbred ICR

2018
The effect of route of administration on the enantioselective pharmacokinetics of ketamine and norketamine in rats.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:10

    Topics: Animals; Antidepressive Agents; Area Under Curve; Chromatography, Liquid; Infusions, Intravenous; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tandem Mass Spectrometry

2018
AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine.
    Biological psychiatry, 2018, 10-15, Volume: 84, Issue:8

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Dendritic Spines; Depression; Hippocampus; Ketamine; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stress, Psychological

2018
[Concentrations of Ketamine and Norketamine in the Water Environment in Beijing].
    Huan jing ke xue= Huanjing kexue, 2016, Jul-08, Volume: 37, Issue:7

    Topics: Beijing; Chromatography, High Pressure Liquid; Environmental Monitoring; Ketamine; Rivers; Sewage; Tandem Mass Spectrometry; Water Pollutants, Chemical

2016
Synthesis of carbon-14 labeled ketamine and norketamine.
    Journal of labelled compounds & radiopharmaceuticals, 2018, Volume: 61, Issue:11

    Topics: Carbon Radioisotopes; Chemistry Techniques, Synthetic; Copper; Cyanides; Isotope Labeling; Ketamine; Stereoisomerism

2018
Is (S)-norketamine an alternative antidepressant for esketamine?
    European archives of psychiatry and clinical neuroscience, 2019, Volume: 269, Issue:7

    Topics: Animals; Antidepressive Agents; Depression; Humans; Ketamine

2019
Sex Differences in the Pharmacokinetics of Low-dose Ketamine in Plasma and Brain of Male and Female Rats.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:3

    Topics: Animals; Brain; Estrogens; Female; Ketamine; Male; Plasma; Progesterone; Rats; Rats, Sprague-Dawley; Sex Characteristics

2018
Mechanisms of the Antidepressant Effects of Ketamine Enantiomers and Their Metabolites.
    Biological psychiatry, 2018, 10-15, Volume: 84, Issue:8

    Topics: Antidepressive Agents; Ketamine; Receptors, AMPA; Stereoisomerism

2018
Efficacy of the ketamine metabolite (2R,6R)-hydroxynorketamine in mice models of pain.
    Regional anesthesia and pain medicine, 2019, Volume: 44, Issue:1

    Topics: Animals; Disease Models, Animal; Female; Ketamine; Mice; Mice, Inbred C57BL; Neuralgia; Treatment Outcome

2019
Rapid electrophoretic monitoring of the anaesthetic ketamine and its metabolite norketamine in rat blood using a contactless conductivity detector to study the pharmacokinetics.
    Journal of separation science, 2019, Volume: 42, Issue:11

    Topics: Anesthetics; Animals; Electric Conductivity; Ketamine; Limit of Detection; Male; Rats; Rats, Wistar

2019
Sex-dependent changes in ketamine-induced locomotor activity and ketamine pharmacokinetics in preweanling, adolescent, and adult rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2019, Volume: 29, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Dopamine; Excitatory Amino Acid Antagonists; Female; Hippocampus; Humans; Ketamine; Locomotion; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Sex Characteristics

2019
A validated GC-MS method for ketamine and norketamine in hair and its use in authentic cases.
    Forensic science international, 2019, Volume: 301

    Topics: Adult; Anesthetics, Dissociative; Gas Chromatography-Mass Spectrometry; Hair; Humans; Ketamine; Limit of Detection; Substance Abuse Detection; Substance-Related Disorders; Young Adult

2019
MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling.
    Psychopharmacology, 2020, Volume: 237, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Intranasal; Anesthetics, Dissociative; Animals; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Ketamine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Neostriatum; Neuroprotective Agents; Parkinson Disease; Protein-Tyrosine Kinases; Receptor, trkB; Signal Transduction; Substantia Nigra; Tyrosine 3-Monooxygenase

2020
Simultaneous quantitative LC-MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapy.
    Journal of pharmaceutical and biomedical analysis, 2020, Jan-30, Volume: 178

    Topics: Amines; Calibration; Chromatography, High Pressure Liquid; Extracorporeal Membrane Oxygenation; Humans; Ketamine; Midazolam; Reproducibility of Results; Tandem Mass Spectrometry

2020
Online Enantioselective Capillary Electrophoretic Method for Screening Cytochrome P450 3A4 Inhibitors.
    Methods in molecular biology (Clifton, N.J.), 2020, Volume: 2089

    Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Electrophoresis, Capillary; Humans; Ketamine; Kinetics; Mass Screening; Stereoisomerism

2020
(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 191

    Topics: Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Female; Ketamine; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate

2020
Pharmacokinetics of ketamine following a short intravenous infusion to isoflurane-anesthetized New Zealand White rabbits (Oryctolagus cuniculus).
    Veterinary anaesthesia and analgesia, 2020, Volume: 47, Issue:3

    Topics: Analgesics; Anesthetics, Inhalation; Animals; Female; Infusions, Intravenous; Isoflurane; Ketamine; Prospective Studies; Rabbits

2020
A Fast and Validated High Throughput Bar Adsorptive Microextraction (HT-BAµE) Method for the Determination of Ketamine and Norketamine in Urine Samples.
    Molecules (Basel, Switzerland), 2020, Mar-22, Volume: 25, Issue:6

    Topics: Adsorption; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Limit of Detection; Liquid Phase Microextraction; Reproducibility of Results; Solid Phase Microextraction; Solvents; Urine; Water

2020
Structure-Activity Relationships for the Anaesthetic and Analgaesic Properties of Aromatic Ring-Substituted Ketamine Esters.
    Molecules (Basel, Switzerland), 2020, Jun-26, Volume: 25, Issue:12

    Topics: Analgesics; Anesthetics; Animals; Cyclohexanes; Down-Regulation; Esters; Inhibitory Concentration 50; Ketamine; Molecular Structure; Oximes; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

2020
Postmortem redistribution of ketamine in ocular matrices: A study of forensic relevance.
    Legal medicine (Tokyo, Japan), 2020, Volume: 47

    Topics: Animals; Aqueous Humor; Chromatography, Liquid; Female; Forensic Medicine; Goats; Injections, Intravenous; Intravitreal Injections; Ketamine; Male; Models, Animal; Postmortem Changes; Rabbits; Tandem Mass Spectrometry; Vitreous Body

2020
Determination of Ketamine and Norketamine in Hair and Evaluation of Polydrug Use in Ketamine Abusers Using Hair Analysis in Korea.
    Journal of analytical toxicology, 2021, Nov-09, Volume: 45, Issue:9

    Topics: Hair Analysis; Humans; Ketamine; Republic of Korea; Substance Abuse Detection

2021
Ketamine and Norketamine: Enantioresolution and Enantioselective Aquatic Ecotoxicity Studies.
    Environmental toxicology and chemistry, 2022, Volume: 41, Issue:3

    Topics: Animals; Chromatography, Liquid; Daphnia; Ketamine; Stereoisomerism

2022
Effects of long-term alcohol exposure on the pharmacokinetic profiles of ketamine and norketamine in rats.
    Alcohol (Fayetteville, N.Y.), 2021, Volume: 96

    Topics: Alcoholism; Animals; Chromatography, Liquid; Humans; Ketamine; Rats; Tandem Mass Spectrometry

2021
Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers.
    European journal of clinical pharmacology, 2021, Volume: 77, Issue:8

    Topics: Adult; Female; Healthy Volunteers; Humans; Ketamine; Male; Models, Biological; Reproducibility of Results; Young Adult

2021
Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses.
    Scientific reports, 2021, 05-05, Volume: 11, Issue:1

    Topics: Adult; Apolipoprotein A-I; Female; Humans; Ketamine; Male; Proteomics; Substance-Related Disorders; Urinary Bladder; Young Adult

2021
A critical point in chiral chromatography-mass spectrometry analysis of ketamine metabolites.
    Drug testing and analysis, 2021, Volume: 13, Issue:9

    Topics: Animals; Chromatography, Liquid; Dogs; Ketamine; Stereoisomerism; Tandem Mass Spectrometry

2021
Ketamine for Refractory Chronic Migraine: An Observational Pilot Study and Metabolite Analysis.
    Journal of clinical pharmacology, 2021, Volume: 61, Issue:11

    Topics: Adult; Analgesics; Chronic Disease; Female; Humans; Ketamine; Lidocaine; Male; Middle Aged; Migraine Disorders; Pilot Projects; Prospective Studies; Young Adult

2021
Gut microbiota is involved in the antidepressant-like effect of (S)-norketamine in an inflammation model of depression.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 207

    Topics: Animals; Antidepressive Agents; Bacteria; Depression; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation; Ketamine; Lipopolysaccharides; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate

2021
Identification of a novel norketamine precursor from seized powders: 2-(2-chlorophenyl)-2-nitrocyclohexanone.
    Forensic science international, 2022, Volume: 333

    Topics: Cyclohexanones; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Powders

2022
Microextraction by Packed Sorbent as a Clean-up Approach for the Determination of Ketamine and Norketamine in Hair by Gas Chromatography--Tandem Mass Spectrometry.
    Journal of analytical toxicology, 2023, Mar-24, Volume: 47, Issue:3

    Topics: Gas Chromatography-Mass Spectrometry; Hair; Ketamine; Limit of Detection; Reproducibility of Results; Solid Phase Microextraction; Tandem Mass Spectrometry

2023
Chiral LC-MS/MS method for the simultaneous determination of (R,S)-ketamine, (R,S)-norketamine, and (2R,6R;2S,6S)-hydroxynorketamine in mouse plasma and brain.
    Journal of pharmaceutical and biomedical analysis, 2023, Feb-05, Volume: 224

    Topics: Animals; Antidepressive Agents; Brain; Chromatography, Liquid; Ketamine; Mice; Tandem Mass Spectrometry

2023
Simultaneous quantitation of ketamine, norketamine and dehydronorketamine in human milk using a novel ultra high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) assay.
    Journal of pharmaceutical and biomedical analysis, 2023, Sep-20, Volume: 234

    Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; Ketamine; Lactation; Milk, Human; Reproducibility of Results; Tandem Mass Spectrometry

2023