norketamine has been researched along with ketamine in 204 studies
Studies (norketamine) | Trials (norketamine) | Recent Studies (post-2010) (norketamine) | Studies (ketamine) | Trials (ketamine) | Recent Studies (post-2010) (ketamine) |
---|---|---|---|---|---|
220 | 32 | 122 | 15,029 | 2,321 | 6,678 |
Protein | Taxonomy | norketamine (IC50) | ketamine (IC50) |
---|---|---|---|
Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 4.216 | |
Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 4.216 | |
Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 5.02 | |
Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 5.02 | |
Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 3.7762 | |
Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 3.5563 | |
Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | 4.1059 | |
Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 5.02 | |
Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 5.02 | |
Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 5.02 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (6.37) | 18.7374 |
1990's | 16 (7.84) | 18.2507 |
2000's | 46 (22.55) | 29.6817 |
2010's | 101 (49.51) | 24.3611 |
2020's | 28 (13.73) | 2.80 |
Authors | Studies |
---|---|
Baillie, TA; Leung, LY | 2 |
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR | 1 |
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR | 1 |
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR | 1 |
Kharasch, ED; Labroo, R | 1 |
Brune, K; Geisslinger, G; Kamp, HD; Menzel-Soglowek, S | 1 |
Calvo, MB; Dominguez-Gil, A; Gascon, AR; Hernandez, R; Muriel, C; Pedraz, JL; Torres, LM | 1 |
Courtot, D; Delatour, P; Fau, D; Jaussaud, P | 1 |
Fassbender, CP; Ganter, M; Löscher, W | 1 |
Calvo, MB; Domínguez-Gil, A; Lanao, JM; Muriel, C; Pedraz, JL; Santos Lamas, J | 1 |
Calvo, MB; Domínguez-Gil, A; Hernández-Arbeiza, J; Lanao, JM; Muriel, C; Pedraz, JL | 1 |
Adams, JD; Woolf, TF | 1 |
Hondo, T; Hoshino, T; Saito, M; Senda, M; Tohei, S | 1 |
Clements, JA; Grant, IS; McNicol, LR; Nimmo, WS | 1 |
Waterman, AE | 1 |
Hall, GM; Lacoumenta, S; Paterson, JL; Walsh, ES; Ward, I; Waterman, AE | 1 |
Dayton, PG; Hug, CC; Perel, JM; Stiller, RL | 1 |
Holasek, J; Idvall, J; Stenberg, P | 1 |
Davisson, JN; Hong, SC | 1 |
Adams, JD; Baillie, TA; Castagnoli, N; Trevor, AJ | 1 |
Breivik, H; Eide, PK; Stubhaug, A; Øye, I | 1 |
Bushnell, TG; Craig, J | 1 |
Akeson, J; Björkman, S; Messeter, K; Rośen, I | 1 |
Akeson, J; Björkman, S; Helfer, M; Messeter, K; Rosén, I | 1 |
Hartvig, P; Joachimsson, PO; Larsson, E | 1 |
Flaherty, D; McCormack, R; Monteiro, AM; Nolan, A; Reid, J; Welsh, E | 1 |
Gustafsson, LL; Svensson, JO | 1 |
Cozian, A; Lepage, JY; Malinovsky, JM; Pinaud, M; Servin, F | 1 |
Borgbjerg, FM; Ebert, B; Mikkelsen, S; Thorkildsen, C | 1 |
Bolze, S; Boulieu, R | 1 |
Elliott, KJ; Gorman, AL; Inturrisi, CE; Shimoyama, M; Shimoyama, N | 1 |
Aoyama, T; Iga, T; Kariya, S; Ohtani, M; Uchino, K; Yamamura, Y; Yanagihara, Y | 1 |
Bolon, M; Boulieu, R; Hijazi, Y | 1 |
Edwards, SR; Mather, LE | 1 |
Jacobs, AJ; Levine, B; Moore, KA; Sklerov, J | 1 |
Boulieu, R; Hijazi, Y | 1 |
Aoyama, T; Ashizawa, N; Hiraishi, T; Iga, T; Kariya, S; Ohtani, M; Uchino, K; Yamada, Y; Yamamura, Y; Yanagihara, Y | 1 |
Bodonian, C; Bolon, M; Boulieu, R; Hijazi, Y; Salord, F | 1 |
Patel, S; Rodriguez Rosas, ME; Wainer, IW | 1 |
Chou, SL; Giang, YS; Ling, YC; Yang, MH | 1 |
Lin, HR; Lua, AC | 1 |
Cheng, SG; Shih, TS; Wang, KC | 1 |
Biallas, R; Gruber, M; Weber, F; Wulf, H | 1 |
Adamowicz, P; Juhascik, MP; Moore, CM; Negrusz, A; Saini, BK; Schlemmer, RF; Webster, DE | 1 |
Huang, MK; Huang, SD; Li, JH; Liu, C | 1 |
Knobloch, M; Larenza, P; Levionnois, O; Mevissen, M; Theurillat, R; Thormann, W | 1 |
Ilkiw, JE; Pypendop, BH | 1 |
Boscan, P; Ilkiw, JE; Pypendop, BH; Solano, AM | 1 |
Hsieh, YZ; Jen, HP; Su, HL; Tsai, YC | 1 |
Abelson, KS; Goldkuhl, RR; Höglund, AU; Nylund, A | 1 |
Shen, M; Xiang, P; Zhuo, X | 1 |
Knobloch, M; Levionnois, OL; Mevissen, M; Portier, CJ; Spadavecchia, C; Theurillat, R; Thormann, W | 1 |
In, MK; Kim, JH; Kim, JY | 1 |
Knobloch, M; Kronen, PW; Landoni, MF; Larenza, MP; Levionnois, OL; Schatzmann, U; Theurillat, R; Thormann, W | 2 |
Huang, MH; Lee, HH; Liu, RH; Tsai, JL; Wu, CH; Wu, MY | 1 |
Cheng, PS; Chien, CS; Fu, CY; Lee, CH; Liu, C | 1 |
Choi, SK; Chung, HS; Kim, EM; Lee, JS; Lim, MA | 1 |
Knobloch, M; Lassahn, PG; Mevissen, M; Schmitz, A; Theurillat, R; Thormann, W | 1 |
di Fabio, P; Nigro, V; Romagnoli, N; Roncada, P; Spadari, A; Zaghini, A | 1 |
Anderson, BJ; Herd, DW; Holford, NH | 1 |
Cheng, PS; Chien, CS; Lee, CH; Liu, C | 1 |
Chen, LL; He, R; Huang, LY; Li, WJ; Lia, OL; Ma, XN; Yan, YY; Yang, L | 1 |
Crooks, PA; Holtman, JR; Johnson-Hardy, J; Wala, EP | 1 |
Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP | 1 |
Andersen, OK; Arendt-Nielsen, L; Bergadano, A; Spadavecchia, C; Theurillat, R; Thormann, W | 1 |
Grummett, SA; VandenBoer, TC; Watterson, JH | 1 |
Braithwaite, RA; Cowan, DA; Elliott, SP; Halket, JM; Kicman, AT; Osselton, MD; Parkin, MC; Smith, NW; Turfus, SC | 1 |
Mevissen, M; Portier, CJ; Schmitz, A; Theurillat, R; Thormann, W | 1 |
Apley, MD; Coetzee, JF; Gehring, R; Tarus-Sang, J | 1 |
Chong, C; Ilett, KF; Jenkins, B; Page-Sharp, M; Schug, SA | 1 |
Braithwaite, RA; Cowan, DA; Elliot, SP; Halket, JM; Kicman, AT; Parkin, MC; Smith, NW; Steventon, GB; Turfus, SC | 1 |
Fukushima, T; Inagaki, S; Makino, H; Min, JZ; Toyo'oka, T | 1 |
Landoni, MF; Larenza, MP; Levionnois, OL; Peterbauer, C; Schatzmann, U; Spadavecchia, C; Thormann, W | 1 |
Armelloni, S; Berra, S; Carraro, M; Corbelli, A; Giardino, L; Guerrot, D; Ikehata, M; Li, M; Mattinzoli, D; Messa, P; Rastaldi, MP; Tourrel, F; Zennaro, C | 1 |
Lassahn, PG; Mevissen, M; Schmitz, A; Theurillat, R; Thormann, W | 1 |
Azad, SC; Beyer, A; Huge, V; Lauchart, M; Magerl, W; Schelling, G; Thieme, D | 1 |
Bauer, M; Dahan, A; Kest, B; Mooren, R; Olofsen, E; Sarton, E; Sigtermans, M | 1 |
In, MK; Kim, JY; Shin, SH | 1 |
Balikova, M; Brunovsky, M; Bubenikova-Valesova, V; Horacek, J; Hoschl, C; Koprivova, J; Mohr, P; Novak, T; Palenicek, T; Spaniel, F; Tislerova, B | 1 |
In, MK; Kim, JY; Lee, JI; Shin, SH | 1 |
Cox, K; Gamble, M; Rohrig, TP | 1 |
Anderson, RA; Cormack, PA; Harun, N | 1 |
Lee, SF; Lin, HL; Lin, HR; Liu, C; Lua, AC | 1 |
Bärtsch, P; Berger, MM; Dahan, A; Hollmann, MW; Mairbäurl, H; Pitzer, B; Schultz, MJ; Vlaar, AP; Wieland, CW; Zügel, S | 1 |
Kwan, HY; Mevissen, M; Portmann, S; Schmitz, A; Theurillat, R; Thormann, W | 1 |
Goldberg, ME; Mager, DE; Schwartzman, RJ; Torjman, MC; Wainer, IW | 1 |
Bodoki, E; Chiap, P; Crommen, J; Fillet, M; Gillotin, F; Rousseau, A; Servais, AC | 1 |
Choi, RC; Dong, TT; Fu, Q; Lau, DT; Leung, KW; Ng, WY; Ting, AK; Tsim, KW; Wang, T; Wong, ZC; Zhu, KY | 1 |
Shen, B; Shen, M; Sun, Q; Xiang, P | 1 |
Jia, J; Liu, L; Wang, YJ; Wei, ZW | 1 |
Inoue, H; Miyaguchi, H | 1 |
Anderson, BJ; Brunette, KE; Herd, DW; Schulein, S; Thomas, J; Wiesner, L | 1 |
Aarts, L; Dahan, A; Kharasch, E; Mooren, R; Niesters, M; Noppers, I; Olofsen, E; Sarton, E | 1 |
Aarts, L; Dahan, A; Morariu, A; Niesters, M; Swartjes, M | 1 |
Hagelberg, NM; Laine, K; Neuvonen, PJ; Olkkola, KT; Peltoniemi, MA; Saari, TI | 2 |
Hagelberg, NM; Laine, K; Neuvonen, PJ; Olkkola, KT; Peltoniemi, MA; Reponen, P; Saari, TI; Turpeinen, M | 1 |
Chen, C; Lin, HR; Lua, AC; Sulake, RS | 1 |
Donohue, JP; Watterson, JH | 1 |
Cheong, JC; In, MK; Kim, JY; Lee, JI; Son, JH | 1 |
Kwan, HY; Thormann, W | 1 |
Li, H; Lin, JM; Mao, S; Wei, H | 1 |
Mevissen, M; Mössner, LD; Schmitz, A; Theurillat, R; Thormann, W | 1 |
Brutsche, NE; Ibrahim, L; Luckenbaugh, DA; Mager, DE; Moaddel, R; Venkata, SL; Wainer, IW; Zarate, CA; Zhao, X | 1 |
Brutsche, N; Diazgranados, N; Franco-Chaves, J; Henter, ID; Ibrahim, L; Kronstein, P; Luckenbaugh, DA; Manji, HK; Moaddel, R; Wainer, I; Zarate, CA | 1 |
Cheng, JY; Cheung, ST; Lee, VW; Sin, DW; Wong, YC | 1 |
Brutsche, NE; Cornwell, BR; Furey, M; Grillon, C; Marquardt, CA; Salvadore, G; Zarate, CA | 1 |
Betit, CC; Donohue, JP; Watterson, JH | 1 |
Desta, Z; Goldberg, ME; Moaddel, R; Ogburn, ET; Ramamoorthy, A; Sanghvi, M; Torjman, MC; Venkata, SL; Wainer, IW; Xu, C | 1 |
Hagelberg, NM; Kurkinen, KJ; Laine, K; Neuvonen, PJ; Olkkola, KT; Peltoniemi, MA; Saari, TI | 1 |
Aarts, L; Dahan, A; Kharasch, E; Niesters, M; Noppers, I; Olofsen, E; Sarton, E | 1 |
Chang, YZ; Her, GR; Hung, SH; Liu, CR; Ma, YC; Wang, CW | 1 |
Akhlaghi, F; Linakis, JG; Machan, JT; Steele, DW; Tsze, DS | 1 |
Dahan, A; Niesters, M | 1 |
Aarts, L; Dahan, A; Khalili-Mahani, N; Martini, C; Niesters, M; Rombouts, S; van Buchem, MA; van Gerven, J | 1 |
Thormann, W; Ying Kwan, H | 1 |
Chen, SJ; Huang, MH; Lin, KH; Shen, AY; Wu, FT; Wu, SN | 1 |
Favretto, D; Ferrara, SD; Nalesso, A; Stocchero, G; Terranova, C; Tucci, M; Vogliardi, S | 1 |
Hu, B; Ng, TT; So, PK; Wang, H; Yao, ZP | 1 |
Holland, MG; Marraffa, JM; Ryzewski, M; Sullivan, RW | 1 |
Bruno, R; Carter, S; Lai, FY; Lam, PK; Leung, HW; Mueller, JF; Ort, C; Thai, PK; Thompson, K | 1 |
Lee, WN; Lin, AY; Wang, XH | 1 |
Bettschart-Wolfensberger, R; Feige, K; Larenza, MP; Theurillat, R; Thormann, W | 1 |
Almeida, RM; Bairros, AV; Lanaro, R; Yonamine, M | 1 |
Brallier, JW; Charney, DS; Feder, A; Iosifescu, DV; Lapidus, KA; Levitch, CF; Murrough, JW; Parides, MK; Perez, AM; Soleimani, L | 1 |
Dahan, A; van Velzen, M | 1 |
Bernier, M; Green, CE; Khadeer, M; Moaddel, R; O'Loughlin, K; Paul, RK; Sanghvi, M; Singh, NS; Torjman, MC; Wainer, IW | 1 |
Liu, J; Osgood, SM; Shaffer, CL; Smith, DL; Trapa, PE | 1 |
Cornthwaite, HM; Watterson, JH | 1 |
Jokinen, V; Kalso, EA; Lilius, TO; Neuvonen, MS; Niemi, M; Rauhala, PV | 1 |
Bernier, M; Moaddel, R; Singh, NS; Wainer, IW; Zarate, CA | 1 |
Di Corcia, D; Diana, P; Gerace, E; Malvaso, V; Romeo, M; Salomone, A; Vincenti, M | 1 |
Backman, JT; Fanta, S; Kalso, E; Kinnunen, M | 1 |
Denny, W; Gamage, S; Harvey, M; Jose, J; Liyanage, S; Pruijn, F; Sleigh, J; Voss, L | 1 |
Drabik, U; Gajdosz, R; Librowski, T; Nowak, G; Popik, P; Sałat, K; Siwek, A; Starowicz, G | 1 |
Barroso, M; Cruz, A; Gallardo, E; Martinho, A; Moreno, I | 1 |
Hagelberg, NM; Olkkola, KT; Peltoniemi, MA; Saari, TI | 1 |
Beaudry, F; Chevrette, J; Dodelet-Devillers, A; Gourdon, J; Hélie, P; Vachon, P; Zullian, C | 1 |
Bortolotti, F; De Palo, EF; Musile, G; Porpiglia, N; Tagliaro, F | 1 |
Barreto, AS; Brant, VF; Rodrigues, SV; Spinelli, E | 1 |
Glatz, Z; Mosher, RA; Pelcová, M; Řemínek, R; Sandbaumhüter, FA; Thormann, W | 1 |
Fassauer, GM; Hasan, M; Hofstetter, R; Link, A; Oswald, S; Siegmund, W | 1 |
Bai, YM; Chen, MH; Cheng, CM; Gueorguieva, R; Hong, CJ; Krystal, JH; Li, CT; Lin, WC; Su, TP; Tu, PC | 1 |
Barbarossa, A; Bektas, RN; Bettschart-Wolfensberger, R; Hartnack, S; Kutter, AP; Romagnoli, N; Roncada, P | 1 |
Li, SW; Lin, AY; Wang, YH | 1 |
Arıöz, F; Göktaş, EF | 1 |
Banks, A; Gao, J; Jiang, G; Lai, FY; Li, J; Mueller, JF; Thai, PK | 1 |
Boudy, V; D'Hayer, B; Fonsart, J; Houzé, P; Legagneux, J; Ramiole, C | 1 |
Fassauer, GM; Hasan, M; Hofstetter, R; Link, A; Modeß, C; Oswald, S; Siegmund, W | 1 |
Moorthy, GS; Tran, BD; Zuppa, AF | 1 |
Ichikawa, T; Mizuno-Yasuhira, A; Toki, H; Yamaguchi, JI | 1 |
Hashimoto, K; Shirayama, Y | 1 |
Downey, L; Green, M; Hayley, A; Keane, M; Kostakis, P; Shehabi, Y | 1 |
Alonzo, A; Gálvez, V; Glue, P; Huggins, C; Li, A; Loo, CK; Martin, D; Mitchell, PB; Rodgers, A; Somogyi, AA | 1 |
Sandbaumhüter, FA; Thormann, W | 1 |
Kalso, E; Kangas, E; Lilius, T; Niemi, M; Rauhala, P | 1 |
Mikkonen, S; Thormann, W | 1 |
Chaki, S; Hashimoto, K; Koike, H; Mizuno-Yasuhira, A; Qu, Y; Toki, H; Yamaguchi, JI; Yang, C | 1 |
Glue, P; Goulton, C; Le Nedelec, M; Medlicott, NJ; Winter, H | 1 |
Chaki, S; Dong, C; Han, M; Hashimoto, K; Kobayashi, S; Ma, M; Manabe, T; Nakao, K; Nakazawa, K; Qu, Y; Ren, Q; Shirayama, Y; Toki, H; Yamaguchi, JI; Yang, C; Zhang, JC | 1 |
Du, P; Li, XQ; Wang, CC; Yang, J; Zhang, HF | 1 |
Chen, L; Gong, Y; Salter, R | 1 |
Hashimoto, K; Yang, C | 1 |
Kabbaj, M; Saland, SK | 1 |
Ide, S; Ikeda, K | 1 |
Buvanendran, A; Das, V; Kroin, JS; Moric, M | 1 |
Sommerová, B; Tůma, P; Vaculín, Š | 1 |
Baumgartner, C; Fux, D; Knubben, G; Metzner, M; Rieger, A; Steckeler, P | 1 |
Adame, BC; Crawford, CA; Gomez, V; McDougall, SA; Park, GI; Ramirez, GI | 1 |
Adams, M; Downey, LA; Green, M; Hayley, AC; Keane, M; Kenneally, M; Shehabi, Y | 1 |
García-Ruiz, C; Matey, JM; Montalvo, G; Moreno de Simon, MD | 1 |
Hashimoto, K | 2 |
Burke, AK; Choo, TH; Cooper, TB; Galfalvy, HC; Grunebaum, MF; Mann, JJ; Parris, MS; Suckow, RF | 1 |
Chang, L; Fujita, A; Fujita, Y; Hashimoto, K; Pu, Y | 1 |
Hashimoto, K; Luo, A; Yang, C; Yang, J | 1 |
Hirose, H; Kaushal, G; Kraft, WK; Lam, E; Rochani, A; Tanjuakio, J | 1 |
Brandner, B; Curran, HV; Das, RK; Gale, G; Hennessy, VE; Iskandar, G; Kamboj, SK; Kindt, M; Mordecai, LA; Walsh, K | 1 |
Glatz, Z; Řemínek, R; Thormann, W | 1 |
Glue, P; Hung, CT; Hung, N; Lam, F; Medlicott, NJ; Surman, P | 1 |
Ago, Y; Chen, L; Hashimoto, H; Hashimoto, K; Higuchi, M; Kasai, A; Naito, M; Nakagawa, S; Nakazawa, T; Seiriki, K; Tanabe, W; Tsukada, S; Yamaguchi, T; Yokoyama, R | 1 |
Barter, LS; Luca, GC; Pypendop, BH | 1 |
Ahmad, SM; Neng, NR; Nogueira, JMF; Oliveira, MN | 1 |
Bickerdike, MJ; Denny, WA; Dimitrov, IV; Harvey, MG; Sleigh, JW; Voss, LJ | 1 |
Aarts, L; Dahan, A; Jonkman, K; Kamp, J; Niesters, M; Olofsen, E; van Velzen, M | 1 |
Arora, B; Ghose, S; Lalwani, S; Saxena, R; Velpandian, T | 1 |
Jang, M; Kim, J; Lee, J; Lee, S; Rhee, J; Shin, I | 1 |
Glue, P; Medlicott, NJ; Russell, B | 1 |
Carrola, JS; Gonçalves, R; M F Gonçalves, V; Pereira, JA; Pérez-Pereira, A; Pires, C; Ribeiro, C; Teles, F; Tiritan, ME | 1 |
Chen, Y; Hu, L; Wen, C; Wu, Y; Ying, L; Zhong, Z | 1 |
Bergmann, KR; Jacobs, G; Otto, ME; van Esdonk, MJ | 1 |
Chen, CK; Chen, YT; Dash, S; Hsieh, YJ; Hsu, YC; Huang, MC; Liu, JC; Wu, CC; Wu, CT; Yu, JS | 1 |
Barbarossa, A; Bardhi, A; Gazzotti, T; Pagliuca, G | 1 |
Denk, W; Katz, D; Lauritsen, C; Lovett, J; Moaddel, R; Schwenk, ES; Silberstein, SD; Torjman, MC; Wainer, IW | 1 |
Huang, C; Jiang, R; Liu, C; Wang, Y; Wu, Z; Xu, J; Yan, E; Yang, C; Yang, L; Zhou, L; Zhu, B | 1 |
Gardier, AM; McGowan, JC; Nguyen, TML | 1 |
Chen, PL; Chyueh, SC; Huang, DY; Lee, LW; Liu, YL; Tsai, YS; Tseng, SH; Yen, YT | 1 |
Andraus, M; Barroso, M; Gallardo, E; Oliveira, P; Rosado, T; Rosendo, LM; Simão, AY | 1 |
Endo, H; Mizuno-Yasuhira, A; Toki, H; Yamaguchi, JI | 1 |
Gee, P; Mackenzie, E; Schep, LJ; Slaughter, RJ; Watts, M | 1 |
Alshogran, OY; Caritis, SN; Lim, G; Pakalapati, N; Shahane, A; Shaik, IH; Venkataramanan, R; Zhao, W | 1 |
Can, AT; Dutton, M; Hermens, DF; Lagopoulos, J | 1 |
10 review(s) available for norketamine and ketamine
Article | Year |
---|---|
Pharmacokinetic and pharmacodynamic considerations for NMDA receptor antagonists in the treatment of chronic neuropathic pain.
Topics: Animals; Chronic Disease; Disease Models, Animal; Humans; Ketamine; Neuralgia; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate | 2012 |
Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy.
Topics: Analgesics; Anesthesia; Animals; Biological Availability; Central Nervous System; Child; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Administration Routes; Humans; Ketamine; Pain; Receptors, N-Methyl-D-Aspartate | 2016 |
A review of chromatographic methods for ketamine and its metabolites norketamine and dehydronorketamine.
Topics: Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2018 |
Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; History, 20th Century; History, 21st Century; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate | 2019 |
Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Hippocampus; Humans; Ketamine; Prefrontal Cortex; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stress, Psychological | 2019 |
Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine.
Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Depression; Gastrointestinal Microbiome; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Spleen | 2020 |
Influence of formulation and route of administration on ketamine's safety and tolerability: systematic review.
Topics: Antidepressive Agents; Dissociative Disorders; Drug Administration Routes; Drug Delivery Systems; Humans; Hypertension; Ketamine; Metabolic Clearance Rate | 2021 |
CYP 450 enzymes influence (R,S)-ketamine brain delivery and its antidepressant activity.
Topics: Animals; Antidepressive Agents; Cytochrome P-450 Enzyme System; Humans; Ketamine | 2022 |
The clinical toxicology of ketamine.
Topics: Analgesics; Anesthetics; Animals; Cytochrome P-450 CYP2B6; Humans; Ketamine | 2023 |
Oral ketamine may offer a solution to the ketamine conundrum.
Topics: Antidepressive Agents; Biological Availability; Humans; Ketamine; Pain | 2023 |
29 trial(s) available for norketamine and ketamine
Article | Year |
---|---|
Effects of ketamine anaesthesia on the metabolic response to pelvic surgery.
Topics: Adult; Anesthesia, Intravenous; Blood Glucose; Fallopian Tubes; Fatty Acids, Nonesterified; Female; Halothane; Hematocrit; Hemodynamics; Humans; Hydrocortisone; Intraoperative Period; Ketamine; Lactates; Lactic Acid; Pyruvates; Pyruvic Acid | 1984 |
Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children.
Topics: Administration, Intranasal; Administration, Rectal; Anesthetics, Dissociative; Child; Child, Preschool; Humans; Injections, Intravenous; Ketamine | 1996 |
S-ketamine and s-norketamine plasma concentrations after nasal and i.v. administration in anesthetized children.
Topics: Administration, Intranasal; Analgesics; Analysis of Variance; Child; Child, Preschool; Humans; Infant; Injections, Intravenous; Ketamine; Prospective Studies; Time Factors | 2004 |
Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies.
Topics: Anesthesia, General; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Blood Pressure; Cross-Over Studies; Drug Administration Schedule; Electrocardiography; Heart Rate; Horses; Isoflurane; Ketamine; Male; Monitoring, Intraoperative; Stereoisomerism | 2007 |
Development of a sublingual/oral formulation of ketamine for use in neuropathic pain: Preliminary findings from a three-way randomized, crossover study.
Topics: Administration, Oral; Administration, Sublingual; Adult; Aged; Analgesics; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Chronic Disease; Cross-Over Studies; Drug Stability; Drug Storage; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine; Male; Middle Aged; Neuralgia; Temperature | 2009 |
Use of human microsomes and deuterated substrates: an alternative approach for the identification of novel metabolites of ketamine by mass spectrometry.
Topics: Administration, Oral; Anesthetics, Dissociative; Biotransformation; Chromatography, Liquid; Consciousness; Cyclotrons; Deuterium; Female; Fourier Analysis; Glucuronides; Humans; Hydrogen-Ion Concentration; Isomerism; Ketamine; Male; Metabolomics; Microsomes, Liver; Molecular Structure; Phenols; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry | 2009 |
Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain.
Topics: Administration, Intranasal; Adult; Aged; Algorithms; Anesthetics, Dissociative; Cardiovascular System; Female; Hemodynamics; Humans; Ketamine; Male; Middle Aged; Pain; Pain Measurement; Peripheral Nervous System Diseases; Stereoisomerism | 2010 |
Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect.
Topics: Adult; Affect; Anesthetics, Dissociative; Biomarkers; Cross-Over Studies; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Ketamine; Male; Predictive Value of Tests; Prefrontal Cortex; Theta Rhythm | 2010 |
Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Infusions, Intravenous; Ketamine; Male; Rifampin; Single-Blind Method | 2011 |
St John's wort greatly decreases the plasma concentrations of oral S-ketamine.
Topics: Adult; Analgesics; Antidepressive Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Humans; Hypericum; Ketamine; Male; Neuropsychological Tests; Plant Preparations; Psychomotor Performance; Regression Analysis; Young Adult | 2012 |
Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine.
Topics: Administration, Oral; Adult; Anesthetics, Dissociative; Antifungal Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Double-Blind Method; Drug Interactions; Female; Humans; Itraconazole; Ketamine; Male; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2011 |
S-ketamine concentrations are greatly increased by grapefruit juice.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Beverages; Citrus paradisi; Cross-Over Studies; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Female; Food-Drug Interactions; Humans; Ketamine; Male; Middle Aged; Oxidoreductases, N-Demethylating; Young Adult | 2012 |
Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression.
Topics: Adult; Algorithms; Antidepressive Agents; Biotransformation; Bipolar Disorder; Cross-Over Studies; Double-Blind Method; Drug Resistance; Female; Humans; Hydroxylation; Infusions, Parenteral; Ketamine; Male; Middle Aged; Models, Biological; Young Adult | 2012 |
Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Depression; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged; Outcome Assessment, Health Care; Psychiatric Status Rating Scales; Riluzole; Time Factors; Young Adult | 2012 |
Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Brain Mapping; Cerebral Cortex; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Electric Stimulation; Female; Fingers; Functional Laterality; Humans; Ketamine; Magnetoencephalography; Male; Middle Aged; Psychiatric Status Rating Scales; Reaction Time; Synaptic Potentials; Time Factors; Treatment Outcome | 2012 |
Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine.
Topics: Administration, Oral; Analgesics; Biological Availability; Biotransformation; Cross-Over Studies; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Half-Life; Humans; Injections, Intravenous; Ketamine; Male; Metabolic Clearance Rate; Psychomotor Performance; Rifampin; Sleep Stages | 2012 |
Estimation of the contribution of norketamine to ketamine-induced acute pain relief and neurocognitive impairment in healthy volunteers.
Topics: Acute Pain; Adolescent; Adult; Analgesics; Cognition; Hot Temperature; Humans; Ketamine; Male; Memory; Pain Management; Pain Measurement; Psychomotor Performance; Reaction Time; Reference Values; Single-Blind Method; Young Adult | 2012 |
Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report.
Topics: Administration, Intranasal; Anesthetics, Dissociative; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Infant; Ketamine; Lacerations; Prospective Studies | 2012 |
Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteers.
Topics: Adult; Anesthetics, Dissociative; Brain; Data Interpretation, Statistical; Hallucinogens; Hot Temperature; Humans; Image Processing, Computer-Assisted; Injections, Intravenous; Ketamine; Linear Models; Magnetic Resonance Imaging; Male; Nerve Net; Pain; Pain Measurement; Single-Blind Method; Young Adult | 2012 |
A randomized controlled trial of intranasal ketamine in major depressive disorder.
Topics: Administration, Intranasal; Adult; Aged; Antidepressive Agents; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Female; Follow-Up Studies; Humans; Ketamine; Male; Middle Aged; Psychiatric Status Rating Scales; Time Factors; Treatment Outcome; Young Adult | 2014 |
Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression.
Topics: Adult; Antidepressive Agents; Asian People; Blood Pressure; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Ketamine; Male; Middle Aged; Polymorphism, Genetic; Psychiatric Status Rating Scales; Taiwan; Treatment Outcome | 2017 |
Pharmacokinetics of ketamine and norketamine enantiomers after racemic or S-ketamine IV bolus administration in dogs during sevoflurane anaesthesia.
Topics: Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Chromatography, Liquid; Cross-Over Studies; Dogs; Infusions, Intravenous; Injections, Intravenous; Ketamine; Male; Methyl Ethers; Sevoflurane | 2017 |
Repeated intranasal ketamine for treatment-resistant depression - the way to go? Results from a pilot randomised controlled trial.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Analgesics; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Female; Humans; Ketamine; Male; Midazolam; Middle Aged; Pilot Projects; Treatment Outcome | 2018 |
The course of plasma cortisol concentration after three different doses of ketamine in xylazine-premedicated calves.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Cattle; Dose-Response Relationship, Drug; Female; Hydrocortisone; Ketamine; Male; Pain Measurement; Premedication; Prospective Studies; Random Allocation; Single-Blind Method; Xylazine | 2019 |
Neurocognitive performance under combined regimens of ketamine-dexmedetomidine and ketamine-fentanyl in healthy adults: A randomised trial.
Topics: Adult; Choice Behavior; Dexmedetomidine; Drug Synergism; Female; Fentanyl; Humans; Ketamine; Male; Memory, Short-Term; Reaction Time; Recognition, Psychology; Young Adult | 2019 |
Ketamine metabolite pilot study in a suicidal depression trial.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Humans; Infusions, Parenteral; Ketamine; Midazolam; Outcome Assessment, Health Care; Pilot Projects; Severity of Illness Index; Suicidal Ideation | 2019 |
Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories.
Topics: Adaptation, Psychological; Adult; Alcohol Drinking; Biomarkers; Female; Humans; Ketamine; Male; Memory; Reinforcement, Psychology; Treatment Outcome | 2019 |
Ascending-Dose Study of Controlled-Release Ketamine Tablets in Healthy Volunteers: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability.
Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Antidepressive Agents; Area Under Curve; Blood Pressure; Brain-Derived Neurotrophic Factor; Delayed-Action Preparations; Dissociative Disorders; Double-Blind Method; Drug Administration Schedule; Female; Healthy Volunteers; Humans; Ketamine; Male; Middle Aged; Tablets; Time Factors; Young Adult | 2020 |
Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis.
Topics: Adult; Anesthetics, Dissociative; Biotransformation; Computer Simulation; Cross-Over Studies; Double-Blind Method; Drug Compounding; Female; Humans; Injections, Intravenous; Ketamine; Male; Models, Theoretical; Nitroprusside; Postoperative Complications; Stereoisomerism; Young Adult | 2020 |
165 other study(ies) available for norketamine and ketamine
Article | Year |
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Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.
Topics: Anesthesia; Animals; Brain; Ketamine; Male; Rats; Rats, Inbred Strains | 1986 |
Highly predictive and interpretable models for PAMPA permeability.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine | 2017 |
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility | 2019 |
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States | 2020 |
Metabolism of ketamine stereoisomers by human liver microsomes.
Topics: Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Ketamine; Microsomes, Liver; Stereoisomerism | 1992 |
Stereoselective high-performance liquid chromatographic determination of the enantiomers of ketamine and norketamine in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Ketamine | 1991 |
Pharmacokinetics and distribution of ketamine after extradural administration to dogs.
Topics: Anesthesia, Epidural; Anesthesia, General; Animals; Biotransformation; Brain; Dogs; Female; Half-Life; Ketamine; Male | 1991 |
Enantioselective N-demethylation of ketamine in the horse.
Topics: Animals; Chromatography; Horses; Injections, Intravenous; Ketamine; Male; Molecular Conformation | 1991 |
Correlation between drug and metabolite concentrations in plasma and anesthetic action of ketamine in swine.
Topics: Anesthesia; Animals; Female; Injections, Intramuscular; Injections, Intravenous; Ketamine; Male; Swine; Time Factors | 1990 |
Pharmacokinetics of rectal ketamine in children.
Topics: Administration, Rectal; Child; Half-Life; Humans; Ketamine | 1989 |
Studies on the biotransformation of ketamine. II--Quantitative significance of the N-demethylation pathway in rats in vivo determined by a novel stable isotope technique.
Topics: Animals; Biotransformation; Dealkylation; Deuterium; Ketamine; Male; Rats; Rats, Inbred Strains | 1989 |
Pharmacokinetic and clinical evaluation of ketamine administered by i.v. and epidural routes.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Half-Life; Humans; Injections, Epidural; Injections, Intravenous; Ketamine; Kinetics; Middle Aged; Respiration | 1987 |
Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations.
Topics: Animals; Biotransformation; Chromatography, Gas; Humans; In Vitro Techniques; Ketamine; Male; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Spectrum Analysis; Stereoisomerism | 1987 |
Quantitative deconvolution of heavily fused chromatographic peaks of biological components using a multi-wavelength UV detector.
Topics: Animals; Chemical Phenomena; Chemistry; Ketamine; Rabbits; Spectrophotometry, Ultraviolet | 1985 |
Ketamine disposition in children and adults.
Topics: Adult; Aged; Anesthesia, General; Child; Child, Preschool; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Ketamine; Kinetics; Male; Middle Aged; Time Factors | 1983 |
Influence of premedication with xylazine on the distribution and metabolism of intramuscularly administered ketamine in cats.
Topics: Animals; Cats; Female; Injections, Intramuscular; Ketamine; Kinetics; Male; Preanesthetic Medication; Thiazines; Tissue Distribution; Xylazine | 1983 |
Gas chromatographic analysis of ketamine and norketamine in plasma and urine: nitrogen-sensitive detection.
Topics: Adult; Animals; Child; Chromatography, Gas; Dogs; Haplorhini; Humans; Ketamine; Kinetics; Nitrogen | 1982 |
Rectal ketamine for induction of anaesthesia in children.
Topics: Anesthesia, Rectal; Atropine; Child; Diazepam; Female; Half-Life; Humans; Ketamine; Kinetics; Male; Preanesthetic Medication | 1983 |
Stereochemical studies of demethylated ketamine enantiomers.
Topics: Anesthetics; Animals; Ketamine; Male; Mice; Molecular Conformation; Stereoisomerism | 1982 |
Studies on the biotransformation of ketamine. 1-Identification of metabolites produced in vitro from rat liver microsomal preparations.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Ketamine; Male; Microsomes, Liver; Rats; Rats, Inbred Strains | 1981 |
Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia.
Topics: Aged; Female; Herpesviridae Infections; Humans; Infusion Pumps, Implantable; Ketamine; Male; Neuralgia; Prospective Studies; Receptors, N-Methyl-D-Aspartate | 1995 |
Response of chronic neuropathic pain syndromes to ketamine: a role for norketamine?
Topics: Humans; Ketamine; Pain; Pain, Intractable | 1995 |
Low-dose midazolam antagonizes cerebral metabolic stimulation by ketamine in the pig.
Topics: Acid-Base Equilibrium; Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Electroencephalography; Hydrogen-Ion Concentration; Ketamine; Midazolam; Oxygen Consumption; Swine; Vascular Resistance | 1993 |
Cerebral pharmacodynamics of anaesthetic and subanaesthetic doses of ketamine in the normoventilated pig.
Topics: Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Electroencephalography; Hydrogen-Ion Concentration; Infusions, Intravenous; Ketamine; Oxygen; Oxygen Consumption; Respiration; Swine; Time Factors; Vascular Resistance | 1993 |
Postoperative analgesia and sedation following pediatric cardiac surgery using a constant infusion of ketamine.
Topics: Analgesia; Cardiac Surgical Procedures; Child, Preschool; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Infusions, Intravenous; Intensive Care Units, Pediatric; Intubation, Intratracheal; Ketamine; Midazolam; Postoperative Care; Postoperative Period; Respiration, Artificial; Ventilator Weaning | 1993 |
Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine: a pharmacokinetic study.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; Horses; Imidazoles; Infusions, Intravenous; Ketamine; Metabolic Clearance Rate; Premedication; Propofol | 1996 |
Determination of ketamine and norketamine enantiomers in plasma by solid-phase extraction and high-performance liquid chromatography.
Topics: Anesthetics, Dissociative; Chromatography, High Pressure Liquid; Humans; Ketamine; Methanol; Microchemistry; Stereoisomerism | 1996 |
Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord.
Topics: Animals; Animals, Newborn; Binding, Competitive; Cerebral Cortex; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ketamine; Phencyclidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stereoisomerism | 1997 |
HPLC determination of ketamine, norketamine, and dehydronorketamine in plasma with a high-purity reversed-phase sorbent.
Topics: Acetates; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Ketamine; Methylene Chloride; Sensitivity and Specificity; Tilidine | 1998 |
Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine.
Topics: Administration, Oral; Animals; Behavior, Animal; Binding, Competitive; Central Nervous System; Formaldehyde; Injections, Spinal; Ketamine; Male; Nociceptors; Osmolar Concentration; Pain; Rats; Rats, Sprague-Dawley | 1999 |
Stereoselective high-performance liquid chromatographic determination of ketamine and its active metabolite, norketamine, in human plasma.
Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Humans; Ketamine; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2000 |
Stability of ketamine and its metabolites norketamine and dehydronorketamine in human biological samples.
Topics: Blood Specimen Collection; Chromatography, High Pressure Liquid; Humans; Ketamine; Temperature; Time Factors | 2001 |
Tissue uptake of ketamine and norketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion.
Topics: Animals; Area Under Curve; Ketamine; Liver; Male; Rats; Rats, Wistar; Stereoisomerism; Tissue Distribution | 2001 |
Urine concentrations of ketamine and norketamine following illegal consumption.
Topics: Anesthetics, Dissociative; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Mass Spectrometry; Reference Values; Sensitivity and Specificity; Substance Abuse Detection | 2001 |
Protein binding of ketamine and its active metabolites to human serum.
Topics: Anesthetics, Dissociative; Blood Proteins; Humans; Ketamine; Protein Binding; Ultrafiltration | 2002 |
Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers.
Topics: Administration, Intranasal; Adult; Analysis of Variance; Area Under Curve; Chemistry, Pharmaceutical; Humans; Ketamine; Male; Stereoisomerism; Vaginal Creams, Foams, and Jellies | 2003 |
Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury.
Topics: Adult; Analysis of Variance; Anesthetics, Dissociative; Blood Pressure; Brain Injuries; Critical Care; Female; Half-Life; Heart Rate; Hemodynamics; Humans; Ketamine; Male; Metabolic Clearance Rate; Middle Aged; Spinal Cord Injuries | 2003 |
Determination of the enantiomers of ketamine and norketamine in human plasma by enantioselective liquid chromatography-mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Humans; Ketamine; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2003 |
Gas chromatography-isotope dilution mass spectrometry preceded by liquid-liquid extraction and chemical derivatization for the determination of ketamine and norketamine in urine.
Topics: Anesthetics, Dissociative; Gas Chromatography-Mass Spectrometry; Ketamine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Detection of acid-labile conjugates of ketamine and its metabolites in urine samples collected from pub participants.
Topics: Dancing; Gas Chromatography-Mass Spectrometry; Humans; Hydrochloric Acid; Hydrolysis; Illicit Drugs; Ketamine; Reproducibility of Results; Taiwan | 2004 |
Use of SPE and LC/TIS/MS/MS for rapid detection and quantitation of ketamine and its metabolite, norketamine, in urine.
Topics: Anesthetics, Dissociative; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Molecular Structure; Substance Abuse Detection | 2005 |
Detection of ketamine and norketamine in urine of nonhuman primates after a single dose of ketamine using microplate enzyme-linked immunosorbent assay (ELISA) and NCI-GC-MS.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Injections, Intramuscular; Ketamine; Macaca; Male; Models, Animal; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection; Time Factors | 2005 |
Quantitative detection of ketamine, norketamine, and dehydronorketamine in urine using chemical derivatization followed by gas chromatography-mass spectrometry.
Topics: Anesthetics, Dissociative; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Characterization of the stereoselective biotransformation of ketamine to norketamine via determination of their enantiomers in equine plasma by capillary electrophoresis.
Topics: Anesthetics; Animals; Biotransformation; Calibration; Drug Interactions; Horses; Ketamine; Reproducibility of Results; Stereoisomerism | 2005 |
Pharmacokinetics of ketamine and its metabolite, norketamine, after intravenous administration of a bolus of ketamine to isoflurane-anesthetized dogs.
Topics: Anesthetics, Inhalation; Animals; Chromatography, Liquid; Dogs; Injections, Intravenous; Isoflurane; Ketamine; Mass Spectrometry; Models, Biological | 2005 |
Cardiovascular and respiratory effects of ketamine infusions in isoflurane-anesthetized dogs before and during noxious stimulation.
Topics: Anesthesia, Inhalation; Animals; Cardiovascular System; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Hydrogen-Ion Concentration; Injections, Intravenous; Isoflurane; Ketamine; Oxygen; Oxygen Consumption | 2005 |
On-line preconcentration and determination of ketamine and norketamine by micellar electrokinetic chromatography. Complementary method to gas chromatography/mass spectrometry.
Topics: Chromatography, Micellar Electrokinetic Capillary; Gas Chromatography-Mass Spectrometry; Ketamine; Reproducibility of Results; Sensitivity and Specificity | 2006 |
The effect of ketamine on intraspinal acetylcholine release: involvement of spinal nicotinic receptors.
Topics: Acetylcholine; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Bridged Bicyclo Compounds, Heterocyclic; Isoflurane; Ketamine; Male; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Time Factors | 2006 |
Hair analysis for ketamine and its metabolites.
Topics: Anesthetics, Dissociative; Chromatography, Gas; Dose-Response Relationship, Drug; Forensic Medicine; Hair; Hair Color; Humans; Ketamine; Male; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2006 |
Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion.
Topics: Algorithms; Analgesics; Anesthesia; Anesthetics, Dissociative; Animals; Biotransformation; Drug Delivery Systems; Electrophysiology; Horses; Infusions, Intravenous; Ketamine; Male; Models, Statistical; Pain Measurement; Reflex; Stereoisomerism; Tissue Distribution | 2006 |
Determination of ketamine and norketamine in hair by gas chromatography/mass spectrometry using two-step derivatization.
Topics: Gas Chromatography-Mass Spectrometry; Hair; Illicit Drugs; Ketamine; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection | 2006 |
Performance characteristics of ELISAs for monitoring ketamine exposure.
Topics: Anesthetics, Dissociative; Calibration; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Sensitivity and Specificity; Substance Abuse Detection | 2007 |
GC-MS quantification of ketamine, norketamine, and dehydronorketamine in urine specimens and comparative study using ELISA as the preliminary test methodology.
Topics: Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Sensitivity and Specificity | 2007 |
Analysis of ketamine and norketamine in urine by automatic solid-phase extraction (SPE) and positive ion chemical ionization-gas chromatography-mass spectrometry (PCI-GC-MS).
Topics: Animals; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Ketamine; Male; Rats; Rats, Sprague-Dawley; Substance Abuse Detection | 2008 |
Enantioselective analysis of ketamine and its metabolites in equine plasma and urine by CE with multiple isomer sulfated beta-CD.
Topics: Animals; beta-Cyclodextrins; Electrophoresis, Capillary; Horses; Ketamine; Stereoisomerism; Sulfates | 2007 |
Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration in Shetland ponies sedated with xylazine.
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Blood Gas Analysis; Cross-Over Studies; Horses; Ketamine; Male; Random Allocation; Stereoisomerism; Xylazine | 2008 |
Ketamine levels in plasma and red blood cells after intravenous administration in the horse.
Topics: Animals; Erythrocytes; Horses; Injections, Intravenous; Ketamine; Plasma | 2007 |
Modeling the norketamine metabolite in children and the implications for analgesia.
Topics: Adult; Aged; Analgesia; Analysis of Variance; Anesthetics, Dissociative; Child; Child, Preschool; Chromatography, High Pressure Liquid; Conscious Sedation; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Ketamine; Male; Mass Spectrometry; Middle Aged; Models, Statistical; Population; Reference Standards; Reproducibility of Results; Solid Phase Extraction | 2007 |
Simultaneous determination of ketamine, tramadol, methadone, and their metabolites in urine by gas chromatography-mass spectrometry.
Topics: Analgesics; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Methadone; Narcotics; Pyrrolidines; Tramadol | 2008 |
[Determination of ketamine and norketamine in blood and urine by high performance liquid chromatography].
Topics: Animals; Chromatography, High Pressure Liquid; Female; Ketamine; Male; Rats; Rats, Wistar | 2008 |
Interaction between morphine and norketamine enantiomers in rodent models of nociception.
Topics: Analgesics, Opioid; Animals; Constriction, Pathologic; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Formaldehyde; Ketamine; Male; Morphine; Motor Activity; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Stereoisomerism | 2008 |
Effects of norketamine enantiomers in rodent models of persistent pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Formaldehyde; Hot Temperature; Hyperalgesia; Ketamine; Male; Motor Activity; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Stereotyped Behavior | 2008 |
Plasma levels of a low-dose constant-rate-infusion of ketamine and its effect on single and repeated nociceptive stimuli in conscious dogs.
Topics: Anesthetics, Dissociative; Animals; Dogs; Dose-Response Relationship, Drug; Electromyography; Infusions, Intravenous; Ketamine; Male; Nociceptors; Pain; Prospective Studies; Stereoisomerism; Transcutaneous Electric Nerve Stimulation | 2009 |
Utility of immunoassay in drug screening in skeletal tissues: sampling considerations in detection of ketamine exposure in femoral bone and bone marrow following acute administration using ELISA.
Topics: Analgesics; Animals; Bone Marrow; Chromatography, Gas; Diaphyses; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epiphyses; Femur; Forensic Toxicology; Hydrogen-Ion Concentration; Ketamine; Male; Rats; Rats, Wistar; Substance Abuse Detection | 2008 |
Detection of ketamine and its metabolites in urine by ultra high pressure liquid chromatography-tandem mass spectrometry.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Ketamine; Male; Tandem Mass Spectrometry | 2008 |
Stereoselective biotransformation of ketamine in equine liver and lung microsomes.
Topics: Analgesics; Animals; Biotransformation; Female; Horses; In Vitro Techniques; Ketamine; Lung; Male; Metabolic Clearance Rate; Microsomes, Liver; Models, Biological; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Substrate Specificity | 2008 |
Pharmacokinetics of ketamine and its metabolite norketamine administered at a sub-anesthetic dose together with xylazine to calves prior to castration.
Topics: Adrenergic alpha-Agonists; Anesthesia, Intravenous; Anesthetics, Dissociative; Animals; Cattle; Chromatography, Liquid; Drug Combinations; Ketamine; Male; Orchiectomy; Pain; Xylazine | 2009 |
Rapid detection of ketamine and norketamine in rat hair using micropulverized extraction and ultra-performance liquid chromatography-electrospray ionization mass spectrometry.
Topics: Anesthetics, Dissociative; Animals; Chromatography, Liquid; Hair; Ketamine; Rats; Spectrometry, Mass, Electrospray Ionization | 2009 |
Stereoselective pharmacokinetics of ketamine and norketamine after constant rate infusion of a subanesthetic dose of racemic ketamine or S-ketamine in Shetland ponies.
Topics: Animals; Area Under Curve; Half-Life; Horses; Ketamine; Male | 2009 |
Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier.
Topics: Animals; Cells, Cultured; Cytoskeleton; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Exocytosis; Female; Glomerular Filtration Rate; Glutamic Acid; Ketamine; Kidney Diseases; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Podocytes; rab3A GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2009 |
CE provides evidence of the stereoselective hydroxylation of norketamine in equines.
Topics: Animals; Chromatography, Liquid; Electrophoresis, Capillary; Horses; Hydroxylation; Ketamine; Mass Spectrometry; Microsomes, Liver; Stereoisomerism | 2009 |
S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.
Topics: Adolescent; Adult; Algorithms; Anesthetics, Dissociative; Cardiac Output; Dose-Response Relationship, Drug; Electric Stimulation; Endpoint Determination; Female; Hot Temperature; Humans; Hyperalgesia; Infusions, Intravenous; Ketamine; Male; Models, Statistical; Pain; Pain Measurement; Pain Threshold; Sex Characteristics; Young Adult | 2009 |
Determination of amphetamine-type stimulants, ketamine and metabolites in fingernails by gas chromatography-mass spectrometry.
Topics: Amphetamines; Analgesics; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Nails; Substance Abuse Detection | 2010 |
Rapid and simple determination of psychotropic phenylalkylamine derivatives in human hair by gas chromatography-mass spectrometry using micro-pulverized extraction.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Hallucinogens; Humans; Ketamine; Limit of Detection; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Substance Abuse Detection | 2010 |
Identification and quantitation of ketamine in biological matrices using gas chromatography-mass spectrometry (GC-MS).
Topics: Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Reproducibility of Results; Solid Phase Extraction | 2010 |
Analysis of ketamine and norketamine in hair samples using molecularly imprinted solid-phase extraction (MISPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Topics: Chromatography, High Pressure Liquid; Hair; Humans; Illicit Drugs; Ketamine; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2010 |
A fast screening procedure for ketamine and metabolites in urine samples with tandem mass spectrometry.
Topics: Calibration; Enzyme-Linked Immunosorbent Assay; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry | 2010 |
Alveolar but not intravenous S-ketamine inhibits alveolar sodium transport and lung fluid clearance in rats.
Topics: Anesthetics, Dissociative; Animals; Atmosphere Exposure Chambers; Body Fluids; Bronchoalveolar Lavage Fluid; Cell Separation; Cells, Cultured; Endotoxemia; Injections, Intravenous; Ketamine; Lipopolysaccharides; Lung; Male; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium Channels | 2010 |
Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro.
Topics: Analgesics; Biotransformation; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Humans; Hydroxylation; Ketamine; Kinetics; Microsomes, Liver; Stereoisomerism | 2010 |
Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome.
Topics: Adolescent; Adult; Analgesics; Chromatography, Liquid; Complex Regional Pain Syndromes; Female; Humans; Infusions, Intravenous; Ketamine; Male; Mass Spectrometry; Middle Aged; Stereoisomerism; Structure-Activity Relationship; Time Factors; Treatment Outcome; Young Adult | 2011 |
Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs.
Topics: Animals; Anions; Antifungal Agents; beta-Cyclodextrins; Drug Design; Electrophoresis; Electrophoresis, Capillary; Ketamine; Male; Microsomes, Liver; Models, Chemical; Rats; Stereoisomerism; Time Factors | 2011 |
The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS.
Topics: Excitatory Amino Acid Antagonists; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Ketamine; Limit of Detection; Molecular Structure; Specimen Handling; Substance Abuse Detection | 2011 |
Disposition of ketamine and norketamine in hair after a single dose.
Topics: Administration, Oral; Adult; Anesthetics, Dissociative; Chromatography, Liquid; Female; Forensic Medicine; Hair; Humans; Ketamine; Tandem Mass Spectrometry | 2011 |
[Toxicokinetics of ketamine in rabbits].
Topics: Administration, Oral; Anesthetics, Dissociative; Animals; Blood Pressure; Gas Chromatography-Mass Spectrometry; Heart Rate; Ketamine; Male; Perceptual Disorders; Rabbits; Random Allocation; Time Factors | 2010 |
Determination of amphetamine-type stimulants, cocaine and ketamine in human hair by liquid chromatography/linear ion trap-Orbitrap hybrid mass spectrometry.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Chromatography, Liquid; Cocaine; Hair; Humans; Illicit Drugs; Ketamine; Limit of Detection; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Tandem Mass Spectrometry | 2011 |
Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures.
Topics: Administration, Oral; Anesthetics, Dissociative; Biological Availability; Biotransformation; Burns; Child; Child, Preschool; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Infusions, Intravenous; Injections, Intravenous; Ketamine; Male; Pain | 2011 |
Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.
Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Cold Temperature; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Foot Injuries; Hyperalgesia; Infrared Rays; Ketamine; Motor Activity; Neuralgia; Pain; Pain Measurement; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 2011 |
Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d₄.
Topics: Chlorobenzenes; Deuterium; Drug Design; Drug Discovery; Halogenation; Ketamine | 2011 |
Relative distribution of ketamine and norketamine in skeletal tissues following various periods of decomposition.
Topics: Animals; Bone and Bones; Calibration; Data Interpretation, Statistical; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Ketamine; Linear Models; Male; Postmortem Changes; Rats; Rats, Wistar; Reproducibility of Results; Solid Phase Extraction; Substance Abuse Detection; Time Factors; Tissue Distribution | 2011 |
Rapid and simple GC-MS method for determination of psychotropic phenylalkylamine derivatives in nails using micro-pulverized extraction.
Topics: Amphetamines; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Limit of Detection; Linear Models; Nails; Substance Abuse Detection | 2012 |
Enantioselective capillary electrophoresis for the assessment of CYP3A4-mediated ketamine demethylation and inhibition in vitro.
Topics: beta-Cyclodextrins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Electrophoresis, Capillary; gamma-Cyclodextrins; Humans; Ketamine; Ketoconazole; Kinetics; Methylation; Nonlinear Dynamics; Recombinant Proteins; Stereoisomerism | 2011 |
Cell signaling analysis by mass spectrometry under coculture conditions on an integrated microfluidic device.
Topics: Animals; Coculture Techniques; Dimethylpolysiloxanes; Dopamine; Growth Hormone; Ketamine; Microfluidic Analytical Techniques; PC12 Cells; Rats; Signal Transduction; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization | 2011 |
Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans.
Topics: Analgesics; Anesthetics, Dissociative; Animals; Antibodies, Blocking; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Electrophoresis, Capillary; Enzyme Inhibitors; Female; Horses; Humans; Ketamine; Male; Methylation; Microsomes, Liver; Species Specificity; Stereoisomerism | 2011 |
The first international proficiency test on ketamine and norketamine in hair.
Topics: Anesthetics, Dissociative; Chromatography, Liquid; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Internationality; Ketamine; Laboratories | 2012 |
Comparison of relative distribution of ketamine and norketamine in decomposed skeletal tissues following single and repeated exposures.
Topics: Algorithms; Anesthetics, General; Animals; Biotransformation; Bone and Bones; Dose-Response Relationship, Drug; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Injections, Intraperitoneal; Ketamine; Male; Organ Specificity; Postmortem Changes; Rats; Rats, Wistar; Solid Phase Extraction; Tissue Distribution | 2012 |
Stereoselective and regiospecific hydroxylation of ketamine and norketamine.
Topics: Anesthetics, Dissociative; Complex Regional Pain Syndromes; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Ketamine | 2012 |
Estimation of the measurement uncertainty in quantitative determination of ketamine and norketamine in urine using a one-point calibration method.
Topics: Calibration; Chromatography, Gas; Humans; Ketamine; Substance Abuse Detection; Uncertainty | 2012 |
Electrophoretically mediated microanalysis for characterization of the enantioselective CYP3A4 catalyzed N-demethylation of ketamine.
Topics: Cytochrome P-450 CYP3A; Electrophoresis, Capillary; Equipment Design; Humans; Ketamine; Kinetics; Methylation; NADP; Nonlinear Dynamics; Stereoisomerism | 2012 |
Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit.
Topics: Adjuvants, Immunologic; Animals; Biophysics; Calcium; Cell Differentiation; Cell Line; Diterpenes; Electric Stimulation; Electroporation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ketamine; Large-Conductance Calcium-Activated Potassium Channels; Lithium Chloride; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Time Factors; Transfection | 2012 |
Determination of ketamine and norketamine in hair by micropulverized extraction and liquid chromatography-high resolution mass spectrometry.
Topics: Adolescent; Adult; Anesthetics, Dissociative; Chromatography, Liquid; Female; Forensic Toxicology; Hair; Humans; Ketamine; Limit of Detection; Male; Mass Spectrometry; Substance Abuse Detection; Substance-Related Disorders | 2013 |
Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry.
Topics: Humans; Illicit Drugs; Ketamine; Saliva; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Substance-Related Disorders | 2013 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined Modality Therapy; Consciousness Disorders; Cyclohexanecarboxylic Acids; Diaper Rash; Drug Combinations; Drug Compounding; Drug Overdose; Emergencies; Gabapentin; gamma-Aminobutyric Acid; Humans; Imipramine; Infant; Intensive Care Units, Pediatric; Intubation, Intratracheal; Ketamine; Lidocaine; Male; Mefenamic Acid; Ointments; Reflex, Abnormal; Respiration Disorders; Skin Absorption | 2013 |
Estimating daily and diurnal variations of illicit drug use in Hong Kong: a pilot study of using wastewater analysis in an Asian metropolitan city.
Topics: Chromatography, Liquid; Cocaine; Hong Kong; Humans; Ketamine; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Pilot Projects; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry; Time Factors; Urban Population; Wastewater | 2013 |
Ketamine and the metabolite norketamine: persistence and phototransformation toxicity in hospital wastewater and surface water.
Topics: Aliivibrio fischeri; Chromatography, Liquid; Environmental Monitoring; Fresh Water; Hospitals; Ketamine; Lethal Dose 50; Photolysis; Taiwan; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2014 |
Development of a method for analysis of ketamine and norketamine enantiomers in equine brain and cerebrospinal fluid by capillary electrophoresis.
Topics: Animals; Brain Chemistry; Electrophoresis, Capillary; Horses; Ketamine; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2014 |
Determination of ketamine, norketamine and dehydronorketamine in urine by hollow-fiber liquid-phase microextraction using an essential oil as supported liquid membrane.
Topics: Anesthetics, Dissociative; Eucalyptus; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydrochloric Acid; Ketamine; Limit of Detection; Liquid Phase Microextraction; Plant Oils | 2014 |
Ketamine metabolomics in the treatment of major depression.
Topics: Animals; Excitatory Amino Acid Antagonists; Ketamine; Male; TOR Serine-Threonine Kinases | 2014 |
(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.
Topics: Aconitine; Animals; Blotting, Western; Brain; Excitatory Amino Acid Antagonists; Ketamine; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Phosphorylation; Prefrontal Cortex; Rats; Rats, Wistar; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Enhancing ketamine translational pharmacology via receptor occupancy normalization.
Topics: Animals; Depression; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ketamine; Macaca fascicularis; Male; Memory; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Species Specificity; Tritium | 2014 |
The influence of body position and microclimate on ketamine and metabolite distribution in decomposed skeletal remains.
Topics: Animals; Bone and Bones; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Ketamine; Male; Microclimate; Postmortem Changes; Posture; Rats; Rats, Wistar; Reproducibility of Results; Solid Phase Extraction | 2014 |
Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Drug Tolerance; Injections, Subcutaneous; Ketamine; Liver; Morphine; Morphine Derivatives; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2015 |
What is hydroxynorketamine and what can it bring to neurotherapeutics?
Topics: Animals; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Humans; Ketamine; Rats | 2014 |
Cut-off proposal for the detection of ketamine in hair.
Topics: Adolescent; Adult; Anesthetics, Dissociative; Chromatography, High Pressure Liquid; Female; Forensic Toxicology; Hair; Humans; Ketamine; Male; Mass Spectrometry; Substance Abuse Detection; Substance-Related Disorders; Young Adult | 2015 |
Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing.
Topics: Administration, Oral; Adult; Analgesics; Chronic Pain; Healthy Volunteers; Humans; Infusions, Intravenous; Ketamine; Young Adult | 2015 |
Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs.
Topics: Animals; Drug Discovery; Female; Hypnotics and Sedatives; Ketamine; Male; Rabbits; Rats; Rats, Sprague-Dawley; Reflex, Righting | 2015 |
Antidepressant-like effects of ketamine, norketamine and dehydronorketamine in forced swim test: Role of activity at NMDA receptor.
Topics: Administration, Oral; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketamine; Male; Mice; Motor Activity; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Swimming; Tritium | 2015 |
Determination of ketamine and its major metabolite, norketamine, in urine and plasma samples using microextraction by packed sorbent and gas chromatography-tandem mass spectrometry.
Topics: Calibration; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Limit of Detection; Reference Standards; Tandem Mass Spectrometry | 2015 |
Physiological and pharmacokinetic effects of multilevel caging on Sprague Dawley rats under ketamine-xylazine anesthesia.
Topics: Anesthetics, Dissociative; Animals; Half-Life; Housing, Animal; Hypnotics and Sedatives; Ketamine; Male; Rats; Rats, Sprague-Dawley; Reflex; Specific Pathogen-Free Organisms; Xylazine | 2016 |
Chiral separation and determination of ketamine and norketamine in hair by capillary electrophoresis.
Topics: Electrophoresis, Capillary; Forensic Sciences; Hair; Humans; Ketamine; Liquid-Liquid Extraction; Stereoisomerism | 2016 |
Validation of a SPE-LC-MS/MS method for the determination of ketamine and norketamine in micropulverized hair after a single IV dose.
Topics: Adult; Aged; Calibration; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Hair; Humans; Injections, Intravenous; Ketamine; Limit of Detection; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2016 |
Simulation and experimental study of enzyme and reactant mixing in capillary electrophoresis based on-line methods.
Topics: Buffers; Computer Simulation; Cytochrome P-450 CYP3A; Diffusion; Electrophoresis, Capillary; Enzyme Assays; Hydrodynamics; Ketamine | 2016 |
Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples.
Topics: Adult; Chromatography, Liquid; Feces; Humans; Ketamine; Male; Pilot Projects; Stereoisomerism; Tandem Mass Spectrometry | 2017 |
Ecotoxicological effect of ketamine: Evidence of acute, chronic and photolysis toxicity to Daphnia magna.
Topics: Animals; Daphnia; Ketamine; Lethal Dose 50; Photolysis; Reproduction; Toxicity Tests, Acute; Toxicity Tests, Chronic; Water Pollutants, Chemical | 2017 |
Evaluation of in-sewer transformation of selected illicit drugs and pharmaceutical biomarkers.
Topics: Biofilms; Biomarkers; Carbamazepine; Codeine; Environmental Monitoring; Illicit Drugs; Ketamine; Methamphetamine; Sewage; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2017 |
Determination of ketamine and its main metabolites by liquid chromatography coupled to tandem mass spectrometry in pig plasma: Comparison of extraction methods.
Topics: Animals; Chromatography, Liquid; Ketamine; Liquid-Liquid Extraction; Plasma; Reproducibility of Results; Solid Phase Extraction; Swine; Tandem Mass Spectrometry | 2017 |
Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection.
Topics: Antidepressive Agents; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Depressive Disorder, Major; Humans; Hydroxylation; Ketamine; Solvents | 2017 |
Ketamine and norketamine stability in whole blood at ambient and 4°C conditions.
Topics: Chromatography, Liquid; Drug Stability; Humans; Hydrophobic and Hydrophilic Interactions; Ketamine; Linear Models; Reproducibility of Results; Temperature | 2018 |
A rapid and sensitive chiral LC-MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine.
Topics: Animals; Antidepressive Agents; Brain; Calibration; Cerebrospinal Fluid; Chromatography, Liquid; Ketamine; Male; Mice; Mice, Inbred C57BL; Plasma; Reproducibility of Results; Stereoisomerism; Substance Abuse Detection; Tandem Mass Spectrometry | 2018 |
Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Helplessness, Learned; Ketamine; Male; Off-Label Use; Rats; Spermidine; Time Factors | 2018 |
Neurocognitive and behavioural performance of healthy volunteers receiving an increasing analgesic-range infusion of ketamine.
Topics: Adult; Analgesics; Behavior; Cognition; Female; Humans; Infusions, Intravenous; Ketamine; Male; Memory, Short-Term; Psychomotor Performance; Reaction Time; Young Adult | 2018 |
Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro.
Topics: Animals; Dogs; Electrophoresis, Capillary; Glucuronosyltransferase; Horses; Humans; Ketamine; Microsomes, Liver; Species Specificity; Stereoisomerism | 2018 |
Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Ketamine; Male; Models, Animal; Morphine; Oxycodone; Rats; Rats, Sprague-Dawley | 2018 |
Computer simulation of the enantioselective separation of weak bases in an online capillary electrophoresis based microanalysis configuration comprising sulfated cyclodextrin as selector.
Topics: Computer Simulation; Electrophoresis, Capillary; gamma-Cyclodextrins; Ketamine; Stereoisomerism | 2018 |
(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice.
Topics: Animals; Antidepressive Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depressive Disorder; Inflammation; Ketamine; Lipopolysaccharides; Male; Mice, Inbred C57BL; Mice, Inbred ICR | 2018 |
The effect of route of administration on the enantioselective pharmacokinetics of ketamine and norketamine in rats.
Topics: Animals; Antidepressive Agents; Area Under Curve; Chromatography, Liquid; Infusions, Intravenous; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tandem Mass Spectrometry | 2018 |
AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Dendritic Spines; Depression; Hippocampus; Ketamine; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stress, Psychological | 2018 |
[Concentrations of Ketamine and Norketamine in the Water Environment in Beijing].
Topics: Beijing; Chromatography, High Pressure Liquid; Environmental Monitoring; Ketamine; Rivers; Sewage; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2016 |
Synthesis of carbon-14 labeled ketamine and norketamine.
Topics: Carbon Radioisotopes; Chemistry Techniques, Synthetic; Copper; Cyanides; Isotope Labeling; Ketamine; Stereoisomerism | 2018 |
Is (S)-norketamine an alternative antidepressant for esketamine?
Topics: Animals; Antidepressive Agents; Depression; Humans; Ketamine | 2019 |
Sex Differences in the Pharmacokinetics of Low-dose Ketamine in Plasma and Brain of Male and Female Rats.
Topics: Animals; Brain; Estrogens; Female; Ketamine; Male; Plasma; Progesterone; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2018 |
Mechanisms of the Antidepressant Effects of Ketamine Enantiomers and Their Metabolites.
Topics: Antidepressive Agents; Ketamine; Receptors, AMPA; Stereoisomerism | 2018 |
Efficacy of the ketamine metabolite (2R,6R)-hydroxynorketamine in mice models of pain.
Topics: Animals; Disease Models, Animal; Female; Ketamine; Mice; Mice, Inbred C57BL; Neuralgia; Treatment Outcome | 2019 |
Rapid electrophoretic monitoring of the anaesthetic ketamine and its metabolite norketamine in rat blood using a contactless conductivity detector to study the pharmacokinetics.
Topics: Anesthetics; Animals; Electric Conductivity; Ketamine; Limit of Detection; Male; Rats; Rats, Wistar | 2019 |
Sex-dependent changes in ketamine-induced locomotor activity and ketamine pharmacokinetics in preweanling, adolescent, and adult rats.
Topics: Aging; Animals; Animals, Newborn; Dopamine; Excitatory Amino Acid Antagonists; Female; Hippocampus; Humans; Ketamine; Locomotion; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2019 |
A validated GC-MS method for ketamine and norketamine in hair and its use in authentic cases.
Topics: Adult; Anesthetics, Dissociative; Gas Chromatography-Mass Spectrometry; Hair; Humans; Ketamine; Limit of Detection; Substance Abuse Detection; Substance-Related Disorders; Young Adult | 2019 |
MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Intranasal; Anesthetics, Dissociative; Animals; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Ketamine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Neostriatum; Neuroprotective Agents; Parkinson Disease; Protein-Tyrosine Kinases; Receptor, trkB; Signal Transduction; Substantia Nigra; Tyrosine 3-Monooxygenase | 2020 |
Simultaneous quantitative LC-MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapy.
Topics: Amines; Calibration; Chromatography, High Pressure Liquid; Extracorporeal Membrane Oxygenation; Humans; Ketamine; Midazolam; Reproducibility of Results; Tandem Mass Spectrometry | 2020 |
Online Enantioselective Capillary Electrophoretic Method for Screening Cytochrome P450 3A4 Inhibitors.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Electrophoresis, Capillary; Humans; Ketamine; Kinetics; Mass Screening; Stereoisomerism | 2020 |
(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
Topics: Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Female; Ketamine; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate | 2020 |
Pharmacokinetics of ketamine following a short intravenous infusion to isoflurane-anesthetized New Zealand White rabbits (Oryctolagus cuniculus).
Topics: Analgesics; Anesthetics, Inhalation; Animals; Female; Infusions, Intravenous; Isoflurane; Ketamine; Prospective Studies; Rabbits | 2020 |
A Fast and Validated High Throughput Bar Adsorptive Microextraction (HT-BAµE) Method for the Determination of Ketamine and Norketamine in Urine Samples.
Topics: Adsorption; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Limit of Detection; Liquid Phase Microextraction; Reproducibility of Results; Solid Phase Microextraction; Solvents; Urine; Water | 2020 |
Structure-Activity Relationships for the Anaesthetic and Analgaesic Properties of Aromatic Ring-Substituted Ketamine Esters.
Topics: Analgesics; Anesthetics; Animals; Cyclohexanes; Down-Regulation; Esters; Inhibitory Concentration 50; Ketamine; Molecular Structure; Oximes; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2020 |
Postmortem redistribution of ketamine in ocular matrices: A study of forensic relevance.
Topics: Animals; Aqueous Humor; Chromatography, Liquid; Female; Forensic Medicine; Goats; Injections, Intravenous; Intravitreal Injections; Ketamine; Male; Models, Animal; Postmortem Changes; Rabbits; Tandem Mass Spectrometry; Vitreous Body | 2020 |
Determination of Ketamine and Norketamine in Hair and Evaluation of Polydrug Use in Ketamine Abusers Using Hair Analysis in Korea.
Topics: Hair Analysis; Humans; Ketamine; Republic of Korea; Substance Abuse Detection | 2021 |
Ketamine and Norketamine: Enantioresolution and Enantioselective Aquatic Ecotoxicity Studies.
Topics: Animals; Chromatography, Liquid; Daphnia; Ketamine; Stereoisomerism | 2022 |
Effects of long-term alcohol exposure on the pharmacokinetic profiles of ketamine and norketamine in rats.
Topics: Alcoholism; Animals; Chromatography, Liquid; Humans; Ketamine; Rats; Tandem Mass Spectrometry | 2021 |
Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers.
Topics: Adult; Female; Healthy Volunteers; Humans; Ketamine; Male; Models, Biological; Reproducibility of Results; Young Adult | 2021 |
Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses.
Topics: Adult; Apolipoprotein A-I; Female; Humans; Ketamine; Male; Proteomics; Substance-Related Disorders; Urinary Bladder; Young Adult | 2021 |
A critical point in chiral chromatography-mass spectrometry analysis of ketamine metabolites.
Topics: Animals; Chromatography, Liquid; Dogs; Ketamine; Stereoisomerism; Tandem Mass Spectrometry | 2021 |
Ketamine for Refractory Chronic Migraine: An Observational Pilot Study and Metabolite Analysis.
Topics: Adult; Analgesics; Chronic Disease; Female; Humans; Ketamine; Lidocaine; Male; Middle Aged; Migraine Disorders; Pilot Projects; Prospective Studies; Young Adult | 2021 |
Gut microbiota is involved in the antidepressant-like effect of (S)-norketamine in an inflammation model of depression.
Topics: Animals; Antidepressive Agents; Bacteria; Depression; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation; Ketamine; Lipopolysaccharides; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate | 2021 |
Identification of a novel norketamine precursor from seized powders: 2-(2-chlorophenyl)-2-nitrocyclohexanone.
Topics: Cyclohexanones; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Powders | 2022 |
Microextraction by Packed Sorbent as a Clean-up Approach for the Determination of Ketamine and Norketamine in Hair by Gas Chromatography--Tandem Mass Spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Hair; Ketamine; Limit of Detection; Reproducibility of Results; Solid Phase Microextraction; Tandem Mass Spectrometry | 2023 |
Chiral LC-MS/MS method for the simultaneous determination of (R,S)-ketamine, (R,S)-norketamine, and (2R,6R;2S,6S)-hydroxynorketamine in mouse plasma and brain.
Topics: Animals; Antidepressive Agents; Brain; Chromatography, Liquid; Ketamine; Mice; Tandem Mass Spectrometry | 2023 |
Simultaneous quantitation of ketamine, norketamine and dehydronorketamine in human milk using a novel ultra high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) assay.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; Ketamine; Lactation; Milk, Human; Reproducibility of Results; Tandem Mass Spectrometry | 2023 |