norketamine has been researched along with esketamine in 5 studies
| Studies (norketamine) | Trials (norketamine) | Recent Studies (post-2010) (norketamine) | Studies (esketamine) | Trials (esketamine) | Recent Studies (post-2010) (esketamine) |
|---|---|---|---|---|---|
| 220 | 32 | 122 | 433 | 131 | 414 |
| Protein | Taxonomy | norketamine (IC50) | esketamine (IC50) |
|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 0.0114 | |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 0.0114 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, K; Yang, C | 1 |
| Hashimoto, K | 2 |
| Aarts, L; Dahan, A; Jonkman, K; Kamp, J; Niesters, M; Olofsen, E; van Velzen, M | 1 |
| Gardier, AM; McGowan, JC; Nguyen, TML | 1 |
3 review(s) available for norketamine and esketamine
| Article | Year |
|---|---|
Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; History, 20th Century; History, 21st Century; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate | 2019 |
Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine.
Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Depression; Gastrointestinal Microbiome; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Spleen | 2020 |
CYP 450 enzymes influence (R,S)-ketamine brain delivery and its antidepressant activity.
Topics: Animals; Antidepressive Agents; Cytochrome P-450 Enzyme System; Humans; Ketamine | 2022 |
1 trial(s) available for norketamine and esketamine
| Article | Year |
|---|---|
Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis.
Topics: Adult; Anesthetics, Dissociative; Biotransformation; Computer Simulation; Cross-Over Studies; Double-Blind Method; Drug Compounding; Female; Humans; Injections, Intravenous; Ketamine; Male; Models, Theoretical; Nitroprusside; Postoperative Complications; Stereoisomerism; Young Adult | 2020 |
1 other study(ies) available for norketamine and esketamine
| Article | Year |
|---|---|
Is (S)-norketamine an alternative antidepressant for esketamine?
Topics: Animals; Antidepressive Agents; Depression; Humans; Ketamine | 2019 |