noribogaine and coronardine

To determine whether (+)-catharanthine induces sedative- or anxiolytic/anxiogenic-like activity in male mice, proper animal paradigms were used. The results showed that (+)-catharanthine induces sedative-like activity in the 63-72 mg/Kg dose range in a flumazenil-insensitive manner, but neither this effect nor anxiolytic/anxiogenic-like activity was observed at lower doses. To determine the underlying molecular mechanism of the sedative-like activity, electrophysiological and radioligand binding experiments were performed with (+)-catharanthine and (±)-18-methoxycoronaridine [(±)-18-MC] on GABA

Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; HEK293 Cells; Humans; Hypnotics and Sedatives; Ibogaine; Locomotion; Male; Maze Learning; Mice; Receptors, GABA-A