Page last updated: 2024-08-24

norharman and harman

norharman has been researched along with harman in 110 studies

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-199018 (16.36)18.7374
1990's31 (28.18)18.2507
2000's26 (23.64)29.6817
2010's24 (21.82)24.3611
2020's11 (10.00)2.80

Authors

AuthorsStudies
Allen, MS; Codding, PW; Hagen, TJ; Koehler, KF; Martin, MJ; Narayanan, K; Schindler, LR; Schultz, C; Tan, YC; Trudell, ML1
Barker, SA; Cain, M; Cook, JM; Crawley, JN; Guzman, F; Paul, SM; Rice, KC; Skolnick, P; Weber, RW1
Good, AC; Peterson, SJ; Richards, WG1
Platt, DE; Silverman, BD1
Karplus, M; So, SS1
Cosentino, ML; Hu, CQ; Ishida, J; Lee, KH; Oyama, M; Wang, HK1
Deng, Y; Duan, J; Kesuma, D; Qi, RZ; Sim, MM; Song, Y; Teng, SF; Wang, J; Wang, JH1
Fan, B; Ma, W; Xia, B; Zhang, X; Zheng, B1
Ahmad, K; Beg, Y; Cho, SJ; Muddassar, M; Pasha, FA1
Amado, Mdel R; Carrillo, AK; Galarreta, BC; Maruenda, H; Sanchez, L; Sifuentes, R1
Jiang, X; Liu, J; Peng, L; Peng, S; Zhang, X; Zhao, M; Zheng, M1
Li, C; Liu, J; Peng, S; Wang, Y; Wu, J; Zhang, X; Zhao, M; Zheng, M1
Gooyit, M; Janda, KD; Javor, S; Lustigman, S; Tricoche, N1
Cai, A; Cho, B; Giulietti, JM; Mulcahy, SP; Tate, PM1
Aaghaz, S; Jain, R; Kamal, A; Sharma, K1
Dai, JK; Dan, WJ; Wan, JB1
Chen, C; Chen, D; Chen, X; Dong, X; Gu, R; Han, F; Li, F; Li, Y; Wang, G; Wang, L; Zhang, Y1
Matsushima, T; Shirai, A; Sugimura, T; Umezawa, K1
Hayashi, K; Nagao, M; Sugimura, T1
Legraverend, C; Levitt, RC; Nebert, DW; Pelkonen, O1
Castellazzi, M; Chang, CC; Glover, TW; Trosko, JE1
Lin, DX1
Asakawa, E; Hagiwara, A; Hasegawa, R; Ito, N; Sano, M; Tanaka, H1
Bourke, CA; Carrigan, MJ; Stevens, GR1
Asakawa, E; Hagiwara, A; Hirose, M; Ito, N; Kurata, Y; Sano, M1
May, T; Rommelspacher, H; Schmidt, LG1
Adachi, J; Fujiwara, S; Mizoi, Y; Naito, T; Ninomiya, I; Yamamoto, K1
Hagiwara, A; Ito, N; Kato, T; Kurata, Y; Tanaka, H; Tsuda, H1
Bourke, CA; Carrigan, MJ; Dixon, RJ1
Lakdawalla, AA; Netrawali, MS1
Nagao, M; Ohgaki, H; Sugimura, T; Wakabayashi, K; Yamashita, K1
Bosin, TR; Faull, KF1
Nakamura, S; Oda, Y; Oki, I1
Aune, T; Holme, JA; Søderlund, E1
Barnes, WS; Horn, CL; Weisburger, JH1
Hayashi, K1
Oikawa, A; Sugawara, R; Tada, M; Tohda, H1
Nakasato, F; Nakayasu, M; Sakamoto, H; Sugimura, T; Terada, M1
Oderfeld-Nowak, B; Rommelspacher, H; Skup, M1
Dudai, Y; Sherman-Gold, R1
Keller, H; Riebe, M; Westphal, K1
Hansen, J; Madle, E; Obe, G; Ristow, H1
Berger, G; Blum, S; Conrad, C; Hannemann, L; Marks, C; Müller, C; Rommelspacher, H; Schnapper, C; Specht, M; Spies, CD1
de Meester, C1
Kühn-Velten, WN1
May, T; Rommelspacher, H; Salewski, B1
Greube, A; Heineke, D; Lehmann, J; May, T; Rommelspacher, H; Strauss, S1
Dammann, G; Ladewig, D; Rommelspacher, H; Stohler, R1
Funayama, Y; Hasegawa, S; Nagao, M; Nishio, K; Ohira, T; Saijo, N; Shimoi, K; Wakabayashi, K1
Dufeu, P; Rommelspacher, H; Schmidt, LG1
Galceran, MT; Moyano, E; Pais, P; Puignou, L1
Lesch, OM; Walter, H1
Böning, J; Riederer, P; Rommelspacher, H; Wiesbeck, GA; Wodarz, N1
Grosse, H; Kuhn, W; Müller, T; Rommelspacher, H2
Baum, SS; Hill, R; Rommelspacher, H1
Neuhaus, P; Neuhaus, R; Platzgummer, W; Rommelspacher, H; Schmidt, LG; Wiest, M1
Damm, H; Klinker, JF; Rommelspacher, H; Seifert, R1
Arvidsson, P; Jägerstad, M; Skog, K; Solyakov, A1
Sugimura, T1
Goto, S; Ishihara, J; Sinha, R; Sugimura, T; Totsuka, Y; Ushiyama, H; Wakabayashi, K1
Fukazawa, H; Nakano, K; Shiozawa, T; Suyama, K; Terao, Y; Uchida, M; Wakabayashi, K1
Herraiz, T3
Pineda, J; Ruiz-Durántez, E; Ugedo, L1
Diem, S; Gutsche, B; Herderich, M1
Kloft, C; Meier-Henco, M; Rommelspacher, H; Smolka, M1
Galisteo, J; Herraiz, T2
Pfau, W; Skog, K1
Asamoto, M; Hirose, M; Ichihara, T; Imaida, K; Kawabe, M; Miyashita, K; Ogiso, T; Shirai, T; Tamano, S1
Bianchi, F; Careri, M; Corradini, C; Elviri, L; Mangia, A; Zagnoni, I1
Chait, A; de Beaurepaire, R; Molimard, R; Rat, P; Touiki, K1
Chaparro, C; Herraiz, T1
Farzin, D; Mansouri, N1
Alves, RC; Casal, S; Oliveira, BP1
del Castillo, B; León, AG; Martín, MA; Olives, AI1
Jin, CM; Lee, JJ; Lee, MK; Lim, SC; Yang, YJ1
Gibis, M; Jautz, U; Morlock, GE1
Erra-Balsells, R; Nonami, H; Tarzi, OI1
Arán, VJ; Guillén, H; Herraiz, T1
Chen, X; Cromer, BA; Lynch, JW1
Crotti, AE; Gates, PJ; Lopes, JL; Lopes, NP1
Arib, O; Chait, A; de Beaurepaire, R; Faure, P; Molimard, R; Rat, P1
Dixon Clarke, SE; Ramsay, RR1
Baryar, F; Farzin, D; Haghparast, A; Mansouri, N; Motaman, S1
Castañeda, G; De Andrés, F; Ríos, A; Sánchez-Rojas, JL; Zougagh, M1
Liao, GZ; Wang, GY; Xu, XL; Zhang, YJ; Zhou, GH1
Alam, SM; Alothman, ZA; Lee, SH; Siddiqui, MR; Wabaidur, SM1
Gibis, M; Weiss, J1
Domonkos, C; Fitos, I; Visy, J; Zsila, F1
Abu Ghazaleh, H; Hudson, AL; Lalies, MD; Nutt, DJ1
Mildner-Szkudlarz, S; Przygoński, K; Wojtowicz, E; Zawirska-Wojtasiak, R1
Alarifi, A; Chetna, J; Kamal, A; Manasa, KL; Sathish, M; Srinivasulu, V; Tangella, Y1
Agim, ZS; Cannon, JR; Cruz-Hernandez, A; McCabe, GP; Montenegro, PC; Rochet, JC1
Jain, RB1
Boguś, MI; Kaczmarek, A; Kazek, M; Wrońska, AK1
Busquets, R; Khan, MR; Naushad, M; Puignou, L1
Beer, F; Bunzel, D; Bunzel, M; Franz, CMAP; Huch, M; Kulling, SE; Urbat, F1
Chen, A; Chen, F; Lao, F; Liao, X; Wang, X; Xu, L; Xu, Z; Yang, S1
Mildner-Szkudlarz, S; Piechowska, P; Zawirska-Wojtasiak, R1
Ma, YX; Wang, XD; Xi, J; Zhang, CX; Zhao, TP1
Chen, J; He, Z; Jiao, Y; Li, Y; Liu, G; Qin, F; Quan, W; Wang, Z; Xue, C; Zeng, M1
Bajerska, J; Fedoruk-Wyszomirska, A; Gurda, D; Kubicka, W; Mildner-Szkudlarz, S; Piechowska, P; Przygoński, K; Wojtowicz, E; Wyszko, E; Zawirska-Wojtasiak, R1
Harris, AC; LeSage, MG; Muelken, P1
Hawkey, AB; Hoeng, J; Koshibu, K; Levin, ED; Peitsch, MC1
Janoszka, B; Nowak, A; Śnieżek, E; Szumska, M1
Cui, Z; Li, Y; Liu, W; Shi, L; Yang, Z1
Aksenov, AV; Aksenov, DA; Aksenov, NA; Aksenova, IV; Aleksandrova, EV; Arutiunov, NA; Rubin, M1

Reviews

8 review(s) available for norharman and harman

ArticleYear
β-Carbolines as potential anticancer agents.
    European journal of medicinal chemistry, 2021, Apr-15, Volume: 216

    Topics: Antineoplastic Agents; Carbolines; Cyclin-Dependent Kinases; DNA Topoisomerases; Humans; Intercalating Agents; Neoplasms; Plants; Proto-Oncogene Proteins B-raf; Tubulin

2021
Natural and synthetic β-carboline as a privileged antifungal scaffolds.
    European journal of medicinal chemistry, 2022, Feb-05, Volume: 229

    Topics: Animals; Antifungal Agents; Biological Products; Carbolines; Drug Discovery; Female; Humans; Male; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycoses; Protein Binding; Signal Transduction; Structure-Activity Relationship

2022
Possible genotoxic carcinogens in foods in relation to cancer causation.
    Seminars in oncology, 1983, Volume: 10, Issue:3

    Topics: Animals; Breast Neoplasms; Carbolines; Carcinogens, Environmental; Cattle; Colonic Neoplasms; Cooking; Food; Harmine; Head and Neck Neoplasms; Humans; Imidazoles; Male; Meat; Mutagens; Neoplasms; Nitrates; Nitrites; Nitrosamines; Prostatic Neoplasms

1983
Genotoxic potential of beta-carbolines: a review.
    Mutation research, 1995, Volume: 339, Issue:3

    Topics: Animals; Carbolines; DNA; Drug Interactions; Harmine; Humans; Mutagenicity Tests; Mutagens

1995
New 'state' markers for the detection of alcoholism.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1996, Volume: 31 Suppl 1

    Topics: Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Biomarkers; Carbolines; Erythrocyte Indices; Harmine; Humans; Sensitivity and Specificity; Transferrin

1996
Exposure to beta-carbolines norharman and harman.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Mar-25, Volume: 802, Issue:1

    Topics: Biological Availability; Biomarkers; Carbolines; Harmine; Humans

2004
Dietary inhibitors of monoamine oxidase A.
    Journal of neural transmission (Vienna, Austria : 1996), 2011, Volume: 118, Issue:7

    Topics: Animals; Anxiety Disorders; Carbolines; Depressive Disorder; Harmine; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quercetin; Serotonin

2011
Bioactive β-Carbolines in Food: A Review.
    Nutrients, 2019, Apr-11, Volume: 11, Issue:4

    Topics: Animals; Brain; Brain Chemistry; Carbolines; Essential Tremor; Food; Food Handling; Harmine; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Plant Extracts

2019

Trials

1 trial(s) available for norharman and harman

ArticleYear
The levels of norharman are high enough after smoking to affect monoamineoxidase B in platelets.
    European journal of pharmacology, 2002, Apr-19, Volume: 441, Issue:1-2

    Topics: Adult; Blood Platelets; Carbolines; Harmine; Humans; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Smoking; Time Factors

2002

Other Studies

101 other study(ies) available for norharman and harman

ArticleYear
Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:9

    Topics: Binding Sites; Carbolines; Chemical Phenomena; Chemistry; Computer Simulation; Ligands; Models, Chemical; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship

1990
Beta-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Carbolines; Chemical Phenomena; Chemistry; Diazepam; Drug Interactions; Indoles; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A

1982
QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
    Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20

    Topics: Carbolines; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Imidazoles; Indoles; Molecular Structure; Pyridines; Structure-Activity Relationship

1993
Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.
    Journal of medicinal chemistry, 1996, May-24, Volume: 39, Issue:11

    Topics: Adrenal Cortex Hormones; Binding Sites; Mathematics; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Predictive Value of Tests; Steroids; Structure-Activity Relationship; Testosterone

1996
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Cholinesterase Inhibitors; Dopamine beta-Hydroxylase; Drug Design; Enzyme Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Conformation; Molecular Structure; Neural Networks, Computer; Phosphorylases; Receptors, Aryl Hydrocarbon; Static Electricity; Structure-Activity Relationship

1997
Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.
    Journal of natural products, 2001, Volume: 64, Issue:7

    Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Furans; Harmine; Humans; Lignans; Lymphocytes; Molecular Structure; Plants, Medicinal; Structure-Activity Relationship

2001
Beta-carbolines as specific inhibitors of cyclin-dependent kinases.
    Bioorganic & medicinal chemistry letters, 2002, Apr-08, Volume: 12, Issue:7

    Topics: Carbolines; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Protein Serine-Threonine Kinases

2002
Quantitative structure-activity relationship studies of a series of non-benzodiazepine structural ligands binding to benzodiazepine receptor.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:7

    Topics: Ligands; Quantitative Structure-Activity Relationship; Receptors, GABA-A

2008
3D and quantum QSAR of non-benzodiazepine compounds.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:11

    Topics: Benzodiazepines; Carbolines; Imaging, Three-Dimensional; Imidazoles; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Pyrimidines; Quantitative Structure-Activity Relationship; Software

2008
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.
    Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14

    Topics: Animals; Biological Products; Enzyme Inhibitors; Flavins; Harmaline; Indole Alkaloids; Leishmania; NADH, NADPH Oxidoreductases; Quinolines; Trypanocidal Agents; Trypanosoma cruzi

2008
A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency.
    Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8

    Topics: Amino Acids; Animals; Carbolines; Fibrinolytic Agents; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Swine

2010
A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:11

    Topics: Animals; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Drug Design; Fibrinolytic Agents; Hydrazines; Male; Models, Molecular; Molecular Conformation; Platelet Aggregation; Platelet Aggregation Inhibitors; Quantitative Structure-Activity Relationship; Rats; Swine; Thrombosis

2011
Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting.
    ACS medicinal chemistry letters, 2015, Mar-12, Volume: 6, Issue:3

    Topics:

2015
DNA-binding studies of the natural β-carboline eudistomin U.
    Bioorganic & medicinal chemistry letters, 2016, 10-01, Volume: 26, Issue:19

    Topics: Calorimetry, Differential Scanning; Carbolines; Circular Dichroism; DNA; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

2016
Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.
    Journal of medicinal chemistry, 2022, 08-25, Volume: 65, Issue:16

    Topics: Animals; Antidepressive Agents; Carbolines; Enzyme Inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Tryptophan Oxygenase

2022
Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives.
    Proceedings of the National Academy of Sciences of the United States of America, 1978, Volume: 75, Issue:2

    Topics: 2-Acetylaminofluorene; Alkaloids; Carbolines; Drug Synergism; Fluorenes; Harmine; Microsomes, Liver; Mutagens; Salmonella typhimurium

1978
Interactions of norharman and harman with DNA.
    Nucleic acids research, 1977, Volume: 4, Issue:11

    Topics: Alkaloids; Binding Sites; Carbolines; Coliphages; DNA; DNA, Circular; DNA, Superhelical; DNA, Viral; Harmine; Nucleic Acid Conformation; Spectrometry, Fluorescence; Spectrum Analysis

1977
Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture.
    Biochemical and biophysical research communications, 1977, Dec-21, Volume: 79, Issue:4

    Topics: Alkaloids; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Carbolines; Cells, Cultured; DNA; Enzyme Induction; Harmine; Liver; Mutagens

1977
Effects of harman and norharman on spontaneous and ultraviolet light-induced mutagenesis in cultured Chinese hamster cells.
    Cancer research, 1978, Volume: 38, Issue:12

    Topics: Alkaloids; Carbolines; Cell Survival; Cells, Cultured; DNA Repair; Harmine; Mutation; Tryptophan; Ultraviolet Rays

1978
[Effects of harman and norharman on aflatoxin B1 and aminopyrine metabolism by phenobarbital and 3-methylcholanthrene-induced rat liver microsomes].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 1992, Volume: 26, Issue:4

    Topics: Aflatoxin B1; Aminopyrine N-Demethylase; Animals; Carbolines; Harmine; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar

1992
Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:9

    Topics: Animals; Carbolines; Carcinogens; Carcinoma, Renal Cell; Diethylnitrosamine; Harmine; Kidney Neoplasms; Male; Precancerous Conditions; Rats; Rats, Inbred F344

1992
Locomotor effects in sheep of alkaloids identified in Australian Tribulus terrestris.
    Australian veterinary journal, 1992, Volume: 69, Issue:7

    Topics: Animals; Carbolines; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Female; Harmine; Locomotion; Plant Extracts; Plant Poisoning; Plants, Edible; Sheep; Sheep Diseases; Spectrophotometry, Ultraviolet

1992
Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats.
    Toxicologic pathology, 1992, Volume: 20, Issue:2

    Topics: Acetylglucosamine; Animals; Bromodeoxyuridine; Carbolines; DNA; Drinking; Harmine; Kidney Diseases; Kidney Tubules; L-Lactate Dehydrogenase; Male; Microvilli; Organ Size; Phagocytosis; Rats; Rats, Inbred F344; Urination

1992
Plasma norharman (beta-carboline) levels are elevated in chronic alcoholics.
    Alcoholism, clinical and experimental research, 1991, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Alcoholism; Carbolines; Chromatography, High Pressure Liquid; Ethanol; Female; Follow-Up Studies; Harmine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Psychopathology; Substance Withdrawal Syndrome

1991
Determination of beta-carbolines in foodstuffs by high-performance liquid chromatography and high-performance liquid chromatography-mass spectrometry.
    Journal of chromatography, 1991, Feb-01, Volume: 538, Issue:2

    Topics: Acetaldehyde; Alcoholic Beverages; Carbolines; Chromatography, High Pressure Liquid; Ethanol; Food Analysis; Harmine; Ions; Mass Spectrometry

1991
Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman.
    Journal of toxicology and environmental health, 1990, Volume: 29, Issue:2

    Topics: Alkaloids; Animals; Body Weight; Carbolines; Cocarcinogenesis; Diethylnitrosamine; Glutathione Transferase; Harmine; Liver; Male; Rats; Rats, Inbred F344

1990
Upper motor neurone effects in sheep of some beta-carboline alkaloids identified in zygophyllaceous plants.
    Australian veterinary journal, 1990, Volume: 67, Issue:7

    Topics: Alkaloids; Animals; Carbolines; Female; Harmaline; Harmine; Locomotion; Motor Neurons; Plants, Toxic; Sheep

1990
Mutagenicity, comutagenicity, and antimutagenicity of erythrosine (FD and C red 3), a food dye, in the Ames/Salmonella assay.
    Mutation research, 1988, Volume: 204, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Azides; Benzo(a)pyrene; Carbolines; Cecum; DNA Damage; DNA Repair; Drug Interactions; Erythrosine; Ethidium; Fluoresceins; Food Coloring Agents; Harmine; Male; Methyl Methanesulfonate; Microsomes, Liver; Mitomycin; Mitomycins; Mutation; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium Azide

1988
DNA adducts formed by the comutagens harman and norharman in various tissues of mice.
    Cancer letters, 1988, Volume: 42, Issue:3

    Topics: Alkaloids; Animals; Carbolines; DNA; DNA Damage; Gastric Mucosa; Harmine; Intestine, Large; Kidney; Liver; Mice; Tissue Distribution

1988
Measurement of beta-carbolines by high-performance liquid chromatography with fluorescence detection.
    Journal of chromatography, 1988, Jul-15, Volume: 428, Issue:2

    Topics: Animals; Carbolines; Chromatography, High Pressure Liquid; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Harmine; Male; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence

1988
Harman and norharman induce SOS responses and frameshift mutations in bacteria.
    Mutation research, 1988, Volume: 208, Issue:1

    Topics: Alkaloids; Carbolines; DNA Repair; Harmine; Mutagenicity Tests; Mutagens; Mutation; Salmonella typhimurium; SOS Response, Genetics

1988
Effects of harman and norharman on the metabolism and genotoxicity of 2-acetylaminofluorene in cultured rat hepatocytes.
    Cell biology and toxicology, 1985, Volume: 1, Issue:3

    Topics: 2-Acetylaminofluorene; Alkaloids; Animals; Carbolines; Cells, Cultured; DNA; DNA Repair; Drug Synergism; Harmine; Liver; Male; Mutagens; Rats; Rats, Inbred Strains

1985
[Effects of harman and norharman on the metabolism of aniline and p-dimethylaminoazobenzene (author's transl)].
    Nihon eiseigaku zasshi. Japanese journal of hygiene, 1981, Volume: 36, Issue:2

    Topics: Alkaloids; Aniline Compounds; Aniline Hydroxylase; Animals; Carbolines; Harmine; Male; Microsomes, Liver; p-Dimethylaminoazobenzene; Rats

1981
Actions of amino-beta-carbolines on induction of sister-chromatid exchanges.
    Mutation research, 1983, Volume: 116, Issue:2

    Topics: Animals; Carbolines; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; Harmine; Indoles; Ovary; Sister Chromatid Exchange; Structure-Activity Relationship

1983
Mutagenic activity of norharman and harman in Chinese hamster lung cells in assays with diphtheria toxin resistance as a marker.
    Cancer letters, 1983, Volume: 17, Issue:3

    Topics: Alkaloids; Animals; Biotransformation; Carbolines; Cell Line; Cell Survival; Cricetinae; Cricetulus; Diphtheria Toxin; Drug Resistance; Female; Harmine; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Ovary

1983
In vitro studies on the effect of beta-carbolines on the activities of acetylcholinesterase and choline acetyltransferase and on the muscarinic receptor binding of the rat brain.
    Journal of neurochemistry, 1983, Volume: 41, Issue:1

    Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Carbolines; Cattle; Choline O-Acetyltransferase; Erythrocytes; Harmaline; Harmine; Indoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Structure-Activity Relationship

1983
beta-Carboline binding to deoxycholate solubilized benzodiazepine receptors from calf cerebral cortex.
    Neuroscience letters, 1981, Nov-04, Volume: 26, Issue:3

    Topics: Alkaloids; Animals; Benzodiazepines; Carbolines; Cattle; Cerebral Cortex; Deoxycholic Acid; Flunitrazepam; Harmine; Receptors, Drug; Solubility; Statistics as Topic; Tritium

1981
Test-condition-dependent influence of harman and nonharman on benzo[a]pyrene mutagenesis in Salmonella.
    Mutation research, 1982, Volume: 104, Issue:1-3

    Topics: Alkaloids; Animals; Benzopyrenes; Biotransformation; Carbolines; Dose-Response Relationship, Drug; Harmine; In Vitro Techniques; Liver; Mice; Mutagenicity Tests; Mutagens; Rats; Salmonella typhimurium

1982
Harman and norharman: induction of sister-chromatid exchanges in human peripheral lymphocytes in vitro and interaction with isolated DNA.
    Mutation research, 1981, Volume: 90, Issue:4

    Topics: Alkaloids; Carbolines; Chromosome Aberrations; Crossing Over, Genetic; DNA; Harmine; Humans; Lymphocytes; Sister Chromatid Exchange; Structure-Activity Relationship; Transcription, Genetic; Triaziquone

1981
Beta-carbolines in chronic alcoholics undergoing elective tumor resection.
    Alcoholism, clinical and experimental research, 1995, Volume: 19, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Biomarkers; Carbolines; Critical Care; Esophageal Neoplasms; Harmine; Humans; Male; Middle Aged; Otorhinolaryngologic Neoplasms; Postoperative Complications; Risk Factors

1995
Norharman (beta-carboline) as a potent inhibitory ligand for steroidogenic cytochromes P450 (CYP11 and CYP17).
    European journal of pharmacology, 1993, Nov-30, Volume: 250, Issue:1

    Topics: Adrenal Glands; Animals; Binding, Competitive; Carbolines; Harmine; Male; Microsomes; Mitochondria; Progesterone; Rats; Spectrophotometry, Ultraviolet; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Testis

1993
Harman (1-methyl-beta-carboline) is a natural inhibitor of monoamine oxidase type A in rats.
    European journal of pharmacology, 1994, Jan-24, Volume: 252, Issue:1

    Topics: Animals; Beer; Binding Sites; Brain; Carbolines; Harmine; Kidney; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocardium; Pargyline; Rats; Rats, Wistar; Tissue Distribution; Wine

1994
Comparison of the in vitro binding characteristics of the beta-carbolines harman and norharman in rat brain and liver and in bovine adrenal medulla.
    Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 349, Issue:3

    Topics: Adrenal Medulla; Animals; Brain; Carbolines; Cattle; Harmine; In Vitro Techniques; Liver; Male; Rats; Rats, Wistar; Subcellular Fractions; Temperature

1994
[Beta-carbolines (harman/norharman) are increased in heroin dependent patients].
    Therapeutische Umschau. Revue therapeutique, 1993, Volume: 50, Issue:3

    Topics: Adult; Carbolines; Female; Harmine; Heroin Dependence; Humans; Male; Methadone; Substance Withdrawal Syndrome

1993
Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities.
    Mutation research, 1996, Feb-01, Volume: 349, Issue:2

    Topics: Breast Neoplasms; Carbolines; Carcinoma, Small Cell; Cell Line; Enzyme Inhibitors; Female; Harmine; Humans; Kinetics; Mutagens; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1996
Harman and norharman in alcoholism: correlations with psychopathology and long-term changes.
    Alcoholism, clinical and experimental research, 1996, Volume: 20, Issue:1

    Topics: Adult; Alcoholism; Anxiety; Carbolines; Depression; Ethanol; Harmine; Humans; Male; Middle Aged; Motivation; Self Medication

1996
Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectrometry.
    Journal of chromatography. A, 1996, Apr-12, Volume: 730, Issue:1-2

    Topics: Amines; Animals; Calibration; Carbolines; Cattle; Chromatography, High Pressure Liquid; Harmine; Heterocyclic Compounds; Mass Spectrometry; Meat; Mutagens

1996
Excretion of beta-carbolines harman and norharman in 24-hour urine of chronic alcoholics during withdrawal and controlled abstinence.
    Alcoholism, clinical and experimental research, 1996, Volume: 20, Issue:4

    Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Biomarkers; Carbolines; Harmine; Humans; Male; Middle Aged; Motivation; Patient Admission; Personality Inventory; Treatment Outcome

1996
Plasma harman and norharman in Parkinson's disease.
    Journal of neural transmission. Supplementum, 1995, Volume: 46

    Topics: Aged; Aged, 80 and over; Carbolines; Case-Control Studies; Female; Harmine; Humans; Male; Middle Aged; Neurotoxins; Parkinson Disease

1995
Harman-induced changes of extracellular concentrations of neurotransmitters in the nucleus accumbens of rats.
    European journal of pharmacology, 1996, Oct-24, Volume: 314, Issue:1-2

    Topics: Animals; Carbolines; Dopamine; Harmine; Male; Microdialysis; Neurotoxins; Nucleus Accumbens; Rats; Rats, Wistar; Serotonin

1996
Long-term changes of markers of alcoholism after orthotopic liver transplantation (OLT).
    Transplantation, 1996, Nov-27, Volume: 62, Issue:10

    Topics: Adult; Alcoholism; Analysis of Variance; Carbolines; Harmine; Humans; Liver Diseases, Alcoholic; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Neurotoxins; Time Factors

1996
Elevated levels of harman and norharman in cerebrospinal fluid of parkinsonian patients.
    Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:12

    Topics: Adult; Aged; Carbolines; Case-Control Studies; Female; Harmine; Humans; Male; Middle Aged; Neurotoxins; Parkinson Disease

1996
Activation by beta-carbolines of G-proteins in HL-60 membranes and the bovine retinal G-protein transducin in a receptor-independent manner.
    Biochemical pharmacology, 1997, Jun-01, Volume: 53, Issue:11

    Topics: Carbolines; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Harmine; HL-60 Cells; Humans; Intercellular Signaling Peptides and Proteins; Peptides; Structure-Activity Relationship; Transducin; Wasp Venoms

1997
Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectrometry.
    Journal of chromatography. A, 1998, Apr-17, Volume: 803, Issue:1-2

    Topics: Amines; Animals; Carbolines; Carcinogens; Cooking; Gas Chromatography-Mass Spectrometry; Harmine; Heterocyclic Compounds; Hot Temperature; Meat; Meat Products; Mutagens; Reindeer; Surface Properties; Swine

1998
A new concept of co-mutagenicity from a phenomenon forgotten for the past two decades: is it more important than previously expected?
    Environmental health perspectives, 1998, Volume: 106, Issue:11

    Topics: Animals; Carbolines; Drug Synergism; Harmine; Mutagenicity Tests; Mutagens; Salmonella typhimurium

1998
Quantification of the co-mutagenic beta-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Carbolines; Food; Harmine; Humans; Mutagens; Tobacco Smoke Pollution

1999
Chlorination of harman and norharman with sodium hypochlorite and co-mutagenicity of the chlorinated products.
    Mutation research, 2000, Oct-31, Volume: 470, Issue:2

    Topics: Biotransformation; Carbolines; Harmine; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Sodium Hypochlorite

2000
Tetrahydro-beta-carboline-3-carboxylic acid compounds in fish and meat: possible precursors of co-mutagenic beta-carbolines norharman and harman in cooked foods.
    Food additives and contaminants, 2000, Volume: 17, Issue:10

    Topics: Animals; Carbolines; Cattle; Chromatography, High Pressure Liquid; Food Handling; Food Preservation; Harmine; Meat; Mutagens; Seafood; Swine

2000
Stimulatory effect of harmane and other beta-carbolines on locus coeruleus neurons in anaesthetized rats.
    Neuroscience letters, 2001, Aug-10, Volume: 308, Issue:3

    Topics: Anesthesia; Animals; Carbolines; Electrophysiology; Harmaline; Harmine; Imidazoline Receptors; Locus Coeruleus; Male; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Vagotomy

2001
Degradation of tetrahydro-beta-carbolines in the presence of nitrite: HPLC-MS analysis of the reaction products.
    Journal of agricultural and food chemistry, 2001, Volume: 49, Issue:12

    Topics: Carbolines; Chromatography, High Pressure Liquid; Food Analysis; Harmine; Kinetics; Mass Spectrometry; Molecular Conformation; Nitrites

2001
Identification and occurrence of the bioactive beta-carbolines norharman and harman in coffee brews.
    Food additives and contaminants, 2002, Volume: 19, Issue:8

    Topics: Alkaloids; Carbolines; Chromatography, High Pressure Liquid; Coffee; Food Contamination; Harmine; Mass Spectrometry

2002
Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay.
    Free radical research, 2002, Volume: 36, Issue:8

    Topics: Antioxidants; Benzothiazoles; Carbolines; Cations; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Food Analysis; Free Radicals; Gas Chromatography-Mass Spectrometry; Harmine; Indicators and Reagents; Models, Chemical; Sulfonic Acids; Time Factors

2002
Relative exposure to beta-carbolines norharman and harman from foods and tobacco smoke.
    Food additives and contaminants, 2004, Volume: 21, Issue:11

    Topics: Carbolines; Chromatography, High Pressure Liquid; Environmental Exposure; Food Analysis; Food Contamination; Food Handling; Harmine; Mutagens; Neurotoxins; Nicotiana; Smoke

2004
Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.
    The Journal of toxicological sciences, 2005, Volume: 30, Issue:1

    Topics: Amitrole; Animals; Carbolines; Harmine; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Sodium Nitrite; Weight Gain

2005
Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Oct-25, Volume: 825, Issue:2

    Topics: Acetonitriles; Amines; Buffers; Carbolines; Chromatography, Liquid; Formates; Harmine; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; Quinolines; Quinoxalines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2005
Harmane inhibits serotonergic dorsal raphe neurons in the rat.
    Psychopharmacology, 2005, Volume: 182, Issue:4

    Topics: Action Potentials; Analysis of Variance; Animals; Carbolines; Citalopram; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Harmine; Male; Neurons; Neurotoxins; Nicotine; Nicotinic Agonists; Oxazoles; Phenethylamines; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin; Serotonin Antagonists

2005
Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee.
    Life sciences, 2006, Jan-18, Volume: 78, Issue:8

    Topics: Carbolines; Chromatography, High Pressure Liquid; Coffee; Harmine; Humans; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization

2006
Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:5

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; GABA Modulators; Harmine; Male; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Reserpine; Swimming; Sympatholytics

2006
Factors influencing the norharman and harman contents in espresso coffee.
    Journal of agricultural and food chemistry, 2007, Mar-07, Volume: 55, Issue:5

    Topics: Carbolines; Coffea; Coffee; Food Handling; Harmine; Hot Temperature; Mutagens; Neurotoxins; Pressure; Seeds; Species Specificity; Time Factors

2007
Influence of the presence of methyl cyclodextrins in high-performance liquid chromatography mobile phases on the separation of beta-carboline alkaloids.
    Journal of chromatography. A, 2008, May-30, Volume: 1192, Issue:2

    Topics: beta-Cyclodextrins; Carbolines; Chromatography, High Pressure Liquid; Harmine; Indicators and Reagents; Reference Standards; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

2008
Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Animals; Antiparkinson Agents; Apoptosis; Aromatic-L-Amino-Acid Decarboxylases; Blotting, Northern; Calcium; Carbolines; Cell Survival; Cyclic AMP; Dopamine; Flow Cytometry; Harmine; In Situ Nick-End Labeling; Levodopa; Membrane Potentials; Mitochondrial Membranes; PC12 Cells; Rats; RNA; Tetrazolium Salts; Thiazoles; Tyrosine 3-Monooxygenase

2008
Quantification of heterocyclic aromatic amines in fried meat by HPTLC/UV-FLD and HPLC/UV-FLD: a comparison of two methods.
    Journal of agricultural and food chemistry, 2008, Jun-25, Volume: 56, Issue:12

    Topics: Amines; Animals; Carbolines; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Harmine; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat; Mutagens; Quinoxalines

2008
The effect of temperature on the stability of compounds used as UV-MALDI-MS matrix: 2,5-dihydroxybenzoic acid, 2,4,6-trihydroxyacetophenone, alpha-cyano-4-hydroxycinnamic acid, 3,5-dimethoxy-4-hydroxycinnamic acid, nor-harmane and harmane.
    Journal of mass spectrometry : JMS, 2009, Volume: 44, Issue:2

    Topics: Acetophenones; Carbolines; Coumaric Acids; Gentisates; Harmine; Hot Temperature; Magnetic Resonance Spectroscopy; Phase Transition; Photochemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2009
Oxidative metabolism of the bioactive and naturally occurring beta-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes.
    Chemical research in toxicology, 2008, Volume: 21, Issue:11

    Topics: Carbolines; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Harmine; Humans; Hydroxylation; Microsomes, Liver; Oxidation-Reduction

2008
Molecular determinants of beta-carboline inhibition of the glycine receptor.
    Journal of neurochemistry, 2009, Volume: 110, Issue:5

    Topics: Binding Sites; Carbolines; Cell Line; Harmine; Humans; Mutagenesis, Site-Directed; Mutation; Protein Structure, Secondary; Protein Subunits; Receptors, Glycine; Recombinant Proteins

2009
Electrospray MS-based characterization of beta-carbolines--mutagenic constituents of thermally processed meat.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:3

    Topics: Carbolines; Food Analysis; Food Handling; Food Technology; Harmine; Hot Temperature; Meat; Mutagens; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Water

2010
Electrophysiological characterization of harmane-induced activation of mesolimbic dopamine neurons.
    European journal of pharmacology, 2010, Mar-10, Volume: 629, Issue:1-3

    Topics: Animals; Carbolines; Dopamine; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Harmine; Male; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area

2010
Effects of harmane and other β-carbolines on apomorphine-induced licking behavior in rat.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 98, Issue:2

    Topics: Animals; Apomorphine; Carbolines; Corpus Striatum; Dopamine Agonists; Drug Interactions; Flumazenil; Harmine; Male; Rats; Rats, Wistar; Receptors, GABA-A; Reserpine; Stereotyped Behavior

2011
Screening of non-polar heterocyclic amines in urine by microextraction in packed sorbent-fluorimetric detection and confirmation by capillary liquid chromatography.
    Talanta, 2011, Feb-15, Volume: 83, Issue:5

    Topics: Carbolines; Chromatography, Liquid; Fluorescence; Harmine; Heterocyclic Compounds; Humans; Molecular Structure; Time Factors

2011
Formation of heterocyclic amines during cooking of duck meat.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2012, Volume: 29, Issue:11

    Topics: Amines; Animals; Carbolines; China; Chromatography, High Pressure Liquid; Cooking; Ducks; Food Contamination; Harmine; Heterocyclic Compounds; Hot Temperature; Imidazoles; Maillard Reaction; Meat; Microwaves; Mutagens; Quinolines; Quinoxalines; Solid Phase Extraction; Time Factors

2012
Second derivative synchronous fluorimetric method for simultaneous determination of harman and norharman in coffee samples.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013, Volume: 110

    Topics: Carbolines; Coffee; Harmine; Limit of Detection; Neurotoxins; Spectrometry, Fluorescence

2013
Formation of heterocyclic amines in salami and ham pizza toppings during baking of frozen pizza.
    Journal of food science, 2013, Volume: 78, Issue:6

    Topics: Amines; Animals; Carbolines; Chromatography, High Pressure Liquid; Color; Consumer Behavior; Cooking; Freezing; Harmine; Hot Temperature; Humans; Imidazoles; Maillard Reaction; Meat Products; Quinoxalines; Swine; Taste

2013
Fatty acid modulated human serum albumin binding of the β-carboline alkaloids norharmane and harmane.
    Molecular pharmaceutics, 2013, Dec-02, Volume: 10, Issue:12

    Topics: Alkaloids; Binding Sites; Carbolines; Fatty Acids; Harmine; Humans; Hydrogen-Ion Concentration; Ligands; Protein Binding; Serum Albumin

2013
Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases.
    Biochemical and biophysical research communications, 2014, Aug-15, Volume: 451, Issue:1

    Topics: Ascorbic Acid; Carbolines; Enzyme Inhibitors; Harmine; Heme; Horseradish Peroxidase; Hydroxylamine; Kinetics; Lactoperoxidase; Oxidation-Reduction; Peroxidase; Peroxidases; Sodium Azide; Tryptophan

2014
The modulatory action of harmane on serotonergic neurotransmission in rat brain.
    Brain research, 2015, Feb-09, Volume: 1597

    Topics: Animals; Calcium; Calcium Chelating Agents; Carbolines; Cerebral Cortex; Dopamine; Dose-Response Relationship, Drug; Egtazic Acid; Harmine; Ions; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Pargyline; Potassium; Rats, Wistar; Serotonin; Serotonin Agents; Synaptic Transmission; Tissue Culture Techniques

2015
Bioactive β-carbolines norharman and harman in traditional and novel raw materials for chicory coffee.
    Food chemistry, 2015, May-15, Volume: 175

    Topics: Beverages; Carbolines; Cichorium intybus; Coffee; Harmine; Hot Temperature

2015
PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I.
    Organic & biomolecular chemistry, 2015, Aug-28, Volume: 13, Issue:32

    Topics: Acetates; Carbolines; Decarboxylation; Harmine; Iodobenzenes; Molecular Structure; Oxidation-Reduction

2015
Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons.
    Neurotoxicology, 2018, Volume: 65

    Topics: Amines; Animals; Carbolines; Dopaminergic Neurons; Dose-Response Relationship, Drug; Harmine; Heterocyclic Compounds, 3-Ring; Mesencephalon; Molecular Structure; Nerve Degeneration; Neurites; Neurons; Primary Cell Culture; Quinolines; Quinoxalines; Rats

2018
Concentrations of selected heterocyclic aromatic amines among US population aged ≥ 6 years: data from NHANES 2013-2014.
    Environmental science and pollution research international, 2018, Volume: 25, Issue:20

    Topics: Adolescent; Adult; Aged; Air Pollution, Indoor; Carbolines; Child; Environmental Exposure; Female; Harmine; Humans; Imidazoles; Male; Middle Aged; Nutrition Surveys; Racial Groups; Tobacco Smoke Pollution; United States; Young Adult

2018
Harman and norharman, metabolites of entomopathogenic fungus Conidiobolus coronatus (Entomopthorales), disorganize development of Galleria mellonella (Lepidoptera) and affect serotonin-regulating enzymes.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Animals; Carbolines; Conidiobolus; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Developmental; Harmine; Insect Proteins; Larva; Monoamine Oxidase; Moths; Serotonin; Solid Phase Extraction

2018
Cooking with elaborate recipes can reduce the formation of mutagenic heterocyclic amines and promote co-mutagenic amines.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2019, Volume: 36, Issue:3

    Topics: Amines; Animals; Carbolines; Cattle; Cooking; Food Contamination; Harmine; Heterocyclic Compounds; Mutagens; Red Meat

2019
The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:10

    Topics: Adult; Amines; Animals; Carbolines; Feces; Female; Food Contamination; Gastrointestinal Microbiome; Glyceraldehyde; Harmine; Heterocyclic Compounds, Fused-Ring; Humans; Male; Microsomes, Liver; Middle Aged; Propane; Quinolines; Quinoxalines; Rats, Wistar

2019
Use of liquid chromatography quadrupole time-of-flight mass spectrometry and metabolomic approach to discriminate coffee brewed by different methods.
    Food chemistry, 2019, Jul-15, Volume: 286

    Topics: Biomarkers; Carbolines; Chromatography, High Pressure Liquid; Cluster Analysis; Coffee; Cooking; Food Analysis; Harmine; Mass Spectrometry; Metabolomics; Principal Component Analysis

2019
    Food additives & contaminants. Part B, Surveillance, 2020, Volume: 13, Issue:3

    Topics: Arachis; Brassica napus; Carbolines; China; Chromatography, High Pressure Liquid; Cooking; Diet; Flax; Food Contamination; Harmine; Helianthus; Hot Temperature; Humans; Mutagens; Plant Oils; Seeds; Tandem Mass Spectrometry

2020
Simultaneous generation of acrylamide, β-carboline heterocyclic amines and advanced glycation ends products in an aqueous Maillard reaction model system.
    Food chemistry, 2020, Dec-01, Volume: 332

    Topics: Acrylamide; Amines; Asparagine; Carbolines; Chromatography, Gas; Chromatography, High Pressure Liquid; Glucose; Glycation End Products, Advanced; Harmine; Hot Temperature; Lysine; Maillard Reaction; Models, Biological; Pyruvaldehyde

2020
β-Carbolines in Experiments on Laboratory Animals.
    International journal of molecular sciences, 2020, Jul-24, Volume: 21, Issue:15

    Topics: Animals; Brain; Carbolines; Cichorium intybus; Coffee; Gene Expression Regulation; Harmine; Male; Neurodegenerative Diseases; Rats; Rats, Sprague-Dawley

2020
β-Carbolines found in cigarette smoke elevate intracranial self-stimulation thresholds in rats.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 198

    Topics: Animals; Behavior, Addictive; Brain; Carbolines; Female; Harmine; Male; Monoamine Oxidase Inhibitors; Motor Activity; Nicotiana; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Stimulation; Smoke

2020
Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 207

    Topics: Alkaloids; Anabasine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Carbolines; Cotinine; Disease Models, Animal; Female; Harmine; Humans; Male; Nicotine; Pyridines; Solanaceae; Zebrafish

2021
The effect of onion and garlic on non-polar heterocyclic aromatic amines (α-, β-, γ- and δ-carbolines) formation in pan-fried meat and gravy.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2022, Volume: 39, Issue:1

    Topics: Amines; Animals; Antioxidants; Carbolines; Carcinogens; Chromatography, High Pressure Liquid; Garlic; Harmine; Hot Temperature; Humans; Meat; Meat Products; Mutagens; Onions; Swine

2022
Degradation of β-Carbolines Harman and Norharman in Edible Oils during Heating.
    Molecules (Basel, Switzerland), 2021, Nov-20, Volume: 26, Issue:22

    Topics: Alkaloids; Carbolines; Harmine; Heating; Oxidation-Reduction; Plant Oils

2021
Nitrovinylindoles as Heterotrienes: Electrocyclic Cyclization En Route to β-Carbolines: Total Synthesis of Alkaloids Norharmane, Harmane, and Eudistomin N.
    Organic letters, 2022, 10-07, Volume: 24, Issue:39

    Topics: Alkaloids; Biological Products; Carbolines; Cyclization; Harmine

2022