norharman has been researched along with harman in 110 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 18 (16.36) | 18.7374 |
1990's | 31 (28.18) | 18.2507 |
2000's | 26 (23.64) | 29.6817 |
2010's | 24 (21.82) | 24.3611 |
2020's | 11 (10.00) | 2.80 |
Authors | Studies |
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Allen, MS; Codding, PW; Hagen, TJ; Koehler, KF; Martin, MJ; Narayanan, K; Schindler, LR; Schultz, C; Tan, YC; Trudell, ML | 1 |
Barker, SA; Cain, M; Cook, JM; Crawley, JN; Guzman, F; Paul, SM; Rice, KC; Skolnick, P; Weber, RW | 1 |
Good, AC; Peterson, SJ; Richards, WG | 1 |
Platt, DE; Silverman, BD | 1 |
Karplus, M; So, SS | 1 |
Cosentino, ML; Hu, CQ; Ishida, J; Lee, KH; Oyama, M; Wang, HK | 1 |
Deng, Y; Duan, J; Kesuma, D; Qi, RZ; Sim, MM; Song, Y; Teng, SF; Wang, J; Wang, JH | 1 |
Fan, B; Ma, W; Xia, B; Zhang, X; Zheng, B | 1 |
Ahmad, K; Beg, Y; Cho, SJ; Muddassar, M; Pasha, FA | 1 |
Amado, Mdel R; Carrillo, AK; Galarreta, BC; Maruenda, H; Sanchez, L; Sifuentes, R | 1 |
Jiang, X; Liu, J; Peng, L; Peng, S; Zhang, X; Zhao, M; Zheng, M | 1 |
Li, C; Liu, J; Peng, S; Wang, Y; Wu, J; Zhang, X; Zhao, M; Zheng, M | 1 |
Gooyit, M; Janda, KD; Javor, S; Lustigman, S; Tricoche, N | 1 |
Cai, A; Cho, B; Giulietti, JM; Mulcahy, SP; Tate, PM | 1 |
Aaghaz, S; Jain, R; Kamal, A; Sharma, K | 1 |
Dai, JK; Dan, WJ; Wan, JB | 1 |
Chen, C; Chen, D; Chen, X; Dong, X; Gu, R; Han, F; Li, F; Li, Y; Wang, G; Wang, L; Zhang, Y | 1 |
Matsushima, T; Shirai, A; Sugimura, T; Umezawa, K | 1 |
Hayashi, K; Nagao, M; Sugimura, T | 1 |
Legraverend, C; Levitt, RC; Nebert, DW; Pelkonen, O | 1 |
Castellazzi, M; Chang, CC; Glover, TW; Trosko, JE | 1 |
Lin, DX | 1 |
Asakawa, E; Hagiwara, A; Hasegawa, R; Ito, N; Sano, M; Tanaka, H | 1 |
Bourke, CA; Carrigan, MJ; Stevens, GR | 1 |
Asakawa, E; Hagiwara, A; Hirose, M; Ito, N; Kurata, Y; Sano, M | 1 |
May, T; Rommelspacher, H; Schmidt, LG | 1 |
Adachi, J; Fujiwara, S; Mizoi, Y; Naito, T; Ninomiya, I; Yamamoto, K | 1 |
Hagiwara, A; Ito, N; Kato, T; Kurata, Y; Tanaka, H; Tsuda, H | 1 |
Bourke, CA; Carrigan, MJ; Dixon, RJ | 1 |
Lakdawalla, AA; Netrawali, MS | 1 |
Nagao, M; Ohgaki, H; Sugimura, T; Wakabayashi, K; Yamashita, K | 1 |
Bosin, TR; Faull, KF | 1 |
Nakamura, S; Oda, Y; Oki, I | 1 |
Aune, T; Holme, JA; Søderlund, E | 1 |
Barnes, WS; Horn, CL; Weisburger, JH | 1 |
Hayashi, K | 1 |
Oikawa, A; Sugawara, R; Tada, M; Tohda, H | 1 |
Nakasato, F; Nakayasu, M; Sakamoto, H; Sugimura, T; Terada, M | 1 |
Oderfeld-Nowak, B; Rommelspacher, H; Skup, M | 1 |
Dudai, Y; Sherman-Gold, R | 1 |
Keller, H; Riebe, M; Westphal, K | 1 |
Hansen, J; Madle, E; Obe, G; Ristow, H | 1 |
Berger, G; Blum, S; Conrad, C; Hannemann, L; Marks, C; Müller, C; Rommelspacher, H; Schnapper, C; Specht, M; Spies, CD | 1 |
de Meester, C | 1 |
Kühn-Velten, WN | 1 |
May, T; Rommelspacher, H; Salewski, B | 1 |
Greube, A; Heineke, D; Lehmann, J; May, T; Rommelspacher, H; Strauss, S | 1 |
Dammann, G; Ladewig, D; Rommelspacher, H; Stohler, R | 1 |
Funayama, Y; Hasegawa, S; Nagao, M; Nishio, K; Ohira, T; Saijo, N; Shimoi, K; Wakabayashi, K | 1 |
Dufeu, P; Rommelspacher, H; Schmidt, LG | 1 |
Galceran, MT; Moyano, E; Pais, P; Puignou, L | 1 |
Lesch, OM; Walter, H | 1 |
Böning, J; Riederer, P; Rommelspacher, H; Wiesbeck, GA; Wodarz, N | 1 |
Grosse, H; Kuhn, W; Müller, T; Rommelspacher, H | 2 |
Baum, SS; Hill, R; Rommelspacher, H | 1 |
Neuhaus, P; Neuhaus, R; Platzgummer, W; Rommelspacher, H; Schmidt, LG; Wiest, M | 1 |
Damm, H; Klinker, JF; Rommelspacher, H; Seifert, R | 1 |
Arvidsson, P; Jägerstad, M; Skog, K; Solyakov, A | 1 |
Sugimura, T | 1 |
Goto, S; Ishihara, J; Sinha, R; Sugimura, T; Totsuka, Y; Ushiyama, H; Wakabayashi, K | 1 |
Fukazawa, H; Nakano, K; Shiozawa, T; Suyama, K; Terao, Y; Uchida, M; Wakabayashi, K | 1 |
Herraiz, T | 3 |
Pineda, J; Ruiz-Durántez, E; Ugedo, L | 1 |
Diem, S; Gutsche, B; Herderich, M | 1 |
Kloft, C; Meier-Henco, M; Rommelspacher, H; Smolka, M | 1 |
Galisteo, J; Herraiz, T | 2 |
Pfau, W; Skog, K | 1 |
Asamoto, M; Hirose, M; Ichihara, T; Imaida, K; Kawabe, M; Miyashita, K; Ogiso, T; Shirai, T; Tamano, S | 1 |
Bianchi, F; Careri, M; Corradini, C; Elviri, L; Mangia, A; Zagnoni, I | 1 |
Chait, A; de Beaurepaire, R; Molimard, R; Rat, P; Touiki, K | 1 |
Chaparro, C; Herraiz, T | 1 |
Farzin, D; Mansouri, N | 1 |
Alves, RC; Casal, S; Oliveira, BP | 1 |
del Castillo, B; León, AG; Martín, MA; Olives, AI | 1 |
Jin, CM; Lee, JJ; Lee, MK; Lim, SC; Yang, YJ | 1 |
Gibis, M; Jautz, U; Morlock, GE | 1 |
Erra-Balsells, R; Nonami, H; Tarzi, OI | 1 |
Arán, VJ; Guillén, H; Herraiz, T | 1 |
Chen, X; Cromer, BA; Lynch, JW | 1 |
Crotti, AE; Gates, PJ; Lopes, JL; Lopes, NP | 1 |
Arib, O; Chait, A; de Beaurepaire, R; Faure, P; Molimard, R; Rat, P | 1 |
Dixon Clarke, SE; Ramsay, RR | 1 |
Baryar, F; Farzin, D; Haghparast, A; Mansouri, N; Motaman, S | 1 |
Castañeda, G; De Andrés, F; Ríos, A; Sánchez-Rojas, JL; Zougagh, M | 1 |
Liao, GZ; Wang, GY; Xu, XL; Zhang, YJ; Zhou, GH | 1 |
Alam, SM; Alothman, ZA; Lee, SH; Siddiqui, MR; Wabaidur, SM | 1 |
Gibis, M; Weiss, J | 1 |
Domonkos, C; Fitos, I; Visy, J; Zsila, F | 1 |
Abu Ghazaleh, H; Hudson, AL; Lalies, MD; Nutt, DJ | 1 |
Mildner-Szkudlarz, S; Przygoński, K; Wojtowicz, E; Zawirska-Wojtasiak, R | 1 |
Alarifi, A; Chetna, J; Kamal, A; Manasa, KL; Sathish, M; Srinivasulu, V; Tangella, Y | 1 |
Agim, ZS; Cannon, JR; Cruz-Hernandez, A; McCabe, GP; Montenegro, PC; Rochet, JC | 1 |
Jain, RB | 1 |
Boguś, MI; Kaczmarek, A; Kazek, M; Wrońska, AK | 1 |
Busquets, R; Khan, MR; Naushad, M; Puignou, L | 1 |
Beer, F; Bunzel, D; Bunzel, M; Franz, CMAP; Huch, M; Kulling, SE; Urbat, F | 1 |
Chen, A; Chen, F; Lao, F; Liao, X; Wang, X; Xu, L; Xu, Z; Yang, S | 1 |
Mildner-Szkudlarz, S; Piechowska, P; Zawirska-Wojtasiak, R | 1 |
Ma, YX; Wang, XD; Xi, J; Zhang, CX; Zhao, TP | 1 |
Chen, J; He, Z; Jiao, Y; Li, Y; Liu, G; Qin, F; Quan, W; Wang, Z; Xue, C; Zeng, M | 1 |
Bajerska, J; Fedoruk-Wyszomirska, A; Gurda, D; Kubicka, W; Mildner-Szkudlarz, S; Piechowska, P; Przygoński, K; Wojtowicz, E; Wyszko, E; Zawirska-Wojtasiak, R | 1 |
Harris, AC; LeSage, MG; Muelken, P | 1 |
Hawkey, AB; Hoeng, J; Koshibu, K; Levin, ED; Peitsch, MC | 1 |
Janoszka, B; Nowak, A; Śnieżek, E; Szumska, M | 1 |
Cui, Z; Li, Y; Liu, W; Shi, L; Yang, Z | 1 |
Aksenov, AV; Aksenov, DA; Aksenov, NA; Aksenova, IV; Aleksandrova, EV; Arutiunov, NA; Rubin, M | 1 |
8 review(s) available for norharman and harman
Article | Year |
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β-Carbolines as potential anticancer agents.
Topics: Antineoplastic Agents; Carbolines; Cyclin-Dependent Kinases; DNA Topoisomerases; Humans; Intercalating Agents; Neoplasms; Plants; Proto-Oncogene Proteins B-raf; Tubulin | 2021 |
Natural and synthetic β-carboline as a privileged antifungal scaffolds.
Topics: Animals; Antifungal Agents; Biological Products; Carbolines; Drug Discovery; Female; Humans; Male; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycoses; Protein Binding; Signal Transduction; Structure-Activity Relationship | 2022 |
Possible genotoxic carcinogens in foods in relation to cancer causation.
Topics: Animals; Breast Neoplasms; Carbolines; Carcinogens, Environmental; Cattle; Colonic Neoplasms; Cooking; Food; Harmine; Head and Neck Neoplasms; Humans; Imidazoles; Male; Meat; Mutagens; Neoplasms; Nitrates; Nitrites; Nitrosamines; Prostatic Neoplasms | 1983 |
Genotoxic potential of beta-carbolines: a review.
Topics: Animals; Carbolines; DNA; Drug Interactions; Harmine; Humans; Mutagenicity Tests; Mutagens | 1995 |
New 'state' markers for the detection of alcoholism.
Topics: Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Biomarkers; Carbolines; Erythrocyte Indices; Harmine; Humans; Sensitivity and Specificity; Transferrin | 1996 |
Exposure to beta-carbolines norharman and harman.
Topics: Biological Availability; Biomarkers; Carbolines; Harmine; Humans | 2004 |
Dietary inhibitors of monoamine oxidase A.
Topics: Animals; Anxiety Disorders; Carbolines; Depressive Disorder; Harmine; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quercetin; Serotonin | 2011 |
Bioactive β-Carbolines in Food: A Review.
Topics: Animals; Brain; Brain Chemistry; Carbolines; Essential Tremor; Food; Food Handling; Harmine; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Plant Extracts | 2019 |
1 trial(s) available for norharman and harman
Article | Year |
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The levels of norharman are high enough after smoking to affect monoamineoxidase B in platelets.
Topics: Adult; Blood Platelets; Carbolines; Harmine; Humans; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Smoking; Time Factors | 2002 |
101 other study(ies) available for norharman and harman
Article | Year |
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Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site.
Topics: Binding Sites; Carbolines; Chemical Phenomena; Chemistry; Computer Simulation; Ligands; Models, Chemical; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship | 1990 |
Beta-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Carbolines; Chemical Phenomena; Chemistry; Diazepam; Drug Interactions; Indoles; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
Topics: Carbolines; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Imidazoles; Indoles; Molecular Structure; Pyridines; Structure-Activity Relationship | 1993 |
Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.
Topics: Adrenal Cortex Hormones; Binding Sites; Mathematics; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Predictive Value of Tests; Steroids; Structure-Activity Relationship; Testosterone | 1996 |
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
Topics: Cholinesterase Inhibitors; Dopamine beta-Hydroxylase; Drug Design; Enzyme Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Conformation; Molecular Structure; Neural Networks, Computer; Phosphorylases; Receptors, Aryl Hydrocarbon; Static Electricity; Structure-Activity Relationship | 1997 |
Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Furans; Harmine; Humans; Lignans; Lymphocytes; Molecular Structure; Plants, Medicinal; Structure-Activity Relationship | 2001 |
Beta-carbolines as specific inhibitors of cyclin-dependent kinases.
Topics: Carbolines; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Protein Serine-Threonine Kinases | 2002 |
Quantitative structure-activity relationship studies of a series of non-benzodiazepine structural ligands binding to benzodiazepine receptor.
Topics: Ligands; Quantitative Structure-Activity Relationship; Receptors, GABA-A | 2008 |
3D and quantum QSAR of non-benzodiazepine compounds.
Topics: Benzodiazepines; Carbolines; Imaging, Three-Dimensional; Imidazoles; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Pyrimidines; Quantitative Structure-Activity Relationship; Software | 2008 |
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.
Topics: Animals; Biological Products; Enzyme Inhibitors; Flavins; Harmaline; Indole Alkaloids; Leishmania; NADH, NADPH Oxidoreductases; Quinolines; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency.
Topics: Amino Acids; Animals; Carbolines; Fibrinolytic Agents; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Swine | 2010 |
A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.
Topics: Animals; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Drug Design; Fibrinolytic Agents; Hydrazines; Male; Models, Molecular; Molecular Conformation; Platelet Aggregation; Platelet Aggregation Inhibitors; Quantitative Structure-Activity Relationship; Rats; Swine; Thrombosis | 2011 |
Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting.
Topics: | 2015 |
DNA-binding studies of the natural β-carboline eudistomin U.
Topics: Calorimetry, Differential Scanning; Carbolines; Circular Dichroism; DNA; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 2016 |
Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.
Topics: Animals; Antidepressive Agents; Carbolines; Enzyme Inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Tryptophan Oxygenase | 2022 |
Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives.
Topics: 2-Acetylaminofluorene; Alkaloids; Carbolines; Drug Synergism; Fluorenes; Harmine; Microsomes, Liver; Mutagens; Salmonella typhimurium | 1978 |
Interactions of norharman and harman with DNA.
Topics: Alkaloids; Binding Sites; Carbolines; Coliphages; DNA; DNA, Circular; DNA, Superhelical; DNA, Viral; Harmine; Nucleic Acid Conformation; Spectrometry, Fluorescence; Spectrum Analysis | 1977 |
Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture.
Topics: Alkaloids; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Carbolines; Cells, Cultured; DNA; Enzyme Induction; Harmine; Liver; Mutagens | 1977 |
Effects of harman and norharman on spontaneous and ultraviolet light-induced mutagenesis in cultured Chinese hamster cells.
Topics: Alkaloids; Carbolines; Cell Survival; Cells, Cultured; DNA Repair; Harmine; Mutation; Tryptophan; Ultraviolet Rays | 1978 |
[Effects of harman and norharman on aflatoxin B1 and aminopyrine metabolism by phenobarbital and 3-methylcholanthrene-induced rat liver microsomes].
Topics: Aflatoxin B1; Aminopyrine N-Demethylase; Animals; Carbolines; Harmine; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar | 1992 |
Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Carbolines; Carcinogens; Carcinoma, Renal Cell; Diethylnitrosamine; Harmine; Kidney Neoplasms; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1992 |
Locomotor effects in sheep of alkaloids identified in Australian Tribulus terrestris.
Topics: Animals; Carbolines; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Female; Harmine; Locomotion; Plant Extracts; Plant Poisoning; Plants, Edible; Sheep; Sheep Diseases; Spectrophotometry, Ultraviolet | 1992 |
Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats.
Topics: Acetylglucosamine; Animals; Bromodeoxyuridine; Carbolines; DNA; Drinking; Harmine; Kidney Diseases; Kidney Tubules; L-Lactate Dehydrogenase; Male; Microvilli; Organ Size; Phagocytosis; Rats; Rats, Inbred F344; Urination | 1992 |
Plasma norharman (beta-carboline) levels are elevated in chronic alcoholics.
Topics: Adolescent; Adult; Alcoholism; Carbolines; Chromatography, High Pressure Liquid; Ethanol; Female; Follow-Up Studies; Harmine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Psychopathology; Substance Withdrawal Syndrome | 1991 |
Determination of beta-carbolines in foodstuffs by high-performance liquid chromatography and high-performance liquid chromatography-mass spectrometry.
Topics: Acetaldehyde; Alcoholic Beverages; Carbolines; Chromatography, High Pressure Liquid; Ethanol; Food Analysis; Harmine; Ions; Mass Spectrometry | 1991 |
Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman.
Topics: Alkaloids; Animals; Body Weight; Carbolines; Cocarcinogenesis; Diethylnitrosamine; Glutathione Transferase; Harmine; Liver; Male; Rats; Rats, Inbred F344 | 1990 |
Upper motor neurone effects in sheep of some beta-carboline alkaloids identified in zygophyllaceous plants.
Topics: Alkaloids; Animals; Carbolines; Female; Harmaline; Harmine; Locomotion; Motor Neurons; Plants, Toxic; Sheep | 1990 |
Mutagenicity, comutagenicity, and antimutagenicity of erythrosine (FD and C red 3), a food dye, in the Ames/Salmonella assay.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azides; Benzo(a)pyrene; Carbolines; Cecum; DNA Damage; DNA Repair; Drug Interactions; Erythrosine; Ethidium; Fluoresceins; Food Coloring Agents; Harmine; Male; Methyl Methanesulfonate; Microsomes, Liver; Mitomycin; Mitomycins; Mutation; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium Azide | 1988 |
DNA adducts formed by the comutagens harman and norharman in various tissues of mice.
Topics: Alkaloids; Animals; Carbolines; DNA; DNA Damage; Gastric Mucosa; Harmine; Intestine, Large; Kidney; Liver; Mice; Tissue Distribution | 1988 |
Measurement of beta-carbolines by high-performance liquid chromatography with fluorescence detection.
Topics: Animals; Carbolines; Chromatography, High Pressure Liquid; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Harmine; Male; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1988 |
Harman and norharman induce SOS responses and frameshift mutations in bacteria.
Topics: Alkaloids; Carbolines; DNA Repair; Harmine; Mutagenicity Tests; Mutagens; Mutation; Salmonella typhimurium; SOS Response, Genetics | 1988 |
Effects of harman and norharman on the metabolism and genotoxicity of 2-acetylaminofluorene in cultured rat hepatocytes.
Topics: 2-Acetylaminofluorene; Alkaloids; Animals; Carbolines; Cells, Cultured; DNA; DNA Repair; Drug Synergism; Harmine; Liver; Male; Mutagens; Rats; Rats, Inbred Strains | 1985 |
[Effects of harman and norharman on the metabolism of aniline and p-dimethylaminoazobenzene (author's transl)].
Topics: Alkaloids; Aniline Compounds; Aniline Hydroxylase; Animals; Carbolines; Harmine; Male; Microsomes, Liver; p-Dimethylaminoazobenzene; Rats | 1981 |
Actions of amino-beta-carbolines on induction of sister-chromatid exchanges.
Topics: Animals; Carbolines; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; Harmine; Indoles; Ovary; Sister Chromatid Exchange; Structure-Activity Relationship | 1983 |
Mutagenic activity of norharman and harman in Chinese hamster lung cells in assays with diphtheria toxin resistance as a marker.
Topics: Alkaloids; Animals; Biotransformation; Carbolines; Cell Line; Cell Survival; Cricetinae; Cricetulus; Diphtheria Toxin; Drug Resistance; Female; Harmine; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Ovary | 1983 |
In vitro studies on the effect of beta-carbolines on the activities of acetylcholinesterase and choline acetyltransferase and on the muscarinic receptor binding of the rat brain.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Carbolines; Cattle; Choline O-Acetyltransferase; Erythrocytes; Harmaline; Harmine; Indoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Structure-Activity Relationship | 1983 |
beta-Carboline binding to deoxycholate solubilized benzodiazepine receptors from calf cerebral cortex.
Topics: Alkaloids; Animals; Benzodiazepines; Carbolines; Cattle; Cerebral Cortex; Deoxycholic Acid; Flunitrazepam; Harmine; Receptors, Drug; Solubility; Statistics as Topic; Tritium | 1981 |
Test-condition-dependent influence of harman and nonharman on benzo[a]pyrene mutagenesis in Salmonella.
Topics: Alkaloids; Animals; Benzopyrenes; Biotransformation; Carbolines; Dose-Response Relationship, Drug; Harmine; In Vitro Techniques; Liver; Mice; Mutagenicity Tests; Mutagens; Rats; Salmonella typhimurium | 1982 |
Harman and norharman: induction of sister-chromatid exchanges in human peripheral lymphocytes in vitro and interaction with isolated DNA.
Topics: Alkaloids; Carbolines; Chromosome Aberrations; Crossing Over, Genetic; DNA; Harmine; Humans; Lymphocytes; Sister Chromatid Exchange; Structure-Activity Relationship; Transcription, Genetic; Triaziquone | 1981 |
Beta-carbolines in chronic alcoholics undergoing elective tumor resection.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Biomarkers; Carbolines; Critical Care; Esophageal Neoplasms; Harmine; Humans; Male; Middle Aged; Otorhinolaryngologic Neoplasms; Postoperative Complications; Risk Factors | 1995 |
Norharman (beta-carboline) as a potent inhibitory ligand for steroidogenic cytochromes P450 (CYP11 and CYP17).
Topics: Adrenal Glands; Animals; Binding, Competitive; Carbolines; Harmine; Male; Microsomes; Mitochondria; Progesterone; Rats; Spectrophotometry, Ultraviolet; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Testis | 1993 |
Harman (1-methyl-beta-carboline) is a natural inhibitor of monoamine oxidase type A in rats.
Topics: Animals; Beer; Binding Sites; Brain; Carbolines; Harmine; Kidney; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocardium; Pargyline; Rats; Rats, Wistar; Tissue Distribution; Wine | 1994 |
Comparison of the in vitro binding characteristics of the beta-carbolines harman and norharman in rat brain and liver and in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Brain; Carbolines; Cattle; Harmine; In Vitro Techniques; Liver; Male; Rats; Rats, Wistar; Subcellular Fractions; Temperature | 1994 |
[Beta-carbolines (harman/norharman) are increased in heroin dependent patients].
Topics: Adult; Carbolines; Female; Harmine; Heroin Dependence; Humans; Male; Methadone; Substance Withdrawal Syndrome | 1993 |
Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities.
Topics: Breast Neoplasms; Carbolines; Carcinoma, Small Cell; Cell Line; Enzyme Inhibitors; Female; Harmine; Humans; Kinetics; Mutagens; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1996 |
Harman and norharman in alcoholism: correlations with psychopathology and long-term changes.
Topics: Adult; Alcoholism; Anxiety; Carbolines; Depression; Ethanol; Harmine; Humans; Male; Middle Aged; Motivation; Self Medication | 1996 |
Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectrometry.
Topics: Amines; Animals; Calibration; Carbolines; Cattle; Chromatography, High Pressure Liquid; Harmine; Heterocyclic Compounds; Mass Spectrometry; Meat; Mutagens | 1996 |
Excretion of beta-carbolines harman and norharman in 24-hour urine of chronic alcoholics during withdrawal and controlled abstinence.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Biomarkers; Carbolines; Harmine; Humans; Male; Middle Aged; Motivation; Patient Admission; Personality Inventory; Treatment Outcome | 1996 |
Plasma harman and norharman in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Carbolines; Case-Control Studies; Female; Harmine; Humans; Male; Middle Aged; Neurotoxins; Parkinson Disease | 1995 |
Harman-induced changes of extracellular concentrations of neurotransmitters in the nucleus accumbens of rats.
Topics: Animals; Carbolines; Dopamine; Harmine; Male; Microdialysis; Neurotoxins; Nucleus Accumbens; Rats; Rats, Wistar; Serotonin | 1996 |
Long-term changes of markers of alcoholism after orthotopic liver transplantation (OLT).
Topics: Adult; Alcoholism; Analysis of Variance; Carbolines; Harmine; Humans; Liver Diseases, Alcoholic; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Neurotoxins; Time Factors | 1996 |
Elevated levels of harman and norharman in cerebrospinal fluid of parkinsonian patients.
Topics: Adult; Aged; Carbolines; Case-Control Studies; Female; Harmine; Humans; Male; Middle Aged; Neurotoxins; Parkinson Disease | 1996 |
Activation by beta-carbolines of G-proteins in HL-60 membranes and the bovine retinal G-protein transducin in a receptor-independent manner.
Topics: Carbolines; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Harmine; HL-60 Cells; Humans; Intercellular Signaling Peptides and Proteins; Peptides; Structure-Activity Relationship; Transducin; Wasp Venoms | 1997 |
Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectrometry.
Topics: Amines; Animals; Carbolines; Carcinogens; Cooking; Gas Chromatography-Mass Spectrometry; Harmine; Heterocyclic Compounds; Hot Temperature; Meat; Meat Products; Mutagens; Reindeer; Surface Properties; Swine | 1998 |
A new concept of co-mutagenicity from a phenomenon forgotten for the past two decades: is it more important than previously expected?
Topics: Animals; Carbolines; Drug Synergism; Harmine; Mutagenicity Tests; Mutagens; Salmonella typhimurium | 1998 |
Quantification of the co-mutagenic beta-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods.
Topics: Carbolines; Food; Harmine; Humans; Mutagens; Tobacco Smoke Pollution | 1999 |
Chlorination of harman and norharman with sodium hypochlorite and co-mutagenicity of the chlorinated products.
Topics: Biotransformation; Carbolines; Harmine; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Sodium Hypochlorite | 2000 |
Tetrahydro-beta-carboline-3-carboxylic acid compounds in fish and meat: possible precursors of co-mutagenic beta-carbolines norharman and harman in cooked foods.
Topics: Animals; Carbolines; Cattle; Chromatography, High Pressure Liquid; Food Handling; Food Preservation; Harmine; Meat; Mutagens; Seafood; Swine | 2000 |
Stimulatory effect of harmane and other beta-carbolines on locus coeruleus neurons in anaesthetized rats.
Topics: Anesthesia; Animals; Carbolines; Electrophysiology; Harmaline; Harmine; Imidazoline Receptors; Locus Coeruleus; Male; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Vagotomy | 2001 |
Degradation of tetrahydro-beta-carbolines in the presence of nitrite: HPLC-MS analysis of the reaction products.
Topics: Carbolines; Chromatography, High Pressure Liquid; Food Analysis; Harmine; Kinetics; Mass Spectrometry; Molecular Conformation; Nitrites | 2001 |
Identification and occurrence of the bioactive beta-carbolines norharman and harman in coffee brews.
Topics: Alkaloids; Carbolines; Chromatography, High Pressure Liquid; Coffee; Food Contamination; Harmine; Mass Spectrometry | 2002 |
Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay.
Topics: Antioxidants; Benzothiazoles; Carbolines; Cations; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Food Analysis; Free Radicals; Gas Chromatography-Mass Spectrometry; Harmine; Indicators and Reagents; Models, Chemical; Sulfonic Acids; Time Factors | 2002 |
Relative exposure to beta-carbolines norharman and harman from foods and tobacco smoke.
Topics: Carbolines; Chromatography, High Pressure Liquid; Environmental Exposure; Food Analysis; Food Contamination; Food Handling; Harmine; Mutagens; Neurotoxins; Nicotiana; Smoke | 2004 |
Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.
Topics: Amitrole; Animals; Carbolines; Harmine; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Sodium Nitrite; Weight Gain | 2005 |
Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.
Topics: Acetonitriles; Amines; Buffers; Carbolines; Chromatography, Liquid; Formates; Harmine; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; Quinolines; Quinoxalines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Harmane inhibits serotonergic dorsal raphe neurons in the rat.
Topics: Action Potentials; Analysis of Variance; Animals; Carbolines; Citalopram; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Harmine; Male; Neurons; Neurotoxins; Nicotine; Nicotinic Agonists; Oxazoles; Phenethylamines; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin; Serotonin Antagonists | 2005 |
Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee.
Topics: Carbolines; Chromatography, High Pressure Liquid; Coffee; Harmine; Humans; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization | 2006 |
Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; GABA Modulators; Harmine; Male; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Reserpine; Swimming; Sympatholytics | 2006 |
Factors influencing the norharman and harman contents in espresso coffee.
Topics: Carbolines; Coffea; Coffee; Food Handling; Harmine; Hot Temperature; Mutagens; Neurotoxins; Pressure; Seeds; Species Specificity; Time Factors | 2007 |
Influence of the presence of methyl cyclodextrins in high-performance liquid chromatography mobile phases on the separation of beta-carboline alkaloids.
Topics: beta-Cyclodextrins; Carbolines; Chromatography, High Pressure Liquid; Harmine; Indicators and Reagents; Reference Standards; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2008 |
Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.
Topics: Animals; Antiparkinson Agents; Apoptosis; Aromatic-L-Amino-Acid Decarboxylases; Blotting, Northern; Calcium; Carbolines; Cell Survival; Cyclic AMP; Dopamine; Flow Cytometry; Harmine; In Situ Nick-End Labeling; Levodopa; Membrane Potentials; Mitochondrial Membranes; PC12 Cells; Rats; RNA; Tetrazolium Salts; Thiazoles; Tyrosine 3-Monooxygenase | 2008 |
Quantification of heterocyclic aromatic amines in fried meat by HPTLC/UV-FLD and HPLC/UV-FLD: a comparison of two methods.
Topics: Amines; Animals; Carbolines; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Harmine; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat; Mutagens; Quinoxalines | 2008 |
The effect of temperature on the stability of compounds used as UV-MALDI-MS matrix: 2,5-dihydroxybenzoic acid, 2,4,6-trihydroxyacetophenone, alpha-cyano-4-hydroxycinnamic acid, 3,5-dimethoxy-4-hydroxycinnamic acid, nor-harmane and harmane.
Topics: Acetophenones; Carbolines; Coumaric Acids; Gentisates; Harmine; Hot Temperature; Magnetic Resonance Spectroscopy; Phase Transition; Photochemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |
Oxidative metabolism of the bioactive and naturally occurring beta-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes.
Topics: Carbolines; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Harmine; Humans; Hydroxylation; Microsomes, Liver; Oxidation-Reduction | 2008 |
Molecular determinants of beta-carboline inhibition of the glycine receptor.
Topics: Binding Sites; Carbolines; Cell Line; Harmine; Humans; Mutagenesis, Site-Directed; Mutation; Protein Structure, Secondary; Protein Subunits; Receptors, Glycine; Recombinant Proteins | 2009 |
Electrospray MS-based characterization of beta-carbolines--mutagenic constituents of thermally processed meat.
Topics: Carbolines; Food Analysis; Food Handling; Food Technology; Harmine; Hot Temperature; Meat; Mutagens; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Water | 2010 |
Electrophysiological characterization of harmane-induced activation of mesolimbic dopamine neurons.
Topics: Animals; Carbolines; Dopamine; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Harmine; Male; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2010 |
Effects of harmane and other β-carbolines on apomorphine-induced licking behavior in rat.
Topics: Animals; Apomorphine; Carbolines; Corpus Striatum; Dopamine Agonists; Drug Interactions; Flumazenil; Harmine; Male; Rats; Rats, Wistar; Receptors, GABA-A; Reserpine; Stereotyped Behavior | 2011 |
Screening of non-polar heterocyclic amines in urine by microextraction in packed sorbent-fluorimetric detection and confirmation by capillary liquid chromatography.
Topics: Carbolines; Chromatography, Liquid; Fluorescence; Harmine; Heterocyclic Compounds; Humans; Molecular Structure; Time Factors | 2011 |
Formation of heterocyclic amines during cooking of duck meat.
Topics: Amines; Animals; Carbolines; China; Chromatography, High Pressure Liquid; Cooking; Ducks; Food Contamination; Harmine; Heterocyclic Compounds; Hot Temperature; Imidazoles; Maillard Reaction; Meat; Microwaves; Mutagens; Quinolines; Quinoxalines; Solid Phase Extraction; Time Factors | 2012 |
Second derivative synchronous fluorimetric method for simultaneous determination of harman and norharman in coffee samples.
Topics: Carbolines; Coffee; Harmine; Limit of Detection; Neurotoxins; Spectrometry, Fluorescence | 2013 |
Formation of heterocyclic amines in salami and ham pizza toppings during baking of frozen pizza.
Topics: Amines; Animals; Carbolines; Chromatography, High Pressure Liquid; Color; Consumer Behavior; Cooking; Freezing; Harmine; Hot Temperature; Humans; Imidazoles; Maillard Reaction; Meat Products; Quinoxalines; Swine; Taste | 2013 |
Fatty acid modulated human serum albumin binding of the β-carboline alkaloids norharmane and harmane.
Topics: Alkaloids; Binding Sites; Carbolines; Fatty Acids; Harmine; Humans; Hydrogen-Ion Concentration; Ligands; Protein Binding; Serum Albumin | 2013 |
Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases.
Topics: Ascorbic Acid; Carbolines; Enzyme Inhibitors; Harmine; Heme; Horseradish Peroxidase; Hydroxylamine; Kinetics; Lactoperoxidase; Oxidation-Reduction; Peroxidase; Peroxidases; Sodium Azide; Tryptophan | 2014 |
The modulatory action of harmane on serotonergic neurotransmission in rat brain.
Topics: Animals; Calcium; Calcium Chelating Agents; Carbolines; Cerebral Cortex; Dopamine; Dose-Response Relationship, Drug; Egtazic Acid; Harmine; Ions; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Pargyline; Potassium; Rats, Wistar; Serotonin; Serotonin Agents; Synaptic Transmission; Tissue Culture Techniques | 2015 |
Bioactive β-carbolines norharman and harman in traditional and novel raw materials for chicory coffee.
Topics: Beverages; Carbolines; Cichorium intybus; Coffee; Harmine; Hot Temperature | 2015 |
PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I.
Topics: Acetates; Carbolines; Decarboxylation; Harmine; Iodobenzenes; Molecular Structure; Oxidation-Reduction | 2015 |
Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons.
Topics: Amines; Animals; Carbolines; Dopaminergic Neurons; Dose-Response Relationship, Drug; Harmine; Heterocyclic Compounds, 3-Ring; Mesencephalon; Molecular Structure; Nerve Degeneration; Neurites; Neurons; Primary Cell Culture; Quinolines; Quinoxalines; Rats | 2018 |
Concentrations of selected heterocyclic aromatic amines among US population aged ≥ 6 years: data from NHANES 2013-2014.
Topics: Adolescent; Adult; Aged; Air Pollution, Indoor; Carbolines; Child; Environmental Exposure; Female; Harmine; Humans; Imidazoles; Male; Middle Aged; Nutrition Surveys; Racial Groups; Tobacco Smoke Pollution; United States; Young Adult | 2018 |
Harman and norharman, metabolites of entomopathogenic fungus Conidiobolus coronatus (Entomopthorales), disorganize development of Galleria mellonella (Lepidoptera) and affect serotonin-regulating enzymes.
Topics: Animals; Carbolines; Conidiobolus; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Developmental; Harmine; Insect Proteins; Larva; Monoamine Oxidase; Moths; Serotonin; Solid Phase Extraction | 2018 |
Cooking with elaborate recipes can reduce the formation of mutagenic heterocyclic amines and promote co-mutagenic amines.
Topics: Amines; Animals; Carbolines; Cattle; Cooking; Food Contamination; Harmine; Heterocyclic Compounds; Mutagens; Red Meat | 2019 |
The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations.
Topics: Adult; Amines; Animals; Carbolines; Feces; Female; Food Contamination; Gastrointestinal Microbiome; Glyceraldehyde; Harmine; Heterocyclic Compounds, Fused-Ring; Humans; Male; Microsomes, Liver; Middle Aged; Propane; Quinolines; Quinoxalines; Rats, Wistar | 2019 |
Use of liquid chromatography quadrupole time-of-flight mass spectrometry and metabolomic approach to discriminate coffee brewed by different methods.
Topics: Biomarkers; Carbolines; Chromatography, High Pressure Liquid; Cluster Analysis; Coffee; Cooking; Food Analysis; Harmine; Mass Spectrometry; Metabolomics; Principal Component Analysis | 2019 |
Topics: Arachis; Brassica napus; Carbolines; China; Chromatography, High Pressure Liquid; Cooking; Diet; Flax; Food Contamination; Harmine; Helianthus; Hot Temperature; Humans; Mutagens; Plant Oils; Seeds; Tandem Mass Spectrometry | 2020 |
Simultaneous generation of acrylamide, β-carboline heterocyclic amines and advanced glycation ends products in an aqueous Maillard reaction model system.
Topics: Acrylamide; Amines; Asparagine; Carbolines; Chromatography, Gas; Chromatography, High Pressure Liquid; Glucose; Glycation End Products, Advanced; Harmine; Hot Temperature; Lysine; Maillard Reaction; Models, Biological; Pyruvaldehyde | 2020 |
β-Carbolines in Experiments on Laboratory Animals.
Topics: Animals; Brain; Carbolines; Cichorium intybus; Coffee; Gene Expression Regulation; Harmine; Male; Neurodegenerative Diseases; Rats; Rats, Sprague-Dawley | 2020 |
β-Carbolines found in cigarette smoke elevate intracranial self-stimulation thresholds in rats.
Topics: Animals; Behavior, Addictive; Brain; Carbolines; Female; Harmine; Male; Monoamine Oxidase Inhibitors; Motor Activity; Nicotiana; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Stimulation; Smoke | 2020 |
Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish.
Topics: Alkaloids; Anabasine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Carbolines; Cotinine; Disease Models, Animal; Female; Harmine; Humans; Male; Nicotine; Pyridines; Solanaceae; Zebrafish | 2021 |
The effect of onion and garlic on non-polar heterocyclic aromatic amines (α-, β-, γ- and δ-carbolines) formation in pan-fried meat and gravy.
Topics: Amines; Animals; Antioxidants; Carbolines; Carcinogens; Chromatography, High Pressure Liquid; Garlic; Harmine; Hot Temperature; Humans; Meat; Meat Products; Mutagens; Onions; Swine | 2022 |
Degradation of β-Carbolines Harman and Norharman in Edible Oils during Heating.
Topics: Alkaloids; Carbolines; Harmine; Heating; Oxidation-Reduction; Plant Oils | 2021 |
Nitrovinylindoles as Heterotrienes: Electrocyclic Cyclization En Route to β-Carbolines: Total Synthesis of Alkaloids Norharmane, Harmane, and Eudistomin N.
Topics: Alkaloids; Biological Products; Carbolines; Cyclization; Harmine | 2022 |