norfentanyl has been researched along with noralfentanil* in 1 studies
1 other study(ies) available for norfentanyl and noralfentanil
| Article | Year |
|---|---|
Development of a gas chromatographic-mass spectrometric drug screening method for the N-dealkylated metabolites of fentanyl, sufentanil, and alfentanil.
A sensitive, specific urinary assay for fentanyl, sufentanil, and alfentanil based on their N-dealkylated metabolites is described. Norfentanyl, norsufentanil-noralfentanil, and 2H5-norfentanyl are synthesized and characterized by standard analytical techniques. Derivatization of these secondary amines to yield the pentafluorobenzamides produces stable products with good gas chromatographic properties and unique, high-mass fragments in their mass spectra. These properties are utilized to develop a drug screening procedure based on gas chromatography-mass spectrometry to detect these major metabolites in human urine. The metabolites are isolated from urine samples by a liquid-liquid extraction procedure. The method allows for detection of metabolite concentrations as low as 0.3 ng/mL. Topics: Alfentanil; Analgesics, Opioid; Drug Residues; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Sensitivity and Specificity; Sufentanil | 1997 |