nordazepam and temazepam

nordazepam has been researched along with temazepam in 59 studies

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-199021 (35.59)18.7374
1990's14 (23.73)18.2507
2000's8 (13.56)29.6817
2010's13 (22.03)24.3611
2020's3 (5.08)2.80

Authors

AuthorsStudies
Collins, RJ; Gall, M; Kamdar, BV1
Babbini, M; Barbaro, AM; Bartoletti, M; Biagi, GL; Borea, PA; Gaiardi, M; Guerra, MC1
Johnston, GA; Maddalena, DJ1
Karplus, M; So, SS1
Topliss, JG; Yoshida, F1
Du-Cuny, L; Huwyler, J; Kansy, M; Wiese, M1
Carmona, AV; Kumari, S; Tiwari, AK; Trippier, PC1
Liljequist, R; Linnoila, M; Palva, E1
Baars, AM; Hekster, YA; O'Reilly, WJ; van der Kleijn, E; Vree, TB1
Allen, MD; Greenblatt, DJ; Orsulak, PJ; Shader, RI; Woo, E1
Clarke, CH; Nicholson, AN1
Kanto, J; Mäenpää, M; Mäntylä, R; Sellman, R; Valovirta, E1
Beischlag, TV; Inaba, T; Kalow, W; Mahon, WA1
Guentert, TW; Stebler, T1
Hooper, WD; Mason, SR; Reilly, PE; Thompson, DA1
Dusci, LJ; Good, SM; Hall, RW; Ilett, KF1
Chenery, RJ; Lockwood, GF; Seddon, T1
Klockowski, PM; Levy, G2
Brase, DA; Dewey, WL; Glennon, RA; Young, R1
Dolan, S; Lau, CE; Tang, M1
Igarashi, T; Kitagawa, H; Ohmori, S; Okiyama, M; Ueno, K1
Moroji, T; Motomura, H; Noguchi, T; Sekiguchi, R; Tada, K1
Martin, WR; McNicholas, LF; Pruitt, TA1
Meeles, MT; Thys, CP; Tjaden, UR; van der Kaay, M1
El-Hazmi, MA1
Löscher, W1
Booij, LH; Crul, JF; Driessen, JJ; van Egmond, J; Vree, TB1
Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL1
Bittencourt, PR; Richens, A; Smith, AT; Wade, P1
Chiba, K; Chiba, T; Hirano, T; Horii, H; Ishizaki, T; Kato, Y1
Andersson, T; Birkett, DJ; Miners, JO; Veronese, ME1
Pang, KS; St-Pierre, MV1
Garretty, DJ; Hay, AW; Raistrick, D; Wolff, K1
Gunaratna, C; Kissinger, PT1
Gelboin, HV; Gonzalez, FJ; Korzekwa, KR; Shou, M; Yang, SK; Yang, TJ1
Ali, HM; Azzam, RM; Notarianni, LJ1
Baillie, TA; Dai, R; Ettore, MW; Mei, Q; Rushmore, TH; Shou, M1
Mørland, J; Olsen, KM; Skuterud, B; Smith-Kielland, A1
Contel, N; Grossman, S; Liu, Z; Ren, S; Rose, A; Short, J; Unger, S1
Djeridane, Y; Touitou, Y1
Acikgöz, A; Bader, A; Giri, S; Karim, N; Schmidt-Heck, W1
Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS1
Iannello, C; Mandrioli, R; Matrisciano, F; Mercolini, L; Nicoletti, F; Raggi, MA1
Abe, K; Kobayashi, N; Nakamura, K; Nishiya, Y; Okazaki, O; Okudaira, N1
Allen, KR; Glover, SJ1
Acikgöz, A; Bader, A; Giri, S; Maringka, M; Nieber, K1
Bowron, P; Fu, S; Lewis, J; Molnar, A; Wang, H1
Marin, SJ; McMillin, GA; Roberts, M; Wood, M1
Liang, C; Ni, C; Rao, Y; Wang, R; Wang, X; Xiong, L; Zhang, Y1
Atayee, RS; Best, BM; Luk, S; Ma, JD1
Bertol, E; Boscolo Berto, R; Favretto, D; Mannaioni, G; Mari, F; Vaiano, F1
Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W1
Li, J; Liu, H; Wu, L; Zhang, J1
Darwish, WS; Hayami, A; Ikenaka, Y; Ishizuka, M; Kawai, YK; Mizukawa, H; Nakayama, SM; Watanabe, KP1
Jia, J; Jiang, F; Johansen, SS; Linnet, K; Rao, Y; Wang, X; Zhang, Y1
Castro, A; Costa, P; Franco, JM; Melo, P; Quintas, MJ; Tarelho, S; Teixeira, HM1
Coulter, C; Garnier, M; Moore, C1
Adhikari, S; Barron, LP; Bhatnagar, A; Bowes, DA; Coronado-Apodaca, KG; Driver, EM; Halden, RU; Kumar, R; Martínez-Ruiz, M; McCall, KL; Melchor-Martínez, EM; Ng, KT; Oyervides-Muñoz, MA; Parra-Saldivar, R; Piper, BJ; Smith, T; Sosa-Hernandez, JE1

Reviews

1 review(s) available for nordazepam and temazepam

ArticleYear
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.
    Journal of medicinal chemistry, 2020, 11-12, Volume: 63, Issue:21

    Topics: Amides; Carbamates; Click Chemistry; Drug Design; Pyridines; Structure-Activity Relationship; Triazoles; Urea

2020

Trials

4 trial(s) available for nordazepam and temazepam

ArticleYear
Effects on learning and memory of 2-week treatments with chlordiazepoxide lactam, N-desmethyldiazepam, oxazepam and methyloxazepam, alone or in combination with alcohol.
    International pharmacopsychiatry, 1979, Volume: 14, Issue:4

    Topics: Adult; Anti-Anxiety Agents; Chlordiazepoxide; Drug Interactions; Ethanol; Humans; Learning; Memory; Memory, Short-Term; Nordazepam; Oxazepam; Temazepam; Time Factors

1979
Immediate and residual effects in man of the metabolites of diazepam.
    British journal of clinical pharmacology, 1978, Volume: 6, Issue:4

    Topics: Adult; Choice Behavior; Diazepam; Humans; Male; Motor Skills; Nordazepam; Oxazepam; Placebos; Reaction Time; Temazepam; Time Factors

1978
The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:4

    Topics: Adult; Benzodiazepines; Diazepam; Double-Blind Method; Eye Movements; Flurazepam; Humans; Male; Nitrazepam; Nordazepam; Reticular Formation; Saccades; Temazepam

1981
Urinary excretion of diazepam metabolites in healthy volunteers and drug users.
    Scandinavian journal of clinical and laboratory investigation, 2001, Volume: 61, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Creatinine; Diazepam; Female; Humans; Male; Middle Aged; Nordazepam; Oxazepam; Substance Abuse Detection; Substance-Related Disorders; Temazepam

2001

Other Studies

54 other study(ies) available for nordazepam and temazepam

ArticleYear
Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:12

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Hydroxylation; Male; Methods; Mice; Oxidation-Reduction; Triazolam; Triazoles

1978
Rm values and structure-activity relationship of benzodiazepines.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:2

    Topics: Animals; Benzodiazepines; Chromatography, Thin Layer; Conflict, Psychological; Exploratory Behavior; Models, Biological; Rats; Solubility; Structure-Activity Relationship

1980
Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks.
    Journal of medicinal chemistry, 1995, Feb-17, Volume: 38, Issue:4

    Topics: Binding Sites; Ligands; Neural Networks, Computer; Predictive Value of Tests; Receptors, GABA-A; Structure-Activity Relationship

1995
Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors.
    Journal of medicinal chemistry, 1996, Dec-20, Volume: 39, Issue:26

    Topics: Algorithms; Benzodiazepines; Models, Genetic; Nerve Net; Protein Binding; Receptors, GABA-A; Structure-Activity Relationship

1996
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Computational aqueous solubility prediction for drug-like compounds in congeneric series.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Benzodiazepines; Computer Simulation; Crystallography, X-Ray; Databases, Factual; Least-Squares Analysis; Models, Chemical; Organic Chemicals; Pharmaceutical Preparations; Principal Component Analysis; Solubility; Sulfonamides; Water

2008
Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.
    Journal of chromatography, 1979, Apr-11, Volume: 162, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Dogs; Humans; Nordazepam; Oxazepam; Species Specificity; Temazepam

1979
Rapid recovery from massive diazepam overdose.
    JAMA, 1978, Oct-20, Volume: 240, Issue:17

    Topics: Adult; Biotransformation; Diazepam; Female; Half-Life; Humans; Male; Middle Aged; Nordazepam; Oxazepam; Remission, Spontaneous; Suicide, Attempted; Temazepam; Time Factors

1978
Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia.
    Anesthesiology, 1979, Volume: 51, Issue:2

    Topics: Adult; Age Factors; Aged; Anesthesia, Spinal; Body Water; Diazepam; Humans; Kinetics; Middle Aged; Nordazepam; Oxazepam; Temazepam

1979
Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5

    Topics: Animals; Chromatography, Gas; Diazepam; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Mephenytoin; Methylation; Nordazepam; Polymorphism, Genetic; Rats; Temazepam

1992
Determination of diazepam and nordazepam in milk and plasma in the presence of oxazepam and temazepam.
    Journal of chromatography, 1991, Mar-08, Volume: 564, Issue:1

    Topics: Chromatography, High Pressure Liquid; Diazepam; Flurazepam; Humans; Hydrogen-Ion Concentration; Milk, Human; Nordazepam; Oxazepam; Temazepam

1991
Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam.
    Molecular pharmacology, 1990, Volume: 37, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Cytochrome P-450 Enzyme System; Diazepam; Female; Hydroxylation; Kinetics; Male; Microsomes, Liver; Nordazepam; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Substrate Specificity; Temazepam

1990
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:1

    Topics: Adult; Diazepam; Drug Combinations; Female; Humans; Infant; Milk, Human; Nordazepam; Oxazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Temazepam

1990
In vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days.
    Biochemical pharmacology, 1989, Aug-15, Volume: 38, Issue:16

    Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Diazepam; Liver; Macaca fascicularis; Male; Models, Biological; Nordazepam; Oxazepam; Oxygenases; Temazepam; Time Factors

1989
Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Female; Nordazepam; Oxazepam; Rats; Rats, Inbred Lew; Reflex; Temazepam

1988
Potencies of diazepam metabolites in rats trained to discriminate diazepam.
    Life sciences, 1986, Jul-07, Volume: 39, Issue:1

    Topics: Animals; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Nordazepam; Oxazepam; Rats; Rats, Inbred Strains; Temazepam

1986
Microsample determination of diazepam and its three metabolites in serum by reversed-phase high-performance liquid chromatography.
    Journal of chromatography, 1987, Apr-24, Volume: 416, Issue:1

    Topics: Animals; Biotransformation; Chlordiazepoxide; Chromatography, High Pressure Liquid; Diazepam; Hydrogen-Ion Concentration; Indicators and Reagents; Nordazepam; Rats; Spectrophotometry, Ultraviolet; Temazepam

1987
Simultaneous determination of diazepam and its active metabolites in rat serum, brain and cerebrospinal fluid by high-performance liquid chromatography.
    Journal of chromatography, 1987, Nov-27, Volume: 422

    Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Female; Nordazepam; Oxazepam; Postural Balance; Rats; Rats, Inbred Strains; Temazepam

1987
Imipramine treatment alters the pharmacokinetics and pharmacodynamics of diazepam.
    Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:12

    Topics: Animals; Blood Proteins; Brain Chemistry; Diazepam; Drug Interactions; Imipramine; Liver; Male; Nordazepam; Oxazepam; Pentylenetetrazole; Protein Binding; Rats; Rats, Inbred Strains; Temazepam

1987
Liquid-chromatographic assay of diazepam and its major metabolites in serum, and application to pharmacokinetic study of high doses of diazepam in schizophrenics.
    Clinical chemistry, 1985, Volume: 31, Issue:10

    Topics: Administration, Oral; Chromatography, High Pressure Liquid; Diazepam; Female; Humans; Kinetics; Nordazepam; Oxazepam; Schizophrenia; Temazepam

1985
N-desmethyldiazepam physical dependence in dogs.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Analysis of Variance; Animals; Body Weight; Diazepam; Dogs; Drinking; Energy Intake; Female; Lorazepam; Muscle Spasticity; Nordazepam; Oxazepam; Paresthesia; Substance Withdrawal Syndrome; Temazepam; Time Factors

1985
Determination of some benzodiazepines and metabolites in serum, urine and saliva by high-performance liquid chromatography.
    Journal of chromatography, 1980, Feb-08, Volume: 181, Issue:2

    Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Humans; Mathematics; Nordazepam; Oxazepam; Saliva; Temazepam

1980
Aspects of the interaction of thyroxine and its binding serum proteins with 1,4-benzodiazepine tranquillizers.
    Biochemical medicine, 1981, Volume: 26, Issue:2

    Topics: Anti-Anxiety Agents; Autoradiography; Binding, Competitive; Chlordiazepoxide; Diazepam; Electrophoresis, Polyacrylamide Gel; Humans; Male; Nordazepam; Oxazepam; Temazepam; Thyroxine; Thyroxine-Binding Proteins

1981
Rapid gas chromatographic measurement of diazepam and its metabolites desmethyldiazepam, oxazepam, and 3-hydroxydiazepam (temazepam) in small samples of plasma.
    Therapeutic drug monitoring, 1982, Volume: 4, Issue:3

    Topics: Anti-Anxiety Agents; Biotransformation; Chromatography, Gas; Diazepam; Humans; Nordazepam; Oxazepam; Temazepam

1982
In vitro interaction of diazepam and oxazepam with pancuronium and suxamethonium.
    British journal of anaesthesia, 1984, Volume: 56, Issue:10

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Muscle Contraction; Neuromuscular Junction; Nordazepam; Oxazepam; Pancuronium; Rats; Rats, Inbred Strains; Succinylcholine; Temazepam

1984
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
    Pharmacology and therapeutics in dentistry, 1980, Volume: 5, Issue:1-2

    Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacaine; Mice; Nitrazepam; Nordazepam; Oxazepam; Prilocaine; Seizures; Structure-Activity Relationship; Temazepam

1980
Development and preliminary application of high-performance liquid chromatographic assay of urinary metabolites of diazepam in humans.
    Journal of chromatography. B, Biomedical applications, 1995, Jun-09, Volume: 668, Issue:1

    Topics: Chromatography, High Pressure Liquid; Diazepam; Humans; Nordazepam; Oxazepam; Reference Values; Reproducibility of Results; Temazepam

1995
Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.
    British journal of clinical pharmacology, 1994, Volume: 38, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diazepam; Humans; In Vitro Techniques; Isoenzymes; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Nordazepam; Temazepam

1994
Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3

    Topics: Animals; Kinetics; Male; Mice; Microsomes, Liver; Nordazepam; Oxazepam; Perfusion; Proteins; Temazepam

1993
Benzodiazepine misuse by drug addicts.
    Annals of clinical biochemistry, 1997, Volume: 34 ( Pt 1)

    Topics: Alcoholism; Benzodiazepines; Chromatography, High Pressure Liquid; Diazepam; Humans; Narcotics; Nitrazepam; Nordazepam; Substance-Related Disorders; Temazepam

1997
Application of microdialysis to study the in vitro metabolism of drugs in liver microsomes.
    Journal of pharmaceutical and biomedical analysis, 1997, Volume: 16, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diazepam; Ibuprofen; Kinetics; Microdialysis; Microsomes, Liver; Nordazepam; Rats; Salicylates; Salicylic Acid; Temazepam

1997
Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam.
    Biochemical pharmacology, 1998, Mar-15, Volume: 55, Issue:6

    Topics: Cytochrome P-450 Enzyme System; Diazepam; DNA, Complementary; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kinetics; Linear Models; Microsomes, Liver; Nordazepam; Temazepam

1998
Rapid and simple chromatographic method for the determination of diazepam and its major metabolites in human plasma and urine.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Apr-24, Volume: 708, Issue:1-2

    Topics: Calibration; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Humans; Nordazepam; Oxazepam; Reference Values; Temazepam

1998
Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.
    The Biochemical journal, 1999, Jun-15, Volume: 340 ( Pt 3)

    Topics: Adult; Allosteric Regulation; Allosteric Site; Antibodies, Monoclonal; Catalysis; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Models, Chemical; Nordazepam; Oxidation-Reduction; Temazepam

1999
The simultaneous determination of diazepam and its three metabolites in dog plasma by high-performance liquid chromatography with mass spectroscopy detection.
    Journal of pharmaceutical and biomedical analysis, 2001, Volume: 26, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Dogs; Mass Spectrometry; Nordazepam; Oxazepam; Reproducibility of Results; Temazepam

2001
Effects of diazepam and its metabolites on nocturnal melatonin secretion in the rat pineal and Harderian glands. A comparative in vivo and in vitro study.
    Chronobiology international, 2003, Volume: 20, Issue:2

    Topics: Animals; Circadian Rhythm; Diazepam; Harderian Gland; In Vitro Techniques; Male; Melatonin; Nordazepam; Oxazepam; Perfusion; Pineal Gland; Rats; Rats, Wistar; Temazepam

2003
Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes.
    Toxicology and applied pharmacology, 2009, Jan-15, Volume: 234, Issue:2

    Topics: Anti-Inflammatory Agents; Antithyroid Agents; Biotransformation; Cell Separation; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dexamethasone; Diazepam; Enzyme Induction; Hepatocytes; Humans; Hypnotics and Sedatives; Models, Biological; Models, Statistical; Nordazepam; Organ Culture Techniques; Oxazepam; Phenobarbital; Temazepam

2009
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
    Pain medicine (Malden, Mass.), 2009, Volume: 10, Issue:3

    Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin; Drug Overdose; Female; Heroin Dependence; Humans; Hydrocodone; Malpractice; Methadone; Nordazepam; Pain; Pain Measurement; Practice Guidelines as Topic; Shoulder; Shoulder Injuries; Temazepam

2009
Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE.
    Talanta, 2009, Nov-15, Volume: 80, Issue:1

    Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Nordazepam; Oxazepam; Rats; Reproducibility of Results; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Temazepam

2009
Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam.
    Xenobiotica; the fate of foreign compounds in biological systems, 2010, Volume: 40, Issue:1

    Topics: Acetonitriles; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diazepam; Dimethyl Sulfoxide; GABA Modulators; Humans; Kinetics; Methanol; Microsomes, Liver; Nordazepam; Solvents; Temazepam

2010
Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay.
    Annals of clinical biochemistry, 2010, Volume: 47, Issue:Pt 2

    Topics: Benzodiazepines; Biological Assay; Calibration; Chromatography, Liquid; European Union; Immunoassay; Limit of Detection; Nitrazepam; Nordazepam; Oxazepam; Sensitivity and Specificity; Tandem Mass Spectrometry; Temazepam

2010
Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes.
    Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:3

    Topics: Adult; Animals; Bioreactors; Biotransformation; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Diazepam; Female; Hepatocytes; Humans; Inactivation, Metabolic; Liver, Artificial; Male; Nordazepam; Oxazepam; Swine; Temazepam; Young Adult

2011
Reduction of temazepam to diazepam and lorazepam to delorazepam during enzymatic hydrolysis.
    Analytical and bioanalytical chemistry, 2011, Volume: 400, Issue:1

    Topics: Benzodiazepines; Chromatography, Liquid; Diazepam; Glucuronidase; Humans; Hydrolysis; Lorazepam; Mass Spectrometry; Nordazepam; Reference Standards; Temazepam

2011
Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma.
    Journal of analytical toxicology, 2012, Volume: 36, Issue:7

    Topics: Azabicyclo Compounds; Benzodiazepines; Chromatography, Liquid; Humans; Liquid-Liquid Extraction; Lorazepam; Mass Spectrometry; Nordazepam; Oxazepam; Piperazines; Plasma; Pyridines; Serum; Specimen Handling; Tandem Mass Spectrometry; Temazepam; Triazolam; Zolpidem

2012
Direct determination of diazepam and its glucuronide metabolites in human whole blood by μElution solid-phase extraction and liquid chromatography-tandem mass spectrometry.
    Forensic science international, 2013, Dec-10, Volume: 233, Issue:1-3

    Topics: Chromatography, Liquid; Diazepam; Forensic Toxicology; Humans; Hypnotics and Sedatives; Limit of Detection; Nordazepam; Oxazepam; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Temazepam

2013
Urinary diazepam metabolite distribution in a chronic pain population.
    Journal of analytical toxicology, 2014, Volume: 38, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chronic Pain; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diazepam; Drug Interactions; Esomeprazole; Female; Fluoxetine; Humans; Male; Methadone; Nordazepam; Oxazepam; Retrospective Studies; Specimen Handling; Temazepam

2014
A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case.
    Forensic science international, 2014, Volume: 243

    Topics: Adult; Alprazolam; Benzodiazepines; Benzodioxoles; Chlordiazepoxide; Chromatography, Liquid; Diazepam; Humans; Hypnotics and Sedatives; Male; Mass Spectrometry; Nordazepam; Oxazepam; Psychotropic Drugs; Pyrrolidines; Substance-Related Disorders; Synthetic Cathinone; Temazepam

2014
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
    Epilepsy research, 2014, Volume: 108, Issue:10

    Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; Electroencephalography; Epilepsy, Temporal Lobe; Ethanol; Female; Kainic Acid; Mice; Nordazepam; Oxazepam; Seizures; Solvents; Temazepam; Water

2014
A comparative study of primary secondary amino (PSA) and multi-walled carbon nanotubes (MWCNTs) as QuEChERS absorbents for the rapid determination of diazepam and its major metabolites in fish samples by high-performance liquid chromatography-electrospray
    Journal of the science of food and agriculture, 2016, Jan-30, Volume: 96, Issue:2

    Topics: Adsorption; Animals; Chromatography, High Pressure Liquid; Diazepam; Fishes; Food Contamination; Nanotubes, Carbon; Nordazepam; Oxazepam; Seafood; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temazepam

2016
Characterization of equine cytochrome P450: role of CYP3A in the metabolism of diazepam.
    Journal of veterinary pharmacology and therapeutics, 2016, Volume: 39, Issue:5

    Topics: Animals; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP3A; Diazepam; Horses; Hypnotics and Sedatives; Male; Microsomes, Liver; Nordazepam; Oxazepam; Phylogeny; Protein Isoforms; Rats; Rats, Sprague-Dawley; Species Specificity; Temazepam

2016
Deposition of diazepam and its metabolites in hair following a single dose of diazepam.
    International journal of legal medicine, 2017, Volume: 131, Issue:1

    Topics: Adult; Asian People; Chromatography, Liquid; Diazepam; Female; Hair; Healthy Volunteers; Humans; Hypnotics and Sedatives; Male; Nordazepam; Oxazepam; Tandem Mass Spectrometry; Temazepam; Young Adult

2017
Pentobarbital in the context of possible suicides: Analysis of a Case.
    Forensic science international, 2017, Volume: 274

    Topics: Adult; Central Nervous System Depressants; Diazepam; Ethanol; Gastrointestinal Contents; Humans; Male; Nordazepam; Oxazepam; Pentobarbital; Suicide; Temazepam

2017
Rapid Extraction and Qualitative Screening of 30 Drugs in Oral Fluid at Concentrations Recommended for the Investigation of DUID Cases.
    Journal of analytical toxicology, 2022, Oct-14, Volume: 46, Issue:8

    Topics: 2-Propanol; 3,4-Methylenedioxyamphetamine; Alprazolam; Amphetamines; Buprenorphine; Carisoprodol; Clonazepam; Cocaine; Codeine; Dronabinol; Fentanyl; Hexanes; Hydrocodone; Hydromorphone; Lorazepam; Meprobamate; Methadone; Methamphetamine; Morphine Derivatives; N-Methyl-3,4-methylenedioxyamphetamine; Nordazepam; Oxazepam; Oxycodone; Oxymorphone; Pharmaceutical Preparations; Phencyclidine; Tandem Mass Spectrometry; Temazepam; Tramadol; Zolpidem

2022
Occurrence of Z-drugs, benzodiazepines, and ketamine in wastewater in the United States and Mexico during the Covid-19 pandemic.
    The Science of the total environment, 2023, Jan-20, Volume: 857, Issue:Pt 2

    Topics: Alprazolam; Benzodiazepines; Clonazepam; COVID-19; Diazepam; Humans; Ketamine; Lorazepam; Mexico; Nordazepam; Pandemics; Tandem Mass Spectrometry; Temazepam; United States; Wastewater; Zolpidem

2023