nordazepam has been researched along with diazepam in 379 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 240 (63.32) | 18.7374 |
| 1990's | 69 (18.21) | 18.2507 |
| 2000's | 31 (8.18) | 29.6817 |
| 2010's | 30 (7.92) | 24.3611 |
| 2020's | 9 (2.37) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, RJ; Gall, M; Kamdar, BV | 1 |
| Blair, T; Webb, GA | 1 |
| Aoyama, T; Ichikawa, H; Suzuki, Y | 1 |
| Blanton, CD; Fatmi, AA; Iturrian, WB; Vaidya, NA | 1 |
| Lukovits, I | 1 |
| Babbini, M; Barbaro, AM; Bartoletti, M; Biagi, GL; Borea, PA; Gaiardi, M; Guerra, MC | 1 |
| Lopata, A; Lukovits, I | 1 |
| Johnston, GA; Maddalena, DJ | 1 |
| Karplus, M; So, SS | 1 |
| Ghuloum, AM; Jain, AN; Sage, CR | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Ertl, P; Rohde, B; Selzer, P | 1 |
| Artursson, P; Luthman, K; Norinder, U; Stenberg, P | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Caron, G; Ermondi, G | 1 |
| Fitos, I; Mády, G; Simonyi, M; Visy, J; Zsila, F | 1 |
| Du-Cuny, L; Huwyler, J; Kansy, M; Wiese, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Carmona, AV; Kumari, S; Tiwari, AK; Trippier, PC | 1 |
| Clarke, CH; Ferres, HM; Nicholson, AN; Stone, BM | 1 |
| Golovenko, NIa; Zin'kovskii, VG | 1 |
| Erkkola, R; Kangas, L; Kanto, J; Piiroinen, O | 1 |
| Andreoli, V; Maffei, F; Montanaro, N; Morandini, G | 1 |
| Pape, BE; Ribick, MA | 1 |
| de Angelis, L; Traversa, U; Vertua, R | 1 |
| Bertler, A; Lindgren, S; Malmgren, H; Post, C | 1 |
| Dorrity, F; Linnoila, M | 1 |
| Greenblatt, DJ | 2 |
| Greenblatt, DJ; Shader, RI | 1 |
| Linnoila, M; Viukari, M | 1 |
| Allen, MD; Georgotas, A; Greenblatt, DJ; Harmatz, JS; Shader, RI | 1 |
| Airoldi, L; Lanzoni, J; Marcucci, F; Mussini, E | 1 |
| Baird, ES; Hailey, DM | 1 |
| Allen, MD; Bodem, G; Greenblatt, DJ; Harmatz, JS; Ochs, HR; Shader, RI | 1 |
| de Angelis, L; File, SE | 1 |
| Baars, AM; Hekster, YA; O'Reilly, WJ; van der Kleijn, E; Vree, TB | 1 |
| Georgotas, A; Greenblatt, DJ; Harmatz, JS; Shader, RI | 1 |
| 't Hart, BJ; de Gier, JJ | 1 |
| Bugge, A | 1 |
| Fresia, P; Govoni, S; Spano, PF; Trabucchi, M | 1 |
| Das, S; Datta, SC; Dey, S; Guin, AK; Sengupta, D | 1 |
| Kangas, L; Korttila, K | 1 |
| Antonin, KH; Bieck, PR; Brügel, H; Klotz, U | 1 |
| Cesco, G; Fabbruci, I; Giannico, S; Montanaro, N; Scaggiante, L | 1 |
| Lader, M | 1 |
| Rutherford, DM | 1 |
| Clarke, CH; Nicholson, AN | 2 |
| Klotz, U | 2 |
| Khoo, KC; Posmanter, HN; Puglisi, CV; Weinfeld, RE | 1 |
| Airoldi, L; Facchinetti, T; Garattini, S; Marcucci, F; Mussini, E | 1 |
| Cano, JP; Reynier, JP; Rispe, R; Viala, A | 1 |
| Steyn, JM; van der Merew, PJ | 1 |
| Kabra, PM; Marton, LJ; Stevens, GL | 1 |
| Brodie, RR; Chasseaud, LF; Taylor, T | 1 |
| Perchalski, RJ; Wilder, BJ | 1 |
| Cleary, W; Eng, L; McMillan, S; Missen, AW | 1 |
| Okoko, A; Rutherford, DM; Tyrer, PJ | 1 |
| Haataja, M; Hurme, P; Kanto, J; Sellman, R | 1 |
| Ishihama, H; Kimata, H | 1 |
| Ishihama, H; Kimata, H; Matsumoto, S | 1 |
| Allen, MD; Greenblatt, DJ; Orsulak, PJ; Shader, RI; Woo, E | 1 |
| Sun, SR | 1 |
| Babbini, M; Bartoletti, M; Gaiardi, M | 1 |
| Helmsing, PJ; van der Woude, J; van Eupen, OM | 1 |
| Bredesen, JE; Langslet, A; Lunde, PK; Meberg, A | 2 |
| Konishi, M | 1 |
| Klotz, U; Müller-Seydlitz, P | 1 |
| Dhar, AK; Kutt, H | 1 |
| Cohen, ME; Duffner, PK; Jusko, WJ; MacKichan, JJ | 1 |
| Bartenbach, D; Carrigan, PJ | 1 |
| Kanto, J; Mäenpää, M; Mäntylä, R; Sellman, R; Valovirta, E | 1 |
| Schwertner, HA; Shimek, EL; Wallace, JE | 1 |
| Miller, F; Nulsen, J | 1 |
| Aderjan, R; Schmidt, G | 1 |
| Delaney, M; Dixon, R; Earley, J; Glover, W | 1 |
| Sellers, EM; Wong, GB | 1 |
| Cook, L; Grodsky, FS; Sepinwall, J | 1 |
| Allen, MD; Greenblatt, DJ; MacLaughlin, DS; Sahder, RI; Weinberger, DR | 1 |
| Brooks, MA; Dixon, R; Hackman, MR; Moore, JD; Postma, E; Schwartz, MA; Spector, S | 1 |
| Antonin, KH; Bieck, PR; Klotz, U | 1 |
| Alberti, GG; De Maio, D; Franciosi, P; Gomeni, R; Scieghi, G; Tognoni, G | 1 |
| Hanifl, E; Rosenmund, H; Wad, N | 1 |
| Beischlag, TV; Inaba, T; Kalow, W; Mahon, WA | 1 |
| Constant, H; Duthel, JM; Miachon, S; Rochet, T; Vallon, JJ | 1 |
| Guentert, TW; Stebler, T | 2 |
| Chiba, K; Ishizaki, T; Jang, IJ; Kusaka, M; Shin, JG; Shin, SG; Sohn, DR | 1 |
| Bruce, I; Hooper, WD; Reilly, PE | 1 |
| de la Rey, N; Hundt, HK; Luus, HG; Meyer, BH; Müller, FO; Röthig, HJ | 1 |
| Basile, AS; Harrison, PM; Hughes, RD; Jones, EA; Murata, Y; Pannell, L; Skolnick, P; Williams, R | 1 |
| Dickey, KM; Martin, WR; Sloan, JW; Wala, E | 1 |
| Martin, WR; Sloan, JW; Wala, EP | 2 |
| Corcoran, KD; Lukey, BJ; Solana, RP | 1 |
| Anthenelli, RM; Blunt, B; Monteiro, MG; Schuckit, MA | 1 |
| Hooper, WD; Mason, SR; Reilly, PE; Thompson, DA | 1 |
| Benazzi, F | 1 |
| Hole, K; Rosland, JH | 1 |
| Wong, PT | 1 |
| Andersson, T; Cederberg, C; Edvardsson, G; Heggelund, A; Lundborg, P | 1 |
| Dusci, LJ; Good, SM; Hall, RW; Ilett, KF | 1 |
| Caccia, S; Conti, I; Tridico, RV | 1 |
| Heikkinen, H; Heinälä, P; Piepponen, T | 1 |
| Eckardt, MJ; Granger, A; Lane, E; Linnoila, M; Lister, R; Moss, H; Stapleton, JM | 1 |
| Andersson, T; Andrén, K; Cederberg, C; Edvardsson, G; Heggelund, A; Lundborg, P | 1 |
| Camsonne, R | 1 |
| Bertilsson, L; Henthorn, TK; Sanz, E; Säwe, J; Tybring, G; Villén, T | 1 |
| Klotz, U; Unseld, E | 1 |
| Kubo, H; Miura, H; Nishida, A; Nishikawa, T; Ohtani, H; Sudo, Y; Sunaoshi, W | 1 |
| Fischer, C; Klotz, U; Krishna, DR; Unseld, E | 1 |
| Chenery, RJ; Lockwood, GF; Seddon, T | 1 |
| Corrie, JE; Dowie, LJ; Fraser, R; Gray, CE; Holloway, CD; Kenyon, CJ | 1 |
| Friedman, H; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Shader, RI | 1 |
| D'Eramo, C; Iacovelli, W; Salvadori, A; Stocchetti, N | 1 |
| Iwaya, N; Miyoshi, K; Morita, Y | 1 |
| Appel, M; Bron, HN; Hooymans, PM; Janknegt, R | 1 |
| Benetello, P; Bertin, I; Colombo, G; Furlanut, M | 1 |
| Fassbender, CP; Hönack, D; Löscher, W | 1 |
| D'Eramo, C; Maestri, D; Tirelli, F | 2 |
| Klockowski, PM; Levy, G | 3 |
| Bertolissi, M; de Angelis, L; Della Loggia, R; Nardini, G; Traversa, U; Vertua, R | 1 |
| Bergert, RJ; Deutsch, DG; Soo, VA | 1 |
| Spealman, RD | 2 |
| Greenblatt, DJ; Harmatz, JS; Locniskar, A; Shader, RI; Zinny, MA | 1 |
| Bareggi, SR; Leva, S; Lorini, M; Nielsen, NP; Pirola, R; Zecca, L | 1 |
| Greenblatt, DJ; Locniskar, A; Ochs, HR; Weinbrenner, J | 1 |
| Bertolotti, G; Galdangelo, F; Mazzuero, G; Tavazzi, L; Zotti, AM | 1 |
| Barone, D; Garattini, S; Gobbi, M; Mennini, T | 1 |
| D'Eramo, C; Follini, L; Stocchetti, N; Taverna, A; Zennaro, F | 1 |
| Dammann, HG; Gottlieb, W; Keohane, PP; Klotz, U | 1 |
| Badian, M; Hundt, HK; Joubert, AL; Luus, HG; Meyer, BH; Müller, FO | 1 |
| Bareggi, SR; Leva, S; Pirola, R; Smirne, S; Truci, G; Zecca, L | 1 |
| Bareggi, SR; Leva, S; Pirola, R; Smirne, S; Truci, G | 1 |
| Boxenbaum, HG; Divoll, MK; Greenblatt, DJ; Harmatz, JS; Shader, RI; Soong, MH | 1 |
| Corbo, M; Struzziero, E; Zeppa, G | 1 |
| Cafaggi, G; Ciotola, G; Ciritella, P; Di Gregorio, AM; Scafuro, M | 1 |
| Maurer, R; Möhler, H; Ranalder, U; Schmidt, K; Vetter, W; Wildmann, J | 1 |
| De Blas, AL; Fales, HM; Friedrich, P; Sangameswaran, L | 1 |
| Laufen, H; Leitold, M; Räder, K; Yeates, RA | 1 |
| Abernethy, DR; Friedman, H; Greenblatt, DJ; Shader, RI | 1 |
| Hasselstrøm, L; Ostergård, D; Ravnborg, M | 1 |
| Gwee, MC; Lee, HS; Wong, PT; Yoong, YL | 1 |
| Brase, DA; Dewey, WL; Glennon, RA; Young, R | 1 |
| Cowen, PJ; Franklin, M; Fraser, S; Gosden, B; Murdock, P; Nutt, DJ | 1 |
| Gumulka, SW; Janicki, PK; Jedrzejowska, H; Pisarski, W; Rewekant, M | 1 |
| Cone, EJ; Darwin, WD; Gorodetzky, CW; Griffiths, RR; Preston, KL | 1 |
| Bonanzinga, M; De Domenico, P; Di Perri, R; Gallitto, G; Musolino, R; Sacchi, C; Troilo, G | 1 |
| Ecobichon, DJ; Ungar, W | 1 |
| Chan, M; Ko, W; Kumana, CR; Lauder, IJ; Lin, HJ | 1 |
| Dolan, S; Lau, CE; Tang, M | 1 |
| Alazia, M; Cano, JP; Crevat-Pisano, P; Drouet, C; Francois, G; Lacarelle, B | 1 |
| Kanto, J; Scheinin, M | 1 |
| Hole, K; Hunskaar, S; Rosland, JH | 1 |
| Bareggi, SR; Ferrario, P; Pirola, R; Zecca, L | 1 |
| Boisse, NR; Guarino, JJ; Samoriski, GM | 1 |
| Igarashi, T; Kitagawa, H; Ohmori, S; Okiyama, M; Ueno, K | 1 |
| Bergstrom, RF; Bosomworth, JC; Lemberger, L; Rowe, H; Tenbarge, JB | 1 |
| Martin, WR; McNicholas, LF; Sloan, JW; Wala, E | 1 |
| Beightol, LA; Farthing, D; Karnes, HT; Serafin, RJ | 1 |
| Imamura, T; Kimura, K; Kudo, K; Nagata, T; Noda, M | 1 |
| García Ruiz, A; Gómez Luque, A; Martos Crespo, F; Sánchez de la Cuesta, F | 1 |
| Brown, C; File, SE; Greenblatt, DJ; Martin, IL | 1 |
| Clarke, P; Ewen, JM; Stevenson, IH; Swift, CG | 1 |
| Moroji, T; Motomura, H; Noguchi, T; Sekiguchi, R; Tada, K | 1 |
| Berwish, NJ; Bond, WS; Swift, B | 1 |
| Löscher, W; Schwark, WS | 1 |
| Gugler, R; Jensen, JC | 1 |
| Martin, WR; McNicholas, LF; Pruitt, TA | 1 |
| Lee, HS; Low, PS; Quak, SH; Ti, TY; Wong, HB | 1 |
| Ellinwood, EH; Heatherly, D; Nikaido, A | 1 |
| Davenport, R; Haidukewych, D; Rodin, EA | 1 |
| Meeles, MT; Thys, CP; Tjaden, UR; van der Kaay, M | 1 |
| Paradiso, L; Rapisarda, V | 1 |
| Dudkiewicz, J; Misterek, K | 1 |
| Vozeh, S | 1 |
| El-Hazmi, MA | 1 |
| Ballabio, M; Caccia, S; Carli, M; Garattini, S; Samanin, R | 1 |
| Burrows, GD; Fulton, A; Maguire, KP; Norman, TR | 1 |
| Ciraulo, DA; Divoll, M; Georgotas, A; Greenblatt, DJ; Harmatz, JS; Shader, RI | 1 |
| Ciraulo, DA; Greenblatt, DJ; Harmatz, JS; Shader, RI | 1 |
| Dorow, RG; Schneider, HH; Seidler, J | 1 |
| Caccia, S; Cotecchia, S; Garattini, S; Mennini, T | 1 |
| Greenblatt, DJ; Knüchel, M; Locniskar, A; Ochs, HR; Steinhaus, E | 1 |
| Nicholson, AN | 1 |
| Kostowski, W; Lipińska, T; Puciłowski, O; Płaźnik, A; Trzaskowska, E | 1 |
| Löscher, W | 1 |
| Henderson, JG | 1 |
| Hashimoto, S; Mizobuchi, M; Momose, T; Sakurai, E; Takahashi, S; Yamamoto, K | 1 |
| Cocchi, R; Macci, F; Passanisi, S | 1 |
| Colin, P; Lelorier, J; Sirois, G | 1 |
| Coffey, B; Greenblatt, DJ; Shader, RI | 1 |
| Greenblatt, DJ; Kaschell, HJ; Ochs, HR; Rauh, HW | 1 |
| Betts, T; Crowe, A; Hawksworth, G; Knight, R; Nyemitei-Addo, I; Parry, K; Parsons, A; Petrie, JC; Raffle, A | 1 |
| Käferstein, H; Norpoth, T; Staak, M; Sticht, G | 1 |
| Allison, S; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Pary, RJ; Shader, RI | 1 |
| Arcidiacono, G; Cappelli, N; Cuoci, L; Fornaro, P; Guarneri, M; Moggi, G; Pacifici, GM; Placidi, GF | 1 |
| Greenblatt, DJ; Locniskar, A; Ochs, HR; Verburg-Ochs, B | 1 |
| Itoh, N; Mimaki, T; Ono, J; Tagawa, T; Tanaka, J; Terada, H; Yabuuchi, H | 1 |
| Dawling, S; Flanagan, RJ; Moreton, K; Riley, P; Treasaden, I; Tyrer, P | 1 |
| Agrawal, KK; Gupta, A; Tayal, G; Tekur, U | 1 |
| Greenblatt, DJ; Martyn, JA; Quinby, WC | 1 |
| Eckardt, B; Greenblatt, DJ; Harmatz, JS; Ochs, HR; Shader, RI | 1 |
| Abernethy, DR; Divoll, M; Greenblatt, DJ; Ochs, HR; Shader, RI | 1 |
| Brendle, A; Erwin, CW; Linnoila, M; Simpson, D | 1 |
| Ochs, HR | 2 |
| de Gier, JJ; t Hart, BJ; Wilting, J | 1 |
| Kuhnz, W; Nau, H | 1 |
| Greenblatt, DJ; Locniskar, A; Shader, RI | 1 |
| Ballabio, M; Caccia, S; Garattini, S; Guiso, G; Reginato, R | 1 |
| Colburn, WA; Jack, ML | 1 |
| Colburn, WA; Wills, RJ | 1 |
| Kuhnz, W; Luck, W; Nau, H | 1 |
| Colburn, WA; Cotler, S; Gustafson, JH | 1 |
| Abernethy, DR; Greenblatt, DJ; Harmatz, JS; Morse, DS; Shader, RI | 1 |
| Case, WG; Dixon, R; Downing, RW; Fridman, R; Rickels, K | 1 |
| Ghoneim, MM; Hinrichs, JV; Mewaldt, SP | 1 |
| Kuhnz, W; Luck, W; Nau, H; Wegener, S | 1 |
| Booij, LH; Crul, JF; Driessen, JJ; van Egmond, J; Vree, TB | 1 |
| Greenblatt, DJ; Ochs, HR; Verburg-Ochs, B | 1 |
| Busto, U; Harrison, M; Kaplan, HL; Naranjo, CA; Sellers, EM | 1 |
| Cuoci, L; Pacifici, GM; Placidi, GF | 1 |
| Rickels, K; Winokur, A | 1 |
| Frey, HH; Philippin, HP; Scheuler, W | 1 |
| McCurdy, HH; Rhodes, PJ; Rhodes, RS | 1 |
| Aranko, K; Aranko, S; Mattila, MJ; Seppälä, T | 1 |
| Bjornsson, TD; Kitchell, BB; Linnoila, M; Routledge, PA; Shand, DG; Skinner, T | 1 |
| Abel, JG; Giles, HG; Naranjo, CA; Sellers, EM | 1 |
| Klotz, U; Reimann, I | 3 |
| Hallstrom, C; Lader, MH | 1 |
| Kolenda, KD | 1 |
| Allen, MD; Greenblatt, DJ; Harmatz, JS; Shader, RI | 1 |
| Müller, FO; Steyn, JM | 1 |
| Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL | 1 |
| Dietrichson, P; Lossius, R; Lunde, PK | 1 |
| Dextraze, PG; Diamond, I; Foreman, JM; Griffiths, WC | 1 |
| Greenblatt, DJ; Lloyd, BL; Ochs, HR | 1 |
| Friel, PN; Graaff, PR; Opheim, KE; Raisys, VA; Wilensky, AJ | 1 |
| Harris, SC; Shimek, EL; Wallace, JE | 1 |
| Elsass, P; Hansen, T; Hendel, J; Hvidberg, EF; Møller, IW; Sørensen, KH | 1 |
| Elsass, P; Gymoese, E; Hansen, T; Hendel, J; Hvidberg, EF; Rathje, J | 1 |
| Nel, P; Walters, L | 1 |
| Stenchever, MA; Williamson, RA | 1 |
| Allen, MD; Greenblatt, DJ; Harmatz, JS; Laughren, TP; Shader, RI | 1 |
| Abernethy, DR; Greenblatt, DJ | 1 |
| Divoll, M; Greenblatt, DJ; Lacasse, Y; Shader, RI | 1 |
| Britt, RH; Conley, FK; Hollister, LE; Shuer, L | 1 |
| Bittencourt, PR; Richens, A; Smith, AT; Wade, P | 1 |
| Cazzullo, CL; Scarone, S; Strambi, LF | 1 |
| Dumont, CH; Rangno, RE; Sitar, DS | 1 |
| Dhillon, S; Richens, A | 2 |
| Divoll, M; Greenblatt, DJ | 1 |
| Bowden, CL; Fisher, JG | 1 |
| Gustafson, JH; Holazo, AA; Kaplan, SA; Khoo, KC; Weinfeld, RE; Weissman, L | 1 |
| Dixon, R | 1 |
| Greenblatt, DJ; Lauven, PM; Ochs, HR; Rommelsheim, K; Stoeckel, H | 1 |
| Fornaro, P; Gomeni, R; Pacifici, GM; Placidi, GF | 1 |
| Abernethy, DR; Divoll, M; Greenblatt, DJ; Shader, RI | 1 |
| Bosatra, A; Poli, P; Vertua, R | 1 |
| Frey, HH; Löscher, W | 1 |
| Battey, YW; Greenblatt, DJ; Laughren, TP | 1 |
| Bondiolotti, GP; Carruba, MO; Corli, O; Galva, MD; Picotti, GB | 1 |
| Aoyagi, N; Ejima, A; Kaniwa, N; Koibuchi, M; Nishida, Y; Ogata, H; Ogawa, Y; Shibazaki, T; Shimamoto, T; Uda, Y; Yashiki, T | 1 |
| Richter, K; Scherber, A | 1 |
| Greenblatt, DJ; Rickels, K; Schatz, NJ; Snyder, PJ; Winokur, A | 1 |
| Yang, SK | 1 |
| Chiba, K; Chiba, T; Hirano, T; Horii, H; Ishizaki, T; Kato, Y | 1 |
| Jing, X; Sloan, JW; Wala, EP | 2 |
| Caraco, Y; Tateishi, T; Wood, AJ | 1 |
| Chiba, K; Hayashi, M; Horai, Y; Ishizaki, T; Koyama, E; Manabe, K; Tomono, Y; Toyoki, T; Yamato, C; Yasuda, S | 1 |
| Conjeevaram, HS; Kaminsky-Russ, K; Mullen, KD | 1 |
| Ambre, J; de Wit, H; Dudish, S | 1 |
| Desor, D; Humbert, AC; Koziel, V; Nehlig, A; Schroeder, H | 1 |
| Capra, C; Casella, G; Costagli, V; Ramella, G; Sogni, A | 1 |
| Barel, S; Bialer, M; Cipolla, G; Gatti, G; Gips, M; Perucca, E; Soback, S; Spina, E | 1 |
| Andersson, T; Birkett, DJ; Miners, JO; Veronese, ME | 1 |
| Aantaa, R; Himberg, JJ; Kanto, J; Katila, A; Kirvelä, O | 1 |
| Basile, AS; Gu, ZQ; Harrison, PM; Hughes, RD; Jones, EA; McKinney, A; Pannell, L; Williams, R | 1 |
| Ihara, N; Kokufu, T; Nosaka, K; Ohta, T; Sugioka, N | 1 |
| Kamali, F | 1 |
| Pang, KS; St-Pierre, MV | 1 |
| Alcorn, J; Papich, MG | 1 |
| Lu, Y; Pan, B; Wang, D | 1 |
| Franke, M; Kingston, HM; Winek, CL | 1 |
| Chaba, P; Dziklińska, A; Kur, E; Matsumoto, H; Skalski, M; Stencka, K; Szelenberger, W; Wasilewski, D; Woźny, E | 1 |
| Sloan, JW; Wala, EP | 1 |
| Jindrová, O; Lamka, J | 1 |
| Berry, D; Fernandes, C; File, SE | 1 |
| Baldinelli, L; Consolati, E; Cordioli, G; Galzigna, L; Luisetto, F; Manani, G | 1 |
| Garretty, DJ; Hay, AW; Raistrick, D; Wolff, K | 1 |
| Dressler, C; Franke, KP; Herzig, M; Nagel, U | 1 |
| Baris, BA; Gardner, MJ; Preskorn, SH; Wilner, KD | 1 |
| Bolognesi, R; Conti, M; Manca, C; Tsialtas, D; Vasini, P | 1 |
| Court, MH; Greenblatt, DJ; Norman, WM | 1 |
| Camaris, C; Little, D | 1 |
| Gunaratna, C; Kissinger, PT | 1 |
| Camara, P; Davidson, D; Fitz, E; Rosen, S; Swift, R | 1 |
| Ardizzone, G; Arrigo, A; Avallone, R; Baraldi, M; Centanaro, M; Corsi, L; Farina, F; Kleinschnitz, M; Schreier, P; Venturini, I; Zeneroli, ML | 1 |
| Brown, S; Patsalos, PN; Shorvon, SD; Tong, X; Walker, MC | 1 |
| Gelboin, HV; Gonzalez, FJ; Korzekwa, KR; Shou, M; Yang, SK; Yang, TJ | 1 |
| Ali, HM; Azzam, RM; Notarianni, LJ | 1 |
| Hemmersbach, P; Ragnar Norli, H; Rasmussen, KE; Reubsaet, KJ | 1 |
| Baillie, TA; Dai, R; Ettore, MW; Mei, Q; Rushmore, TH; Shou, M | 1 |
| He, N; Huang, SL; Ou-Yang, DS; Qin, XP; Wang, W; Wang, YJ; Xie, HG; Xu, ZH; Zhou, HH | 1 |
| Kristensen, PA; Moller, JT; Rasmussen, H; Rasmussen, LS; Steentoft, A | 1 |
| Atta-Politou, J; Dona, A; Koutselinis, A; Parissi-Poulou, M | 1 |
| Schmoldt, A; Schulz, M; Stein, S | 1 |
| Krogh, M; Rasmussen, KE; Ugland, HG | 1 |
| Arditti, J; Bourdon, JH; de Haro, L; Hayek-Lanthois, M; Iliadis, A; Valli, M | 1 |
| Mørland, J; Olsen, KM; Skuterud, B; Smith-Kielland, A | 1 |
| Contel, N; Grossman, S; Liu, Z; Ren, S; Rose, A; Short, J; Unger, S | 1 |
| Bell, RR; Crookham, SB; Dunn, WA; Grates, KM; Reiber, TM | 1 |
| Bergman, J; Knebel, N; Munzar, P; Paronis, C; Redhi, G; Tober, C; Yasar, S; Zschiesche, M | 1 |
| Djeridane, Y; Touitou, Y | 1 |
| Andersson, TB; Bredberg, E; Eriksson, UG; Eriksson-Lepkowska, M; Frison, L; Johansson, S; Larsson, M; Thuresson, A | 1 |
| Holmgren, P; Jones, AW | 1 |
| Jones, AW; Larsson, H | 1 |
| Holmgren, A; Holmgren, P; Jones, AW | 1 |
| Atta-Politou, J; Panderi, I; Valavani, P | 1 |
| Musteata, FM; Musteata, ML; Pawliszyn, J | 1 |
| Grubwieser, P; Libiseller, K; Pavlic, M; Rabl, W; Schubert, H | 1 |
| Bouchonnet, S; Kinani, S; Milan, N; Ricordel, I | 1 |
| Bertilsson, L; Laine, K; Neuvonen, PJ; Olkkola, KT; Saari, TI | 1 |
| Barroso, M; Gallardo, E; Margalho, C; Monsanto, P; Vieira, DN | 1 |
| Lehmann, C; Wannarka, GL | 1 |
| Acikgöz, A; Bader, A; Giri, S; Karim, N; Schmidt-Heck, W | 1 |
| Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS | 1 |
| Iannello, C; Mandrioli, R; Matrisciano, F; Mercolini, L; Nicoletti, F; Raggi, MA | 1 |
| Abe, K; Kobayashi, N; Nakamura, K; Nishiya, Y; Okazaki, O; Okudaira, N | 1 |
| Chronister, CW; Goldberger, BA; Merves, ML | 1 |
| Acikgöz, A; Bader, A; Giri, S; Maringka, M; Nieber, K | 1 |
| Mariani, CL; Musulin, SE; Papich, MG | 1 |
| Bowron, P; Fu, S; Lewis, J; Molnar, A; Wang, H | 1 |
| KuKanich, B; Nauss, JL | 1 |
| Andrews, P; Lamson, MJ; Mesa, M; Pellock, J; Sitki-Green, D; Wannarka, GL | 1 |
| Holmgren, A; Jones, AW | 1 |
| Roth, T; Verster, JC | 1 |
| Cox, S; Martin, T; Moyers, TD; Probst, CW; Thomas, WB | 1 |
| Charabidze, D; Delabarde, T; Keyser, C; Ludes, B; Tracqui, A | 1 |
| Burch, HJ; Clarke, EJ; Hubbard, AM; Scott-Ham, M | 1 |
| Breborowicz, GH; Florek, E; Krzyscin, M; Kulza, M; Lechowicz, E; Markwitz, W; Mazela, J; Merritt, TA; Miechowicz, I; Piekoszewski, W; Senczuk-Przybylowska, M | 1 |
| Liang, C; Ni, C; Rao, Y; Wang, R; Wang, X; Xiong, L; Zhang, Y | 1 |
| Atayee, RS; Best, BM; Luk, S; Ma, JD | 1 |
| Bertol, E; Boscolo Berto, R; Favretto, D; Mannaioni, G; Mari, F; Vaiano, F | 1 |
| Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W | 1 |
| Li, J; Liu, H; Wu, L; Zhang, J | 1 |
| Aboul-Enein, HY; Adib, N; Talebpour, Z; Torabizadeh, M | 1 |
| Darwish, WS; Hayami, A; Ikenaka, Y; Ishizuka, M; Kawai, YK; Mizukawa, H; Nakayama, SM; Watanabe, KP | 1 |
| Jia, J; Jiang, F; Johansen, SS; Linnet, K; Rao, Y; Wang, X; Zhang, Y | 1 |
| Castro, A; Costa, P; Franco, JM; Melo, P; Quintas, MJ; Tarelho, S; Teixeira, HM | 1 |
| Boxho, P; Charlier, C; Denooz, R; Dubois, N; Lemaire, E; Schmidt, C | 1 |
| Du, P; Gao, T; Hou, L; Li, J; Li, X; Wang, C; Xu, Z; Yang, J; Zhang, H | 1 |
| Bugelli, V; Campobasso, CP; Chericoni, S; Fornaro, S; Giusiani, M; Papi, L; Stefanelli, F; Vanin, S | 1 |
| Barclay, VKH; Johansson, IM; Pettersson, CE; Tyrefors, NL | 1 |
| Concheiro, M; Cooper, G; Mei, V; Pardi, J | 1 |
| Andresen-Streichert, H; Froch-Cortis, J; Lehmann, S; Mercer-Chalmers-Bender, K; Rothschild, MA; Sczyslo, A; Thevis, M | 1 |
| Cui, GF; He, Y; Ren, XX; Wang, LL; Wei, ZW; Yun, KM | 1 |
| Falcon, M; Fernadez-Lopez, L; Luna, A; Mancini, R; Pellegrini, M; Rotolo, M | 1 |
| Ballardini, M; Carelli, C; Freni, F; Moretti, M; Morini, L; Vignali, C | 1 |
| Broussou, D; Düe, M; Lagershausen, H; Lallemand, E; Machnik, M; Meuly, A; Roques, BB; Röttgen, H; Schenk, I; Thevis, M; Toutain, PL | 1 |
| Diogo, HP; Ramos, JJM | 1 |
| Burkat, PM | 1 |
| Frankenfeld, F; Jacobs, CM; Meyer, MR; Wagmann, L | 1 |
| Adhikari, S; Barron, LP; Bhatnagar, A; Bowes, DA; Coronado-Apodaca, KG; Driver, EM; Halden, RU; Kumar, R; Martínez-Ruiz, M; McCall, KL; Melchor-Martínez, EM; Ng, KT; Oyervides-Muñoz, MA; Parra-Saldivar, R; Piper, BJ; Smith, T; Sosa-Hernandez, JE | 1 |
10 review(s) available for nordazepam and diazepam
| Article | Year |
|---|---|
Neural networks applied to quantitative structure-activity relationship analysis.
Topics: Animals; Azirines; Benzodiazepines; Carbazilquinone; Nerve Net; Nervous System; Regression Analysis; Structure-Activity Relationship | 1990 |
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.
Topics: Amides; Carbamates; Click Chemistry; Drug Design; Pyridines; Structure-Activity Relationship; Triazoles; Urea | 2020 |
[Clinical pharmacokinetics of diazepam and its biologically active metabolites (author's transl)].
Topics: Biotransformation; Diazepam; Half-Life; Humans; Kinetics; Models, Biological; Nordazepam; Oxazepam | 1978 |
Benzodiazepines: are they of natural origin?
Topics: Animals; Benzodiazepines; Diazepam; Nordazepam | 1989 |
[Current intravenous anesthetics].
Topics: Anesthesia, Intravenous; Anesthetics; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Etomidate; Flunitrazepam; Imidazoles; Injections, Intravenous; Lorazepam; Medazepam; Midazolam; Nordazepam | 1980 |
Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics.
Topics: Adolescent; Adult; Age Factors; Aged; Benzodiazepines; Biotransformation; Child; Diazepam; Flurazepam; Half-Life; Humans; Kinetics; Middle Aged; Nordazepam; Oxidation-Reduction | 1983 |
[Benzodiazepines: significance of kinetics for therapy].
Topics: Age Factors; Aged; Benzodiazepines; Diazepam; Humans; Kinetics; Metabolic Clearance Rate; Nordazepam; Sex Factors; Triazolam | 1983 |
[Drug catabolism and its significance for pharmacotherapy].
Topics: Biotransformation; Cytochrome P-450 Enzyme System; Diazepam; Digitoxin; Digoxin; Drug Interactions; Drug Therapy; Drug Therapy, Combination; Enzyme Induction; Ethanol; Kidney; Kidney Diseases; Liver; Liver Diseases; Nordazepam; Receptors, Drug | 1980 |
Studies of "endogenous" benzodiazepine in human hepatic encephalopathy.
Topics: Animals; Benzodiazepines; Diazepam; Hepatic Encephalopathy; Humans; Models, Biological; Nordazepam | 1993 |
Blood drug concentrations of benzodiazepines correlate poorly with actual driving impairment.
Topics: Anti-Anxiety Agents; Automobile Driving; Diazepam; GABA-A Receptor Agonists; Humans; Nordazepam; Psychomotor Performance | 2013 |
65 trial(s) available for nordazepam and diazepam
| Article | Year |
|---|---|
Effect of N-desmethyldiazepam (nordiazepam) and a precursor, potassium clorazepate, on sleep in man.
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Clorazepate Dipotassium; Diazepam; Humans; Male; Nordazepam; Sleep; Sleep Stages; Time Factors | 1976 |
Double-blind cross-over clinical comparison of two 2'-chloro benzodiazepines: 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (chlordesmethyldiazepam) versus 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (
Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Brief Psychiatric Rating Scale; Clinical Trials as Topic; Diazepam; Drug Evaluation; Female; Humans; Lorazepam; Middle Aged; Nordazepam; Psychiatric Status Rating Scales | 1977 |
Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide.
Topics: Adult; Aged; Aluminum Hydroxide; Anti-Anxiety Agents; Clinical Trials as Topic; Clorazepate Dipotassium; Diazepam; Drug Combinations; Female; Humans; Hypnotics and Sedatives; Intestinal Absorption; Kinetics; Magnesium; Magnesium Hydroxide; Male; Middle Aged; Nordazepam; Time Factors | 1978 |
Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease.
Topics: Adult; Biological Availability; Biotransformation; Clinical Trials as Topic; Diazepam; Half-Life; Hepatitis; Humans; Liver; Liver Cirrhosis; Liver Diseases; Middle Aged; Nordazepam | 1977 |
Single-blind evaluation of hypnotic activity of chlordesmethyldiazepam in No-placebo-reactor medical patients.
Topics: Clinical Trials as Topic; Diazepam; Drug Evaluation; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Nordazepam; Placebos; Sleep Initiation and Maintenance Disorders | 1977 |
Activity of N-desmethyldiazepam (nordiazepam) [proceedings].
Topics: Adult; Diazepam; Humans; Male; Motor Skills; Nordazepam | 1977 |
Immediate and residual effects in man of the metabolites of diazepam.
Topics: Adult; Choice Behavior; Diazepam; Humans; Male; Motor Skills; Nordazepam; Oxazepam; Placebos; Reaction Time; Temazepam; Time Factors | 1978 |
Plasma concentration of diazepam and N-desmethyldiazepam in children after a single rectal or intramuscular dose of diazepam.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Humans; Hypnotics and Sedatives; Injections, Intramuscular; Nordazepam; Rectum; Suppositories; Time Factors | 1978 |
Effect of a cocktail on diazepam absorption.
Topics: Adult; Alcoholic Beverages; Diazepam; Ethanol; Female; Humans; Intestinal Absorption; Kinetics; Male; Nordazepam | 1978 |
Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline.
Topics: Adult; Aged; Clinical Trials as Topic; Diazepam; Drug Evaluation; Drug Therapy, Combination; Half-Life; Humans; Male; Middle Aged; Nordazepam; Nortriptyline; Placebos; Sleep Initiation and Maintenance Disorders | 1975 |
The effects of felodipine on the pharmacokinetics of diazepam.
Topics: Adult; Diazepam; Double-Blind Method; Drug Interactions; Felodipine; Humans; Male; Nordazepam | 1992 |
Amnestic effects of intravenous diazepam in healthy young men.
Topics: Adolescent; Adult; Diazepam; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Male; Memory, Short-Term; Mental Recall; Nordazepam; Retention, Psychology; Verbal Learning | 1991 |
Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Humans; Male; Metabolic Clearance Rate; Nordazepam; Omeprazole; Random Allocation | 1990 |
Effects of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers.
Topics: Adult; Affect; Alprazolam; Anxiety; Autonomic Nervous System; Cognition; Diazepam; Drug Interactions; Ethanol; Female; Humans; Nordazepam; Norepinephrine; Psychomotor Performance | 1990 |
Effect of omeprazole and cimetidine on plasma diazepam levels.
Topics: Adult; Cimetidine; Diazepam; Double-Blind Method; Drug Interactions; Half-Life; Humans; Male; Nordazepam; Omeprazole | 1990 |
Double-blind placebo cross-over study of long-acting (chlordesmethyldiazepam) versus short-acting (lorazepam) benzodiazepines in generalized anxiety disorders.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Diazepam; Double-Blind Method; Female; Humans; Lorazepam; Male; Middle Aged; Nordazepam; Psychiatric Status Rating Scales | 1989 |
[Chlordesmethyldiazepam and prolactinemia during surgical stress].
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Humans; Male; Middle Aged; Nordazepam; Preanesthetic Medication; Prolactin; Stress, Physiological; Surgery, Plastic; Surgical Procedures, Operative; Thiopental | 1989 |
Influence of propranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam following intravenous clorazepate.
Topics: Adult; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazepam; Drug Interactions; Female; Humans; Infusions, Intravenous; Kinetics; Male; Metabolic Clearance Rate; Nordazepam; Propranolol; Smoking | 1986 |
Effects of propranolol, atenolol, and chlordesmethyldiazepam on response to mental stress in patients with recent myocardial infarction.
Topics: Adult; Aged; Anti-Anxiety Agents; Atenolol; Benzodiazepines; Diazepam; Electrocardiography; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Nordazepam; Propranolol; Psychophysiology; Stress, Psychological | 1987 |
Nocturnal doses of ranitidine and nizatidine do not affect the disposition of diazepam.
Topics: Adult; Diazepam; Drug Interactions; Histamine H2 Antagonists; Humans; Male; Nizatidine; Nordazepam; Ranitidine; Thiazoles | 1987 |
Effects of HOE 760 (histamine H2-receptor antagonist) on diazepam pharmacokinetics.
Topics: Adult; Clinical Trials as Topic; Diazepam; Double-Blind Method; Half-Life; Histamine H2 Antagonists; Humans; Male; Nordazepam; Piperidines; Time Factors | 1988 |
Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans.
Topics: Absorption; Administration, Oral; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Biological Availability; Diazepam; Half-Life; Humans; Injections, Intravenous; Male; Nordazepam; Random Allocation; Tablets; Time Factors | 1988 |
[Effects of chlordemethyldiazepam on blood cortisol during surgical stress].
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Diazepam; Humans; Hydrocortisone; Male; Middle Aged; Nordazepam; Preanesthetic Medication; Random Allocation; Stress, Physiological; Surgical Procedures, Operative | 1988 |
Premedication with oral and rectal diazepam.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anesthesia, General; Anxiety; Diazepam; Double-Blind Method; Drug Evaluation; Humans; Kinetics; Middle Aged; Nordazepam; Preanesthetic Medication; Random Allocation; Rectum; Time Factors | 1986 |
Diazepam and methadone blood levels following concurrent administration of diazepam and methadone.
Topics: Adult; Chromatography, Thin Layer; Diazepam; Drug Interactions; Humans; Immunoenzyme Techniques; Kinetics; Male; Meiosis; Methadone; Nordazepam | 1986 |
Diazepam: prediction of pharmacodynamics from pharmacokinetics.
Topics: Adult; Diazepam; Humans; Kinetics; Male; Nordazepam; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Steady-state plasma desmethyldiazepam during long-term clorazepate use: effects of antacids.
Topics: Adult; Aluminum Hydroxide; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazepam; Drug Combinations; Drug Interactions; Female; Gastric Acid; Humans; Magnesium; Magnesium Hydroxide; Male; Nordazepam; Time Factors | 1982 |
A radioreceptor assay to study the affinity of benzodiazepines and their receptor binding activity in human plasma including their active metabolites.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Biotransformation; Blood Proteins; Diazepam; Female; Humans; Lorazepam; Male; Nitrazepam; Nordazepam; Protein Binding; Radioligand Assay; Receptors, Drug; Receptors, GABA-A | 1982 |
Desmethyldiazepam kinetics after intravenous, intramuscular, and oral administration of clorazepate dipotassium.
Topics: Administration, Oral; Adult; Aged; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazepam; Female; Half-Life; Humans; Injections, Intramuscular; Injections, Intravenous; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Nordazepam | 1982 |
Value of a single night-time dose of potassium clorazepate in anxiety: a controlled trial comparison with diazepam.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Blood Pressure; Clinical Trials as Topic; Clorazepate Dipotassium; Diazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Nordazepam; Patient Compliance; Psychological Tests | 1982 |
Diazepam/beta-adrenoceptor antagonist interactions.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Animals; Atenolol; Diazepam; Drug Interactions; Emotions; Humans; In Vitro Techniques; Kinetics; Male; Metoprolol; Microsomes, Liver; Nordazepam; Propranolol; Psychomotor Performance; Rats; Rats, Inbred Strains; Reaction Time; Visual Acuity | 1984 |
Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Clorazepate Dipotassium; Diazepam; Double-Blind Method; Emotions; Female; Humans; Intestinal Absorption; Kinetics; Male; Nordazepam; Prazepam; Sleep | 1984 |
Psychomotor effects of diazepam in anxious patients and healthy volunteers.
Topics: Adult; Anxiety Disorders; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Nordazepam; Personality Inventory; Psychiatric Status Rating Scales; Psychomotor Performance | 1983 |
Clinical importance of the interaction of diazepam and cimetidine.
Topics: Adult; Anxiety; Cimetidine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Humans; Male; Middle Aged; Nordazepam; Psychomotor Performance; Reaction Time; Sleep Wake Disorders | 1984 |
Dose-response analysis of the behavioral effects of diazepam: II. Psychomotor performance, cognition and mood.
Topics: Adolescent; Adult; Circadian Rhythm; Cognition; Diazepam; Dose-Response Relationship, Drug; Emotions; Half-Life; Humans; Nordazepam; Posture; Psychomotor Performance | 1984 |
Withdrawal responses to abrupt discontinuation of desmethyldiazepam.
Topics: Acute Disease; Adult; Anxiety Disorders; Clinical Trials as Topic; Depression; Diazepam; Feeding and Eating Disorders; Female; Half-Life; Humans; Nausea; Nordazepam; Placebos; Psychiatric Status Rating Scales; Sleep Wake Disorders; Substance Withdrawal Syndrome | 1984 |
Anxiety and sedation during a stressful situation after single dose of diazepam versus N-desmethyldiazepam--a controlled trial.
Topics: Adult; Anxiety; Breast Neoplasms; Diazepam; Double-Blind Method; Drug Evaluation; Emotions; Female; Humans; Hypnotics and Sedatives; Middle Aged; Nordazepam | 1980 |
Kinetics and neuropsychologic effects of IV diazepam in the presence and absence of its active N-desmethyl metabolite in humans.
Topics: Adolescent; Adult; Anxiety; Diazepam; Electroencephalography; Emotions; Female; Humans; Injections, Intravenous; Kinetics; Male; Nordazepam; Reaction Time | 1980 |
The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.
Topics: Adult; Benzodiazepines; Diazepam; Double-Blind Method; Eye Movements; Flurazepam; Humans; Male; Nitrazepam; Nordazepam; Reticular Formation; Saccades; Temazepam | 1981 |
Effects of two dosages of chlordesmethyldiazepam on mnestic-information processes in normal subjects.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Diazepam; Double-Blind Method; Humans; Male; Memory; Mental Recall; Nordazepam; Random Allocation | 1981 |
Clearance of diazepam can be impaired by its major metabolite desmethyldiazepam.
Topics: Adult; Diazepam; Humans; Metabolic Clearance Rate; Nordazepam | 1981 |
Relationship of diazepam serum level to antianxiety effects.
Topics: Adult; Anxiety Disorders; Chromatography, Gas; Chromatography, High Pressure Liquid; Diazepam; Female; Humans; Male; Middle Aged; Nordazepam; Personality Inventory | 1982 |
Effects of oral chlordemethyldiazepam on plasma adrenaline and noradrenaline and cardiovascular reactivity in preoperative patients.
Topics: Abortion, Induced; Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Blood Pressure; Diazepam; Epinephrine; Female; Heart Rate; Hemodynamics; Humans; Nordazepam; Norepinephrine; Plethysmography; Pregnancy; Preoperative Care | 1982 |
Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study.
Topics: Adult; Anxiety; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Nordazepam; Substance Withdrawal Syndrome; Substance-Related Disorders | 1980 |
Interethnic difference in omeprazole's inhibition of diazepam metabolism.
Topics: Adult; Asian People; China; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Diazepam; Double-Blind Method; Drug Interactions; Ethnicity; Humans; Male; Mephenytoin; Nordazepam; Omeprazole; Tennessee; White People | 1995 |
Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Analysis of Variance; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Half-Life; Humans; Hydroxylation; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Omeprazole; Proton Pump Inhibitors; Rabeprazole; Reference Values; Single-Blind Method | 1995 |
Subjective and behavioral effects of diazepam depend on its rate of onset.
Topics: Adult; Affect; Alcohol Drinking; Behavior; Breath Tests; Cognition; Diazepam; Double-Blind Method; Euphoria; Humans; Male; Nordazepam; Psychomotor Performance; Sleep | 1993 |
[Preanesthesia in elderly patients undergoing subarachnoid anesthesia: chlordesmethyldiazepam versus diazepam].
Topics: Aged; Anesthesia, Spinal; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Female; Humans; Male; Nordazepam; Preanesthetic Medication | 1994 |
Inhibition of diazepam metabolism by fluvoxamine: a pharmacokinetic study in normal volunteers.
Topics: Adult; Biotransformation; Diazepam; Female; Fluvoxamine; Humans; Male; Nordazepam | 1994 |
Metabolic and subjective responses to oral diazepam and midazolam.
Topics: Administration, Oral; Adult; Arousal; Calorimetry, Indirect; Carbon Dioxide; Cognition; Diazepam; Double-Blind Method; Energy Metabolism; Humans; Hypnotics and Sedatives; Male; Memory; Midazolam; Monitoring, Physiologic; Nordazepam; Oxygen Consumption; Placebos | 1994 |
Absorption of diazepam after its rectal administration in dogs.
Topics: Absorption; Administration, Rectal; Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Cross-Over Studies; Diazepam; Dogs; Dose-Response Relationship, Drug; Fluorescence Polarization Immunoassay; Injections, Intravenous; Male; Nordazepam; Oxazepam; Time Factors | 1995 |
[Determination of diazepam concentration in maternal and fetal serum after intravenous administration during active phase of labor and its effects on neonates].
Topics: Adult; Apgar Score; Asphyxia Neonatorum; Diazepam; Female; Fetal Blood; Humans; Infant, Newborn; Injections, Intravenous; Labor Onset; Nordazepam; Pregnancy | 1995 |
Premedication with chlordemethyldiazepam and anxiolytic effect of diazepeam in implantology.
Topics: Adult; Anesthesia, Dental; Anti-Anxiety Agents; Benzodiazepines; Chi-Square Distribution; Dental Anxiety; Dental Implantation; Diazepam; Female; Humans; Male; Middle Aged; Nordazepam; Preanesthetic Medication | 1995 |
Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers.
Topics: 1-Naphthylamine; Adolescent; Adult; Anti-Anxiety Agents; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Blood Proteins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Double-Blind Method; Drug Interactions; Humans; Male; Mixed Function Oxygenases; Nordazepam; Protein Binding; Selective Serotonin Reuptake Inhibitors; Sertraline | 1997 |
Naltrexone effects on diazepam intoxication and pharmacokinetics in humans.
Topics: Adult; Affect; Aged; Anti-Anxiety Agents; Central Nervous System Depressants; Diazepam; Ethanol; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Nordazepam; Psychomotor Performance | 1998 |
Benzodiazepines and postoperative cognitive dysfunction in the elderly. ISPOCD Group. International Study of Postoperative Cognitive Dysfunction.
Topics: Abdomen; Age Factors; Aged; Aged, 80 and over; Anesthesia, General; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Female; Humans; Male; Middle Aged; Nordazepam; Postoperative Complications; Psychometrics; Regression Analysis | 1999 |
A modified simple and rapid reversed phase liquid chromatographic method for quantification of diazepam and nordiazepam in plasma.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Calibration; Chromatography, High Pressure Liquid; Diazepam; Female; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Middle Aged; Nordazepam; Reference Standards; Reproducibility of Results; Solvents | 1999 |
Urinary excretion of diazepam metabolites in healthy volunteers and drug users.
Topics: Adult; Anti-Anxiety Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Creatinine; Diazepam; Female; Humans; Male; Middle Aged; Nordazepam; Oxazepam; Substance Abuse Detection; Substance-Related Disorders; Temazepam | 2001 |
Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions.
Topics: Administration, Oral; Adult; Aged; Amidines; Anticoagulants; Area Under Curve; Azetidines; Benzylamines; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Diclofenac; Drug Interactions; Glycine; Humans; In Vitro Techniques; Infusions, Intravenous; Microsomes, Liver; Middle Aged; Nifedipine; Nordazepam; Prodrugs; Thrombin | 2003 |
Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit.
Topics: Adult; Body Water; Chromatography, Gas; Diazepam; Erythrocytes; Female; Hematocrit; Humans; In Vitro Techniques; Male; Middle Aged; Nordazepam; Plasma; Sex Factors | 2004 |
Voriconazole and fluconazole increase the exposure to oral diazepam.
Topics: Administration, Oral; Adult; Antifungal Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cognition; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Enzyme Inhibitors; Female; Fluconazole; Genotype; Half-Life; Humans; Hypnotics and Sedatives; Male; Mixed Function Oxygenases; Nordazepam; Pyrimidines; Triazoles; Voriconazole; Wakefulness | 2007 |
Bioavailability and dose proportionality of intramuscular diazepam administered by autoinjector.
Topics: Adult; Anticonvulsants; Area Under Curve; Biotransformation; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Humans; Injections, Intramuscular; Male; Nordazepam; Therapeutic Equivalency | 2008 |
Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Diazepam; Dogs; Dosage Forms; Drug Administration Routes; Female; Half-Life; Male; Nordazepam; Oxazepam | 2011 |
Pharmacokinetics of diazepam administered intramuscularly by autoinjector versus rectal gel in healthy subjects: a phase I, randomized, open-label, single-dose, crossover, single-centre study.
Topics: Administration, Rectal; Adult; Anticonvulsants; Area Under Curve; Cross-Over Studies; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Injections, Intramuscular; Male; Nordazepam; Young Adult | 2011 |
Evaluation of plasma diazepam and nordiazepam concentrations following administration of diazepam intravenously or via suppository per rectum in dogs.
Topics: Administration, Rectal; Animals; Anticonvulsants; Area Under Curve; Cross-Over Studies; Diazepam; Dogs; Female; Half-Life; Injections, Intravenous; Male; Nordazepam; Suppositories | 2013 |
304 other study(ies) available for nordazepam and diazepam
| Article | Year |
|---|---|
Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Hydroxylation; Male; Methods; Mice; Oxidation-Reduction; Triazolam; Triazoles | 1978 |
Electronic factors in the structure-activity relationship of some 1,4-benzodiazepin-2-ones.
Topics: Benzodiazepinones; Electrochemistry; Structure-Activity Relationship | 1977 |
Synthesis of previously inaccessible quinazolines and 1,4-benzodiazepines as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Benzodiazepines; Mice; Pentylenetetrazole; Quinazolines; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
Quantitative structure-activity relationships employing independent quantum chemical indices.
Topics: Amines; Benzodiazepines; Benzylamines; Mathematics; Quantum Theory; Structure-Activity Relationship; Tetracyclines | 1983 |
Rm values and structure-activity relationship of benzodiazepines.
Topics: Animals; Benzodiazepines; Chromatography, Thin Layer; Conflict, Psychological; Exploratory Behavior; Models, Biological; Rats; Solubility; Structure-Activity Relationship | 1980 |
Decomposition of pharmacological activity indices into mutually independent components using principal component analysis.
Topics: Animals; Anti-Infective Agents; Benzodiazepines; Hydroxyquinolines; Mathematics; Pharmacology; Rifamycins; Seizures; Statistics as Topic; Structure-Activity Relationship | 1980 |
Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks.
Topics: Binding Sites; Ligands; Neural Networks, Computer; Predictive Value of Tests; Receptors, GABA-A; Structure-Activity Relationship | 1995 |
Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors.
Topics: Algorithms; Benzodiazepines; Models, Genetic; Nerve Net; Protein Binding; Receptors, GABA-A; Structure-Activity Relationship | 1996 |
Molecular hashkeys: a novel method for molecular characterization and its application for predicting important pharmaceutical properties of molecules.
Topics: Drug Design; Intestinal Absorption; Models, Molecular; Pharmaceutical Preparations; Structure-Activity Relationship | 1999 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties.
Topics: Biological Availability; Biological Transport; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Reproducibility of Results | 2000 |
Experimental and computational screening models for the prediction of intestinal drug absorption.
Topics: Biological Transport; Carbon Radioisotopes; Cell Line; Cell Membrane; Cell Membrane Permeability; Ciprofloxacin; Computational Biology; Drug Design; Foscarnet; Humans; Hydrogen Bonding; Intestinal Absorption; Intestinal Mucosa; Lactulose; Mannitol; Models, Biological; Raffinose; Surface Properties; Tritium; Verapamil | 2001 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Conformation selectivity in the binding of diazepam and analogues to alpha1-acid glycoprotein.
Topics: Circular Dichroism; Diazepam; Genetic Variation; Humans; Molecular Conformation; Orosomucoid; Protein Binding; Serum Albumin | 2007 |
Computational aqueous solubility prediction for drug-like compounds in congeneric series.
Topics: Benzodiazepines; Computer Simulation; Crystallography, X-Ray; Databases, Factual; Least-Squares Analysis; Models, Chemical; Organic Chemicals; Pharmaceutical Preparations; Principal Component Analysis; Solubility; Sulfonamides; Water | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred CBA; Nordazepam; Oxazepam; Pentylenetetrazole; Seizures; Time Factors | 1976 |
Feto-maternal concentrations of diazepam and W-demethyldiazepam after intra-amniotic diazepam injection.
Topics: Adolescent; Adult; Amniotic Fluid; Brain Chemistry; Diazepam; Female; Fetal Blood; Humans; Injections; Injections, Intramuscular; Kinetics; Liver; Maternal-Fetal Exchange; Nordazepam; Oxazepam; Pregnancy | 1976 |
Analysis of medazepam, diazepam, and metabolites in plasma by gas-liquid chromatography with electrolytic conductivity detection.
Topics: Anti-Anxiety Agents; Chromatography, Gas; Chromatography, Liquid; Diazepam; Electric Conductivity; Medazepam; Microchemistry; Nordazepam | 1977 |
On the hypnogenic and anticonvulsant activities of demethyldiazepam and chlordemethyldiazepam: time-effect relations.
Topics: Animals; Anticonvulsants; Chlorprothixene; Diazepam; Female; Hexobarbital; Hypnotics and Sedatives; Mice; Nordazepam; Pentylenetetrazole; Time Factors | 1977 |
Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate.
Topics: Adult; Anti-Anxiety Agents; Body Weight; Clorazepate Dipotassium; Diazepam; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Nordazepam | 1977 |
Rapid gas chromatographic assay of serum diazepam, N-desmethyldiazepam, and N-desalkylflurazepam.
Topics: Anti-Anxiety Agents; Chromatography, Gas; Diazepam; Flurazepam; Humans; Nordazepam; Time Factors | 1977 |
Determination of desmethyldiazepam in plasma by electron-capture GLC: application to pharmacokinetic studies of clorazepate.
Topics: Anti-Anxiety Agents; Chromatography, Gas; Clorazepate Dipotassium; Diazepam; Female; Humans; Kinetics; Nordazepam; Time Factors | 1978 |
Pharmacokinetic understanding of antianxiety drug therapy.
Topics: Adult; Anti-Anxiety Agents; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Dose-Response Relationship, Drug; Humans; Nordazepam; Oxazepam; Prazepam | 1978 |
Serum medazepam, diazepam, and N-desmethyldiazepam levels after single and multiple oral doses of medazepam.
Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Chemical Phenomena; Chemistry; Diazepam; Humans; Intellectual Disability; Male; Medazepam; Nordazepam | 1977 |
Gas chromatographic determination of chlorodesmethyldiazepam and lorazepam in rats and mice.
Topics: Adipose Tissue; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Chromatography, Gas; Diazepam; Kinetics; Lorazepam; Male; Mass Spectrometry; Methods; Mice; Nordazepam; Rats | 1979 |
Plasma concentrations of medazepam and its metabolites after oral administration.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Diazepam; Humans; Male; Medazepam; Nordazepam; Time Factors | 1979 |
Effect of age and Billroth gastrectomy on absorption of desmethyldiazepam from clorazepate.
Topics: Adult; Age Factors; Aged; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazepam; Female; Gastrectomy; Humans; Intestinal Absorption; Male; Middle Aged; Nordazepam | 1979 |
Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Humans; Interpersonal Relations; Lighting; Male; Mice; Nordazepam; Time Factors | 1979 |
Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.
Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Dogs; Humans; Nordazepam; Oxazepam; Species Specificity; Temazepam | 1979 |
Self-rated sedation and plasma concentrations of desmethyldiazepam following single doses of clorazepate.
Topics: Adult; Aged; Anti-Anxiety Agents; Biotransformation; Clorazepate Dipotassium; Diazepam; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Nordazepam | 1979 |
Sensitive gas chromatographic method for the determination of diazepam and N-desmethyldiazepam in plasma.
Topics: Chromatography, Gas; Diazepam; Humans; Nordazepam | 1979 |
Quantitative high-performance liquid chromatography of diazepam and N-desmethyldiazepam in blood.
Topics: Chromatography, High Pressure Liquid; Diazepam; Forensic Medicine; Methods; Microchemistry; Nordazepam; Silicon Dioxide | 1976 |
Effect of desmethyldiazepam and chlordesmethyldiazepam on 3',5'-cyclic guanosine monophosphate levels in rat cerebellum.
Topics: Age Factors; Animals; Animals, Newborn; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; gamma-Aminobutyric Acid; Male; Nordazepam; Rats | 1976 |
In vitro effects of diazepam, desmethyldiazepam & nitrazepam on ATPase activity of human fetal brain.
Topics: Adenosine Triphosphatases; Brain; Calcium-Transporting ATPases; Cell-Free System; Diazepam; Humans; Microsomes; Nitrazepam; Nordazepam; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 1979 |
Unchanged protein binding and the increase of serum diazepam levels after food intake.
Topics: Adult; Diazepam; Dietary Carbohydrates; Dietary Fats; Eating; Fatty Acids, Nonesterified; Humans; Injections, Intravenous; Male; Nordazepam; Protein Binding; Time Factors | 1977 |
Allergy to diazepam.
Topics: Cross Reactions; Diazepam; Humans; Nordazepam | 1977 |
Rapid micro-method for the measurement of diazepam and desmethyldiazepam in blood plasma by gas-liquid chromatography.
Topics: Chromatography, Gas; Chromatography, Liquid; Diazepam; Humans; Methods; Microchemistry; Nordazepam; Solvents | 1977 |
[Important factors determining human distribution and elimination of diazepam].
Topics: Animals; Biological Availability; Diazepam; Dogs; Guinea Pigs; Humans; Liver; Nordazepam; Protein Binding; Rabbits; Rats | 1977 |
Rapid determination of diazepam and nordiazepam in plasma by electron capture gas--liquid chromatography. Application in clinical pharmacokinetic studies.
Topics: Autoanalysis; Chromatography, Gas; Chromatography, Liquid; Diazepam; Humans; Nordazepam | 1977 |
Hydroxylation of three benzodiazepines in vitro.
Topics: Animals; Biotransformation; Diazepam; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nordazepam; Rats | 1977 |
Determination of N-desmethyldiazepam in plasma by gas chromatography with an internal standard.
Topics: Chromatography, Gas; Diazepam; Dose-Response Relationship, Drug; Humans; Nordazepam | 1978 |
Thin-layer chromatographic method for determination of diazepam and its major metabolite, N-desmethyldiazepam, in human serum.
Topics: Chromatography, Thin Layer; Diazepam; Humans; Nordazepam | 1978 |
High-pressure liquid chromatographic analysis of diazepam, oxazepam and N-desmethyldiazepam in human blood.
Topics: Chromatography, High Pressure Liquid; Diazepam; Humans; Nordazepam; Oxazepam | 1978 |
High-performance liquid chromatographic determination of benzodiazepines in human plasma.
Topics: Chromatography, High Pressure Liquid; Diazepam; Humans; Nordazepam | 1978 |
Determination of benzodiazepine anticonvulsants in plasma by high-performance liquid chromatography.
Topics: Benzodiazepinones; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Humans; Nordazepam; Spectrophotometry, Ultraviolet | 1978 |
Diazepam, alcohol and drivers.
Topics: Accidents, Traffic; Automobile Driving; Diazepam; Ethanol; Humans; Legislation as Topic; New Zealand; Nordazepam; Wounds and Injuries | 1978 |
Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.
Topics: Adult; Age Factors; Aged; Diazepam; Female; Humans; Male; Middle Aged; Nordazepam; Sex Factors; Time Factors | 1978 |
Plasma and urine concentrations of diazepam and its metabolites in children, adults and in diazepam-intoxicated patients.
Topics: Adult; Aging; Biotransformation; Child; Creatinine; Diazepam; Female; Humans; Infant; Infant, Newborn; Kinetics; Male; Nordazepam; Oxazepam | 1978 |
[Binding of prazepam, desalkylprazepam and diazepam to human serum albumin (author's transl)].
Topics: Diazepam; Humans; Nordazepam; Prazepam; Protein Binding; Serum Albumin | 1978 |
[Studies on metabolism of prazepam. II. Metabolism of prazepam, diazepam and desalkylprazepam by rat liver microsomes (author's transl)].
Topics: Animals; Diazepam; In Vitro Techniques; Microsomes, Liver; Nordazepam; Prazepam; Rats | 1978 |
Rapid recovery from massive diazepam overdose.
Topics: Adult; Biotransformation; Diazepam; Female; Half-Life; Humans; Male; Middle Aged; Nordazepam; Oxazepam; Remission, Spontaneous; Suicide, Attempted; Temazepam; Time Factors | 1978 |
Simultaneous gas-chromatographic analysis for diazepam and its major metabolite, desmethyldiazepam, with use of double internal standardization.
Topics: Adult; Benzodiazepinones; Chromatography, Gas; Diazepam; Female; Humans; Nordazepam; Reference Standards | 1978 |
Fluorescence--TLC densitometric determination of diazepam and other 1,4-benzodiazepines in serum.
Topics: Benzodiazepines; Chromatography, Thin Layer; Densitometry; Diazepam; Humans; Methods; Nordazepam; Oxazepam; Spectrometry, Fluorescence | 1978 |
Influence of the 2'-chloro substitution on central activity of desmethyldiazepam.
Topics: Animals; Avoidance Learning; Behavior, Animal; Choice Behavior; Diazepam; Electroencephalography; Male; Motor Activity; Nordazepam; Rats; Structure-Activity Relationship | 1978 |
A micromethod for simultaneous estimation of blood levels of some commonly used antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Chromatography, High Pressure Liquid; Diazepam; Humans; Microchemistry; Nordazepam; Phenobarbital; Phenytoin | 1978 |
Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration.
Topics: Administration, Oral; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injections, Intramuscular; Injections, Intravenous; Nordazepam; Pregnancy; Rectum; Seizures; Time Factors | 1978 |
Dose-dependent pharmacokinetics of 7-chloro-1,3-dihydro-5-(2'-chlorophenyl)-2H-1,4-benzodiazepin-2-one in dogs.
Topics: Animals; Diazepam; Dogs; Dose-Response Relationship, Drug; Kinetics; Male; Models, Biological; Nordazepam | 1978 |
Altered elimination of desmethyldiazepam in the elderly.
Topics: Adult; Aged; Aging; Diazepam; Half-Life; Humans; Liver; Nordazepam; Time Factors | 1979 |
Monitoring diazepam and desmethyldiazepam concentrations in plasma by gas-liquid chromatography, with use of a nitrogen-sensitive detector.
Topics: Chromatography, Gas; Diazepam; Epilepsy; Humans; Microchemistry; Nitrogen; Nordazepam | 1979 |
Liquid-chromatographic assay of diazepam and its major metabolites in plasma.
Topics: Chromatography, High Pressure Liquid; Diazepam; Humans; Nordazepam; Oxazepam | 1979 |
Elimination half-life of nordiazepam.
Topics: Diazepam; Half-Life; Humans; Kinetics; Nordazepam | 1979 |
Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia.
Topics: Adult; Age Factors; Aged; Anesthesia, Spinal; Body Water; Diazepam; Humans; Kinetics; Middle Aged; Nordazepam; Oxazepam; Temazepam | 1979 |
Analysis for diazepam and nordiazepam by electron-capture gas chromatography and by liquid chromatography.
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Diazepam; Humans; Methods; Nordazepam | 1979 |
Single case study. Diazepam (Valium) detoxification.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Metabolic Clearance Rate; Nordazepam; Substance Withdrawal Syndrome; Substance-Related Disorders | 1979 |
[A screening radioimmunoassay for 1,4-benzodiazepines in human blood, serum, and urine using anti-oxazepam-hemisuccinate-antibodies (author's transl)].
Topics: Benzodiazepines; Chromatography, Gas; Chromatography, Thin Layer; Diazepam; Humans; Nordazepam; Oxazepam; Radioimmunoassay; Succinates | 1979 |
Desmethyldiazepam: a specific radioimmunoassay.
Topics: Antibody Specificity; Diazepam; Humans; Methods; Nordazepam; Radioimmunoassay | 1979 |
Intravascular factors affecting diazepam binding to human serum albumin.
Topics: Binding, Competitive; Dialysis; Diazepam; Fatty Acids; Humans; Nordazepam; Oleic Acids; Oxazepam; Palmitic Acids; Protein Binding; Serum Albumin | 1979 |
Conflict behavior in the squirrel monkey: effects of chlordiazepoxide, diazepam and N-desmethyldiazepam.
Topics: Animals; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Haplorhini; Male; Nordazepam; Reinforcement Schedule; Saimiri; Time Factors | 1978 |
N-desmethyldiazepam: a new metabolite of chlordiazepoxide in man.
Topics: Animals; Chlordiazepoxide; Chromatography, Gas; Diazepam; Humans; Nordazepam; Rabbits; Radioimmunoassay; Time Factors | 1976 |
Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.
Topics: Adult; Animals; Blood Proteins; Body Surface Area; Diazepam; Dogs; Guinea Pigs; Half-Life; Humans; Kinetics; Male; Nordazepam; Protein Binding; Rabbits; Rats; Species Specificity; Swine | 1976 |
A simplified quantitative method for the simultaneous determination of diazepam and its metabolites in serum by thin-layer chromatography.
Topics: Absorption; Chromatography, Thin Layer; Diazepam; Hot Temperature; Methods; Nordazepam | 1976 |
Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin.
Topics: Animals; Chromatography, Gas; Diazepam; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Mephenytoin; Methylation; Nordazepam; Polymorphism, Genetic; Rats; Temazepam | 1992 |
Quantitation by gas chromatography with selected-ion monitoring mass spectrometry of "natural" diazepam, N-desmethyldiazepam and oxazepam in normal human serum.
Topics: Adult; Analysis of Variance; Diazepam; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Nordazepam; Oxazepam | 1992 |
Studies on the excretion of diazepam and nordazepam into milk for the prediction of milk-to-plasma drug concentration ratios.
Topics: Animals; Diazepam; Diffusion; Fats; Female; Infusions, Intravenous; Jugular Veins; Milk, Human; Models, Biological; Nordazepam; Pregnancy; Protein Binding; Rabbits | 1992 |
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.
Topics: Adult; Asian People; Creatinine; Diazepam; Female; Humans; Hydroxylation; Korea; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Polymorphism, Genetic | 1992 |
Comparative metabolism of clinically important precursors of N-desmethyldiazepam using phenobarbitone-pretreated rat liver microsomes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Hydroxylation; Male; Methylation; Microsomes, Liver; Nordazepam; Phenobarbital; Prazepam; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1992 |
Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure.
Topics: Adult; Aged; Benzodiazepines; Brain Chemistry; Chromatography; Diazepam; Flumazenil; Frontal Lobe; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Mass Spectrometry; Middle Aged; Nordazepam; Receptors, GABA-A; Synaptic Transmission | 1991 |
Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Diazepam; Dogs; Dose-Response Relationship, Drug; Flumazenil; Neurologic Examination; Nordazepam; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Distribution of diazepam, nordiazepam, and oxazepam between brain extraneuronal space, brain tissue, plasma, and cerebrospinal fluid in diazepam and nordiazepam dependent dogs.
Topics: Animals; Brain; Diazepam; Dogs; Extracellular Space; Female; Nordazepam; Oxazepam; Substance-Related Disorders | 1991 |
Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys.
Topics: Animals; Anticonvulsants; Blood Proteins; Diazepam; Hematocrit; Injections, Intramuscular; Macaca mulatta; Male; Nordazepam; Protein Binding; Seizures; Soman | 1991 |
Determination of diazepam and nordazepam in milk and plasma in the presence of oxazepam and temazepam.
Topics: Chromatography, High Pressure Liquid; Diazepam; Flurazepam; Humans; Hydrogen-Ion Concentration; Milk, Human; Nordazepam; Oxazepam; Temazepam | 1991 |
Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam.
Topics: Animals; Anti-Anxiety Agents; Cytochrome P-450 Enzyme System; Diazepam; Female; Hydroxylation; Kinetics; Male; Microsomes, Liver; Nordazepam; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Substrate Specificity; Temazepam | 1990 |
Depressive stupor treated with intramuscular chlordesmethyldiazepam.
Topics: Anti-Anxiety Agents; Arousal; Benzodiazepines; Depressive Disorder; Diazepam; Female; Humans; Injections, Intramuscular; Middle Aged; Nordazepam | 1990 |
Benzodiazepine-induced antagonism of opioid antinociception may be abolished by spinalization or blockade of the benzodiazepine receptor.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Diazepam; Flumazenil; Male; Mice; Midazolam; Morphine; Narcotics; Nordazepam; Psychomotor Performance; Reaction Time; Receptors, GABA-A; Receptors, Opioid; Skin Temperature; Spinal Cord | 1990 |
Characterization by saturation studies of the in vivo binding of [3H]flunitrazepam in mouse brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Flunitrazepam; Kinetics; Mice; Nordazepam; Oxazepam | 1991 |
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
Topics: Adult; Diazepam; Drug Combinations; Female; Humans; Infant; Milk, Human; Nordazepam; Oxazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Temazepam | 1990 |
Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; In Vitro Techniques; Liver; Male; Mixed Function Oxygenases; Nordazepam; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Diazepam loading in alcohol withdrawal: clinical pharmacokinetics.
Topics: Administration, Oral; Adult; Diazepam; Ethanol; Half-Life; Humans; Male; Middle Aged; Nordazepam; Substance Withdrawal Syndrome; Time Factors | 1990 |
Endogenous benzodiazepines in brain: right or wrong?
Topics: Benzodiazepines; Brain; Diazepam; Female; Humans; Male; Nordazepam | 1988 |
Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.
Topics: Adult; Benzodiazepines; Debrisoquin; Diazepam; Female; Humans; Hydantoins; Isoquinolines; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Smoking | 1989 |
Radioreceptor assay of clonazepam and diazepam in blood for therapeutic drug monitoring.
Topics: Adolescent; Animals; Child; Child, Preschool; Chromatography, Gas; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Flunitrazepam; Humans; Male; Nordazepam; Radioligand Assay; Rats | 1989 |
Detection of desmethyldiazepam and diazepam in brain of different species and plants.
Topics: Animals; Benzodiazepines; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Gas Chromatography-Mass Spectrometry; Humans; Nordazepam; Plants; Radioligand Assay; Species Specificity | 1989 |
In vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Diazepam; Liver; Macaca fascicularis; Male; Models, Biological; Nordazepam; Oxazepam; Oxygenases; Temazepam; Time Factors | 1989 |
Effect of the benzodiazepines diazepam, des-N-methyldiazepam and midazolam on corticosteroid biosynthesis in bovine adrenocortical cells in vitro; location of site of action.
Topics: Adrenal Cortex; Aldosterone; Animals; Benzodiazepines; Cattle; Diazepam; Hydrocortisone; In Vitro Techniques; Midazolam; Nordazepam | 1989 |
A large-sample study of diazepam pharmacokinetics.
Topics: Adolescent; Adult; Body Weight; Chromatography, Gas; Diazepam; Half-Life; Humans; Male; Nordazepam | 1989 |
[Control of the side effects of ketamine: chlordemethyldiazepam vs diazepam in pre-anesthesia].
Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Benzodiazepines; Blood Pressure; Child; Child, Preschool; Diazepam; Drug Evaluation; Female; Heart Rate; Humans; Infant; Infant, Newborn; Ketamine; Male; Nordazepam; Preanesthetic Medication | 1989 |
Determination of pharmacodynamics of diazepam by quantitative pharmaco-EEG.
Topics: Adult; Computer Systems; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Humans; Infusions, Intravenous; Male; Nordazepam; Reaction Time; Signal Processing, Computer-Assisted | 1989 |
Efficacy of flumazenil in COPD patient with therapeutic diazepam levels.
Topics: Aged; Diazepam; Drug Evaluation; Flumazenil; Humans; Lung Diseases, Obstructive; Male; Nordazepam | 1989 |
Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; Nordazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1989 |
Kinetics of drug action in disease states. XXV. Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam.
Topics: Animals; Cerebral Cortex; Diazepam; Kinetics; Male; Nordazepam; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Reflex; Shock | 1988 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; Electroshock; Male; Mice; Nordazepam; Pentylenetetrazole; Seizures | 1985 |
Screening and quantification of hypnotic sedatives in serum by capillary gas chromatography with a nitrogen-phosphorus detector, and confirmation by capillary gas chromatography-mass spectrometry.
Topics: Amobarbital; Barbiturates; Chromatography, Gas; Diazepam; Gas Chromatography-Mass Spectrometry; Humans; Hypnotics and Sedatives; Nordazepam; Pentobarbital; Secobarbital; Toxicology | 1986 |
Disruption of schedule-controlled behavior by Ro 15-1788 one day after acute treatment with benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Conditioning, Operant; Convulsants; Diazepam; Flumazenil; Male; Nordazepam; Reinforcement Schedule; Saimiri | 1986 |
Interaction of diazepam with famotidine and cimetidine, two H2-receptor antagonists.
Topics: Adult; Biotransformation; Cimetidine; Diazepam; Drug Interactions; Famotidine; Half-Life; Histamine H2 Antagonists; Humans; Infusions, Parenteral; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Nordazepam; Thiazoles | 1986 |
Age-related multiple-dose pharmacokinetics and anxiolytic effects of delorazepam (chlordesmethyldiazepam).
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Diazepam; Female; Humans; Kinetics; Male; Middle Aged; Nordazepam | 1986 |
Diazepam and desmethyldiazepam differ in their affinities and efficacies at 'central' and 'peripheral' benzodiazepine receptors.
Topics: Adrenal Glands; Animals; Benzodiazepines; Brain; Cerebellum; Cerebral Cortex; Diazepam; In Vitro Techniques; Male; Nordazepam; Rats; Receptors, GABA-A | 1987 |
[Chlordesmethyldiazepam as an anesthesia-inducing agent: time of loss of consciousness. Statistical analysis in man].
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Humans; Middle Aged; Nordazepam; Preanesthetic Medication; Time Factors; Unconsciousness | 1987 |
Effect of food on absorption of chlordemethyldiazepam.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Chromatography, Gas; Diazepam; Food; Half-Life; Humans; Intestinal Absorption; Male; Nordazepam | 1988 |
Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam.
Topics: Administration, Oral; Adult; Aged; Anti-Anxiety Agents; Biological Availability; Clorazepate Dipotassium; Diazepam; Female; Half-Life; Humans; Injections, Intravenous; Male; Middle Aged; Nordazepam | 1988 |
[A ketamine-chlordemethyldiazepam combination in celioscopy].
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Combinations; Drug Evaluation; Female; Humans; Ketamine; Laparoscopy; Middle Aged; Nordazepam | 1988 |
[Use of a chlordemethyldiazepam-fentanyl combination in invasive neuroradiologic examinations].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Evaluation; Drug Therapy, Combination; Female; Fentanyl; Humans; Male; Middle Aged; Neuroradiography; Nordazepam; Premedication | 1988 |
Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Female; Nordazepam; Oxazepam; Rats; Rats, Inbred Lew; Reflex; Temazepam | 1988 |
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine | 1985 |
Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin.
Topics: Adrenal Glands; Animals; Brain Chemistry; Cerebellum; Cerebral Cortex; Diazepam; Male; Nordazepam; Pituitary Gland; Rats; Specific Pathogen-Free Organisms; Tissue Extracts; Triticum | 1987 |
Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.
Topics: Animals; Antibodies, Monoclonal; Benzodiazepines; Brain Chemistry; Cattle; Chromatography, High Pressure Liquid; Diazepam; Humans; Immunologic Techniques; Mass Spectrometry; Nordazepam; Receptors, GABA-A; Spectrum Analysis | 1986 |
Preliminary study of the pharmacokinetics of desmethyldiazepam administered as drops or tablets.
Topics: Adult; Diazepam; Female; Humans; Kinetics; Male; Nordazepam; Sex Factors; Solutions; Tablets; Time Factors | 1986 |
The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma.
Topics: Animals; Blood Proteins; Brain; Diazepam; Half-Life; Male; Nordazepam; Protein Binding; Rats; Time Factors | 1986 |
Acute tolerance to diazepam in mice: pharmacokinetic considerations.
Topics: Animals; Brain Chemistry; Cycloheximide; Diazepam; Drug Tolerance; Kinetics; Male; Mice; Microsomes, Liver; Nordazepam | 1986 |
Potencies of diazepam metabolites in rats trained to discriminate diazepam.
Topics: Animals; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Nordazepam; Oxazepam; Rats; Rats, Inbred Strains; Temazepam | 1986 |
The effect of diazepam on indices of 5-HT function in man.
Topics: Adult; Blood Platelets; Diazepam; Humans; Hypnotics and Sedatives; Imipramine; Male; Nordazepam; Prolactin; Serotonin; Time Factors; Tryptophan | 1986 |
Serum concentrations of diazepam and its metabolite desmethyldiazepam in epileptic patients after chronic diazepam treatment.
Topics: Adult; Aged; Diazepam; Epilepsy; Humans; Middle Aged; Nordazepam | 1986 |
[Epilepsy induced by penicillin in rabbits: comparative study of the anticonvulsant effects of diazepam and chlordesmethyldiazepam].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Male; Nordazepam; Penicillins; Rabbits | 1986 |
Diazepam metabolism in the guinea pig materno-fetal model: effects of cigarette smoke.
Topics: Animals; Biotransformation; Dealkylation; Diazepam; Female; Guinea Pigs; Maternal-Fetal Exchange; Microsomes, Liver; Nordazepam; Pregnancy; Smoking | 1986 |
Differences in diazepam pharmacokinetics in Chinese and white Caucasians--relation to body lipid stores.
Topics: Adult; Asian People; Diazepam; Humans; Kinetics; Lipids; Male; Nordazepam; White People | 1987 |
Microsample determination of diazepam and its three metabolites in serum by reversed-phase high-performance liquid chromatography.
Topics: Animals; Biotransformation; Chlordiazepoxide; Chromatography, High Pressure Liquid; Diazepam; Hydrogen-Ion Concentration; Indicators and Reagents; Nordazepam; Rats; Spectrophotometry, Ultraviolet; Temazepam | 1987 |
Validation of a radioreceptor assay technique for monitoring pharmacological active material during intensive diazepam tetanus therapy.
Topics: Biotransformation; Chromatography, Gas; Cimetidine; Diazepam; Humans; Kinetics; Middle Aged; Nordazepam; Oxazepam; Radioligand Assay; Tetanus | 1987 |
Placental and blood-CSF transfer of orally administered diazepam in the same person.
Topics: Adult; Biotransformation; Diazepam; Female; Fetal Blood; Humans; Maternal-Fetal Exchange; Nordazepam; Oxazepam; Pregnancy | 1987 |
The effect of diazepam on nociception in mice.
Topics: Analgesics; Animals; Diazepam; Male; Mice; Nordazepam; Pain Measurement; Psychomotor Performance | 1987 |
Analysis of chlorodesmethyldiazepam and its metabolites in plasma and urine.
Topics: Anti-Anxiety Agents; Benzodiazepines; Chromatography, Gas; Diazepam; Glucuronates; Humans; Lorazepam; Nordazepam; Oxazepam | 1987 |
Simultaneous determination of diazepam and its active metabolites in rat serum, brain and cerebrospinal fluid by high-performance liquid chromatography.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Female; Nordazepam; Oxazepam; Postural Balance; Rats; Rats, Inbred Strains; Temazepam | 1987 |
Apparent lesser physical dependence potential of nor-diazepam compared to diazepam in the rat.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Male; Nordazepam; Rats; Rats, Inbred Strains; Substance-Related Disorders | 1987 |
Imipramine treatment alters the pharmacokinetics and pharmacodynamics of diazepam.
Topics: Animals; Blood Proteins; Brain Chemistry; Diazepam; Drug Interactions; Imipramine; Liver; Male; Nordazepam; Oxazepam; Pentylenetetrazole; Protein Binding; Rats; Rats, Inbred Strains; Temazepam | 1987 |
The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam.
Topics: Adult; Diazepam; Drug Interactions; Fluoxetine; Humans; Male; Middle Aged; Nordazepam; Propylamines; Psychomotor Performance | 1988 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Improved method for the determination of diazepam and N-desmethyldiazepam in plasma using capillary gas chromatography and nitrogen-phosphorus detection.
Topics: Chromatography, Gas; Diazepam; Humans; Nitrogen; Nordazepam; Phosphorus; Solvents | 1988 |
Sensitive determination of diazepam and N-desmethyldiazepam in human material using capillary gas chromatography-mass spectrometry.
Topics: Aged; Aged, 80 and over; Diazepam; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Male; Muscles; Nordazepam | 1988 |
[Effect of sodium valproate on brain levels of diazepam and N-desmethyldiazepam in the rat].
Topics: Animals; Brain Chemistry; Diazepam; Male; Nordazepam; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Mice; Mice, Inbred C3H; Nordazepam; Oxazepam; Pentylenetetrazole; Seizures; Species Specificity; Time Factors | 1985 |
Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations.
Topics: Adult; Aged; Aging; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedatives; Male; Nordazepam; Posture; Protein Binding; Psychomotor Performance | 1985 |
Liquid-chromatographic assay of diazepam and its major metabolites in serum, and application to pharmacokinetic study of high doses of diazepam in schizophrenics.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Diazepam; Female; Humans; Kinetics; Nordazepam; Oxazepam; Schizophrenia; Temazepam | 1985 |
Severe withdrawal syndrome after substitution of a short-acting benzodiazepine for a long-acting benzodiazepine.
Topics: Diazepam; Female; Half-Life; Humans; Middle Aged; Nordazepam; Oxazepam; Substance Withdrawal Syndrome | 1985 |
Development of tolerance to the anticonvulsant effect of diazepam in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Drug Tolerance; Electric Stimulation; Female; Kindling, Neurologic; Kinetics; Nordazepam; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro.
Topics: Adult; Benzimidazoles; Coumarins; Diazepam; Drug Interactions; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nordazepam; Omeprazole; Oxidation-Reduction; Phenytoin | 1985 |
N-desmethyldiazepam physical dependence in dogs.
Topics: Analysis of Variance; Animals; Body Weight; Diazepam; Dogs; Drinking; Energy Intake; Female; Lorazepam; Muscle Spasticity; Nordazepam; Oxazepam; Paresthesia; Substance Withdrawal Syndrome; Temazepam; Time Factors | 1985 |
Plasma concentrations of diazepam and N-desmethyldiazepam in Asian children after an intravenous or rectal dose of diazepam.
Topics: Child; Child, Preschool; Diazepam; Female; Humans; Injections, Intravenous; Male; Nordazepam; Rectum | 1985 |
Monitoring clorazepate dipotassium as desmethyldiazepam in plasma by electron-capture gas--liquid chromatography.
Topics: Anti-Anxiety Agents; Chromatography, Gas; Clorazepate Dipotassium; Diazepam; Dose-Response Relationship, Drug; Humans; Nordazepam | 1980 |
Determination of some benzodiazepines and metabolites in serum, urine and saliva by high-performance liquid chromatography.
Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Humans; Mathematics; Nordazepam; Oxazepam; Saliva; Temazepam | 1980 |
The psychosedative effect of chlordesmethyldiazepam on anxiety states in neurotic and psychotic inpatients.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Diazepam; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Neurotic Disorders; Nordazepam; Psychiatric Status Rating Scales; Psychotic Disorders; Reaction Time | 1980 |
[Pharmacokinetic of benzodiazepines in old age].
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Half-Life; Humans; Lorazepam; Metabolic Clearance Rate; Middle Aged; Nitrazepam; Nordazepam; Oxazepam | 1981 |
Aspects of the interaction of thyroxine and its binding serum proteins with 1,4-benzodiazepine tranquillizers.
Topics: Anti-Anxiety Agents; Autoradiography; Binding, Competitive; Chlordiazepoxide; Diazepam; Electrophoresis, Polyacrylamide Gel; Humans; Male; Nordazepam; Oxazepam; Temazepam; Thyroxine; Thyroxine-Binding Proteins | 1981 |
Studies on some pharmacological activities of 7-nitro-2-amino-5-phenyl-3H-1,5-benzodiazepine (CP 1414 S) in the rat. A comparison with diazepam.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Brain Chemistry; Conflict, Psychological; Diazepam; Female; Kinetics; Motor Activity; Nordazepam; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1981 |
Pharmacokinetics of N-desmethyldiazepam after a single oral dose of clorazepate: the effect of smoking.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazepam; Humans; Kinetics; Male; Nordazepam; Smoking | 1981 |
Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate.
Topics: Adult; Age Factors; Aged; Anti-Anxiety Agents; Biotransformation; Clorazepate Dipotassium; Diazepam; Female; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Nordazepam; Sex Factors | 1981 |
Does ethyl-beta-carboline-3-carboxylate interact with mouse brain benzodiazepine receptors in vivo?
Topics: Animals; Binding, Competitive; Brain; Carbolines; Diazepam; Indoles; Mice; Nordazepam; Receptors, Drug; Receptors, GABA-A | 1982 |
[Anxiolytics in man: studies on sleep and performance (author's transl)].
Topics: Anti-Anxiety Agents; Anxiety Disorders; Arousal; Attention; Benzodiazepines; Benzodiazepinones; Clobazam; Clorazepate Dipotassium; Diazepam; Dose-Response Relationship, Drug; Humans; Motor Skills; Nordazepam; Sleep Stages; Visual Perception | 1982 |
Some behavioral effects of chlorodesmethyldiazepam and lorazepam.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Diazepam; Humans; Lorazepam; Male; Mice; Nordazepam; Rats; Seizures | 1981 |
Rapid gas chromatographic measurement of diazepam and its metabolites desmethyldiazepam, oxazepam, and 3-hydroxydiazepam (temazepam) in small samples of plasma.
Topics: Anti-Anxiety Agents; Biotransformation; Chromatography, Gas; Diazepam; Humans; Nordazepam; Oxazepam; Temazepam | 1982 |
Determination of peptidoaminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) and its metabolites in human plasma by glass capillary gas chromatography negative ion chemical ionization mass spectrometry--1.
Topics: Anti-Anxiety Agents; Benzodiazepines; Diazepam; Gas Chromatography-Mass Spectrometry; Glycine; Humans; Lorazepam; Nordazepam | 1982 |
Does chlordesmethyldiazepam have a specific anti-erotic effect? Report on five observations.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Therapy, Combination; Female; Humans; Libido; Male; Middle Aged; Neurotic Disorders; Nordazepam | 1982 |
High-performance liquid chromatography determination of dipotassium clorazepate and its major metabolite nordiazepam in plasma.
Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Clorazepate Dipotassium; Diazepam; Dogs; Half-Life; Humans; Kinetics; Nordazepam | 1983 |
Pharmacokinetics of benzodiazepines and psychostimulants in children.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Attention Deficit Disorder with Hyperactivity; Biotransformation; Child; Child Development; Child, Preschool; Diazepam; Epilepsy; Female; Half-Life; Humans; Infant; Infant, Newborn; Kinetics; Male; Methylphenidate; Nordazepam | 1983 |
Clorazepate dipotassium and diazepam in renal insufficiency: serum concentrations and protein binding of diazepam and desmethyldiazepam.
Topics: Adult; Aged; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Nordazepam; Protein Binding | 1984 |
[Pharmacokinetics and metabolite pattern of tetrazepam and chlordesmethyldiazepam].
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Biotransformation; Diazepam; Humans; Kinetics; Male; Nordazepam | 1984 |
Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Female; Humans; Labor, Obstetric; Maternal-Fetal Exchange; Milk, Human; Nordazepam; Placenta; Pregnancy | 1984 |
Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clorazepate Dipotassium; Diazepam; Female; Humans; Kinetics; Male; Molecular Weight; Nordazepam; Prazepam | 1984 |
Antiepileptic effect and serum levels of clorazepate on children with refractory seizures.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Clorazepate Dipotassium; Diazepam; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Infant; Nordazepam; Spasms, Infantile | 1984 |
Value of serum diazepam and nordiazepam measurements in anxious patients.
Topics: Adult; Aged; Anxiety Disorders; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nordazepam; Patient Compliance; Time Factors | 1984 |
Blood concentrations of diazepam and its metabolites in children and neonates with tetanus.
Topics: Child; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Nordazepam; Oxazepam; Tetanus | 1983 |
Diazepam kinetics in patients with severe burns.
Topics: Adult; Aged; Burns; Diazepam; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Nordazepam | 1983 |
Repeated diazepam dosing in cirrhotic patients: cumulation and sedation.
Topics: Adult; Diazepam; Half-Life; Humans; Hypnotics and Sedatives; Kinetics; Liver Cirrhosis; Male; Middle Aged; Nordazepam | 1983 |
The role of buffer composition during equilibrium dialysis in determining concentrations of free diazepam in serum.
Topics: Buffers; Dialysis; Diazepam; Humans; Male; Nordazepam; Protein Binding | 1983 |
Differences in in vitro binding of diazepam and N-desmethyldiazepam to maternal and fetal plasma proteins at birth: relation to free fatty acid concentration and other parameters.
Topics: Adolescent; Adult; Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Fetal Blood; Humans; Infant, Newborn; Labor, Obstetric; Middle Aged; Nordazepam; Pregnancy; Protein Binding | 1983 |
Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chromatography, Gas; Diazepam; Humans; Kinetics; Nordazepam | 1983 |
Metabolic and pharmacological studies with N-methyl-N'-methyl-2'-allyl-2-benzoyl-4-chloro-glycinanilide (F 1797).
Topics: Anilides; Animals; Anticonvulsants; Brain Chemistry; Diazepam; Male; Nordazepam; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1983 |
Pharmacokinetic model for diazepam and its major metabolite desmethyldiazepam following diazepam administration.
Topics: Adult; Clorazepate Dipotassium; Diazepam; Humans; Kinetics; Male; Models, Biological; Nordazepam | 1983 |
Multiple-dose pharmacokinetics of diazepam following once-daily administration of a controlled-release capsule.
Topics: Adult; Biological Availability; Delayed-Action Preparations; Diazepam; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Nordazepam | 1983 |
Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.
Topics: Adult; Bilirubin; Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Fetal Blood; Humans; Infant, Newborn; Nordazepam; Pregnancy; Protein Binding; Serum Albumin | 1984 |
Pharmacokinetics of diazepam and nordiazepam in the cat.
Topics: Animals; Cats; Diazepam; Female; Injections, Intravenous; Kinetics; Liver Circulation; Nordazepam; Time Factors | 1984 |
Diazepam and desmethyldiazepam plasma concentrations in chronic anxious outpatients.
Topics: Adult; Anxiety Disorders; Chronic Disease; Diazepam; Female; Humans; Male; Middle Aged; Nordazepam | 1984 |
Serum protein binding of diazepam, desmethyldiazepam, furosemide, indomethacin, warfarin, and phenobarbital in human fetus, mother, and newborn infant.
Topics: Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Fetal Blood; Furosemide; Humans; Indomethacin; Infant, Newborn; Maternal-Fetal Exchange; Nordazepam; Phenobarbital; Pregnancy; Protein Binding; Warfarin | 1983 |
In vitro interaction of diazepam and oxazepam with pancuronium and suxamethonium.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Muscle Contraction; Neuromuscular Junction; Nordazepam; Oxazepam; Pancuronium; Rats; Rats, Inbred Strains; Succinylcholine; Temazepam | 1984 |
Propranolol interactions with diazepam, lorazepam, and alprazolam.
Topics: Adolescent; Adult; Alprazolam; Benzodiazepines; Biotransformation; Chromatography, High Pressure Liquid; Diazepam; Drug Interactions; Female; Humans; Injections, Intravenous; Kinetics; Lorazepam; Male; Nordazepam; Propranolol | 1984 |
Diazepam tapering in detoxification for high-dose benzodiazepine abuse.
Topics: Adult; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Inactivation, Metabolic; Kinetics; Male; Mental Status Schedule; Middle Aged; Nordazepam; Prospective Studies; Substance-Related Disorders | 1984 |
Subcellular distribution of pinazepam and its metabolite N-desmethyldiazepam in rat liver.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Cell Nucleus; Cytosol; Diazepam; Liver; Male; Microsomes, Liver; Nordazepam; Rats; Rats, Inbred Strains; Subcellular Fractions | 1984 |
Development of tolerance to the anticonvulsant effect of diazepam in dogs.
Topics: Animals; Anticonvulsants; Diazepam; Dogs; Drug Tolerance; Electrocardiography; Electroencephalography; Female; Male; Nordazepam; Pentylenetetrazole; Seizures; Time Factors | 1984 |
Elimination kinetics and symptomatology of diazepam withdrawal in abusers.
Topics: Diazepam; Half-Life; Humans; Kinetics; Nordazepam; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
The contribution of the active metabolites to the tolerance developing to diazepam in man: relationship to bioassayed serum benzodiazepine levels.
Topics: Adult; Benzodiazepines; Biological Assay; Diazepam; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Nordazepam; Oxazepam; Psychomotor Performance | 1984 |
Diazepam and N-desmethyldiazepam redistribution after heparin.
Topics: Adult; Biotransformation; Blood Proteins; Diazepam; Drug Interactions; Heparin; Humans; Male; Nordazepam; Protein Binding | 1980 |
Diurnal variations in plasma diazepam concentrations associated with reciprocal changes in free fraction.
Topics: Adolescent; Adult; Circadian Rhythm; Diazepam; Female; Food; Humans; Injections, Intravenous; Male; Nordazepam; Time Factors | 1980 |
Delayed clearance of diazepam due to cimetidine.
Topics: Adult; Antipyrine; Cimetidine; Diazepam; Drug Interactions; Drug Synergism; Female; Guanidines; Half-Life; Humans; Kinetics; Male; Nordazepam | 1980 |
Diazepam and N-desmethyldiazepam concentrations in saliva, plasma and CSF.
Topics: Adult; Diazepam; Female; Humans; Hydrogen-Ion Concentration; Male; Nordazepam; Protein Binding; Saliva; Time Factors | 1980 |
Desmethyldiazepam kinetics in the elderly after oral prazepam.
Topics: Adult; Age Factors; Aged; Blood Proteins; Diazepam; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Nordazepam; Prazepam; Protein Binding; Regression Analysis; Sex Factors; Smoking | 1980 |
Comparative effects of two commercially available blood collection tubes on plasma concentrations of drugs.
Topics: Acebutolol; Blood Specimen Collection; Carbamazepine; Diazepam; Digoxin; Ethosuximide; Humans; Nordazepam; Penbutolol; Pharmaceutical Preparations; Propranolol; Quinidine; Salicylates; Time Factors; Valproic Acid; Warfarin | 1980 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacaine; Mice; Nitrazepam; Nordazepam; Oxazepam; Prilocaine; Seizures; Structure-Activity Relationship; Temazepam | 1980 |
Effect of diazepam and desmethyldiazepam in spasticity and rigidity. A quantitative study of reflexes and plasma concentrations.
Topics: Adult; Diazepam; Female; Humans; Injections, Intravenous; Male; Middle Aged; Muscle Rigidity; Muscle Spasticity; Muscle Tonus; Nordazepam; Reflex | 1980 |
Simultaneous assay of diazepam, chlordiazepoxide, N-desmethyldiazepam, N-desmethylchloridazepoxide, and demoxepam in serum by high performance, liquid chromatography.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Chromatography, High Pressure Liquid; Diazepam; Humans; Methods; Nordazepam | 1980 |
Entry of diazepam and its major matabolite into cerebrospinal fluid.
Topics: Animals; Blood Proteins; Diazepam; Dogs; Nordazepam; Protein Binding | 1980 |
High-performance liquid chromatographic and gas-liquid chromatographic determination of diazepam and nordiazepam in plasma.
Topics: Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Diazepam; Humans; Male; Nordazepam; Status Epilepticus | 1980 |
Evaluation of an enzyme immunoassay for determining diazepam and nordiazepam in serum and urine.
Topics: Chromatography, High Pressure Liquid; Depression; Diazepam; Evaluation Studies as Topic; Humans; Immunoenzyme Techniques; Nordazepam | 1980 |
Pharmacological requirements of patients during alcohol withdrawal.
Topics: Alcoholism; Diazepam; Ethanol; Humans; Nordazepam | 1981 |
The effect of diazepam on rates of fertilization in the CF-1 mouse.
Topics: Animals; Chorionic Gonadotropin; Chromatin; Copulation; Diazepam; Female; Fertilization; Meiosis; Mice; Mice, Inbred Strains; Nordazepam; Ovum; Superovulation | 1981 |
Influence of cimetidine on the pharmacokinetics of desmethyldiazepam and oxazepam.
Topics: Adult; Cimetidine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Humans; Kinetics; Liver; Male; Nordazepam; Oxazepam | 1980 |
Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy.
Topics: Adult; Aged; Diazepam; Humans; Male; Middle Aged; Nordazepam; Time Factors | 1981 |
Effects of desmethyldiazepam on diazepam kinetics: a study of effects of a metabolite on parent drug disposition.
Topics: Adult; Diazepam; Female; Humans; Kinetics; Male; Nordazepam | 1981 |
Benzodiazepine overdosage: plasma concentrations and clinical outcome.
Topics: Adolescent; Adult; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Male; Middle Aged; Nordazepam | 1981 |
[Plasma levels following high diazepam doses in intensive-care medicine (author's transl)].
Topics: Adult; Critical Care; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nordazepam | 1981 |
Long-term use of diazepam.
Topics: Adult; Aged; Diazepam; Female; Humans; Kinetics; Male; Middle Aged; Muscle Cramp; Nordazepam; Pain; Substance-Related Disorders; Time Factors | 1981 |
Effect of ethanol ingestion on outcome of drug overdose.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Barbiturates; Benzodiazepines; Coma; Diazepam; Drug Interactions; Ethanol; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Nordazepam; Phenothiazines; Poisoning; Salicylates; Suicide, Attempted | 1982 |
Valproic acid and diazepam interaction in vivo.
Topics: Adult; Blood Proteins; Diazepam; Drug Interactions; Humans; Kinetics; Male; Nordazepam; Protein Binding; Valproic Acid | 1982 |
Binding of diazepam and desmethyldiazepam to plasma protein: concentration-dependence and interactions.
Topics: Binding, Competitive; Blood Proteins; Dialysis; Diazepam; Humans; In Vitro Techniques; Nordazepam; Protein Binding | 1981 |
Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration.
Topics: Adult; Diazepam; Epilepsy; Half-Life; Humans; Injections, Intravenous; Male; Nordazepam | 1981 |
Clinical bioavailability evaluation of a controlled release formulation of diazepam.
Topics: Adult; Biological Availability; Biopharmaceutics; Delayed-Action Preparations; Diazepam; Humans; Nordazepam; Time Factors | 1981 |
Radioimmunoassay of benzodiazepines.
Topics: Benzodiazepines; Chlordiazepoxide; Clonazepam; Diazepam; Flurazepam; Humans; Microchemistry; Nitrazepam; Nordazepam; Oxazepam; Radioimmunoassay | 1982 |
Kinetics of high-dose i.v. diazepam.
Topics: Adult; Critical Care; Diazepam; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Nordazepam | 1982 |
Pinazepam: a precursor of N-desmethyldiazepam.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Half-Life; Humans; Kinetics; Male; Nordazepam | 1982 |
Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate).
Topics: Adult; Aged; Body Weight; Clorazepate Dipotassium; Diazepam; Female; Half-Life; Humans; Male; Middle Aged; Nordazepam; Obesity | 1982 |
Sensitivity of auditory lateralization and temporal order tests to benzodiazepines.
Topics: Adult; Anti-Anxiety Agents; Auditory Pathways; Benzodiazepines; Diazepam; Ear; Functional Laterality; Hearing Tests; Humans; Loudness Perception; Middle Aged; Nordazepam; Sound Localization; Time Factors | 1982 |
Anticonvulsant potency of unmetabolized diazepam.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Male; Mice; Nordazepam; Oxazepam; Pentylenetetrazole; Time Factors | 1982 |
Chronic diazepam treatment in psychiatric outpatients.
Topics: Adult; Aged; Ambulatory Care; Anxiety Disorders; Chronic Disease; Diazepam; Humans; Male; Middle Aged; Nordazepam; Psychiatric Status Rating Scales | 1982 |
Correlation of the bioavailability of diazepam from uncoated tablets in beagle dogs with its dissolution rate and bioavailability in humans.
Topics: Animals; Biological Availability; Body Weight; Diazepam; Dogs; Humans; Hydrogen-Ion Concentration; Nordazepam; Solubility; Species Specificity; Tablets | 1982 |
[The distribution of drugs between plasma, brain and cerebrospinal fluid in the human].
Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Carbamazepine; Diazepam; Humans; Lithium; Nordazepam; Phenobarbital; Phenytoin; Primidone; Protein Binding; Psychotropic Drugs; Serum Albumin; Sulfamerazine | 1982 |
Acid-base equilibria of 1,4-benzodiazepine 4-oxides by spectrophotometry.
Topics: Chemical Phenomena; Chemistry, Physical; Chlordiazepoxide; Diazepam; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Nordazepam; Spectrophotometry, Ultraviolet | 1995 |
Development and preliminary application of high-performance liquid chromatographic assay of urinary metabolites of diazepam in humans.
Topics: Chromatography, High Pressure Liquid; Diazepam; Humans; Nordazepam; Oxazepam; Reference Values; Reproducibility of Results; Temazepam | 1995 |
Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
Topics: Animals; Anti-Anxiety Agents; Antidotes; Biological Availability; Delayed-Action Preparations; Diazepam; Drug Implants; Female; Flumazenil; Flunitrazepam; Nordazepam; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Behavioral and metabolic consequences of neonatal exposure to diazepam in rat pups.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Diazepam; Glucose; Locomotion; Nordazepam; Postural Balance; Posture; Rats | 1995 |
Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.
Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diazepam; Humans; In Vitro Techniques; Isoenzymes; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Nordazepam; Temazepam | 1994 |
Relationship between plasma benzodiazepine receptor ligand concentrations and severity of hepatic encephalopathy.
Topics: Adult; Benzodiazepines; Diazepam; Female; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; Ligands; Male; Nordazepam; Prognosis; Receptors, GABA-A | 1994 |
Inhibitory effect of diltiazem on diazepam metabolism in the mouse hepatic microsomes.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Diltiazem; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Nordazepam; Oxidoreductases, N-Demethylating | 1993 |
Determination of plasma diazepam and desmethyldiazepam by solid-phase extraction and reversed-phase high-performance liquid chromatography.
Topics: Calibration; Chromatography, High Pressure Liquid; Diazepam; Humans; Nordazepam; Reference Standards; Spectrophotometry, Ultraviolet | 1993 |
Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs.
Topics: Administration, Oral; Animals; Blood Proteins; Diazepam; Dogs; Female; Flumazenil; Hydrolysis; Injections, Intravenous; Nordazepam; Oxazepam; Protein Binding; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver.
Topics: Animals; Diazepam; Kinetics; Male; Mice; Microsomes, Liver; Nordazepam; Oxazepam; Perfusion | 1993 |
Extraction of selected drugs from serum using microwave irradiation.
Topics: Analgesics; Blood Chemical Analysis; Chromatography, Gas; Dextropropoxyphene; Diazepam; Humans; Lidocaine; Methadone; Microwaves; Narcotics; Nordazepam; Retrospective Studies | 1996 |
Assessment of diazepam loading dose therapy of delirium tremens.
Topics: Adult; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Neurologic Examination; Nordazepam; Psychoses, Alcoholic; Treatment Outcome | 1996 |
Flumazenil, diazepam, nordiazepam and oxazepam interactions on plasma protein binding.
Topics: Animals; Anti-Anxiety Agents; Biotransformation; Blood Proteins; Diazepam; Dogs; Drug Interactions; Flumazenil; In Vitro Techniques; Nordazepam; Oxazepam; Protein Binding | 1995 |
Lymphatic bioavailability of diazepam and desmethyldiazepam in the rat.
Topics: Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Chromatography, Gas; Diazepam; Duodenum; GABA Modulators; Infusions, Intravenous; Injections; Injections, Intravenous; Lipid Metabolism; Lymph; Lymphatic System; Nordazepam; Rats | 1996 |
Evidence against oppositional and pharmacokinetic mechanisms of tolerance to diazepam's sedative effects.
Topics: Animals; Diazepam; Drug Tolerance; Hypnotics and Sedatives; Male; Motor Activity; Nordazepam; Osmolar Concentration; Rats; Rats, Inbred Strains; Time Factors | 1996 |
Benzodiazepine misuse by drug addicts.
Topics: Alcoholism; Benzodiazepines; Chromatography, High Pressure Liquid; Diazepam; Humans; Narcotics; Nitrazepam; Nordazepam; Substance-Related Disorders; Temazepam | 1997 |
[Benzodiazepines in geriatrics--a case report on prolonged action].
Topics: Aged; Anti-Anxiety Agents; Dementia; Diazepam; Diverticulitis, Colonic; Drug Therapy, Combination; Emergencies; Female; Humans; Intestinal Perforation; Metabolic Clearance Rate; Nordazepam; Postoperative Complications | 1996 |
Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Bundle-Branch Block; Diagnosis, Differential; Diazepam; Electrocardiography; Female; Heart Ventricles; Humans; Hypnotics and Sedatives; Long QT Syndrome; Maprotiline; Myocardial Infarction; Nordazepam; Perphenazine; Triazolam | 1997 |
Age-related changes in the pharmacokinetic disposition of diazepam in foals.
Topics: Adjuvants, Anesthesia; Aging; Animals; Diazepam; Female; Half-Life; Horses; Male; Metabolic Clearance Rate; Nordazepam | 1997 |
A fatality due to moclobemide.
Topics: Antidepressive Agents; Benzamides; Diazepam; Fatal Outcome; Female; Flumazenil; Humans; Liver; Middle Aged; Moclobemide; Nordazepam; Trifluoperazine | 1997 |
Application of microdialysis to study the in vitro metabolism of drugs in liver microsomes.
Topics: Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diazepam; Ibuprofen; Kinetics; Microdialysis; Microsomes, Liver; Nordazepam; Rats; Salicylates; Salicylic Acid; Temazepam | 1997 |
Benzodiazepine-like compounds in the plasma of patients with fulminant hepatic failure.
Topics: Adult; Benzodiazepines; Chromatography, High Pressure Liquid; Diazepam; Female; Hepatic Encephalopathy; Humans; Liver Failure; Male; Mass Spectrometry; Middle Aged; Nordazepam; Radioligand Assay | 1998 |
Comparison of single- and repeated-dose pharmacokinetics of diazepam.
Topics: Animals; Chromatography, High Pressure Liquid; Clinical Protocols; Diazepam; Dose-Response Relationship, Drug; Humans; Injections, Intraperitoneal; Male; Nordazepam; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1998 |
Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam.
Topics: Cytochrome P-450 Enzyme System; Diazepam; DNA, Complementary; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kinetics; Linear Models; Microsomes, Liver; Nordazepam; Temazepam | 1998 |
The effect of chronic benzodiazepines exposure on body weight in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; GABA Modulators; Male; Nordazepam; Oxazepam; Rats; Rats, Sprague-Dawley; Sex Factors; Time Factors; Weight Gain | 1998 |
Rapid and simple chromatographic method for the determination of diazepam and its major metabolites in human plasma and urine.
Topics: Calibration; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Humans; Nordazepam; Oxazepam; Reference Values; Temazepam | 1998 |
Determination of benzodiazepines in human urine and plasma with solvent modified solid phase micro extraction and gas chromatography; rationalisation of method development using experimental design strategies.
Topics: Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Chromatography, Gas; Diazepam; Flunitrazepam; Humans; Hydrogen-Ion Concentration; Models, Chemical; Nordazepam; Oxazepam; Research Design | 1998 |
Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.
Topics: Adult; Allosteric Regulation; Allosteric Site; Antibodies, Monoclonal; Catalysis; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Models, Chemical; Nordazepam; Oxidation-Reduction; Temazepam | 1999 |
Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects.
Topics: Adult; Anti-Anxiety Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diazepam; Gene Dosage; Half-Life; Heterozygote; Homozygote; Humans; Male; Mixed Function Oxygenases; Nordazepam; Phenotype; Reference Values | 1999 |
Fatal intoxication with melperone.
Topics: Adult; Anti-Anxiety Agents; Antimanic Agents; Antipsychotic Agents; Autopsy; Butyrophenones; Carbamazepine; Cause of Death; Diazepam; Drug Synergism; Fatal Outcome; Female; Homicide; Humans; Nordazepam; Substance Abuse Detection; Suicide | 2000 |
Liquid-phase microextraction as a sample preparation technique prior to capillary gas chromatographic-determination of benzodiazepines in biological matrices.
Topics: Chromatography, Gas; Diazepam; Humans; Nordazepam; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Diazepam poisoning with one-month monitoring of diazepam and nordiazepam blood levels.
Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Flumazenil; Humans; Male; Middle Aged; Nordazepam; Poisoning; Suicide, Attempted; Treatment Outcome | 2001 |
The simultaneous determination of diazepam and its three metabolites in dog plasma by high-performance liquid chromatography with mass spectroscopy detection.
Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Diazepam; Dogs; Mass Spectrometry; Nordazepam; Oxazepam; Reproducibility of Results; Temazepam | 2001 |
A contemporaneous finding of fenproporex in a polydrug suicide.
Topics: Adult; Amphetamines; Anti-Allergic Agents; Anticonvulsants; Appetite Depressants; Autopsy; Diazepam; Diphenhydramine; Drug Overdose; Female; Humans; Hydroxybutyrates; Nordazepam; Stomach; Suicide | 2001 |
Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys.
Topics: Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Diazepam; Discrimination Learning; GABA Modulators; GABA-A Receptor Agonists; Imidazoles; Injections, Intramuscular; Injections, Intravenous; Male; Midazolam; Nordazepam; Reinforcement, Psychology; Saimiri; Self Administration | 2003 |
Effects of diazepam and its metabolites on nocturnal melatonin secretion in the rat pineal and Harderian glands. A comparative in vivo and in vitro study.
Topics: Animals; Circadian Rhythm; Diazepam; Harderian Gland; In Vitro Techniques; Male; Melatonin; Nordazepam; Oxazepam; Perfusion; Pineal Gland; Rats; Rats, Wistar; Temazepam | 2003 |
Coexistence and concentrations of ethanol and diazepam in postmortem blood specimens: risk for enhanced toxicity?
Topics: Central Nervous System Depressants; Chromatography, Gas; Diazepam; Drug Interactions; Ethanol; Forensic Medicine; GABA Modulators; Humans; Nordazepam; Risk Factors | 2003 |
High concentrations of diazepam and nordiazepam in blood of impaired drivers: association with age, gender and spectrum of other drugs present.
Topics: Adolescent; Adult; Age Distribution; Amphetamine; Anti-Anxiety Agents; Automobile Driving; Central Nervous System Depressants; Central Nervous System Stimulants; Databases as Topic; Diazepam; Dronabinol; Ethanol; Female; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Hypnotics and Sedatives; Male; Middle Aged; Morphine; Narcotics; Nordazepam; Sex Distribution; Substance Abuse Detection; Substance-Related Disorders; Sweden | 2004 |
Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the quantitation of prazepam and its main metabolites in human plasma.
Topics: Calibration; Chromatography, Liquid; Diazepam; Humans; Molecular Structure; Nordazepam; Oxazepam; Prazepam; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Fast in vivo microextraction: a new tool for clinical analysis.
Topics: Animals; Biocompatible Materials; Blood Chemical Analysis; Blood Specimen Collection; Calibration; Chemistry Techniques, Analytical; Chromatography, Liquid; Diazepam; Dogs; Mass Spectrometry; Nordazepam; Oxazepam; Polyethylene Glycols; Polymers; Pyrroles; Silicon Dioxide | 2006 |
Medicolegal aspects of tetrazepam metabolism.
Topics: Adult; Benzodiazepines; Diazepam; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Male; Molecular Structure; Muscle Relaxants, Central; Nordazepam | 2007 |
A sensitive and selective method for the detection of diazepam and its main metabolites in urine by gas chromatography-tandem mass spectrometry.
Topics: Benzodiazepinones; Diazepam; Gas Chromatography-Mass Spectrometry; Nordazepam; Oxazepam; Reproducibility of Results; Tandem Mass Spectrometry; Time Factors | 2007 |
Massive intoxication involving unusual high concentration of amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Diazepam; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Nordazepam; Nortriptyline; Spectrometry, Mass, Electrospray Ionization; Suicide | 2007 |
Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes.
Topics: Anti-Inflammatory Agents; Antithyroid Agents; Biotransformation; Cell Separation; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dexamethasone; Diazepam; Enzyme Induction; Hepatocytes; Humans; Hypnotics and Sedatives; Models, Biological; Models, Statistical; Nordazepam; Organ Culture Techniques; Oxazepam; Phenobarbital; Temazepam | 2009 |
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin; Drug Overdose; Female; Heroin Dependence; Humans; Hydrocodone; Malpractice; Methadone; Nordazepam; Pain; Pain Measurement; Practice Guidelines as Topic; Shoulder; Shoulder Injuries; Temazepam | 2009 |
Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Nordazepam; Oxazepam; Rats; Reproducibility of Results; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Temazepam | 2009 |
Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam.
Topics: Acetonitriles; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diazepam; Dimethyl Sulfoxide; GABA Modulators; Humans; Kinetics; Methanol; Microsomes, Liver; Nordazepam; Solvents; Temazepam | 2010 |
Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS).
Topics: Alprazolam; Benzodiazepines; Diazepam; Gas Chromatography-Mass Spectrometry; Humans; Lorazepam; Nordazepam; Oxazepam; Solid Phase Extraction; Triazolam | 2010 |
Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes.
Topics: Adult; Animals; Bioreactors; Biotransformation; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Diazepam; Female; Hepatocytes; Humans; Inactivation, Metabolic; Liver, Artificial; Male; Nordazepam; Oxazepam; Swine; Temazepam; Young Adult | 2011 |
Reduction of temazepam to diazepam and lorazepam to delorazepam during enzymatic hydrolysis.
Topics: Benzodiazepines; Chromatography, Liquid; Diazepam; Glucuronidase; Humans; Hydrolysis; Lorazepam; Mass Spectrometry; Nordazepam; Reference Standards; Temazepam | 2011 |
Pharmacokinetics of the cytochrome P-450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diazepam; Dogs; Female; Fluorescence Polarization Immunoassay; Gas Chromatography-Mass Spectrometry; Injections, Intravenous; Male; Nordazepam; Oxazepam; Phenytoin; Theophylline | 2012 |
Concentrations of diazepam and nordiazepam in 1,000 blood samples from apprehended drivers--therapeutic use or abuse of anxiolytics?
Topics: Automobile Driving; Chromatography, Gas; Databases, Factual; Diazepam; Forensic Toxicology; Humans; Limit of Detection; Nordazepam; Prescription Drug Misuse; Substance Abuse Detection | 2013 |
The potential of forensic analysis on human bones found in riverine environment.
Topics: Adult; Animals; Bone and Bones; Diatoms; Diazepam; DNA Fingerprinting; Feeding Behavior; Forensic Anthropology; Forensic Toxicology; Humans; Hypnotics and Sedatives; Male; Muscidae; Nordazepam; Postmortem Changes; Pupa; Rivers; Young Adult | 2013 |
Concentrations of drugs determined in blood samples collected from suspected drugged drivers in England and Wales.
Topics: Adolescent; Adult; Amphetamine; Automobile Driving; Central Nervous System Depressants; Chromatography, Liquid; Cocaine; Diazepam; England; Ethanol; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Male; Methadone; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Nordazepam; Sodium Oxybate; Substance Abuse Detection; Substance-Related Disorders; Wales; Young Adult | 2013 |
Diazepam and its metabolites in the mothers' and newborns' hair as a biomarker of prenatal exposure.
Topics: Biomarkers; Chromatography, Liquid; Diazepam; Female; Hair; Humans; Infant, Newborn; Maternal-Fetal Exchange; Mothers; Nordazepam; Pregnancy; Pregnancy Trimesters; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Direct determination of diazepam and its glucuronide metabolites in human whole blood by μElution solid-phase extraction and liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Diazepam; Forensic Toxicology; Humans; Hypnotics and Sedatives; Limit of Detection; Nordazepam; Oxazepam; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Temazepam | 2013 |
Urinary diazepam metabolite distribution in a chronic pain population.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chronic Pain; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diazepam; Drug Interactions; Esomeprazole; Female; Fluoxetine; Humans; Male; Methadone; Nordazepam; Oxazepam; Retrospective Studies; Specimen Handling; Temazepam | 2014 |
A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case.
Topics: Adult; Alprazolam; Benzodiazepines; Benzodioxoles; Chlordiazepoxide; Chromatography, Liquid; Diazepam; Humans; Hypnotics and Sedatives; Male; Mass Spectrometry; Nordazepam; Oxazepam; Psychotropic Drugs; Pyrrolidines; Substance-Related Disorders; Synthetic Cathinone; Temazepam | 2014 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; Electroencephalography; Epilepsy, Temporal Lobe; Ethanol; Female; Kainic Acid; Mice; Nordazepam; Oxazepam; Seizures; Solvents; Temazepam; Water | 2014 |
A comparative study of primary secondary amino (PSA) and multi-walled carbon nanotubes (MWCNTs) as QuEChERS absorbents for the rapid determination of diazepam and its major metabolites in fish samples by high-performance liquid chromatography-electrospray
Topics: Adsorption; Animals; Chromatography, High Pressure Liquid; Diazepam; Fishes; Food Contamination; Nanotubes, Carbon; Nordazepam; Oxazepam; Seafood; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temazepam | 2016 |
Preparation of a novel sorptive stir bar based on vinylpyrrolidone-ethylene glycol dimethacrylate monolithic polymer for the simultaneous extraction of diazepam and nordazepam from human plasma.
Topics: Adsorption; Chromatography, High Pressure Liquid; Diazepam; Humans; Methacrylates; Nordazepam; Polymerization; Pyrrolidinones; Surface Properties | 2016 |
Characterization of equine cytochrome P450: role of CYP3A in the metabolism of diazepam.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP3A; Diazepam; Horses; Hypnotics and Sedatives; Male; Microsomes, Liver; Nordazepam; Oxazepam; Phylogeny; Protein Isoforms; Rats; Rats, Sprague-Dawley; Species Specificity; Temazepam | 2016 |
Deposition of diazepam and its metabolites in hair following a single dose of diazepam.
Topics: Adult; Asian People; Chromatography, Liquid; Diazepam; Female; Hair; Healthy Volunteers; Humans; Hypnotics and Sedatives; Male; Nordazepam; Oxazepam; Tandem Mass Spectrometry; Temazepam; Young Adult | 2017 |
Pentobarbital in the context of possible suicides: Analysis of a Case.
Topics: Adult; Central Nervous System Depressants; Diazepam; Ethanol; Gastrointestinal Contents; Humans; Male; Nordazepam; Oxazepam; Pentobarbital; Suicide; Temazepam | 2017 |
Site-, Technique-, and Time-Related Aspects of the Postmortem Redistribution of Diazepam, Methadone, Morphine, and their Metabolites: Interest of Popliteal Vein Blood Sampling.
Topics: Adult; Blood Specimen Collection; Chromatography, Liquid; Diazepam; Female; Femoral Vein; Forensic Toxicology; Humans; Male; Methadone; Middle Aged; Morphine; Morphine Derivatives; Nordazepam; Oxazepam; Popliteal Vein; Postmortem Changes; Subclavian Vein; Young Adult | 2017 |
Occurrence of diazepam and its metabolites in wastewater and surface waters in Beijing.
Topics: Beijing; Cities; Diazepam; Nordazepam; Wastewater; Water Pollutants, Chemical | 2017 |
Entomotoxicology in burnt bodies: a case of maternal filicide-suicide by fire.
Topics: Adult; Animals; Automobiles; Burns; Carbon Monoxide Poisoning; Carboxyhemoglobin; Child; Child, Preschool; Diazepam; Diptera; Feeding Behavior; Female; Fires; Gasoline; Homicide; Humans; Hypnotics and Sedatives; Kidney; Larva; Liver; Male; Nordazepam; Oxazepam; Postmortem Changes; Suicide | 2017 |
Acidic transformation of nordiazepam can affect recovery estimate during trace analysis of diazepam and nordiazepam in environmental water samples by liquid chromatography-tandem mass spectrometry.
Topics: Acids; Chromatography, Liquid; Diazepam; Hydrogen-Ion Concentration; Limit of Detection; Nordazepam; Solid Phase Extraction; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2019 |
Validation of an LC-MS/MS Method for the Quantification of 13 Designer Benzodiazepines in Blood.
Topics: Benzodiazepines; Chromatography, Liquid; Diazepam; Humans; Nordazepam; Substance Abuse Detection; Tandem Mass Spectrometry | 2019 |
Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine.
Topics: Adult; Benzodiazepines; Bile; Body Fluids; Brain Chemistry; Designer Drugs; Diazepam; Forensic Toxicology; Gastrointestinal Contents; Humans; Kidney; Liver; Lorazepam; Lung; Male; Nordazepam; Pericardial Fluid; Phenmetrazine; Postmortem Changes; Psoas Muscles; Tandem Mass Spectrometry | 2019 |
An Experimental Pharmacokinetics Study of Diazepam and Its Metabolites in Oral Fluid of Chinese Population.
Topics: Adult; Chromatography, High Pressure Liquid; Diazepam; Healthy Volunteers; Humans; Nordazepam; Saliva; Solid Phase Extraction | 2020 |
Postmortem Analysis of Benzodiazepines in Human Bone by Gas Chromatography-Mass Spectrometry.
Topics: Alprazolam; Autopsy; Benzodiazepines; Chromatography, Liquid; Clonazepam; Diazepam; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Liquid-Liquid Extraction; Lorazepam; Nordazepam; Oxazepam; Tandem Mass Spectrometry | 2021 |
A case report on fatal intoxication by tapentadol: Study of distribution and metabolism.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Bile; Chromatography, Liquid; Diazepam; Dibenzothiazepines; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents; Hair; Humans; Male; Nordazepam; Prisoners; Tapentadol; Tranquilizing Agents; Valproic Acid | 2021 |
Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control.
Topics: Administration, Intravenous; Animals; Chromatography, Liquid; Diazepam; Doping in Sports; Horses; Nordazepam | 2021 |
TSDC and DSC Investigation on the Molecular Mobility in the Amorphous Solid State and in the Glass Transformation Region of Two Benzodiazepine Derivatives: Diazepam and Nordazepam.
Topics: Anti-Anxiety Agents; Calorimetry, Differential Scanning; Diazepam; Glass; Hypnotics and Sedatives; Nordazepam | 2022 |
Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Diazepam: Unbound Interstitial Brain Concentrations Correspond to Clinical End Points.
Topics: Benzodiazepines; Brain; Diazepam; gamma-Aminobutyric Acid; Humans; Nordazepam | 2022 |
Clinical Toxicological Follow-Up Analysis of a Suicide Attempt Using Chloroquine.
Topics: Chloroquine; Diazepam; Follow-Up Studies; Humans; Nordazepam; Suicide, Attempted | 2023 |
Occurrence of Z-drugs, benzodiazepines, and ketamine in wastewater in the United States and Mexico during the Covid-19 pandemic.
Topics: Alprazolam; Benzodiazepines; Clonazepam; COVID-19; Diazepam; Humans; Ketamine; Lorazepam; Mexico; Nordazepam; Pandemics; Tandem Mass Spectrometry; Temazepam; United States; Wastewater; Zolpidem | 2023 |