norcodeine and morphine

norcodeine has been researched along with morphine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.81)18.7374
1990's10 (37.04)18.2507
2000's6 (22.22)29.6817
2010's7 (25.93)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Avdeef, A; Barrett, DA; Davis, SS; Knaggs, RD; Shaw, PN1
Strassburg, CP; Tukey, RH1
Bellman, K; Knegtel, RM; Settimo, L1
Carroll, FI; Che, T; Huang, XP; Jin, J; Karpiak, J; Kroeze, WK; Lansu, K; Liu, J; McCorvy, JD; Nagase, H; Roth, BL; Shoichet, BK1
Yeh, SY1
Verwey-van Wissen, CP; Vree, TB1
Koopman-Kimenai, PM; Verwey-van Wissen, CP; Vree, TB1
Bochner, F; Chen, ZR; Somogyi, A2
Hanioka, N; Oguri, K; Yoshimura, H1
Ladona, MG; Meyer, UA; Mortimer, O; Persson, K; Rane, A; Spalding, D; Zanger, UM1
Lindström, B; Persson, K; Rane, A; Spalding, D; Wahlström, A1
Bodd, E; Drevon, CA; Kveseth, N; Mørland, J; Olsen, H1
Barrett, DA; Pawula, M; Shaw, PN1
Säwe, J; Svensson, JO; Yue, QY1
O'Neal, CL; Poklis, A1
Braithwaite, R; George, S; Meadway, C2
Bechtel, PR; Bechtel, Y; Berard, M; Haffen, E; Masuyer, C; Paintaud, G1
Geisslinger, G; Hofmann, U; Lötsch, J; Rohrbacher, M; Schmidt, H; Schwab, M; Skarke, C1
Augsburger, M; Champod, C; Cherix, D; Giroud, C; Kharbouche, H; Mangin, P; Sporkert, F; Wyss, C1
Auwaerter, V; Dresen, S; Ferreirós, N; Hentschel, R; Hermanns-Clausen, M; Müller, C; Skopp, G; Thierauf, A; Trittler, R; Weinmann, W1
Choi, H; Chung, H; Chung, KH; Han, E; Jwa, SH; Kim, E; Lee, S; Oh, SM; Yun, YM1
Frost, J; Helland, A; Nordrum, IS; Slørdal, L1
Coluzzi, F; Mattia, C1
Belford, M; Manicke, NE1
Frost, J; Helland, A; Løkken, TN; Nordrum, IS; Slørdal, L1

Reviews

2 review(s) available for norcodeine and morphine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:3

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Codeine; Drug Combinations; Drug Therapy, Combination; Humans; Morphine; Pain; Treatment Outcome

2015

Trials

1 trial(s) available for norcodeine and morphine

ArticleYear
Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:1

    Topics: Adult; Algorithms; Analgesics, Opioid; Area Under Curve; Central Nervous System; Codeine; Cytochrome P-450 CYP2D6; Data Interpretation, Statistical; Dealkylation; Female; Humans; Infusions, Intravenous; Male; Models, Statistical; Morphine; Morphine Derivatives; Pupil

2006

Other Studies

24 other study(ies) available for norcodeine and morphine

ArticleYear
Octanol-, chloroform-, and propylene glycol dipelargonat-water partitioning of morphine-6-glucuronide and other related opiates.
    Journal of medicinal chemistry, 1996, Oct-25, Volume: 39, Issue:22

    Topics: Biological Transport; Chemical Phenomena; Chemistry, Physical; Chloroform; Hydrogen-Ion Concentration; Morphine Derivatives; Narcotics; Octanols; Potentiometry; Solutions; Solvents

1996
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
    Nature chemical biology, 2017, Volume: 13, Issue:5

    Topics: Calcium; Cell Degranulation; Cell Line; Computer Simulation; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mast Cells; Molecular Docking Simulation; Molecular Probes; Molecular Structure; Nerve Tissue Proteins; Pyrazoles; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Structure-Activity Relationship

2017
Letter: Question about the formation of norcodeine from morphine in man.
    The Journal of pharmacy and pharmacology, 1975, Volume: 27, Issue:3

    Topics: Codeine; Drug Contamination; Humans; Morphine

1975
Pharmacokinetics and metabolism of codeine in humans.
    Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:6

    Topics: Adult; Codeine; Female; Half-Life; Humans; Male; Middle Aged; Morphine; Morphine Derivatives; Protein Binding

1992
Direct determination of codeine, norcodeine, morphine and normorphine with their corresponding O-glucuronide conjugates by high-performance liquid chromatography with electrochemical detection.
    Journal of chromatography, 1991, Oct-04, Volume: 570, Issue:2

    Topics: Chromatography, High Pressure Liquid; Codeine; Electrochemistry; Glucuronates; Humans; Hydrolysis; Morphine; Morphine Derivatives; Reproducibility of Results

1991
Lack of effect of paracetamol on the pharmacokinetics and metabolism of codeine in man.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:4

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Codeine; Drug Interactions; Female; Humans; Male; Metabolic Clearance Rate; Morphine; Time Factors

1991
Species differences in metabolism of codeine: urinary excretion of codeine glucuronide, morphine-3-glucuronide and morphine-6-glucuronide in mice, rats, guinea pigs and rabbits.
    Xenobiotica; the fate of foreign compounds in biological systems, 1990, Volume: 20, Issue:7

    Topics: Animals; Chromatography, High Pressure Liquid; Codeine; Guinea Pigs; Male; Mice; Morphine; Morphine Derivatives; Rabbits; Rats; Rats, Inbred Strains; Species Specificity

1990
Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:1

    Topics: Antibodies, Monoclonal; Blotting, Western; Codeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Levorphanol; Microsomes, Liver; Morphine; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenotype; Polymorphism, Genetic

1990
Simultaneous determination of codeine, norcodeine and morphine in biological fluids by high-performance liquid chromatography with fluorescence detection.
    Journal of chromatography, 1989, Jul-21, Volume: 491, Issue:2

    Topics: Adult; Chromatography, High Pressure Liquid; Codeine; Humans; Male; Molecular Structure; Morphine; Particle Size; Spectrometry, Fluorescence

1989
Determination of codeine and its metabolites in human blood plasma and in microsomal incubates by high-performance liquid chromatography with ultraviolet detection.
    Journal of chromatography, 1989, Jul-21, Volume: 491, Issue:2

    Topics: Chromatography, High Pressure Liquid; Codeine; Glucuronates; Humans; Microsomes, Liver; Morphine

1989
Ethanol inhibition of codeine and morphine metabolism in isolated rat hepatocytes.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1

    Topics: Animals; Cells, Cultured; Codeine; Ethanol; Liver; Morphine; Morphine Derivatives; Rats

1986
Determination of codeine and its metabolites in microsomal incubates by high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1994, Feb-18, Volume: 653, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Codeine; Electrochemistry; Microsomes, Liver; Morphine; Rats; Spectrophotometry, Ultraviolet

1994
Determination of codeine and metabolites in plasma and urine using ion-pair high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1995, Dec-01, Volume: 674, Issue:1

    Topics: Calibration; Chromatography, High Pressure Liquid; Codeine; Humans; Morphine; Morphine Derivatives; Substance Abuse Detection

1995
The detection of acetylcodeine and 6-acetylmorphine in opiate positive urines.
    Forensic science international, 1998, Jul-06, Volume: 95, Issue:1

    Topics: Biomarkers; Codeine; Gas Chromatography-Mass Spectrometry; Heroin Dependence; Humans; Morphine; Morphine Derivatives; Narcotics; Reproducibility of Results; Substance Abuse Detection

1998
Opiate concentrations following the ingestion of poppy seed products--evidence for 'the poppy seed defence'.
    Forensic science international, 1998, Aug-31, Volume: 96, Issue:1

    Topics: Administration, Oral; Adult; Codeine; Food Analysis; Gas Chromatography-Mass Spectrometry; Humans; Male; Morphine; Morphine Derivatives; Narcotics; Papaver; Plants, Medicinal; Seeds; Thebaine

1998
On the assessment of drug metabolism by assays of codeine and its main metabolites.
    Therapeutic drug monitoring, 2000, Volume: 22, Issue:3

    Topics: Adult; Chromatography, High Pressure Liquid; Codeine; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Glucuronides; Humans; Linear Models; Male; Methylation; Middle Aged; Morphine; Phenotype; Polymorphism, Genetic; Reproducibility of Results; Sensitivity and Specificity

2000
A rapid GC-MS method for the determination of dihydrocodeine, codeine, norcodeine, morphine, normorphine and 6-MAM in urine.
    Forensic science international, 2002, Jun-25, Volume: 127, Issue:1-2

    Topics: Adolescent; Adult; Codeine; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Morphine; Morphine Derivatives; Narcotics

2002
Codeine accumulation and elimination in larvae, pupae, and imago of the blowfly Lucilia sericata and effects on its development.
    International journal of legal medicine, 2008, Volume: 122, Issue:3

    Topics: Animals; Codeine; Diptera; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Larva; Liver; Morphine; Narcotics; Pupa; Swine

2008
Fatal and severe codeine intoxication in 3-year-old twins--interpretation of drug and metabolite concentrations.
    International journal of legal medicine, 2009, Volume: 123, Issue:5

    Topics: Antitussive Agents; Brain Chemistry; Brain Edema; Child, Preschool; Chromatography, Liquid; Codeine; Cytochrome P-450 CYP2D6; Delayed-Action Preparations; Drug Overdose; Fatal Outcome; Forensic Toxicology; Genotype; Glucuronides; Humans; Medication Errors; Morphine; Morphine Derivatives; Polymorphism, Genetic; Respiratory Aspiration; Tandem Mass Spectrometry; Tissue Distribution; Twins, Monozygotic

2009
Simultaneous quantification of opiates and effect of pigmentation on its deposition in hair.
    Archives of pharmacal research, 2010, Volume: 33, Issue:11

    Topics: Animals; Codeine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Hair Color; Male; Morphine; Morphine Derivatives; Narcotics; Rats; Rats, Zucker; Solid Phase Extraction; Substance Abuse Detection

2010
Investigation of morphine and morphine glucuronide levels and cytochrome P450 isoenzyme 2D6 genotype in codeine-related deaths.
    Forensic science international, 2012, Jul-10, Volume: 220, Issue:1-3

    Topics: Adult; Aged; Codeine; Cytochrome P-450 Enzyme System; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Genotype; Humans; Isoenzymes; Male; Middle Aged; Morphine; Morphine Derivatives; Narcotics; Polymerase Chain Reaction

2012
Separation of opiate isomers using electrospray ionization and paper spray coupled to high-field asymmetric waveform ion mobility spectrometry.
    Journal of the American Society for Mass Spectrometry, 2015, Volume: 26, Issue:5

    Topics: Aerosols; Analgesics, Opioid; Chemistry, Clinical; Codeine; Electrochemical Techniques; Feasibility Studies; Forensic Toxicology; Hydromorphone; Morphine; Paper; Solvents; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry

2015
Post-mortem levels and tissue distribution of codeine, codeine-6-glucuronide, norcodeine, morphine and morphine glucuronides in a series of codeine-related deaths.
    Forensic science international, 2016, Volume: 262

    Topics: Adipose Tissue; Adult; Aged; Brain Chemistry; Chromatography, Liquid; Codeine; Cytochrome P-450 CYP2D6; Female; Forensic Toxicology; Genotype; Humans; Male; Mass Spectrometry; Middle Aged; Morphine; Morphine Derivatives; Muscle, Skeletal; Norway; Postmortem Changes; Solid Phase Extraction; Substance-Related Disorders; Tissue Distribution; Vitreous Body; Young Adult

2016