norcisapride has been researched along with cisapride in 8 studies
*Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed) [MeSH]
*Cisapride: A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed) [MeSH]
| Studies (norcisapride) | Trials (norcisapride) | Recent Studies (post-2010) (norcisapride) | Studies (cisapride) | Trials (cisapride) | Recent Studies (post-2010) (cisapride) |
|---|---|---|---|---|---|
| 8 | 3 | 0 | 1,554 | 390 | 110 |
| Protein | Taxonomy | norcisapride (IC50) | cisapride (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.767 | |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | 3.37 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.3 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0098 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 3.5923 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.07 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.1701 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.35 | |
| Dipeptidyl peptidase 4 | Rattus norvegicus (Norway rat) | 2.69 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0098 | |
| Insulin receptor | Rattus norvegicus (Norway rat) | 3.37 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 2.29 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 3.3827 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 3.26 | |
| D | Rattus norvegicus (Norway rat) | 0.0065 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 3.6495 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0065 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 1.7 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0065 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0065 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 2.29 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.0065 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.083 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.0054 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.2597 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 3.6495 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 4.47 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 4.47 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0098 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.384 | |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | 0.03 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 3.37 | |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | 0.03 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.144 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.9 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.0407 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 2.29 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.535 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.2536 | |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | 0.1701 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.994 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bares, R; Dakshinamurty, KV; Gladziwa, U; Ittel, TH; Klotz, U; Seiler, KU; Sieberth, HG | 1 |
| Cisternino, S; Saulnier, JL; Schlatter, J | 1 |
| Addison, RS; Duffy, SL; Mathers, SR | 1 |
| Bailey, DG; Bend, JR; Dresser, GK; Freeman, DJ; Munoz, C; Offman, EM | 1 |
| Gotschall, RR; Kearns, GL; Leeder, JS; Pearce, RE | 1 |
| Abdel-Rahman, SM; Bertino, JS; Kashuba, AD; Kearns, GL; Khan, IS; Leeder, JS; Lowry, JA; Nafziger, AN; Schuetz, EG; van den Anker, JN | 1 |
| Kearns, GL; Knight, GR; Robinson, PK; van den Anker, JN; Ward, RM; Wilson, JT; Wilson-Costello, D | 1 |
| Barberich, TJ; Hewitt, MC; Shao, L; Wang, F | 1 |
3 trial(s) available for norcisapride and cisapride
| Article | Year |
|---|---|
Red wine-cisapride interaction: comparison with grapefruit juice.
Topics: Adult; Area Under Curve; Beverages; Cisapride; Citrus; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Food-Drug Interactions; Gastrointestinal Agents; Humans; Male; Mixed Function Oxygenases; Reference Values; Wine | 2001 |
Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Topics: Administration, Oral; Adolescent; Adult; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Chromatography, High Pressure Liquid; Cisapride; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Humans; Infusions, Intravenous; LLC-PK1 Cells; Male; Mass Spectrometry; Midazolam; Middle Aged; Models, Biological; Regression Analysis; Swine | 2003 |
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny.
Topics: Area Under Curve; Chromatography, High Pressure Liquid; Cisapride; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Gastrointestinal Agents; Half-Life; Humans; Infant; Infant, Newborn; Male; Metabolic Clearance Rate | 2003 |
5 other study(ies) available for norcisapride and cisapride
| Article | Year |
|---|---|
Pharmacokinetics and pharmacodynamics of cisapride in patients undergoing hemodialysis.
Topics: Adult; Aged; Analysis of Variance; Chromatography, Gas; Chromatography, High Pressure Liquid; Cisapride; Female; Gastric Emptying; Humans; Kidney Failure, Chronic; Male; Middle Aged; Monitoring, Physiologic; Piperidines; Renal Dialysis | 1991 |
Determination of cisapride and norcisapride in human plasma using high-performance liquid chromatography with ultraviolet detection.
Topics: Chromatography, High Pressure Liquid; Cisapride; Gastrointestinal Agents; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1998 |
A simple high-performance liquid chromatography assay for the major cisapride metabolite, norcisapride, in human urine.
Topics: Chromatography, High Pressure Liquid; Cisapride; Humans; Indicators and Reagents; Reproducibility of Results | 1999 |
Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Topics: Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cisapride; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Isoenzymes; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Stereoisomerism | 2001 |
mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I).
Topics: Analgesics, Opioid; Cisapride; Gastrointestinal Transit; Humans; Metoclopramide; Receptors, Opioid, mu; Receptors, Serotonin, 5-HT4; Respiratory System; Serotonin 5-HT4 Receptor Agonists; Stereoisomerism; Tramadol | 2009 |