norbinaltorphimine and thiophane

norbinaltorphimine has been researched along with thiophane* in 1 studies

Other Studies

1 other study(ies) available for norbinaltorphimine and thiophane

Article	Year
Dynorphin inhibits NEP activity in R1.1 mouse thymoma cells. Cell biochemistry and function, 2008, Volume: 26, Issue:8 NEP/CALLA or CD10 is an endopeptidase (E.C. 3.4.24.11) that inactivates numerous neuropeptides, including dynorphin. Dynorphin is an endogenous opioid polypeptide that binds to kappa-opioid receptors with greatest affinity. R1.1 mouse thymoma cells highly express kappa-opioid receptors. In this study, on R1.1 cells, NEP activity was inhibited by kappa-opioid polypeptide dynorphin (10(-8)-10(-6) M) and by thiorphan (2 x 10(-4) M), a known inhibitor of NEP (30 min treatment). NEP inhibition by dynorphin was stronger than by thiorphan. A non-opioid opioid mechanism of action was mostly involved in this inhibition. Topics: Animals; Cell Line, Tumor; Dynorphins; Mice; Naltrexone; Narcotic Antagonists; Neprilysin; Receptors, Opioid, kappa; Thiophenes; Thymoma; Thymus Neoplasms	2008

Article

Year

Dynorphin inhibits NEP activity in R1.1 mouse thymoma cells.

Cell biochemistry and function, 2008, Volume: 26, Issue:8

NEP/CALLA or CD10 is an endopeptidase (E.C. 3.4.24.11) that inactivates numerous neuropeptides, including dynorphin. Dynorphin is an endogenous opioid polypeptide that binds to kappa-opioid receptors with greatest affinity. R1.1 mouse thymoma cells highly express kappa-opioid receptors. In this study, on R1.1 cells, NEP activity was inhibited by kappa-opioid polypeptide dynorphin (10(-8)-10(-6) M) and by thiorphan (2 x 10(-4) M), a known inhibitor of NEP (30 min treatment). NEP inhibition by dynorphin was stronger than by thiorphan. A non-opioid opioid mechanism of action was mostly involved in this inhibition.

Topics: Animals; Cell Line, Tumor; Dynorphins; Mice; Naltrexone; Narcotic Antagonists; Neprilysin; Receptors, Opioid, kappa; Thiophenes; Thymoma; Thymus Neoplasms

2008