noratropine and 1-aminocyclopropane-1-carboxylic-acid

noratropine has been researched along with 1-aminocyclopropane-1-carboxylic-acid* in 1 studies

Other Studies

1 other study(ies) available for noratropine and 1-aminocyclopropane-1-carboxylic-acid

ArticleYear
Norlittorine and norhyoscyamine identified as products of littorine and hyoscyamine metabolism by (13)C-labeling in Datura innoxia hairy roots.
    Phytochemistry, 2012, Volume: 74

    The presence of two compounds, norlittorine and norhyoscyamine, has been reported in leaves and roots of Datura innoxia; however their metabolic origin in the tropane alkaloid pathway has remained unknown. Precise knowledge of this pathway is a necessary pre-requisite to optimize the production of hyoscyamine and scopolamine in D. innoxia hairy root cultures. The exact structure of norlittorine and norhyoscyamine was confirmed by LC-MS/MS and NMR analyses. Isotopic labeling experiments, using [1-(13)C]-phenylalanine, [1'-(13)C]-littorine and [1'-(13)C]-hyoscyamine, combined with elicitor treatments, using methyl jasmonate, coronalon and 1-aminocyclopropane-1-carboxylic acid, were used to investigate the metabolic origin of the N-demethylated tropane alkaloids. The results suggest that norlittorine and norhyoscyamine are induced under stress conditions by conversion of littorine and hyoscyamine. We propose the N-demethylation of tropane alkaloids as a mechanism to detoxify cells in overproducing conditions.

    Topics: Acetates; Adaptation, Physiological; Amino Acids, Cyclic; Atropine; Atropine Derivatives; Carbon Isotopes; Cell Culture Techniques; Cyclopentanes; Datura; Isoleucine; Methylation; Molecular Structure; Oxylipins; Plant Roots; Scopolamine; Staining and Labeling; Stress, Physiological

2012