noramidopyrine has been researched along with dipyrone in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (53.85) | 18.7374 |
| 1990's | 16 (20.51) | 18.2507 |
| 2000's | 7 (8.97) | 29.6817 |
| 2010's | 10 (12.82) | 24.3611 |
| 2020's | 3 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Bisogno, T; Cascio, MG; Di Marzo, V; Imming, P; Lichtman, AH; Nüsing, R; Podlewski, A; Rogosch, T; Schlosburg, J; Sinning, C; Watzer, B | 1 |
| Granit, L; Levy, M; Zylber-Katz, E | 2 |
| Hoffmann, A; Huster, A; Kraul, H; Töpfer, R; Truckenbrodt, J | 1 |
| Bacracheva, N; Badian, M; Verho, M; Vlahov, V | 1 |
| Marciniec, B; Wojciechowska, B | 1 |
| Granit, L; Levy, M; Stessman, J; Zylber-Katz, E | 1 |
| Carrington, P; Craig, A; Houghton, JB; Routledge, RC; Will, A | 1 |
| Hoshi, K; Igarashi, T; Kitagawa, H; Satoh, T; Senda, N; Ueno, K | 4 |
| Achard, F; Denavit, M; Roche, M | 1 |
| Funae, Y; Imaoka, S; Inoue, K | 1 |
| Burckart, GJ; D'Souza, MJ; Venkataramanan, R; Zemaitis, MA | 1 |
| Chinea, B; Libra, C; Mollica, Q; Savoca, G | 1 |
| Albengres, E; Cuny, M; Moritz, S; Piacentino, A; Revuz, J; Roujeau, JC; Touraine, R | 1 |
| Bona, L; Monza, G; Pollavini, S | 1 |
| Brune, K; Peskar, BA | 1 |
| Le Grignou, P; Michelet, FX; Pinsolle, J | 1 |
| Goto, S; Iguchi, S; Matsuyama, K; Noda, A; Tanaka, T | 2 |
| Chancelade, C | 1 |
| Auzépy, P; Bottineau, G; Richard, C; Rimailho, A; Riou, B; Trincard, MD | 1 |
| Ivanov, D; Staneva-Stoycheva, D | 1 |
| Bavoso, P; Carnimeo, N; Foschino-Barbaro, MP; Picca, V; Resta, O | 1 |
| Drexler, R; Levy, M; Matzner, Y | 1 |
| Flusser, D; Granit, L; Levy, M; Zylber-Katz, E | 1 |
| Chistolini, A; Conti, L; Fidani, P; Francesconi, M; Gandolfo, GM; Mazzucconi, MG | 1 |
| Offerhaus, L | 1 |
| Altrogge, G; Pola, W; Sistovaris, N; Wolhoff, H | 1 |
| Asmardi, G; Jamali, F | 1 |
| Dimitrov, D; Mihailova, D; Russeva, V | 1 |
| Gramatzki, S; Heinemeyer, G; Hildebrandt, AG; Nigam, S; Roots, I | 1 |
| Breyer-Pfaff, U; Egberts, EH; Harder, M | 1 |
| Aarons, LJ; Houston, JB; Rhodes, JC | 1 |
| Fujimori, K; Inoue, K; Mizokami, K; Omori, Y; Sunouchi, M; Takanaka, A | 1 |
| Pola, W; Sistovaris, N; Wolhoff, H | 1 |
| Jontschev, C; Welikowa, E | 1 |
| Haustein, KO; Hüller, G | 1 |
| Cibin, M; Fernandes, D; Gibin, P; Lio, S; Marcello, R; Neri, A; Ruffin, M; Scarpa, A | 1 |
| Carretero, I; Laserna, JJ; Vadillo, JM | 1 |
| Dennhardt, R; Gramm, HJ; Heinemeyer, G; Roots, I; Simgen, W | 1 |
| Caraco, Y; Granit, L; Levy, M; Zylber-Katz, E | 1 |
| Bacracheva, N; Kamali, F | 1 |
| Böcker, R; Geisslinger, G; Levy, M | 1 |
| Hoffmann, A; Lautenschlager, MT; Müller, UA; Viktor, S | 1 |
| Coudert, P; Couquelet, J; Rohet, F; Rubat, C | 1 |
| Böttcher, M; Hapke, HJ; Klaus, AM; Kleinitz, U; Schlingloff, Y | 1 |
| Caraco, Y; Cohen, O; Granit, L; Levy, M; Zylber-Katz, E | 1 |
| Jászberényi, M; Pataki, I; Telegdy, G | 1 |
| Alemany, S; Campos, C; de Gregorio, R; Gago, F; García-Nieto, R; Ortiz, P | 1 |
| Cui, JB; Jiang, XG; Xi, NZ | 1 |
| Estrela, RC; Ribeiro, FM; Struchiner, CJ; Suarez-Kurtz, G; Vicente, FL | 1 |
| Caraco, Y; Granit, L; Levy, M; Safadi, R; Zylber-Katz, E | 1 |
| Di Paola, R; Ferrannini, A; Napoli, G; Nettis, E; Tursi, A | 1 |
| Artaza, MA; Laporte, JR; Ortiz, R; Puerta, JL | 1 |
| Bianchi, L; Büchtemann, A; Herdeg, C; Hilt, F; Klein, R | 1 |
| ELIAS COSTA, JD | 1 |
| BOSSHARD, H; GORDONOFF, T | 1 |
| FECKO, J; KALINOWSKI, K | 1 |
| ALEXANDER, K; KHREIS, A; TRAUT, G | 1 |
| KAWAMURA, K; ONISHI, R; ONO, S | 1 |
| CHITI, W | 1 |
| Ebel, R; Hohlfeld, T; Höltje, HD; Jessen, G; Schrör, K; Weber, AA; Weber, H; Zimmermann, N | 1 |
| Ojha, A; Padh, H; Rathod, R | 1 |
| Cheng, M; Fan, F; Tu, H; Wang, C; Xie, X; Yuan, Z; Zhang, C; Zhang, H; Zhang, Z | 1 |
| Calzadilla, PC; Cortés-Arroyo, AR; Domínguez-Ramírez, AM; Gómez-Hernández, M; Hurtado Y de la Peña, M; López, JR; López-Muñoz, FJ | 1 |
| Aguiar, FA; Assis, DC; Clososki, GC; de Melo, MC; de Souza, GE; Ferreira, SH; Jabor, VA; Kalapothakis, E; Malvar, Ddo C; Vaz, Ade L | 1 |
| Burmańczuk, A; Giorgi, M; Grabowski, T; Kowalski, C; Owen, H | 1 |
| Chea, B; Giorgi, M; Kim, TW; Lebkowska-Wieruszewska, B; Owen, H; Poapolathep, A | 1 |
| Bundscherer, A; Graf, B; Malsy, M | 1 |
| Bachmann, F; Duthaler, U; Haschke, M; Krähenbühl, S; Rudin, D | 1 |
| Abilova, Z; Giorgi, M; Kim, TW; Lisowski, A; Owen, H; Poapolathep, A; Sitovs, A; Łebkowska-Wieruszewska, B | 1 |
| Duthaler, U; Krähenbühl, S; Roos, NJ; Rudin, D | 1 |
| Bachmann, F; Duthaler, U; Krähenbühl, S; Meyer Zu Schwabedissen, HE | 1 |
| Araújo-Silva, G; Arcoverde, KN; de Macêdo, LB; de Paiva, ALC; de Paula, VV; Fernandes, NS; Mouta, AN; Nunes, TL; Urizar, JTP | 1 |
| Chen, X; Huang, X; Li, Q; Li, Z; Mao, Y; Song, L; Tian, H; Wang, J; Wang, Y; Wang, Z; Zhang, X | 1 |
11 trial(s) available for noramidopyrine and dipyrone
| Article | Year |
|---|---|
Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium.
Topics: Administration, Oral; Adult; Aminopyrine; Ampyrone; Antipyrine; Dipyrone; Humans; Male; Pyrazolones; Random Allocation; Time Factors | 1990 |
Controlled trial of two nonsteroidal anti-inflammatory drugs in postoperative pain relief: a 12-hour evaluation.
Topics: Adult; Aminopyrine; Anti-Inflammatory Agents; Clinical Trials as Topic; Dipyrone; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain, Postoperative; Phenylpropionates; Pyrazolones; Random Allocation; Time Factors | 1985 |
Asthma relieved by acetylsalicylic acid and nonsteroid anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Asthma; Dipyrone; Female; Forced Expiratory Volume; Humans; Indomethacin; Male; Middle Aged; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazolones; Respiratory Function Tests | 1984 |
[Comparison of serum concentrations of caffeine, 4-methylaminoantipyrine, sulfamethazine and debrisoquin following oral administration of these substances as a cocktail in type II diabetics before and after insulin therapy].
Topics: Adult; Aged; Anti-Infective Agents; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Debrisoquin; Diabetes Mellitus, Type 2; Dipyrone; Drug Combinations; Female; Humans; Hypoglycemic Agents; Insulin; Isoenzymes; Male; Middle Aged; Pyrazolones; Sulfamethazine; Sympatholytics | 1996 |
Cerebrospinal fluid and plasma concentrations of dipyrone metabolites after a single oral dose of dipyrone.
Topics: Administration, Oral; Adult; Aged; Aminopyrine; Ampyrone; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Dipyrone; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyrazolones; Spinal Puncture | 1998 |
Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone.
Topics: Adult; Area Under Curve; Confidence Intervals; Cross-Over Studies; Dipyrone; Humans; Male; Pyrazolones; Therapeutic Equivalency | 2001 |
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.
Topics: Acetylation; Adult; Algorithms; Aminopyrine; Ampyrone; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Carrier State; Dipyrone; Female; Half-Life; Hepatitis B virus; Humans; Male; Metabolic Clearance Rate; Models, Biological; Pyrazolones | 2001 |
Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria.
Topics: Acetaminophen; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzydamine; Dipyrone; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Italy; Male; Middle Aged; Pyrazolones; Single-Blind Method; Sulfonamides; Urticaria | 2002 |
Bioavailability of two metamizole (dipyrone) solutions as single doses of 2 g versus metamizole capsules.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Capsules; Cross-Over Studies; Dipyrone; Female; Humans; Male; Middle Aged; Pyrazolones; Solutions | 2002 |
Pharmacokinetic profiles of the two major active metabolites of metamizole (dipyrone) in cats following three different routes of administration.
Topics: Administration, Oral; Ampyrone; Analgesics; Animals; Cats; Cross-Over Studies; Dipyrone; Injections, Intramuscular; Injections, Intravenous; Male | 2018 |
Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine.
Topics: Ciprofloxacin; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dipyrone; Fluconazole; Humans; Male | 2022 |
67 other study(ies) available for noramidopyrine and dipyrone
| Article | Year |
|---|---|
Novel bioactive metabolites of dipyrone (metamizol).
Topics: Administration, Oral; Aminopyridines; Ampyrone; Animals; Central Nervous System; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dipyrone; Enzyme Activation; Mice; Mice, Inbred C57BL; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reference Standards; Spectrometry, Mass, Electrospray Ionization | 2012 |
Formation and excretion of dipyrone metabolites in man.
Topics: Administration, Oral; Adult; Aminopyrine; Ampyrone; Chromatography, High Pressure Liquid; Dipyrone; Half-Life; Humans; Male; Pyrazolones | 1992 |
Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adult; Biotransformation; Dipyrone; Female; Humans; Liver Diseases; Male; Middle Aged; Pyrazolones | 1991 |
[Analysis of 5-pyrazolinone derivatives in pharmaceutical products. I. Spectrophotometric analysis of two-component drugs containing propyphenazone].
Topics: Aminopyrine; Anti-Inflammatory Agents; Antipyrine; Barbiturates; Chromatography, Thin Layer; Dipyrone; Drug Combinations; False Negative Reactions; Poland; Pyrazolones; Spectrophotometry, Ultraviolet | 1989 |
Effect of age on the pharmacokinetics of dipyrone.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aminopyrine; Creatinine; Dipyrone; Female; Half-Life; Humans; Male; Pyrazolones | 1989 |
Noramidopyrine-induced agranulocytosis.
Topics: Adult; Agranulocytosis; Aminopyrine; Dipyrone; Humans; Male; Pyrazolones | 1989 |
Effect of repeated administration of monomethyl-aminoantipyrine on the activities of gamma-glutamyltranspeptidase and microsomal drug metabolizing enzymes in rat liver.
Topics: Aminopyrine; Animals; Body Weight; Cytochrome P-450 Enzyme System; Dipyrone; gamma-Glutamyltransferase; In Vitro Techniques; Kidney; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Proteins; Pyrazolones; Rats; Rats, Inbred Strains | 1985 |
Enhancement of monomethylaminoantipyrine-induced increase of hepatic gamma-glutamyltranspeptidase activity by cobaltous chloride in rats.
Topics: Aminopyrine; Animals; Cobalt; Cytochrome P-450 Enzyme System; Cytosol; Dipyrone; Drug Synergism; gamma-Glutamyltransferase; In Vitro Techniques; Liver; Male; Microsomes, Liver; Pyrazolones; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Effects of co-administration of monomethylaminoantipyrine with diethylaminoethyl 2,2-diphenylvalerate (SKF 525-A) on gamma-glutamyltranspeptidase, glutathione S-transferase and hepatic drug metabolizing enzyme activities in rats.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Cytosol; Dipyrone; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Liver; Male; Mixed Function Oxygenases; Proadifen; Pyrazolones; Rats; Rats, Inbred Strains | 1986 |
[Differentiation of the effects of antispasmodic agents on the electromyogram of the sphincter of Oddi and the duodenum of the alert rabbit].
Topics: Ampulla of Vater; Animals; Atropine Derivatives; Benzophenones; Dipyrone; Drug Combinations; Drug Interactions; Duodenum; Electromyography; Female; Gastrointestinal Motility; Male; Muscle, Smooth; Parasympatholytics; Piperidines; Pyrazolones; Rabbits; Sphincter of Oddi | 1985 |
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.
Topics: Aminopyrine; Ampyrone; Animals; Antipyrine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dipyrone; Female; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazolones; Rats; Rats, Inbred Strains | 1988 |
Simple high-performance liquid chromatographic method for simultaneous determination of aminopyrine and its metabolites.
Topics: Aminopyrine; Ampyrone; Animals; Chromatography, High Pressure Liquid; Dipyrone; Half-Life; Injections, Intravenous; Male; Microsomes, Liver; Pyrazolones; Rabbits | 1987 |
Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats.
Topics: Aminopyrine; Animals; Cobalt; Dipyrone; Drinking; Drug Interactions; Eating; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Liver; Male; Organ Size; Pyrazolones; Rats; Rats, Inbred Strains; Transferases | 1987 |
[Comparison between imidazole-2-hydroxybenzoate and noramidopyrine in the treatment of postoperative pain in orthopedic patients].
Topics: Adolescent; Adult; Aged; Aminopyrine; Anti-Inflammatory Agents; Bone and Bones; Child; Dipyrone; Female; Humans; Imidazoles; Male; Middle Aged; Pain, Postoperative; Pyrazolones; Salicylates | 1985 |
Lymphocyte transformation test in drug-induced toxic epidermal necrolysis.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Dipyrone; Drug Combinations; Female; Flurbiprofen; Humans; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Oxyphenbutazone; Phenylbutyrates; Piroxicam; Propionates; Pyrazolones; Stevens-Johnson Syndrome; Sulfadiazine; Sulfamethoxazole; Thiazines; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
Modulation by drugs of leukotriene and prostaglandin production from mouse peritoneal macrophages.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetaminophen; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Dinoprostone; Dipyrone; Indomethacin; Macrophages; Male; Mice; Propionates; Prostaglandins E; Pyrazoles; Pyrazolones; SRS-A | 1985 |
[Comparative study of the analgesic activity of 1 g injectable Aspegic and injectable Noramidopyrine].
Topics: Adult; Aged; Aminopyrine; Analgesics; Aspirin; Dipyrone; Female; Humans; Lysine; Male; Middle Aged; Neoplasms; Pain, Postoperative; Pyrazolones; Surgery, Plastic | 1985 |
Product inhibition of aminopyrine N-demethylation in isolated hepatocytes.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Dealkylation; Dipyrone; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Indicators and Reagents; Kinetics; Liver; Male; Pyrazolones; Rats; Rats, Inbred Strains | 1985 |
Plasma protein binding of dipyrone metabolites in man.
Topics: Acetaminophen; Adult; Aminopyrine; Ampyrone; Aspirin; Blood Proteins; Dipyrone; Female; Humans; Ibuprofen; Male; Protein Binding; Pyrazolones | 1985 |
[Detoxication of a drug-dependent patient (author's transl)].
Topics: Adult; Analgesics, Opioid; Dipyrone; Humans; Male; Pyrazolones; Substance-Related Disorders; Tiapamil Hydrochloride | 1982 |
[Acute immunoallergic interstitial nephritis due to noramidopyrine].
Topics: Acute Disease; Aminopyrine; Biopsy; Dipyrone; Drug Hypersensitivity; Humans; Hypersensitivity, Delayed; Kidney; Male; Middle Aged; Nephritis, Interstitial; Pyrazolones | 1984 |
On some presynaptic effects of meramyzole (analgine-pharmachim).
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Dipyrone; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrazolones; Sodium; Synapses; Vas Deferens | 1984 |
Effect of dipyrone, acetylsalicylic acid and acetaminophen on human neutrophil chemotaxis.
Topics: Acetaminophen; Aminopyrine; Ampyrone; Aspirin; Chemotaxis, Leukocyte; Dipyrone; Dose-Response Relationship, Drug; Humans; Neutrophils; Pyrazolones | 1984 |
Plasma kinetics of dipyrone metabolites in rapid and slow acetylators.
Topics: Acetylation; Adult; Aminopyrine; Ampyrone; Chemical Phenomena; Chemistry; Dipyrone; Female; Half-Life; Humans; Kinetics; Male; Pyrazolones | 1984 |
Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay.
Topics: Adolescent; Adult; Aminopyrine; Anti-Bacterial Agents; Aspirin; Autoantibodies; Blood Platelets; Child; Child, Preschool; Coombs Test; Dipyrone; Drug Hypersensitivity; Female; Humans; Immunoglobulin G; Infant; Male; Middle Aged; Purpura, Thrombocytopenic; Pyrazolones | 1984 |
[Russian roulette with pyrazolones].
Topics: Agranulocytosis; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Female; Humans; Male; Oxyphenbutazone; Phenylbutazone; Pyrazoles; Pyrazolones; Rheumatic Diseases | 1983 |
[Metamizol--acute overdose with suicidal intent].
Topics: Adolescent; Aminopyrine; Ampyrone; Biotransformation; Dipyrone; Female; Furosemide; Humans; Pyrazolones; Suicide, Attempted | 1983 |
High-performance liquid chromatography of dipyrone and its active metabolite in biological fluids.
Topics: Adult; Aminopyrine; Biotransformation; Chromatography, High Pressure Liquid; Dipyrone; Half-Life; Humans; Male; Pyrazolones | 1983 |
Influence of phenobarbital and 3-methylcholanthrene on the metabolism of aminopyrine in isolated hepatocyte system.
Topics: Aminopyrine; Animals; Chromatography, High Pressure Liquid; Dipyrone; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenobarbital; Pyrazolones; Rats; Rats, Inbred Strains | 1983 |
Studies on protein binding of analgin.
Topics: Aminopyrine; Blood Proteins; Dialysis; Dipyrone; Humans; Protein Binding; Pyrazolones; Serum Albumin | 1983 |
Hybrid information provided by the 14C-aminopyrine breath test. Studies with 14C-monomethylaminoantipyrine in the guinea pig.
Topics: Aminopyrine; Animals; Breath Tests; Carbon Dioxide; Dipyrone; Guinea Pigs; Half-Life; Male; Phenobarbital; Pyrazolones | 1980 |
Plasma levels of parent drug and metabolites in the intravenous aminopyrine breath test.
Topics: Adult; Aged; Aminopyrine; Biotransformation; Breath Tests; Carbon Dioxide; Dipyrone; Female; Humans; Kinetics; Male; Middle Aged; Pyrazolones | 1982 |
Interpretation of CO2 exhalation rate data from demethylation of aminopyrine and its metabolite monomethylaminoantipyrine.
Topics: Aminopyridines; Aminopyrine; Carbon Dioxide; Dealkylation; Dipyrone; Humans; Kinetics; Pyrazolones; Respiration | 1982 |
Simultaneous determination of aminopyrine hydroxylation and aminopyrine N-demethylation in liver microsomes by high-performance liquid chromatography.
Topics: Aminopyrine; Ampyrone; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dipyrone; Hydroxylation; Methylation; Microsomes, Liver; Pyrazolones; Rats | 1983 |
Thin-layer chromatographic determination of major metamizole metabolites in serum and urine.
Topics: Adolescent; Aminopyrine; Ampyrone; Chromatography, Thin Layer; Dipyrone; Female; Half-Life; Humans; Kinetics; Pyrazolones | 1983 |
[Optimization of the composition of a multicomponent drug form by mathematical investigational designing and experimental testing (author's transl)].
Topics: Aminopyrine; Benzoates; Caffeine; Dipyrone; Drug Combinations; Drug Compounding; Models, Theoretical; Pharmaceutic Aids; Pyrazolones | 1981 |
[Quantitative thin-layer chromatographic estimation of aminophenazone (I.N.N.), 4-methylaminophenazone and 4-aminophenazone in plasma (author's transl)].
Topics: Aminopyrine; Ampyrone; Antipyrine; Chromatography, Thin Layer; Dipyrone; Humans; Pyrazolones; Time Factors | 1981 |
[The efficacy and rapidity of action of granulocyte colony-stimulating factor in a case of agranulocytosis due to noramidopyrine].
Topics: Agranulocytosis; Dipyrone; Drug Evaluation; Drug Therapy, Combination; Female; Granulocyte Colony-Stimulating Factor; Humans; Middle Aged; Pyrazolones | 1994 |
Determination of antipyrine metabolites in human plasma by solid-phase extraction and micellar liquid chromatography.
Topics: Aminopyrine; Ampyrone; Antipyrine; Chromatography, Liquid; Dipyrone; Humans; Micelles; Pyrazolones; Reproducibility of Results | 1995 |
The kinetics of metamizol and its metabolites in critical-care patients with acute renal dysfunction.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Ampyrone; Critical Care; Dipyrone; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Pyrazolones; Shock, Septic | 1993 |
Validity of saliva samples for the estimation of dipyrone metabolites pharmacokinetics.
Topics: Acetylation; Adult; Aminopyrine; Ampyrone; Dipyrone; Female; Half-Life; Humans; Male; Phenotype; Pyrazolones; Saliva | 1993 |
Lack of interaction between zidovudine and 4-methyl-amino-antipyrine, the active metabolite of metamizole, in human liver in vitro.
Topics: Antiviral Agents; Dipyrone; Drug Interactions; Glucuronates; Humans; In Vitro Techniques; Male; Microsomes, Liver; Pyrazolones; White People; Zidovudine | 1995 |
High-performance liquid chromatographic analysis of dipyrone metabolites to study their formation in human liver microsomes.
Topics: Aminopyrine; Ampyrone; Chromatography, High Pressure Liquid; Dipyrone; Humans; Microsomes, Liver; Pyrazolones; Spectrophotometry, Ultraviolet | 1996 |
Synthesis and analgesic effects of 3-substituted 4,6-diarylpyridazine derivatives of the arylpiperazine class.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoquinones; Dipyrone; Dose-Response Relationship, Drug; Drug Design; Drug Interactions; Injections, Intraperitoneal; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Neurotoxins; Pain; Pyrazolones; Pyridazines; Receptors, Opioid; Reference Standards; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Trazodone | 1997 |
Pharmacokinetic study of dipyrone metabolite 4-MAA in the horse and possible implications for doping control.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Dipyrone; Doping in Sports; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Horses; Male; Metabolic Clearance Rate; Pyrazolones | 1997 |
Hyperthermic effect of centrally administered natriuretic peptides in the rat.
Topics: Animals; Atrial Natriuretic Factor; Body Temperature; Colon; Cyclooxygenase Inhibitors; Dipyrone; Dose-Response Relationship, Drug; Fever; Injections, Intraventricular; Male; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Pyrazolones; Rats; Rats, Wistar | 1999 |
Regulation of cyclooxygenase activity by metamizol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cattle; Cell Extracts; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dipyrone; Dose-Response Relationship, Drug; Humans; Isoenzymes; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrazolones; Sheep | 1999 |
[Studies on HPLC method for determination of 4-methylaminoantipyrine and relative bioavailabilities of analgin nasal drops in human volunteers].
Topics: Administration, Intranasal; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chromatography, High Pressure Liquid; Dipyrone; Humans; Male; Middle Aged; Pyrazolones | 1997 |
Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.
Topics: Aged; Aminopyrine; Ampyrone; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dipyrone; Dose-Response Relationship, Drug; Drug Hypersensitivity; Humans; Lymphocyte Activation; Male; Pyrazolones | 2002 |
[Experience with 4-methylaminoantipyrine sodium methanesulfonate in suppositories as postoperative analgesic in gynecology].
Topics: Analgesics; Dipyrone; Female; Genitalia; Genitalia, Female; Gynecology; Humans; Mesylates; Pain Management; Postoperative Period; Sodium; Suppositories | 1955 |
[On the pharmacology of a combination of noramidopyrine methane sulfonate and choline. 1].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Choline; Dipyrone; Methane | 1963 |
[Iodocoulometric method for the microdetermination of noramidopyrine sodium methanesulfonate (Novalgin)].
Topics: Aminophylline; Dipyrone; Humans; Mesylates; Sodium | 1963 |
[The combined effect of noramidopyrine-methanesulfonate with choline and acetylcholine].
Topics: Acetylcholine; Choline; Dipyrone; Female; Humans; Ileum; Intestines; Mesylates; Pyrazoles; Uterus | 1963 |
[STUDIES ON ANALYSIS OF MIXED ANTI-COLD PHARMACEUTICAL PREPARATIONS. I. COLORIMETRIC DETERMINATION OF SULPYRINE (SODIUM METHYLAMINOANTIPYRINE METHANESULFONATE) WITH 1,2-NAPHTHOQUINONE-4-SULFONIC ACID].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Colorimetry; Dipyrone; Mesylates; Naphthoquinones; Research; Sodium; Sulfonic Acids | 1965 |
[On some derivatives of methylaminoantipyrine].
Topics: Antipyrine; Dipyrone | 1960 |
Pyrazolinone analgesics prevent the antiplatelet effect of aspirin and preserve human platelet thromboxane synthesis.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Blood Platelets; Cells, Cultured; Cyclooxygenase 1; Dipyrone; Drug Antagonism; Humans; Platelet Aggregation; Pyrazolones; Thromboxanes | 2008 |
Quantification of 4-methylaminoantipyrine, the active metabolite of dipyrone, in human plasma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Calibration; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dipyrone; Drug Stability; Humans; Mass Spectrometry; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry | 2009 |
[Experimental study on animal with automatic drug injection based on predictive control for vascular interventional therapy].
Topics: Algorithms; Animals; Automation; Dipyrone; Forecasting; Infusion Pumps; Infusions, Intra-Arterial; Pharmaceutical Preparations; Swine | 2012 |
High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies.
Topics: Aminopyrine; Ampyrone; Animals; Calibration; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dipyrone; Drug Interactions; Male; Morphine; Rats; Rats, Wistar; Solid Phase Extraction | 2012 |
Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever.
Topics: Ampyrone; Animals; Antipyretics; Body Temperature; Dinoprostone; Dipyrone; Fever; Hypothalamus; Hypothermia; Indomethacin; Lipopolysaccharides; Male; Prodrugs; Rats, Wistar; Scorpion Venoms | 2014 |
Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets.
Topics: Ampyrone; Animals; Area Under Curve; Dipyrone; Half-Life; Male; Molecular Structure; Swine | 2016 |
Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dipyrone; Drug Synergism; Humans; Necrosis; Pancreatic Neoplasms | 2017 |
N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole.
Topics: Activation, Metabolic; Analgesics; Antipyrine; Cytochrome P-450 Enzyme System; Demethylation; Dipyrone; Granulocytes; Hepatocytes; HL-60 Cells; Humans; Kinetics; Microsomes, Liver; Peroxidase; Substrate Specificity | 2018 |
Pharmacokinetic profiles of metamizole (dipyrone) active metabolites in goats and its residues in milk.
Topics: Ampyrone; Analgesics; Animals; Antipyrine; Dipyrone; Drug Residues; Female; Goats; Injections, Intramuscular; Injections, Intravenous; Milk | 2018 |
Toxicity of metamizole on differentiating HL60 cells and human neutrophil granulocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antipyrine; Apoptosis; Cell Differentiation; Cell Proliferation; Cell Survival; Dipyrone; Fetal Blood; Granulocytes; Heme Oxygenase-1; Hemin; HL-60 Cells; Humans; Neutrophils; Tumor Stem Cell Assay | 2019 |
Pharmacokinetic profiles of the two major active metabolites of metamizole, 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), after intravenous injection in cats.
Topics: Ampyrone; Animals; Cats; Chromatography, Liquid; Dipyrone; Injections, Intravenous; Tandem Mass Spectrometry | 2023 |
Development of a Lateral Flow Immunoassay Based on a Highly Specific Monoclonal Antibody To Detect 4-Methylaminoantipyrine.
Topics: Antibodies, Monoclonal; Dipyrone; Gold Colloid; Haptens; Immunoassay; Limit of Detection | 2023 |