noralfentanil has been researched along with fentanyl in 7 studies
| Studies (noralfentanil) | Trials (noralfentanil) | Recent Studies (post-2010) (noralfentanil) | Studies (fentanyl) | Trials (fentanyl) | Recent Studies (post-2010) (fentanyl) |
|---|---|---|---|---|---|
| 8 | 0 | 1 | 15,288 | 4,310 | 4,483 |
| Protein | Taxonomy | noralfentanil (IC50) | fentanyl (IC50) |
|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 6.5 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.6342 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0122 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.1888 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0122 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0058 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.3092 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 5.893 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 1.58 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0031 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 1.8197 | |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 4.973 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.354 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guengerich, FP; Wood, AJ; Wood, M; Yun, CH | 1 |
| Cork, RC; Gandolfi, AJ; Perry, DF; Weldon, ST | 1 |
| Hendrickx, JJ; Heykants, JJ; Lauwers, W; Lavrijsen, KL; Meuldermans, WE; Van Dyck, DM; Van Houdt, JM; Woestenborghs, RJ | 1 |
| Kharasch, ED; Kunze, KL; Labroo, RB; Podoll, T; Thummel, KE; Trager, WF | 1 |
| Kharasch, ED; Labroo, R; Mautz, DS | 1 |
| Guengerich, FP; Krivoruk, Y; Tateishi, T; Ueng, YF; Wood, AJ; Wood, M | 1 |
| Andurkar, SV; Clark, CR; DeRuiter, J; Huber, T; Valaer, AK | 1 |
1 review(s) available for noralfentanil and fentanyl
| Article | Year |
|---|---|
Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance.
Topics: Alfentanil; Benzoflavones; Cytochrome P-450 Enzyme System; Drug Interactions; Fentanyl; Humans; Microsomes, Liver | 1992 |
6 other study(ies) available for noralfentanil and fentanyl
| Article | Year |
|---|---|
Detection of picogram levels of sufentanil by capillary gas chromatography.
Topics: Adult; Biotransformation; Chromatography, Gas; Fentanyl; Humans; Male; Microchemistry; Sufentanil | 1985 |
Is the metabolism of alfentanil subject to debrisoquine polymorphism? A study using human liver microsomes.
Topics: Alfentanil; Chromatography, High Pressure Liquid; Debrisoquin; Fentanyl; Humans; Hydroxylation; Isoquinolines; Liver; Metabolism, Inborn Errors; Microsomes; Osmolar Concentration | 1988 |
Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism.
Topics: Alfentanil; Blotting, Western; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; DNA Probes; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Isoenzymes; Microsomes, Liver; Mixed Function Oxygenases | 1995 |
Determination of alfentanil and noralfentanil in human plasma by gas chromatography-mass spectrometry.
Topics: Alfentanil; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Quality Control | 1994 |
Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.
Topics: Analgesics, Opioid; Animals; Antibodies; Antibody Specificity; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Erythromycin; Fentanyl; Humans; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Norpregnenes; Rabbits; Sufentanil; Troleandomycin | 1996 |
Development of a gas chromatographic-mass spectrometric drug screening method for the N-dealkylated metabolites of fentanyl, sufentanil, and alfentanil.
Topics: Alfentanil; Analgesics, Opioid; Drug Residues; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Sensitivity and Specificity; Sufentanil | 1997 |