noralfentanil has been researched along with debrisoquin in 1 studies
*Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. [MeSH]
*Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. [MeSH]
| Studies (noralfentanil) | Trials (noralfentanil) | Recent Studies (post-2010) (noralfentanil) | Studies (debrisoquin) | Trials (debrisoquin) | Recent Studies (post-2010) (debrisoquin) |
|---|---|---|---|---|---|
| 8 | 0 | 1 | 890 | 89 | 17 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hendrickx, JJ; Heykants, JJ; Lauwers, W; Lavrijsen, KL; Meuldermans, WE; Van Dyck, DM; Van Houdt, JM; Woestenborghs, RJ | 1 |
1 other study(ies) available for noralfentanil and debrisoquin
| Article | Year |
|---|---|
Is the metabolism of alfentanil subject to debrisoquine polymorphism? A study using human liver microsomes.
Topics: Alfentanil; Chromatography, High Pressure Liquid; Debrisoquin; Fentanyl; Humans; Hydroxylation; Isoquinolines; Liver; Metabolism, Inborn Errors; Microsomes; Osmolar Concentration | 1988 |