nonachlor and 1-2-3-4-6-7-8-heptachlorodibenzodioxin

There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weight change on serum concentrations of POPs. We examined associations between self-reported weight change over 1 year and 10 years and serum concentrations of seven POPs in 1099 adults aged ≥ 40. Serum concentrations of most POPs were higher in those with long-term weight loss, whereas they were lower in those with long-term weight gain. Adjusted correlation coefficients of each POP with weight change for 10 years were -0.23 (P < 0.01) for trans-nonachlor, -0.16 (P < 0.01) for p,p'-dichlorodiphenyldichloroethylene, and -0.21 (P < 0.01) for β-hexachlorocyclohexane, -0.16 (P < 0.01) for PCB169, -0.20 (P < 0.01) for PCB180 and -0.17 (P < 0.01) for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Weight change for 1 year showed similar but weaker associations, compared with those of long-term weight changes. Although both beneficial health effects after weight loss and harmful health effects after weight gain are generally expected, changes in serum concentrations of POPs in relation to weight change may act on health in directions opposite to what we expect with weight change.

Topics: Dichlorodiphenyl Dichloroethylene; Environmental Pollutants; Female; Hexachlorocyclohexane; Humans; Hydrocarbons, Chlorinated; Male; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Risk Factors; Weight Gain; Weight Loss; Xenobiotics

Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes.. Cross-sectional associations of the serum concentrations of POPs with diabetes prevalence were investigated in 2,016 adult participants in the National Health and Nutrition Examination Survey 1999-2002. Six POPs (2,2',4,4',5,5'-hexachlorobiphenyl, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin, 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin, oxychlordane, p,p'-dichlorodiphenyltrichloroethane, and trans-nonachlor) were selected, because they were detectable in >or=80% of participants.. Compared with subjects with serum concentrations below the limit of detection, after adjustment for age, sex, race and ethnicity, poverty income ratio, BMI, and waist circumference, diabetes prevalence was strongly positively associated with lipid-adjusted serum concentrations of all six POPs. When the participants were classified according to the sum of category numbers of the six POPs, adjusted odds ratios were 1.0, 14.0, 14.7, 38.3, and 37.7 (P for trend < 0.001). The association was consistent in stratified analyses and stronger in younger participants, Mexican Americans, and obese individuals.. There were striking dose-response relations between serum concentrations of six selected POPs and the prevalence of diabetes. The strong graded association could offer a compelling challenge to future epidemiologic and toxicological research.

Topics: Adult; Aged; Black People; Body Mass Index; Chlordan; Cross-Sectional Studies; Diabetes Mellitus; Dichlorodiphenyl Dichloroethylene; Dose-Response Relationship, Drug; Environmental Exposure; Environmental Pollutants; Female; Humans; Hydrocarbons, Chlorinated; Male; Mexican Americans; Middle Aged; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; United States; White People