nobiletin has been researched along with tangeretin in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (11.43) | 18.2507 |
| 2000's | 18 (25.71) | 29.6817 |
| 2010's | 38 (54.29) | 24.3611 |
| 2020's | 6 (8.57) | 2.80 |
| Authors | Studies |
|---|---|
| Calomme, M; Cimanga, K; Cos, P; Hu, JP; Pieters, L; Van Poel, B; Vanden Berghe, D; Vlietinck, AJ; Ying, L | 1 |
| Beutler, JA; Boyd, MR; Cardellina, JH; Haemers, A; Hamel, E; Rajan, P; Roitman, JN; Vlietinck, AJ | 1 |
| Ash, K; Grohmann, K; Manthey, CL; Manthey, JA; Montanari, A | 1 |
| Matsuo, H; Morimoto, S; Ohnishi, A; Ohtani, H; Sawada, Y; Shoyama, Y; Takanaga, H; Yamada, S | 1 |
| Arcas, MC; Botía, JM; Del Río, JA; Fuster, MD; Ortuño, A | 1 |
| Komai, K; Morimoto, M; Nakano, A; Nakano, S; Ozaki, T; Tanimoto, K | 1 |
| Honda, Y; Koyabu, N; Kuwano, M; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Uchiumi, T; Ushigome, F | 1 |
| Koyabu, N; Murakami, H; Ohtani, H; Satoh, H; Sawada, Y; Tsujimoto, M; Yamashita, F | 1 |
| Dushenkov, S; Ho, CT; Lai, CS; Li, S; Lo, CY; Pan, MH | 1 |
| Akao, Y; Iinuma, M; Itoh, T; Nozawa, Y; Ohguchi, K | 1 |
| Akita, K; Fujii, M; Hirata, T; Hongo, D; Kuroyanagi, M; Ogawa, K; Yanaka, N | 1 |
| Bönisch, H; Haenisch, B; Mayer, R; Müller, CE; Müller, H; Pajeva, IK; Pick, A; Weigt, M; Wiese, M | 1 |
| Kosano, H; Miyata, Y; Natsugari, H; Okuyama, Y; Oshitari, T; Takahashi, H | 1 |
| Kosano, H; Miyata, Y; Natsugari, H; Okuyama, Y; Oshitari, T; Shimada, A; Takahashi, H | 1 |
| Alcaro, S; Ambrosio, FA; Artese, A; Bagetta, D; Catalano, R; Costa, G; Lupia, A; Maruca, A; Mesiti, F; Moraca, F; Ortuso, F; Rocca, R; Romeo, I | 1 |
| Drzewiecki, G; Kandaswami, C; Middleton, E; Perkins, E; Soloniuk, DS | 2 |
| Canada, AT; Nguyen, TD | 1 |
| Calomme, M; Pieters, L; Vanden Berghe, D; Vlietinck, A | 1 |
| Kandanearatachi, A; Pilkington, GJ; Rooprai, HK; Rucklidge, G | 1 |
| Ikegawa, T; Koyabu, N; Morimoto, S; Naito, M; Ohtani, H; Sawada, Y; Shoyama, Y; Tsuruo, T; Ushigome, F | 1 |
| Christidou, M; Dexter, DT; Kandanearatchi, A; Maidment, SL; Pilkington, GJ; Rooprai, HK; Rucklidge, GJ; Trillo-Pazos, G; Widmer, W | 1 |
| Chen, Y; Guo, MJ; Guo, XL; Wang, TJ | 1 |
| Daugherty, A; Kurowska, EM; Manthey, JA; Whitman, SC | 1 |
| Asemota, HN; Green, CO; Osagie, AU; St A Morrison, EY; Wheatley, AO | 1 |
| Ferguson, PJ; Koropatnick, J; Morley, KL | 1 |
| Hiratsuka, A; Nishimuta, H; Ogura, K; Ohtani, H; Sawada, Y; Tsujimoto, M | 1 |
| Bourland, TC; Miller, EG; Patil, BS; Peacock, JJ; Taylor, SE; Wright, JM | 1 |
| Eguchi, A; Ho, CT; Li, S; Murakami, A; Ohigashi, H | 1 |
| Liang, YZ; Xie, PS; Yi, LZ; Yuan, DL; Zhao, Y | 1 |
| Henmi, K; Hirano, T; Ishii, K; Kagami, K; Kaise, T; Tanaka, S; Toyoda, H | 1 |
| Asami, Y; Hamamoto, H; Horie, R; Sekimizu, K | 1 |
| Jiang, L; Lin, LW; Zheng, GD | 1 |
| Cesar, TB; Jackson, E; Manthey, JA; Mertens-Talcott, S | 1 |
| Ito, A; Kosano, H; Miyata, Y; Sato, T; Shimada, A; Tanaka, H; Yamanouchi, T | 1 |
| Chang, CI; Hsu, JL; Liao, MH; Lin, BW; Lin, PY; Shih, WL; Wu, HY; Yen, CH; Yu, FL | 1 |
| Dejaegher, B; Fan, G; Frédérich, M; Szandrach, A; Thierry, L; Tistaert, C; Vander Heyden, Y | 1 |
| Chang, CD; Liao, MH; Lin, PY; Shih, WL; Wu, HY; Yu, FL | 1 |
| Hirano, T; Horike, N; Onda, K; Suzuki, T | 1 |
| Cui, Y; Eun, SY; Hyun, JW; Jung, SC; Kim, SJ; Lee, SR; Maeng, YH; Park, DB; Wu, JJ; Yang, YS | 1 |
| Hirata, M; Inada, M; Matsumoto, C; Miyaura, C; Tominari, T | 1 |
| Han, HS; Lee, J; Lim, SH; Song, KS; Yang, EJ | 1 |
| Chen, J; Jiang, P; Qiao, L; Shen, Y; Sun, Y; Ye, X | 1 |
| Liao, YC; Shi, MD; Shih, YW; Tsai, LY | 1 |
| Chung, S; Han, MJ; Jang, SE; Kim, DH; Park, SH; Ryu, KR; Teruya, Y; Woo, JT | 1 |
| Chung, HY; Huang, WH; Li, GQ; Li, MM; Li, YL; Luo, HJ; Wang, GC; Wu, X; Xu, JJ; Yang, YT; Ye, WC | 1 |
| Ho, SC; Kuo, CT | 1 |
| Choi, BK; Jung, JY; Jung, WH; Kim, TW; Lee, DR; Lim, JH; Suh, JW; Yang, SH | 1 |
| Fan, G; Song, F; Wu, F; Ye, X | 1 |
| Al-Mourabit, A; Cerella, C; Dicato, M; Diederich, M; Guissou, IP; Moriou, C; Sawadogo, WR; Teiten, MH | 1 |
| Batenburg, AM; de Joode, T; Gouka, RJ | 1 |
| Bischoff, SC; Feilhauer, K; Hagenlocher, Y; Lorentz, A; Schäffer, M | 1 |
| Ikeda, R; Ito, K; Kuroda, Y; Uda, K; Wakabayashi, K; Watanabe, T; Yamazaki, T | 1 |
| Johnson, EJ; Köck, K; Paine, MF; Won, CS | 1 |
| Ahmed, T; Behzad, S; Braidy, N; Daglia, M; Habtemariam, S; Nabavi, SF; Nabavi, SM; Sobarzo-Sanchez, E | 1 |
| Chen, BZ; Duan, L; Li, P; Liu, EH; Zeng, SL | 1 |
| Hashizume, R; Masaki, H; Yoshizaki, N | 1 |
| Ho, CT; Jeong, WS; Jun, M; Lee, J; Youn, K; Yu, Y | 1 |
| Guo, R; Li, D; Ma, S; Su, J; Xiao, X; Xu, H; Yang, H; Zhang, F; Zhang, X; Zhang, Y | 1 |
| Mesquita, E; Monteiro, M | 1 |
| Matsumoto, T; Sakaguchi, I; Shigeyama, K; Shiota, H; Ueyama, T; Yamaguchi, M; Yonezawa, Y; Yoshikawa, M | 1 |
| Cao, J; Ji, S; Sun, C; Wang, Y; Zang, W | 1 |
| Ho, CT; Li, M; Li, S; Long, T; Lv, X; Xu, Y; Yang, G; Zhan, J | 1 |
| Bao, Y; DiMarco-Crook, C; Han, Y; Li, C; Lu, C; Tian, G; Xiao, H; Zhang, H; Zhao, C; Zheng, J | 1 |
| Cai, X; Huang, D; Lei, Y; Lin, M; Luo, K; Sun, Z; Tan, S; Wang, Y; Xia, X; Yan, J; Zhang, Y | 1 |
| Barreca, D; Gattuso, G; Haefeli, WE; Weiss, J | 1 |
| Kaur, A; Singh, B; Singh, JP; Singh, N | 1 |
| Nakajima, A; Nemoto, K; Ohizumi, Y | 1 |
| Huang, X; Jing, H; Kou, X; Ma, C; Wang, H; Wang, L; Zhu, J | 1 |
| Matsuzaki, K; Ohizumi, Y | 1 |
4 review(s) available for nobiletin and tangeretin
| Article | Year |
|---|---|
The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile.
Topics: Anticarcinogenic Agents; Antioxidants; Diet, Mediterranean; Fruit; Humans; Neoplasms; Olive Oil; Vegetables; Wine | 2019 |
Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease.
Topics: Alzheimer Disease; Animals; Citrus; Flavones; Flavonoids; Humans; Neuroprotective Agents; Parkinson Disease; Phytotherapy | 2017 |
Phenolic composition, antioxidant potential and health benefits of citrus peel.
Topics: Antioxidants; Biological Availability; Citrus; Coumaric Acids; Flavanones; Flavones; Fruit; Hesperidin; Hydroxybenzoates; Phenols; Plant Extracts; Polyphenols | 2020 |
Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders.
Topics: Animals; Central Nervous System Diseases; Citrus; Flavones; Humans; Inflammation; Lipopolysaccharides; Models, Animal; Multiple Sclerosis | 2021 |
66 other study(ies) available for nobiletin and tangeretin
| Article | Year |
|---|---|
Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.
Topics: Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Structure-Activity Relationship; Xanthine Oxidase | 1998 |
Structure-activity requirements for flavone cytotoxicity and binding to tubulin.
Topics: Antineoplastic Agents, Phytogenic; Biopolymers; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Flavonoids; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 1998 |
Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes.
Topics: Citrus; Cyclic AMP; Flavonoids; Humans; In Vitro Techniques; Lipopolysaccharides; Monocytes; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 1999 |
Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Caco-2 Cells; Cell Survival; Citrus; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Flavones; Flavonoids; Humans; Hydroxylation; Liver; LLC-PK1 Cells; Mixed Function Oxygenases; Solvents; Swine; Testosterone; Vinblastine | 2000 |
Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels.
Topics: Adenine; Benzyl Compounds; Citrus; Flavones; Flavonoids; Kinetin; Phytophthora; Plant Diseases; Purines | 2002 |
Insect antifeedant activity of flavones and chromones against Spodoptera litura.
Topics: Animals; Chromones; Eating; Flavonoids; Gnaphalium; Insecticides; Methylation; Spodoptera; Structure-Activity Relationship | 2003 |
Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.
Topics: Algorithms; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Citrus; Cyclosporine; Food-Drug Interactions; HIV Protease Inhibitors; Humans; Immunosuppressive Agents; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Plant Extracts; Propionates; Quinolines; Saquinavir; Transfection; Verapamil; Vinblastine | 2004 |
Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.
Topics: Beverages; Cell Line; Citrus paradisi; Citrus sinensis; Estrone; Glyburide; Humans; Organic Anion Transporters; Transfection | 2005 |
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Chromatography, High Pressure Liquid; Citrus; Flavones; Fruit; HL-60 Cells; Humans; Hydroxylation; Indicators and Reagents; Magnetic Resonance Spectroscopy; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2007 |
Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells.
Topics: Cell Line, Tumor; Cell Proliferation; Citrus; Drug Interactions; Flavones; Humans; Neuroblastoma; Phytotherapy | 2008 |
Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Antineoplastic Agents; Cell Line, Tumor; Citrus; Coumarins; Drug Evaluation, Preclinical; Flavones; Humans; Mice | 2009 |
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Flavonoids; Humans; Hydrogen Bonding; Models, Molecular; Neoplasm Proteins; Quantitative Structure-Activity Relationship | 2011 |
B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
Topics: Cell Line; Enzyme Precursors; Epithelial Cells; Flavones; Humans; Lens, Crystalline; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Protease Inhibitors; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2011 |
Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.
Topics: Cataract; Cell Line; Cell Movement; Cell Proliferation; Citrus; Epithelial Cells; Flavones; Humans; Lens, Crystalline; Matrix Metalloproteinase 9; Structure-Activity Relationship | 2013 |
Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Flavones; Flavonoids; Flavonols; Glioma; Humans; Lung; Plant Extracts; Quercetin; Tumor Cells, Cultured | 1992 |
Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Cell Line; Citrus; Drug Screening Assays, Antitumor; Flavones; Flavonoids; Flavonols; Humans; Quercetin | 1991 |
Citrus flavonoids stimulate secretion by human colonic T84 cells.
Topics: Adenocarcinoma; Carbachol; Chlorides; Citrus; Colon; Colonic Neoplasms; Cyclic AMP; Cyclic GMP; Drug Synergism; Flavanones; Flavones; Flavonoids; Glycosylation; Humans; Kinetics; Tumor Cells, Cultured | 1993 |
Inhibition of bacterial mutagenesis by Citrus flavonoids.
Topics: Anticarcinogenic Agents; Antimutagenic Agents; Antioxidants; Benzo(a)pyrene; Citrus; Diet; Flavanones; Flavones; Flavonoids; Hesperidin; Humans; Mutagenicity Tests; Mutagens; Salmonella typhimurium | 1996 |
Influence of putative antiinvasive agents on matrix metalloproteinase secretion by human neoplastic glia in vitro.
Topics: Antineoplastic Agents; Brain Neoplasms; Captopril; Collagenases; Flavones; Flavonoids; Gelatinases; Glioma; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Swainsonine; Tumor Cells, Cultured | 1999 |
Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
Topics: Acetates; ATP Binding Cassette Transporter, Subfamily B; Beverages; Blotting, Western; Citrus; Cyclosporine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavones; Flavonoids; Furocoumarins; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Plant Extracts; Tritium; Verapamil; Vincristine | 2000 |
Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Captopril; Cell Adhesion; Cell Movement; Cell Survival; Collagen; Drug Evaluation, Preclinical; Ependymoma; Flavones; Flavonoids; Glioblastoma; Humans; Inhibitory Concentration 50; Matrix Metalloproteinases; Neoplasm Invasiveness; Swainsonine; Tumor Cells, Cultured | 2001 |
[Studies on chemical constituents of processed green tangerine peel].
Topics: Acetic Acid; Citrus; Flavones; Flavonoids; Fruit; Hesperidin; Hot Temperature; Plants, Medicinal; Technology, Pharmaceutical | 2000 |
Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.
Topics: Animals; Cell Membrane; Cells, Cultured; Citrus; Flavanones; Flavones; Fruit; Hesperidin; Lipoproteins, LDL; Lipoproteins, VLDL; Macrophages; Mice; Receptors, Immunologic; Receptors, Scavenger; Scavenger Receptors, Class A | 2005 |
Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography.
Topics: Calibration; Chromatography, High Pressure Liquid; Citrus; Flavones; Flavonoids; Florida; Jamaica; Mexico; Microscopy, Ultraviolet; Molecular Structure; Species Specificity | 2007 |
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Flavones; G1 Phase; HT29 Cells; Humans; Molecular Structure; Time Factors | 2007 |
Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.
Topics: Adrenergic beta-Agonists; Arylsulfotransferase; Beverages; Biflavonoids; Biological Availability; Catechin; Citrus paradisi; Citrus sinensis; Flavanones; Flavones; Herb-Drug Interactions; Humans; In Vitro Techniques; Phenols; Polyphenols; Quercetin; Sulfotransferases; Tea | 2007 |
Inhibition of oral carcinogenesis by citrus flavonoids.
Topics: Animals; Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Citrus; Cricetinae; Flavanones; Flavones; Flavonoids; Hesperidin; Mouth Neoplasms; Random Allocation | 2008 |
Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
Topics: CD36 Antigens; Cell Line; Down-Regulation; Flavones; Gene Expression; Humans; Monocytes; NF-kappa B; Receptors, Scavenger; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2007 |
Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods.
Topics: Chromatography, High Pressure Liquid; Citrus; Flavones; Hesperidin; Medicine, Chinese Traditional; Metabolomics; Principal Component Analysis; Seasons | 2009 |
Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Daunorubicin; Drug Resistance, Neoplasm; Flavones; Flavonoids; Humans; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.
Topics: Animals; Bombyx; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Flavones; Flavonoids; Hemolymph; Mass Spectrometry; Models, Animal; Plant Extracts | 2010 |
[Study on the contents of flavonoids in Citrus reticulata 'Chachi' from various habitats and different collecting periods].
Topics: Chromatography, High Pressure Liquid; Citrus; Ecosystem; Flavones; Flavonoids; Fruit; Hesperidin; Quality Control; Reproducibility of Results; Seasons; Time Factors | 2010 |
Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Flavones; Male; Plant Extracts; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2011 |
Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin.
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Animals; Apoptosis; Blotting, Western; Cell Culture Techniques; Cell Differentiation; Cell Enlargement; Chemokine CCL2; Culture Media; Enzyme-Linked Immunosorbent Assay; Flavones; In Situ Nick-End Labeling; Insulin Resistance; Mice; Molecular Structure; Time Factors; Triglycerides | 2011 |
Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cell Line, Tumor; Flavones; Hepatocytes; Humans; Liver Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Oleanolic Acid; Signal Transduction; Trans-Activators; Transcriptional Activation; Transfection; Triterpenes; Ursolic Acid; Viral Regulatory and Accessory Proteins | 2011 |
Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination.
Topics: Chromatography, High Pressure Liquid; Citrus; Discriminant Analysis; Drugs, Chinese Herbal; Flavanones; Flavones; Hesperidin; Least-Squares Analysis; Polymerase Chain Reaction; Quality Control | 2011 |
Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Proliferation; Cisplatin; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flavones; Fluorescent Antibody Technique; Glucose-6-Phosphate Isomerase; Humans; Immunoprecipitation; Liver Neoplasms; Luciferases; Lung Neoplasms; Male; Matrix Metalloproteinase 3; Mice; Mice, Nude; Neovascularization, Pathologic; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2013 |
Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flavones; Glucose; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2013 |
Mild mitochondrial depolarization is involved in a neuroprotective mechanism of Citrus sunki peel extract.
Topics: Apoptosis; Calcium; Cell Line; Citrus; Flavones; Flow Cytometry; Fruit; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neuroprotective Agents; Plant Extracts | 2013 |
Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Cell Differentiation; Cell Line; Cells, Cultured; Disease Models, Animal; Flavones; Lipopolysaccharides; Mandibular Diseases; Mice; Osteoclasts; Periodontitis | 2012 |
Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; Citrus; Disease Models, Animal; DNA Fragmentation; Flavones; Fruit; Hep G2 Cells; Humans; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2013 |
Phytochemical profile and antioxidant activity of physiological drop of citrus fruits.
Topics: Antioxidants; China; Citrus; Coumaric Acids; Dietary Supplements; Disaccharides; Flavanones; Flavones; Fruit; Hesperidin; Hydroxybenzoates; Limonins; Plant Extracts; Synephrine | 2013 |
Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells.
Topics: Apigenin; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Survival; Chromones; Flavones; Hep G2 Cells; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pseudopodia | 2013 |
Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Cell Line, Tumor; Flavones; Histamine; Interleukin-4; Male; Mice; Mice, Inbred ICR; NF-kappa B; p-Methoxy-N-methylphenethylamine; p38 Mitogen-Activated Protein Kinases; Pruritus; Skin; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2013 |
Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi'.
Topics: Antiviral Agents; Cell Line; Citrus; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flavones; Humans; Plant Extracts; Plants, Medicinal; Respiratory Syncytial Viruses; Viral Structural Proteins; Virus Attachment | 2014 |
Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium).
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromatography, High Pressure Liquid; Citrus; Flavones; Hesperidin; Microglia; Plant Extracts; Spectrometry, Mass, Electrospray Ionization | 2014 |
A polymethoxy flavonoids-rich Citrus aurantium extract ameliorates ethanol-induced liver injury through modulation of AMPK and Nrf2-related signals in a binge drinking mouse model.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Binge Drinking; Citrus; Disease Models, Animal; Ethanol; Flavones; Flavonoids; Heme Oxygenase-1; Inflammation; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Plant Extracts; Silymarin; Tumor Necrosis Factor-alpha | 2015 |
[Simultaneous determination of 11 constituents in Citrus reticulate 'Chachi' by high performance liquid chromatography].
Topics: Apigenin; Chromatography, High Pressure Liquid; Citrus; Flavones; Flavonoids; Furaldehyde; Glucosides; Hesperidin | 2015 |
Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3',4',5'-Pentamethoxyflavone Isolated from Lantana ukambensis.
Topics: Apoptosis; Cell Proliferation; Cell Survival; Flavones; Flavonoids; Humans; Jurkat Cells; K562 Cells; Lantana; Leukocytes, Mononuclear; Plant Extracts; Plants, Medicinal; U937 Cells | 2015 |
Characterization and Modulation of the Bitterness of Polymethoxyflavones Using Sensory and Receptor-Based Methods.
Topics: Chromatography, High Pressure Liquid; Citrus; Flavones; Flavoring Agents; Molecular Structure; Polyphenols; Receptors, G-Protein-Coupled; Taste | 2016 |
Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells.
Topics: Anti-Inflammatory Agents; beta-N-Acetylhexosaminidases; Cells, Cultured; Citrus; Cytokines; Flavones; Flavonoids; Humans; Immunoglobulin E; Intestinal Mucosa; Intestines; Lipopolysaccharides; Mast Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Plant Extracts | 2017 |
Activation of human bitter taste receptors by polymethoxylated flavonoids.
Topics: Flavones; HEK293 Cells; Humans; Receptors, G-Protein-Coupled | 2016 |
Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice.
Topics: Animals; Cells, Cultured; Citrus paradisi; Computer Simulation; Dogs; Estrone; Flavanones; Flavones; Food-Drug Interactions; Fruit and Vegetable Juices; Furocoumarins; Hesperidin; Humans; Inhibitory Concentration 50; Models, Biological; Organic Anion Transporters | 2017 |
Chemicalome and metabolome profiling of polymethoxylated flavonoids in Citri Reticulatae Pericarpium based on an integrated strategy combining background subtraction and modified mass defect filter in a Microsoft Excel Platform.
Topics: Animals; Chromatography, High Pressure Liquid; Citrus; Data Mining; Drugs, Chinese Herbal; Flavones; Flavonoids; Male; Mass Spectrometry; Metabolome; Metabolomics; Molecular Weight; Rats; Rats, Sprague-Dawley | 2017 |
A polymethoxyflavone mixture extracted from orange peels, mainly containing nobiletin, 3,3',4',5,6,7,8-heptamethoxyflavone and tangeretin, suppresses melanogenesis through the acidification of cell organelles, including melanosomes.
Topics: Cell Line, Tumor; Citrus sinensis; Flavones; Flavonoids; Humans; Hydrogen-Ion Concentration; Lysosomes; Melanins; Melanosomes; Monophenol Monooxygenase; Plant Extracts | 2017 |
Polymethoxyflavones: Novel β-Secretase (BACE1) Inhibitors from Citrus Peels.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Citrus; Dose-Response Relationship, Drug; Flavones; Flavonoids; Fruit; Humans; Hydrogen Bonding; Kinetics; Molecular Docking Simulation; Protease Inhibitors; Protein Binding; Protein Conformation; Structure-Activity Relationship | 2017 |
Identifying potential quality markers of Xin-Su-Ning capsules acting on arrhythmia by integrating UHPLC-LTQ-Orbitrap, ADME prediction and network target analysis.
Topics: Alkaloids; Arrhythmias, Cardiac; Biological Availability; Capsules; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Flavones; Flavonoids; Humans; Medicine, Chinese Traditional; Quality Control; Spectrometry, Mass, Electrospray Ionization | 2018 |
Simultaneous HPLC determination of flavonoids and phenolic acids profile in Pêra-Rio orange juice.
Topics: Chromatography, High Pressure Liquid; Citrus sinensis; Disaccharides; Flavanones; Flavones; Flavonoids; Food Analysis; Fruit; Fruit and Vegetable Juices; Hesperidin; Humans; Phenols; Reproducibility of Results | 2018 |
Effects of Cultivation Month and Genetic Background on Phenolic Content of Citrus tachibana Peel.
Topics: Agriculture; Citrus; Flavones; Fruit; Genetic Background; Hesperidin; Phenols; Seasons | 2018 |
Three Polymethoxyflavones Purified from Ougan (
Topics: Animals; Cell Line; Cell Survival; Citrus; Flavones; Lipopolysaccharides; Mice; Microglia; Molecular Structure; Nitric Oxide | 2019 |
Simultaneous separation of six pure polymethoxyflavones from sweet orange peel extract by high performance counter current chromatography.
Topics: Chromatography, High Pressure Liquid; Citrus sinensis; Countercurrent Distribution; Flavones; Flavonoids; Humans; Plant Extracts; Spectrometry, Mass, Electrospray Ionization | 2019 |
Characterization of polymethoxyflavone demethylation during drying processes of citrus peels.
Topics: Citrus; Demethylation; Desiccation; Flavones; Flavonoids; Food Handling; Fruit; Plant Extracts | 2019 |
Quantitative analysis of multicomponents by single marker combined with HPLC fingerprint qualitative analyses for comprehensive evaluation of Aurantii Fructus.
Topics: Chromatography, High Pressure Liquid; Citrus; Coumarins; Disaccharides; Flavanones; Flavones; Flavonoids; Fruit; Hesperidin | 2020 |
Nobiletin, sinensetin, and tangeretin are the main perpetrators in clementines provoking food-drug interactions in vitro.
Topics: ATP Binding Cassette Transporter, Subfamily B; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Citrus; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Flavones; Flavonoids; Food-Drug Interactions; Fruit; Gene Expression Regulation; Humans; Peroxisome-Targeting Signal 1 Receptor; Receptors, Aryl Hydrocarbon | 2020 |
An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar 'Ohta ponkan' (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity.
Topics: Administration, Oral; Alzheimer Disease; Animals; Body Weight; Chromosome Aberrations; Citrus; Dose-Response Relationship, Drug; Female; Flavones; Functional Food; Male; Micronucleus Tests; Nootropic Agents; Parkinson Disease; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2020 |
Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation.
Topics: Animals; Citrus; Flavones; Fruit; Kinetics; Lipase; Molecular Docking Simulation; Molecular Dynamics Simulation; Pancreas; Plant Extracts; Swine | 2020 |