Page last updated: 2024-08-25

nobiletin and tangeretin

nobiletin has been researched along with tangeretin in 70 studies

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (11.43)18.2507
2000's18 (25.71)29.6817
2010's38 (54.29)24.3611
2020's6 (8.57)2.80

Authors

AuthorsStudies
Calomme, M; Cimanga, K; Cos, P; Hu, JP; Pieters, L; Van Poel, B; Vanden Berghe, D; Vlietinck, AJ; Ying, L1
Beutler, JA; Boyd, MR; Cardellina, JH; Haemers, A; Hamel, E; Rajan, P; Roitman, JN; Vlietinck, AJ1
Ash, K; Grohmann, K; Manthey, CL; Manthey, JA; Montanari, A1
Matsuo, H; Morimoto, S; Ohnishi, A; Ohtani, H; Sawada, Y; Shoyama, Y; Takanaga, H; Yamada, S1
Arcas, MC; Botía, JM; Del Río, JA; Fuster, MD; Ortuño, A1
Komai, K; Morimoto, M; Nakano, A; Nakano, S; Ozaki, T; Tanimoto, K1
Honda, Y; Koyabu, N; Kuwano, M; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Uchiumi, T; Ushigome, F1
Koyabu, N; Murakami, H; Ohtani, H; Satoh, H; Sawada, Y; Tsujimoto, M; Yamashita, F1
Dushenkov, S; Ho, CT; Lai, CS; Li, S; Lo, CY; Pan, MH1
Akao, Y; Iinuma, M; Itoh, T; Nozawa, Y; Ohguchi, K1
Akita, K; Fujii, M; Hirata, T; Hongo, D; Kuroyanagi, M; Ogawa, K; Yanaka, N1
Bönisch, H; Haenisch, B; Mayer, R; Müller, CE; Müller, H; Pajeva, IK; Pick, A; Weigt, M; Wiese, M1
Kosano, H; Miyata, Y; Natsugari, H; Okuyama, Y; Oshitari, T; Takahashi, H1
Kosano, H; Miyata, Y; Natsugari, H; Okuyama, Y; Oshitari, T; Shimada, A; Takahashi, H1
Alcaro, S; Ambrosio, FA; Artese, A; Bagetta, D; Catalano, R; Costa, G; Lupia, A; Maruca, A; Mesiti, F; Moraca, F; Ortuso, F; Rocca, R; Romeo, I1
Drzewiecki, G; Kandaswami, C; Middleton, E; Perkins, E; Soloniuk, DS2
Canada, AT; Nguyen, TD1
Calomme, M; Pieters, L; Vanden Berghe, D; Vlietinck, A1
Kandanearatachi, A; Pilkington, GJ; Rooprai, HK; Rucklidge, G1
Ikegawa, T; Koyabu, N; Morimoto, S; Naito, M; Ohtani, H; Sawada, Y; Shoyama, Y; Tsuruo, T; Ushigome, F1
Christidou, M; Dexter, DT; Kandanearatchi, A; Maidment, SL; Pilkington, GJ; Rooprai, HK; Rucklidge, GJ; Trillo-Pazos, G; Widmer, W1
Chen, Y; Guo, MJ; Guo, XL; Wang, TJ1
Daugherty, A; Kurowska, EM; Manthey, JA; Whitman, SC1
Asemota, HN; Green, CO; Osagie, AU; St A Morrison, EY; Wheatley, AO1
Ferguson, PJ; Koropatnick, J; Morley, KL1
Hiratsuka, A; Nishimuta, H; Ogura, K; Ohtani, H; Sawada, Y; Tsujimoto, M1
Bourland, TC; Miller, EG; Patil, BS; Peacock, JJ; Taylor, SE; Wright, JM1
Eguchi, A; Ho, CT; Li, S; Murakami, A; Ohigashi, H1
Liang, YZ; Xie, PS; Yi, LZ; Yuan, DL; Zhao, Y1
Henmi, K; Hirano, T; Ishii, K; Kagami, K; Kaise, T; Tanaka, S; Toyoda, H1
Asami, Y; Hamamoto, H; Horie, R; Sekimizu, K1
Jiang, L; Lin, LW; Zheng, GD1
Cesar, TB; Jackson, E; Manthey, JA; Mertens-Talcott, S1
Ito, A; Kosano, H; Miyata, Y; Sato, T; Shimada, A; Tanaka, H; Yamanouchi, T1
Chang, CI; Hsu, JL; Liao, MH; Lin, BW; Lin, PY; Shih, WL; Wu, HY; Yen, CH; Yu, FL1
Dejaegher, B; Fan, G; Frédérich, M; Szandrach, A; Thierry, L; Tistaert, C; Vander Heyden, Y1
Chang, CD; Liao, MH; Lin, PY; Shih, WL; Wu, HY; Yu, FL1
Hirano, T; Horike, N; Onda, K; Suzuki, T1
Cui, Y; Eun, SY; Hyun, JW; Jung, SC; Kim, SJ; Lee, SR; Maeng, YH; Park, DB; Wu, JJ; Yang, YS1
Hirata, M; Inada, M; Matsumoto, C; Miyaura, C; Tominari, T1
Han, HS; Lee, J; Lim, SH; Song, KS; Yang, EJ1
Chen, J; Jiang, P; Qiao, L; Shen, Y; Sun, Y; Ye, X1
Liao, YC; Shi, MD; Shih, YW; Tsai, LY1
Chung, S; Han, MJ; Jang, SE; Kim, DH; Park, SH; Ryu, KR; Teruya, Y; Woo, JT1
Chung, HY; Huang, WH; Li, GQ; Li, MM; Li, YL; Luo, HJ; Wang, GC; Wu, X; Xu, JJ; Yang, YT; Ye, WC1
Ho, SC; Kuo, CT1
Choi, BK; Jung, JY; Jung, WH; Kim, TW; Lee, DR; Lim, JH; Suh, JW; Yang, SH1
Fan, G; Song, F; Wu, F; Ye, X1
Al-Mourabit, A; Cerella, C; Dicato, M; Diederich, M; Guissou, IP; Moriou, C; Sawadogo, WR; Teiten, MH1
Batenburg, AM; de Joode, T; Gouka, RJ1
Bischoff, SC; Feilhauer, K; Hagenlocher, Y; Lorentz, A; Schäffer, M1
Ikeda, R; Ito, K; Kuroda, Y; Uda, K; Wakabayashi, K; Watanabe, T; Yamazaki, T1
Johnson, EJ; Köck, K; Paine, MF; Won, CS1
Ahmed, T; Behzad, S; Braidy, N; Daglia, M; Habtemariam, S; Nabavi, SF; Nabavi, SM; Sobarzo-Sanchez, E1
Chen, BZ; Duan, L; Li, P; Liu, EH; Zeng, SL1
Hashizume, R; Masaki, H; Yoshizaki, N1
Ho, CT; Jeong, WS; Jun, M; Lee, J; Youn, K; Yu, Y1
Guo, R; Li, D; Ma, S; Su, J; Xiao, X; Xu, H; Yang, H; Zhang, F; Zhang, X; Zhang, Y1
Mesquita, E; Monteiro, M1
Matsumoto, T; Sakaguchi, I; Shigeyama, K; Shiota, H; Ueyama, T; Yamaguchi, M; Yonezawa, Y; Yoshikawa, M1
Cao, J; Ji, S; Sun, C; Wang, Y; Zang, W1
Ho, CT; Li, M; Li, S; Long, T; Lv, X; Xu, Y; Yang, G; Zhan, J1
Bao, Y; DiMarco-Crook, C; Han, Y; Li, C; Lu, C; Tian, G; Xiao, H; Zhang, H; Zhao, C; Zheng, J1
Cai, X; Huang, D; Lei, Y; Lin, M; Luo, K; Sun, Z; Tan, S; Wang, Y; Xia, X; Yan, J; Zhang, Y1
Barreca, D; Gattuso, G; Haefeli, WE; Weiss, J1
Kaur, A; Singh, B; Singh, JP; Singh, N1
Nakajima, A; Nemoto, K; Ohizumi, Y1
Huang, X; Jing, H; Kou, X; Ma, C; Wang, H; Wang, L; Zhu, J1
Matsuzaki, K; Ohizumi, Y1

Reviews

4 review(s) available for nobiletin and tangeretin

ArticleYear
The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile.
    European journal of medicinal chemistry, 2019, Nov-01, Volume: 181

    Topics: Anticarcinogenic Agents; Antioxidants; Diet, Mediterranean; Fruit; Humans; Neoplasms; Olive Oil; Vegetables; Wine

2019
Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease.
    CNS & neurological disorders drug targets, 2017, Volume: 16, Issue:4

    Topics: Alzheimer Disease; Animals; Citrus; Flavones; Flavonoids; Humans; Neuroprotective Agents; Parkinson Disease; Phytotherapy

2017
Phenolic composition, antioxidant potential and health benefits of citrus peel.
    Food research international (Ottawa, Ont.), 2020, Volume: 132

    Topics: Antioxidants; Biological Availability; Citrus; Coumaric Acids; Flavanones; Flavones; Fruit; Hesperidin; Hydroxybenzoates; Phenols; Plant Extracts; Polyphenols

2020
Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders.
    Nutrients, 2021, Jan-04, Volume: 13, Issue:1

    Topics: Animals; Central Nervous System Diseases; Citrus; Flavones; Humans; Inflammation; Lipopolysaccharides; Models, Animal; Multiple Sclerosis

2021

Other Studies

66 other study(ies) available for nobiletin and tangeretin

ArticleYear
Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.
    Journal of natural products, 1998, Volume: 61, Issue:1

    Topics: Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Structure-Activity Relationship; Xanthine Oxidase

1998
Structure-activity requirements for flavone cytotoxicity and binding to tubulin.
    Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13

    Topics: Antineoplastic Agents, Phytogenic; Biopolymers; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Flavonoids; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured

1998
Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes.
    Journal of natural products, 1999, Volume: 62, Issue:3

    Topics: Citrus; Cyclic AMP; Flavonoids; Humans; In Vitro Techniques; Lipopolysaccharides; Monocytes; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

1999
Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Caco-2 Cells; Cell Survival; Citrus; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Flavones; Flavonoids; Humans; Hydroxylation; Liver; LLC-PK1 Cells; Mixed Function Oxygenases; Solvents; Swine; Testosterone; Vinblastine

2000
Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels.
    Journal of agricultural and food chemistry, 2002, May-08, Volume: 50, Issue:10

    Topics: Adenine; Benzyl Compounds; Citrus; Flavones; Flavonoids; Kinetin; Phytophthora; Plant Diseases; Purines

2002
Insect antifeedant activity of flavones and chromones against Spodoptera litura.
    Journal of agricultural and food chemistry, 2003, Jan-15, Volume: 51, Issue:2

    Topics: Animals; Chromones; Eating; Flavonoids; Gnaphalium; Insecticides; Methylation; Spodoptera; Structure-Activity Relationship

2003
Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.
    British journal of pharmacology, 2004, Volume: 143, Issue:7

    Topics: Algorithms; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Citrus; Cyclosporine; Food-Drug Interactions; HIV Protease Inhibitors; Humans; Immunosuppressive Agents; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Plant Extracts; Propionates; Quinolines; Saquinavir; Transfection; Verapamil; Vinblastine

2004
Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:4

    Topics: Beverages; Cell Line; Citrus paradisi; Citrus sinensis; Estrone; Glyburide; Humans; Organic Anion Transporters; Transfection

2005
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
    Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Chromatography, High Pressure Liquid; Citrus; Flavones; Fruit; HL-60 Cells; Humans; Hydroxylation; Indicators and Reagents; Magnetic Resonance Spectroscopy; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet

2007
Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells.
    Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6

    Topics: Cell Line, Tumor; Cell Proliferation; Citrus; Drug Interactions; Flavones; Humans; Neuroblastoma; Phytotherapy

2008
Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.
    Bioorganic & medicinal chemistry, 2009, Jan-01, Volume: 17, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Antineoplastic Agents; Cell Line, Tumor; Citrus; Coumarins; Drug Evaluation, Preclinical; Flavones; Humans; Mice

2009
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
    Bioorganic & medicinal chemistry, 2011, Mar-15, Volume: 19, Issue:6

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Flavonoids; Humans; Hydrogen Bonding; Models, Molecular; Neoplasm Proteins; Quantitative Structure-Activity Relationship

2011
B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
    Bioorganic & medicinal chemistry, 2011, Dec-01, Volume: 19, Issue:23

    Topics: Cell Line; Enzyme Precursors; Epithelial Cells; Flavones; Humans; Lens, Crystalline; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Protease Inhibitors; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2011
Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.
    Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1

    Topics: Cataract; Cell Line; Cell Movement; Cell Proliferation; Citrus; Epithelial Cells; Flavones; Humans; Lens, Crystalline; Matrix Metalloproteinase 9; Structure-Activity Relationship

2013
Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids.
    Anti-cancer drugs, 1992, Volume: 3, Issue:5

    Topics: Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Flavones; Flavonoids; Flavonols; Glioma; Humans; Lung; Plant Extracts; Quercetin; Tumor Cells, Cultured

1992
Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro.
    Cancer letters, 1991, Volume: 56, Issue:2

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Cell Line; Citrus; Drug Screening Assays, Antitumor; Flavones; Flavonoids; Flavonols; Humans; Quercetin

1991
Citrus flavonoids stimulate secretion by human colonic T84 cells.
    The Journal of nutrition, 1993, Volume: 123, Issue:2

    Topics: Adenocarcinoma; Carbachol; Chlorides; Citrus; Colon; Colonic Neoplasms; Cyclic AMP; Cyclic GMP; Drug Synergism; Flavanones; Flavones; Flavonoids; Glycosylation; Humans; Kinetics; Tumor Cells, Cultured

1993
Inhibition of bacterial mutagenesis by Citrus flavonoids.
    Planta medica, 1996, Volume: 62, Issue:3

    Topics: Anticarcinogenic Agents; Antimutagenic Agents; Antioxidants; Benzo(a)pyrene; Citrus; Diet; Flavanones; Flavones; Flavonoids; Hesperidin; Humans; Mutagenicity Tests; Mutagens; Salmonella typhimurium

1996
Influence of putative antiinvasive agents on matrix metalloproteinase secretion by human neoplastic glia in vitro.
    Annals of the New York Academy of Sciences, 1999, Jun-30, Volume: 878

    Topics: Antineoplastic Agents; Brain Neoplasms; Captopril; Collagenases; Flavones; Flavonoids; Gelatinases; Glioma; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Swainsonine; Tumor Cells, Cultured

1999
Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
    Cancer letters, 2000, Nov-10, Volume: 160, Issue:1

    Topics: Acetates; ATP Binding Cassette Transporter, Subfamily B; Beverages; Blotting, Western; Citrus; Cyclosporine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavones; Flavonoids; Furocoumarins; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Plant Extracts; Tritium; Verapamil; Vincristine

2000
Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro.
    Neuropathology and applied neurobiology, 2001, Volume: 27, Issue:1

    Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Captopril; Cell Adhesion; Cell Movement; Cell Survival; Collagen; Drug Evaluation, Preclinical; Ependymoma; Flavones; Flavonoids; Glioblastoma; Humans; Inhibitory Concentration 50; Matrix Metalloproteinases; Neoplasm Invasiveness; Swainsonine; Tumor Cells, Cultured

2001
[Studies on chemical constituents of processed green tangerine peel].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2000, Volume: 25, Issue:3

    Topics: Acetic Acid; Citrus; Flavones; Flavonoids; Fruit; Hesperidin; Hot Temperature; Plants, Medicinal; Technology, Pharmaceutical

2000
Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.
    Atherosclerosis, 2005, Volume: 178, Issue:1

    Topics: Animals; Cell Membrane; Cells, Cultured; Citrus; Flavanones; Flavones; Fruit; Hesperidin; Lipoproteins, LDL; Lipoproteins, VLDL; Macrophages; Mice; Receptors, Immunologic; Receptors, Scavenger; Scavenger Receptors, Class A

2005
Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography.
    Biomedical chromatography : BMC, 2007, Volume: 21, Issue:1

    Topics: Calibration; Chromatography, High Pressure Liquid; Citrus; Flavones; Flavonoids; Florida; Jamaica; Mexico; Microscopy, Ultraviolet; Molecular Structure; Species Specificity

2007
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells.
    Cancer letters, 2007, Jun-18, Volume: 251, Issue:1

    Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Flavones; G1 Phase; HT29 Cells; Humans; Molecular Structure; Time Factors

2007
Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.
    Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:9

    Topics: Adrenergic beta-Agonists; Arylsulfotransferase; Beverages; Biflavonoids; Biological Availability; Catechin; Citrus paradisi; Citrus sinensis; Flavanones; Flavones; Herb-Drug Interactions; Humans; In Vitro Techniques; Phenols; Polyphenols; Quercetin; Sulfotransferases; Tea

2007
Inhibition of oral carcinogenesis by citrus flavonoids.
    Nutrition and cancer, 2008, Volume: 60, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Citrus; Cricetinae; Flavanones; Flavones; Flavonoids; Hesperidin; Mouth Neoplasms; Random Allocation

2008
Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
    BioFactors (Oxford, England), 2007, Volume: 31, Issue:2

    Topics: CD36 Antigens; Cell Line; Down-Regulation; Flavones; Gene Expression; Humans; Monocytes; NF-kappa B; Receptors, Scavenger; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

2007
Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods.
    Analytica chimica acta, 2009, Sep-01, Volume: 649, Issue:1

    Topics: Chromatography, High Pressure Liquid; Citrus; Flavones; Hesperidin; Medicine, Chinese Traditional; Metabolomics; Principal Component Analysis; Seasons

2009
Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells.
    Cancer investigation, 2010, Volume: 28, Issue:3

    Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Daunorubicin; Drug Resistance, Neoplasm; Flavones; Flavonoids; Humans; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

2010
Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.
    BMC pharmacology, 2010, Jun-11, Volume: 10

    Topics: Animals; Bombyx; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Flavones; Flavonoids; Hemolymph; Mass Spectrometry; Models, Animal; Plant Extracts

2010
[Study on the contents of flavonoids in Citrus reticulata 'Chachi' from various habitats and different collecting periods].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2010, Volume: 33, Issue:2

    Topics: Chromatography, High Pressure Liquid; Citrus; Ecosystem; Flavones; Flavonoids; Fruit; Hesperidin; Quality Control; Reproducibility of Results; Seasons; Time Factors

2010
Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry.
    Journal of agricultural and food chemistry, 2011, Jan-12, Volume: 59, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Flavones; Male; Plant Extracts; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization

2011
Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin.
    Life sciences, 2011, Mar-28, Volume: 88, Issue:13-14

    Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Animals; Apoptosis; Blotting, Western; Cell Culture Techniques; Cell Differentiation; Cell Enlargement; Chemokine CCL2; Culture Media; Enzyme-Linked Immunosorbent Assay; Flavones; In Situ Nick-End Labeling; Insulin Resistance; Mice; Molecular Structure; Time Factors; Triglycerides

2011
Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid.
    Journal of agricultural and food chemistry, 2011, Mar-09, Volume: 59, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cell Line, Tumor; Flavones; Hepatocytes; Humans; Liver Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Oleanolic Acid; Signal Transduction; Trans-Activators; Transcriptional Activation; Transfection; Triterpenes; Ursolic Acid; Viral Regulatory and Accessory Proteins

2011
Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination.
    Analytica chimica acta, 2011, Oct-31, Volume: 705, Issue:1-2

    Topics: Chromatography, High Pressure Liquid; Citrus; Discriminant Analysis; Drugs, Chinese Herbal; Flavanones; Flavones; Hesperidin; Least-Squares Analysis; Polymerase Chain Reaction; Quality Control

2011
Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.
    Molecular carcinogenesis, 2013, Volume: 52, Issue:10

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Proliferation; Cisplatin; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flavones; Fluorescent Antibody Technique; Glucose-6-Phosphate Isomerase; Humans; Immunoprecipitation; Liver Neoplasms; Luciferases; Lung Neoplasms; Male; Matrix Metalloproteinase 3; Mice; Mice, Nude; Neovascularization, Pathologic; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta; Triterpenes; Tumor Cells, Cultured; Ursolic Acid

2013
Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes.
    Phytotherapy research : PTR, 2013, Volume: 27, Issue:2

    Topics: 3T3 Cells; Adipocytes; Animals; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flavones; Glucose; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction

2013
Mild mitochondrial depolarization is involved in a neuroprotective mechanism of Citrus sunki peel extract.
    Phytotherapy research : PTR, 2013, Volume: 27, Issue:4

    Topics: Apoptosis; Calcium; Cell Line; Citrus; Flavones; Flow Cytometry; Fruit; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neuroprotective Agents; Plant Extracts

2013
Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis.
    Journal of pharmacological sciences, 2012, Volume: 119, Issue:4

    Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Cell Differentiation; Cell Line; Cells, Cultured; Disease Models, Animal; Flavones; Lipopolysaccharides; Mandibular Diseases; Mice; Osteoclasts; Periodontitis

2012
Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion.
    Food chemistry, 2013, May-01, Volume: 138, Issue:1

    Topics: Animals; Apoptosis; Brain Ischemia; Citrus; Disease Models, Animal; DNA Fragmentation; Flavones; Fruit; Hep G2 Cells; Humans; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2013
Phytochemical profile and antioxidant activity of physiological drop of citrus fruits.
    Journal of food science, 2013, Volume: 78, Issue:1

    Topics: Antioxidants; China; Citrus; Coumaric Acids; Dietary Supplements; Disaccharides; Flavanones; Flavones; Fruit; Hesperidin; Hydroxybenzoates; Limonins; Plant Extracts; Synephrine

2013
Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Jun-15, Volume: 20, Issue:8-9

    Topics: Apigenin; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Survival; Chromones; Flavones; Hep G2 Cells; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pseudopodia

2013
Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38.
    International immunopharmacology, 2013, Volume: 17, Issue:3

    Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Cell Line, Tumor; Flavones; Histamine; Interleukin-4; Male; Mice; Mice, Inbred ICR; NF-kappa B; p-Methoxy-N-methylphenethylamine; p38 Mitogen-Activated Protein Kinases; Pruritus; Skin; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2013
Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi'.
    Journal of agricultural and food chemistry, 2014, Mar-12, Volume: 62, Issue:10

    Topics: Antiviral Agents; Cell Line; Citrus; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flavones; Humans; Plant Extracts; Plants, Medicinal; Respiratory Syncytial Viruses; Viral Structural Proteins; Virus Attachment

2014
Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium).
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 71

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromatography, High Pressure Liquid; Citrus; Flavones; Hesperidin; Microglia; Plant Extracts; Spectrometry, Mass, Electrospray Ionization

2014
A polymethoxy flavonoids-rich Citrus aurantium extract ameliorates ethanol-induced liver injury through modulation of AMPK and Nrf2-related signals in a binge drinking mouse model.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:10

    Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Binge Drinking; Citrus; Disease Models, Animal; Ethanol; Flavones; Flavonoids; Heme Oxygenase-1; Inflammation; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Plant Extracts; Silymarin; Tumor Necrosis Factor-alpha

2015
[Simultaneous determination of 11 constituents in Citrus reticulate 'Chachi' by high performance liquid chromatography].
    Se pu = Chinese journal of chromatography, 2015, Volume: 33, Issue:4

    Topics: Apigenin; Chromatography, High Pressure Liquid; Citrus; Flavones; Flavonoids; Furaldehyde; Glucosides; Hesperidin

2015
Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3',4',5'-Pentamethoxyflavone Isolated from Lantana ukambensis.
    Nutrients, 2015, Dec-10, Volume: 7, Issue:12

    Topics: Apoptosis; Cell Proliferation; Cell Survival; Flavones; Flavonoids; Humans; Jurkat Cells; K562 Cells; Lantana; Leukocytes, Mononuclear; Plant Extracts; Plants, Medicinal; U937 Cells

2015
Characterization and Modulation of the Bitterness of Polymethoxyflavones Using Sensory and Receptor-Based Methods.
    Journal of agricultural and food chemistry, 2016, Mar-30, Volume: 64, Issue:12

    Topics: Chromatography, High Pressure Liquid; Citrus; Flavones; Flavoring Agents; Molecular Structure; Polyphenols; Receptors, G-Protein-Coupled; Taste

2016
Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells.
    European journal of nutrition, 2017, Volume: 56, Issue:4

    Topics: Anti-Inflammatory Agents; beta-N-Acetylhexosaminidases; Cells, Cultured; Citrus; Cytokines; Flavones; Flavonoids; Humans; Immunoglobulin E; Intestinal Mucosa; Intestines; Lipopolysaccharides; Mast Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Plant Extracts

2017
Activation of human bitter taste receptors by polymethoxylated flavonoids.
    Bioscience, biotechnology, and biochemistry, 2016, Volume: 80, Issue:10

    Topics: Flavones; HEK293 Cells; Humans; Receptors, G-Protein-Coupled

2016
Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice.
    Biopharmaceutics & drug disposition, 2017, Volume: 38, Issue:3

    Topics: Animals; Cells, Cultured; Citrus paradisi; Computer Simulation; Dogs; Estrone; Flavanones; Flavones; Food-Drug Interactions; Fruit and Vegetable Juices; Furocoumarins; Hesperidin; Humans; Inhibitory Concentration 50; Models, Biological; Organic Anion Transporters

2017
Chemicalome and metabolome profiling of polymethoxylated flavonoids in Citri Reticulatae Pericarpium based on an integrated strategy combining background subtraction and modified mass defect filter in a Microsoft Excel Platform.
    Journal of chromatography. A, 2017, Jul-28, Volume: 1508

    Topics: Animals; Chromatography, High Pressure Liquid; Citrus; Data Mining; Drugs, Chinese Herbal; Flavones; Flavonoids; Male; Mass Spectrometry; Metabolome; Metabolomics; Molecular Weight; Rats; Rats, Sprague-Dawley

2017
A polymethoxyflavone mixture extracted from orange peels, mainly containing nobiletin, 3,3',4',5,6,7,8-heptamethoxyflavone and tangeretin, suppresses melanogenesis through the acidification of cell organelles, including melanosomes.
    Journal of dermatological science, 2017, Volume: 88, Issue:1

    Topics: Cell Line, Tumor; Citrus sinensis; Flavones; Flavonoids; Humans; Hydrogen-Ion Concentration; Lysosomes; Melanins; Melanosomes; Monophenol Monooxygenase; Plant Extracts

2017
Polymethoxyflavones: Novel β-Secretase (BACE1) Inhibitors from Citrus Peels.
    Nutrients, 2017, Sep-04, Volume: 9, Issue:9

    Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Citrus; Dose-Response Relationship, Drug; Flavones; Flavonoids; Fruit; Humans; Hydrogen Bonding; Kinetics; Molecular Docking Simulation; Protease Inhibitors; Protein Binding; Protein Conformation; Structure-Activity Relationship

2017
Identifying potential quality markers of Xin-Su-Ning capsules acting on arrhythmia by integrating UHPLC-LTQ-Orbitrap, ADME prediction and network target analysis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, May-15, Volume: 44

    Topics: Alkaloids; Arrhythmias, Cardiac; Biological Availability; Capsules; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Flavones; Flavonoids; Humans; Medicine, Chinese Traditional; Quality Control; Spectrometry, Mass, Electrospray Ionization

2018
Simultaneous HPLC determination of flavonoids and phenolic acids profile in Pêra-Rio orange juice.
    Food research international (Ottawa, Ont.), 2018, Volume: 106

    Topics: Chromatography, High Pressure Liquid; Citrus sinensis; Disaccharides; Flavanones; Flavones; Flavonoids; Food Analysis; Fruit; Fruit and Vegetable Juices; Hesperidin; Humans; Phenols; Reproducibility of Results

2018
Effects of Cultivation Month and Genetic Background on Phenolic Content of Citrus tachibana Peel.
    Biological & pharmaceutical bulletin, 2018, Volume: 41, Issue:8

    Topics: Agriculture; Citrus; Flavones; Fruit; Genetic Background; Hesperidin; Phenols; Seasons

2018
Three Polymethoxyflavones Purified from Ougan (
    Nutrients, 2019, Apr-05, Volume: 11, Issue:4

    Topics: Animals; Cell Line; Cell Survival; Citrus; Flavones; Lipopolysaccharides; Mice; Microglia; Molecular Structure; Nitric Oxide

2019
Simultaneous separation of six pure polymethoxyflavones from sweet orange peel extract by high performance counter current chromatography.
    Food chemistry, 2019, Sep-15, Volume: 292

    Topics: Chromatography, High Pressure Liquid; Citrus sinensis; Countercurrent Distribution; Flavones; Flavonoids; Humans; Plant Extracts; Spectrometry, Mass, Electrospray Ionization

2019
Characterization of polymethoxyflavone demethylation during drying processes of citrus peels.
    Food & function, 2019, Sep-01, Volume: 10, Issue:9

    Topics: Citrus; Demethylation; Desiccation; Flavones; Flavonoids; Food Handling; Fruit; Plant Extracts

2019
Quantitative analysis of multicomponents by single marker combined with HPLC fingerprint qualitative analyses for comprehensive evaluation of Aurantii Fructus.
    Journal of separation science, 2020, Volume: 43, Issue:7

    Topics: Chromatography, High Pressure Liquid; Citrus; Coumarins; Disaccharides; Flavanones; Flavones; Flavonoids; Fruit; Hesperidin

2020
Nobiletin, sinensetin, and tangeretin are the main perpetrators in clementines provoking food-drug interactions in vitro.
    Food chemistry, 2020, Jul-30, Volume: 319

    Topics: ATP Binding Cassette Transporter, Subfamily B; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Citrus; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Flavones; Flavonoids; Food-Drug Interactions; Fruit; Gene Expression Regulation; Humans; Peroxisome-Targeting Signal 1 Receptor; Receptors, Aryl Hydrocarbon

2020
An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar 'Ohta ponkan' (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity.
    Regulatory toxicology and pharmacology : RTP, 2020, Volume: 114

    Topics: Administration, Oral; Alzheimer Disease; Animals; Body Weight; Chromosome Aberrations; Citrus; Dose-Response Relationship, Drug; Female; Flavones; Functional Food; Male; Micronucleus Tests; Nootropic Agents; Parkinson Disease; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley

2020
Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation.
    International journal of biological macromolecules, 2020, Dec-01, Volume: 164

    Topics: Animals; Citrus; Flavones; Fruit; Kinetics; Lipase; Molecular Docking Simulation; Molecular Dynamics Simulation; Pancreas; Plant Extracts; Swine

2020