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nobiletin and 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone

nobiletin has been researched along with 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (46.15)29.6817
2010's7 (53.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miyazawa, M; Okuno, Y1
Dushenkov, S; Ho, CT; Lai, CS; Li, S; Lo, CY; Pan, MH1
Ho, CT; Lai, CS; Li, S; Lo, CY; Pan, MH; Sang, S; Yang, CS1
Kosano, H; Miyata, Y; Natsugari, H; Okuyama, Y; Oshitari, T; Takahashi, H2
Kosano, H; Miyata, Y; Natsugari, H; Okuyama, Y; Oshitari, T; Shimada, A; Takahashi, H1
Ferguson, S; Goodnow, R; Ho, CT; Jonca, M; Lambros, T; Li, S; Wang, Z1
Eguchi, A; Ho, CT; Li, S; Murakami, A; Ohigashi, H1
Al Rahim, M; Iwabuchi, Y; Maruyama, Y; Nakajima, A; Ohizumi, Y; Saigusa, D; Shibuya, M; Tetsu, N; Tomioka, Y; Yamakoshi, H; Yamakuni, T1
Gao, Z; Song, M; Wang, M; Wu, X; Xiao, H; Xu, F; Zhang, G; Zheng, J1
Gao, Z; Rakariyatham, K; Song, M; Wang, M; Wu, X; Xiao, H; Xu, F; Zheng, J1
Kawahata, I; Kusano, S; Mimaki, Y; Rico, EG; Suzuki, T; Tamura, H; Yamakuni, T1
Li, F; Qiu, P; Song, M; Wang, M; Wang, Q; Wu, X; Xiao, H; Xu, F; Zheng, J1

Other Studies

13 other study(ies) available for nobiletin and 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone

ArticleYear
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
    Journal of natural products, 2004, Volume: 67, Issue:11

    Topics: Aspergillus niger; Biotransformation; Citrus; Flavones; Flavonoids; Furylfuramide; Molecular Structure; Mutagenicity Tests; Plants, Medicinal; Salmonella typhimurium; SOS Response, Genetics

2004
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
    Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Chromatography, High Pressure Liquid; Citrus; Flavones; Fruit; HL-60 Cells; Humans; Hydroxylation; Indicators and Reagents; Magnetic Resonance Spectroscopy; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet

2007
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
    Bioorganic & medicinal chemistry letters, 2007, Sep-15, Volume: 17, Issue:18

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromatography, High Pressure Liquid; Flavones; Mice; Tandem Mass Spectrometry

2007
Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.
    Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15

    Topics: Acetophenones; Epithelial Cells; Flavones; Humans; Hydroxybenzoates; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors

2011
B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
    Bioorganic & medicinal chemistry, 2011, Dec-01, Volume: 19, Issue:23

    Topics: Cell Line; Enzyme Precursors; Epithelial Cells; Flavones; Humans; Lens, Crystalline; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Protease Inhibitors; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2011
Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.
    Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1

    Topics: Cataract; Cell Line; Cell Movement; Cell Proliferation; Citrus; Epithelial Cells; Flavones; Humans; Lens, Crystalline; Matrix Metalloproteinase 9; Structure-Activity Relationship

2013
Comparison of supercritical fluid chromatography and liquid chromatography for the separation of urinary metabolites of nobiletin with chiral and non-chiral stationary phases.
    Biomedical chromatography : BMC, 2006, Volume: 20, Issue:11

    Topics: Animals; Chromatography, Liquid; Chromatography, Supercritical Fluid; Female; Flavones; Mice; Stereoisomerism

2006
Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
    BioFactors (Oxford, England), 2007, Volume: 31, Issue:2

    Topics: CD36 Antigens; Cell Line; Down-Regulation; Flavones; Gene Expression; Humans; Monocytes; NF-kappa B; Receptors, Scavenger; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

2007
4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
    Biochemistry, 2009, Aug-18, Volume: 48, Issue:32

    Topics: Animals; Behavior, Animal; Cells, Cultured; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Fear; Flavones; Hippocampus; Learning; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Memory Disorders; Mice; Molecular Structure; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2009
Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis.
    Molecular nutrition & food research, 2015, Volume: 59, Issue:12

    Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Colitis; Colonic Neoplasms; Cytokines; Flavones; Humans; Male; Mice, Inbred Strains; Neoplasms, Experimental

2015
Inhibitory Effects of 4'-Demethylnobiletin, a Metabolite of Nobiletin, on 12-O-Tetradecanoylphorbol-13-acetate (TPA)-Induced Inflammation in Mouse Ears.
    Journal of agricultural and food chemistry, 2015, Dec-30, Volume: 63, Issue:51

    Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cytokines; Dermatitis; Dermatitis, Contact; Ear; Edema; Flavones; Male; Matrix Metalloproteinase 9; Mice; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphorylation; Phytotherapy; Skin; Tetradecanoylphorbol Acetate

2015
Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment.
    Journal of natural medicines, 2017, Volume: 71, Issue:4

    Topics: Animals; Aspergillus; Brain; Cell Culture Techniques; Choline O-Acetyltransferase; Citrus; Cyclic AMP Response Element-Binding Protein; Dementia; Dizocilpine Maleate; Fermentation; Flavones; Fruit; Hippocampus; Memory Disorders; Mice; Neurons; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Transcription, Genetic

2017
A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis.
    Food & function, 2018, Jan-24, Volume: 9, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Atorvastatin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Flavones; G1 Phase Cell Cycle Checkpoints; HT29 Cells; Humans; Molecular Structure; Rats; Rats, Inbred F344

2018