Compounds > nnc 711
Page last updated: 2024-09-03

nnc 711 and n-(4,4-diphenyl-3-butenyl)nipecotic acid

nnc 711 has been researched along with n-(4,4-diphenyl-3-butenyl)nipecotic acid in 7 studies

Compound Research Comparison

Studies
(nnc 711)		Trials
(nnc 711)		Recent Studies (post-2010)
(nnc 711)		Studies
(n-(4,4-diphenyl-3-butenyl)nipecotic acid)		Trials
(n-(4,4-diphenyl-3-butenyl)nipecotic acid)		Recent Studies (post-2010) (n-(4,4-diphenyl-3-butenyl)nipecotic acid)
112021121022

Protein Interaction Comparison

ProteinTaxonomynnc 711 (IC50)n-(4,4-diphenyl-3-butenyl)nipecotic acid (IC50)
Cytochrome P450 3A4Homo sapiens (human)0.6918
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)0.165
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)0.4099

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Borden, LA; Branchek, TA; Gluchowski, C; Murali Dhar, TG; Smith, KE; Weinshank, RL1
Nicklas, WJ; Zeevalk, GD1
Gaspary, HL; Richerson, GB; Wang, W1
Bernard, LP; Nicklas, WJ; Stokes, AH; Zeevalk, GD1
Ben-Ari, Y; Chiron, C; Gozlan, H; Quilichini, PP1
Hazehara, Y; Kitayama, S; Kunitomo, M; Morita, Y; Ohyama, K; Sogawa, C; Sogawa, N; Yoo, B1
Allen, CN; Cravetchi, O; Moldavan, M1

Other Studies

7 other study(ies) available for nnc 711 and n-(4,4-diphenyl-3-butenyl)nipecotic acid

ArticleYear
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
    European journal of pharmacology, 1994, Oct-14, Volume: 269, Issue:2

    Topics: Animals; Anticonvulsants; Carrier Proteins; Cell Line; Cloning, Molecular; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Humans; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nicotinic Acids; Nipecotic Acids; Organic Anion Transporters; Oximes; Pyridines; Rats; Recombinant Proteins; Structure-Activity Relationship; Tiagabine; Transfection

1994
Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina.
    Vision research, 1997, Volume: 37, Issue:24

    Topics: Animals; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Chick Embryo; Culture Techniques; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycolysis; Iodoacetates; Ischemia; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nipecotic Acids; Organic Anion Transporters; Oximes; Proline; Retina

1997
Carrier-mediated GABA release activates GABA receptors on hippocampal neurons.
    Journal of neurophysiology, 1998, Volume: 80, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Carrier Proteins; Cells, Cultured; Fetus; GABA Agents; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Neurons; Nipecotic Acids; Organic Anion Transporters; Oximes; Patch-Clamp Techniques; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium; Tetrodotoxin

1998
Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.
    Journal of neuroscience research, 2001, Apr-01, Volume: 64, Issue:1

    Topics: Animals; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Malonates; Mesencephalon; Muscimol; Neurons; Nipecotic Acids; Oximes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2001
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
    Epilepsia, 2006, Volume: 47, Issue:4

    Topics: Animals; Animals, Newborn; Anticonvulsants; Chloride Channels; Dioxolanes; Disease Models, Animal; Drug Interactions; Epilepsy; Excitatory Postsynaptic Potentials; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Neural Inhibition; Nipecotic Acids; Oximes; Patch-Clamp Techniques; Pentobarbital; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission

2006
Age-dependent changes in the susceptibility to thiopental anesthesia in mice: analysis of the relationship to the functional expression of GABA transporter.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 103, Issue:2

    Topics: Aging; Anesthetics, Intravenous; Animals; Base Sequence; DNA Primers; GABA Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred ICR; Nipecotic Acids; Oximes; Polymerase Chain Reaction; RNA, Messenger; Thiopental; Tritium

2012
GABA transporters regulate tonic and synaptic GABA
    Journal of neurophysiology, 2017, 12-01, Volume: 118, Issue:6

    Topics: Animals; Anisoles; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Male; Neurons; Nipecotic Acids; Oximes; Period Circadian Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Suprachiasmatic Nucleus; Synaptic Potentials

2017