nitrophenols and glycidyl-1-naphthyl-ether

nitrophenols has been researched along with glycidyl-1-naphthyl-ether* in 1 studies

Other Studies

1 other study(ies) available for nitrophenols and glycidyl-1-naphthyl-ether

Article	Year
Enantioselective detoxication of optical isomers of glycidyl ethers. Chirality, 1993, Volume: 5, Issue:7 The detoxication of the enantiomers of glycidyl 4-nitrophenyl ether (GNPE), (-)-(R)- and (+)-(S)-GNPE, and glycidyl 1-naphthyl ether (GNE), (-)-(R)- and (+)-(S)-GNE, by rat liver glutathione transferase and epoxide hydrolase was studied. Enantioselectivity was observed with both enzymes favoring the (R)-isomers as determined by the formation of conjugate, diol, and remaining substrate measured by HPLC. Enantiomers of GNE were detoxified by cytosolic epoxide hydrolase but those of GNPE were not. Substantial nonenzymatically formed conjugates of enantiomers of GNPE were detected showing (S)-GNPE the more reactive of the pair. Topics: Animals; Epoxide Hydrolases; Epoxy Compounds; Glutathione Transferase; Inactivation, Metabolic; Liver; Magnetic Resonance Spectroscopy; Male; Naphthols; Nitrophenols; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship	1993

Article

Year

Enantioselective detoxication of optical isomers of glycidyl ethers.

Chirality, 1993, Volume: 5, Issue:7

The detoxication of the enantiomers of glycidyl 4-nitrophenyl ether (GNPE), (-)-(R)- and (+)-(S)-GNPE, and glycidyl 1-naphthyl ether (GNE), (-)-(R)- and (+)-(S)-GNE, by rat liver glutathione transferase and epoxide hydrolase was studied. Enantioselectivity was observed with both enzymes favoring the (R)-isomers as determined by the formation of conjugate, diol, and remaining substrate measured by HPLC. Enantiomers of GNE were detoxified by cytosolic epoxide hydrolase but those of GNPE were not. Substantial nonenzymatically formed conjugates of enantiomers of GNPE were detected showing (S)-GNPE the more reactive of the pair.

Topics: Animals; Epoxide Hydrolases; Epoxy Compounds; Glutathione Transferase; Inactivation, Metabolic; Liver; Magnetic Resonance Spectroscopy; Male; Naphthols; Nitrophenols; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

1993