nitrophenols and bromophenophos

It was established that the antihelminth preparations dovenix and acedist are deposited in all inner organs and muscle tissues of laboratory animals (guinea-pigs) treated once with doses 0.1 cm by injection and 100 mg per os. Residual quantities of the named antihelminth preparations were found on the 6th to 57th day post treatment in the liver, lung, heart, kidneys, spleen and muscles. On the 61st day no residual quantities of the preparations were assessed in the muscles and inner organs. The hematological investigations and proteinogramms of experimental animals treated with dovenix and acedist do not reveal significant changes. In guinea-pigs treated with acedist a certain reduction of the beta- and gamma-globulin fractions is observed, while in those treated with dovenix the beta-globulin fractions are reduced.

Topics: Animals; Anthelmintics; Biphenyl Compounds; Blood; Blood Proteins; Drug Combinations; Guinea Pigs; Nitrophenols; Organophosphorus Compounds; Polybrominated Biphenyls; Sorbitol; Time Factors; Tissue Distribution

The excretion of residual amounts of acedist and dovenix with the milk of sheep that had been treated with these preparations was established on the 24th, resp., up to the 27th day following treatment, though their presence in the milk was found to drop sharply after the third day. The treatment with acedist led to a dependable decrease (P less than 0.05) in the hemoglobin amount, the total protein, and the erythrocyte count, and a dependable increase (P less than 0.05) in the leukocyte count. The intensity of these changes subsided parallel to the decrease in the residual amounts of the preparation in the milk excreted. The treatment with dovenix did not result in any deviations of the indices refered to.

Topics: Animals; Anthelmintics; Biphenyl Compounds; Blood; Blood Cell Count; Blood Proteins; Hemoglobins; Milk; Nitrophenols; Nitroxinil; Organophosphorus Compounds; Polybrominated Biphenyls; Sheep; Time Factors