nitrophenols and 3-cresol

nitrophenols has been researched along with 3-cresol* in 2 studies

Other Studies

2 other study(ies) available for nitrophenols and 3-cresol

Article	Year
Novel crystalline phase and first-order phase transitions of human insulin complexed with two distinct phenol derivatives. Acta crystallographica. Section D, Biological crystallography, 2015, Volume: 71, Issue:Pt 4 The primary focus of the present work is the study of the effects that two ligands and the crystallization pH have on the crystalline forms of human insulin. For this purpose, human insulin (HI) was co-crystallized with two distinct phenolic derivatives: the organic ligands meta-cresol (m-cresol) and 4-nitrophenol. The formation of polycrystalline precipitates was then followed by means of structural characterization of the individual specimens in terms of unit-cell symmetry and parameters. In both cases, two different polymorphs were identified via X-ray powder diffraction measurements, the first of hexagonal symmetry (R3 space group) at higher pH values and the second of monoclinic symmetry (space group P21) with unit-cell parameters a = 87.4282 (5), b = 70.5020 (3), c = 48.3180 (4) Å, β = 106.8958 (4)°, the latter of which to our knowledge has never been observed before. Topics: Cresols; Crystallization; Crystallography, X-Ray; Humans; Insulins; Models, Molecular; Nitrophenols; Phase Transition; Powder Diffraction; X-Ray Diffraction	2015
Two automated procedures for N-acetyl-beta-D-glucosaminidase determination evaluated for detection of drug-induced tubular nephrotoxicity. Clinical chemistry, 1986, Volume: 32, Issue:11 We automated two procedures for determination of urinary N-acetyl-beta-D-glucosaminidase (NAG; EC 3.2.1.30) concentrations and evaluated their reliability for detecting drug-induced tubular damage in children receiving cisplatin, methotrexate, or ifosfamide. Results for 174 patient specimens correlated well (r = 0.98), but NAG concentrations determined by the m-cresolsulfonphthaleinyl (MCP) procedure were about 40% lower than those obtained with p-nitrophenyl-N-acetyl-beta-D-glucosaminide substrate. Dialysis and assay of 50 specimens disclosed no evidence of activators or inhibitors of enzymatic activity. Drugs and metabolites added to urine had negligible effect on NAG determinations; however, NAG was unstable in alkaline urine (pH greater than 8) associated with methotrexate therapy. Both procedures detect tubular damage equally well and neither requires laborious sample treatment. The MCP procedure, being more sensitive and not requiring a sample blank, is better suited for rapid automated assays. Comparisons of clinical data obtained by the two procedures require standardization against human NAG. Topics: Acetylglucosaminidase; Adolescent; Antineoplastic Agents; Autoanalysis; Child; Child, Preschool; Cresols; Dialysis; Hexosaminidases; Humans; Kidney Diseases; Kidney Tubules; Nitrophenols; Spectrophotometry	1986

Article

Year

Novel crystalline phase and first-order phase transitions of human insulin complexed with two distinct phenol derivatives.

Acta crystallographica. Section D, Biological crystallography, 2015, Volume: 71, Issue:Pt 4

The primary focus of the present work is the study of the effects that two ligands and the crystallization pH have on the crystalline forms of human insulin. For this purpose, human insulin (HI) was co-crystallized with two distinct phenolic derivatives: the organic ligands meta-cresol (m-cresol) and 4-nitrophenol. The formation of polycrystalline precipitates was then followed by means of structural characterization of the individual specimens in terms of unit-cell symmetry and parameters. In both cases, two different polymorphs were identified via X-ray powder diffraction measurements, the first of hexagonal symmetry (R3 space group) at higher pH values and the second of monoclinic symmetry (space group P21) with unit-cell parameters a = 87.4282 (5), b = 70.5020 (3), c = 48.3180 (4) Å, β = 106.8958 (4)°, the latter of which to our knowledge has never been observed before.

Topics: Cresols; Crystallization; Crystallography, X-Ray; Humans; Insulins; Models, Molecular; Nitrophenols; Phase Transition; Powder Diffraction; X-Ray Diffraction

2015

Two automated procedures for N-acetyl-beta-D-glucosaminidase determination evaluated for detection of drug-induced tubular nephrotoxicity.

Clinical chemistry, 1986, Volume: 32, Issue:11

We automated two procedures for determination of urinary N-acetyl-beta-D-glucosaminidase (NAG; EC 3.2.1.30) concentrations and evaluated their reliability for detecting drug-induced tubular damage in children receiving cisplatin, methotrexate, or ifosfamide. Results for 174 patient specimens correlated well (r = 0.98), but NAG concentrations determined by the m-cresolsulfonphthaleinyl (MCP) procedure were about 40% lower than those obtained with p-nitrophenyl-N-acetyl-beta-D-glucosaminide substrate. Dialysis and assay of 50 specimens disclosed no evidence of activators or inhibitors of enzymatic activity. Drugs and metabolites added to urine had negligible effect on NAG determinations; however, NAG was unstable in alkaline urine (pH greater than 8) associated with methotrexate therapy. Both procedures detect tubular damage equally well and neither requires laborious sample treatment. The MCP procedure, being more sensitive and not requiring a sample blank, is better suited for rapid automated assays. Comparisons of clinical data obtained by the two procedures require standardization against human NAG.

Topics: Acetylglucosaminidase; Adolescent; Antineoplastic Agents; Autoanalysis; Child; Child, Preschool; Cresols; Dialysis; Hexosaminidases; Humans; Kidney Diseases; Kidney Tubules; Nitrophenols; Spectrophotometry

1986