nitroglycerin has been researched along with cyclic gmp in 373 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (20.91) | 18.7374 |
| 1990's | 177 (47.45) | 18.2507 |
| 2000's | 95 (25.47) | 29.6817 |
| 2010's | 22 (5.90) | 24.3611 |
| 2020's | 1 (0.27) | 2.80 |
| Authors | Studies |
|---|---|
| Berkowitz, BA; Cohen, ML | 2 |
| Arnold, WP; Katsuki, S; Murad, F | 1 |
| Andersson, RG; Axelsson, KL; Wikberg, JE | 3 |
| Kobayashi, A; Ogawa, K | 1 |
| Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Akita, H; Hirata, K; Watanabe, Y; Yokoyama, M | 1 |
| Anggard, E; Mollace, V; Pistelli, A; Salvemini, D; Vane, J | 3 |
| Aronson, WJ; Buga, GM; Bush, PA; Ignarro, LJ; Rajfer, J | 1 |
| Akimoto, Y; Jino, H; Kurahashi, K; Usui, H | 1 |
| Fujiwara, N; Fukuda, S; Sakuma, K; Shimoji, K; Tanaka, T; Tsukui, A | 1 |
| Chen, XL; McDaniel, NL; Murphy, RA; Rembold, CM; Singer, HA | 1 |
| Duboc, D; Guérin, F; Weber, S | 1 |
| Gryglewski, RJ; Salvemini, D; Taylor, GW; Vane, JR; Zembowicz, A | 1 |
| Fukushima, H; Jinno, Y; Kasai, H; Nishikori, K; Ogawa, N; Ohta, H | 1 |
| Hoffman, BB; Honda, K; Hu, ZW; Murad, F | 1 |
| Schröder, H | 1 |
| Bennett, BM; Long, PG; McDonald, BJ; Nigam, R; Simon, WC | 1 |
| Allen, SP; Chester, AH; Luu, TN; O'Neil, GS; Schyns, CJ; Tadjkarimi, S; Yacoub, MH | 1 |
| Longo, LD; Pearce, WJ | 1 |
| Burke-Wolin, T; Cherry, PD; Mortelliti, MP; Omar, HA; Wolin, MS | 1 |
| Okamura, T; Toda, N | 1 |
| Feelisch, M; Kelm, M | 1 |
| Ahlner, J; Axelsson, KL; Bertler, A; Norlander, B; Torfgård, K | 2 |
| Komori, S; Ohashi, H; Sugisawa, K; Takewaki, T | 1 |
| Cantor, E; Greenberg, SS; Ho, E; Walega, M | 1 |
| Torphy, TJ; Zhou, HL | 1 |
| Förstermann, U; Frölich, JC; Kuhn, M; Otten, A | 1 |
| Brien, JF; Kawamoto, JH; Marks, GS; McLaughlin, BE; Nakatsu, K | 1 |
| Ney, P; Schröder, H; Schrör, K; Woditsch, I | 1 |
| Lawson, DL; Mehta, JL; Mehta, P; Nichols, WW | 1 |
| Hester, RK; Koibuchi, Y; Matsuo, M; Satake, N; Sato, N; Shibata, S | 1 |
| Förster, S; Schröder, H; Schrör, K; Woditsch, I | 2 |
| Cipkus-Dubray, LA; Hosner, JM; Khan, SA; Meisheri, KD | 1 |
| Allen, SP; Chester, AH; Khagani, A; Luu, TN; Musumeci, F; O'Neil, GS; Ridley, P; Tadjkarimi, S; Yacoub, MH | 1 |
| Anggard, E; Mollace, V; Salvemini, D; Vane, J | 1 |
| Laustiola, KE; Manninen, V; Metsä-Ketelä, T; Pörsti, I; Vapaatalo, H; Vuorinen, P | 1 |
| Fujino, K; Inoue, I; Miyoshi, Y; Mori, H; Nakaya, S; Nakaya, Y; Wakatsuki, T | 1 |
| Lawson, DL; Mehta, JL; Nichols, WW | 1 |
| Moncada, S; Palmer, RM; Rees, DD; Schulz, R | 1 |
| Ney, P; Schröder, H; Schrör, K | 1 |
| Kato, R; Nakaki, T; Nakayama, M | 1 |
| Schröder, H; Schrör, K | 1 |
| Chu, A; Cobb, FR; Hagen, PO; Lin, CC; Murray, JJ; Russell, M | 1 |
| Ando, S; Hirooka, Y; Imaizumi, T; Nakamura, M; Suzuki, S; Takeshita, A; Yoshida, M | 1 |
| Ahlner, J; Andersson, RG; Axelsson, KL; Karczewski, P | 1 |
| Brinker, MR; Cook, SD; Hyman, AL; Lippton, HL | 1 |
| Aubineau, P; Ignarro, L; Lee, J; Pearce, WJ; Reynier-Rebuffel, AM; Seylaz, J | 1 |
| Cherry, PD; Farrell, KA; Omar, HA; Stuart, JS; Wolin, MS | 1 |
| Fyhrquist, F; Ristimäki, A; Saijonmaa, O | 1 |
| McWilliam, TM; Rankin, AJ; Swift, FV; Triggle, CR | 1 |
| Furchgott, RF; Jothianandan, D; Martin, W; Villani, GM | 3 |
| Bossaller, C; Habib, GB; Henry, PD; Wells, S; Williams, C; Yamamoto, H | 1 |
| Ignarro, LJ; Wood, KS | 1 |
| Ginsburg, R; Molina, CR; Murad, F; Rapoport, RM; Waldman, SA | 1 |
| Andresen, JW; Molina, CR; Murad, F; Rapoport, RM; Waldman, S | 1 |
| Karaki, H; Murakami, K; Urakawa, N | 1 |
| Holzmann, S; Kukovetz, WR | 6 |
| Domae, M; Hashimoto, T; Kitamura, K; Kuriyama, H; Nakao, K; Sumimoto, K; Yamanaka, K | 1 |
| Hyman, AL; Kadowitz, PJ; Lippton, HL | 1 |
| Adamik, R; Manganiello, VC; Moss, J; Tsai, SC | 1 |
| Bennett, BM; Kawamoto, JH; Leitman, DC; Murad, F; Nakatsu, K; Schröder, H | 1 |
| Fujimoto, K; Kanamaru, K; Kojima, T; Waga, S | 1 |
| Ahlner, J; Axelsson, KL; Torfgård, K | 1 |
| Brien, JF; Kawamoto, J; Marks, GS; McLaughlin, B; Nakatsu, K; Slack, C | 1 |
| Hawlicek, J; Kalenbach, M; Kirsten, N; Kober, G; Krause, A; Satter, P; Schneider, W; von Loh, D; Weyenmeyer, T | 1 |
| Kai, H; Kanaide, H; Nakamura, M | 1 |
| Antoni, FA; Dayanithi, G | 1 |
| Bassenge, E; Busse, R; Mülsch, A; Winter, I | 1 |
| Bassenge, E; Busse, R; Mülsch, A | 2 |
| Eskinder, H; Gross, GJ | 2 |
| Brien, JF; Kawamoto, JH; Kobus, SM; Marks, GS; McLaughlin, BE; Nakatsu, K | 1 |
| Chapnick, BM; Ohlstein, EH; Secrest, RJ | 1 |
| Ahlner, J; Andersson, RG; Axelsson, KL; Ekstram-Ljusegren, M; Friedman, RL; Grundström, N; Karlsson, JO | 1 |
| Buga, GM; Byrns, RE; Chaudhuri, G; Ignarro, LJ; Wood, KS | 1 |
| Ahlner, J; Axelsson, KL; Ljusegren, ME | 1 |
| Ahlner, J; Andersson, RG; Axelsson, KL; Karlsson, JG | 1 |
| Hashimoto, H; Ito, T; Nakagawa, H; Ogawa, K; Okumura, K; Satake, T | 1 |
| Kukovetz, WR; Schmidt, K | 1 |
| Ahlner, J; Andersson, RG; Axelsson, KL; Bergdahl, B; Dahlström, U; Rydell, EL | 1 |
| Ahlner, J; Andersson, RG; Axelsson, KL; Dahlström, U; Rydell, EL | 1 |
| Holzmann, S; Kukovetz, WR; Romanin, C | 1 |
| Bennett, BM; Hayward, LD; Murad, F; Schröder, H; Waldman, SA | 1 |
| Johnson, RM; Lincoln, TM | 1 |
| Itoh, T; Kanmura, Y; Kuriyama, H; Sasaguri, T | 1 |
| Gruetter, CA; Lemke, SM | 2 |
| Flaherty, JT | 1 |
| Axelsson, KL; Karlsson, JO; Pettersson, G | 1 |
| Ahlner, J; Andersson, RG; Areskog, NH; Axelsson, KL | 1 |
| Hashimoto, H; Ito, T; Nakagawa, H; Ogawa, K; Satake, T; Shibata, T | 1 |
| Chuprun, JK; Rapoport, RM | 1 |
| Axelsson, KL; Bornfeldt, KE | 1 |
| Mentzer, RM; Walsh, RS | 1 |
| Kreye, VA | 1 |
| Osnes, JB | 1 |
| Gruetter, CA; Ignarro, LJ | 1 |
| Andersson, RG; Axelsson, KL | 1 |
| Laustiola, K; Metsä-Ketelä, T; Vapaatalo, H; Vuorinen, P | 1 |
| Axelsson, KL; Karlsson, JO | 1 |
| Hayashi, H; Kamikawa, T; Kobayashi, A; Suzuki, Y; Yamazaki, N | 1 |
| Braughler, JM | 1 |
| Gruetter, CA; Gruetter, DY; Ignarro, LJ; Kadowitz, PJ; Lyon, JE | 1 |
| Burkman, AM; Fertel, RH; Keith, RA; Sokoloski, TD | 2 |
| Diamond, J | 1 |
| Chu, EB; Diamond, J | 1 |
| Cingolani, H; Rinaldi, G | 1 |
| Edwards, JC; Hyman, AL; Ignarro, LJ; Kadowitz, PJ | 1 |
| Burke, TM; Ignarro, LJ; Kadowitz, PJ; Wolin, MS; Wood, KS | 1 |
| Cingolani, HE; de Hurtado, MC | 1 |
| Castresana, MR; Jollow, DJ; McDonald, MH; Newman, WH; Zhang, LM | 1 |
| Keen, M; Key, BJ; Matthews, JS; McWilliams, PJ | 1 |
| Bassenge, E; Zanzinger, J | 1 |
| Anfossi, G; Cavalot, F; Massucco, P; Mattiello, L; Mularoni, E; Trovati, M | 2 |
| Catravas, JD; Cheng, C; Marczin, N; Milici, A; Papapetropoulos, A; Snead, MD | 1 |
| Brett, J; Broekman, MJ; Cannon, PJ; Koga, S; Liao, H; Marcus, AJ; Naka, Y; Oz, MC; Pinsky, DJ; Taha, Z | 1 |
| Bredt, DS; Dinger, B; Fidone, SJ; Stensaas, LJ; Wang, ZZ | 1 |
| Fujihara, H; Fujiwara, N; Fukuda, S; Sakuma, K; Shimoji, K; Tanaka, T; Toriumi, T; Tsukui, A | 1 |
| Carayon, A; Cloarec-Blanchard, L; Funck-Brentano, C; Jaillon, P | 1 |
| Hamaguchi, M; Imai, S; Ishibashi, T; Kato, K; Kawada, T | 1 |
| D'Alecy, LG; Jin, JS; Webb, RC | 1 |
| Lassen, LH; Olesen, IJ; Olesen, J; Thomsen, LL | 1 |
| Arthur, AS; Kassell, NF; Lee, KS; Sutter, B; Suzuki, S | 1 |
| Forssmann, WG; Haverich, A; Heublein, B; Kuhn, M; Lichtlen, PR; Mügge, A; Nolte, C; Warnecke, J | 1 |
| Chirkov, YY; Horowitz, JD; Naujalis, JI; Sage, RE | 1 |
| Ahlner, J; Torfgård, KE | 1 |
| Fujioka, H; Kinoshita, M; Miyauchi, N; Takahashi, M | 1 |
| Kojda, G; Noack, E | 1 |
| Arakawa, M; Imai, S; Nakazawa, M; Sasage, H | 1 |
| Benet, LZ; Haj-Yehia, AI | 2 |
| Satake, N; Shibata, S; Zhou, Q | 1 |
| Garfield, RE; Izumi, H; Makino, Y; Shirakawa, K | 1 |
| Fukai, D; Hisanaga, T; Kinoshita, M; Maeda, K; Maeda, Y; Tsutamoto, T; Wada, A; Yoshida, S | 1 |
| Furuya, M; Hidaka, T; Ohno, T; Tani, Y | 1 |
| Abendschein, DR; Meng, YY; Ryan, US; Trachtenburg, J | 1 |
| Benet, LZ; Han, C; Kenkare, SR | 1 |
| Baines, CP; Ball, HA; Szwarc, RS | 1 |
| Bina, S; Hart, JL; Jing, M; Muldoon, SM | 1 |
| Carretero, OA; Harding, P; LaPointe, MC | 1 |
| Imai, S; Ishibashi, T; Kato, K; Kawada, T; Sasage, H | 1 |
| Furuichi, A; Isono, T; Kohsaka, M; Koibuchi, Y; Mori, J; Nishii, M; Ohtsuka, M; Sato, N; Yamamoto, T | 1 |
| Banerjee, A; Fullerton, DA; Hahn, AR; Harken, AH | 1 |
| Ando, J; Kamiya, A; Korenaga, R; Toyo-oka, T; Yang, W | 1 |
| Hull, AD; Long, DM; Pearce, WJ; White, CR | 1 |
| Bor, P; Ferdinandy, P; Jakab, I; Koltai, M; Lonovics, J; Nagy, I; Szilvassy, J; Szilvassy, Z | 1 |
| de Ridder, L; Lameire, N; Van de Voorde, J; Verbeke, M | 1 |
| Anderson, DJ; Bennett, BM; McGuire, JJ | 1 |
| Imai, S; Nakazawa, M | 1 |
| Leusen, I; Van de Voorde, J; Vanheel, B | 1 |
| Barbier, AJ; Lefebvre, RA | 1 |
| Adachi, T; Kinoshita, M; Maeda, Y; Ohbayashi, Y; Tsutamoto, T; Wada, A | 1 |
| Baribeau, J; Johnstone, MT; Lacoste, L; Lam, JY; Théroux, P; Waters, D | 1 |
| Bennett, BM; Nigam, R; Whiting, T | 1 |
| Abe, S; Kanaide, H; Nakamura, M; Nishimura, J | 1 |
| Arden, WA; Diana, JN; Fiscus, RR; Hao, H; Wang, X | 1 |
| Castresana, MR; Newman, WH; Zhang, LM | 1 |
| O'Connor, B; Pagani, ED; Silver, PJ; VanAller, GS | 1 |
| Pistelli, A; Salvemini, D; Vane, J | 1 |
| Amado, JA; Berrazueta, JR; Ochoteco, J; Poveda, JJ; Puebla, F; Salas, E; Sarabia, M | 1 |
| Aarhus, LL; Burnett, JC; Cavero, PG; Heublein, DM; Miller, WL | 1 |
| Fujimoto, K; Kawashima, K; Nonaka, H; Suzuki, T | 1 |
| Geppetti, P; Granger, H; Ledda, F; Masini, E; Morbidelli, L; Ziche, M | 1 |
| Enomoto, T; Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H; Yasui, K | 1 |
| Fung, HL | 1 |
| Hamaguchi, M; Imai, S; Ishibashi, T; Kato, K; Kawada, T; Ohta, H; Sasage, H | 1 |
| Benet, LZ; Kenkare, SR | 2 |
| Kinoshita, M; Matsumoto, T; Okamura, T; Toda, N | 1 |
| Bath, PM | 1 |
| Kinoshita, M; Matsumoto, T; Nakae, I; Takahashi, M | 1 |
| Edvinsson, L; Jansen-Olesen, I; You, J; Zhang, W | 1 |
| Brands, F; Feelisch, M; Kelm, M | 1 |
| Anfossi, G; Cavalot, F; Massucco, P; Mattiello, L; Mularoni, E; Piretto, V; Trovati, M | 1 |
| Kojda, G; Kottenberg, K; Nix, P; Noack, E; Piper, HM; Schlüter, KD | 1 |
| Brunner, F; Mayer, B; Nielsen, EB; Schmidt, K | 1 |
| Humphrey, SJ; Schwende, FJ | 1 |
| Bassenge, E; Fink, B | 1 |
| Hohn, J; Papp, JG; Pataricza, J; Penke, B; Toth, GK | 1 |
| Anfossi, G; Cavalot, F; Massucco, P; Mattiello, L; Mularoni, E; Paoletti, G; Piretto, V; Trovati, M | 1 |
| Cremonesi, P; Donà, G; Giuliani, P; Mizrahi, J; Passaro, A; Stella, P; Tursi, F | 1 |
| Kanamaru, K; Murata, H; Nakao, K; Waga, S | 1 |
| Bell, DR; Dec, EM; Rensberger, HJ | 1 |
| Haught, WH; Lawson, DL; Mehta, JL; Mehta, P | 1 |
| Bauer, JA; Booth, BP; Fung, HL; Jacob, S | 1 |
| Bhabra, MS; Hooper, TL; Hopkinson, DN; Shaw, TE | 1 |
| Bode, DC; Buchholz, RA; De Garavilla, L; Dundore, R; Jackson, KN; Pagani, ED; Pratt, P; Silver, PJ; Volberg, ML | 1 |
| Bina, S; Jing, M; Ledvina, MA; Muldoon, SM; Panico, FG; Panico, JL | 1 |
| Anderson, DJ; Bennett, BM; Simon, WC | 1 |
| Lipton, SA; Pan, ZH; Segal, MM | 1 |
| Castresana, MR; Newman, WH; Shillcutt, SD; Tao, H; Zhang, LM | 1 |
| Drewett, JG; Herzig, TC; Knych, ET; Olson, LJ | 1 |
| Hébert, D; Lam, JY; Xiang, JX | 1 |
| McDaniel, NL; Rembold, CM; van Riper, DA | 1 |
| Hirashima, O; Kawano, H; Kugiyama, K; Motoyama, T; Ohgushi, M; Sugiyama, S; Yasue, H | 1 |
| Chen, LY; Mehta, JL | 1 |
| Ferdinandy, P; Jakab, I; Koltai, M; Nagy, I; Szilvassy, Z | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Kubo, T; Taguchi, K; Ueda, M | 1 |
| Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H | 8 |
| Diamond, J; Patel, AI | 1 |
| Aoki, H; Harada, M; Imai, H; Inoue, M; Kobayashi, A; Mizobe, T | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Mitsunami, K; Nakae, I; Takahashi, M; Takaoka, A | 1 |
| Hacker, A; Kojda, G; Noack, E; Patzner, M | 1 |
| Hintze, TH; Ochoa, M; Stewart, JM; Xu, X | 1 |
| Imai, S; Ishibashi, T; Kitagawa, T | 1 |
| Cosentino, F; Ganten, D; Mele, AF; Muscolo, M; Natale, A; Rubattu, S; Russo, R; Savoia, C; Vecchione, C; Volpe, M | 1 |
| Anfossi, G; Burzacca, S; Cavalot, F; Massucco, P; Mattiello, L; Mularoni, EM; Ponziani, MC; Trovati, M | 1 |
| Bina, S; Hart, JL; Jing, M; Ling, GS; Muldoon, SM | 1 |
| Hinz, B; Schröder, H | 3 |
| Bassenge, E; Fink, B; Fink, N; Skatchkov, M | 1 |
| Bacon, ER; Bode, DC; de Garavilla, L; Dundore, RL; Pagani, ED; Silver, PJ | 1 |
| Ikezaki, H; Onyüksel, H; Rubinstein, I | 1 |
| Bassenge, E; Dikalov, S; Fink, B; Skatchkov, M; Stalleicken, D | 1 |
| Jakab, I; Lonovics, J; Nagy, I; Sári, R; Szilvássy, Z | 1 |
| Giugliano, D; Marfella, R | 1 |
| Csont, T; Ferdinandy, P; Páli, T; Szilvássy, Z | 1 |
| Liu, P; Niu, WZ; Shen, J | 1 |
| Hansson, GK; Jörnvall, H; Lindahl, SG | 1 |
| De la Lande, IS; Horowitz, JD; Stafford, I | 1 |
| Barba, G; Donald, A; MacAllister, RJ; Mullen, MJ | 1 |
| Goto, Y; Hasegawa, K; Muramatsu, I; Takakura, K; Taniguchi, T | 1 |
| Andrews, NP; Husain, M; Padder, FA; Prasad, A; Quyyumi, AA | 1 |
| Inoue, S; Kawata, S; Kayanoki, Y; Kiso, S; Matsuzawa, Y; Tamura, S; Taniguchi, N; Yamasaki, E | 1 |
| Omote, M | 1 |
| Bassenge, E; Fink, B; Fink, N; Schwemmer, M | 1 |
| Asbun, J; Castillo, C; Castillo, EF; Escalante, B; López, P; Villalón, CM | 1 |
| Bando, T; Hitomi, S; Isowa, N; Kawashima, M; Liu, M; Nakamura, T; Toyokuni, S; Wada, H | 1 |
| Nakaki, T | 1 |
| Kelley, T; Larson, D; Sanders, DB | 1 |
| Eyk, JE; Foster, DB; Rembold, CM; Strauss, JD; Wingard, CJ | 1 |
| Blaise, G; Costachescu, T; Derouin, M; Jiang, ZY | 1 |
| Grosser, N; Schröder, H | 1 |
| Duarte, ID; Leite, R; Soares, AC; Tatsuo, MA | 1 |
| Batignani, G; Caligiuri, A; DeFRANCO, RM; Failli, P; Gentilini, A; Gentilini, P; Guerra, CT; Laffi, G; Marra, F; Pinzani, M; Romanelli, RG | 1 |
| Chang, W; Hsiao, G; Lee, C; Lee, LW; Lin, CH; Sheu, JR; Su, CH | 1 |
| Martin, DD; Parker, JD; Tong, JS | 1 |
| Adams, MA; Bennett, BM; Fraser, AB; Ratz, JD; Rees-Milton, KJ | 1 |
| Caidahl, K; Petersson, AS; Ringqvist, A; Wennmalm, A | 1 |
| Magid, KS; Megson, IL; Shaw, CA; Sogo, N; Webb, DJ | 1 |
| Kurata, N; Mizumura, J; Nakamura, S; Nishimura, Y; Sumi, M; Yamamoto, T; Yasuhara, H | 1 |
| Hobbs, AJ; Hussain, MB; MacAllister, RJ | 1 |
| Donahue, JK; Lawrence, JH; Marbán, E; Nagata, K | 1 |
| Brien, JF; Marks, GS; McLaughlin, BE; Nakatsu, K; O'Reilly, DA | 1 |
| Anggård, EE; Assaf, P; Haj-Yehia, AI; Nassar, H; Nassar, T | 1 |
| Kinoshita, M; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M | 1 |
| Schäfer, WR; Stehmans, A; Wetzka, B; Zahradnik, HP | 1 |
| Caponas, G | 1 |
| Kakiailatu, FA | 1 |
| Hink, U; Klöss, S; Meinertz, T; Mollnau, H; Mülsch, A; Münzel, T; Oelze, M; Smolenski, A; Stasch, JP; Töpfer, A; Walter, U; Warnholtz, A | 1 |
| Clarkson, M; Murphy, RA; O'Connor, M; Rembold, CM; Wardle, RL | 1 |
| Fung, HL; Soda, DM; Wang, EQ | 1 |
| Kagota, S; Kunitomo, M; Kuno, T; Nakamura, K; Sugiura, R; Tamashiro, A; Yamaguchi, Y | 1 |
| Beavo, JA; Berk, BC; Kim, D; Munzel, T; Pi, X; Rybalkin, SD; Wang, Y; Yan, C; Zhang, C | 1 |
| Haramaki, N; Haramaki, R; Ikeda, H; Imaizumi, T; Kanaya, S; Katoh, A; Murohara, T; Shintani, S; Takajo, Y | 1 |
| Hirose, R; Ichimura, M; Irie, J; Nomoto, Y; Ohno, T; Okumura, H; Onoda, Y; Takai, H; Yoshimatsu, A | 1 |
| Fung, HL; Lee, WI; Wang, EQ | 1 |
| Meinertz, T; Münzel, T; Oelze, M; Reichenspurner, H; Reiter, B; Rinze, R; Schulz, E; Tsilimingas, N; Walter, U; Wendt, M; Woelken-Weckmüller, S | 1 |
| Iannone, M; Mollace, V; Muscoli, C; Nisticò, R; Palma, E; Romeo, F; Rotiroti, D; Salvemini, D | 1 |
| Andersson, E; Fried, G; Sand, AE | 1 |
| Tsuchida, K; Watajima, H | 1 |
| Endo, H; Hayashi, T; Iguchi, A; Kano, H; Matusi-Hirai, H; Sumi, D; Tsunekawa, T | 1 |
| Kim, HS; Lee, J; Moon, JD; Yoo, KY | 1 |
| Devine, AB; Dixon, LJ; Hamilton, P; Hanratty, CG; Leahey, WJ; McGrath, LT; McVeigh, GE; Morgan, DG; Wilson, M | 1 |
| Bennett, BM; Boegman, RJ; Dumitrascu, A; Jhamandas, K; Ratz, JD; Reynolds, JN; Scutaru, D; Thatcher, GR; Zavorin, SI | 1 |
| Aniya, Y; Kukita, I; Matsuzaki, T; Miyagi, K; Nakasone, J; Noguchi, K; Sakanashi, M | 1 |
| Bertel, O; Brunner-La Rocca, HP; Kiowski, W; Oechslin, E; Schad, K; Schalcher, C; Scharf, C; Schindler, R; Suetsch, G | 1 |
| Fujimoto, S; Mori, M; Tsushima, H | 1 |
| Hull, AD; Nauli, SM; Pearce, WJ; White, CR | 1 |
| Anfossi, G; Massucco, P; Mattiello, L; Russo, I; Trovati, M | 1 |
| Hobbs, AJ; MacAllister, RJ; Madhani, M; Scotland, RS | 1 |
| Anfinogenova, IaD; Baskakov, MB; Borodin, IuL; Kapilevich, LV; Kovalev, IV; Medvedev, MA; Minochenko, IL; Popov, AA | 1 |
| Abou-Mohamed, G; Caldwell, RB; Caldwell, RW; Do, K; El-Remessy, AB; Jin, L; Johnson, JA; Kaesemeyer, WH | 1 |
| Amado, JA; Bustamante, M; de Berrazueta, JR; Garcia-Unzueta, MT; Llorca, J; Sampedro, I | 1 |
| Itoh, T; Kajikuri, J; Kanmura, Y; Kusama, N; Nakano, Y; Suzuki, Y | 1 |
| Deng, HW; Du, YH; Huang, ZZ; Jiang, DJ; Li, YJ; Peng, J | 1 |
| August, M; Chen, Z; Daiber, A; Keaney, JF; Mülsch, A; Münzel, T; Oelze, M; Schulz, E; Stamler, JS; Sydow, K; Ullrich, V; Wendt, M | 1 |
| Berndt, G; Grosser, N; Hoogstraate, J; Schröder, H | 1 |
| Cittadino, M; Moreno, H; Sabha, M; Sousa, MG; Tácito, LH; Tanus-Santos, JE; Yugar-Toledo, JC | 1 |
| Blandini, F; Greco, R; Nappi, G; Tassorelli, C | 1 |
| Hegyi, P; Kovacs, P; Lonovics, J; Nagy, I; Nemeth, J; Palvolgyi, A; Peitl, B; Porszasz, R; Sari, R; Szilvassy, Z | 1 |
| Hellstrand, P; Lehen'kyi, V; Soloviev, A; Zelensky, S | 1 |
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| Chen, Z; Cobb, FR; Stamler, JS; Zhang, J | 1 |
| Brunner, F; Hofer, A; Keung, WM; Koesling, D; Kollau, A; Mayer, B; Russwurm, M; Schmidt, K | 1 |
| Bennett, BM; Nicolescu, AC; Thatcher, GR; Toader, V | 1 |
| Kloner, RA | 1 |
| Chan, DC; Dogra, GK; Stanton, K; Watts, GF | 1 |
| Diallo, AS; Lobysheva, I; Muller, B; Sarr, M; Schini-Kerth, VB; Stoclet, JC | 1 |
| Aulaskari, P; Haukka, M; Kotikoski, H; Moilanen, E; Oksala, O; Oresmaa, L; Pohjala, E; Salminen, J; Vainiotalo, P; Vapaatalo, H | 1 |
| Berkenboom, G; Fontaine, D; Fontaine, J; Otto, A | 1 |
| Chen, Z; Foster, MW; Hess, DT; Kawamoto, T; Kitagawa, K; Mao, L; Nakayama, KI; Rockman, HA; Stamler, JS; Zhang, J | 1 |
| Bode-Böger, SM; Kojda, G | 1 |
| Antunes, E; Baracat, JS; Claudino, MA; De Nucci, G; Priviero, FB; Teixeira, CE; Webb, RC | 1 |
| Egan, TM; Hoffmann, SC; Sadoff, JD; Schlidt, SA; Sevala, M | 1 |
| Ahlner, J; Andersson, RG; Persson, K; Säfholm, AC | 1 |
| Hai, S; Minamiyama, Y; Okada, S; Suehiro, S; Takemura, S | 1 |
| Berkenboom, G; Fontaine, J; Otto, A | 1 |
| Bosca, I; D'Ocon, P; Esplugues, JV; Herance, JR; Ibiza, S; Nuñez, C; Ortega, A; Rocha, M; Serrador, JM; Victor, VM | 1 |
| Dukhanin, AS; Shimanovskii, NL | 1 |
| Coelho, OR; Consolim-Colombo, FM; Ferreira-Melo, SE; Irigoyen, MC; Moreno, H; Yugar-Toledo, JC | 1 |
| Boor, PJ; Chu, ET; Dwivedi, S; Fitchett, K; Li, J; Wang, L; Xu, Y; Yang, Y | 1 |
| Braz, JC; Etgen, GJ; Gill, RM; Jin, N; Shen, W | 1 |
| Dou, D; Gao, Y; Qi, H; Qin, X; Raj, JU; Zheng, X | 1 |
| Adams, MA; Bennett, BM; Frederiksen, LJ; Graham, CH; Macdonald-Goodfellow, SK; Maxwell, LR; Siemens, DR; Sullivan, R | 1 |
| Coldewey, M; Daiber, A; Förstermann, U; Hink, U; Hortmann, M; Lehmann, J; Li, H; Mollnau, H; Münzel, T; Oelze, M; Seeling, A; Stalleicken, D; Weiner, H; Wenzel, P | 1 |
| Chen, YR; Guo, R; Jiang, DJ; Li, YJ; Nie, SD; Shan, W; Shi, RZ; Zhang, Z; Zhou, Z | 1 |
| Kaneko, K; Tsuchida, K | 1 |
| Aburawi, EH; Andersson, S; Holmberg, L; Liuba, P; Pesonen, E; Truedsson, L; Ylä-Herttuala, S | 1 |
| Dou, D; Gao, Y; Qi, H; Qin, X; Raj, JU; Xu, H; Zheng, X | 1 |
| Dou, D; Gao, Y; Liu, L; Qi, H; Qin, X; Raj, JU; Zheng, X | 1 |
| Wimalawansa, SJ | 1 |
| Bai, YP; Chen, YR; Jiang, DJ; Li, YJ; Shi, RZ; Tang, ZY; Xiao, HB; Zhang, GG | 1 |
| Ashina, M; Casari, G; Hansen, JM; Marconi, R; Olesen, J; Thomsen, LL | 1 |
| Ashina, M; Hansen, JM; Olesen, J; Thomsen, LL | 1 |
| Beretta, M; Goessler, W; Gruber, K; Keung, WM; Koesling, D; Kollau, A; Mayer, B; Russwurm, M; Schmidt, K | 1 |
| Huang, Y; Lau, CW; Lee, VW; Leung, FP; Liu, CQ; Lu, L; Yao, X | 1 |
| Addanki, V; Fung, HL; Tsou, PS | 1 |
| Dun, Y; Hao, Y; Li, J; Yang, C; Zhang, M; Zhang, Y | 1 |
| Movsesian, MA; Stehlik, J | 1 |
| Addanki, V; Fung, HL; Haas, JA; Page, NA; Tsou, PS | 1 |
| Anderson, DJ; Bennett, BM; Ji, Y | 1 |
| Chen, A; Chen, J; Chen, YR; Fu, QM; Jia, SJ; Li, SX; Li, XH; Li, YJ; Shi, RZ; Tan, GS; Zhang, GG | 1 |
| Bult, H; Fransen, P; Herman, AG; Van der Donckt, C; Van Hove, CE | 1 |
| Dou, D; Gao, Y; Guo, Y; Ma, H; Ying, L; Yu, X; Zheng, X | 1 |
| Hughes, DA; Kroon, PA; Liu, XH; Needs, PW; Rayment, S; Suri, S; Taylor, MA; Tribolo, S; Wilson, VG | 1 |
| Ahmed, F; Chawla, V; Garg, A; Khandelwal, M; Verma, AP | 1 |
| Bonadei, I; Caretta, G; Cas, LD; Raddino, R; Teli, M; Vizzardi, E | 1 |
| Olesen, J | 1 |
| Funae, Y; Hirai, H; Minamiyama, Y; Nakahira, A; Okada, S; Sasaki, Y; Suehiro, S; Takemura, S | 1 |
| Irvine, JC; Kemp-Harper, BK; Widdop, RE | 1 |
| Bajza, A; Németh, J; Peitl, B; Szilvássy, Z | 1 |
| Dou, D; Gao, Y; He, Q; Liu, J; Xu, X; Ye, L; Ying, L; Yu, X | 1 |
| Dou, D; Gao, Y; Guo, Y; Liu, J; Xu, X; Ying, L; Yu, X | 1 |
| Apostolova, N; Garcia-Bou, R; Herance, R; Hernandez-Mijares, A; Rocha, M; Victor, VM | 1 |
| Gorren, AC; Kolesnik, B; Mayer, B; Neubauer, A; Schmidt, K; Stasch, JP; Werner, ER | 1 |
| Capogrossi, MC; Castellano, S; Colussi, C; Farsetti, A; Gaetano, C; Illi, B; Mai, A; Mattiussi, S; Rosati, J; Sbardella, G; Scopece, A; Spallotta, F; Vitale, S | 1 |
| Austin, SA; d'Uscio, LV; Katusic, ZS | 1 |
| Bennett, BM; D'Souza, Y; Ji, Y | 1 |
| Carresi, C; Dagostino, C; Giancotti, LA; Gliozzi, M; Gratteri, S; Malara, N; Mollace, V; Muscoli, C; Muscoli, S; Musolino, V; Palma, E; Romeo, F; Sacco, I; Salvemini, D; Visalli, V; Vitale, C | 1 |
| Carøe Nordgaard, J; Gammeltoft, S; Kruse, LS; Kruuse, CR | 1 |
| Andrews, KL; Chin-Dusting, JP; Farry, J; Jefferis, AM; Kemp-Harper, BK; Lumsden, NG | 1 |
| Gao, X; Liu, X; Ma, X; Qian, Y; Sun, Y; Tan, W; Wang, T; Wang, X; Zhou, Q | 1 |
| Alogna, A; Blankenberg, S; Hamdani, N; Kloth, B; Linke, WA; Maechler, H; Manninger, M; Marsche, G; Pieske, BM; Post, H; Schwarzl, M; Steendijk, P; Tschöpe, C; Verderber, J; Westermann, D; Zirngast, B; Zweiker, D | 1 |
| Adriaenssens, T; Belmans, A; Bennett, J; Bloch, KD; Bogaert, J; Claus, P; Desmet, W; Dubois, C; Durak, M; Goetschalckx, K; Janssens, SP; Lech, P; Lux, A; Merkely, B; Pokreisz, P; Sinnaeve, P; Szelid, Z; Toth, A; Van de Werf, F; Vandenberghe, K; Vermeersch, P; Vranckx, P; Zalewski, J; Zmudka, K | 1 |
| Ayalasomayajula, S; Buchbjerg, J; Golor, G; Hinder, M; Langenickel, TH; Pal, P; Prescott, MF; Schuehly, U; Sunkara, G | 1 |
| Barsoum, IB; Graham, CH; Kim, J; Loh, H; Paré, JF; Siemens, DR | 1 |
14 review(s) available for nitroglycerin and cyclic gmp
| Article | Year |
|---|---|
Actions of nicorandil on vascular smooth muscles.
Topics: Action Potentials; Animals; Calcium; Cyclic GMP; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Vasoconstriction; Vasodilator Agents | 1987 |
Direct vasodilators with unknown modes of action: the nitro-compounds and hydralazine.
Topics: Animals; Calcium; Cell Membrane; Cyclic GMP; Humans; Hydralazine; Muscle Contraction; Muscle Proteins; Nitro Compounds; Nitroglycerin; Nitroprusside; Nitroso Compounds; Sodium Nitrite; Vasodilator Agents | 1984 |
Some pharmacological properties of organic nitrates.
Topics: Angina Pectoris; Animals; Arterioles; Coronary Circulation; Coronary Vessels; Cyclic AMP; Cyclic GMP; Drug Tolerance; Humans; Inactivation, Metabolic; Isosorbide Dinitrate; Liver; Muscle, Smooth, Vascular; Myocardium; Nitrates; Nitroglycerin; Oxyhemoglobins; Vasodilation; Venous Pressure | 1984 |
Glyceryl trinitrate enhances the adenosine-induced inhibition of platelet responses: a mechanism potentially involved in the in vivo anti-aggregating effects of organic nitrates.
Topics: Adenosine; Adult; Cyclic AMP; Cyclic GMP; Dipyridamole; Drug Interactions; Humans; Male; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1995 |
[The Nobel Prize 1998 in physiology or medicine. Nitrogen oxide as a signal molecule in the cardiovascular system].
Topics: Animals; Cardiovascular Physiological Phenomena; Cyclic GMP; Endothelium, Vascular; History, 20th Century; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nobel Prize; United States | 1998 |
[Pharmacological profiles of sildenafil (VIAGRA) in the treatment of erectile dysfunction: efficacy and drug interaction with nitrate].
Topics: Animals; Blood Pressure; Cyclic GMP; Dogs; Drug Interactions; Erectile Dysfunction; Humans; Male; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Penile Erection; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Rabbits; Sildenafil Citrate; Sulfones | 1999 |
[Nitic oxide and natriuretic peptides].
Topics: Adenylyl Cyclase Inhibitors; Aspirin; Cyclic GMP; Drug Design; Humans; Natriuretic Agents; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfhydryl Compounds; Sulfones | 2000 |
The role of nitric oxide synthase/nitric oxide in vascular smooth muscle control.
Topics: Administration, Inhalation; Amyl Nitrite; Arginine; Calcium Signaling; Cardiopulmonary Bypass; Cyclic GMP; Endothelium, Vascular; Humans; Infusions, Intravenous; Intraoperative Care; Isoenzymes; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Vascular Resistance | 2000 |
Glyceryl trinitrate and acute uterine relaxation: a literature review.
Topics: Animals; Cyclic GMP; Female; Hemodynamics; Humans; Muscle Relaxation; Nitric Oxide; Nitroglycerin; Obstetric Labor Complications; Pregnancy; Uterine Contraction; Uterus; Vasodilator Agents | 2001 |
Nitrates and NO release: contemporary aspects in biological and medicinal chemistry.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Cations; Cyclic GMP; Drug Design; Drug Tolerance; Endothelium, Vascular; Free Radicals; Guanylate Cyclase; Humans; Molecular Structure; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroglycerin; Oxidation-Reduction; Sulfhydryl Compounds; Vasodilator Agents | 2004 |
Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenergic alpha-Antagonists; Arteriosclerosis; Blood Pressure; Carbolines; Contraindications; Coronary Disease; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Interactions; Endothelium, Vascular; Erectile Dysfunction; Heart Rate; Humans; Hypotension; Imidazoles; Isosorbide Dinitrate; Male; Molecular Structure; Myocardial Infarction; Nitric Oxide Donors; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilation; Vasodilator Agents | 2004 |
Organic nitrates in cardiovascular disease.
Topics: Angina, Unstable; Animals; Cardiovascular Diseases; Cyclic GMP; Enalapril; Endothelium, Vascular; Hemodynamics; Humans; Myocardial Infarction; Nitrates; Nitric Oxide; Nitroglycerin; Platelet Aggregation | 2005 |
Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humans.
Topics: Animals; Bone and Bones; Bone Density; Clinical Trials as Topic; Cyclic GMP; Estrogens; Female; Humans; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Osteoporosis; Osteoprotegerin; RANK Ligand; Treatment Outcome | 2007 |
Nitric oxide-related drug targets in headache.
Topics: Cyclic GMP; Headache; Humans; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones | 2010 |
23 trial(s) available for nitroglycerin and cyclic gmp
| Article | Year |
|---|---|
Rapid development of nitrate tolerance in healthy volunteers: assessment using spectral analysis of short-term blood pressure and heart rate variability.
Topics: Adult; Blood Pressure; Cross-Over Studies; Cyclic GMP; Drug Tolerance; Heart Rate; Humans; Male; Nitroglycerin; Renin; Signal Processing, Computer-Assisted | 1994 |
Effect of low dose of dipyridamole on glyceryl trinitrate tolerance in healthy volunteers.
Topics: Adult; Blood Pressure; Cyclic GMP; Dipyridamole; Double-Blind Method; Drug Tolerance; Female; Heart Rate; Humans; Male; Nitroglycerin | 1993 |
Comparison of hemodynamic effects and plasma cyclic guanosine monophosphate of nicorandil and nitroglycerin in patients with congestive heart failure.
Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Cyclic GMP; Female; Heart Failure; Hemodynamics; Humans; Least-Squares Analysis; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Pulmonary Wedge Pressure; Regression Analysis; Vasodilator Agents | 1995 |
The anti-inflammatory and analgesic action of transdermal glyceryltrinitrate in the treatment of infusion-related thrombophlebitis.
Topics: Administration, Cutaneous; Adult; Aged; Cyclic GMP; Double-Blind Method; Female; Forearm; Humans; Infusions, Intravenous; Male; Middle Aged; Nitroglycerin; Prospective Studies; Thrombosis; Time Factors | 1993 |
Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance.
Topics: Administration, Oral; Adult; Aged; Antioxidants; Blood Platelets; Cyclic GMP; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Forearm; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Plethysmography; Regional Blood Flow; Vasodilator Agents; Vitamin E | 1997 |
Randomized, double-blind, placebo-controlled study of ascorbate on the preventive effect of nitrate tolerance in patients with congestive heart failure.
Topics: Aged; Ascorbic Acid; Blood Platelets; Blood Pressure; Cyclic GMP; Double-Blind Method; Drug Tolerance; Female; Heart Failure; Humans; Infusions, Intravenous; Male; Nitroglycerin; Vitamin E | 1998 |
Randomized, double-blind, placebo-controlled study of the preventive effect of supplemental oral vitamin C on attenuation of development of nitrate tolerance.
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cyclic GMP; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Plethysmography; Vasodilator Agents | 1998 |
Preventive effects of angiotensin-converting enzyme inhibitors on nitrate tolerance during continuous transdermal application of nitroglycerin in patients with chronic heart failure.
Topics: Administration, Cutaneous; Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Platelets; Blood Pressure; Body Weight; Chronic Disease; Cyclic GMP; Drug Tolerance; Female; Forearm; Heart Failure; Heart Rate; Hematocrit; Humans; Male; Middle Aged; Nitrates; Nitroglycerin; Norepinephrine; Regional Blood Flow; Renin; Systole; Vasodilator Agents | 1998 |
Dietary supplement with vitamin C prevents nitrate tolerance.
Topics: Adult; Aged; Aged, 80 and over; Ascorbic Acid; Blood Platelets; Blood Pressure; Calcium; Cyclic GMP; Diet; Drug Tolerance; Female; Humans; Male; Middle Aged; Nitroglycerin; Superoxides | 1998 |
Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure.
Topics: Adrenergic Antagonists; Aged; Blood Flow Velocity; Blood Platelets; Blood Pressure; Carbazoles; Carvedilol; Chronic Disease; Cyclic GMP; Double-Blind Method; Doxazosin; Drug Hypersensitivity; Drug Therapy, Combination; Female; Follow-Up Studies; Forearm; Heart Failure; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Nitroglycerin; Propanolamines; Vasodilator Agents | 1998 |
Preventive effects of carvedilol on nitrate tolerance--a randomized, double-blind, placebo-controlled comparative study between carvedilol and arotinolol.
Topics: Adrenergic Antagonists; Adult; Aged; Blood Flow Velocity; Blood Platelets; Blood Pressure; Carbazoles; Carvedilol; Cyclic GMP; Double-Blind Method; Drug Hypersensitivity; Drug Therapy, Combination; Female; Follow-Up Studies; Forearm; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nitroglycerin; Propanolamines; Vasodilator Agents | 1998 |
Platelet cyclic GMP responses to nitroglycerin.
Topics: Administration, Cutaneous; Administration, Sublingual; Adult; Analysis of Variance; Blood Platelets; Blood Pressure; Cyclic GMP; Humans; Male; Nitroglycerin | 2000 |
Diurnal variation of flow-mediated vasodilation in healthy premenopausal women.
Topics: Adult; Blood Pressure; Brachial Artery; Catecholamines; Circadian Rhythm; Cyclic GMP; Endothelium, Vascular; Female; Heart Rate; Humans; Hydrocortisone; Lipids; Nitrates; Nitric Oxide; Nitroglycerin; Premenopause; Reference Values; Vasodilation; Vasodilator Agents | 2000 |
Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment.
Topics: Aged; Blood Vessels; Cell Adhesion Molecules; Coronary Artery Bypass; Coronary Disease; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Female; Guanylate Cyclase; Humans; Immunohistochemistry; In Vitro Techniques; Male; Mammary Arteries; Microfilament Proteins; Middle Aged; Nitric Oxide; Nitroglycerin; Phosphoproteins; Phosphorylation; Radial Artery; Receptors, Cytoplasmic and Nuclear; Saphenous Vein; Signal Transduction; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2002 |
Platelet nitric oxide and superoxide release during the development of nitrate tolerance: effect of supplemental ascorbate.
Topics: Adult; Antioxidants; Ascorbic Acid; Blood Platelets; Cross-Over Studies; Cyclic GMP; Double-Blind Method; Drug Tolerance; Free Radicals; Hemodynamics; Humans; Male; Middle Aged; NAD; NADPH Oxidases; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroglycerin; Superoxides; Time Factors; Vasodilator Agents | 2002 |
Interaction of sildenafil with cAMP-mediated vasodilation in vivo.
Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Brachial Artery; Cyclic AMP; Cyclic GMP; Forearm; Heart Rate; Hemodynamics; Humans; Isoproterenol; Male; Milrinone; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Regional Blood Flow; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2002 |
Effect of transdermal nitroglycerin on inflammatory mediators in patients with peripheral atherosclerotic vascular disease.
Topics: Administration, Cutaneous; Adult; Aged; Anti-Inflammatory Agents; Arteriosclerosis; Biomarkers; C-Reactive Protein; Cyclic GMP; Double-Blind Method; E-Selectin; Female; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Middle Aged; Nitrates; Nitrites; Nitroglycerin; Peripheral Vascular Diseases; Pilot Projects; Statistics, Nonparametric; Vascular Cell Adhesion Molecule-1; Vasculitis; Vasodilator Agents | 2003 |
Statin therapy improves brachial artery vasodilator function in patients with Type 1 diabetes and microalbuminuria.
Topics: Adolescent; Adult; Aged; Albuminuria; Apolipoproteins B; Atorvastatin; Brachial Artery; Cholesterol, LDL; Cross-Over Studies; Cyclic GMP; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Linear Models; Lipoproteins, LDL; Male; Middle Aged; Nitroglycerin; Pyrroles; Regional Blood Flow; Statistics, Nonparametric; Vasodilation; Vasodilator Agents | 2005 |
Cyclic guanosine monophosphate phosphodiesterase-5 inhibitor promotes an endothelium NO-dependent-like vasodilation in patients with refractory hypertension.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelium; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2007 |
Familial hemiplegic migraine type 1 shows no hypersensitivity to nitric oxide.
Topics: Adult; Cyclic GMP; Female; Humans; Male; Middle Aged; Migraine with Aura; Nitric Oxide; Nitroglycerin; Signal Transduction; Vasodilator Agents | 2008 |
The effect of transdermal nitroglycerine on intrathecal fentanyl with bupivacaine for postoperative analgesia following gynaecological surgery.
Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Bupivacaine; Cyclic GMP; Double-Blind Method; Female; Fentanyl; Humans; Hysterectomy; Injections, Spinal; Middle Aged; Nitric Oxide; Nitroglycerin; Pain, Postoperative | 2010 |
Nitric oxide for inhalation in ST-elevation myocardial infarction (NOMI): a multicentre, double-blind, randomized controlled trial.
Topics: Administration, Inhalation; Aged; Cyclic GMP; Double-Blind Method; Female; Free Radical Scavengers; Heart Ventricles; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Mortality; Myocardial Reperfusion Injury; Nitric Oxide; Nitroglycerin; Organ Size; Oxygen Inhalation Therapy; Patient Readmission; Recurrence; ST Elevation Myocardial Infarction; Stroke; Vasodilator Agents; Ventricular Dysfunction, Left | 2018 |
Pharmacodynamic interaction between intravenous nitroglycerin and oral sacubitril/valsartan (LCZ696) in healthy subjects.
Topics: Administration, Oral; Adult; Aminobutyrates; Antihypertensive Agents; Biomarkers; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Dosage Calculations; Drug Interactions; Drug Monitoring; Female; Healthy Volunteers; Humans; Infusions, Intravenous; Male; Middle Aged; Nitroglycerin; Tetrazoles; Valsartan | 2018 |
336 other study(ies) available for nitroglycerin and cyclic gmp
| Article | Year |
|---|---|
Decreased vascular relaxation in hypertension.
Topics: Adenosine; Animals; Aorta, Thoracic; Bucladesine; Cyclic GMP; Female; Hypertension, Renal; Isoproterenol; Male; Muscle Contraction; Nitroglycerin; Rats; Rats, Inbred Strains; Serotonin; Vasomotor System | 1976 |
Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.
Topics: Animals; Azides; Cattle; Cyclic AMP; Cyclic GMP; Female; Ferricyanides; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Nitroglycerin; Nitroprusside; Rats; Species Specificity | 1977 |
Relationship between nitroglycerin, cyclic GMP and relaxation of vascular smooth muscle.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroglycerin | 1979 |
Effects of coronary vasodilator on cyclic nucleotides. The concentrations of cyclic AMP and cyclic GMP in canine coronary artery and left ventricular muscle following the administration of various coronary vasodilators.
Topics: Amyl Nitrite; Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Diltiazem; Dipyridamole; Dogs; Heart Ventricles; Isosorbide Dinitrate; Myocardium; Nifedipine; Nitroglycerin; Papaverine; Radioimmunoassay; Vasodilator Agents | 1979 |
Molecular mechanism of action of nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Niacinamide; Nicorandil; Nitroglycerin; Nitroprusside; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Impaired vasodilatory response to atrial natriuretic peptide during atherosclerosis progression.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteriosclerosis; Atrial Natriuretic Factor; Cholesterol; Cyclic GMP; Endothelium, Vascular; Female; Hyperlipidemias; Isoproterenol; Male; Nitroglycerin; Rabbits; Triglycerides; Vasodilation | 1992 |
Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by Escherichia coli lipopolysaccharide.
Topics: Animals; Arginine; Blood Pressure; Cattle; Cells, Cultured; Cyclic GMP; Cycloheximide; Endothelium, Vascular; Escherichia coli; Hemodynamics; Humans; In Vitro Techniques; Lipopolysaccharides; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; omega-N-Methylarginine; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats | 1992 |
Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Electric Stimulation; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitroglycerin; Nitroprusside; Penicillamine; Penis; Purinones; Rabbits; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1992 |
Nifedipine-resistant Ca(++)-induced contraction in tail artery of spontaneously hypertensive rats.
Topics: Animals; Arteries; Blood Pressure; Calcium; Cyclic GMP; Egtazic Acid; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin | 1992 |
Vasorelaxation by nitroglycerin of the isolated porcine coronary artery during hypoxia.
Topics: Animals; Coronary Vessels; Cyclic GMP; Hypoxia; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Swine | 1992 |
Nitrovasodilators relax arterial smooth muscle by decreasing [Ca2+]i and uncoupling stress from myosin phosphorylation.
Topics: Animals; Calcium; Carotid Arteries; Cyclic AMP; Cyclic GMP; Histamine; Muscle, Smooth, Vascular; Myosins; Nitro Compounds; Nitroglycerin; Nitroprusside; Osmolar Concentration; Phosphorylation; Swine; Vasodilation; Vasodilator Agents | 1992 |
[Mechanism of cellular action of nitrate derivatives].
Topics: Cyclic GMP; Humans; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitroglycerin; Protein Kinases; Vasodilation | 1992 |
Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin.
Topics: Animals; Aorta; Cyclic GMP; Drug Interactions; In Vitro Techniques; Methylene Blue; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Penicillamine; Platelet Aggregation; Pyocyanine; Rabbits; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Vasodilator Agents | 1992 |
Contribution of cyclic GMP formation to KRN2391-induced relaxation in coronary artery of the pig.
Topics: Animals; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Niacinamide; Nicorandil; Nitroglycerin; Pyridines; Swine; Vasodilation; Vasodilator Agents | 1992 |
Cultured astrocytoma cells generate a nitric oxide-like factor from endogenous L-arginine and glyceryl trinitrate: effect of E. coli lipopolysaccharide.
Topics: Arginine; Astrocytoma; Cyclic GMP; Escherichia coli; Humans; Indomethacin; Lipopolysaccharides; Nitric Oxide; Nitroglycerin; omega-N-Methylarginine; Platelet Aggregation; Tumor Cells, Cultured | 1992 |
Prolonged exposure to catecholamines enhances sensitivity of smooth muscle relaxation induced by sodium nitroprusside and atriopeptin.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Norepinephrine; Peptide Fragments; Rats; Rats, Inbred Strains | 1992 |
Cytochrome P-450 mediates bioactivation of organic nitrates.
Topics: Animals; Cell Line; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fibroblasts; Guanylate Cyclase; Liver; Lung; Male; Methylcholanthrene; Nitroglycerin; Proadifen; Rats; Rats, Inbred Strains | 1992 |
Inhibition of nitrovasodilator- and acetylcholine-induced relaxation and cyclic GMP accumulation by the cytochrome P-450 substrate, 7-ethoxyresorufin.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Aorta; Biotransformation; Cyclic GMP; Cytochrome P-450 Enzyme System; Drug Interactions; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxazines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1992 |
The metabolism of glyceryl trinitrate to nitric oxide in the macrophage cell line J774 and its induction by Escherichia coli lipopolysaccharide.
Topics: Amino Acid Oxidoreductases; Animals; Cell Line; Cyclic GMP; Cycloheximide; Drug Tolerance; Escherichia coli; Hot Temperature; Humans; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroglycerin; Oxyhemoglobins; Platelet Aggregation Inhibitors | 1992 |
Comparison of cyclic GMP in human internal mammary artery and saphenous vein: implications for coronary artery bypass graft patency.
Topics: Acetylcholine; Bradykinin; Coronary Artery Bypass; Culture Techniques; Cyclic GMP; Endothelium, Vascular; Graft Occlusion, Vascular; Humans; Mammary Arteries; Nitroglycerin; Saphenous Vein; Substance P; Vascular Patency | 1992 |
Developmental aspects of endothelial function.
Topics: Adenosine Diphosphate; Aging; Animals; Animals, Newborn; Calcimycin; Cerebral Arteries; Cerebrovascular Circulation; Cyclic GMP; Endothelium, Vascular; Fetus; Humans; Nitroglycerin; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sheep; Vasoconstriction; Vasodilation | 1991 |
Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation.
Topics: Acetylcholine; Animals; Cattle; Cells, Cultured; Coronary Vessels; Cyclic GMP; Ditiocarb; Endothelium, Vascular; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Superoxide Dismutase | 1991 |
Role of nitric oxide in neurally induced cerebroarterial relaxation.
Topics: Animals; Arginine; Calcimycin; Cerebral Arteries; Cyclic GMP; Dogs; Female; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons; Nicotine; Nitric Oxide; Nitroarginine; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1991 |
Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells.
Topics: Animals; Aorta, Thoracic; Biotransformation; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Hot Temperature; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Radioimmunoassay; Swine; Temperature | 1991 |
Tissue levels of glyceryl trinitrate and cGMP after in vivo administration in rat, and the effect of tolerance development.
Topics: Animals; Aorta; Brain; Cyclic GMP; Drug Tolerance; Male; Myocardium; Nitroglycerin; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Stimulative effect of sodium nitroprusside on peristaltic reflex in isolated guinea pig ileal segments.
Topics: Animals; Arginine; Cyclic GMP; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Methylene Blue; Muscle Contraction; Neurons; Nitric Oxide; Nitroarginine; Nitroglycerin; Nitroprusside; Peristalsis; Stimulation, Chemical | 1991 |
Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Activation; Esters; Female; Guanylate Cyclase; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitric Oxide; Nitroglycerin; Stimulation, Chemical; Vasodilator Agents | 1991 |
Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Drug Synergism; Female; Guanylate Cyclase; Hemoglobins; Isoproterenol; Male; Methylene Blue; Muscle Relaxation; Nitroglycerin; Nitroprusside; Penicillamine; Purinones; S-Nitroso-N-Acetylpenicillamine; Time Factors; Trachea; Vasodilator Agents | 1991 |
Glyceryl trinitrate increases platelet cyclic GMP after metabolism in fibroblasts.
Topics: Animals; Biotransformation; Blood Platelets; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Fibroblasts; Guanylate Cyclase; Humans; Nitric Oxide; Nitroglycerin; Radioimmunoassay; Superoxide Dismutase | 1991 |
Biotransformation of glyceryl trinitrate and elevation of cyclic GMP precede glyceryl trinitrate-induced vasodilation.
Topics: Animals; Aorta, Thoracic; Biotransformation; Cattle; Cyclic GMP; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Pulmonary Artery; Pulmonary Veins; Rabbits; Vasodilator Agents | 1990 |
Cyclic GMP mediates SIN-1-induced inhibition of human polymorphonuclear leukocytes.
Topics: 1-Methyl-3-isobutylxanthine; Cyanides; Cyclic AMP; Cyclic GMP; Glucuronidase; Humans; In Vitro Techniques; Macrophage Activation; Methylene Blue; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroglycerin; Nitroprusside; Nitrosamines; Vasodilator Agents | 1990 |
Captopril-induced reversal of nitroglycerin tolerance: role of sulfhydryl group vs. ACE-inhibitory activity.
Topics: Acetylcholine; Acetylcysteine; Animals; Aorta; Captopril; Cyclic GMP; Drug Tolerance; Enalaprilat; Nitroglycerin; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Vasodilation | 1991 |
Characteristics of the vasorelaxing action of (3E)-4-ethyl-2-hydroximino-5-nitro-3-hexamide FK409, a new vasodilator isolated from microbial sources, in isolated rabbit arteries.
Topics: Animals; Arteries; Caffeine; Calcium; Cyclic GMP; Hemoglobins; Histamine; In Vitro Techniques; Inositol Phosphates; Male; Methylene Blue; Nitro Compounds; Nitroglycerin; Norepinephrine; Purinones; Rabbits; Serotonin; Vasoconstriction; Vasodilator Agents | 1991 |
Reduced nitric oxide release causes nitrate tolerance in the intact coronary circulation.
Topics: Animals; Bradykinin; Cell Line; Coronary Vessels; Cyclic GMP; Drug Tolerance; Fibroblasts; Heart; Iloprost; Lung; Molsidomine; Myocardium; Nitrates; Nitric Oxide; Nitroglycerin; Rabbits; Rats; Vasodilator Agents | 1991 |
Nicorandil-induced vasorelaxation: functional evidence for K+ channel-dependent and cyclic GMP-dependent components in a single vascular preparation.
Topics: Animals; Calcium; Cyclic GMP; Drug Tolerance; Mesenteric Arteries; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Rabbits; Vasodilator Agents | 1991 |
Endothelial function of human gastroepiploic artery. Implications for its use as a bypass graft.
Topics: Arginine; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; In Vitro Techniques; Indomethacin; Nitroglycerin; omega-N-Methylarginine; Stomach; Substance P; Vascular Patency; Vasodilation | 1991 |
Nitric oxide from vascular smooth muscle cells: regulation of platelet reactivity and smooth muscle cell guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Atrial Natriuretic Factor; Blood Platelets; Cattle; Cyclic GMP; Cycloheximide; Escherichia coli; Guanylate Cyclase; Humans; In Vitro Techniques; Lipopolysaccharides; Macrophages; Mice; Monocytes; Muscle, Smooth; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; omega-N-Methylarginine; Superoxide Dismutase; Thrombin | 1991 |
Modification of nitrovasodilator effects on vascular smooth muscle by exogenous GTP and guanosine.
Topics: Animals; Cyclic GMP; Guanosine; Guanosine Triphosphate; In Vitro Techniques; Male; Molsidomine; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Rats, Inbred Strains; Sodium Nitrite; Vasodilation | 1991 |
Effects of nitroglycerin on ATP-induced Ca(++)-mobilization, Ca(++)-activated K channels and contraction of cultured smooth muscle cells of porcine coronary artery.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Coronary Vessels; Cyclic GMP; Cytosol; Intracellular Fluid; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Potassium Channels; Swine | 1991 |
Recovery of vascular smooth muscle relaxation from nitroglycerin-induced tolerance following a drug-free interval. A time-course in vitro study.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Epinephrine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Nitroprusside; omega-N-Methylarginine; Ornithine; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Nitrovasodilator-induced inhibition of LTB4 release from human PMN may be mediated by cyclic GMP.
Topics: Cyclic GMP; Humans; Leukotriene B4; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroglycerin; Nitrosamines; Vasodilator Agents | 1990 |
Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Cell Division; Cell Line; Cricetinae; Cricetulus; Cyclic GMP; DNA; Endothelins; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Rats; Rats, Inbred Strains; Vasodilator Agents | 1990 |
Inhibitors of cytochrome P-450 reduce cyclic GMP stimulation by glyceryl trinitrate in LLC-PK1 kidney epithelial cells.
Topics: Animals; Cell Line; Cimetidine; Cyclic GMP; Cytochrome P-450 Enzyme Inhibitors; Epithelium; Kidney; Miconazole; Nitroglycerin; Ranitidine; Swine | 1990 |
Preferential proximal coronary dilation by activators of guanylate cyclase in awake dogs.
Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dogs; Enzyme Activation; Guanylate Cyclase; Nitroglycerin; Vasodilation; Wakefulness | 1990 |
Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure.
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output, Low; Cyclic GMP; Female; Forearm; Heart Rate; Humans; Injections, Intra-Arterial; Male; Middle Aged; Nitroglycerin; Regional Blood Flow; Vasodilation; Veins | 1990 |
Studies of the effect of glyceryl trinitrate and cyclic GMP on calcium turnover in bovine mesenteric artery.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium-Transporting ATPases; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; Inositol Phosphates; Mesenteric Arteries; Microsomes; Muscle, Smooth, Vascular; Nitroglycerin | 1990 |
Pharmacological regulation of the circulation of bone.
Topics: Acetylcholine; Animals; Atropine; Bone and Bones; Bucladesine; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Isoproterenol; Methoxamine; Nitroglycerin; Peptides; Propanolamines; Prostaglandin Endoperoxides, Synthetic; Receptors, Drug; Regional Blood Flow; Tibia; Vasoconstrictor Agents; Vasodilator Agents | 1990 |
Effects of methylene blue on hypoxic cerebral vasodilatation in the rabbit.
Topics: Animals; Cerebrovascular Circulation; Cyclic GMP; Drug Interactions; Hypoxia; Injections, Intravenous; Male; Methylene Blue; Muscle, Smooth, Vascular; Nitroglycerin; Papaverine; Rabbits; Vasodilation | 1990 |
Superoxide anion inhibits cGMP-associated bovine pulmonary arterial relaxation.
Topics: Aminoquinolines; Animals; Anions; Cattle; Cyclic GMP; Ditiocarb; Hydrogen Peroxide; Hypoxia; Isoproterenol; Nitroglycerin; Oxygen; Oxygen Consumption; Pulmonary Artery; Superoxides; Vasodilation | 1990 |
Atrial natriuretic peptide, nitroglycerine, and nitroprusside reduce basal and stimulated endothelin production from cultured endothelial cells.
Topics: Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Nitroglycerin; Nitroprusside; Papaverine; Vasodilator Agents | 1990 |
Studies of the desensitization of atrial natriuretic factor and nitroglycerin in rat aortic rings.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Down-Regulation; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Norepinephrine; Rats; Rats, Inbred Strains | 1990 |
Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cyclic GMP; Drug Synergism; Endothelium; Hemoglobins; In Vitro Techniques; Isoproterenol; Male; Nitric Oxide; Nitroglycerin; Papaverine; Phosphodiesterase Inhibitors; Purinones; Rabbits; Rats; Rats, Inbred Strains; Vasodilation; Vasodilator Agents | 1986 |
Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.
Topics: Acetylcholine; Animals; Aorta; Arteriosclerosis; Calcimycin; Coronary Vessels; Cyclic GMP; Endothelium; Histamine; Humans; Nitric Oxide; Nitroglycerin; Rabbits; Receptors, Muscarinic; Substance P; Vasodilation; Vasodilator Agents | 1987 |
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine | 1987 |
Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Calcimycin; Coronary Vessels; Cyclic GMP; Male; Nitroglycerin; Rats; Rats, Inbred Strains; Vasodilation | 1987 |
Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Endothelium, Vascular; Histamine; Male; Muscle Contraction; Muscle Relaxation; Nitroglycerin; Nitroprusside; Norepinephrine; Propylene Glycols; Rats; Rats, Inbred Strains; Vasodilation | 1987 |
Comparison of the inhibitory effects of nicorandil, nitroglycerin and isosorbide dinitrate on vascular smooth muscle of rabbit aorta.
Topics: Animals; Aorta; Calcium; Cyclic GMP; In Vitro Techniques; Ion Channels; Isosorbide Dinitrate; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Rabbits | 1987 |
Cyclic GMP in nicorandil-induced vasodilatation and tolerance development.
Topics: Acetylcysteine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents | 1987 |
Methylene blue selectively inhibits pulmonary vasodilator responses in cats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Angiotensin II; Animals; Blood Pressure; Bradykinin; Cats; Cyclic GMP; Epinephrine; Female; Isoproterenol; Male; Methylene Blue; Nitroglycerin; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Pulmonary Circulation; Reference Values; Vasodilation | 1989 |
Generation of NO from molsidomine (SIN-1) in vitro and its relationship to changes in coronary vessel tone.
Topics: Animals; Cells, Cultured; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Iloprost; Molsidomine; Nitric Oxide; Nitroglycerin; Oxyhemoglobins; Rabbits; Vasodilator Agents | 1989 |
Tolerance and cross-tolerance between SIN-1 and nitric oxide in bovine coronary arteries.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1989 |
Effects of nitroprusside and nitroglycerin on cGMP content and PGI2 formation in aorta and vena cava.
Topics: Animals; Aorta; Cyclic GMP; Epoprostenol; Ferricyanides; Male; Nitroglycerin; Nitroprusside; Rats; Rats, Inbred Strains; Venae Cavae | 1989 |
Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines.
Topics: Animals; Biotransformation; Cell Line; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Fibroblasts; Kidney; Kinetics; Muscle, Smooth, Vascular; Nitroglycerin; Tritium | 1989 |
Tissue distribution of glyceryl trinitrate and the effect on cGMP levels in rat.
Topics: Adipose Tissue; Animals; Brain Chemistry; Cyclic GMP; Half-Life; Male; Myocardium; Nitroglycerin; Rats; Rats, Inbred Strains; Tissue Distribution | 1989 |
[Two types of relaxation responses mediated by cyclic GMP in cerebral arteries].
Topics: Adult; Aged; Animals; Basilar Artery; Calcimycin; Cerebral Arteries; Child, Preschool; Cyclic GMP; Dogs; Endothelium, Vascular; Humans; Jugular Veins; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Vasodilation | 1989 |
Effect of pertussis toxin and the cGMP lowering agent LY83583 on the relaxation induced by nitrates in isolated bovine mesenteric artery. A comparison between glyceryl trinitrate, isosorbide dinitrate and isosorbide 5-mononitrate.
Topics: Aminoquinolines; Animals; Cattle; Cyclic GMP; Isosorbide Dinitrate; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Pertussis Toxin; Vascular Resistance; Virulence Factors, Bordetella | 1989 |
The role of nitric oxide formation in organic nitrate-induced vasodilation and organic nitrate tolerance.
Topics: Animals; Aorta; Biotransformation; Cyclic GMP; Drug Tolerance; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Prodrugs; Rabbits; Vasodilation | 1989 |
[Isolated human venous segments as a model for the study of problems of nitrate tolerance].
Topics: Acetylcysteine; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitroglycerin; Saphenous Vein; Vascular Resistance; Vasodilation | 1989 |
Effects of nicorandil on cytosolic calcium concentrations in quin2-loaded rat aortic vascular smooth muscle cells in primary culture.
Topics: Aminoquinolines; Animals; Aorta; Caffeine; Calcium; Cells, Cultured; Cyclic GMP; Cytosol; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
Guanosine 3':5'cyclic monophosphate and activators of guanylate cyclase inhibit secretagogue-induced corticotropin release by rat anterior pituitary cells.
Topics: Adrenocorticotropic Hormone; Animals; Atrial Natriuretic Factor; Corticotropin-Releasing Hormone; Cyclic GMP; Dibutyryl Cyclic GMP; Enzyme Activation; Female; Guanylate Cyclase; Nitroglycerin; Nitroprusside; Pituitary Gland, Anterior; Potassium Chloride; Rats; Rats, Inbred Strains; Vasopressins | 1989 |
Endothelium- and sydnonimine-induced responses of native and cultured aortic smooth muscle cells are not impaired by nitroglycerin tolerance.
Topics: Animals; Aorta, Thoracic; Biological Factors; Cattle; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Enzyme Activation; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Oxadiazoles; Rabbits; Vasodilation | 1989 |
Clinical tolerance to nitroglycerin is due to impaired biotransformation of nitroglycerin and biological counterregulation, not to desensitization of guanylate cyclase.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Guanylate Cyclase; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Prodrugs; Rabbits; Vascular Resistance; Vasodilator Agents | 1989 |
8-Bromo cyclic guanosine monophosphate mimics the actions of nitroglycerin on alpha-adrenergic mechanisms in canine saphenous vein.
Topics: Animals; Azepines; Calcium; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Nitroglycerin; Nitroprusside; Phenylephrine; Receptors, Adrenergic, alpha; Saphenous Vein; Vasodilation | 1987 |
Mechanism of glyceryl trinitrate-induced vasodilation. I. Relationship between drug biotransformation, tissue cyclic GMP elevation and relaxation of rabbit aorta.
Topics: Animals; Aorta; Biotransformation; Cyclic GMP; Male; Nitroglycerin; Rabbits; Radioimmunoassay; Time Factors; Vasodilation | 1988 |
Relationship between LTD4-induced endothelium-dependent vasomotor relaxation and cGMP.
Topics: Acetylcholine; Animals; Cyclic GMP; Dogs; Endothelium, Vascular; Isoproterenol; Mesenteric Arteries; Methylene Blue; Nitroglycerin; Norepinephrine; SRS-A; Vasodilation; Vasomotor System | 1988 |
Relaxation of bovine mesenteric artery induced by glyceryl trinitrate is attenuated by pertussis toxin.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Pertussis Toxin; Phenylephrine; Virulence Factors, Bordetella | 1988 |
Endothelium-derived relaxing factor and nitric oxide possess identical pharmacologic properties as relaxants of bovine arterial and venous smooth muscle.
Topics: Acetylcholine; Animals; Biological Assay; Biological Products; Bradykinin; Cattle; Cyclic GMP; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Oxyhemoglobins; Potassium; Superoxide Dismutase; Vasodilation | 1988 |
Studies on vascular smooth muscle tolerance to different cGMP-mediated vasodilators and cross-tolerance to glyceryl trinitrate.
Topics: Acetylcholine; Animals; Calcimycin; Cattle; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Muscle, Smooth, Vascular; Nitroglycerin; Vasodilator Agents | 1988 |
Glyceryl trinitrate inhibits phosphatidylinositol hydrolysis and protein kinase C activity in bovine mesenteric artery.
Topics: Animals; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol Phosphates; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Nitroglycerin; Phenylephrine; Phosphatidylinositols; Phosphorylases; Protein Kinase C | 1988 |
Effects of atrial natriuretic polypeptide and organic nitrates on levels of relaxation and cyclic nucleotide of canine coronary artery with and without endothelial injury.
Topics: Animals; Atrial Natriuretic Factor; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Endothelium, Vascular; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Vasodilation | 1988 |
Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous hemoproteins.
Topics: Acetylcholine; Animals; Aorta; Calcimycin; Cyclic GMP; Cytochrome c Group; Endothelium; Ferric Compounds; Ferrous Compounds; Guanylate Cyclase; Hemeproteins; In Vitro Techniques; Iron; Male; Methemoglobin; Muscle, Smooth, Vascular; Myoglobin; Nitroglycerin; Rabbits; Vasodilation | 1985 |
Stimulation of soluble coronary arterial guanylate cyclase by SIN-1.
Topics: Animals; Cations, Divalent; Cattle; Coronary Vessels; Cyclic GMP; Ferricyanides; Guanylate Cyclase; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Oxadiazoles; Sodium Nitrite; Sulfhydryl Compounds; Sydnones | 1986 |
The relaxant effect of glyceryltrinitrate on isolated human peripheral vein and its relation to cyclic GMP metabolism.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Phenylephrine; Potassium; Serotonin | 1986 |
Development of tolerance to glyceryl trinitrate in an isolated human peripheral vein and its relation to cyclic GMP metabolism.
Topics: Cyclic GMP; Dipyridamole; Drug Tolerance; Guanylate Cyclase; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin | 1986 |
Mode of action of nitrates with regard to vasodilatation and tolerance.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilation | 1986 |
Mechanism of vasodilation by nitrates: role of cyclic GMP.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilator Agents | 1987 |
8-Bromo cyclic GMP mimics the actions of nitroglycerin in modulating responses produced by full and partial alpha-adrenoceptor agonists in canine saphenous vein.
Topics: Adrenergic alpha-Agonists; Animals; Cyclic GMP; Dobutamine; Dogs; In Vitro Techniques; Nitroglycerin; Phenylephrine; Saphenous Vein; Vasoconstriction; Vasodilation | 1988 |
Effect of in vitro organic nitrate tolerance on relaxation, cyclic GMP accumulation, and guanylate cyclase activation by glyceryl trinitrate and the enantiomers of isoidide dinitrate.
Topics: Animals; Aorta; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Guanylate Cyclase; Male; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Rats; Rats, Inbred Strains; Stereoisomerism; Sugar Alcohols; Vasodilation | 1988 |
Desensitization of guanylate cyclase in nitrate tolerance does not impair endothelium-dependent responses.
Topics: Animals; Aorta, Thoracic; Biological Factors; Cattle; Cells, Cultured; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Enzyme Activation; Female; Guanylate Cyclase; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Rabbits; Sulfhydryl Compounds; Vasodilation | 1988 |
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.
Topics: Acetylcholine; Animals; Aorta; Blood Vessels; Calcimycin; Cyclic AMP; Cyclic GMP; Drug Interactions; Endothelium; Hemoglobins; In Vitro Techniques; Isoproterenol; Male; Methylene Blue; Nitroglycerin; Rabbits; Vasodilation | 1985 |
Effects of nitroprusside, glyceryl trinitrate, and 8-bromo cyclic GMP on phosphorylase a formation and myosin light chain phosphorylation in rat aorta.
Topics: Animals; Cyclic GMP; Ferricyanides; Methylene Blue; Muscle, Smooth, Vascular; Myosins; Nitroglycerin; Nitroprusside; Norepinephrine; Phosphorylase a; Phosphorylases; Phosphorylation; Potassium Chloride; Rats | 1985 |
Mechanism of vasodilation by molsidomine.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Sydnones; Vasodilator Agents | 1985 |
Nitroglycerine- and isoprenaline-induced vasodilatation: assessment from the actions of cyclic nucleotides.
Topics: Animals; Bucladesine; Caffeine; Calcium; Cyclic AMP; Cyclic GMP; Drug Interactions; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Nitroglycerin; Norepinephrine; Potassium; Protein Kinases; Rabbits; Swine; Vasodilation | 1985 |
Mechanisms of nitrate-induced vasodilatation and tolerance on a biochemical base.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Cattle; Coronary Circulation; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Isosorbide Dinitrate; Methylene Blue; Nitrates; Nitroglycerin; Nitroprusside; Vasodilation | 1985 |
Dissociation of cysteine and glutathione levels from nitroglycerin-induced relaxation.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Cysteine; Disulfides; Glutathione; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin | 1985 |
Hemodynamic attenuation and the nitrate-free interval: alternative dosing strategies for transdermal nitroglycerin.
Topics: Acetylcysteine; Administration, Oral; Administration, Topical; Angina Pectoris; Angina, Unstable; Animals; Blood Vessels; Cheek; Cyclic GMP; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Endothelium; Exercise Test; Hemodynamics; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Nitroglycerin; Prostaglandins; Vascular Resistance | 1985 |
Effect of glyceryltrinitrate and 8-Br-cGMP on tension and phosphorylase a activity in vascular smooth muscle.
Topics: Animals; Calcium; Cattle; Cyclic AMP; Cyclic GMP; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Phosphorylase a; Phosphorylases | 1985 |
Effects of sulfhydryl reagents on nitroglycerin-induced relaxation of bovine coronary artery.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Ethacrynic Acid; Ethylmaleimide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Sulfhydryl Compounds; Sulfhydryl Reagents | 1986 |
Experimental studies on the mechanism of glyceryl trinitrate-tolerance and dependence.
Topics: Animals; Blood Vessels; Cattle; Cyclic GMP; Drug Tolerance; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Vasodilation | 1986 |
Role of cyclic GMP of canine vascular smooth muscle in relaxation by organic nitrates.
Topics: Animals; Cyclic AMP; Cyclic GMP; Dogs; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitroglycerin; Potassium; Time Factors | 1986 |
Nitroglycerin-induced desensitization of vascular smooth muscle may be mediated through cyclic GMP-disinhibition of phosphatidylinositol hydrolysis.
Topics: Animals; Aorta; Cyclic GMP; Drug Tolerance; Hydrolysis; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Norepinephrine; Phosphatidylinositols; Rats; Rats, Inbred Strains | 1987 |
Studies on the effect of different inhibitors of arachidonic acid metabolism on glyceryltrinitrate-induced relaxation and cGMP elevation in bovine vascular tissue.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Vessels; Cattle; Cyclic GMP; In Vitro Techniques; Masoprocol; Muscle Contraction; Muscle Relaxation; Neuromuscular Depolarizing Agents; Nitroglycerin; Phenylephrine; Quinacrine; Tranylcypromine | 1987 |
Role of cyclic nucleotides in relaxation of fetal lamb ductus arteriosus.
Topics: Alprostadil; Animals; Cyclic AMP; Cyclic GMP; Ductus Arteriosus; Fetus; Isometric Contraction; Muscle, Smooth, Vascular; Nitrogen; Nitroglycerin; Nitroprusside; Sheep | 1987 |
Age-related changes in vascular responsiveness to cyclic nucleotides and contractile agonists.
Topics: Aging; Animals; Aorta, Thoracic; Benzyl Compounds; Bucladesine; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Ethers; Imidazoles; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Nitrites; Nitroglycerin; Norepinephrine; Papaverine; Phosphodiesterase Inhibitors; Potassium Chloride; Rats; Serotonin; Vasoconstrictor Agents | 1974 |
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols.
Topics: Animals; Arteries; Cattle; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Nitroglycerin; Nitroso Compounds; Sodium Nitrite; Sulfhydryl Compounds | 1980 |
Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Male; Nitroglycerin; Protein Kinases; Rats; Rats, Inbred Strains | 1983 |
Effects of cysteine and nitroglycerin on bovine heart guanylate cyclase and on tissue cyclic GMP and lactate of rat atria.
Topics: Animals; Cattle; Cyclic GMP; Cysteine; Guanylate Cyclase; Heart; Lactates; Lactic Acid; Male; Myocardium; Nitroglycerin; Rats; Rats, Inbred Strains | 1983 |
Mechanism of nitrate-induced vasodilation and tolerance.
Topics: Animals; Cattle; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Nitrates; Nitroglycerin; Vasodilation | 1983 |
Nitroglycerin tolerance in vitro: effect on cGMP turnover in vascular smooth muscle.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cattle; Cyclic GMP; Drug Tolerance; Ethanol; Guanylate Cyclase; In Vitro Techniques; Kinetics; Mesenteric Arteries; Muscle Proteins; Muscle, Smooth, Vascular; Nitrites; Nitroglycerin; Time Factors | 1984 |
The effects of nitroglycerin on cyclic nucleotides in the coronary artery in vivo.
Topics: Animals; Coronary Circulation; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin | 1980 |
Dissociation of increases in cyclic GMP from relaxation of arterial smooth muscle.
Topics: Animals; Cyclic GMP; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rats | 1981 |
Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; In Vitro Techniques; Methemoglobin; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Sodium Nitrite; Vasodilator Agents | 1981 |
Correlation between vascular smooth muscle relaxation and increase in cyclic GMP induced by some organic nitro esters.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Ethylene Glycols; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitro Compounds; Nitroglycerin | 1981 |
Vascular tolerance to nitroglycerin and cyclic GMP generation in rat aortic smooth muscle.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Vascular smooth muscle relaxation by nitro compounds: reduced relaxation and cGMP elevation in tolerant vessels and reversal of tolerance by dithiothreitol.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; Dithiothreitol; Drug Tolerance; Ferricyanides; Glutathione; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside | 1982 |
Nitroglycerin tolerance and cyclic GMP generation in the longitudinal smooth muscle of the guinea-pig ileum.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Female; Guinea Pigs; Ileum; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroglycerin; Nitroprusside; Time Factors | 1983 |
Lack of correlation between cyclic GMP elevation and relaxation of nonvascular smooth muscle by nitroglycerin, nitroprusside, hydroxylamine and sodium azide.
Topics: Animals; Azides; Colon; Cyclic GMP; Female; Guinea Pigs; Hydroxylamine; Hydroxylamines; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroglycerin; Nitroprusside; Rats; Sodium Azide; Uterine Contraction; Vas Deferens | 1983 |
Possible role for cyclic GMP in endothelium-dependent relaxation of rabbit aorta by acetylcholine. Comparison with nitroglycerin.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Endothelium; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Rabbits; Time Factors | 1983 |
The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels.
Topics: Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Sydnones; Vasodilator Agents | 1983 |
Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP.
Topics: Animals; Cattle; Cyclic GMP; Female; In Vitro Techniques; Mercaptoethanol; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrogen Oxides; Nitroglycerin; Nitroprusside; Nitroso Compounds; Penicillamine; Pulmonary Artery; Pulmonary Veins; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Vasodilator Agents | 1984 |
Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery.
Topics: Acetylcholine; Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Penicillamine; Pulmonary Artery; Quinacrine; S-Nitroso-N-Acetylpenicillamine | 1984 |
[Effects of nitroglycerin and SIN-1 on spontaneous incidence and cGMP levels in the isolated rat atrium].
Topics: Animals; Cyclic GMP; Heart Atria; Heart Rate; Molsidomine; Nitroglycerin; Oxadiazoles; Rats; Sydnones | 1983 |
Tolerance to nitroglycerin in vascular smooth muscle cells is not affected by the level of intracellular glutathione or L-cysteine.
Topics: Acetylcysteine; Animals; Cyclic GMP; Cysteine; Cytoplasm; Drug Tolerance; Free Radical Scavengers; Glutathione; Muscle, Smooth, Vascular; Nitroglycerin; Sulfhydryl Reagents; Swine; Vasodilator Agents | 1995 |
Inhibition of prostacyclin release from cultured endothelial cells by nitrovasodilator drugs.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Cattle; Cells, Cultured; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Epoprostenol; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1995 |
Effectiveness of an NO-releasing pirsidomine derivative on coronary conductance during long-term administration.
Topics: Animals; Coronary Vessels; Cyclic GMP; Dogs; Female; Hemodynamics; Infusion Pumps; Male; Nitroglycerin; Sydnones; Vasodilation; Vasodilator Agents | 1993 |
Organic nitrates and compounds that increase intraplatelet cyclic guanosine monophosphate (cGMP) levels enhance the antiaggregating effects of the stable prostacyclin analogue iloprost.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adult; Arginine; Blood Platelets; Collagen; Cyclic AMP; Cyclic GMP; Drug Synergism; Endothelium, Vascular; Epinephrine; Humans; Iloprost; Intracellular Fluid; Male; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 4; Second Messenger Systems | 1993 |
Smooth muscle cell responsiveness to nitrovasodilators in hypertensive and normotensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Base Sequence; Blotting, Northern; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; Hypertension; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Oligonucleotide Probes; omega-N-Methylarginine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Vasodilation | 1994 |
Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biosensing Techniques; Bradykinin; Coronary Vessels; Cyclic GMP; Endocardium; Graft Survival; Heart; Heart Transplantation; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Organ Preservation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Transplantation, Heterotopic | 1994 |
Localization and actions of nitric oxide in the cat carotid body.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Axons; Carotid Body; Cats; Cyclic GMP; Electrophysiology; Female; Immunohistochemistry; In Vitro Techniques; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin | 1994 |
Hypoxia modifies the vasodilatory effects of nitroglycerin, prostaglandin E1, and hydralazine on isolated porcine coronary arteries.
Topics: Alprostadil; Analysis of Variance; Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Endothelins; Hydralazine; Hypoxia; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Swine | 1994 |
Contribution of activation of K+ channels to glyceryl trinitrate-induced relaxation of rabbit aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Apamin; Charybdotoxin; Cyclic GMP; Endothelium, Vascular; Ethers, Cyclic; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Okadaic Acid; Peptides; Phosphoprotein Phosphatases; Potassium Channels; Protein Phosphatase 2; Purinones; Rabbits; Scorpion Venoms | 1995 |
Inhibition of vascular nitric oxide-cGMP pathway by plasma from ischemic hindlimb of rats.
Topics: Acetylcholine; Animals; Aorta; Blood Physiological Phenomena; Blood Vessels; Cyclic GMP; Hindlimb; In Vitro Techniques; Ischemia; Methylene Blue; Nitric Oxide; Nitroglycerin; Rats; Rats, Sprague-Dawley; Reference Values | 1995 |
The nitric oxide hypothesis of migraine and other vascular headaches.
Topics: Cyclic GMP; Histamine; Humans; Migraine Disorders; Nitric Oxide; Nitroglycerin; Vascular Headaches | 1995 |
Effects of subarachnoid hemorrhage on vascular responses to calcitonin gene-related peptide and its related second messengers.
Topics: Analysis of Variance; Animals; Basilar Artery; Calcitonin Gene-Related Peptide; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Ischemic Attack, Transient; Isometric Contraction; Male; Nitroglycerin; Potassium; Rabbits; Serotonin; Subarachnoid Hemorrhage; Vasodilation | 1995 |
Impaired coronary dilator responses to substance P and impaired flow-dependent dilator responses in heart transplant patients with graft vasculopathy.
Topics: Adult; Analysis of Variance; Blood Flow Velocity; Blood Platelets; Cardiac Catheterization; Coronary Angiography; Coronary Circulation; Coronary Vessels; Cyclic GMP; Endothelium, Vascular; Female; Graft Occlusion, Vascular; Heart Transplantation; Humans; Male; Middle Aged; Muscle, Smooth, Vascular; Nitroglycerin; Papaverine; Substance P; Vasodilation | 1993 |
Antiplatelet effects of nitroglycerin in healthy subjects and in patients with stable angina pectoris.
Topics: Adenosine Diphosphate; Adult; Aged; Angina Pectoris; Blood Platelets; Cyclic GMP; Female; Humans; In Vitro Techniques; Male; Middle Aged; Nitroglycerin; Platelet Aggregation Inhibitors | 1993 |
Dissociation of hemodynamic and coronary arterial tolerance to nitroglycerin in dogs.
Topics: Animals; Blood Pressure; Coronary Vessels; Cyclic GMP; Dogs; Drug Tolerance; Female; Hemodynamics; In Vitro Techniques; Infusions, Intravenous; Isometric Contraction; Male; Muscle Relaxation; Nitroglycerin; Radioimmunoassay | 1993 |
Nitric oxide liberating, soluble guanylate cyclase stimulating and vasorelaxing properties of the new nitrate-compound SPM 3672.
Topics: Animals; Aorta, Thoracic; Coronary Vessels; Cyclic GMP; Cysteine; Guanylate Cyclase; Humans; Male; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitroglycerin; Rats; Rats, Wistar; Solubility; Swine; Vasodilator Agents | 1993 |
Contribution of cyclic GMP generation to the relaxation by nipradilol in the rabbit aorta.
Topics: Adrenergic beta-Antagonists; Animals; Aorta; Cyclic GMP; In Vitro Techniques; Male; Nitroglycerin; Propanolamines; Rabbits; Vasodilation; Vasodilator Agents | 1995 |
Dissociation of tissue thiols content from nitroglycerin-induced cyclic-3',5'-guanosine monophosphate and the state of tolerance: in vivo experiments in rats.
Topics: Animals; Aorta; Cyclic GMP; Cysteine; Drug Tolerance; Glutathione; Nitroglycerin; Rats; Rats, Sprague-Dawley; Vena Cava, Inferior | 1995 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents | 1995 |
Role of nitric oxide on vasorelaxation in human umbilical artery.
Topics: Caffeine; Calcimycin; Calcium; Cyclic GMP; Female; Histamine; Humans; In Vitro Techniques; Nitric Oxide; Nitroglycerin; Pregnancy; Umbilical Arteries; Vasodilation | 1995 |
[Hemodynamic and neurohumoral effects of carperitide (alpha-human atrial natriuretic peptide) in dogs with low-output heart failure].
Topics: Acute Disease; Animals; Atrial Natriuretic Factor; Cardiac Output, Low; Cyclic GMP; Diuresis; Dogs; Female; Hemodynamics; Male; Methoxamine; Nitroglycerin; Peptide Fragments; Renin-Angiotensin System | 1995 |
Potentiation of endogenous nitric oxide with superoxide dismutase inhibits platelet-mediated thrombosis in injured and stenotic arteries.
Topics: Animals; Arteries; Aspirin; Blood Platelets; Cardiovascular Agents; Constriction, Pathologic; Cyclic GMP; Drug Evaluation, Preclinical; Drug Synergism; Nitric Oxide; Nitroglycerin; Organometallic Compounds; Rabbits; Random Allocation; Superoxide Dismutase; Thrombosis; Time Factors | 1995 |
Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase.
Topics: Animals; Aorta; Cyclic GMP; Glutathione Transferase; Isoenzymes; Models, Biological; Nitroglycerin; Rabbits; Stilbenes; Vasodilation | 1994 |
Parallel tolerance between platelet cyclic GMP and preload effects of nitroglycerin in anaesthetized mini-pigs.
Topics: Anesthesia; Animals; Blood Platelets; Cyclic GMP; Drug Tolerance; Elasticity; Injections, Intravenous; Male; Muscle, Smooth, Vascular; Nitroglycerin; Swine; Swine, Miniature; Ventricular Function, Left | 1994 |
Inhibition of nitric oxide-dependent vasodilation by halogenated anesthetics.
Topics: Anesthetics; Animals; Carbon Monoxide; Cyclic GMP; Dogs; Endothelium, Vascular; Guanylate Cyclase; Halothane; In Vitro Techniques; Isoflurane; Nitric Oxide; Nitroglycerin; Rabbits; Rats; Vasodilation | 1994 |
Effects of forskolin and organic nitrate on aggregation and intracellular cyclic nucleotide content in human platelets.
Topics: Adult; Blood Platelets; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors | 1994 |
Effects of interleukin-1 beta and nitric oxide on cardiac myocytes.
Topics: Animals; Atrial Natriuretic Factor; Brain-Derived Neurotrophic Factor; Bucladesine; Cells, Cultured; Cyclic GMP; Heart; Interleukin-1; Myocardium; Nerve Tissue Proteins; Nitric Oxide; Nitroglycerin; Phenylephrine; Proteins; Rats; RNA, Messenger; Transcription Factor AP-1 | 1995 |
Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit.
Topics: Aminoquinolines; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Drug Interactions; Enzyme Activation; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Rabbits; Rats; Rats, Wistar; Vasodilator Agents | 1994 |
Vasorelaxant mechanism of the new vasodilator, FK409.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arginine; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitro Compounds; Nitroglycerin; omega-N-Methylarginine; Oxyhemoglobins; Rabbits; Rats; Rats, Sprague-Dawley; Solubility; Vasodilator Agents | 1993 |
Pulmonary vascular smooth muscle relaxation by cGMP- versus cAMP-mediated mechanisms.
Topics: Alprostadil; Amrinone; Analysis of Variance; Animals; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Phosphodiesterase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Prostaglandin E; Vasodilation; Vasodilator Agents | 1994 |
Exogenous nitric oxide inhibits proliferation of cultured vascular endothelial cells.
Topics: Animals; Cattle; Cell Division; Cells, Cultured; Cyclic GMP; DNA; Embryo, Mammalian; Endothelium, Vascular; Guanylate Cyclase; Methylene Blue; Nitric Oxide; Nitroglycerin; Nitroprusside; Thymidine | 1994 |
Effects of maturation on cyclic GMP-dependent vasodilation in ovine basilar and carotid arteries.
Topics: Animals; Animals, Newborn; Basilar Artery; Biotransformation; Carotid Artery, Common; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Nitroglycerin; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sheep; Vasodilation; Vasodilator Agents | 1994 |
Loss of preconditioning in rabbits with vascular tolerance to nitroglycerin.
Topics: Animals; Blood Pressure; Cardiac Pacing, Artificial; Cyclic GMP; Drug Tolerance; Male; Myocardial Ischemia; Nitroglycerin; Rabbits | 1994 |
Functional analysis of vascular dysfunction in cyclosporin treated rats.
Topics: Acetylcholine; Animals; Aorta; Arginine; Cyclic GMP; Cyclosporins; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Rats; Rats, Wistar | 1994 |
Inhibition of the biotransformation and pharmacological actions of glyceryl trinitrate by the flavoprotein inhibitor, diphenyleneiodonium sulfate.
Topics: Animals; Aorta; Biotransformation; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Male; NADPH-Ferrihemoprotein Reductase; Nitroglycerin; Onium Compounds; Oxazines; Rats; Rats, Sprague-Dawley; Vasodilation | 1994 |
Rp-8-Br-guanosine-3',5'-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rabbits; Rats; Thionucleotides | 1994 |
Contribution of nitric oxide to the endothelium-dependent hyperpolarization in rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Carbachol; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; omega-N-Methylarginine; Rats; Rats, Wistar | 1994 |
Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus.
Topics: Aminoquinolines; Animals; Cyclic GMP; Cysteine; Drug Tolerance; Electric Stimulation; Female; Gastric Fundus; Glutathione; In Vitro Techniques; Male; Nitric Oxide; Nitroglycerin; Nitroso Compounds; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; S-Nitrosothiols | 1994 |
Plasma arteriovenous cGMP difference as a useful indicator of nitrate tolerance in patients with heart failure.
Topics: Atrial Natriuretic Factor; Captopril; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Female; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Nitroglycerin; Pulmonary Wedge Pressure | 1994 |
Methylene blue inhibits the antithrombotic effect of nitroglycerin.
Topics: Animals; Antifibrinolytic Agents; Aorta; Cyclic GMP; Drug Evaluation, Preclinical; Fibrinolytic Agents; Guanylate Cyclase; Indium Radioisotopes; Infusions, Intravenous; Methylene Blue; Nitroglycerin; Platelet Aggregation; Swine; Thrombosis | 1993 |
Effect of inhibitors of glutathione S-transferase on glyceryl trinitrate activity in isolated rat aorta.
Topics: Animals; Aorta; Biotransformation; Cyclic GMP; Enzyme Activation; Glutathione Transferase; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1993 |
Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Cyclic GMP; Femoral Artery; Glyburide; In Vitro Techniques; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1994 |
Nitroglycerin (exogenous nitric oxide) substitutes for endothelium-derived nitric oxide in potentiating vasorelaxations and cyclic AMP elevations induced by calcitonin gene-related peptide (CGRP) in rat aorta.
Topics: Animals; Aorta; Calcitonin Gene-Related Peptide; Cyclic AMP; Cyclic GMP; Drug Synergism; Endothelium, Vascular; Male; Nitric Oxide; Nitroglycerin; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilation | 1994 |
Tolerance to nitroglycerin in vascular smooth muscle cells: recovery and cross-tolerance to sodium nitroprusside.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Swine | 1994 |
Reversal of nitroglycerin tolerance in vitro by the cGMP-phosphodiesterase inhibitor zaprinast.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Hydrolysis; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitroglycerin; Purinones; Rats; Rats, Sprague-Dawley | 1993 |
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Cyclic GMP; Endothelium, Vascular; Humans; In Vitro Techniques; Male; Metyrapone; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Proadifen; Rabbits; Sulfobromophthalein | 1993 |
Endothelin-mediated cardiorenal hemodynamic and neuroendocrine effects are attenuated by nitroglycerin in vivo.
Topics: Animals; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Endothelins; Epoprostenol; Heart; Hemodynamics; Kidney; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Vasoconstriction; Vasodilation | 1993 |
Effects of physostigmine and some nitric oxide-cyclic GMP-related compounds on muscarinic receptor-mediated autoinhibition of hippocampal acetylcholine release.
Topics: Acetylcholine; Animals; Arginine; Atropine; Bucladesine; Cyclic GMP; Dibutyryl Cyclic GMP; Electric Stimulation; Hippocampus; In Vitro Techniques; Kinetics; Male; Nitric Oxide; Nitroarginine; Nitroglycerin; Nitroprusside; Physostigmine; Rats; Rats, Wistar; Receptors, Muscarinic | 1993 |
Nitric oxide promotes DNA synthesis and cyclic GMP formation in endothelial cells from postcapillary venules.
Topics: Animals; Arginine; Cattle; Cells, Cultured; Coronary Vessels; Cyclic GMP; DNA; DNA Replication; Endothelium, Vascular; Fibroblast Growth Factor 2; Isosorbide Dinitrate; Kinetics; Nitric Oxide; Nitroglycerin; Nitroprusside; omega-N-Methylarginine; Thymidine; Venules | 1993 |
Platelet cyclic GMP. A potentially useful indicator to evaluate the effects of nitroglycerin and nitrate tolerance.
Topics: Atrial Natriuretic Factor; Blood Platelets; Coronary Angiography; Coronary Vessels; Cyclic GMP; Drug Tolerance; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Vasodilation | 1993 |
Solving the mystery of nitrate tolerance. A new scent on the trail?
Topics: Blood Platelets; Coronary Vessels; Cyclic GMP; Drug Tolerance; Humans; Isosorbide Dinitrate; Nitroglycerin; Vasodilation | 1993 |
Relationship between myoglobin contents and increases in cyclic GMP produced by glyceryl trinitrate and nitric oxide in rabbit aorta, right atrium and papillary muscle.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Atrial Function, Right; Cyclic GMP; Kinetics; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Myoglobin; Nitric Oxide; Nitroglycerin; Papillary Muscles; Purinones; Rabbits | 1993 |
Effect of ethacrynic acid, a glutathione-S-transferase inhibitor, on nitroglycerin-mediated cGMP elevation and vasorelaxation of rabbit aortic strips.
Topics: Animals; Aorta; Cyclic GMP; Ethacrynic Acid; Glutathione Transferase; In Vitro Techniques; Muscle Relaxation; Nitroglycerin; Nitroprusside; Rabbits; Tritium; Vasodilator Agents | 1993 |
Interactions of nitrovasodilators and atrial natriuretic peptide in isolated dog coronary arteries.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Coronary Vessels; Cyclic GMP; Dinoprost; Dogs; Epoprostenol; Female; In Vitro Techniques; Isometric Contraction; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Papaverine; Platelet Aggregation Inhibitors; Vasodilator Agents | 1993 |
The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro.
Topics: Cell Migration Inhibition; Chemotaxis, Leukocyte; Cyclic GMP; Humans; Isosorbide Dinitrate; Molsidomine; Monocytes; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1993 |
Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin.
Topics: Animals; Arteries; Captopril; Coronary Vessels; Cyclic GMP; Dogs; Drug Interactions; Drug Tolerance; Female; In Vitro Techniques; Male; Nitric Oxide; Nitroglycerin; Nitroprusside; Vasodilator Agents | 1995 |
Relation between cyclic GMP generation and cerebrovascular reactivity: modulation by NPY and alpha-trinositol.
Topics: Acetylcholine; Animals; Basilar Artery; Brain; Cerebral Arteries; Cerebral Veins; Cyclic GMP; Drug Interactions; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Neuropeptide Y; Nitroglycerin; Nitroprusside; Platelet Aggregation Inhibitors; Radioimmunoassay; Substance P; Vasodilator Agents | 1995 |
Human endothelial cells bioactivate organic nitrates to nitric oxide: implications for the reinforcement of endothelial defence mechanisms.
Topics: Biotransformation; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Humans; Isosorbide Dinitrate; Nitrates; Nitric Oxide; Nitroglycerin; Platelet Aggregation; Time Factors | 1995 |
Low increase in cGMP induced by organic nitrates and nitrovasodilators improves contractile response of rat ventricular myocytes.
Topics: Animals; Cells, Cultured; Cyclic GMP; Electric Stimulation; Heart Ventricles; Hydrazines; Isosorbide Dinitrate; Male; Myocardial Contraction; Nitrogen Oxides; Nitroglycerin; Penicillamine; Pentaerythritol Tetranitrate; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1996 |
Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Guanylate Cyclase; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Pulmonary Artery; Quinoxalines; S-Nitrosoglutathione; Swine; Vasodilation | 1996 |
Cardiovascular interactions characterizing the vasodilator components of nicorandil in conscious dogs.
Topics: Animals; Blood Pressure; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Heart Rate; Male; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Vasodilator Agents | 1995 |
Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state.
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Platelets; Blood Pressure; Calcium; Cyclic GMP; Dogs; Drug Interactions; Drug Synergism; Drug Tolerance; Female; Infusions, Intravenous; Male; Muscle, Smooth, Vascular; Nitroglycerin; Thrombin; Up-Regulation; Vasodilator Agents; Ventricular Function, Left | 1996 |
Effect of selective inhibition of potassium channels on vasorelaxing response to cromakalim, nitroglycerin and nitric oxide of canine coronary arteries.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; In Vitro Techniques; Male; Nitric Oxide; Nitroglycerin; Peptides; Potassium Channel Blockers; Potassium Chloride; Pyrroles; Vasodilation; Vasodilator Agents | 1995 |
Insulin exerts opposite effects on platelet function at physiological and supraphysiological concentrations.
Topics: Adenosine Diphosphate; Adult; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Insulin; Male; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinones; Theophylline; Vasodilator Agents | 1996 |
Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases.
Topics: Animals; Aorta; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Glutathione Transferase; Isoenzymes; Male; Nitroglycerin; Rabbits | 1996 |
In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance.
Topics: Animals; Aorta; Cyclic GMP; Drug Tolerance; Ethylmaleimide; Glutathione Transferase; Male; Nitric Oxide; Nitroglycerin; Nitroprusside; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sulfhydryl Compounds; Sulfhydryl Reagents; Vasodilator Agents | 1996 |
Mechanism of ITF 296-induced vasorelaxation compared to nitroglycerin and isosorbide dinitrate: relationship between relaxation of rabbit aorta and tissue cGMP.
Topics: Animals; Aorta, Thoracic; Benzoxazines; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitroglycerin; Oxazines; Rabbits; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Effects of nitroglycerin on vasospasm and cyclic nucleotides in a primate model of subarachnoid hemorrhage.
Topics: Animals; Blood Pressure; Cerebral Angiography; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Cyclic GMP; Heart Rate; Ischemic Attack, Transient; Macaca; Macaca fascicularis; Nervous System; Nitroglycerin; Nucleotides, Cyclic; Regional Blood Flow; Subarachnoid Hemorrhage; Vasodilator Agents | 1996 |
Selective effect of high arterial pressure in hypertension upon inhibition of cGMP versus cAMP mediated vascular relaxation.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Blood Pressure; Bucladesine; Cyclic AMP; Cyclic GMP; Hypertension, Renovascular; In Vitro Techniques; Isoproterenol; Nitric Oxide; Nitroglycerin; Rats; Rats, Sprague-Dawley; Vasodilation | 1996 |
Studies of vascular tolerance to nitroglycerin: effects of N-acetylcysteine, NG-monomethyl L-arginine, and endothelin-1.
Topics: Acetylcysteine; Animals; Aorta; Cyclic GMP; Drug Tolerance; Endothelin-1; Enzyme Inhibitors; Free Radical Scavengers; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroglycerin; omega-N-Methylarginine; Rats; Vasodilator Agents | 1996 |
Sustained antiplatelet properties of nitroglycerin during hemodynamic tolerance in rats.
Topics: Animals; Blood Platelets; Cyclic GMP; Drug Tolerance; Hematocrit; Hemodynamics; Male; Nitroglycerin; Platelet Aggregation Inhibitors; Platelet Count; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1996 |
Relative importance of prostaglandin/cyclic adenosine monophosphate and nitric oxide/cyclic guanosine monophosphate pathways in lung preservation.
Topics: Animals; Cryopreservation; Cyclic AMP; Cyclic GMP; Drug Evaluation, Preclinical; Epoprostenol; Graft Survival; Hypertonic Solutions; Lung Transplantation; Male; Nitric Oxide; Nitroglycerin; Organ Preservation; Prostaglandins; Rats; Rats, Sprague-Dawley; Reperfusion | 1996 |
Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivo.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Analysis of Variance; Animals; Aorta, Abdominal; Blood Pressure; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Drug Tolerance; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Purinones; Rats; Rats, Inbred SHR; Vasodilator Agents | 1996 |
Diaspirin cross-linked hemoglobin does not alter isolated human umbilical artery or vein tone.
Topics: Acetylcholine; Animals; Aspirin; Cyclic GMP; Dose-Response Relationship, Drug; Hemoglobins; Humans; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Serotonin; Substance P; Swine; Umbilical Arteries; Umbilical Veins; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Inhibition of the pharmacological actions of glyceryl trinitrate after the electroporetic delivery of a glutathione S-transferase inhibitor.
Topics: Animals; Biotransformation; Cells, Cultured; Cyclic GMP; Electroporation; Enzyme Inhibitors; Glutathione Transferase; Nitroglycerin; Swine | 1996 |
Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures.
Topics: Animals; Aplysia; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Cysteine; Ethylmaleimide; Fetus; Hippocampus; Hydrazines; Kinetics; Neuroglia; Neurons; Nitric Oxide; Nitrogen Oxides; Nitroglycerin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Synapses; Synaptic Transmission | 1996 |
Response of cultured cerebral artery smooth muscle cells to the nitric oxide vasodilators, nitroglycerin and sodium nitroprusside.
Topics: Animals; Cells, Cultured; Cerebral Arteries; Cyclic GMP; Dose-Response Relationship, Drug; Female; Guanylate Cyclase; Kinetics; Male; Muscle, Smooth, Vascular; Nitroglycerin; Nitroprusside; Swine; Time Factors; Vasodilator Agents | 1997 |
Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation.
Topics: Animals; Aorta; COS Cells; Cyclic GMP; Guanosine Triphosphate; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Oxidation-Reduction; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
Persistent inhibition of platelets during continuous nitroglycerin therapy despite hemodynamic tolerance.
Topics: Administration, Cutaneous; Analysis of Variance; Animals; Aorta; Blood Platelets; Blood Pressure; Cyclic GMP; Drug Tolerance; Hemodynamics; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Swine; Time Factors; Tunica Media; Vasodilator Agents | 1997 |
Myosin light chain kinase phosphorylation in nitrovasodilator induced swine carotid artery relaxation.
Topics: Aequorin; Animals; Calcium; Carotid Arteries; Cyclic AMP; Cyclic GMP; Histamine; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Nitroglycerin; Nitroprusside; Peptide Mapping; Phosphorylation; Swine; Vasodilator Agents | 1997 |
Supersensitive dilator response to nitroglycerin but not to atrial natriuretic peptide in spastic coronary arteries in coronary spastic angina.
Topics: Adult; Aged; Angina Pectoris; Atrial Natriuretic Factor; Biological Availability; Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Cyclic GMP; Diltiazem; Female; Guanylate Cyclase; Humans; Injections, Intra-Arterial; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Vasodilator Agents | 1997 |
Downregulation of nitric oxide synthase activity in human platelets by nitroglycerin and authentic nitric oxide.
Topics: Blood Platelets; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Platelet Aggregation | 1997 |
The effect of continuous versus intermittent treatment with transdermal nitroglycerin on pacing-induced preconditioning in conscious rabbits.
Topics: Administration, Cutaneous; Animals; Cardiac Pacing, Artificial; Cyclic AMP; Cyclic GMP; Ischemic Preconditioning, Myocardial; Male; Nitroglycerin; Rabbits; Vasodilator Agents | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Effects of cAMP and cGMP on L-type calcium channel currents in rat mesenteric artery cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bucladesine; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Patch-Clamp Techniques; Rats; Rats, Wistar | 1997 |
Effects of enalapril during continuous nitrate therapy: analysis of diameter of coronary arteries and platelet cyclic guanosine monophosphate.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Platelets; Case-Control Studies; Coronary Angiography; Coronary Disease; Coronary Vessels; Cyclic GMP; Drug Administration Schedule; Enalapril; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Norepinephrine; Renin; Vasodilator Agents | 1997 |
Activation of guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase in rabbit aorta by nitroglycerin and sodium nitroprusside.
Topics: Animals; Aorta; Blotting, Western; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Female; Male; Nitroglycerin; Nitroprusside; Phosphorylation; Rabbits; Vasoconstriction; Vasodilator Agents | 1997 |
Platelet function is inhibited by nitric oxide liberation during nitroglycerin-induced hypotension anaesthesia.
Topics: Adult; Aged; Anesthesia, General; Bleeding Time; Blood Platelets; Calcium; Cyclic GMP; Female; Humans; Hypotension, Controlled; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1997 |
No cross-tolerance between S-nitrosocaptopril and nitroglycerin in dog coronary arteries in vivo.
Topics: Aldosterone; Animals; Captopril; Coronary Circulation; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Female; Hemodynamics; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Nitrates; Nitric Oxide; Nitroglycerin; Norepinephrine; Peptidyl-Dipeptidase A; Renin; Vasodilator Agents | 1998 |
Nitric oxide inhibits vascular bioactivation of glyceryl trinitrate: a novel mechanism to explain preferential venodilation of organic nitrates.
Topics: Animals; Blood Platelets; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Guanylate Cyclase; Hemodynamics; Humans; In Vitro Techniques; Nitric Oxide; Nitroglycerin; Nitroprusside; Swine; Vasodilation; Vasodilator Agents | 1998 |
Exercise reduces epicardial coronary artery wall stiffness: roles of cGMP and cAMP.
Topics: Acetylcholine; Adenosine; Analysis of Variance; Animals; Blood Pressure; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Elasticity; Nitroglycerin; Physical Conditioning, Animal; Regression Analysis; Vasodilator Agents | 1998 |
Diverse relaxation responses of canine large and small conductive coronary arteries to glyceryl trinitrate and nitric oxide on the one hand and to 8-bromoguanosine 3':5' cyclic monophosphate on the other.
Topics: Acetylcysteine; Animals; Biotransformation; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cysteine; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Female; Free Radical Scavengers; Guanylate Cyclase; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Vasodilation; Vasodilator Agents | 1998 |
Impaired vasorelaxant responses to natriuretic peptides in the stroke-prone phenotype of spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Carotid Artery, Internal; Cerebrovascular Disorders; Cyclic GMP; Hypertension; In Vitro Techniques; Male; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Nitroglycerin; Phenotype; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1998 |
Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM.
Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Blood Glucose; Blood Platelets; Blood Pressure; Body Mass Index; Cholesterol; Cholesterol, HDL; Cyclic GMP; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Male; Nitroglycerin; Obesity; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thinness; Triglycerides | 1998 |
Halothane attenuates nitric oxide relaxation of rat aortas by competition for the nitric oxide receptor site on soluble guanylyl cyclase.
Topics: Aminoquinolines; Anesthetics, Inhalation; Animals; Aorta, Thoracic; Binding, Competitive; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Halothane; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Vitamin C attenuates nitrate tolerance independently of its antioxidant effect.
Topics: Animals; Antioxidants; Ascorbic Acid; Cyclic GMP; Drug Resistance; LLC-PK1 Cells; Nitrates; Nitrogen Oxides; Nitroglycerin; Spermine; Swine | 1998 |
Cardiovascular activity of WIN 65579, a novel inhibitor of cyclic GMP phosphodiesterase 5.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Blood Pressure; Cyclic GMP; Heart Rate; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Phosphodiesterase Inhibitors; Purinones; Pyrimidines; Rats; Rats, Inbred SHR | 1998 |
Liposomal VIP attenuates phenylephrine- and ANG II-induced vasoconstriction in vivo.
Topics: Acetylcholine; Angiotensin II; Animals; Arterioles; Calcimycin; Cheek; Cricetinae; Cyclic GMP; Drug Carriers; Indomethacin; Isoproterenol; Liposomes; Male; Mesocricetus; Mouth Mucosa; Nitroglycerin; Phenylephrine; Protein Structure, Secondary; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilator Agents | 1998 |
Formation of reactive oxygen species by pentaerithrityltetranitrate and glyceryl trinitrate in vitro and development of nitrate tolerance.
Topics: Animals; Blood Platelets; Cells, Cultured; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Hydroxyl Radical; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Reactive Oxygen Species; Spin Trapping; Superoxides; Swine | 1998 |
Cross tolerance between nitroglycerin and neural relaxation of the rabbit sphincter of Oddi.
Topics: Animals; Cyclic AMP; Cyclic GMP; Drug Tolerance; Electric Stimulation; In Vitro Techniques; Male; Muscle, Smooth; Nitroglycerin; Rabbits; Sincalide; Sphincter of Oddi | 1998 |
Efficacy and rebound phenomenon related to intermittent nitroglycerin therapy for the prevention of nitrate tolerance.
Topics: Administration, Cutaneous; Adult; Cyclic GMP; Drug Tolerance; Female; Forearm; Humans; Male; Middle Aged; Nitrates; Nitroglycerin; Vasodilation; Vasodilator Agents | 1998 |
Antioxidants and nitrate tolerance.
Topics: Antioxidants; Cyclic GMP; Drug Tolerance; Humans; Nitroglycerin; Vitamin E | 1998 |
Lack of correlation between myocardial nitric oxide and cyclic guanosine monophosphate content in both nitrate-tolerant and -nontolerant rats.
Topics: Animals; Biotransformation; Cyclic GMP; Drug Tolerance; Male; Myocardium; Nitric Oxide; Nitroglycerin; Rats; Rats, Wistar | 1998 |
[Effect of nitric oxide on rabbit baroreceptor activity].
Topics: Animals; Arginine; Carotid Sinus; Cyclic GMP; Female; In Vitro Techniques; Male; Nitric Oxide; Nitroglycerin; Pressoreceptors; Rabbits; Vasodilator Agents | 1997 |
Nitrate tolerance is specific for nitric acid esters and its recovery requires an intact protein synthesis.
Topics: Animals; Cell Line; Cyclic GMP; Cycloheximide; Kinetics; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroglycerin; Nitroprusside; Protein Biosynthesis; Spermine; Vasodilator Agents | 1998 |
Effects of guanylyl cyclase and protein kinase G inhibitors on vasodilatation in non-tolerant and tolerant bovine coronary arteries.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Interactions; Drug Tolerance; Enzyme Inhibitors; Guanylate Cyclase; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Penicillamine; Protein Kinase Inhibitors; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Thionucleotides; Vasodilation; Vasodilator Agents | 1999 |
Determinants of the response of human blood vessels to nitric oxide donors in vivo.
Topics: Adult; Bradykinin; Cyclic GMP; Dipyridamole; Forearm; Hand; Humans; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; omega-N-Methylarginine; Radial Artery; Vascular Resistance; Vasodilation; Veins | 1999 |
The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Guanylate Cyclase; LLC-PK1 Cells; Molsidomine; Mutagens; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroglycerin; Nitroprusside; Spermine; Swine; Vasodilator Agents | 1999 |
Possible involvement of nitroglycerin converting step in nitroglycerin tolerance.
Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Lipopolysaccharides; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroglycerin; Nitroprusside; Rats; Rats, Wistar; Vasodilation | 1999 |
Glutathione reverses endothelial dysfunction and improves nitric oxide bioavailability.
Topics: Acetylcholine; Arteriosclerosis; Blood Flow Velocity; Cyclic GMP; Endothelium, Vascular; Female; Femoral Artery; Glutathione; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Vascular Resistance; Vasodilation; Vasodilator Agents | 1999 |
Reduced nitric oxide production by L-arginine deficiency in lysinuric protein intolerance exacerbates intravascular coagulation.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Antithrombin III; Arginine; Blood Coagulation Disorders; Citrulline; Cyclic GMP; Humans; Lysine; Male; Nitric Oxide; Nitroglycerin; Ornithine; Peptide Hydrolases; Platelet Aggregation; Thrombosis | 1999 |
Tolerance to nitrates with enhanced radical formation suppressed by carvedilol.
Topics: Adrenergic beta-Antagonists; Animals; Antioxidants; Ascorbic Acid; Blood Platelets; Calcium; Carbazoles; Carvedilol; Cyclic GMP; Dogs; Female; Male; Nitroglycerin; Nitroprusside; Platelet Aggregation; Propanolamines; Reactive Oxygen Species; Vasodilator Agents | 1999 |
Thiopental inhibits nitric oxide production in rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Barbiturates; Calcimycin; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Guanylate Cyclase; Histamine; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Rats; Rats, Wistar; Thiopental | 1999 |
Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury.
Topics: Animals; Cyclic GMP; DNA Damage; Immunoenzyme Techniques; Lung; Lung Transplantation; Male; Nitroglycerin; Organ Preservation; Oxidative Stress; Peroxidase; Pulmonary Alveoli; Pulmonary Edema; Rats; Rats, Inbred Lew; Reperfusion Injury; Vasodilator Agents | 2000 |
cGMP-mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery.
Topics: Actins; Actomyosin; Animals; Carotid Arteries; Centrifugation; Crystallins; Cyclic GMP; Heat-Shock Proteins; Histamine; HSP20 Heat-Shock Proteins; In Vitro Techniques; Molecular Sequence Data; Muscle, Smooth, Vascular; Myosin Light Chains; Nitroglycerin; Oxygen Consumption; Phosphoproteins; Phosphorylation; Sequence Homology, Amino Acid; Swine; Troponin I; Vasodilation; Vasodilator Agents | 2000 |
Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators.
Topics: Administration, Inhalation; Colectomy; Cyclic GMP; Dipyridamole; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Middle Aged; Nitric Oxide; Nitroglycerin; Vasodilator Agents | 2000 |
A common pathway for nitric oxide release from NO-aspirin and glyceryl trinitrate.
Topics: Animals; Aspirin; Cell Line; Cyclic GMP; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Epithelial Cells; Free Radical Scavengers; Imidazoles; Kidney; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Protein Binding; Swine | 2000 |
Activation of ATP-sensitive K(+) channels: mechanism of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside.
Topics: Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apamin; Charybdotoxin; Cyclic GMP; Dinoprostone; Dose-Response Relationship, Drug; Male; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2000 |
Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells.
Topics: Calcium; Cell Division; Cell Movement; Cells, Cultured; Chemotaxis; Cyclic GMP; Dinoprostone; Guanylate Cyclase; Hemostatics; Humans; Liver; Nitric Oxide Donors; Nitroglycerin; Penicillamine; Platelet-Derived Growth Factor; Signal Transduction; Thrombin; Type C Phospholipases; Vasodilator Agents | 2000 |
Antiplatelet activity of Staphylococcus aureus lipoteichoic acid is mediated through a cyclic AMP pathway.
Topics: Alprostadil; Blood Platelets; Blood Proteins; Calcium Signaling; Collagen; Cyclic AMP; Cyclic GMP; Cytokines; Enzyme Induction; Gram-Positive Bacteria; Humans; Lipopolysaccharides; Molecular Weight; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroglycerin; Phorbol 12,13-Dibutyrate; Phosphorylation; Platelet Aggregation Inhibitors; Protein Kinase C; Protein Processing, Post-Translational; Second Messenger Systems; Shock, Septic; Staphylococcus aureus; Teichoic Acids | 2000 |
Endothelin receptor antagonism does not prevent the development of in vivo glyceryl trinitrate tolerance in the rat.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Biotransformation; Blood Pressure; Cyclic GMP; Drug Tolerance; Endothelin Receptor Antagonists; Endothelin-1; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitroglycerin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sulfonamides; Vasodilator Agents | 2000 |
Inhibition of human platelet aggregation by nitric oxide donor drugs: relative contribution of cGMP-independent mechanisms.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Collagen; Cyclic GMP; Enzyme Inhibitors; Glucosamine; Glutathione; Humans; In Vitro Techniques; Kinetics; Models, Biological; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Nitroso Compounds; Oxadiazoles; Penicillamine; Platelet Aggregation; Platelet Aggregation Inhibitors; Quaternary Ammonium Compounds; Quinoxalines; S-Nitrosoglutathione | 2000 |
Enhancement of nitroglycerin induced blood vessel relaxation in chronic renal failure model rats.
Topics: Adenine; Animals; Aorta; Aryl Hydrocarbon Hydroxylases; Blood Urea Nitrogen; Cyclic GMP; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Disease Models, Animal; Glutathione Transferase; Kidney Failure, Chronic; Male; Nephrectomy; Nitroglycerin; Nitroprusside; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Vasodilation | 1999 |
Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Homeostasis; Humans; Mammary Arteries; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen Oxides; Nitroglycerin; omega-N-Methylarginine; Phenylephrine; Solubility; Spermine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenoviruses, Human; Animals; beta-Galactosidase; Cyclic GMP; Drug Synergism; Endothelial Growth Factors; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Guanylate Cyclase; Heart; Humans; Isoquinolines; Lymphokines; Myocardium; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Piperazines; Purines; Purinones; Pyridines; Rabbits; Sildenafil Citrate; Sulfones; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Enzyme Activators; In Vitro Techniques; Indazoles; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rabbits; Vasodilator Agents | 2001 |
Effects of the superoxide dismutase-mimic compound TEMPOL on oxidant stress-mediated endothelial dysfunction.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Cyclic N-Oxides; Endothelium, Vascular; Free Radicals; In Vitro Techniques; Male; Molecular Mimicry; Nitroglycerin; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxide Dismutase; Vasoconstriction; Vasodilation; Vasodilator Agents | 1999 |
Two possible mechanisms underlying nitrate tolerance in monkey coronary arteries.
Topics: Animals; Atrial Natriuretic Factor; Coronary Vessels; Cyclic GMP; Drug Interactions; Drug Tolerance; Female; Macaca; Male; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Vasodilation; Vasodilator Agents | 2001 |
Effects of nitric oxide donors on the contractility and prostaglandin synthesis of myometrial strips from pregnant and non-pregnant women.
Topics: Cyclic GMP; Dinoprost; Dinoprostone; Epoprostenol; Female; Humans; Myometrium; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Pregnancy; Prostaglandins; Uterine Contraction | 2001 |
The role of nitric oxide in the mechanism of penile erection.
Topics: Acetylcholine; Adenosine Triphosphate; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Alprostadil; Animals; Atropine; Cyclic GMP; Electric Stimulation; Endothelium, Vascular; Isoenzymes; Isoproterenol; Macaca nemestrina; Male; Microcirculation; Models, Biological; Muscarinic Antagonists; Muscle, Smooth; Muscle, Smooth, Vascular; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Penile Erection; Penis; Propranolol; Second Messenger Systems; Vasodilator Agents | 2000 |
Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta.
Topics: Administration, Cutaneous; Animals; Antioxidants; Aorta; Ascorbic Acid; Cell Adhesion Molecules; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Enzyme Induction; Guanylate Cyclase; Infusion Pumps, Implantable; Infusions, Intravenous; Male; Microfilament Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroglycerin; Phosphoproteins; Rabbits; Rats; Rats, Wistar; Second Messenger Systems; Superoxides; Vasodilator Agents | 2001 |
Selected contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media tone.
Topics: Animals; Calcium; Carotid Artery, Common; Colforsin; Cyclic AMP; Cyclic GMP; Heat-Shock Proteins; HSP20 Heat-Shock Proteins; In Vitro Techniques; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Phosphoproteins; Phosphorylation; Signal Transduction; Swine; Vasodilator Agents | 2001 |
Nitroglycerin-induced relaxation of anorectal smooth muscle: evidence for apparent lack of tolerance development in the anaesthetized rat.
Topics: Anal Canal; Anesthesia; Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitroglycerin; Rats; Rats, Sprague-Dawley; Rectum; Time Factors | 2001 |
Downregulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Aorta, Thoracic; Blood Pressure; Calcimycin; Cyclic GMP; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Guanylate Cyclase; Heart Rate; Hypertension; In Vitro Techniques; Ionophores; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroglycerin; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Chloride, Dietary; Solubility; Species Specificity; Vasodilation; Vasodilator Agents | 2001 |
Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Induction; In Vitro Techniques; Isoenzymes; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation; Vasodilator Agents; Vinca Alkaloids | 2001 |
Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione.
Topics: Animals; Blood Platelets; Buthionine Sulfoximine; Coronary Thrombosis; Cyclic GMP; Female; Glutathione; Humans; Male; Nitric Oxide Donors; Nitroglycerin; Oxidation-Reduction; Platelet Aggregation; Rabbits; Smoking | 2001 |
KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dogs; Dose-Response Relationship, Drug; Imidazoles; Isoenzymes; Kinetics; Molecular Structure; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Platelet Aggregation Inhibitors; Purines; Quinazolines; Rabbits; Sildenafil Citrate; Sulfones | 2001 |
Lack of critical involvement of endothelial nitric oxide synthase in vascular nitrate tolerance in mice.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroglycerin; Vasodilation; Vasodilator Agents | 2002 |
Dexamethasone inhibits the inducible bioconversion of glyceryl trinitrate to nitric oxide.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Dexamethasone; Endothelium, Vascular; Hemodynamics; Lipopolysaccharides; Male; Mice; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Rats; Vasodilation | 2002 |
Effects of nitric oxide donors and inhibitors of nitric oxide signalling on endothelin- and serotonin-induced contractions in human placental arteries.
Topics: Adult; Aminoquinolines; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; Female; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Placenta; Placental Circulation; Pregnancy; S-Nitroso-N-Acetylpenicillamine; Serotonin; Signal Transduction; Superoxide Dismutase; Thionucleotides; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2002 |
Cyclic AMP-mediated increase in L-type calcium current (ICa,L) by nitroglycerin in guinea-pig ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Signaling; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dialysis; Guinea Pigs; Heart Ventricles; Isoproterenol; Methylene Blue; Nitroglycerin | 2002 |
Estriol retards and stabilizes atherosclerosis through an NO-mediated system.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteriosclerosis; Cyclic GMP; Endothelium, Vascular; Estriol; Female; Immunohistochemistry; In Vitro Techniques; Isometric Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroglycerin; omega-N-Methylarginine; Rabbits; RNA, Messenger | 2002 |
Sildenafil (Viagra) augments sodium nitroprusside-induced but not nitroglycerin-induced hypotension in dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cyclic GMP; Dogs; Drug Synergism; Female; Hypotension; Male; Nitroglycerin; Nitroprusside; Piperazines; Purines; Sildenafil Citrate; Sulfones; Vasodilator Agents | 2002 |
Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Infarction, Middle Cerebral Artery; Muscle Relaxation; Muscle, Smooth, Vascular; Neuroprotective Agents; Nitrates; Nitroglycerin; Propane; Rats; Vasodilator Agents | 2002 |
Effects of glutathione S-transferase inhibitors on nitroglycerin action in pig isolated coronary arteries.
Topics: Animals; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutathione Transferase; In Vitro Techniques; Male; Nitroglycerin; Swine; Vasodilation | 2002 |
Mechanisms underlying the hydrogen peroxide-induced, endothelium-independent relaxation of the norepinephrine-contraction in guinea-pig aorta.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Guinea Pigs; Hydrogen Peroxide; In Vitro Techniques; Male; Methylene Blue; Myosin Light Chains; Nitroglycerin; Norepinephrine; Oxadiazoles; Phosphorylation; Purinones; Quinoxalines; Rats; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Maturation alters cyclic nucleotide and relaxation responses to nitric oxide donors in ovine cerebral arteries.
Topics: Aging; Animals; Animals, Newborn; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Nitric Oxide Donors; Nitroglycerin; Nucleotides, Cyclic; Osmolar Concentration; S-Nitroso-N-Acetylpenicillamine; Sheep; Vasodilation | 2003 |
Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects.
Topics: Acetylcysteine; Adenosine Diphosphate; Adult; Amifostine; Antioxidants; Collagen; Cyclic GMP; Drug Resistance; Female; Free Radical Scavengers; Humans; Insulin Resistance; Male; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Obesity; Platelet Aggregation; Platelet Aggregation Inhibitors; Superoxide Dismutase | 2003 |
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Guanylate Cyclase; Male; Mesenteric Arteries; Mice; Mice, Inbred Strains; Mice, Knockout; Muscle Relaxation; Natriuretic Peptide, C-Type; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Oxides; Nitroglycerin; Oxadiazoles; Phenylephrine; Polysaccharides; Quinoxalines; Receptors, Atrial Natriuretic Factor; Signal Transduction; Spermine | 2003 |
[Myogenic effects of cyclic guanosine monophosphate in smooth muscle cells. Role of protein kinase C].
Topics: Action Potentials; Animals; Colon; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nitroglycerin; Nitroprusside; Protein Kinase C; Ureter | 2003 |
Roles of superoxide, peroxynitrite, and protein kinase C in the development of tolerance to nitroglycerin.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Drug Tolerance; Enzyme Activation; Nitroglycerin; Peroxynitrous Acid; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superoxides | 2004 |
Role of PKC in the attenuation of the cGMP-mediated relaxation of skinned resistance artery smooth muscle seen in glyceryl-trinitrate-tolerant rabbit.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitroglycerin; Protein Kinase C; Rabbits; Vasodilation | 2004 |
Delayed cardioprotection afforded by nitroglycerin is mediated by alpha-CGRP via activation of inducible nitric oxide synthase.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Cyclic GMP; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Nitric Oxide Synthase; Nitroglycerin; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Vasodilator Agents | 2004 |
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Cyclic GMP; Drug Tolerance; Mitochondria; Models, Animal; Myocardium; Nitroglycerin; Rats; Rats, Wistar; Reactive Oxygen Species; Vasodilator Agents | 2004 |
A common pathway of nitric oxide release from AZD3582 and glyceryl trinitrate.
Topics: Animals; Cyclic GMP; Cyclooxygenase Inhibitors; LLC-PK1 Cells; Molsidomine; Naphthalenes; Naproxen; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Swine | 2004 |
Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction.
Topics: Adult; Blood Flow Velocity; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hyperemia; Hypertension; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; Smoking; Thromboxane B2; Vasodilation; Vasodilator Agents | 2004 |
Nitroglycerin enhances cGMP expression in specific neuronal and cerebrovascular structures of the rat brain.
Topics: Animals; Arterioles; Brain; Cerebrovascular Circulation; Cyclic GMP; Disease Models, Animal; Immunohistochemistry; Male; Migraine Disorders; Neurons; Nitroglycerin; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilator Agents | 2004 |
Cyclic GMP-mediated activation of a glibenclamide-sensitive mechanism in the rabbit sphincter of Oddi.
Topics: Animals; Cyclic GMP; Gastrointestinal Agents; Glyburide; Male; Nitric Oxide; Nitroglycerin; Potassium Channels; Rabbits; Sphincter of Oddi; Vasoactive Intestinal Peptide | 2004 |
Nitric oxide relaxes rat tail artery smooth muscle by cyclic GMP-independent decrease in calcium sensitivity of myofilaments.
Topics: Actin Cytoskeleton; Animals; Arteries; Calcium; Cyclic GMP; Membrane Potentials; Muscle, Smooth; Nitric Oxide; Nitroglycerin; Nitroprusside; Rats; Time Factors | 2004 |
Sevoflurane promotes endothelium-dependent smooth muscle relaxation in isolated human omental arteries and veins.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Arteries; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Male; Methyl Ethers; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroglycerin; Omentum; Potassium Chloride; Regional Blood Flow; Sevoflurane; Substance P; Vasodilator Agents; Veins | 2004 |
Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model.
Topics: Adenosine; Aldehyde Dehydrogenase; Animals; Biotransformation; Blood Pressure; Coronary Circulation; Cyanamide; Cyclic GMP; Diastole; Dogs; Mitochondria; Nitrites; Nitroglycerin; Nitroprusside; Vasodilation | 2004 |
Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Biotransformation; Cattle; Cell Line; Cyclic GMP; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Liver; Lung; Male; Microsomes; Mitochondria, Liver; Nitric Oxide; Nitroglycerin; Oxygen Consumption; Rats; Solubility | 2005 |
Formation of releasable NO stores by S-nitrosoglutathione in arteries exhibiting tolerance to glyceryl-trinitrate.
Topics: Acetylcysteine; Analysis of Variance; Animals; Aorta, Thoracic; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Nitric Oxide; Nitrogen Oxides; Nitroglycerin; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thionucleotides; Vasoconstriction; Vasodilation | 2005 |
Synthesis and ocular effects of imidazole nitrolic acids.
Topics: Animals; Aqueous Humor; Cyclic GMP; Drug Design; Imidazoles; Iris; Models, Molecular; Molecular Structure; Nitrates; Nitrites; Nitroglycerin; Swine | 2005 |
Rosuvastatin treatment protects against nitrate-induced oxidative stress.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitroglycerin; Oxidative Stress; Phenylephrine; Pyrimidines; Rats; Rats, Wistar; Reactive Oxygen Species; Rosuvastatin Calcium; Sulfonamides; Vasodilation | 2005 |
An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.
Topics: Aldehyde Dehydrogenase; Animals; Blood Pressure; Blotting, Western; Cells, Cultured; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Guanylate Cyclase; Mice; Mice, Knockout; Mitochondria; Nitric Oxide; Nitroglycerin; Rats; Signal Transduction; Vasodilation | 2005 |
Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
Topics: Animals; Carbachol; Carbolines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tadalafil; Tetrodotoxin | 2006 |
Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungs.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclic GMP; Death; Enzyme Activation; Guanylate Cyclase; Hemodynamics; Lung; Lung Transplantation; Models, Animal; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Rats; Reperfusion Injury; Respiration, Artificial; Tissue Donors | 2006 |
Glyceryl trinitrate-induced angiotensin-converting enzyme (ACE) inhibition in healthy volunteers is dependent on ACE genotype.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cyclic GMP; Female; Genotype; Humans; Male; Middle Aged; Nitroglycerin; Peptidyl-Dipeptidase A; Vasodilator Agents | 2005 |
Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress.
Topics: alpha-Tocopherol; Animals; Aorta; Cell Adhesion Molecules; Cyclic GMP; Cytochrome P-450 CYP1A2; Down-Regulation; Drug Tolerance; Lipid Peroxidation; Male; Microfilament Proteins; Myocardium; Nitrates; Nitric Oxide; Nitroglycerin; Oxidative Stress; Phosphoproteins; Phosphorylation; Rats; Reactive Oxygen Species; Serine; Vasodilator Agents; Vitamin E; Vitamin E Deficiency | 2006 |
Ramipril treatment protects against nitrate-induced oxidative stress in eNOS-/- mice: An implication of the NADPH oxidase pathway.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Bradykinin; Cyclic GMP; Female; In Vitro Techniques; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; Nitroglycerin; Oxidative Stress; Ramipril; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasodilation | 2006 |
Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Electron Transport Complex I; Endothelial Cells; Glutathione; Humans; In Vitro Techniques; Male; Mitochondria; Mitochondrial Proteins; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Organophosphorus Compounds; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Ubiquinone; Vasodilator Agents | 2006 |
Effect of nitroglycerine on content of second messengers in myocytes of rat thoracic aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Muscle Cells; Nitroglycerin; Norepinephrine; Rats; Second Messenger Systems; Time Factors; Vasodilator Agents | 2006 |
Manipulating glutathione-S-transferases may prevent the development of tolerance to nitroglycerin.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cyclic GMP; Drug Tolerance; Endothelial Cells; Glutathione Transferase; Mice; Microscopy, Confocal; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroglycerin; Oxidative Stress; Peroxynitrous Acid; Signal Transduction; Transfection; Vasodilator Agents | 2006 |
Restoration of impaired endothelium-dependent coronary vasodilation in failing heart: role of eNOS phosphorylation and CGMP/cGK-I signaling.
Topics: Acetylcholine; Animals; Bradykinin; Coronary Circulation; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Dogs; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Heart Failure; Male; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroglycerin; Phosphoproteins; Phosphorylation; Recovery of Function; RNA, Messenger; Signal Transduction; Vasodilation; Vasodilator Agents; Ventricular Function, Left | 2007 |
cGMP-dependent protein kinase in regulation of basal tone and in nitroglycerin- and nitric-oxide-induced relaxation in porcine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blotting, Western; Coronary Vessels; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Swine; Vasoconstrictor Agents; Vasodilator Agents | 2007 |
Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cyclic GMP; Drug Resistance, Neoplasm; Female; Humans; Isosorbide Dinitrate; Male; Mice; Neoplasms, Experimental; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Prostatic Neoplasms; Signal Transduction | 2007 |
Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates.
Topics: Aldehyde Dehydrogenase; Animals; Chromatography, High Pressure Liquid; Cyclic GMP; Disease Models, Animal; Drug Tolerance; Endothelium, Vascular; Free Radical Scavengers; Heme Oxygenase-1; Male; Nitroglycerin; Pentaerythritol Tetranitrate; Probability; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Reference Values; Sensitivity and Specificity | 2007 |
Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2.
Topics: Acetylcysteine; Aldehyde Dehydrogenase; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Calcitonin Gene-Related Peptide; Captopril; Cell Line; Chloral Hydrate; Cyanamide; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Endothelial Cells; Humans; In Vitro Techniques; Male; Nitric Oxide Donors; Nitroglycerin; Rats; Rats, Wistar; Reactive Oxygen Species; Vasodilation | 2007 |
Nitroglycerin on contractile force in canine cardiac Purkinje fibers.
Topics: Animals; Cardiotonic Agents; Cobalt; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Isoproterenol; Methylene Blue; Muscle Strength; Myocardial Contraction; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Potassium; Potassium Channel Blockers; Purkinje Fibers; Tetraethylammonium | 2007 |
Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination.
Topics: Adolescent; Adult; Biomarkers; Brachial Artery; C-Reactive Protein; Carotid Artery, Common; Cholesterol, HDL; Cyclic GMP; Endothelium, Vascular; Fibrinogen; Follow-Up Studies; Humans; Hyperemia; Inflammation; Influenza Vaccines; Lipoproteins, LDL; Male; Nitroglycerin; Research Design; Ultrasonography; Vasodilation; Vasodilator Agents | 2007 |
Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins.
Topics: Animals; Coronary Vessels; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Nitric Oxide; Nitroglycerin; Nitroso Compounds; Organ Culture Techniques; Protein Kinase Inhibitors; Radioimmunoassay; Swine; Thionucleotides; Vasodilation; Vasodilator Agents; Veins | 2007 |
Role of cGMP-dependent protein kinase in development of tolerance to nitroglycerine in porcine coronary arteries.
Topics: Animals; Blotting, Western; Coronary Vessels; Cyclic GMP; Down-Regulation; Drug Administration Schedule; Drug Tolerance; In Vitro Techniques; Nitroglycerin; Polymerase Chain Reaction; Protein Kinases; Reactive Oxygen Species; RNA, Messenger; Superoxides; Swine; Vasodilator Agents | 2008 |
Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2.
Topics: Acetylcysteine; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Amidohydrolases; Arginine; Cell Line; Cyclic GMP; Drug Tolerance; Endothelial Cells; Humans; Lipid Peroxides; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroglycerin; Oxidative Stress; Reactive Oxygen Species | 2008 |
Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Cyclic GMP; Female; Genotype; Heart Rate; Humans; Male; Middle Aged; Middle Cerebral Artery; Migraine with Aura; Nitric Oxide; Nitroglycerin; Sodium-Potassium-Exchanging ATPase; Temporal Arteries; Vasodilator Agents | 2008 |
Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitochondrial; Animals; Catalysis; Cattle; Cyclic GMP; Cytosol; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Mitochondria; Muscle, Smooth, Vascular; Nitroglycerin; Protein Isoforms; Retinal Dehydrogenase; Serum Albumin | 2008 |
Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Tolerance; Male; Naphthyridines; Nitric Oxide; Nitroglycerin; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Vasodilation | 2008 |
Dissociation between superoxide accumulation and nitroglycerin-induced tolerance.
Topics: Angiotensin II; Animals; Aorta; Cyclic GMP; Drug Tolerance; LLC-PK1 Cells; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Nitroglycerin; Superoxides; Vasodilation | 2008 |
Nitroglycerin protects small intestine from ischemia-reperfusion injury via NO-cGMP pathway and upregulation of alpha-CGRP.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic GMP; Guanylate Cyclase; Intestine, Small; Ischemic Preconditioning; Male; Nitric Oxide; Nitroglycerin; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents | 2009 |
Combined use of PDE5 inhibitors and nitrates in the treatment of pulmonary arterial hypertension in patients with heart failure.
Topics: Cyclic GMP; Drug Therapy, Combination; Heart Failure; Humans; Hypertension, Pulmonary; Isosorbide Dinitrate; Male; Middle Aged; Nitro Compounds; Nitroglycerin; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2009 |
Role of glutaredoxin-mediated protein S-glutathionylation in cellular nitroglycerin tolerance.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Creatine Kinase; Cyclic GMP; Drug Tolerance; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Glutaredoxins; Glutathione; Humans; LLC-PK1 Cells; Nitroglycerin; Oxidation-Reduction; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Swine; Transfection; Vasodilation; Vasodilator Agents | 2009 |
Role of microsomal glutathione transferase 1 in the mechanism-based biotransformation of glyceryl trinitrate in LLC-PK1 cells.
Topics: Animals; Biotransformation; Cell Division; Cyclic GMP; Glutamine; Glutathione Transferase; Insulin; LLC-PK1 Cells; Mice; Microscopy, Confocal; Microsomes; NADPH-Ferrihemoprotein Reductase; Nitroglycerin; Swine | 2009 |
Demethylbellidifolin prevents nitroglycerin tolerance via improved aldehyde dehydrogenase 2 activity.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Aorta; Cyclic GMP; Drug Tolerance; Endothelial Cells; Herb-Drug Interactions; Humans; Male; Mitochondrial Proteins; Nitroglycerin; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Swertia; Umbilical Veins; Vasodilator Agents; Xanthenes | 2009 |
Vasodilator efficacy of nitric oxide depends on mechanisms of intracellular calcium mobilization in mouse aortic smooth muscle cells.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcium; Calcium Channels, L-Type; Cyclic GMP; Hydrazines; In Vitro Techniques; Intracellular Space; Membrane Potentials; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Vasodilation | 2009 |
Degradation of leucine zipper-positive isoform of MYPT1 may contribute to development of nitrate tolerance.
Topics: Animals; Aorta; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Tolerance; Leucine Zippers; Male; Mice; Mice, Inbred C57BL; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Nitric Oxide; Nitroglycerin; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Sus scrofa; Vasodilation; Vasodilator Agents | 2010 |
Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Arteries; Bradykinin; Coronary Vessels; Cyclic GMP; Drug Tolerance; Morpholines; Nitroglycerin; Nitroprusside; Pyrazoles; Pyrimidines; Quercetin; Sus scrofa; Swine; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
Differences between nitrates: role of isosorbide 2-mononitrate.
Topics: Animals; Aorta; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitroglycerin; Perfusion; Rabbits; Vasodilation; Vasodilator Agents | 2010 |
Coadministration of carvedilol attenuates nitrate tolerance by preventing cytochrome p450 depletion.
Topics: Animals; Carbazoles; Carvedilol; Cell Adhesion Molecules; Cyclic GMP; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Drug Tolerance; Free Radicals; Male; Microfilament Proteins; Nitric Oxide; Nitroglycerin; Phosphoproteins; Propanolamines; Rats; Superoxides | 2010 |
Chronic administration of the HNO donor Angeli's salt does not lead to tolerance, cross-tolerance, or endothelial dysfunction: comparison with GTN and DEA/NO.
Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Diethylamines; In Vitro Techniques; Male; Nitric Oxide Donors; Nitrites; Nitrogen Oxides; Nitroglycerin; Rats | 2011 |
Block by nitrate tolerance of meal-induced insulin sensitization in conscious rabbits.
Topics: Animals; Blood Glucose; Blood Pressure; Cyclic GMP; Drug Tolerance; Eating; Fasting; Glucose Clamp Technique; Heart Rate; Insulin Resistance; Liver; Male; Nitroglycerin; Rabbits; Sincalide | 2011 |
Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1.
Topics: Animals; Cell Adhesion Molecules; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Microfilament Proteins; Models, Animal; Myosin-Light-Chain Phosphatase; Nitric Oxide; Nitroglycerin; Nitroso Compounds; Phosphoproteins; Phosphorylation; Signal Transduction; Swine; Vasodilation; Vasodilator Agents | 2012 |
Inhibition of phosphoinositide 3-kinase potentiates relaxation of porcine coronary arteries induced by nitroglycerin by decreasing phosphodiesterase type 5 activity.
Topics: Animals; Chromones; Coronary Vessels; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Milrinone; Models, Animal; Morpholines; Nifedipine; Nitroglycerin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purinones; Signal Transduction; Swine; Vasodilation; Vasodilator Agents | 2012 |
Evidence for a relationship between mitochondrial Complex I activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: effects of mitochondrial antioxidants.
Topics: Aldehyde Dehydrogenase; Animals; Antioxidants; Aorta; Biotransformation; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Electron Transport Complex I; Glutathione; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Male; Mice; Mitochondria; Mutation; Nitroglycerin; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; Vasodilation | 2012 |
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.
Topics: Animals; Aorta; Biopterins; Cardiovascular Diseases; Cells, Cultured; Cyclic GMP; Endothelial Cells; Fibroblasts; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Pterins; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Swine | 2012 |
P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins.
Topics: Acetylation; Actins; Animals; Aorta; Benzamides; Cyclic GMP; Histone Deacetylase Inhibitors; Hydroxamic Acids; Injections, Subcutaneous; Lysine; Male; Models, Animal; Muscle Contraction; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroglycerin; p300-CBP Transcription Factors; Pyridines; Rats; Valproic Acid; Vasodilation | 2012 |
Supplementation of nitric oxide attenuates AβPP and BACE1 protein in cerebral microcirculation of eNOS-deficient mice.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cerebrovascular Circulation; Cyclic GMP; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroglycerin; Protein Processing, Post-Translational; Signal Transduction | 2013 |
Effect of overexpression of human aldehyde dehydrogenase 2 in LLC-PK1 cells on glyceryl trinitrate biotransformation and cGMP accumulation.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cell Culture Techniques; Cyclic GMP; Humans; Immunoblotting; LLC-PK1 Cells; Microscopy, Confocal; Microscopy, Fluorescence; Nitroglycerin; RNA, Small Interfering; Swine; Transfection | 2013 |
The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Blood Platelets; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Humans; Hypotension; Isosorbide Dinitrate; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Rats; Thrombin; Tyrosine; Vasodilator Agents | 2014 |
Role of Ser102 and Ser104 as regulators of cGMP hydrolysis by PDE5A.
Topics: Amino Acid Substitution; Calcitonin Gene-Related Peptide; Catalytic Domain; Cell Line; Cilostazol; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; In Vitro Techniques; Models, Molecular; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Serine; Sildenafil Citrate; Sulfonamides; Sumatriptan; Tetrazoles | 2014 |
Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance.
Topics: Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Nitric Oxide Donors; Nitrites; Nitrogen Oxides; Nitroglycerin; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Radial Artery; Receptors, Cytoplasmic and Nuclear; Saphenous Vein; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2015 |
Effect of Shenmai injection on preventing the development of nitroglycerin-induced tolerance in rats.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Drug Combinations; Drug Tolerance; Drugs, Chinese Herbal; Echocardiography; Endothelium; Male; Models, Animal; Nitroglycerin; Oxidative Stress; Random Allocation; Rats, Sprague-Dawley; Signal Transduction; Tissue Culture Techniques; Vasodilator Agents | 2017 |
Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo.
Topics: Animals; Blood Pressure; Cardiomegaly; Connectin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Desoxycorticosterone Acetate; Female; Heart Ventricles; Morpholines; Nitroglycerin; Pyrimidines; Soluble Guanylyl Cyclase; Swine; Vascular Capacitance; Vasodilator Agents; Ventricular Function, Left | 2018 |
Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate.
Topics: Calpain; Cell Line, Tumor; Cyclic GMP; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Prostatic Neoplasms; Signal Transduction; Tumor Hypoxia; Tumor Microenvironment | 2020 |