nitroglycerin and ascorbic acid

nitroglycerin has been researched along with ascorbic acid in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (6.06)	18.7374
1990's	13 (19.70)	18.2507
2000's	41 (62.12)	29.6817
2010's	7 (10.61)	24.3611
2020's	1 (1.52)	2.80

Authors

Authors	Studies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Adams, HR; Krishnamurty, VS; Templeton, GH; Willerson, JT	1
Allison, WS; Benitez, LV; McConachie, WA	1
Kawakami, M; Kodama, N; Toda, N	1
Drummer, OH; Henry, PJ; Horowitz, JD	1
Gross, GJ; Pieper, GM	1
Bailey, Y; Dunkley, H; Hamilton, T; Simon, OR; Thomas, E	1
Bassenge, E; Fink, B	2
Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H	2
Hinz, B; Schröder, H	1
Bassenge, E; Fink, B; Fink, N; Skatchkov, M	1
Akita, H; Ito, K; Kanazawa, K; Matsuda, Y; Terashima, M; Yamada, S; Yokoyama, M	1
Azevedo, ER; Milone, SD; Newton, GE; Pace-Asciak, CR; Parker, JD; Reynaud, D	1
Bassenge, E; Dikalov, S; Fink, B; Skatchkov, M	1
Milone, SD; Newton, GE; Parker, JD	1
Bassenge, E; Fink, B; Fink, N; Schwemmer, M	1
Bassenge, E; Dikalov, S; Fink, B	1
Adams, MR; Celermajer, DS; Griffiths, KA; McCredie, RJ; Raitakari, OT; Stocker, R	1
Bassenge, E; Fink, B; Köckerbauer, R; Schwemmer, M	1
Fang, JC; Frei, B; Ganz, P; Hikita, H; Kinlay, S; Morrow, JD; Piana, RN; Selwyn, AP; Suh, JH	1
Cummings, PM; Genest, JJ; Giddens, K; Nassar, BA; Title, LM	1
Daniel, TA; Nawarskas, JJ	1
Chambers, JC; Haskard, DO; Kooner, JS	1
Chambers, JC; De Swiet, M; Fusi, L; Haskard, DO; Kooner, JS; Malik, IS	1
Holubarsch, C; Jeserich, M; Just, H; Magosaki, N; Nitzsche, E; Olschewski, M; Schindler, TH; Solzbach, U	1
Hink, U; Klöss, S; Meinertz, T; Mollnau, H; Mülsch, A; Münzel, T; Oelze, M; Smolenski, A; Stasch, JP; Töpfer, A; Walter, U; Warnholtz, A	1
Anderson, RA; Chirkov, YY; Ellis, GR; Frenneaux, MP; Horowitz, JD; Jackson, SK; Lewis, MJ; Morris-Thurgood, J	1
Ascenzi, P; Colasanti, M; Gradoni, L; Mattu, M; Salvati, L; Scalone, A; Venturini, G	1
Hamabe, A; Kurita, A; Ohsuzu, F; Takase, B; Tamai, S; Uehata, A	1
de Jong, SA; McCormick, MP; McDonald, JR; Sutherland, WH; Walker, RJ; Williams, MJ	1
Chowienczyk, PJ; de Saram, K; Khokher, S; McNeill, KL; Ritter, JM	1
Kuji, N; Masumori-Maemoto, S; Sugimoto, K; Ueda, S; Umemura, S; Wada, A	1
Kleschyov, A; Mülsch, A; Münzel, T	1
Devine, AB; Dixon, LJ; Hamilton, P; Hanratty, CG; Leahey, WJ; McGrath, LT; McVeigh, GE; Morgan, DG; Wilson, M	1
Bonham, JR; Lee, PJ; Lewis, MJ; McDowell, IF; Moat, SJ; Powers, HJ; Pullin, CH; Wilson, JF	1
Dixon, L; McGrath, LT; McVeigh, GE; Morgan, DR	1
MacAllister, RJ; Mittermayer, F; Pleiner, J; Schaller, G; Wolzt, M	1
Graves, J; MacAllister, RJ; Singer, DR; Singh, N; Taylor, PD	1
Chang, Q; Deng, YB; Li, CL; Li, TL; Xiang, HJ	1
Battaglia, C; Calabrò, R; Cappelli-Bigazzi, M; Carrozza, M; Pacileo, G; Palladino, MT; Russo, MG; Santoro, G	1
Clapp, BR; Hingorani, AD; Kharbanda, RK; MacAllister, RJ; Mohamed-Ali, V; Stephens, JW; Vallance, P	1
Bayerle-Eder, M; Bieglmayer, C; Mittermayer, F; Pleiner, J; Roden, M; Schaller, G; Waldhäusl, W; Wolzt, M	1
Coleman, HA; von der Weid, PY	1
Itoh, T; Kajikuri, J; Katsuya, H; Kusama, N; Suzuki, Y; Watanabe, Y; Yamamoto, T	1
Eisele, HJ; Grebe, M; Schaefer, C; Schulz, R; Seeger, W; Tillmanns, H; Weissmann, N	1
Antoine, M; Berkenboom, G; Carpentier, Y; Goldman, M; Pradier, O; Preumont, N; Vachiery, JL	1
Beretta, M; Gorren, AC; Koesling, D; Kollau, A; Mayer, B; Russwurm, M; Schmidt, K	1
Gulati, K; Ray, A; Vijayan, VK	1
Brubakk, AO; Dujić, Z; Modun, D; Obad, A; Palada, I; Valic, Z	1
Beretta, M; Mayer, B; Schmidt, K; Stessel, H; Wenzl, MV; Wölkart, G	2
Daiber, A; Gori, T	1
Beretta, M; Gorren, AC; Mayer, B; Schmidt, K; Sottler, A	1
Miller, MR; Wadsworth, RM	1
Bøtker, HE; Contractor, H; Kharbanda, RK; Mortensen, B; Pedersen, CM; Schmidt, MR; Sørensen, KE	1
Daiber, A; Di Stolfo, G; Dragoni, S; Gori, T; Liuni, A; Luca, MC; Oelze, M; Parker, JD; Sicuro, S; Thomas, G	1
Csont, T	1
Gori, T; Parker, JD; Perampaladas, K	1
Bütün, A; Çelik, Ö; Demirci, S; Nazıroğlu, M; Uğuz, AC	1
He, JD; Parker, JD	1

Reviews

2 review(s) available for nitroglycerin and ascorbic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Vitamin C in the prevention of nitrate tolerance. The Annals of pharmacotherapy, 2000, Volume: 34, Issue:10 Topics: Antioxidants; Ascorbic Acid; Drug Tolerance; Hemodynamics; Humans; Nitrates; Nitroglycerin; Vasodilator Agents	2000

Trials

19 trial(s) available for nitroglycerin and ascorbic acid

Article	Year
Randomized, double-blind, placebo-controlled study of ascorbate on the preventive effect of nitrate tolerance in patients with congestive heart failure. Circulation, 1998, Mar-10, Volume: 97, Issue:9 Topics: Aged; Ascorbic Acid; Blood Platelets; Blood Pressure; Cyclic GMP; Double-Blind Method; Drug Tolerance; Female; Heart Failure; Humans; Infusions, Intravenous; Male; Nitroglycerin; Vitamin E	1998
Randomized, double-blind, placebo-controlled study of the preventive effect of supplemental oral vitamin C on attenuation of development of nitrate tolerance. Journal of the American College of Cardiology, 1998, Volume: 31, Issue:6 Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cyclic GMP; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Plethysmography; Vasodilator Agents	1998
Dietary supplement with vitamin C prevents nitrate tolerance. The Journal of clinical investigation, 1998, Jul-01, Volume: 102, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Ascorbic Acid; Blood Platelets; Blood Pressure; Calcium; Cyclic GMP; Diet; Drug Tolerance; Female; Humans; Male; Middle Aged; Nitroglycerin; Superoxides	1998
Biochemical, hemodynamic, and vascular evidence concerning the free radical hypothesis of nitrate tolerance. Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:5 Topics: Administration, Cutaneous; Antioxidants; Ascorbic Acid; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Forearm; Free Radicals; Hemodynamics; Humans; Male; Nitroglycerin; Oxidative Stress; Plethysmography; Veins	1999
Hemodynamic and biochemical effects of 100% oxygen breathing in humans. Canadian journal of physiology and pharmacology, 1999, Volume: 77, Issue:2 Topics: Adult; Ascorbic Acid; Cross-Over Studies; Double-Blind Method; Free Radicals; Hemodynamics; Humans; Male; Nitroglycerin; Oxygen; Plethysmography	1999
Oral vitamin C and endothelial function in smokers: short-term improvement, but no sustained beneficial effect. Journal of the American College of Cardiology, 2000, Volume: 35, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Antioxidants; Ascorbic Acid; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Follow-Up Studies; Humans; Male; Middle Aged; Nitroglycerin; Smoking; Vasodilation; Vasodilator Agents	2000
Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. Journal of the American College of Cardiology, 2000, Volume: 36, Issue:3 Topics: Aged; Antioxidants; Ascorbic Acid; Blood Circulation; Coronary Disease; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Malondialdehyde; Middle Aged; Nitroglycerin; Vasodilation; Vasodilator Agents; Vitamin B 12; Vitamin E	2000
Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing. Cardiology, 2000, Volume: 94, Issue:4 Topics: Aged; Antioxidants; Ascorbic Acid; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cold Temperature; Coronary Vessels; Double-Blind Method; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitroglycerin; Prospective Studies; Smoking; Vasoconstriction; Vasodilation; Vasodilator Agents	2000
Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure. Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:5 Topics: Adult; Aged; Analysis of Variance; Antioxidants; Ascorbic Acid; Chronic Disease; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Heart Failure; Humans; Linear Models; Male; Middle Aged; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Oxidative Stress; Platelet Aggregation; Vasodilator Agents	2001
Impaired endothelium-dependent vasodilation in the brachial artery in variant angina pectoris and the effect of intravenous administration of vitamin C. The American journal of cardiology, 2001, May-15, Volume: 87, Issue:10 Topics: Angina Pectoris, Variant; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Cross-Over Studies; Endothelium, Vascular; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Nitroglycerin; Single-Blind Method; Ultrasonography, Doppler, Pulsed; Vasodilation	2001
Vitamin C improves endothelial dysfunction in renal allograft recipients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:6 Topics: Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Cholesterol; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Heart Rate; Humans; Kidney Transplantation; Male; Nitroglycerin; Placebos; Vasodilation	2001
Platelet nitric oxide and superoxide release during the development of nitrate tolerance: effect of supplemental ascorbate. Circulation, 2002, Jul-09, Volume: 106, Issue:2 Topics: Adult; Antioxidants; Ascorbic Acid; Blood Platelets; Cross-Over Studies; Cyclic GMP; Double-Blind Method; Drug Tolerance; Free Radicals; Hemodynamics; Humans; Male; Middle Aged; NAD; NADPH Oxidases; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroglycerin; Superoxides; Time Factors; Vasodilator Agents	2002
High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm. Circulation, 2002, Sep-17, Volume: 106, Issue:12 Topics: Acetylcholine; Adult; Antioxidants; Ascorbic Acid; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Escherichia coli; Forearm; Humans; Inflammation; Lipopolysaccharides; Male; Nitroglycerin; Oxidative Stress; Plethysmography; Regional Blood Flow; Vasodilation; Vasodilator Agents	2002
Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects. Cardiovascular research, 2002, Volume: 56, Issue:1 Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Area Under Curve; Ascorbic Acid; Bradykinin; Diet, Mediterranean; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Forearm; Humans; Injections, Intra-Arterial; Male; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroglycerin; Plethysmography; Regional Blood Flow; Statistics, Nonparametric; Vasodilator Agents	2002
Association between vascular tolerance and platelet upregulation: comparison of nonintermittent administration of pentaerithrityltetranitrate and glyceryltrinitrate. Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:6 Topics: Adult; Ascorbic Acid; Blood Platelets; Drug Interactions; Female; Hemodynamics; Humans; Male; Middle Aged; Nitroglycerin; Pentaerythritol Tetranitrate; Platelet Aggregation; Up-Regulation; Vasodilation; Vasodilator Agents	2002
Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress. Cardiovascular research, 2004, Oct-01, Volume: 64, Issue:1 Topics: Adult; Albuminuria; Analysis of Variance; Arginine; Ascorbic Acid; Biological Availability; Bradykinin; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Forearm; Humans; Male; Nitric Oxide; Nitroglycerin; Norepinephrine; omega-N-Methylarginine; Oxidative Stress; Plethysmography; Regional Blood Flow; Statistics, Nonparametric; Typhoid-Paratyphoid Vaccines; Vasoconstrictor Agents; Vasodilator Agents	2004
Effect of systemic vitamin C on free fatty acid-induced lipid peroxidation. Diabetes & metabolism, 2004, Volume: 30, Issue:5 Topics: Acetylcholine; Adult; Ascorbic Acid; Blood Glucose; Blood Pressure; Body Mass Index; Double-Blind Method; Endothelium, Vascular; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Humans; Injections, Intra-Arterial; Lipid Peroxidation; Lipids; Male; Malondialdehyde; Nitroglycerin; Vasodilation	2004
Tolerance to nitroglycerin-induced preconditioning of the endothelium: a human in vivo study. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:2 Topics: Acetylcholine; Administration, Cutaneous; Adult; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Drug Tolerance; Endothelium, Vascular; Humans; Infusions, Intra-Arterial; Ischemic Preconditioning; Male; Nitroglycerin; Plethysmography; Reperfusion Injury; Vasodilator Agents	2010
Rosiglitazone causes endothelial dysfunction in humans. Journal of cardiovascular pharmacology and therapeutics, 2012, Volume: 17, Issue:3 Topics: Acetylcholine; Adolescent; Adult; Ascorbic Acid; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Heart Rate; Humans; Male; Nitroglycerin; Rosiglitazone; Thiazolidinediones; Vasodilation; Vasodilator Agents; Young Adult	2012

Other Studies

45 other study(ies) available for nitroglycerin and ascorbic acid

Article	Year
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Inhibitory effect of hypertonic mannitol on vasoconstrictor and vasodilator responses of isolated coronary arteries. The American journal of physiology, 1978, Volume: 235, Issue:6 Topics: Animals; Ascorbic Acid; Coronary Vessels; Dogs; Ethacrynic Acid; Female; Male; Mannitol; Methoxamine; Nitroglycerin; Norepinephrine; Papaverine; Phentolamine; Phenylephrine; Propranolol; Vascular Resistance; Vasodilator Agents	1978
The conversion of glyceraldehyde-3-phosphate dehydrogenase to an acylphosphatase by trinitroglycerin and inactivation of this activity by azide and ascorbate. Biochimica et biophysica acta, 1975, Apr-19, Volume: 384, Issue:2 Topics: Animals; Ascorbic Acid; Azides; Benzoates; Binding Sites; Cyanides; Dithiothreitol; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen-Ion Concentration; Kinetics; Muscles; Nitroglycerin; Oxidation-Reduction; Phosphoric Monoester Hydrolases; Protein Binding; Sulfenic Acids; Swine	1975
Suppression of the cerebral vasospastic actions of oxyhemoglobin by ascorbic acid. Neurosurgery, 1991, Volume: 28, Issue:1 Topics: Animals; Ascorbic Acid; Aspirin; Basilar Artery; Cattle; Cerebral Arteries; Dogs; Female; Ischemic Attack, Transient; Macaca; Male; Nicotine; Nitroglycerin; Oxyhemoglobins; Potassium Chloride; Substance P; Time Factors; Vasoconstriction	1991
S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators. British journal of pharmacology, 1989, Volume: 98, Issue:3 Topics: Acetylcysteine; Animals; Ascorbic Acid; Cattle; Chromatography, High Pressure Liquid; Coronary Vessels; Cystine; Drug Tolerance; In Vitro Techniques; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents	1989
Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. The American journal of physiology, 1988, Volume: 255, Issue:4 Pt 2 Topics: Acetylcholine; Adenosine Diphosphate; Animals; Aorta, Thoracic; Ascorbic Acid; Catalase; Diabetes Mellitus, Experimental; Endothelium, Vascular; Free Radicals; In Vitro Techniques; Indomethacin; Male; Masoprocol; Nitroglycerin; Norepinephrine; Papaverine; Rats; Rats, Inbred Strains; Reference Values; Vasodilation	1988
Activation of guanylate cyclase in the guinea-pig trachea reduces contractile responses of the smooth muscle. The West Indian medical journal, 1995, Volume: 44, Issue:3 Topics: Acetylcholine; Animals; Ascorbic Acid; Carcinogens; Electric Stimulation; Guanylate Cyclase; Guinea Pigs; Histamine; Male; Muscle Contraction; Muscle, Smooth; Nitrates; Nitroglycerin; Trachea; Vasodilator Agents	1995
Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state. Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:3 Topics: Animals; Antioxidants; Ascorbic Acid; Blood Platelets; Blood Pressure; Calcium; Cyclic GMP; Dogs; Drug Interactions; Drug Synergism; Drug Tolerance; Female; Infusions, Intravenous; Male; Muscle, Smooth, Vascular; Nitroglycerin; Thrombin; Up-Regulation; Vasodilator Agents; Ventricular Function, Left	1996
Vitamin C attenuates nitrate tolerance independently of its antioxidant effect. FEBS letters, 1998, May-22, Volume: 428, Issue:1-2 Topics: Animals; Antioxidants; Ascorbic Acid; Cyclic GMP; Drug Resistance; LLC-PK1 Cells; Nitrates; Nitrogen Oxides; Nitroglycerin; Spermine; Swine	1998
Comparison of effects of ascorbic acid on endothelium-dependent vasodilation in patients with chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy versus patients with effort angina pectoris secondary to coronary artery disease. The American journal of cardiology, 1998, Sep-15, Volume: 82, Issue:6 Topics: Adult; Aged; Angina Pectoris; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Cardiomyopathy, Dilated; Coronary Disease; Endothelium, Vascular; Female; Follow-Up Studies; Heart Failure; Humans; Male; Middle Aged; Nitroglycerin; Reproducibility of Results; Ultrasonography, Doppler; Vasodilation; Vasodilator Agents	1998
Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C. Free radical biology & medicine, 1999, Volume: 27, Issue:1-2 Topics: Animals; Antioxidants; Ascorbic Acid; Female; Free Radical Scavengers; Hemodynamics; Male; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Rabbits; Superoxides; Vasodilator Agents	1999
Tolerance to nitrates with enhanced radical formation suppressed by carvedilol. Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:6 Topics: Adrenergic beta-Antagonists; Animals; Antioxidants; Ascorbic Acid; Blood Platelets; Calcium; Carbazoles; Carvedilol; Cyclic GMP; Dogs; Female; Male; Nitroglycerin; Nitroprusside; Platelet Aggregation; Propanolamines; Reactive Oxygen Species; Vasodilator Agents	1999
A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo. Free radical biology & medicine, 2000, Jan-01, Volume: 28, Issue:1 Topics: Animals; Antioxidants; Ascorbic Acid; Blood Pressure; Electron Spin Resonance Spectroscopy; Female; Free Radical Scavengers; Heart Rate; Male; Nitroglycerin; Organophosphates; Oxidants; Piperidines; Pyrrolidines; Rabbits; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Xanthine Oxidase	2000
How urine analysis reflects oxidative stress--nitrotyrosine as a potential marker. Clinica chimica acta; international journal of clinical chemistry, 2000, Volume: 297, Issue:1-2 Topics: Adult; Ascorbic Acid; Biomarkers; Chromatography, Gas; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nitroglycerin; Oxidative Stress; Reference Values; Tyrosine; Urinalysis	2000
["Intolerant" combination partners? Nitrates are still not fully utilized]. MMW Fortschritte der Medizin, 1999, Sep-02, Volume: 141, Issue:35 Topics: Angiotensin-Converting Enzyme Inhibitors; Ascorbic Acid; Drug Therapy, Combination; Drug Tolerance; Hemodynamics; Humans; Myocardial Infarction; Nitroglycerin	1999
Relation of preservation of nitric oxide-dependent coronary vasomotor function to plasma vitamin C concentrations in cardiac transplant recipients. The American journal of cardiology, 2000, Aug-15, Volume: 86, Issue:4 Topics: Acetylcholine; Adult; Aged; Antioxidants; Ascorbic Acid; Biological Availability; Chromatography, High Pressure Liquid; Coronary Vessels; Endothelium, Vascular; Female; Heart Transplantation; Humans; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Nitroglycerin; Postoperative Period; Vasodilator Agents; Vasomotor System	2000
Vascular endothelial function and oxidative stress mechanisms in patients with Behçet's syndrome. Journal of the American College of Cardiology, 2001, Volume: 37, Issue:2 Topics: Adolescent; Adult; Ascorbic Acid; Behcet Syndrome; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitroglycerin; Oxidative Stress; Vasodilation	2001
Association of maternal endothelial dysfunction with preeclampsia. JAMA, 2001, Mar-28, Volume: 285, Issue:12 Topics: Adult; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Case-Control Studies; Endothelium, Vascular; Female; Humans; Nitroglycerin; Oxidative Stress; Pre-Eclampsia; Pregnancy; Regional Blood Flow; Risk Factors; Ultrasonography; Vasodilation; Vasodilator Agents	2001
Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta. Circulation, 2001, May-01, Volume: 103, Issue:17 Topics: Administration, Cutaneous; Animals; Antioxidants; Aorta; Ascorbic Acid; Cell Adhesion Molecules; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Enzyme Induction; Guanylate Cyclase; Infusion Pumps, Implantable; Infusions, Intravenous; Male; Microfilament Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroglycerin; Phosphoproteins; Rabbits; Rats; Rats, Wistar; Second Messenger Systems; Superoxides; Vasodilator Agents	2001
NO donors inhibit Leishmania infantum cysteine proteinase activity. Biochimica et biophysica acta, 2001, Feb-09, Volume: 1545, Issue:1-2 Topics: Animals; Ascorbic Acid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dithiothreitol; Glutathione; Kinetics; Leishmania infantum; Leupeptins; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroglycerin; Nitroprusside; Nitroso Compounds; Penicillamine; Protozoan Proteins; S-Nitrosoglutathione	2001
Divergent effects of vitamin C on relaxations of rabbit aortic rings to acetylcholine and NO-donors. British journal of pharmacology, 2002, Volume: 135, Issue:4 Topics: Acetylcholine; Animals; Aorta, Thoracic; Ascorbic Acid; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Penicillamine; Rabbits; Vasodilator Agents	2002
Angiotensin II attenuates the vasodilating effect of a nitric oxide donor, glyceryl trinitrate: roles of superoxide and angiotensin II type 1 receptors. Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:6 Topics: Adult; Angiotensin Receptor Antagonists; Angiotensins; Antihypertensive Agents; Antioxidants; Ascorbic Acid; Benzimidazoles; Biphenyl Compounds; Humans; Infusions, Intra-Arterial; Male; Nitric Oxide Donors; Nitroglycerin; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reference Values; Research Design; Superoxides; Tetrazoles; Vasoconstriction; Vasodilator Agents	2002
Mechanisms underlying nitroglycerin-induced superoxide production in platelets: some insight, more questions. Circulation, 2002, Jul-09, Volume: 106, Issue:2 Topics: Antioxidants; Ascorbic Acid; Blood Platelets; Drug Tolerance; Heart Diseases; Humans; NADPH Oxidases; Nitrates; Nitric Oxide; Nitroglycerin; Platelet Aggregation Inhibitors; Superoxides; Vasodilator Agents	2002
Vitamin C therapy ameliorates vascular endothelial dysfunction in treated patients with homocystinuria. Journal of inherited metabolic disease, 2002, Volume: 25, Issue:2 Topics: Adult; Ascorbic Acid; Blood Flow Velocity; Blood Pressure; Brachial Artery; Endothelium, Vascular; Female; Heart Rate; Homocystine; Homocystinuria; Humans; Male; Methionine; Nitric Oxide; Nitroglycerin; Tetrahydrofolates; Vasodilation	2002
Production of 8-epi prostaglandin F(2alpha) in human platelets during administration of organic nitrates. Journal of the American College of Cardiology, 2002, Aug-21, Volume: 40, Issue:4 Topics: Adult; Ascorbic Acid; Blood Platelets; Dinoprost; Free Radical Scavengers; Free Radicals; Humans; Male; Middle Aged; Nitroglycerin; Vasodilator Agents	2002
Impaired endothelial function in the brachial artery after Kawasaki disease and the effects of intravenous administration of vitamin C. The Pediatric infectious disease journal, 2003, Volume: 22, Issue:1 Topics: Adolescent; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Child; Child, Preschool; Coronary Artery Disease; Endothelium, Vascular; Female; gamma-Globulins; Humans; Infusions, Intravenous; Male; Mucocutaneous Lymph Node Syndrome; Nitroglycerin; Ultrasonography; Vasodilation	2003
Endothelial cell function in patients with Down's syndrome. The American journal of cardiology, 2004, Aug-01, Volume: 94, Issue:3 Topics: Acetylcholine; Analysis of Variance; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Case-Control Studies; Child; Child, Preschool; Down Syndrome; Endothelial Cells; Endothelium, Vascular; Female; Humans; Male; Nitroglycerin; Oxidative Stress; Probability; Reference Values; Risk Assessment; Ultrasonography, Doppler, Pulsed; Vasodilation	2004
Reduced vascular reactivity after chronic nitroglycerine administration: EDHF mechanism is also downregulated. British journal of pharmacology, 2005, Volume: 146, Issue:4 Topics: Animals; Antioxidants; Ascorbic Acid; Biological Factors; Down-Regulation; Drug Tolerance; Endothelial Cells; Membrane Potentials; Nitroglycerin; Potassium Channels, Calcium-Activated; Rabbits; Vasodilator Agents	2005
Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration. British journal of pharmacology, 2005, Volume: 146, Issue:4 Topics: Acetylcholine; Animals; Antioxidants; Aortic Valve; Apamin; Ascorbic Acid; Benzimidazoles; Biological Factors; Calcium; Calcium Channel Agonists; Charybdotoxin; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Endothelial Cells; Ionomycin; Ionophores; Male; Membrane Potentials; Nitroglycerin; Potassium Channels, Calcium-Activated; Rabbits; Superoxides; Time Factors; Vasodilator Agents	2005
Antioxidant vitamin C improves endothelial function in obstructive sleep apnea. American journal of respiratory and critical care medicine, 2006, Apr-15, Volume: 173, Issue:8 Topics: Administration, Sublingual; Antioxidants; Ascorbic Acid; Brachial Artery; Endothelium, Vascular; Female; Humans; Injections, Intravenous; Male; Middle Aged; Nitroglycerin; Polysomnography; Sleep Apnea, Obstructive; Treatment Outcome; Ultrasonography; Vasodilation; Vasodilator Agents	2006
Relation of coronary hypersensitivity to serotonin in cardiac transplant recipients to vessel wall morphology and effect of vitamin C. The American journal of cardiology, 2006, Feb-15, Volume: 97, Issue:4 Topics: Adult; Ascorbic Acid; Bradykinin; Coronary Vessels; Dietary Supplements; Heart Transplantation; Humans; Hyperplasia; Isosorbide Dinitrate; Middle Aged; Nitroglycerin; Oxidative Stress; Serotonin; Time Factors; Tunica Intima; Ultrasonography, Interventional	2006
Bioactivation of nitroglycerin by ascorbate. Molecular pharmacology, 2007, Volume: 72, Issue:1 Topics: Animals; Ascorbic Acid; Biotransformation; Cells, Cultured; Enzyme Activation; Guanylate Cyclase; Hydrazines; Nitroglycerin; Rats	2007
Free radicals and theophylline neurotoxicity : an experimental study. Cellular and molecular biology (Noisy-le-Grand, France), 2007, May-30, Volume: 53, Issue:5 Topics: alpha-Tocopherol; Aminophylline; Animals; Antioxidants; Arginine; Ascorbic Acid; Dose-Response Relationship, Drug; Female; Free Radicals; Male; Melatonin; Mice; Nervous System Diseases; NG-Nitroarginine Methyl Ester; Nitroglycerin; Phosphodiesterase Inhibitors; Reactive Nitrogen Species; Reactive Oxygen Species; Seizures; Superoxide Dismutase; Theophylline	2007
Antioxidant pretreatment and reduced arterial endothelial dysfunction after diving. Aviation, space, and environmental medicine, 2007, Volume: 78, Issue:12 Topics: Adult; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Diving; Endothelium, Vascular; Humans; Hyperemia; Male; Muscle, Smooth, Vascular; Nitroglycerin; Prospective Studies; Ultrasonography; Vasodilation; Vasodilator Agents; Vitamin E	2007
Vascular tolerance to nitroglycerin in ascorbate deficiency. Cardiovascular research, 2008, Jul-15, Volume: 79, Issue:2 Topics: Aldehyde Dehydrogenase; Animals; Aorta; Ascorbic Acid; Ascorbic Acid Deficiency; Disease Models, Animal; Female; Guinea Pigs; Heart; Heart Rate; Male; Mitochondria, Liver; Nitroglycerin; Regional Blood Flow; Scurvy; Vasodilation; Vasodilator Agents	2008
Vascular tolerance to nitroglycerin in ascorbate deficiency: results are in favour of an important role of oxidative stress in nitrate tolerance. Cardiovascular research, 2008, Sep-01, Volume: 79, Issue:4 Topics: Aldehyde Dehydrogenase; Animals; Antioxidants; Ascorbic Acid; Ascorbic Acid Deficiency; Drug Tolerance; Humans; Nitroglycerin; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Research Design; Vasodilation; Vasodilator Agents	2008
Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin. The Journal of biological chemistry, 2008, Nov-07, Volume: 283, Issue:45 Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Ascorbic Acid; Cysteine; Dithiothreitol; Drug Tolerance; Enzyme Activation; Glutathione; Humans; Mitochondrial Proteins; NAD; Nitroglycerin; Recombinant Proteins; Vasodilator Agents	2008
Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin. British journal of pharmacology, 2009, Volume: 156, Issue:8 Topics: Aldehyde Dehydrogenase; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Biotransformation; Chloral Hydrate; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Hydrazines; Injections, Subcutaneous; Isoflavones; Male; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Time Factors; Vasodilation; Vasodilator Agents	2009
Understanding organic nitrates--a vein hope? British journal of pharmacology, 2009, Volume: 157, Issue:4 Topics: Aldehyde Dehydrogenase; Angina Pectoris; Animals; Ascorbic Acid; Drug Tolerance; Mitochondria; Nitrates; Nitric Oxide; Nitroglycerin; Vasodilator Agents	2009
Preserved flow-mediated dilation in adults with cyanotic congenital heart disease. Pediatric cardiology, 2009, Volume: 30, Issue:7 Topics: Adult; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Case-Control Studies; Cyanosis; Eisenmenger Complex; Endothelium, Vascular; Female; Heart Defects, Congenital; Humans; Male; Microcirculation; Middle Aged; Nitroglycerin; Oxidative Stress; Statistics, Nonparametric; Ultrasonography	2009
Nitroglycerin-induced preconditioning: interaction with nitrate tolerance. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:2 Topics: Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Endothelium, Vascular; Heme Oxygenase-1; Humans; Ischemic Preconditioning; Nitrates; Nitroglycerin; Reperfusion Injury; Vasodilator Agents	2010
Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate. The Journal of membrane biology, 2015, Volume: 248, Issue:2 Topics: Animals; Antioxidants; Ascorbic Acid; beta Carotene; Brain; Calcium; Calcium-Transporting ATPases; Disease Models, Animal; Enzyme Activation; Female; Glutathione; Glutathione Peroxidase; Headache; Lipid Peroxidation; Microsomes; Nitroglycerin; Oxidative Stress; Rats; Riboflavin; Vitamin A; Vitamin E	2015
The effect of vitamin C on nitroglycerin-mediated vasodilation in individuals with and without the aldehyde dehydrogenase 2 polymorphism. British journal of clinical pharmacology, 2023, Volume: 89, Issue:9 Topics: Aldehyde Dehydrogenase, Mitochondrial; Ascorbic Acid; Humans; Nitric Oxide; Nitroglycerin; Vasodilation; Vasodilator Agents; Vitamins	2023