Page last updated: 2024-09-03

nitroflurbiprofen and flurbiprofen

nitroflurbiprofen has been researched along with flurbiprofen in 56 studies

Compound Research Comparison

Studies (nitroflurbiprofen)	Trials (nitroflurbiprofen)	Recent Studies (post-2010) (nitroflurbiprofen)	Studies (flurbiprofen)	Trials (flurbiprofen)	Recent Studies (post-2010) (flurbiprofen)
58	1	6	2,072	466	575

Protein Interaction Comparison

Protein	Taxonomy	flurbiprofen (IC50)
Prostaglandin G/H synthase 1	Ovis aries (sheep)	0.1683
Prostaglandin G/H synthase 1	Homo sapiens (human)	0.6754
Prostaglandin G/H synthase 2	Homo sapiens (human)	0.574
Aldo-keto reductase family 1 member C3	Homo sapiens (human)	1.56
Prostaglandin G/H synthase 2	Mus musculus (house mouse)	0.5
Solute carrier family 22 member 6	Homo sapiens (human)	1.5
Prostaglandin G/H synthase 1	Rattus norvegicus (Norway rat)	0.17

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (17.86)	18.2507
2000's	38 (67.86)	29.6817
2010's	8 (14.29)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abdul-Hay, S; Qin, Z; Schiefer, IT; Thatcher, GR; Vanni, M; Wang, H	1
Baydoun, AR; Cicala, C; Cirino, G; Mancuso, F; Wallace, JL	1
Adami, A; Benoni, G; Cuzzolin, L; Del Soldato, P; Mariotto, S; Suzuki, H	1
Cicala, C; Cirino, G; Grisham, MB; McKnight, W; Reuter, B; Wallace, JL	1
Adami, A; Benoni, G; Carcereri de Prati, A; Cuzzolin, L; Mariotto, S; Menegazzi, M; Suzuki, H	1
Del Soldato, P; di Giamberardino, M; Padovano, R; Panara, MR; Patrignani, P; Rotondo, MT; Santini, G; Sciulli, MG	1
Bjarnason, I; Jacob, M; Macpherson, A; Mahmud, T; Price, AB; Rafi, S; Scott, D; Sherwood, R; Sigthorsson, G; Somasundaram, S; Wrigglesworth, JM	1
De Nucci, G; Donato, JL; Fujihara, CK; Malheiros, DM; Poli, A; Zatz, R	1
Hofer, M; Juchelková, L; Pipalová, I; Pospísil, M	1
Bertrand, V; Chaussade, S; Chauvelot-Moachon, L; Couturier, D; Giroud, JP; Guimbaud, R; Lamrani, A; Mauprivez, C; Sogni, P	1
Antonelli, E; Cirino, G; Coata, G; Distrutti, E; Federici, B; Fiorucci, S; Morelli, A; Morelli, O; Renzo, GD; Santucci, L; Soldato, PD	1
Hanson, PJ; Johal, K	1
Bertrand, V; Del Soldato, P; Lebrec, D; Lefilliatre, P; Moreau, R; Pateron, D; Sogni, P	1
Al-Swayeh, OA; Keeble, J; Moore, PK	1
Buchwald, SL; Moradi, WA	1
Armour, KE; Armour, KJ; Del Soldato, P; Ralston, SH; Torbergsen, AC; van 't Hof, RJ	1
Ajmone-Cat, MA; Minghetti, L; Nicolini, A	1
Cirino, G; del Soldato, P; Ialenti, A; Ianaro, A; Lippolis, L; Maffia, P; Maiello, FM; Sorrentino, R	1
Aldini, G; Carini, M; Facino, RM; Orioli, M; Wenk, GL	1
del Soldato, P; Ma, L; Wallace, JL	1
Hauss-Wegrzyniak, B; McGann, K; Rosi, S; Wenk, GL	2
Appleyard, RC; Del Soldato, P; Murrell, GA; Wang, MX; Wei, AQ; Yuan, J	1
Marshall, M; Moore, PK	1
Beckman, M	1
de Nucci, G; Fujihara, CK; Gonçalves, AR; Malheiros, DM; Mattar, AL; Noronha, Ide L; Zatz, R	1
Bergami, A; Brambilla, E; Butti, E; Comi, G; Furlan, R; Gasparini, L; Kurne, A; Martino, G; Maucci, R; Ongini, E	1
Butcher, C; Evans, CE	1
Scatena, R	1
Del Soldato, P; Idris, AI; Ralston, SH; van't Hof, RJ	1
Benjamin, N; Del Soldato, P; Donnellan, C; Forte, P; Johnston, A; O'Byrne, S; Vojnovic, I; Zacharowski, K; Zacharowski, P	1
Breese, E; Del Soldato, P; Mitchell, J; Warner, T; Wood, E; Zacharowski, P	1
Ajmone-Cat, MA; Bernardo, A; Gasparini, L; Minghetti, L; Ongini, E	1
Kadish, I; van Groen, T	1
Gasparini, L; Morgan, D; Ongini, E; Wilcock, D	1
Bhatia, M; Huang, J; Moochhala, SM; Moore, PK	1
Casagrande, S; Chiroli, V; Govoni, M; Maucci, R; Tocchetti, P	1
Anuar, F; Bhatia, M; Kwong, SE; Moore, PK; Siau, JL; Whiteman, M	1
Anuar, F; Bhatia, M; Moore, PK; Whiteman, M	1
Bottinelli, R; Brunelli, S; Clementi, E; Cossu, G; Covarello, D; D'Antona, G; Galvez, BG; Innocenzi, A; Monopoli, A; Ongini, E; Perrotta, C; Sanvito, F; Sciorati, C	1
Fevery, J; Laleman, W; Nevens, F; Van der Elst, I; Van Landeghem, L; Zeegers, M	1
Cilurzo, F; Minghetti, P; Montanari, L; Selmin, F; Vistoli, G	1
Astle, CM; Floyd, RA; Flurkey, K; Harrison, DE; Hensley, KL; Javors, MA; Leeuwenburgh, C; Miller, RA; Nadon, NL; Nelson, JF; Ongini, E; Strong, R; Warner, HR	2
Ji, H; Peng, SX; Zhang, YH	1
Idris, AI; Ralston, SH; van't Hof, RJ	1
Kedia, GT; Kuczyk, MA; Neumayer, E; Scheller, F; Uckert, S	1
Abdul-Hay, SO; Ashghodom, RT; Luo, J; Thatcher, GR	1
Abdul-Hay, SO; Edirisinghe, P; Thatcher, GR	1
Astle, CM; Flurkey, K; Harrison, DE	1
Caniglia, S; Impagnatiello, F; L'Episcopo, F; Marchetti, B; Morale, MC; Serra, PA; Testa, N; Tirolo, C	1
Kadish, I; Miettinen, P; van Groen, T	1
Caniglia, S; Impagnatiello, F; L'episcopo, F; Marchetti, B; Morale, MC; Testa, N; Tirolo, C	1
Ishiguro, T; Izumiya, M; Midorikawa, Y; Nakagama, H; Ohata, H; Okamoto, K; Sakai, H; Sato, A; Tsuchiya, N	1
De Nardi, C; Monopoli, A; Ongini, E; Thomas, GD; Victor, RG; Ye, J	1
Govoni, M; Lundberg, JO; Tocchetti, P	1

Reviews

3 review(s) available for nitroflurbiprofen and flurbiprofen

Article	Year
Nitroflurbiprofen (NicOx). Current opinion in investigational drugs (London, England : 2000), 2004, Volume: 5, Issue:5 Topics: Alzheimer Disease; Animals; Arthritis; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Flurbiprofen; Humans; Nitric Oxide Donors; Osteitis Deformans; Osteoporosis; Structure-Activity Relationship; Urinary Incontinence; Urticaria	2004
Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. Brain research. Brain research reviews, 2005, Volume: 48, Issue:2 Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Flurbiprofen; Humans; Inflammation; Microglia; Structure-Activity Relationship	2005
[A novel class of anti-inflammatory and analgesic drugs--NO-donating NSAIDs]. Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:4 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Cyclooxygenase Inhibitors; Flurbiprofen; Gastrointestinal Diseases; Humans; Ibuprofen; Naproxen; Nitrates; Nitric Oxide Donors	2007

Trials

1 trial(s) available for nitroflurbiprofen and flurbiprofen

Article	Year
The effects and metabolic fate of nitroflurbiprofen in healthy volunteers. Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:4 Topics: Administration, Oral; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Gastric Juice; Gastric Mucosa; Hemodynamics; Humans; Male; Nitric Oxide; Nitrogen Isotopes; Rats; Rats, Wistar; Stomach	2004

Article

Year

The effects and metabolic fate of nitroflurbiprofen in healthy volunteers.

Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:4

Topics: Administration, Oral; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Gastric Juice; Gastric Mucosa; Hemodynamics; Humans; Male; Nitric Oxide; Nitrogen Isotopes; Rats; Rats, Wistar; Stomach

2004

Other Studies

52 other study(ies) available for nitroflurbiprofen and flurbiprofen

Article	Year
Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7 Topics: Amyloid beta-Peptides; Amyloidosis; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Humans; Mice; Neurons; Nitrates; Small Molecule Libraries	2011
Flurbinitroxybutylester: a novel anti-inflammatory drug has enhanced antithrombotic activity. Thrombosis research, 1995, Jul-01, Volume: 79, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Drug Evaluation, Preclinical; Epinephrine; Fibrinolytic Agents; Flurbiprofen; Humans; Male; Mice; Molecular Structure; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thromboembolism	1995
Effect of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils. British journal of pharmacology, 1995, Volume: 115, Issue:2 Topics: Administration, Oral; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Separation; Centrifugation, Density Gradient; Enzyme Induction; Female; Flurbiprofen; Lipopolysaccharides; Neutrophils; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley	1995
Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology, 1994, Volume: 107, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Flurbiprofen; Ketoprofen; Leukocytes; Male; Nitrates; Nitrites; Nitrogen Oxides; Platelet Aggregation; Prostaglandins; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship	1994
Protective effect of NO on gastric lesions and inhibition of expression of gastric inducible NOS by flurbiprofen and its nitro-derivative, nitroflurbiprofen. British journal of pharmacology, 1995, Volume: 116, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Flurbiprofen; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach	1995
Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases. European journal of pharmacology, 1996, Nov-28, Volume: 316, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Dinoprostone; Drug Stability; Female; Flurbiprofen; Humans; Isoenzymes; Leukocytes, Mononuclear; Male; Middle Aged; Thromboxane B2	1996
Intestinal tolerability of nitroxybutyl-flurbiprofen in rats. Gut, 1997, Volume: 40, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Flurbiprofen; Intestine, Small; Male; Mitochondria, Liver; Oxidative Phosphorylation; Permeability; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms	1997
Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney. The American journal of physiology, 1998, Volume: 274, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Flurbiprofen; Glomerulosclerosis, Focal Segmental; Hemodynamics; Kidney; Male; Nephrectomy; Nitric Oxide; Rats; Rats, Wistar	1998
Radioprotective effects of flurbiprofen and its nitroderivative. Physiological research, 1998, Volume: 47, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Flurbiprofen; Granulocytes; Leukocyte Count; Lymphocyte Count; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Radiation-Protective Agents; Spleen; Survival Analysis; Time Factors	1998
Role of tumour necrosis factor-alpha and inducible nitric oxide synthase in the prevention of nitro-flurbiprofen small intestine toxicity. European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Intestine, Small; Male; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ulcer	1998
Nitric oxide-releasing NSAIDs inhibit interleukin-1beta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha. Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase Inhibitors; Cell Line; Cysteine Proteinase Inhibitors; DNA Fragmentation; Endothelium, Vascular; Flurbiprofen; Gastric Mucosa; Humans; In Situ Nick-End Labeling; Male; Mice; Naproxen; Nitric Oxide; Peroxidase; Rats; Rats, Wistar	1999
Opposite effects of flurbiprofen and the nitroxybutyl ester of flurbiprofen on apoptosis in cultured guinea-pig gastric mucous cells. British journal of pharmacology, 2000, Volume: 130, Issue:4 Topics: Acid Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspases; Cell Adhesion; Cell Extracts; Cells, Cultured; Ceramides; Cycloheximide; Dithiothreitol; Dose-Response Relationship, Drug; Enzyme Activation; Flurbiprofen; Gastric Mucosa; Guinea Pigs; Male; Nitric Oxide Donors; Penicillamine; Protein Synthesis Inhibitors; Proteins; Time Factors	2000
Aortic hyporeactivity to norepinephrine induced by lipopolysaccharide in cirrhotic rats: beneficial effects of a non-steroidal anti-inflammatory drug coupled with a nitric oxide donor. Journal of gastroenterology and hepatology, 2001, Volume: 16, Issue:1 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Flurbiprofen; Hemodynamics; Lipopolysaccharides; Liver Cirrhosis, Experimental; Male; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents	2001
Vasorelaxant effect of nitric oxide releasing steroidal and nonsteroidal anti-inflammatory drugs. British journal of pharmacology, 2001, Volume: 133, Issue:7 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Blood Pressure; Dose-Response Relationship, Drug; Flurbiprofen; In Vitro Techniques; Kidney; Male; Mesentery; Nitric Oxide; Nitroprusside; Prednisolone; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents	2001
Palladium-catalyzed alpha-arylation of esters. Journal of the American Chemical Society, 2001, Aug-22, Volume: 123, Issue:33 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Bromides; Catalysis; Esters; Flurbiprofen; Lithium; Molecular Structure; Naproxen; Organosilicon Compounds; Palladium; Phosphines	2001
Inhibition of bone resorption in vitro and prevention of ovariectomy-induced bone loss in vivo by flurbiprofen nitroxybutylester (HCT1026). Arthritis and rheumatism, 2001, Volume: 44, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Female; Flurbiprofen; In Vitro Techniques; Mice; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Ovariectomy; Spleen	2001
Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin E(2), interleukin-1beta, and nitric oxide synthesis by activated microglia. Journal of neuroscience research, 2001, Nov-15, Volume: 66, Issue:4 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cell Survival; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Encephalitis; Flurbiprofen; Interleukin-1; Lipopolysaccharides; Macrophages; Microglia; Neurodegenerative Diseases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Nitroso Compounds; Prostaglandin-Endoperoxide Synthases; Rats	2001
Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. Arteriosclerosis, thrombosis, and vascular biology, 2002, Feb-01, Volume: 22, Issue:2 Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Arteries; Coronary Restenosis; Dose-Response Relationship, Drug; Flurbiprofen; Hyperplasia; Immunohistochemistry; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Stomach Diseases; Tunica Intima	2002
Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: a LC-MS study. Life sciences, 2002, Aug-16, Volume: 71, Issue:13 Topics: Administration, Oral; Animals; Blood; Brain; Chromatography, High Pressure Liquid; Flurbiprofen; Male; Mass Spectrometry; Rats; Rats, Inbred F344; Reproducibility of Results	2002
Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. Proceedings of the National Academy of Sciences of the United States of America, 2002, Oct-01, Volume: 99, Issue:20 Topics: Animals; Apoptosis; Cell Division; Cells, Cultured; Collagen; Cyclooxygenase Inhibitors; Endostatins; Endothelial Growth Factors; Flurbiprofen; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Neovascularization, Pathologic; Nitric Oxide; Peptide Fragments; Rats; Rats, Wistar; Stomach; Thrombin; Time Factors; Ulcer; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002
A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat. European journal of pharmacology, 2002, Oct-25, Volume: 453, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Brain; Cholinesterase Inhibitors; Dentate Gyrus; Drug Therapy, Combination; Encephalitis; Flurbiprofen; Galantamine; Immunohistochemistry; Male; Microglia; Nitric Oxide Donors; Radioligand Assay; Rats; Rats, Inbred F344	2002
The influence of brain inflammation upon neuronal adenosine A2B receptors. Journal of neurochemistry, 2003, Volume: 86, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Disease Models, Animal; Encephalitis; Flurbiprofen; Immunohistochemistry; Lipopolysaccharides; Male; Microglia; Neurons; Nitric Oxide Donors; Rats; Rats, Inbred F344; Receptor, Adenosine A2B; Receptors, Purinergic P1; Second Messenger Systems	2003
Addition of nitric oxide via nitroflurbiprofen enhances the material properties of early healing of young rat Achilles tendons. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2003, Volume: 52, Issue:6 Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Body Water; Collagen; Coloring Agents; Extracellular Space; Flurbiprofen; Male; Nitric Oxide; Organ Size; Rats; Rats, Sprague-Dawley; Weight Gain; Wound Healing	2003
Effect of nitric oxide releasing paracetamol and flurbiprofen on cytokine production in human blood. European journal of pharmacology, 2004, Jan-12, Volume: 483, Issue:2-3 Topics: Acetaminophen; Cytokines; Flurbiprofen; Free Radical Scavengers; Humans; Nitrates; Nitric Oxide Donors	2004
Placing bets. National Institute on Aging committee chooses three compounds for definitive longevity testing. Science of aging knowledge environment : SAGE KE, 2004, Feb-04, Volume: 2004, Issue:5 Topics: Aging; Animals; Aspirin; Flurbiprofen; Longevity; Mice; National Institutes of Health (U.S.); United States	2004
Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. American journal of physiology. Renal physiology, 2004, Volume: 286, Issue:5 Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cyclooxygenase 2; Drug Therapy, Combination; Flurbiprofen; Hypertension, Renal; Immunohistochemistry; Isoenzymes; Kidney; Kidney Diseases; Losartan; Male; Nephrectomy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1	2004
A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 2004, Volume: 150, Issue:1-2 Topics: Administration, Oral; Adoptive Transfer; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4-Positive T-Lymphocytes; Cell Movement; Central Nervous System; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Epitopes, T-Lymphocyte; Female; Flurbiprofen; Glycoproteins; Growth Inhibitors; Immunosuppressive Agents; Interleukin-10; Lectins, C-Type; Lymphocyte Count; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin-Oligodendrocyte Glycoprotein; Nitric Oxide; Peptide Fragments; Receptors, Interleukin-2; RNA, Messenger; Spleen; T-Lymphocyte Subsets	2004
The influence on human osteoblasts in vitro of non-steroidal anti-inflammatory drugs which act on different cyclooxygenase enzymes. The Journal of bone and joint surgery. British volume, 2004, Volume: 86, Issue:3 Topics: Acetaminophen; Alkaline Phosphatase; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Count; Cells, Cultured; Collagen; Cyclooxygenase Inhibitors; DNA; Flurbiprofen; Furans; Humans; Indomethacin; Nitrates; Nitric Oxide; Nitric Oxide Donors; Osteoblasts; Prostaglandin-Endoperoxide Synthases	2004
The flurbiprofen derivatives HCT1026 and HCT1027 inhibit bone resorption by a mechanism independent of COX inhibition and nitric oxide production. Bone, 2004, Volume: 35, Issue:3 Topics: Animals; Bone Resorption; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Mice; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Rabbits	2004
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives. European journal of pharmacology, 2005, Jan-31, Volume: 508, Issue:1-3 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors	2005
Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen. Journal of neurochemistry, 2005, Volume: 92, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cerebral Cortex; Flurbiprofen; Microglia; PPAR gamma; Rats; Rats, Wistar	2005
Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology. Brain research. Brain research reviews, 2005, Volume: 48, Issue:2 Topics: Acetylcholinesterase; Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Butyrylcholinesterase; CD11b Antigen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Estrogens; Flurbiprofen; Fornix, Brain; Glial Fibrillary Acidic Protein; Hippocampus; Histocytochemistry; Inflammation; Male; Membrane Transport Proteins; Mice; Mice, Transgenic; Oligopeptides; Ovariectomy; Random Allocation; Vesicular Acetylcholine Transport Proteins	2005
Flurbiprofen and HCT1026 protect mice against acute pancreatitis-associated lung injury. Shock (Augusta, Ga.), 2005, Volume: 24, Issue:2 Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Gastric Mucosa; Inflammation; Lung; Lung Injury; Male; Mice; Neutrophils; Nitric Oxide; Pancreas; Pancreatitis; Peroxidase; Sepsis; Time Factors	2005
In vitro metabolism of (nitrooxy)butyl ester nitric oxide-releasing compounds: comparison with glyceryl trinitrate. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:2 Topics: Animals; Biotransformation; Butanes; Cytosol; Flurbiprofen; In Vitro Techniques; Liver; Male; Mitochondria, Liver; Molecular Structure; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Rats; Rats, Sprague-Dawley	2006
Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. British journal of pharmacology, 2006, Volume: 147, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cystathionine gamma-Lyase; Flurbiprofen; Hydrogen Sulfide; Interleukin-1beta; Kidney; Lipopolysaccharides; Liver; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Shock, Septic; Tumor Necrosis Factor-alpha	2006
Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cecum; Disease Models, Animal; Flurbiprofen; Interleukin-1beta; Ligation; Male; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Sprague-Dawley; Shock, Septic; Tumor Necrosis Factor-alpha	2006
Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy. Proceedings of the National Academy of Sciences of the United States of America, 2007, Jan-02, Volume: 104, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Combined Modality Therapy; Creatine Kinase; Flurbiprofen; Mice; Muscle, Skeletal; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Nitric Oxide Donors; Prednisolone; Regeneration; Sarcoglycans; Stem Cell Transplantation	2007
Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats. Gastroenterology, 2007, Volume: 132, Issue:2 Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Flurbiprofen; Hypertension, Portal; Kidney Diseases; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Male; Nitric Oxide; Nitric Oxide Donors; Peptic Ulcer; Perfusion; Portal Pressure; Rats; Rats, Wistar; Thioacetamide; Thromboxane A2; Vascular Resistance; Vasoconstriction; Vasodilation	2007
Binary polymeric blends to microencapsulate nitroflurbiprofen: physicochemical and in silico studies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 31, Issue:3-4 Topics: Acrylates; Algorithms; Calorimetry, Differential Scanning; Cyclooxygenase Inhibitors; Drug Carriers; Drug Compounding; Flurbiprofen; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Monte Carlo Method; Particle Size; Polymers; Povidone; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Transition Temperature; Viscosity; Water	2007
An Aging Interventions Testing Program: study design and interim report. Aging cell, 2007, Volume: 6, Issue:4 Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Cyclic N-Oxides; Drug Evaluation, Preclinical; Female; Flurbiprofen; Male; Masoprocol; Mice; Research Design; Survival Analysis	2007
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging cell, 2008, Volume: 7, Issue:5 Topics: Animals; Aspirin; Cyclic N-Oxides; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Free Radical Scavengers; Genetic Heterogeneity; Lipoxygenase Inhibitors; Longevity; Male; Masoprocol; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Random Allocation; Sex Characteristics; Survival Analysis	2008
The nitrosylated flurbiprofen derivative HCT1026 inhibits cytokine-induced signalling through a novel mechanism of action. European journal of pharmacology, 2009, Jan-14, Volume: 602, Issue:2-3 Topics: Actins; Animals; Apoptosis; Bone Resorption; Cytokines; Enzyme Activation; Flurbiprofen; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitroso Compounds; Osteoclasts; RANK Ligand; Signal Transduction	2009
[In vitro effects of a novel class of nitric oxide donating compounds on isolated human urinary bladder]. Georgian medical news, 2009, Issue:167 Topics: Anti-Infective Agents; Cyclic GMP; Flurbiprofen; Humans; In Vitro Techniques; Muscle, Smooth; Nitric Oxide; Urinary Bladder, Overactive	2009
NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade. Journal of neurochemistry, 2009, Volume: 111, Issue:3 Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Cell Line, Tumor; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flurbiprofen; Humans; Immunoprecipitation; Lipopolysaccharides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroblastoma; Neuroprotective Agents; Nitric Oxide Synthase Type II; Peptide Fragments; Prostaglandins; Rats; Rats, Long-Evans; Scopolamine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrazolium Salts; Thiazoles; Transfection	2009
Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels. Journal of neurochemistry, 2009, Volume: 111, Issue:3 Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fenofibrate; Flurbiprofen; Humans; Immunoprecipitation; Mice; Neuroblastoma; Peptide Fragments; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transfection	2009
Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. The journals of gerontology. Series A, Biological sciences and medical sciences, 2010, Volume: 65, Issue:12 Topics: Acetylcysteine; Animals; Aspirin; Crosses, Genetic; Diet; Female; Flurbiprofen; Imines; Life Expectancy; Longevity; Male; Masoprocol; Mice; Mice, Inbred Strains; Phenols; Sex Factors	2010
Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Journal of neuroinflammation, 2010, Nov-23, Volume: 7 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Flurbiprofen; Humans; Inflammation; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidoreductases; Parkinson Disease; Rotarod Performance Test; Substantia Nigra; Tyrosine	2010
Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathology. Journal of Alzheimer's disease : JAD, 2011, Volume: 24, Issue:2 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; CD11b Antigen; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Female; Flurbiprofen; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Presenilin-1	2011
Switching the microglial harmful phenotype promotes lifelong restoration of subtantia nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice. Rejuvenation research, 2011, Volume: 14, Issue:4 Topics: Aging; Animals; Dopaminergic Neurons; Flurbiprofen; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Nerve Regeneration; Nitrosation; Oxidative Stress; Phenotype; Real-Time Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase	2011
miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. The EMBO journal, 2012, Apr-04, Volume: 31, Issue:7 Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Flurbiprofen; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice; MicroRNAs; Receptor, IGF Type 1	2012
Treatment with a nitric oxide-donating NSAID alleviates functional muscle ischemia in the mouse model of Duchenne muscular dystrophy. PloS one, 2012, Volume: 7, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Disease Models, Animal; Feeding Behavior; Flurbiprofen; Hemodynamics; Hindlimb; Ischemia; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscles; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Nitric Oxide Donors; Norepinephrine; Time Factors; Vasoconstriction; Weight Gain	2012
Metabolism and pathways for denitration of organic nitrates in the human liver. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 346, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanes; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytosol; Enzyme Inhibitors; Female; Flurbiprofen; Free Radical Scavengers; Humans; Kinetics; Liver; Male; Metabolic Detoxication, Phase I; Microsomes, Liver; Mitochondria, Liver; Nitric Oxide; Nitro Compounds; Nitroglycerin; Vasodilator Agents	2013