Compounds > nitrobenzylthioinosine 5'-monophosphate
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nitrobenzylthioinosine 5'-monophosphate and trimetrexate

nitrobenzylthioinosine 5'-monophosphate has been researched along with trimetrexate in 6 studies

Compound Research Comparison

Studies
(nitrobenzylthioinosine 5'-monophosphate)		Trials
(nitrobenzylthioinosine 5'-monophosphate)		Recent Studies (post-2010)
(nitrobenzylthioinosine 5'-monophosphate)		Studies
(trimetrexate)		Trials
(trimetrexate)		Recent Studies (post-2010) (trimetrexate)
32014225021

Protein Interaction Comparison

ProteinTaxonomynitrobenzylthioinosine 5'-monophosphate (IC50)trimetrexate (IC50)
Dihydrofolate reductase Mycobacterium avium0.3012
Dihydrofolate reductaseHomo sapiens (human)0.0207
Dihydrofolate reductaseLacticaseibacillus casei0.1435
Dihydrofolate reductaseSaccharomyces cerevisiae S288C0.042
Dihydrofolate reductaseEscherichia coli K-120.1798
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.026
Dihydrofolate reductasePneumocystis carinii0.0378
Dihydrofolate reductaseCandida albicans0.04
Dipeptidyl peptidase 4Homo sapiens (human)0.01
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.008
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii0.5788
Bifunctional dihydrofolate reductase-thymidylate synthaseTrypanosoma cruzi0.0202
Dihydrofolate reductaseRattus norvegicus (Norway rat)0.0794

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allay, JA; Belt, JA; Blakley, RL; Sorrentino, BP; Spencer, HT; Wilkinson, SL1
Allay, JA; Ashmun, RA; Blakley, RL; Galipeau, J; Persons, DA; Riberdy, JM; Sorrentino, BP1
Allay, JA; Blakley, RL; Galipeau, J; Sorrentino, BP1
Diers, MD; McIvor, RS; Wagner, JE; Warlick, CA1
Frandsen, JL; McIvor, RS; Sweeney, CL; Verfaillie, CM1
Agricola, B; Allay, JA; Bonifacino, A; Donahue, RE; Dunbar, CE; Lu, T; Metzger, ME; Persons, DA; Sorrentino, BP1

Other Studies

6 other study(ies) available for nitrobenzylthioinosine 5'-monophosphate and trimetrexate

ArticleYear
Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors.
    Blood, 1997, Nov-01, Volume: 90, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Cell Death; Drug Resistance, Neoplasm; Female; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred C57BL; Thioinosine; Thionucleotides; Thymidine; Trimetrexate

1997
In vivo selection of retrovirally transduced hematopoietic stem cells.
    Nature medicine, 1998, Volume: 4, Issue:10

    Topics: Animals; Blood Cells; Drug Resistance; Female; Folic Acid Antagonists; Genes, Reporter; Genetic Therapy; Genetic Vectors; Hematopoietic Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Retroviridae; Selection, Genetic; Tetrahydrofolate Dehydrogenase; Thioinosine; Thionucleotides; Transformation, Genetic; Trimetrexate

1998
Retroviral vectors containing a variant dihydrofolate reductase gene for drug protection and in vivo selection of hematopoietic cells.
    Stem cells (Dayton, Ohio), 1998, Volume: 16 Suppl 1

    Topics: Adult; Amino Acid Substitution; Animals; Antigens, CD; Bone Marrow Cells; CD24 Antigen; Encephalomyocarditis virus; Female; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy; Genetic Variation; Genetic Vectors; Harvey murine sarcoma virus; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Membrane Glycoproteins; Mice; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Thioinosine; Thionucleotides; Transfection; Trimetrexate

1998
In vivo selection of antifolate-resistant transgenic hematopoietic stem cells in a murine bone marrow transplant model.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Animals; Blotting, Southern; Bone Marrow Transplantation; Female; Folic Acid Antagonists; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Leukocyte Count; Mice; Mice, Transgenic; Spleen; Tetrahydrofolate Dehydrogenase; Thioinosine; Thionucleotides; Trimetrexate

2002
Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase.
    Cancer research, 2003, Mar-15, Volume: 63, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Drug Synergism; Female; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred C3H; Mice, Transgenic; Tetrahydrofolate Dehydrogenase; Thioinosine; Thionucleotides; Trimetrexate

2003
Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors.
    Blood, 2004, Feb-01, Volume: 103, Issue:3

    Topics: Animals; Drug Combinations; Drug Resistance; Genetic Therapy; Genetic Vectors; Glucuronates; Green Fluorescent Proteins; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Luminescent Proteins; Macaca mulatta; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Thioinosine; Thionucleotides; Transduction, Genetic; Trimetrexate

2004