Page last updated: 2024-09-03

nitroaspirin and cyclic gmp

nitroaspirin has been researched along with cyclic gmp in 11 studies

Compound Research Comparison

Studies (nitroaspirin)	Trials (nitroaspirin)	Recent Studies (post-2010) (nitroaspirin)	Studies (cyclic gmp)	Trials (cyclic gmp)	Recent Studies (post-2010) (cyclic gmp)
127	9	8	22,346	333	4,062

Protein Interaction Comparison

Protein	Taxonomy	cyclic gmp (IC50)
Phosphodiesterase	Bos taurus (cattle)	0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	2.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Homo sapiens (human)	2.4

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (18.18)	18.2507
2000's	9 (81.82)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrioli, G; Bellavite, P; Benoni, G; Degan, M; Gaino, S; Lechi, A; Lechi, C; Minuz, P; Ortolani, R; Tommasoli, R; Zuliani, V	1
Antonelli, E; Del Soldato, P; Federici, B; Fiorucci, S; Mannucci, R; Miglietti, M; Morelli, A; Morelli, O; Santucci, L	1
Nakaki, T	1
Grosser, N; Schröder, H	1
Bernareggi, M; Berti, F; Colonna, VD; Manfredi, B; Rossoni, G	1
Degan, M; Gaino, S; Lechi, A; Meneguzzi, A; Minuz, P; Santonastaso, CL; Soldato, PD; Zuliani, V	1
Fiorucci, S; Ignarro, LJ; Wallace, JL	1
Berti, F; Del Soldato, P; Manfredi, B; Rossoni, G	1
Angelini, GD; Ascione, R; Capoun, R; Jeremy, JY; Shukla, N; Talpahewa, S	1
Berti, F; Del Soldato, P; Manfredi, B; Polvani, G; Rossoni, G	1
Breese, E; Del Soldato, P; Mitchell, J; Warner, T; Wood, E; Zacharowski, P	1

Reviews

2 review(s) available for nitroaspirin and cyclic gmp

Article	Year
[Nitic oxide and natriuretic peptides]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2000, Volume: 45, Issue:6 Suppl Topics: Adenylyl Cyclase Inhibitors; Aspirin; Cyclic GMP; Drug Design; Humans; Natriuretic Agents; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfhydryl Compounds; Sulfones	2000
Potential cardioprotective actions of no-releasing aspirin. Nature reviews. Drug discovery, 2002, Volume: 1, Issue:5 Topics: Animals; Apoptosis; Arteriosclerosis; Aspirin; Caspase Inhibitors; Cell Adhesion; Cyclic GMP; Cytokines; Heart; Humans; Hypertension; Myocardial Infarction; Stroke	2002

Article

Year

[Nitic oxide and natriuretic peptides].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2000, Volume: 45, Issue:6 Suppl

Topics: Adenylyl Cyclase Inhibitors; Aspirin; Cyclic GMP; Drug Design; Humans; Natriuretic Agents; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfhydryl Compounds; Sulfones

2000

Potential cardioprotective actions of no-releasing aspirin.

Nature reviews. Drug discovery, 2002, Volume: 1, Issue:5

Topics: Animals; Apoptosis; Arteriosclerosis; Aspirin; Caspase Inhibitors; Cell Adhesion; Cyclic GMP; Cytokines; Heart; Humans; Hypertension; Myocardial Infarction; Stroke

2002

Other Studies

9 other study(ies) available for nitroaspirin and cyclic gmp

Article	Year
The antiplatelet effects of a new nitroderivative of acetylsalicylic acid--an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production. Thrombosis and haemostasis, 1996, Volume: 76, Issue:5 Topics: Adult; Aspirin; Blood Platelets; Calcium; Cyclic GMP; Humans; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thromboxane A2	1996
Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats. Gastroenterology, 1999, Volume: 116, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase Inhibitors; Caspases; Cyclic GMP; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Gastric Mucosa; Humans; In Situ Nick-End Labeling; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Salicylates; Time Factors; Tumor Necrosis Factor-alpha; U937 Cells	1999
A common pathway for nitric oxide release from NO-aspirin and glyceryl trinitrate. Biochemical and biophysical research communications, 2000, Jul-21, Volume: 274, Issue:1 Topics: Animals; Aspirin; Cell Line; Cyclic GMP; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Epithelial Cells; Free Radical Scavengers; Imidazoles; Kidney; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Protein Binding; Swine	2000
The nitroderivative of aspirin, NCX 4016, reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Aspirin; Creatine Kinase; Cyclic GMP; Fibrinolytic Agents; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; NG-Nitroarginine Methyl Ester; Peroxidase; Platelet Aggregation Inhibitors; Rats; Rats, Wistar	2001
NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes. British journal of pharmacology, 2001, Volume: 134, Issue:4 Topics: Aspirin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolytic Agents; Guanylate Cyclase; Humans; Interleukin-6; Lipopolysaccharides; Monocytes; Nitric Oxide; Oxadiazoles; Quinoxalines; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha	2001
NCX 4016, a nitric oxide-releasing aspirin, modulates adrenergic vasoconstriction in the perfused rat tail artery. British journal of pharmacology, 2002, Volume: 137, Issue:2 Topics: Animals; Arteries; Aspirin; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Male; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Perfusion; Rats; Rats, Wistar; Tail; Vasoconstriction	2002
Nitric oxide donating aspirins: novel drugs for the treatment of saphenous vein graft failure. The Annals of thoracic surgery, 2003, Volume: 75, Issue:5 Topics: Aged; Aspirin; Cell Division; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Platelet Aggregation Inhibitors; Saphenous Vein; Vasodilation	2003
Nitric oxide-releasing aspirin inhibits vasoconstriction in perfused tail artery of normotensive and spontaneously hypertensive rats. European journal of pharmacology, 2003, Sep-05, Volume: 477, Issue:1 Topics: Animals; Arteries; Aspirin; Blood Pressure; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Nitrates; Nitric Oxide Donors; Nitrites; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tail; Thromboxane B2; Time Factors; Vasoconstriction	2003
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives. European journal of pharmacology, 2005, Jan-31, Volume: 508, Issue:1-3 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors	2005