nitroarginine and methyl-6-7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate

nitroarginine has been researched along with methyl-6-7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate* in 1 studies

Other Studies

1 other study(ies) available for nitroarginine and methyl-6-7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate

Article	Year
Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice. Life sciences, 1997, Volume: 60, Issue:23 The present study investigated the effects of nitric oxide synthase (NOS) inhibitors on the seizure threshold of DMCM in mice. The seizure threshold of DMCM was evaluated using an intravenous infusion technique. The threshold of DMCM was significantly decreased by pretreatment with N-nitro-L-arginine (NOARG; 8 mg/kg) and N-nitro-L-arginine methyl ester (L-NAME; 100 mg/kg), but not with D-NAME. Furthermore, these NOS inhibitors also decreased the threshold for pentylenetetrazole-induced seizure. However, the threshold for caffeine-induced seizure was not affected by NOARG. These results suggest that the endogenous NO system may play an important role in the expression of seizure by GABA(A) receptor inhibitory agents (DMCM and PTZ). Topics: Animals; Carbolines; Convulsants; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Seizures	1997

Article

Year

Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice.

Life sciences, 1997, Volume: 60, Issue:23

The present study investigated the effects of nitric oxide synthase (NOS) inhibitors on the seizure threshold of DMCM in mice. The seizure threshold of DMCM was evaluated using an intravenous infusion technique. The threshold of DMCM was significantly decreased by pretreatment with N-nitro-L-arginine (NOARG; 8 mg/kg) and N-nitro-L-arginine methyl ester (L-NAME; 100 mg/kg), but not with D-NAME. Furthermore, these NOS inhibitors also decreased the threshold for pentylenetetrazole-induced seizure. However, the threshold for caffeine-induced seizure was not affected by NOARG. These results suggest that the endogenous NO system may play an important role in the expression of seizure by GABA(A) receptor inhibitory agents (DMCM and PTZ).

Topics: Animals; Carbolines; Convulsants; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Seizures

1997