nitroarginine has been researched along with iodonium-thiophene* in 1 studies
1 other study(ies) available for nitroarginine and iodonium-thiophene
| Article | Year |
|---|---|
Reversal of in vitro lipopolysaccharide-induced suppression of contraction in rat aorta by NG-nitro-arginine, diphenyleneiodonium and di-2-thienyliodonium.
The effects of NG-nitro-L-arginine (L-NNA), D-NNA, diphenyleneiodonium and di-2-thienyliodonium on contraction were studied in endothelium-denuded rat aortic rings incubated for 4 h with lipopolysaccharide (10 mu g ml-1) or vehicle. Lipopolysaccharide reduced Emax and increased EC50 of the phenylephrine (10-9-10-5 M) curve. Addition of D-NNA (4, 6 x 10-4 M), L-NNA (1, 10 x 10-6 M) and diphenyleneiodonium (1, 3 x 10-7 M), but not di-2-thienyliodonium (10-7 M), increased Emax and reduced EC50 of the phenylephrine curve of lipopolysaccharide-incubated but not control rings. Therefore, D-NNA, L-NNA and diphenyleneiodonium, but not di-2-thienyliodonium, inhibit inducible NO synthase in vascular smooth muscles. Topics: Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Hypoglycemic Agents; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroarginine; Onium Compounds; Phenylephrine; Rats; Rats, Sprague-Dawley; Thiophenes | 1996 |