nitrites has been researched along with sapropterin in 54 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.85) | 18.7374 |
1990's | 26 (48.15) | 18.2507 |
2000's | 20 (37.04) | 29.6817 |
2010's | 7 (12.96) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Gross, SS; Levi, R | 1 |
Bult, H; Herman, AG; Jorens, PG; van Overveld, FJ; Vermeire, PA | 1 |
Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G | 1 |
Marletta, MA; Tayeh, MA | 1 |
Blau, N; Flury, G; Schaffner, A; Schneemann, M; Schoedon, G | 1 |
Bachus, KE; Dittman, WA; Mason, SN; McDonald, B; Misukonis, MA; Sauls, DL; Shami, PJ; Smith, GK; Weinberg, JB; Wood, ER | 1 |
Banba, N; Hattori, Y; Kasai, K; Manaka, K; Motohashi, S; Nakanishi, N; Shimoda, S | 1 |
Kim, YM; Lancaster, JR | 1 |
Billiar, TR; Bloomgarden, G; Davies, P; Di Silvio, M; Geller, DA; Hatakeyama, K; Kagamiyama, H; Nakayama, DK; Pitt, BR; Simmons, RL | 1 |
Billiar, TR; Loftus, M; Robbins, PD; Stuehr, DJ; Tzeng, E | 1 |
Buttery, L; Greenhalgh, RM; Hicks, RC; Higman, DJ; Powell, JT; Springall, DR; Strachan, AM | 1 |
Cañada, FJ; Lamas, S; Pérez-Sala, D; Saura, M | 1 |
Billiar, TR; Geller, DA; Pitt, BR; Robbins, PD; Shears, LL; Simmons, RL; Tzeng, E; Watkins, SC | 1 |
Kelly, RA; Simmons, WW; Smith, GK; Smith, TW; Ungureanu-Longrois, D | 1 |
D'Sa, C; Hahn, M; Hirayama, K; Kapatos, G; West, A; Zhu, M | 1 |
Hayashi, M; Hirahashi, J; Hishikawa, K; Marumo, T; Nakaki, T; Saruta, T; Suzuki, H; Yasumori, T | 1 |
Blau, N; Linscheid, P; Schaffner, A; Schneemann, M; Schoedon, G; Walter, R | 1 |
Garver, RI; Haddad, IY; Hong, J; Matalon, S; Sorscher, EJ; Tzeng, E | 1 |
Brand, MP; Heales, SJ; Lindley, KJ; Milla, PJ; Rolfe, VE | 1 |
Akimoto, K; Hattori, Y; Kasai, K; Nakanishi, N | 1 |
Fitzpatrick, LA; Katusic, ZS; Kullo, IJ; Milstien, S; O'Brien, T; Pompili, VJ; Schwartz, RS; Tsutsui, M | 1 |
Bryan, TW; Jinkins, PA; Milligan, SA; Prado, SC; Robbins, RA | 1 |
Kato, Y; Koshimura, K; Murakami, Y; Tanaka, J | 1 |
Mayer, B; Schmidt, K; Werner, ER; Werner-felmayer, G | 1 |
Bae, Y; Cho, S; Choi, HJ; Chu, CK; Du, J; Gal, J; Hwang, O; Joh, TH; Park, LC; Volpe, BT | 1 |
Brand, MP; Canevari, L; Clark, JB; Heales, SJ; Hyland, K; Land, JM | 1 |
Gross, SS; Hattori, Y; Kasai, K; Nakanishi, N | 1 |
Crawley, J; Dobbie, M; Marsh, K; Surtees, R; Waruiru, C | 1 |
Boucher, JL; Mansuy, D; Moali, C; Renodon-Corniere, A; Stuehr, DJ | 1 |
Blum, M; Chernichowski, T; Iaina, A; Levo, Y; Schwartz, D; Schwartz, IF; Wollman, Y | 1 |
Blau, N; Thöny, B; Zorzi, G | 1 |
Billiar, TR; Ha, KS; Hatakeyama, K; Kim, CK; Kim, PK; Kim, YM; Kwon, YG; Lee, KS; Lee, SJ; Na, HJ; Park, JH; Yoneyama, T | 1 |
Fujii, S; Igarashi, J; Kosaka, H; Yamamoto, A; Yoneyama, H; Zhang, L | 1 |
Ghosh, S; Mukherjee, S; Regulski, M; Sahoo, R; Sengupta, R; Stuehr, DJ; Tully, T | 1 |
Dikshit, M; Raghavan, SA; Sharma, P | 1 |
Edmondson, DE; Hurshman, AR; Krebs, C; Marletta, MA | 1 |
Kosaka, H; Kubota, Y; Nakai, K | 1 |
Archer, SL; Chrapko, WE; Jurasz, P; Lara, N; Le Mellédo, JM; Radomski, MW | 1 |
Hashikabe, Y; Hattori, Y; Kase, H; Nakanishi, N; Uchida, K | 1 |
Hiroi, T; Ishii, M; Kiuchi, Y; Shimizu, S; Wajima, T | 1 |
Brandacher, G; Maglione, M; Margreiter, R; Obrist, P; Schneeberger, S; Thoeni, G; Werner, ER; Werner-Felmayer, G; Wrulich, OA | 1 |
Champion, HC; Dugas, TR; Duranski, MR; Elrod, JW; Greer, JJ; Kevil, CG; Langston, W; Lefer, DJ; Tao, L | 1 |
Ding, QF; Hattori, Y; Hayashi, T; Iguchi, A; Miyazaki-Akita, A; Nomura, T; Shiraishi, H | 1 |
Banba, N; Hattori, Y; Iwata, C; Kamikawa, Y; Kasai, K; Monden, T; Satoh, H; Uchida, K; Wang, X | 1 |
Heales, SJ; Hyland, K; Lam, AA | 1 |
Emoto, N; Fukatsu, A; Hayashi, T; Hirata, K; Ikemoto, K; Kawashima, S; Nomura, T; Sasaki, N; Shinohara, M; Shiraki, R; Takaya, T; Takeda, M; Yamashita, T; Yokoyama, M | 1 |
Hamadate, N; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M | 1 |
Hamadate, N; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M; Tsutsui, M | 1 |
Chappell, MC; Chen, AF; Gallagher, PE; Lindsey, SH; Varagic, J; Yamaleyeva, LM; Zhang, LL | 1 |
Fung, HL; Mohan, S | 1 |
Imanishi, M; Kitabayashi, C; Konishi, Y; Maeda, I; Masada, M; Morikawa, T; Nishiyama, A; Okada, N; Shirahashi, N; Wilcox, CS | 1 |
Messina, LM; Tie, G; Yan, J | 1 |
Abad, E; Garcia-Dorado, D; Hernando, V; Inserte, J; Poncelas-Nozal, M; Vilardosa, Ú | 1 |
Bayatli, N; Gur, S; Kaya, E; Un, O; Yilmaz, D | 1 |
2 trial(s) available for nitrites and sapropterin
Article | Year |
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Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder.
Topics: Adolescent; Adult; Anxiety Disorders; Biopterins; Blood Platelets; Depressive Disorder, Major; Female; Humans; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Reference Values | 2004 |
Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressure; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Hemodynamics; Humans; Kidney; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Valine; Valsartan | 2013 |
52 other study(ies) available for nitrites and sapropterin
Article | Year |
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Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Biopterins; Cells, Cultured; Cytosol; Hypoxanthines; Interferon-gamma; Kinetics; Lipopolysaccharides; Male; Methotrexate; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen Consumption; Pteridines; Pterins; Rats; Rats, Inbred F344; Recombinant Proteins | 1992 |
Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Citrulline; Hypoxanthines; Interferon-gamma; Macrophages, Alveolar; Male; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Rats; Rats, Wistar; Recombinant Proteins | 1992 |
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.
Topics: Animals; Biopterins; Cells, Cultured; Cytokines; Fibroblasts; Interferon-gamma; Interleukin-1; Kinetics; Methotrexate; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Pteridines; Pterins; Recombinant Proteins; Skin; Sugar Acids; Tumor Necrosis Factor-alpha | 1990 |
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor.
Topics: Animals; Arginine; Biopterins; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Kinetics; Macrophages; NADP; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction | 1989 |
Nitric oxide production depends on preceding tetrahydrobiopterin synthesis by endothelial cells: selective suppression of induced nitric oxide production by sepiapterin reductase inhibitors.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cell Line; Cell Survival; Dicumarol; Endothelium, Vascular; Escherichia coli; Humans; Interferon-gamma; Kinetics; Lipopolysaccharides; Mice; Nitric Oxide; Nitrites; Phenprocoumon; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1994 |
Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Base Sequence; Biopterins; Cell Line; DNA Primers; Enzyme Induction; Gene Expression; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Monocytes; Nitrates; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; RNA, Messenger | 1995 |
Regulation of inducible nitric oxide production by cytokines in human thyrocytes in culture.
Topics: Amino Acid Oxidoreductases; Base Sequence; Biopterins; Cells, Cultured; Cytokines; GTP Cyclohydrolase; Humans; Interferon-gamma; Interleukin-1; Iodine; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Thyroid Gland; Tumor Necrosis Factor-alpha | 1995 |
Tetrahydrobiopterin-dependent nitrite oxidation to nitrate in isolated rat hepatocytes.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytosol; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1993 |
Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle.
Topics: Animals; Biopterins; Cells, Cultured; Cytokines; GTP Cyclohydrolase; Hypoxanthines; Intracellular Membranes; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.
Topics: 3T3 Cells; Animals; Biopterins; Blotting, Northern; Blotting, Western; Cytosol; Dose-Response Relationship, Drug; Enzyme Induction; Genetic Engineering; Genetic Vectors; Humans; Mice; Nitric Oxide Synthase; Nitrites; Protein Conformation; Pteridines; Pterins; Recombinant Proteins; Retroviridae | 1995 |
Smoking impairs the activity of endothelial nitric oxide synthase in saphenous vein.
Topics: Adult; Biopterins; Blotting, Western; Calcimycin; Cyclic GMP; Endothelins; Endothelium, Vascular; Female; Humans; Immunohistochemistry; Ionophores; Male; Microscopy, Electron, Scanning; Middle Aged; Nitric Oxide Synthase; Nitrites; Organ Culture Techniques; Saphenous Vein; Smoking; Vasodilation | 1996 |
Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells.
Topics: Arginine; Biopterins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Sugar Acids; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Vascular gene transfer of the human inducible nitric oxide synthase: characterization of activity and effects on myointimal hyperplasia.
Topics: Animals; Base Sequence; beta-Galactosidase; Biopterins; Cells, Cultured; DNA Primers; Endothelium, Vascular; Gene Expression; Genetic Vectors; Humans; Hyperplasia; Isoenzymes; Liver; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitrites; Organ Culture Techniques; Polymerase Chain Reaction; Pulmonary Artery; Rats; Recombinant Proteins; Retroviridae; Sheep; Swine; Transfection; Tunica Intima | 1996 |
Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport.
Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Biological Transport; Biopterins; Cells, Cultured; Cytokines; Dexamethasone; Gene Expression Regulation, Enzymologic; Glucocorticoids; GTP Cyclohydrolase; Interferon-gamma; Interleukin-1; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1996 |
Tetrahydrobiopterin biosynthesis in C6 glioma cells: induction of GTP cyclohydrolase I gene expression by lipopolysaccharide and cytokine treatment.
Topics: Animals; Astrocytes; Biopterins; Brain Neoplasms; Drug Synergism; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glioma; GTP Cyclohydrolase; Lipopolysaccharides; Mice; Neoplasm Proteins; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitrites; Rats; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
Endothelin-1 inhibits induction of nitric oxide synthase and GTP cyclohydrolase I in rat mesangial cells.
Topics: Animals; Antioxidants; Azepines; Biopterins; Blotting, Northern; Blotting, Western; Cells, Cultured; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Induction; Glomerular Mesangium; GTP Cyclohydrolase; Male; Nitric Oxide Synthase; Nitrites; Oligopeptides; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Nitrite generation in interleukin-4-treated human macrophage cultures does not involve the nitric oxide synthase pathway.
Topics: Amino Acids; Animals; Arginine; Biopterins; Cells, Cultured; Culture Media; Female; Humans; Interferon-gamma; Interleukin-4; Macrophages; Male; Muscle, Smooth, Vascular; Neopterin; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Rats; Recombinant Proteins | 1997 |
Modulation of adenovirus-mediated gene transfer by nitric oxide.
Topics: 3T3 Cells; Adenoviruses, Human; Animals; Antioxidants; beta-Galactosidase; Biopterins; Cell Survival; Cyclic GMP; Enzyme Inhibitors; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Humans; Luciferases; Lung; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Pteridines; Pterins; Transfection | 1997 |
Tetrahydrobiopterin regulates cyclic GMP-dependent electrogenic Cl- secretion in mouse ileum in vitro.
Topics: Animals; Antioxidants; Arginine; Biopterins; Carbachol; Chloride Channels; Cholinergic Agonists; Cyclic GMP; Ileum; In Vitro Techniques; Intestinal Mucosa; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Muscle, Smooth; Nitric Oxide; Nitrites; Time Factors | 1997 |
Glucocorticoid regulation of nitric oxide and tetrahydrobiopterin in a rat model of endotoxic shock.
Topics: Adrenalectomy; Animals; Biopterins; Dexamethasone; Disease Models, Animal; Enzyme Induction; Escherichia coli; Glucocorticoids; GTP Cyclohydrolase; Hypotension; Kinetics; Lipopolysaccharides; Lung; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; RNA, Messenger; Shock, Septic; Transcription, Genetic | 1997 |
Expression and function of recombinant endothelial NO synthase in coronary artery smooth muscle cells.
Topics: Adenoviridae; Animals; Biopterins; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Cyclic GMP; DNA Replication; Enzyme Induction; Genes, Reporter; Genetic Vectors; GTP Cyclohydrolase; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Recombinant Fusion Proteins; Superoxide Dismutase; Swine; Transfection | 1997 |
Methotrexate inhibition of inducible nitric oxide synthase in murine lung epithelial cells in vitro.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biopterins; Blotting, Western; Cells, Cultured; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Epithelial Cells; Lung; Methotrexate; Mice; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger | 1998 |
Self-protection of PC12 cells by 6R-tetrahydrobiopterin from nitric oxide toxicity.
Topics: Animals; Biopterins; GTP Cyclohydrolase; Hypoxanthine; Neoplasm Proteins; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Nitroprusside; Oxidation-Reduction; PC12 Cells; Rats; Sugar Acids; Superoxides; Xanthine Oxidase | 1998 |
Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin.
Topics: Animals; Biopterins; Cytokines; Endothelium, Vascular; Enzyme Inhibitors; Fibroblasts; Humans; Mice; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Phenylalanine Hydroxylase; Swine; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1999 |
Blockade of tetrahydrobiopterin synthesis protects neurons after transient forebrain ischemia in rat: a novel role for the cofactor.
Topics: Animals; Biopterins; Brain; Caspase 3; Caspases; Dopamine; GTP Cyclohydrolase; Hippocampus; Ischemic Attack, Transient; Male; Mice; Microglia; NADPH Dehydrogenase; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Prosencephalon; Rats; Rats, Wistar; RNA, Messenger | 1999 |
Cerebrospinal fluid nitrite plus nitrate correlates with tetrahydrobiopterin concentration.
Topics: Adolescent; Biopterins; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Nitrates; Nitrites | 1999 |
Adrenomedullin augments nitric oxide and tetrahydrobioptein synthesis in cytokine-stimulated vascular smooth muscle cells.
Topics: Adrenomedullin; Analysis of Variance; Animals; Antioxidants; Biopterins; Cells, Cultured; Enzyme Activation; Gene Expression; GTP Cyclohydrolase; Interleukin-1; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peptides; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Rats, Wistar; RNA, Messenger; Shock, Septic; Vasodilator Agents | 1999 |
Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?
Topics: Antimalarials; Biopterins; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Endothelium; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyindoleacetic Acid; Infant; Kenya; Malaria, Cerebral; Microglia; Neopterin; Nitrates; Nitrites; Quinolinic Acid; Tryptophan | 2000 |
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.
Topics: Antioxidants; Arginine; Biopterins; Guanidines; Hydroxylamines; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Substrate Specificity; Superoxide Dismutase | 2001 |
Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA.
Topics: Amino Acid Transport Systems, Basic; Animals; Antioxidants; Arginine; Biological Transport; Biopterins; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Extracellular Space; Gene Expression Regulation; Lipopolysaccharides; Membrane Proteins; Myocardium; Nitrites; Protein Isoforms; Rats; Rats, Wistar; RNA, Messenger | 2001 |
Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency.
Topics: Adolescent; Adult; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Humans; Infant; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Phenylketonurias; Phosphorus-Oxygen Lyases | 2002 |
Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization.
Topics: Animals; Biopterins; Blotting, Northern; Blotting, Western; Cells, Cultured; Cyclic GMP; Cytokines; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; GTP Cyclohydrolase; Hepatocytes; Humans; Male; Muscle, Smooth; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Penicillamine; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors; Transfection | 2002 |
Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine.
Topics: Animals; Arginine; Biopterins; Gene Expression Regulation; Kidney; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Receptors, LDL; Receptors, Oxidized LDL; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class E; Superoxide Dismutase; Time Factors | 2003 |
Characterization of Drosophila nitric oxide synthase: a biochemical study.
Topics: Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Drosophila; Electrons; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Hydrogen Peroxide; Hydrolysis; NADP; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Open Reading Frames; Protein Structure, Tertiary; Spectrophotometry; Time Factors; Trypsin; Ultraviolet Rays; Urea | 2003 |
Role of ascorbate in the regulation of nitric oxide generation by polymorphonuclear leukocytes.
Topics: Animals; Ascorbic Acid; Biopterins; Blood Platelets; Citrulline; Dehydroascorbic Acid; Flow Cytometry; Haplorhini; Humans; Iodoacetamide; Male; Neutrophils; Nitric Oxide; Nitrites; Oxidation-Reduction; Oxygen; Rats; Rats, Sprague-Dawley | 2003 |
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.
Topics: Amino Acids; Arginine; Binding Sites; Biopterins; Catalysis; Dithionite; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Freezing; Heme; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxyhemoglobins; Protein Structure, Tertiary; Pterins; Recombinant Proteins; Time Factors | 2003 |
Inhibition of nuclear factor kappa B activation and inducible nitric oxide synthase transcription by prolonged exposure to high glucose in the human keratinocyte cell line HaCaT.
Topics: Antioxidants; Biopterins; Cell Line; Cytokines; DNA; Down-Regulation; Glucose; Humans; Keratinocytes; Lipopolysaccharides; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger; Time Factors; Transcription, Genetic | 2004 |
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Time Factors; Tyrosine; Up-Regulation | 2005 |
Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production.
Topics: Animals; Anti-Arrhythmia Agents; Arginine; Biopterins; Cyclic GMP; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxy Acids; Male; Malondialdehyde; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Potassium Channels; Rats; Rats, Sprague-Dawley | 2006 |
Tetrahydrobiopterin compounds prolong allograft survival independently of their effect on nitric oxide synthase activity.
Topics: Animals; Biopterins; Graft Survival; Heart Transplantation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase; Nitrites; Transplantation, Homologous | 2006 |
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.
Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Drug Synergism; Genetic Therapy; Liver; Metalloporphyrins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitrites; Phenotype; Phosphorylation; Pterins; Reperfusion Injury; Severity of Illness Index; Tyrosine | 2006 |
17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease.
Topics: Animals; Biopterins; Cardiovascular Diseases; Cattle; Cells, Cultured; Diabetes Complications; Down-Regulation; Endothelial Cells; Estradiol; Estrogen Receptor alpha; Female; GTP Cyclohydrolase; Hyperglycemia; Nitric Oxide Synthase Type III; Nitrites; Postmenopause; Protein Kinase C; RNA, Small Interfering | 2007 |
Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats.
Topics: Adiponectin; Adipose Tissue; Animals; Aorta, Thoracic; Biopterins; Blood Pressure; Endothelium, Vascular; Fructose; Male; Metabolic Syndrome; Myocardium; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides; Vasodilation | 2007 |
Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states.
Topics: Animals; Biological Availability; Biopterins; Brain; Carrier Proteins; Glutathione; GTP Cyclohydrolase; Kidney; Lipopolysaccharides; Liver; Metabolism, Inborn Errors; Mice; Mutation; Nitrates; Nitric Oxide; Nitrites; Osmolar Concentration; Polycomb Repressive Complex 1 | 2007 |
Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus.
Topics: Animals; Aorta; Biopterins; Carotid Arteries; Cholesterol; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; GTP Cyclohydrolase; Lung; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Streptozocin; Superoxides | 2008 |
Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats.
Topics: Acetylcholine; Anesthesia, General; Animals; Aorta, Thoracic; Biopterins; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; GTP Cyclohydrolase; Hypoxanthines; Male; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroprusside; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2008 |
Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Biopterins; Dietary Supplements; Endothelium, Vascular; Hemodynamics; Hypertension; In Vitro Techniques; Infusions, Intravenous; Male; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2010 |
Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat.
Topics: Animals; Biopterins; Blood Pressure; Female; Gene Expression Regulation; Hypertension; Inflammation; Kidney; Kidney Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Ornithine; Oxidative Stress; Rats; Rats, Inbred Lew; Renin; RNA, Messenger; Sodium Chloride, Dietary | 2012 |
Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine.
Topics: Arginine; Biopterins; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Lysine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress | 2012 |
Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat.
Topics: Administration, Oral; Animals; Arginine; Ascorbic Acid; Biopterins; Calcium; Drug Synergism; Hindlimb; Ischemia; Male; Models, Biological; Muscles; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Recovery of Function; Regional Blood Flow | 2012 |
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling.
Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Tyrosine | 2013 |
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
Topics: Aging; Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Erectile Dysfunction; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Penile Erection; Penis; Rats, Wistar; Sodium Nitrite | 2014 |