nitrites and sapropterin

nitrites has been researched along with sapropterin in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.85)	18.7374
1990's	26 (48.15)	18.2507
2000's	20 (37.04)	29.6817
2010's	7 (12.96)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gross, SS; Levi, R	1
Bult, H; Herman, AG; Jorens, PG; van Overveld, FJ; Vermeire, PA	1
Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G	1
Marletta, MA; Tayeh, MA	1
Blau, N; Flury, G; Schaffner, A; Schneemann, M; Schoedon, G	1
Bachus, KE; Dittman, WA; Mason, SN; McDonald, B; Misukonis, MA; Sauls, DL; Shami, PJ; Smith, GK; Weinberg, JB; Wood, ER	1
Banba, N; Hattori, Y; Kasai, K; Manaka, K; Motohashi, S; Nakanishi, N; Shimoda, S	1
Kim, YM; Lancaster, JR	1
Billiar, TR; Bloomgarden, G; Davies, P; Di Silvio, M; Geller, DA; Hatakeyama, K; Kagamiyama, H; Nakayama, DK; Pitt, BR; Simmons, RL	1
Billiar, TR; Loftus, M; Robbins, PD; Stuehr, DJ; Tzeng, E	1
Buttery, L; Greenhalgh, RM; Hicks, RC; Higman, DJ; Powell, JT; Springall, DR; Strachan, AM	1
Cañada, FJ; Lamas, S; Pérez-Sala, D; Saura, M	1
Billiar, TR; Geller, DA; Pitt, BR; Robbins, PD; Shears, LL; Simmons, RL; Tzeng, E; Watkins, SC	1
Kelly, RA; Simmons, WW; Smith, GK; Smith, TW; Ungureanu-Longrois, D	1
D'Sa, C; Hahn, M; Hirayama, K; Kapatos, G; West, A; Zhu, M	1
Hayashi, M; Hirahashi, J; Hishikawa, K; Marumo, T; Nakaki, T; Saruta, T; Suzuki, H; Yasumori, T	1
Blau, N; Linscheid, P; Schaffner, A; Schneemann, M; Schoedon, G; Walter, R	1
Garver, RI; Haddad, IY; Hong, J; Matalon, S; Sorscher, EJ; Tzeng, E	1
Brand, MP; Heales, SJ; Lindley, KJ; Milla, PJ; Rolfe, VE	1
Akimoto, K; Hattori, Y; Kasai, K; Nakanishi, N	1
Fitzpatrick, LA; Katusic, ZS; Kullo, IJ; Milstien, S; O'Brien, T; Pompili, VJ; Schwartz, RS; Tsutsui, M	1
Bryan, TW; Jinkins, PA; Milligan, SA; Prado, SC; Robbins, RA	1
Kato, Y; Koshimura, K; Murakami, Y; Tanaka, J	1
Mayer, B; Schmidt, K; Werner, ER; Werner-felmayer, G	1
Bae, Y; Cho, S; Choi, HJ; Chu, CK; Du, J; Gal, J; Hwang, O; Joh, TH; Park, LC; Volpe, BT	1
Brand, MP; Canevari, L; Clark, JB; Heales, SJ; Hyland, K; Land, JM	1
Gross, SS; Hattori, Y; Kasai, K; Nakanishi, N	1
Crawley, J; Dobbie, M; Marsh, K; Surtees, R; Waruiru, C	1
Boucher, JL; Mansuy, D; Moali, C; Renodon-Corniere, A; Stuehr, DJ	1
Blum, M; Chernichowski, T; Iaina, A; Levo, Y; Schwartz, D; Schwartz, IF; Wollman, Y	1
Blau, N; Thöny, B; Zorzi, G	1
Billiar, TR; Ha, KS; Hatakeyama, K; Kim, CK; Kim, PK; Kim, YM; Kwon, YG; Lee, KS; Lee, SJ; Na, HJ; Park, JH; Yoneyama, T	1
Fujii, S; Igarashi, J; Kosaka, H; Yamamoto, A; Yoneyama, H; Zhang, L	1
Ghosh, S; Mukherjee, S; Regulski, M; Sahoo, R; Sengupta, R; Stuehr, DJ; Tully, T	1
Dikshit, M; Raghavan, SA; Sharma, P	1
Edmondson, DE; Hurshman, AR; Krebs, C; Marletta, MA	1
Kosaka, H; Kubota, Y; Nakai, K	1
Archer, SL; Chrapko, WE; Jurasz, P; Lara, N; Le Mellédo, JM; Radomski, MW	1
Hashikabe, Y; Hattori, Y; Kase, H; Nakanishi, N; Uchida, K	1
Hiroi, T; Ishii, M; Kiuchi, Y; Shimizu, S; Wajima, T	1
Brandacher, G; Maglione, M; Margreiter, R; Obrist, P; Schneeberger, S; Thoeni, G; Werner, ER; Werner-Felmayer, G; Wrulich, OA	1
Champion, HC; Dugas, TR; Duranski, MR; Elrod, JW; Greer, JJ; Kevil, CG; Langston, W; Lefer, DJ; Tao, L	1
Ding, QF; Hattori, Y; Hayashi, T; Iguchi, A; Miyazaki-Akita, A; Nomura, T; Shiraishi, H	1
Banba, N; Hattori, Y; Iwata, C; Kamikawa, Y; Kasai, K; Monden, T; Satoh, H; Uchida, K; Wang, X	1
Heales, SJ; Hyland, K; Lam, AA	1
Emoto, N; Fukatsu, A; Hayashi, T; Hirata, K; Ikemoto, K; Kawashima, S; Nomura, T; Sasaki, N; Shinohara, M; Shiraki, R; Takaya, T; Takeda, M; Yamashita, T; Yokoyama, M	1
Hamadate, N; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M	1
Hamadate, N; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M; Tsutsui, M	1
Chappell, MC; Chen, AF; Gallagher, PE; Lindsey, SH; Varagic, J; Yamaleyeva, LM; Zhang, LL	1
Fung, HL; Mohan, S	1
Imanishi, M; Kitabayashi, C; Konishi, Y; Maeda, I; Masada, M; Morikawa, T; Nishiyama, A; Okada, N; Shirahashi, N; Wilcox, CS	1
Messina, LM; Tie, G; Yan, J	1
Abad, E; Garcia-Dorado, D; Hernando, V; Inserte, J; Poncelas-Nozal, M; Vilardosa, Ú	1
Bayatli, N; Gur, S; Kaya, E; Un, O; Yilmaz, D	1

Trials

2 trial(s) available for nitrites and sapropterin

Article	Year
Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder. Biological psychiatry, 2004, Jul-15, Volume: 56, Issue:2 Topics: Adolescent; Adult; Anxiety Disorders; Biopterins; Blood Platelets; Depressive Disorder, Major; Female; Humans; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Reference Values	2004
Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1 Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressure; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Hemodynamics; Humans; Kidney; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Valine; Valsartan	2013

Article

Year

Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder.

Biological psychiatry, 2004, Jul-15, Volume: 56, Issue:2

Topics: Adolescent; Adult; Anxiety Disorders; Biopterins; Blood Platelets; Depressive Disorder, Major; Female; Humans; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Reference Values

2004

Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.

Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1

Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressure; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Hemodynamics; Humans; Kidney; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Valine; Valsartan

2013

Other Studies

52 other study(ies) available for nitrites and sapropterin

Article	Year
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. The Journal of biological chemistry, 1992, Dec-25, Volume: 267, Issue:36 Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Biopterins; Cells, Cultured; Cytosol; Hypoxanthines; Interferon-gamma; Kinetics; Lipopolysaccharides; Male; Methotrexate; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen Consumption; Pteridines; Pterins; Rats; Rats, Inbred F344; Recombinant Proteins	1992
Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages. British journal of pharmacology, 1992, Volume: 107, Issue:4 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Citrulline; Hypoxanthines; Interferon-gamma; Macrophages, Alveolar; Male; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Rats; Rats, Wistar; Recombinant Proteins	1992
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. The Journal of experimental medicine, 1990, Dec-01, Volume: 172, Issue:6 Topics: Animals; Biopterins; Cells, Cultured; Cytokines; Fibroblasts; Interferon-gamma; Interleukin-1; Kinetics; Methotrexate; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Pteridines; Pterins; Recombinant Proteins; Skin; Sugar Acids; Tumor Necrosis Factor-alpha	1990
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. The Journal of biological chemistry, 1989, Nov-25, Volume: 264, Issue:33 Topics: Animals; Arginine; Biopterins; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Kinetics; Macrophages; NADP; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction	1989
Nitric oxide production depends on preceding tetrahydrobiopterin synthesis by endothelial cells: selective suppression of induced nitric oxide production by sepiapterin reductase inhibitors. Biochemical and biophysical research communications, 1994, Mar-15, Volume: 199, Issue:2 Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cell Line; Cell Survival; Dicumarol; Endothelium, Vascular; Escherichia coli; Humans; Interferon-gamma; Kinetics; Lipopolysaccharides; Mice; Nitric Oxide; Nitrites; Phenprocoumon; Recombinant Proteins; Tumor Necrosis Factor-alpha	1994
Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. Blood, 1995, Aug-01, Volume: 86, Issue:3 Topics: Amino Acid Oxidoreductases; Animals; Base Sequence; Biopterins; Cell Line; DNA Primers; Enzyme Induction; Gene Expression; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Monocytes; Nitrates; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; RNA, Messenger	1995
Regulation of inducible nitric oxide production by cytokines in human thyrocytes in culture. Endocrinology, 1995, Volume: 136, Issue:10 Topics: Amino Acid Oxidoreductases; Base Sequence; Biopterins; Cells, Cultured; Cytokines; GTP Cyclohydrolase; Humans; Interferon-gamma; Interleukin-1; Iodine; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Thyroid Gland; Tumor Necrosis Factor-alpha	1995
Tetrahydrobiopterin-dependent nitrite oxidation to nitrate in isolated rat hepatocytes. FEBS letters, 1993, Oct-18, Volume: 332, Issue:3 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytosol; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tumor Necrosis Factor-alpha	1993
Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. The American journal of physiology, 1994, Volume: 266, Issue:4 Pt 1 Topics: Animals; Biopterins; Cells, Cultured; Cytokines; GTP Cyclohydrolase; Hypoxanthines; Intracellular Membranes; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger	1994
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. Proceedings of the National Academy of Sciences of the United States of America, 1995, Dec-05, Volume: 92, Issue:25 Topics: 3T3 Cells; Animals; Biopterins; Blotting, Northern; Blotting, Western; Cytosol; Dose-Response Relationship, Drug; Enzyme Induction; Genetic Engineering; Genetic Vectors; Humans; Mice; Nitric Oxide Synthase; Nitrites; Protein Conformation; Pteridines; Pterins; Recombinant Proteins; Retroviridae	1995
Smoking impairs the activity of endothelial nitric oxide synthase in saphenous vein. Arteriosclerosis, thrombosis, and vascular biology, 1996, Volume: 16, Issue:4 Topics: Adult; Biopterins; Blotting, Western; Calcimycin; Cyclic GMP; Endothelins; Endothelium, Vascular; Female; Humans; Immunohistochemistry; Ionophores; Male; Microscopy, Electron, Scanning; Middle Aged; Nitric Oxide Synthase; Nitrites; Organ Culture Techniques; Saphenous Vein; Smoking; Vasodilation	1996
Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells. The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24 Topics: Arginine; Biopterins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Sugar Acids; Transcription, Genetic; Tumor Necrosis Factor-alpha	1996
Vascular gene transfer of the human inducible nitric oxide synthase: characterization of activity and effects on myointimal hyperplasia. Molecular medicine (Cambridge, Mass.), 1996, Volume: 2, Issue:2 Topics: Animals; Base Sequence; beta-Galactosidase; Biopterins; Cells, Cultured; DNA Primers; Endothelium, Vascular; Gene Expression; Genetic Vectors; Humans; Hyperplasia; Isoenzymes; Liver; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitrites; Organ Culture Techniques; Polymerase Chain Reaction; Pulmonary Artery; Rats; Recombinant Proteins; Retroviridae; Sheep; Swine; Transfection; Tunica Intima	1996
Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport. The Journal of biological chemistry, 1996, Sep-27, Volume: 271, Issue:39 Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Biological Transport; Biopterins; Cells, Cultured; Cytokines; Dexamethasone; Gene Expression Regulation, Enzymologic; Glucocorticoids; GTP Cyclohydrolase; Interferon-gamma; Interleukin-1; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Recombinant Proteins	1996
Tetrahydrobiopterin biosynthesis in C6 glioma cells: induction of GTP cyclohydrolase I gene expression by lipopolysaccharide and cytokine treatment. Brain research. Molecular brain research, 1996, Sep-05, Volume: 41, Issue:1-2 Topics: Animals; Astrocytes; Biopterins; Brain Neoplasms; Drug Synergism; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glioma; GTP Cyclohydrolase; Lipopolysaccharides; Mice; Neoplasm Proteins; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitrites; Rats; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1996
Endothelin-1 inhibits induction of nitric oxide synthase and GTP cyclohydrolase I in rat mesangial cells. Pharmacology, 1996, Volume: 53, Issue:4 Topics: Animals; Antioxidants; Azepines; Biopterins; Blotting, Northern; Blotting, Western; Cells, Cultured; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Induction; Glomerular Mesangium; GTP Cyclohydrolase; Male; Nitric Oxide Synthase; Nitrites; Oligopeptides; Rats; Rats, Sprague-Dawley; RNA, Messenger	1996
Nitrite generation in interleukin-4-treated human macrophage cultures does not involve the nitric oxide synthase pathway. The Journal of infectious diseases, 1997, Volume: 175, Issue:1 Topics: Amino Acids; Animals; Arginine; Biopterins; Cells, Cultured; Culture Media; Female; Humans; Interferon-gamma; Interleukin-4; Macrophages; Male; Muscle, Smooth, Vascular; Neopterin; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Rats; Recombinant Proteins	1997
Modulation of adenovirus-mediated gene transfer by nitric oxide. American journal of respiratory cell and molecular biology, 1997, Volume: 16, Issue:5 Topics: 3T3 Cells; Adenoviruses, Human; Animals; Antioxidants; beta-Galactosidase; Biopterins; Cell Survival; Cyclic GMP; Enzyme Inhibitors; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Humans; Luciferases; Lung; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Pteridines; Pterins; Transfection	1997
Tetrahydrobiopterin regulates cyclic GMP-dependent electrogenic Cl- secretion in mouse ileum in vitro. The Journal of physiology, 1997, Sep-01, Volume: 503 ( Pt 2) Topics: Animals; Antioxidants; Arginine; Biopterins; Carbachol; Chloride Channels; Cholinergic Agonists; Cyclic GMP; Ileum; In Vitro Techniques; Intestinal Mucosa; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Muscle, Smooth; Nitric Oxide; Nitrites; Time Factors	1997
Glucocorticoid regulation of nitric oxide and tetrahydrobiopterin in a rat model of endotoxic shock. Biochemical and biophysical research communications, 1997, Nov-17, Volume: 240, Issue:2 Topics: Adrenalectomy; Animals; Biopterins; Dexamethasone; Disease Models, Animal; Enzyme Induction; Escherichia coli; Glucocorticoids; GTP Cyclohydrolase; Hypotension; Kinetics; Lipopolysaccharides; Lung; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; RNA, Messenger; Shock, Septic; Transcription, Genetic	1997
Expression and function of recombinant endothelial NO synthase in coronary artery smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:11 Topics: Adenoviridae; Animals; Biopterins; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Cyclic GMP; DNA Replication; Enzyme Induction; Genes, Reporter; Genetic Vectors; GTP Cyclohydrolase; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Recombinant Fusion Proteins; Superoxide Dismutase; Swine; Transfection	1997
Methotrexate inhibition of inducible nitric oxide synthase in murine lung epithelial cells in vitro. American journal of respiratory cell and molecular biology, 1998, Volume: 18, Issue:6 Topics: Animals; Antineoplastic Agents; Antioxidants; Biopterins; Blotting, Western; Cells, Cultured; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Epithelial Cells; Lung; Methotrexate; Mice; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger	1998
Self-protection of PC12 cells by 6R-tetrahydrobiopterin from nitric oxide toxicity. Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5 Topics: Animals; Biopterins; GTP Cyclohydrolase; Hypoxanthine; Neoplasm Proteins; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Nitroprusside; Oxidation-Reduction; PC12 Cells; Rats; Sugar Acids; Superoxides; Xanthine Oxidase	1998
Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin. European journal of biochemistry, 1999, Volume: 259, Issue:1-2 Topics: Animals; Biopterins; Cytokines; Endothelium, Vascular; Enzyme Inhibitors; Fibroblasts; Humans; Mice; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Phenylalanine Hydroxylase; Swine; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1999
Blockade of tetrahydrobiopterin synthesis protects neurons after transient forebrain ischemia in rat: a novel role for the cofactor. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Feb-01, Volume: 19, Issue:3 Topics: Animals; Biopterins; Brain; Caspase 3; Caspases; Dopamine; GTP Cyclohydrolase; Hippocampus; Ischemic Attack, Transient; Male; Mice; Microglia; NADPH Dehydrogenase; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Prosencephalon; Rats; Rats, Wistar; RNA, Messenger	1999
Cerebrospinal fluid nitrite plus nitrate correlates with tetrahydrobiopterin concentration. Journal of inherited metabolic disease, 1999, Volume: 22, Issue:3 Topics: Adolescent; Biopterins; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Nitrates; Nitrites	1999
Adrenomedullin augments nitric oxide and tetrahydrobioptein synthesis in cytokine-stimulated vascular smooth muscle cells. Cardiovascular research, 1999, Volume: 44, Issue:1 Topics: Adrenomedullin; Analysis of Variance; Animals; Antioxidants; Biopterins; Cells, Cultured; Enzyme Activation; Gene Expression; GTP Cyclohydrolase; Interleukin-1; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peptides; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Rats, Wistar; RNA, Messenger; Shock, Septic; Vasodilator Agents	1999
Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism? The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:2 Topics: Antimalarials; Biopterins; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Endothelium; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyindoleacetic Acid; Infant; Kenya; Malaria, Cerebral; Microglia; Neopterin; Nitrates; Nitrites; Quinolinic Acid; Tryptophan	2000
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity. Chemical research in toxicology, 2001, Volume: 14, Issue:2 Topics: Antioxidants; Arginine; Biopterins; Guanidines; Hydroxylamines; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Substrate Specificity; Superoxide Dismutase	2001
Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA. The Journal of laboratory and clinical medicine, 2001, Volume: 137, Issue:5 Topics: Amino Acid Transport Systems, Basic; Animals; Antioxidants; Arginine; Biological Transport; Biopterins; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Extracellular Space; Gene Expression Regulation; Lipopolysaccharides; Membrane Proteins; Myocardium; Nitrites; Protein Isoforms; Rats; Rats, Wistar; RNA, Messenger	2001
Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency. Journal of neurochemistry, 2002, Volume: 80, Issue:2 Topics: Adolescent; Adult; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Humans; Infant; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Phenylketonurias; Phosphorus-Oxygen Lyases	2002
Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization. The Journal of biological chemistry, 2002, Dec-06, Volume: 277, Issue:49 Topics: Animals; Biopterins; Blotting, Northern; Blotting, Western; Cells, Cultured; Cyclic GMP; Cytokines; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; GTP Cyclohydrolase; Hepatocytes; Humans; Male; Muscle, Smooth; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Penicillamine; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors; Transfection	2002
Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6 Topics: Animals; Arginine; Biopterins; Gene Expression Regulation; Kidney; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Receptors, LDL; Receptors, Oxidized LDL; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class E; Superoxide Dismutase; Time Factors	2003
Characterization of Drosophila nitric oxide synthase: a biochemical study. Biochemical and biophysical research communications, 2003, Jun-27, Volume: 306, Issue:2 Topics: Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Drosophila; Electrons; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Hydrogen Peroxide; Hydrolysis; NADP; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Open Reading Frames; Protein Structure, Tertiary; Spectrophotometry; Time Factors; Trypsin; Ultraviolet Rays; Urea	2003
Role of ascorbate in the regulation of nitric oxide generation by polymorphonuclear leukocytes. Biochemical and biophysical research communications, 2003, Sep-12, Volume: 309, Issue:1 Topics: Animals; Ascorbic Acid; Biopterins; Blood Platelets; Citrulline; Dehydroascorbic Acid; Flow Cytometry; Haplorhini; Humans; Iodoacetamide; Male; Neutrophils; Nitric Oxide; Nitrites; Oxidation-Reduction; Oxygen; Rats; Rats, Sprague-Dawley	2003
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. Biochemistry, 2003, Nov-18, Volume: 42, Issue:45 Topics: Amino Acids; Arginine; Binding Sites; Biopterins; Catalysis; Dithionite; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Freezing; Heme; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxyhemoglobins; Protein Structure, Tertiary; Pterins; Recombinant Proteins; Time Factors	2003
Inhibition of nuclear factor kappa B activation and inducible nitric oxide synthase transcription by prolonged exposure to high glucose in the human keratinocyte cell line HaCaT. The British journal of dermatology, 2004, Volume: 150, Issue:4 Topics: Antioxidants; Biopterins; Cell Line; Cytokines; DNA; Down-Regulation; Glucose; Humans; Keratinocytes; Lipopolysaccharides; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger; Time Factors; Transcription, Genetic	2004
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. Journal of hypertension, 2005, Volume: 23, Issue:7 Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Time Factors; Tyrosine; Up-Regulation	2005
Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Arginine; Biopterins; Cyclic GMP; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxy Acids; Male; Malondialdehyde; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Potassium Channels; Rats; Rats, Sprague-Dawley	2006
Tetrahydrobiopterin compounds prolong allograft survival independently of their effect on nitric oxide synthase activity. Transplantation, 2006, Feb-27, Volume: 81, Issue:4 Topics: Animals; Biopterins; Graft Survival; Heart Transplantation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase; Nitrites; Transplantation, Homologous	2006
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circulation research, 2006, Jul-07, Volume: 99, Issue:1 Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Drug Synergism; Genetic Therapy; Liver; Metalloporphyrins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitrites; Phenotype; Phosphorylation; Pterins; Reperfusion Injury; Severity of Illness Index; Tyrosine	2006
17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:2 Topics: Animals; Biopterins; Cardiovascular Diseases; Cattle; Cells, Cultured; Diabetes Complications; Down-Regulation; Endothelial Cells; Estradiol; Estrogen Receptor alpha; Female; GTP Cyclohydrolase; Hyperglycemia; Nitric Oxide Synthase Type III; Nitrites; Postmenopause; Protein Kinase C; RNA, Small Interfering	2007
Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats. European journal of pharmacology, 2007, Jan-19, Volume: 555, Issue:1 Topics: Adiponectin; Adipose Tissue; Animals; Aorta, Thoracic; Biopterins; Blood Pressure; Endothelium, Vascular; Fructose; Male; Metabolic Syndrome; Myocardium; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides; Vasodilation	2007
Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states. Journal of inherited metabolic disease, 2007, Volume: 30, Issue:2 Topics: Animals; Biological Availability; Biopterins; Brain; Carrier Proteins; Glutathione; GTP Cyclohydrolase; Kidney; Lipopolysaccharides; Liver; Metabolism, Inborn Errors; Mice; Mutation; Nitrates; Nitric Oxide; Nitrites; Osmolar Concentration; Polycomb Repressive Complex 1	2007
Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus. Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6 Topics: Animals; Aorta; Biopterins; Carotid Arteries; Cholesterol; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; GTP Cyclohydrolase; Lung; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Streptozocin; Superoxides	2008
Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats. Journal of pharmacological sciences, 2008, Volume: 107, Issue:1 Topics: Acetylcholine; Anesthesia, General; Animals; Aorta, Thoracic; Biopterins; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; GTP Cyclohydrolase; Hypoxanthines; Male; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroprusside; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents	2008
Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats. European journal of pharmacology, 2010, Apr-10, Volume: 631, Issue:1-3 Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Biopterins; Dietary Supplements; Endothelium, Vascular; Hemodynamics; Hypertension; In Vitro Techniques; Infusions, Intravenous; Male; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2010
Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:6 Topics: Animals; Biopterins; Blood Pressure; Female; Gene Expression Regulation; Hypertension; Inflammation; Kidney; Kidney Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Ornithine; Oxidative Stress; Rats; Rats, Inbred Lew; Renin; RNA, Messenger; Sodium Chloride, Dietary	2012
Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine. International journal of molecular sciences, 2012, Volume: 13, Issue:6 Topics: Arginine; Biopterins; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Lysine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress	2012
Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat. Molecular medicine (Cambridge, Mass.), 2012, Oct-24, Volume: 18 Topics: Administration, Oral; Animals; Arginine; Ascorbic Acid; Biopterins; Calcium; Drug Synergism; Hindlimb; Ischemia; Male; Models, Biological; Muscles; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Recovery of Function; Regional Blood Flow	2012
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling. Journal of the American Heart Association, 2013, Jan-02, Volume: 2, Issue:1 Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Tyrosine	2013
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats. The aging male : the official journal of the International Society for the Study of the Aging Male, 2014, Volume: 17, Issue:4 Topics: Aging; Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Erectile Dysfunction; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Penile Erection; Penis; Rats, Wistar; Sodium Nitrite	2014