nitrates has been researched along with tyrosine in 864 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 76 (8.80) | 18.7374 |
| 1990's | 221 (25.58) | 18.2507 |
| 2000's | 420 (48.61) | 29.6817 |
| 2010's | 132 (15.28) | 24.3611 |
| 2020's | 15 (1.74) | 2.80 |
| Authors | Studies |
|---|---|
| Evans, DR; Landfear, SM; Lipscomb, WN | 1 |
| Dwek, RA; Gavish, M; Givol, D; Jackson, WR; Neriah, YB; Zakut, R | 1 |
| Imhoff, JM; Keil, B; Svensson, KB | 1 |
| Imhoff, JM; Keil, B | 1 |
| Chanderkar, LP; Gurnani, S; Nadkarni, GB | 1 |
| Beckman, JS; Chen, J; Ischiropoulos, H; Martin, JC; Smith, CD; Tsai, M; Zhu, L | 1 |
| Beckman, JS; Carson, M; Chen, J; Ischiropoulos, H; Smith, CD; van der Woerd, M | 1 |
| Bartsch, H; Brouet, I; Friesen, M; Ohshima, H | 1 |
| Freeman, GB; Gibson, GE; Nielsen, P | 1 |
| Scherrer, P; Stoeckenius, W | 1 |
| Jänig, GR; Kraft, R; Makower, A; Rabe, H; Ruckpaul, K | 1 |
| Cutfield, JF; Cutfield, SM; Dodson, GG; Ronco, N | 1 |
| Dua, RD; Kochhar, S | 1 |
| Doscher, MS; Edwards, BF; Kelly, CE; Martin, PD; Sasaki, DM | 1 |
| Butler, J; Land, EJ; Mönig, H; Prütz, WA | 1 |
| Anderson, GP; Draheim, JE; Gross, EL | 1 |
| Donaldson, PT; Lillie, RD | 1 |
| Bustin, M; Stollar, BD | 1 |
| Hrubant, GR | 1 |
| Damoiseaux, P; Léonis, J; Vincentelli, JB | 1 |
| Corsi, A; Granata, AL; Mühlrad, A | 1 |
| Hiratsuka, T; Uchida, K | 1 |
| Moritz, P; Wade, R | 1 |
| Greer, MA; Milne, KA; Stott, AK | 1 |
| Christen, P; Simpson, RT; Vallee, BL | 1 |
| Benkovic, SJ; DeMaine, MM; Kleinschuster, JJ; Siewers, IJ | 1 |
| Agnihotri, JP; Jain, JP; Solanki, JS | 1 |
| Deyl, Z; Vanćiková, O | 1 |
| Abiko, T | 1 |
| Fan, CC; York, JL | 2 |
| Adman, ET; Jensen, LH; Sieker, LC | 1 |
| Kirschner, MW; Schachman, HK | 1 |
| Bryce, CF; Crichton, RR | 1 |
| Bloch, K; Helmkamp, GM | 1 |
| MacGregor, CH; Schnaitman, CA | 1 |
| Atassi, MZ; Habeeb, AF | 1 |
| Arnon, R; Neurath, H | 1 |
| Chang, CC; Hamaguchi, K; Hayashi, K; Nakai, K; Yang, CC | 1 |
| Chicheportiche, R; Lazdunski, M; Rochat, C; Sampieri, F | 1 |
| Diopoh, J; Olomucki, M | 1 |
| Sokolovsky, M | 1 |
| Brinkley, EC; Dabbous, MK; Seif, M | 1 |
| Skov, K; Williams, GR | 1 |
| Simeon, V; Weber, OA | 1 |
| Shall, S; Waheed, A | 1 |
| Hugli, TE; Stein, WH | 1 |
| Brattin, WJ; Landon, M; Langley, TJ; Melamed, MD; Piszkiewicz, D; Smith, EL | 1 |
| Riordan, JF; Sokolovsky, M; Vallee, BL | 2 |
| Curtis, CR | 1 |
| Pfeifer, S; Wachholz, E | 1 |
| Christen, P | 1 |
| Aviram, I; Schejter, A; Sokolovsky, M | 2 |
| Landon, MF; Oriol, C; Thoai, NV | 1 |
| Guirguis, MA; Vancura, V | 1 |
| Edelhoch, H; Malan, PG | 1 |
| Landon, MF; Oriol, C | 1 |
| Boyd, ND; Smith, DB | 1 |
| Chen, RF | 1 |
| Brovetto-Cruz, J; Li, CH; Ma, L | 1 |
| Atassi, MZ; Habeeb, AF; Perlstein, MT | 1 |
| Riordan, JF; Sokolovsky, M | 1 |
| Fric, I; Meloun, B; Sorm, F | 1 |
| Pettersson, G | 1 |
| Kindl, H | 1 |
| Aktipis, S; Darnall, DW; Garbett, K; Keresztes-Nagy, S; Klotz, IM | 1 |
| Hofmann, T; Skov, K; Williams, GR | 1 |
| Foster, JW; Hodson, PH | 1 |
| Camien, MN | 1 |
| Boroff, DA; DasGupta, BR | 1 |
| Johansen, JT; Ottesen, M; Svendsen, I | 1 |
| Alburn, HE; Grant, NH | 1 |
| Buss, EG; Clagett, CO; Guyer, RB; Ramanathan, L | 1 |
| Garel, JR | 1 |
| Bayliss, ME; Mäkinen, KK; Mäkinen, PL; Prescott, JM; Wilkes, SH | 1 |
| Ischiropoulos, H; Salzman, AL; Szabó, C | 1 |
| al-Mehdi, AB; Fisher, AB; Ischiropoulos, H | 1 |
| Duran, D; Horwitz, J; Ischiropoulos, H | 1 |
| Cross, CE; Eiserich, JP; Halliwell, B; Van der Vliet, A | 1 |
| al-Mehdi, AB; Ischiropoulos, H | 1 |
| Van der Walt, BJ; Van Zyl, JM | 1 |
| Beckman, JS | 3 |
| Barnard, M; Turrens, JF; Watts, BP | 1 |
| Cueto, R; Jin, X; Koppenol, WH; Ngu-Schwemlein, M; Pryor, WA; Squadrito, GL; Uppu, PL; Uppu, RM | 1 |
| Golly, I; Hlavica, P; Kellermann, J; Lehnerer, M | 1 |
| Cross, CE; Eiserich, JP; Halliwell, B; O'Neill, CA; van der Vliet, A; Vossen, V | 1 |
| Vertessy, BG; Zeppezauer, M | 1 |
| Beckman, JS; Galliani, C; Haddad, IY; Hu, P; Matalon, S; Pataki, G | 1 |
| Hammes, WP; Kicherer, M; Straub, BW; Tichaczek, PS | 1 |
| Cross, CE; Halliwell, B; Kaur, H; O'Neill, CA; van der Vliet, A | 1 |
| Albani, JR; Bouquelet, SJ; Helbecque, N; Sicard, PJ; Villette, JR | 1 |
| Guérin, MC; Salman-Tabcheh, S; Torreilles, J | 1 |
| Halliwell, B; Tritschler, H; Whiteman, M | 1 |
| Ghio, AJ; Oury, TD; Piantadosi, CA; Tatro, L | 1 |
| Bigelow, DJ; Ferrington, DA; Hühmer, AF; Schöneich, C; Viner, RI | 1 |
| Heptinstall, J; Richards, PG; Walton, DJ | 1 |
| Chock, PB; Kong, SK; Stadtman, ER; Yim, MB | 1 |
| Duran, D; Gow, AJ; Ischiropoulos, H; Malcolm, S | 1 |
| Hurst, JK; Jiang, Q; Lymar, SV | 1 |
| Buttery, LD; Chester, AH; Evans, TJ; Parums, DV; Polak, JM; Springall, DR; Standfield, EN; Yacoub, MH | 1 |
| Halliwell, B; Kaur, H; Whiteman, M | 1 |
| Berlett, BS; Chock, PB; Friguet, B; Stadtman, ER; Yim, MB | 1 |
| Beckman, JS; Rosen, H; Sampson, JB | 1 |
| Brockman, DE; Eis, AL; Greer, I; Lyall, F; Myatt, L; Rosenfield, RB | 1 |
| Duran, D; Gow, A; Ischiropoulos, H; Thom, SR | 1 |
| Haddad, IY; Matalon, S; Zhu, S | 1 |
| Chou, SM; Komai, K; Wang, HS | 1 |
| Althaus, JS; Fici, GJ; Hall, ED; Von Voigtlander, PF | 1 |
| Kawka, DW; Mumford, RA; Riehl, TE; Scott, S; Singer, II; Stenson, WF; Weidner, JR | 1 |
| Aji, W; Athan, E; Cannon, PJ; Michler, RE; Minanov, OP; Roy, D; Sciacca, RR; Szabolcs, M; Yang, X | 1 |
| Bhattacharya, M; Fiala, ES; Li, H; Sodum, RS | 1 |
| Beckman, JS; Crow, JP; Kerby, JD; MacMillan-Crow, LA; Thompson, JA | 1 |
| Kooy, NW; Lewis, SJ | 2 |
| Halliwell, B; Whiteman, M | 4 |
| Greis, KD; Matalon, S; Zhu, S | 1 |
| Dallner, G; Ernster, L; Forsmark-Andrée, P; Persson, B; Radi, R | 1 |
| Bayer, EA; Morag, E; Wilchek, M | 1 |
| Augusto, O; Capurro, Mde L; de Bianchi, AG; Giorgio, S; Linares, E | 1 |
| Baldwin, J; Francescutti, D; Lee, L; Mutus, B | 1 |
| Mondoro, TH; Shafer, BC; Vostal, JG | 1 |
| Aruoma, OI; England, TG; Halliwell, B; Whiteman, M | 1 |
| Augusto, O; Giorgio, S; Linares, E | 1 |
| Inouye, K; Lee, SB; Tonomura, B | 2 |
| Beckman, JS; Perry, G; Richey Harris, PL; Sayre, LM; Smith, MA | 1 |
| Ames, BN; Blount, BC; Christen, S; Lee, HH; Shigenaga, MK; Shigeno, ET; Yip, H | 1 |
| Fukuyama, N; Hida, M; Ichimori, K; Ishida, H; Nakazawa, H; Takebayashi, Y | 1 |
| Hemmens, B; Leopold, E; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER | 1 |
| Halliwell, B; Pannala, AS; Rice-Evans, CA; Singh, S | 1 |
| Abdalla, DS; Moriel, P | 1 |
| Rabinovitch, A; Suarez-Pinzon, WL; Szabó, C | 1 |
| Barnes, PJ; Giaid, A; Saleh, D | 1 |
| Chandler, RT; Crow, JP; Parks, DA; Skinner, HB; Skinner, KA; Thompson, JA | 1 |
| Beckman, JS; Kelly, DR; Kooy, NW; Lewis, SJ; Royall, JA; Ye, YZ | 1 |
| Curtis, JF; Eling, TE; Gierse, JK; Gunther, MR; Hsi, LC; Marnett, LJ; Mason, RP | 1 |
| Hinton, DR; Hofman, FM; Incardonna, F; van der Veen, RC | 1 |
| Blount, BC; Duncan, MW; Smythe, GA; Yi, D | 1 |
| Minetti, M; Pietraforte, D | 1 |
| Halliwell, B | 1 |
| Martin, C; Ullrich, V; Zou, M | 1 |
| Ischiropoulos, H; Thom, SR; Xu, YA | 1 |
| Fukuyama, N; Koga, Y; Nakazawa, H; Okada, K; Tanaka, K; Umezawa, K | 1 |
| Fu, W; Furukawa, K; Goodman, Y; Luo, H; Mattson, MP | 1 |
| Bachmann, S; Bosse, HM | 1 |
| Beckman, JS; Crow, JP; Sampson, JB; Thompson, JA; Zhuang, Y | 1 |
| Barnes, S; Beckman, JS; Crow, JP; Kirk, M; Strong, M; Ye, YZ | 1 |
| Caputi, AP; Cuzzocrea, S; O'Connor, M; Salzman, AL; Szabó, C; Zingarelli, B | 1 |
| Bruckdorfer, KR; Jacobs, M; Khan, J | 1 |
| Bruckdorfer, KR; Jacobs, M; Khan, J; Naseem, KM | 1 |
| Cuzzocrea, S; Gilad, E; Hake, P; Salzman, AL; Szabó, C; Zingarelli, B | 1 |
| Di Stasi, AM; Mallozzi, C; Minetti, M | 1 |
| Cross, AH; Manning, PT; Misko, TP; Stern, MK | 1 |
| Halliwell, B; Rehman, A; Whiteman, M | 1 |
| Bruce-Keller, AJ; Germeyer, A; Holtsberg, FW; Hutchins, JB; Keller, JN; Kindy, MS; Mattson, MP; St Clair, DK; Steiner, SM; Yen, HC | 1 |
| Ashida, K; Ataka, M; Kamisaki, Y; Kishimoto, Y; Nakamoto, K; Wada, K; Yamada, Y | 1 |
| Barbeito, L; Beckman, JS; Estévez, AG; Henderson, CE; Manuel, SM; Radi, R; Spear, N | 1 |
| Fukuyama, N; Hoshiai, K; Ishida, H; Nakazawa, H; Shinohara, Y; Takizawa, S | 1 |
| Crow, JP; MacMillan-Crow, LA; Thompson, JA | 1 |
| Hansen, P; Heinecke, JW; Holloszy, JO; Leeuwenburgh, C; Shaish, A | 1 |
| Berlett, BS; Levine, RL; Stadtman, ER | 1 |
| Akiba, Y; Fujimori, H; Higuchi, H; Hirokawa, M; Hokari, R; Ishii, H; Kimura, H; Kurose, I; Miura, S; Serizawa, H; Shigematsu, T; Tsuzuki, Y | 1 |
| Halliwell, B; Pannala, AS; Razaq, R; Rice-Evans, CA; Singh, S | 1 |
| Ballard, PL; Ballard, RA; Banks, BA; Ischiropoulos, H; McClelland, M | 1 |
| Di Stasi, AM; Mallozzi, C; Minetti, M; Pietraforte, D | 1 |
| Arai, Y; Cheng, X; Egashira, K; Fukuyama, N; Momii, H; Nakazawa, H; Oyama, Ji; Shimokawa, H; Takeshita, A | 1 |
| Arnaud, S; Ben-Ari, Y; Cachin, N; Charriaut-Marlangue, C; Coeroli, L; Plotkine, D; Plotkine, M; Renolleau, S | 1 |
| Fujimura, T; Murayama, K; Taka, H; Yamakura, F | 1 |
| Hinson, JA; Mayeux, PR; Pike, SL; Pumford, NR | 1 |
| Fukuyama, N; Nakazawa, H; Sakai, M; Sato, M | 1 |
| Adam, JM; Bradley, NJ; Bruckdorfer, KR; Ettelaie, C; James, NJ; Naseem, KM | 1 |
| Choe, N; Hemenway, DR; Kagan, E; Matalon, S; Tanaka, S; Zhu, S | 1 |
| Koppenol, WH | 1 |
| Caputi, AP; Cuzzocrea, S; Longo, G; Villari, D; Zingarelli, B | 1 |
| Beckman, JS; Crow, JP; Sopper, MM; Strong, MJ; Strong, WL | 1 |
| Baier-Bitterlich, G; Fuchs, D; Wede, I; Widner, B; Wirleitner, B | 1 |
| Ischiropoulos, H | 2 |
| Cross, AH; Keeling, RM; Manning, PT; Misko, TP; Schmidt, RE | 1 |
| Beckman, JS; Rosen, H; Sampson, JB; Ye, Y | 1 |
| Ducastel, B; Guittet, O; Henry, Y; Lemaire, G; Lepoivre, M; Rubin, H; Salem, JS | 1 |
| Gon, Y; Hashimoto, N; Kikuchi, H; Nishiyama, A; Nozaki, K; Sono, H; Takagi, Y; Todaka, T; Yodoi, J | 1 |
| Allix, M; Boulu, RR; Charriaut-Marlangue, C; Mésenge, C; Plotkine, M; Verrecchia, C | 1 |
| Quinn, MT; Rohn, TT | 1 |
| Fakhrzadeh, L; Gardner, CR; Heck, DE; Laskin, DL; Laskin, JD; Weinberger, B | 1 |
| Caputi, AP; Cuzzocrea, S; Zingarelli, B | 2 |
| Crowley, JR; Hollenberg, PF; Lin, Hl; Osawa, Y; Roberts, ES; Vuletich, JL | 1 |
| Floyd, RA; Hensley, K; Maidt, ML; Markesbery, WR; Sang, H; Yu, Z | 1 |
| Mayer, B; Pfeiffer, S | 1 |
| Cuzzocrea, S; Marmer, D; Salzman, AL; Scott, GS; Szabó, C; Virág, L | 1 |
| Fukuyama, N; Genka, C; Ishida, H; Nakazawa, H; Su, Z; Todorov, R | 1 |
| Boggs, SE; Hellberg, CB; Lapetina, EG | 1 |
| Halliwell, B; Jenner, P; Marshall, KA; Reist, M | 1 |
| Buurman, WA; Forget, PP; Koster-Kamphuis, L; ter Steege, JC; van Straaten, EA | 1 |
| Bryan, TW; Grisham, MB; Jinkins, PA; Jones, KL; Markewitz, BA; Milligan, SA; Owens, MW; Robbins, RA; Simpson, KL | 1 |
| Ahmed, F; Anthony, GM; Bank, N; Fabry, ME; Kiroycheva, M; Nagel, RL; Singhal, PC | 1 |
| Daiber, A; Mehl, M; Ullrich, V | 1 |
| Cuzzocrea, S; Salzman, AL; Szabó, A; Szabó, C; Virág, L; Zingarelli, B | 1 |
| Halliwell, B; Oldreive, C; Paganga, G; Rice-Evans, C; Zhao, K | 1 |
| Cuzzocrea, S; Salzman, AL; Szabó, C; Zingarelli, B | 1 |
| Haramaki, N; Ikeda, H; Imaizumi, T; Mori, E | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E | 1 |
| Fisher, D; Ischiropoulos, H; Ohnishi, ST; Thom, SR; Xu, YA | 1 |
| Jutila, KL; Nelson, LK; Quinn, MT; Rohn, TT; Sipes, KM; Swain, SD | 1 |
| Jakeman, LB; Scott, GS; Stokes, BT; Szabó, C | 1 |
| Chen, JS; Chen, LW; Chen, SC; Hsu, CM; Wang, JS | 1 |
| Cavallini, D; Fontana, M; Macone, A; Pecci, L | 1 |
| Davidge, ST; Roggensack, AM; Zhang, Y | 1 |
| Barbeito, L; Beckman, JS; Estévez, AG; Manuel, SM; Radi, R; Spear, N | 1 |
| Cannon, C; Gilkeson, G; Goldman, D; Oates, J; Petri, M; Reilly, C | 1 |
| Carthy, CM; Glysing-Jensen, T; Granville, DJ; Koglin, J; McManus, BM; Mudgett, JS; Russell, ME | 1 |
| Minetti, M; Pietraforte, D; Scorza, G | 1 |
| Buurman, WA; Forget, PP; ter Steege, JC | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S | 1 |
| Akizuki, E; Liang, J; Matsuda, T; Matsumura, F; Mori, K; Ogawa, M; Ohshiro, H; Okabe, K; Yamada, S; Yamaguchi, Y | 1 |
| Goss, SP; Hogg, N; Kalyanaraman, B | 1 |
| Baker, CS; Creminon, C; Evans, TJ; Hall, RJ; Maclouf, J; Polak, JM; Pomerance, A; Yacoub, MH | 1 |
| Brito, C; Cayota, AM; Dighiero, G; Gualco, G; Naviliat, M; Radi, R; Tiscornia, AC; Vuillier, F | 1 |
| Balazy, M; Jiang, H | 1 |
| Bruno, J; Holwitt, E; Kalns, J; Kiel, J; Parker, J; Piepmeier, E | 1 |
| Arteel, GE; Bradford, BU; Kadiiska, MB; Mason, RP; Raleigh, JA; Rusyn, I; Thurman, RG | 1 |
| Stanbro, WD | 1 |
| Boven, LA; Gomes, L; Gray, F; Hery, C; Nottet, HS; Portegies, P; Tardieu, M; Verhoef, J | 1 |
| Fujii, T; Nakaki, T | 1 |
| Hammer, E; Hofmann, K | 1 |
| Calingasan, NY; Gibson, GE; Kristal, BS; Lindsay, JG; Park, LC; Sheu, KF; Zhang, H | 1 |
| Jendral, M; Ullrich, V; Zou, M | 1 |
| Briviba, K; Klotz, LO; Schieke, SM; Sies, H | 1 |
| Aeschbach, R; Aruoma, OI; Banni, S; Bianchi, ML; Corongiu, FP; Deiana, M; Dessi, MA; Halliwell, B; Kaur, H; Spencer, JP | 1 |
| Groves, JT | 1 |
| Fung, HL; Maurer, TS; Tabrizi-Fard, MA | 1 |
| Darley-Usmar, VM; Freeman, BA; Jo, H; McAndrew, J; Patel, RP; Sellak, H; White, CR | 1 |
| Halliwell, B; Szabó, C; Whiteman, M | 1 |
| Batinić-Haberle, I; Ferrer-Sueta, G; Fridovich, I; Radi, R; Spasojević, I | 1 |
| Leist, M; Ullrich, V; Zou, MH | 1 |
| MacMillan-Crow, LA; Thompson, JA | 1 |
| Ullrich, V; Yesilkaya, A; Zou, M | 1 |
| Blazar, BR; Haddad, IY; Ingbar, DH; Milla, CE; Panoskaltsis-Mortari, A; Yang, S | 1 |
| Bigelow, DJ; Ferrington, DA; Schöneich, C; Viner, RI; Williams, TD | 1 |
| Celan, I; Chazotte, L; Mower, HF; Ohshima, H; Pignatelli, B | 1 |
| Davis, AR; Nelson, LK; Quinn, MT; Rohn, TT | 1 |
| Kerry, N; Rice-Evans, C | 1 |
| Berlett, BS; Chock, PB; Levine, RL; Stadtman, ER; Tien, M | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E; Micali, A; Zingarelli, B | 1 |
| Caputi, AP; Ciriaco, E; Costantino, G; Cuzzocrea, S; de Sarro, A; de Sarro, G; Laurà, R; Mazzon, E | 1 |
| Amirmansour, C; Bogle, RG; Vallance, P | 1 |
| Maeda, S; Saeki, M | 1 |
| Eliasson, MJ; Ferrante, RJ; Huang, Z; Molliver, ME; Moskowitz, MA; Sasamata, M; Snyder, SH | 1 |
| Kanadia, RN; Kuo, WN; Shanbhag, VP | 1 |
| Di Stasi, AM; Macchia, G; Mallozzi, C; Minetti, M; Petrucci, TC | 1 |
| Bachschmid, M; Zou, MH | 1 |
| Grisham, MB; Koyama, S; Robbins, RA; Sato, E; Simpson, KL | 3 |
| Ali, SF; Crow, JP; Imam, SZ; Islam, F; Newport, GD; Slikker, W | 1 |
| Lehnig, M | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Zingarelli, B | 1 |
| Brown, LA; Fortenberry, JD; Owens, ML; Raghuram, N | 1 |
| Brain, SD; Evans, P; Greenacre, SA; Halliwell, B | 1 |
| Kastenbauer, S; Koedel, U; Pfister, HW | 1 |
| Guittet, O; Lepoivre, M; Roy, B | 1 |
| Beckman, JS; Crow, JP; MacMillan-Crow, LA; Takakura, K | 1 |
| Bauer, JA; Coyle, CM; Jing, L; Mihm, MJ | 1 |
| Caputi, AP; Ciliberto, G; Costantino, G; Cuzzocrea, S; De Sarro, A; De Sarro, G; Mazzon, E | 1 |
| Perry, G; Sayre, LM; Smith, MA | 1 |
| Baker, C; Evans, TW; Gutteridge, JM; Lamb, NJ; Quinlan, GJ | 1 |
| Remington, SJ; Wachter, RM | 1 |
| Doi, U; Kato, Y; Niwa, T; Osawa, T | 2 |
| Higuchi, H; Hokari, R; Ishii, H; Kimura, H; Miura, S; Mizumori, M; Mori, M; Sakaguchi, AA; Suzuki, H; Takeuchi, T; Yoshida, H | 1 |
| Michaelis, ML; Zaidi, A | 1 |
| Farber, HW; Hammerman, SI; Hendra, KP; Klings, ES; Loscalzo, J; Rishikof, DC; Upchurch, GR | 1 |
| Beckman, JS; Darley-Usmar, VM; Go, YM; Jo, H; Maland, MC; Park, H; Patel, RP | 1 |
| Caputi, AP; Ciliberto, G; Costantino, G; Cuzzocrea, S; De Sarro, A; De Sarro, G; Di Rosa, M; Ialenti, A; Mazzon, E; Rombolà, L; Sautebin, L; Thiemermann, C | 1 |
| Kanadia, RN; Kuo, WN; Morgan, R; Shanbhag, VP | 1 |
| Cheng, XS; Egashira, K; Fukuyama, N; Momii, H; Nakazawa, H; Oyama, J; Shimokawa, H; Takeshita, A | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E; Reiter, RJ; Tan, DX | 1 |
| Daikhin, E; Ischiropoulos, H; Raman, CS; Souza, JM; Yudkoff, M | 1 |
| Abu-Soud, HM; Chen, Y; Cohen, PA; Hazen, SL; Hoff, HF; MacPherson, JC; Mitra, SN; Mukhopadhyay, C; Podrez, EA; Schmitt, D; Shen, Z; Wu, W; Zhang, R | 1 |
| Hasegawa, K; Ochiai-Kanai, R; Sawada, T; Takeuchi, Y; Yoshioka, H | 1 |
| Caputi, AP; Cuzzocrea, S; El-Sokkary, GH; Hassanein, AF; Reiter, RJ; Tan, DX | 1 |
| Heinecke, JW; Jackson-Lewis, V; Pennathur, S; Przedborski, S | 1 |
| Aretha, CW; Geddes, TJ; Kuhn, DM | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; De Sarro, A; Mazzon, E | 1 |
| Arteel, GE; Sies, H | 1 |
| Cheung, R; Mutus, B; Tannous, M; Vignini, A | 1 |
| Alber, S; Boyle, P; Dickinson, E; Ford, H; Nadler, E; Tuncer, R; Watkins, S | 1 |
| Kanadia, RN; Kuo, WN; Shanbhag, VP; Toro, R | 1 |
| Halliwell, B; Whiteman, M; Zhao, K | 1 |
| Beckman, JS; Darley-Usmar, V; Digerness, SB; Harris, KD; Kirklin, JW; Urthaler, F; Viera, L | 1 |
| Frost, MT; Halliwell, B; Moore, KP | 1 |
| Boscá, L; Fernández, AP; Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA; Olivenza, R; Rodrigo, J | 1 |
| Czapski, G; Goldstein, S; Lind, J; Merényi, G | 1 |
| Bauer, JA; Holycross, BJ; Wattanapitayakul, SK; Weinstein, DM | 1 |
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| Carr, PW; Reichenbach, SE; Stoll, DR; Tao, Q; Tian, X | 1 |
| Gao, ZH; Huang, XW; Li, D; Lu, NH; Wang, N; Yi, L | 1 |
| de Faria, JB; de Faria, JM; Rosales, MA; Silva, KC | 1 |
| Hou, R; Lau, WB; Liu, S; Tao, L; Wang, H; Yin, T | 1 |
| Gougoura, S; Koukoulis, GN; Liakos, P | 1 |
| Bidmon, HJ; Görg, B; Häussinger, D; Kircheis, G; Palomero-Gallagher, N; Qvartskhava, N; Zilles, K | 1 |
| Connelly, R; Enkhbaatar, P; Esechie, A; Hamahata, A; Herndon, DN; Jonkam, C; Lange, M; Nakano, Y; Schmalstieg, FC; Traber, DL; Traber, LD; von Borzyskowski, S | 1 |
| Atukeren, P; Balcioglu, I; Camlica, H; Gumustas, MK; Purisa, S; Soydinc, HO; Yavuz, B | 1 |
| Liu, B; Liu, KJ; Liu, W; Schnell, A; Yuan, Z | 1 |
| Bertram, J; Brand, P; Eisenbeis, C; Gerards, K; Gube, M; John, AC; Kaminski, H; Kraus, T; Kuhlbusch, T; Wiemann, M; Winkler, R | 1 |
| Cooper, HJ; Jones, AW | 1 |
| Mikkelsen, RB; Yakovlev, VA | 1 |
| Szuba, A; Wojtaszek, P | 1 |
| Gentner, NJ; Weber, LP | 1 |
| Corsetto, P; Montorfano, G; Negri, A; Negroni, M; Nonnis, S; Pagliato, L; Rizzo, AM; Tedeschi, G | 1 |
| Rehman, H; Shi, Y; Wright, GL; Zhong, Z | 1 |
| Kang, S; Poo, H; Ryu, SE; Yoon, SW | 1 |
| Pöschl, U; Yang, H; Zhang, Y | 1 |
| Evers, BM; Saito, H; Starr, ME; Ueda, J; Yamamoto, S | 1 |
| Jou, NT; Li, XY; Ma, SX; Smith, BT | 1 |
| Diaz, A; Guevara, J; Limon, ID; Mendieta, L; Zenteno, E | 1 |
| Bayden, AS; Graves, PR; Kellogg, GE; Mikkelsen, RB; Yakovlev, VA | 1 |
| Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Impellizzeri, D; Mazzon, E | 1 |
| Kim, MS; Moon, JH; Shin, YS | 1 |
| Fernández-Moreira, D; García Ruiz, I; García-Consuegra, I; Gómez-Izquierdo, E; Muñoz-Yagüe, T; Solís-Herruzo, JA; Solís-Muñoz, P | 1 |
| Colom-Moreno, R; León, J; Lozano-Juste, J | 1 |
| Arasimowicz-Jelonek, M; Floryszak-Wieczorek, J | 1 |
| Dunn, JM; Rhoades, E; Sevcsik, E; Trexler, AJ | 1 |
| Al-Dissi, AN; Weber, LP | 1 |
| Barroso, JB; Begara-Morales, JC; Carreras, A; Chaki, M; Corpas, FJ; Fernández-Ocaña, AM; Gómez-Rodríguez, MV; Leterrier, M; López-Jaramillo, J; Luque, F; Sánchez-Calvo, B; Valderrama, R | 1 |
| Juhász, L; Kaszaki, J; Kiss, A; Kovács, M; Nyeso, E; Seprényi, G; Végh, A | 1 |
| Bischoff, R; Dekker, FJ; Haisma, HJ; Maarsingh, H; Poelstra, K; Wisastra, R | 1 |
| Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Impellizzeri, D; Mazzon, E; Melani, A; Paterniti, I; Pedata, F | 1 |
| Choumar, A; Damasse, J; Dauhoo, N; Lettéron, P; Mansouri, A; Moreau, R; Nahon, P; Pessayre, D; Reyl-Desmars, F; Tarhuni, A; Vadrot, N | 1 |
| Gozal, E; Ovechkin, AV; Roberts, AM; Sedoris, KC; Theile, AR | 1 |
| Baumgarten, S; Hecker, M; Hildebrandt, A; Jungmann, A; Müller, OJ; Schöneich, C; Sharov, VS; Wagner, AH | 1 |
| Campos, C; Casado, A; Guzmán, R; López-Fernández, E | 1 |
| Jia, M; Mateoiu, C; Souchelnytskyi, S | 1 |
| Bhabak, KP; Jayavelu, S; Mugesh, G; Satheeshkumar, K | 1 |
| Carvalho, HG; Melo, PM; Ribeiro, I; Seabra, AR; Silva, LS | 1 |
| Francis, MB; Obermeyer, AC; Seim, KL | 1 |
| De la Rosa, MA; Díaz-Moreno, I; Díaz-Quintana, A; García-Heredia, JM; Teixeira, M | 1 |
| Amaning, JK; Bailey, CE; Deford, JH; Dimayuga, VL; Farrar, R; Hammers, DW; Papaconstantinou, J | 1 |
| Binder, LI; Geula, C; Reyes, JF; Vana, L | 1 |
| Hashidoko, Y; Hashimoto, M; Maeda, M; Sakihama, Y; Tahara, S | 1 |
| Bongartz, LG; Braam, B; Cramer, MJ; Doevendans, PA; Gaillard, CA; Goldschmeding, R; Joles, JA; Tilburgs, C; Verhaar, MC | 1 |
| Bastia, E; Galassi, F; Giambene, B; Impagnatiello, F; Lanzi, C; Masini, E; Ongini, E; Pini, A; Somma, T | 1 |
| Aufradet, E; Canet-Soulas, E; Chirico, EN; Dubouchaud, H; Faës, C; Féasson, L; Francina, A; Martin, C; Messonnier, L; Oyono-Enguéllé, S; Pialoux, V; Thiriet, P | 1 |
| De la Rosa, MA; Del Conte, R; Díaz-Moreno, I; Díaz-Quintana, A; Gairí, M; García-Heredia, JM; Nieto, PM | 1 |
| Kaspera, R; Kavanagh, TJ; Kelly, EJ; Mohar, I; Nelson, SD; Takakusa, H | 1 |
| Li, J; Luo, Y; Wang, Y; Zhang, N; Zhong, R | 1 |
| Chavin, KD; Krishnasamy, Y; Lemasters, JJ; Liu, Q; Ramshesh, VK; Rehman, H; Schnellmann, RG; Theruvath, TP; Zhong, Z | 1 |
| Capellini, VK; Celotto, AC; Dalio, MB; Evora, PR; Joviliano, EE; Tirapelli, LF; Viaro, F | 1 |
| Herget, J; Janotka, M; Krüger, A; Ošťádal, P; Vondráková, D | 1 |
| Gao, Z; Li, H; Yuan, C | 1 |
| Hsiao, CC; Lee, CH; Lo, HC; Tsao, LY | 1 |
| Feng, Y; Gao, Z; Huang, Y; Li, H; Li, X; Lu, N | 1 |
| Fukunaga, K; Han, F; Huang, JY; Liao, MH; Lou, YJ; Lu, YM; Shao, XJ; Tao, RR; Tian, Y; Ye, WF | 1 |
| Abrams, M; Bramson, C; Friese, O; Gallavan, R; Hellio Le Graverand, MP; Highkin, M; Lohmander, LS; Misko, TP; Radabaugh, MR; Roman, D | 1 |
| Basic, J; Cvetkovic, T; Ilic, A; Ljubisavljevic, S; Pavlovic, D; Pavlovic, R; Stojanovic, I; Stukalov, M; Vojinovic, S | 1 |
| Basic, J; Cvetkovic, T; Djordjevic, G; Djordjevic, V; Ljubisavljevic, S; Pavlovic, D; Pavlovic, R; Stojanovic, I; Zabar, K | 1 |
| Camerini, S; Crescenzi, M; D'Amore, C; Di Stasi, AM; Macchia, G; Mallozzi, C; Petrucci, TC | 1 |
| Alb, SF; Crăciun, A; Pârvu, AE; Taulescu, MA | 1 |
| Jerin, A; Kass, PH; Nemec, A; Pavlica, Z; Petelin, M; Šentjurc, M; Verstraete, FJ | 1 |
| Kolankaya, D; Korkmaz, A | 1 |
| Abraham, P; Faith, M; Isaac, B; Kanakasabapathy, I; Kolli, VK; Natarajan, K; Ramamoorthy, H | 1 |
| Abad, E; Garcia-Dorado, D; Hernando, V; Inserte, J; Poncelas-Nozal, M; Vilardosa, Ú | 1 |
| Aslan, I; Aslan, M; Tuzcu, H | 1 |
| Chen, L; Li, L; Liu, C; Qiu, P; Wang, A; Wang, H; Zhang, F | 1 |
| De la Rosa, MÁ; Díaz-Moreno, I; Díaz-Quintana, A; García-Heredia, JM; González-Arzola, K | 1 |
| Acikel, S; Arslantas, U; Cimen, T; Dogan, M; Ertem, AG; Yeter, E | 1 |
| Ahmad, P; Ali, A | 1 |
| Girault, HH; Liu, B; Qiao, L | 1 |
| Baldus, S; Chapman, AL; Eiserich, JP; Klinke, A; Kolářová, H; Kremserová, S; Kubala, L; Lau, D; Víteček, J | 1 |
| Lupachyk, S; Obrosov, A; Obrosova, IG; Shevalye, H; Vareniuk, I; Watcho, P; Yorek, MA | 1 |
| Casella, L; Garcia-Serres, R; Latour, JM; Monzani, E; Pizzocaro, S; Thiabaud, G | 1 |
| Cheung, C; Deeb, RS; Gross, SS; Hajjar, DP; Lamon, BD; Nuriel, T; Summers, B | 1 |
| Barroso, JB; Begara-Morales, JC; Chaki, M; Corpas, FJ; Leterrier, M; López-Jaramillo, J; Luque, F; Mata-Pérez, C; Padilla, MN; Palma, JM; Sánchez-Calvo, B; Valderrama, R | 1 |
| Cai, H; Jiang, H; Xu, H; Yan, Z; Yang, L; Yu, G | 1 |
| Gao, Z; Huang, Y; Li, H; Shuai, Y | 1 |
| Du, Y; Lei, S; Liu, H; Qiao, X; Su, W; Xia, Z; Xia, ZY; Xu, J; Yang, QJ; Zhang, L | 1 |
| Ito, S; Katano, T; Lu, J; Setou, M; Shimojo, M; Uchida, H; Yao, I | 1 |
| Álvarez-Paggi, D; Capdevila, DA; Castro, MA; Demicheli, V; Estrín, DA; Murgida, DH; Radi, R; Tórtora, V | 1 |
| Bianchet, MA; Cotter, RJ; Nath, A; Uzasci, L | 1 |
| Batthyány, C; Buschiazzo, A; Demicheli, V; Durán, R; Hugo, M; Larrieux, N; Lima, A; Martí, MA; Martinez, A; Moreno, DM; Peluffo, G; Petruk, AA; Piacenza, L; Piñeyro, D; Radi, R; Robello, C; Trujillo, M | 1 |
| Liu, H; Liu, T; Liu, X; Lu, L; Ma, L; Song, D; Sun, Q; Wang, K; Wang, W; Zhang, H; Zhang, X; Zhen, P; Zuo, X | 1 |
| Adamczyk, R; Bartosz, G; Sadowska-Bartosz, I | 1 |
| Carresi, C; Dagostino, C; Giancotti, LA; Gliozzi, M; Gratteri, S; Malara, N; Mollace, V; Muscoli, C; Muscoli, S; Musolino, V; Palma, E; Romeo, F; Sacco, I; Salvemini, D; Visalli, V; Vitale, C | 1 |
| Cho, KC; Choi, DY; Kang, JW; Kim, KP; Lee, MY; Lee, NY; Park, SH | 1 |
| Chen, B; Ding, S; Hu, J; Liu, L; Wang, X; Yang, J; Ye, Y; Zhuge, Q | 1 |
| Kuwahira, I; Nagai, H; Nara, A; Ogura, S; Shimosawa, T; Shintani-Ishida, K; Shirai, M; Yoshida, K | 1 |
| Bottari, SP | 1 |
| Abián, J; Bartesaghi, S; Becana, M; Calvo-Begueria, L; Pérez-Rontomé, C; Radi, R; Sainz, M; Staudinger, C; Wienkoop, S | 1 |
| Cao, Y; Li, DW; Li, YT; Long, YT | 1 |
| Gönczi, M; Kaszaki, J; Kiss, A; Kohr, MJ; Kovács, M; Miskolczi, G; Murphy, E; Seprényi, G; Végh, Á | 1 |
| Ahmad, A; Bruschetta, G; Crupi, R; Cuzzocrea, S; Di Paola, R; Esposito, E; Impellizzeri, D; Paterniti, I; Prosdocimi, M; Siracusa, R | 1 |
| Guo, H; Li, X; Song, Y; Wang, L; Zhang, G | 1 |
| Calvo-Medina, R; de Diego-Otero, Y; el Bekay, R; Garcia-Guirado, F; Lima-Cabello, E; Perez-Costillas, L; Quintero-Navarro, C; Sanchez-Salido, L | 1 |
| Asensi, M; Cárcel, M; Cháfer-Pericás, C; Cubells, E; Escobar, J; Kuligowski, J; Nuñez, A; Saugstad, OD; Solberg, R; Torres-Cuevas, I; Vento, M | 1 |
| Amirtharaj, GJ; Balasubramanian, KA; Natarajan, SK; Pulimood, A; Ramachandran, A; Venkatraman, A | 1 |
| Batthyany, C; Carballal, S; Demicheli, V; Estrı́n, DA; Ferrer-Sueta, G; Jara, GE; Lima, A; Martí, MA; Moreno, DM; Quijano, C; Radi, R; Ríos, N | 1 |
| Bartesaghi, S; Batthyány, C; Demicheli, V; Lima, A; Mastrogiovanni, M; Radi, R | 1 |
| Chen, HJ; Chen, PF; Lai, PY; Yang, YF | 1 |
| Bordé, Á; Erdei, L; Feigl, G; Kolbert, Z; Molnár, Á | 1 |
| Gu, T; Jia, R; Xu, D; Yang, D | 1 |
| Gao, Z; Li, H; Xu, H; Yang, Z | 1 |
| Gao, Z; Li, H; Ma, L; Yang, Z; Zhang, P | 1 |
| Bizjak, DA; Bloch, W; Gehlert, S; Grau, M; Jacko, D; Zimmer, P | 1 |
| Chen, HC; Lavidis, NA; Sernia, C; Spiers, JG | 1 |
| Cai, YD; Chen, L; Huang, T; Wang, S; Wei, L; Xu, X; Zhang, YH | 1 |
| Gao, Z; Li, H; Ye, H | 1 |
| An, XJ; Luo, YJ; Zhang, CY | 1 |
| Li, P; Li, Y; Wang, S; Wei, J; Yang, Q | 1 |
| Shukla, D; Shukla, S; Zhao, C | 1 |
| Alvarez-Paggi, D; Castro, MA; Murgida, DH; Oviedo-Rouco, S; Radi, R; Spedalieri, C; Tomasina, F; Tortora, V | 1 |
| Cooley, RB; Jang, HS; Mehl, RA; Nguyen, DP; Porter, JJ; Van Fossen, EM; Willi, TS | 1 |
| Abe, T; Awazu, M; Hashiguchi, A; Hida, M | 1 |
| Guo, X; Li, F; Lu, H; Wang, J; Wang, X; Yu, M; Zheng, Z | 1 |
| Frieg, B; Gohlke, H; Görg, B; Häussinger, D; Homeyer, N; Jeitner, T; Qvartskhava, N | 1 |
| Chu, IK; Dong, N; Feng, J; Le Blanc, JCY; Li, M; Quan, Q; Siu, KWM; Spencer, DM | 1 |
| Bianchini, A; Fernandes de Barros Marangoni, L; Ferrier-Pagès, C; Grover, R; Rottier, C | 1 |
| Bae, JW; Im, H; Kim, E; Kim, MO; Kim, SH; Kwon, HJ; Kwon, WS; Ma, L | 1 |
| Afonso, C; Bonino, L; Borthagaray, G; López, E; Medeiros, R; Pitt, A; Rossi, S; Sousa, B; Spickett, C | 1 |
| Gao, Z; Li, H; Li, J; Wei, J; Yin, G | 1 |
| Batthyány, C; Demicheli, V; Lima, A; Radi, R; Sastre, S; Tomasina, F; Tórtora, V; Zeida, A | 1 |
| Hegemann, JD; Liu, L; Long, T; Quan, J; Tao, Y; Tian, H; Uesugi, M; Wang, H; Yao, W; Zhang, W; Zheng, J | 1 |
| Chaput, D; Chavez-Chiang, O; Culver-Cochran, AE; Duro, N; Guergues, J; Kriss, CL; Nadeau, OW; Stevens, SM; Varma, S | 1 |
| Beckmann, B; Blau, LS; Dimina, L; Finkel, A; Jantz, M; Lützow, M; Maassen, N; Mariotti, F; Röhrig, MA; Shushakov, V; Thorns, A; Tsikas, D | 1 |
| Cooley, RB; Estelle, AB; Mehl, RA; Nguyen, KT; Sluchanko, NN; Zhu, P | 1 |
| Jordan, S; Li, B; Liu, A; Traore, E; Usai, R; Wang, Y; Wu, Y; Xie, ZR | 1 |
| Blue, TC; Davis, KM; Dratch, BD; Horwitz, SM; Jones, SK; McWhorter, KL | 1 |
| Aicardo, A; Chavarría, C; Ivagnes, R; Mastrogiovanni, M; Radi, R; Rios, N; Souza, JM | 1 |
36 review(s) available for nitrates and tyrosine
| Article | Year |
|---|---|
Peroxynitrite versus hydroxyl radical: the role of nitric oxide in superoxide-dependent cerebral injury.
Topics: Animals; Brain; Brain Injuries; Humans; Hydroxyl Radical; Nitrates; Nitric Oxide; Superoxide Dismutase; Superoxides; Tyrosine | 1994 |
Peroxynitrite-dependent tyrosine nitration catalyzed by superoxide dismutase, myeloperoxidase, and horseradish peroxidase.
Topics: Kinetics; Nitrates; Peroxidase; Substrate Specificity; Superoxide Dismutase; Tyrosine | 1996 |
Possible roles of nitric oxide and peroxynitrite in murine leishmaniasis.
Topics: Animals; Anions; Hemoglobins; Leishmania major; Leishmaniasis; Mice; Mice, Inbred BALB C; Nitrates; Nitric Oxide; Oxidants; Reactive Oxygen Species; Superoxides; Tyrosine | 1996 |
Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species.
Topics: Animals; Disease Models, Animal; Humans; Nitrates; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 1998 |
Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Death; Cell Survival; Humans; Motor Neurons; Nitrates; Nitric Oxide; Superoxide Dismutase; Tyrosine | 1998 |
Nitration modifying function of proteins, hormones and neurotransmitters.
Topics: Animals; Homeostasis; Hormones; Humans; Neurotransmitter Agents; Nitrates; Nitric Oxide; Oxidants; Oxidative Stress; Proteins; Tetranitromethane; Tyrosine | 1999 |
Peroxynitrite: reactive, invasive and enigmatic.
Topics: Cell Membrane Permeability; Free Radical Scavengers; Mitochondria; Nitrates; Tyrosine | 1999 |
Biological aspects of reactive nitrogen species.
Topics: Animals; Apoptosis; Inflammation; Lipoproteins; Membranes; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Oxidation-Reduction; Signal Transduction; Tyrosine; Vasodilation | 1999 |
Peroxynitrite inactivates prostacyclin synthase by heme-thiolate-catalyzed tyrosine nitration.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epoprostenol; Heme; Humans; Intramolecular Oxidoreductases; Nitrates; Nitric Oxide; Sulfhydryl Compounds; Superoxides; Tyrosine; Vascular Resistance | 1999 |
Nitric oxide: a radical molecule in quest of free radicals in proteins.
Topics: Amino Acids; Animals; Arachidonic Acid; Bacterial Proteins; Binding Sites; Free Radicals; Humans; Iron; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Prostaglandin-Endoperoxide Synthases; Proteins; Tyrosine | 1999 |
Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies.
Topics: Animals; Biomarkers; Disease; Humans; Nitrates; Nitric Oxide; Superoxides; Tyrosine | 1999 |
Nitric oxide, peroxynitrite, and lower respiratory tract inflammation.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cystic Fibrosis; Eosinophils; Humans; Nitrates; Nitric Oxide; Pneumonia; Tyrosine | 2000 |
Unraveling peroxynitrite formation in biological systems.
Topics: Animals; Carbon Dioxide; Cytochrome c Group; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Free Radicals; Humans; Hydroxylation; Immunohistochemistry; Indicators and Reagents; Luminescent Measurements; Nitrates; Oxidants; Oxidative Stress; Phenols; Tyrosine | 2001 |
[Intervention by nitric oxide, NO, and its oxide derivatives particularly in mammals].
Topics: Animals; Humans; Mammals; Nitrates; Nitric Oxide; Protein Processing, Post-Translational; Superoxides; Tyrosine | 2001 |
[Acute coronary syndromes: an update. I. Pathogenesis and drug therapy].
Topics: Acute Disease; Administration, Oral; Adrenergic beta-Antagonists; Angina, Unstable; Anticoagulants; Aspirin; Calcium Channel Blockers; Clinical Trials as Topic; Clopidogrel; Electrocardiography; Fibrinolytic Agents; Humans; Multicenter Studies as Topic; Myocardial Infarction; Nitrates; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Syndrome; Terminology as Topic; Ticlopidine; Tirofiban; Tyrosine | 2001 |
Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts.
Topics: Animals; Antioxidants; Biomarkers; Dopamine; Dopamine Agents; Enzyme Inhibitors; Humans; Indazoles; Methamphetamine; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; PC12 Cells; Rats; Tyrosine | 2001 |
Nitric oxide: a pro-inflammatory mediator in lung disease?
Topics: Animals; Humans; Inflammation Mediators; Lung; Lung Diseases; Nitrates; Nitric Oxide; Peroxynitrous Acid; Respiratory System; Signal Transduction; Tyrosine | 2000 |
Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction.
Topics: Animals; Disease; Humans; Nitrates; Proteins; Signal Transduction; Tyrosine | 2001 |
The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: impact of diet.
Topics: Animals; Diet; Humans; Nitrates; Nitric Oxide; Nitrites; Reactive Nitrogen Species; Tyrosine | 2001 |
Bicarbonate enhances nitration and oxidation reactions in biological systems--role of reactive oxygen and nitrogen species.
Topics: Bicarbonates; Copper; Cyclic N-Oxides; Humans; Hydrogen Peroxide; Hydroxyl Radical; Nitrates; Oxidation-Reduction; Peroxidases; Reactive Nitrogen Species; Reactive Oxygen Species; Spin Trapping; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2001 |
Aging and the role of reactive nitrogen species.
Topics: Aging; Animals; Diet; Humans; Molecular Structure; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteins; Reactive Nitrogen Species; Tyrosine | 2002 |
Roles of nitric oxide and superoxide in inflammation.
Topics: 2-Naphthylamine; Animals; Arginine; Blotting, Western; Capillary Permeability; Chemotaxis, Leukocyte; Citrulline; Fluorescent Dyes; Fluorometry; Inflammation; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rats; Superoxides; Tyrosine | 2003 |
NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?
Topics: Animals; Free Radicals; Humans; Inflammation; Models, Biological; Nitrates; Nitric Oxide; Nitrogen Dioxide; Nitrosation; Peroxidase; Proteins; Signal Transduction; Tyrosine | 2003 |
Astrocyte swelling and protein tyrosine nitration in hepatic encephalopathy.
Topics: Animals; Astrocytes; Brain Edema; Cell Size; Hepatic Encephalopathy; Humans; Nerve Tissue Proteins; Nitrates; Nitric Oxide; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2005 |
Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy.
Topics: Animals; Astrocytes; Brain Chemistry; Hepatic Encephalopathy; Humans; Hyperammonemia; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2005 |
Lipid nitration and formation of lipid-protein adducts: biological insights.
Topics: alpha-Synuclein; Humans; Lipid Metabolism; Lipids; Lipoproteins, LDL; Nitrates; Oxidative Stress; Proteins; Reactive Nitrogen Species; Tyrosine | 2007 |
Methods to detect nitric oxide and its metabolites in biological samples.
Topics: Animals; Fluorometry; Humans; Nitrates; Nitric Oxide; Nitrites; Sulfhydryl Compounds; Tyrosine | 2007 |
New insights into nitric oxide signaling in plants.
Topics: Nitrates; Nitric Oxide; Plant Physiological Phenomena; Plant Proteins; Protein Kinases; Signal Transduction; Tyrosine | 2008 |
Protein tyrosine nitration--functional alteration or just a biomarker?
Topics: Amino Acid Sequence; Biomarkers; Molecular Sequence Data; Nitrates; Proteins; Tyrosine | 2008 |
Protein tyrosine nitration--an update.
Topics: Humans; Immunoglobulins; Nitrates; Nitric Oxide; Nitrosation; Phenols; Proteins; Superoxide Dismutase; Tyrosine | 2009 |
Protein tyrosine nitration in cellular signal transduction pathways.
Topics: Animals; Humans; Nitrates; Nitric Oxide Synthase; Protein Conformation; Protein Processing, Post-Translational; Reactive Nitrogen Species; Signal Transduction; Tyrosine | 2010 |
[Structural modifications of proteins induced by nitric oxide].
Topics: Animals; Cysteine; Cytoplasm; Guanylate Cyclase; Humans; Nitrates; Nitric Oxide; Oxidative Stress; Plants; Proteins; Signal Transduction; Tyrosine | 2010 |
Understanding the fate of peroxynitrite in plant cells--from physiology to pathophysiology.
Topics: Nitrates; Nitric Oxide; Oxidants; Peroxynitrous Acid; Plants; Reactive Oxygen Species; Superoxides; Tyrosine | 2011 |
Recent methodological advances in the analysis of protein tyrosine nitration.
Topics: Mitochondria; Molecular Structure; Nitrates; Nitric Oxide Synthase; Proteins; Tyrosine | 2013 |
Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects.
Topics: Animals; Humans; Mass Spectrometry; Nitrates; Nitrosation; Protein Processing, Post-Translational; Proteins; Proteome; Proteomics; Sensitivity and Specificity; Tyrosine | 2017 |
Protein tyrosine nitration in plants: Present knowledge, computational prediction and future perspectives.
Topics: Arabidopsis; Metabolic Networks and Pathways; Nitrates; Nitric Oxide; Plant Proteins; Plants; Protein Processing, Post-Translational; Proteome; Tyrosine | 2017 |
6 trial(s) available for nitrates and tyrosine
| Article | Year |
|---|---|
Atorvastatin increases ecNOS levels in human platelets of hyperlipidemic subjects.
Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Blood Platelets; Blood Proteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Enzyme Induction; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertriglyceridemia; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Pyrroles; Treatment Outcome; Triglycerides; Tyrosine; Vasodilation | 1999 |
Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation.
Topics: Aged; Animals; Antioxidants; Ascorbic Acid; Atrial Fibrillation; Cardiac Pacing, Artificial; Coronary Artery Bypass; Dogs; Electrophysiology; Female; Heart Atria; Humans; Male; Middle Aged; Multivariate Analysis; Nitrates; Time Factors; Treatment Outcome; Tyrosine | 2001 |
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.
Topics: Adult; Blotting, Western; Catalase; Cerebrospinal Fluid Proteins; Female; Glutathione; Glutathione Disulfide; Humans; Male; Middle Aged; Multiple Sclerosis; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Recurrence; Reference Values; S-Nitrosothiols; Tyrosine | 2002 |
Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization.
Topics: Acetylcholine; Adenosine; Adult; Aged; Cardiac Catheterization; Coronary Circulation; Coronary Disease; Drug Interactions; Endothelin-1; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Oxygen; Tyrosine; Vasodilator Agents | 2005 |
Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis.
Topics: Adult; Anti-Bacterial Agents; Chronic Periodontitis; Dental Scaling; Doxycycline; Female; Gingiva; Humans; Immunohistochemistry; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Root Planing; Tyrosine | 2013 |
Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise.
Topics: Arginine; Citrulline; Creatine; Creatinine; Dietary Supplements; Glutamates; Glutamine; Glycine; Homoarginine; Humans; Lysine; Male; Malondialdehyde; Methyltransferases; Nitrates; Nitrites; Ornithine; Phenylalanine; Sarcosine; Sodium Chloride; Tryptophan; Tyrosine | 2022 |
822 other study(ies) available for nitrates and tyrosine
| Article | Year |
|---|---|
Elimination of cooperativity in aspartate transcarbamylase by nitration of a single tyrosine residue.
Topics: Allosteric Regulation; Amino Acids; Aspartate Carbamoyltransferase; Escherichia coli; Hydrogen-Ion Concentration; Isoelectric Point; Nitrates; Peptide Fragments; Structure-Activity Relationship; Tyrosine | 1978 |
On the role of Tyr 34L in the antibody combining site of the dinitrophenyl binding protein 315.
Topics: Amino Acids; Animals; Binding Sites, Antibody; Carrier Proteins; Dinitrobenzenes; Hydrogen-Ion Concentration; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Nitrates; Nitrobenzenes; Thermolysin; Tyrosine | 1979 |
Enzymic properties of nitrated alpha-chymotrypsin and delta-chymotrypsin.
Topics: Chymotrypsin; Chymotrypsinogen; Hydrogen-Ion Concentration; Kinetics; Nitrates; Trypsin Inhibitors; Tyrosine | 1975 |
Specificity of nitrated alpha- and delta-chymotrypsin.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Kinetics; Nitrates; Structure-Activity Relationship; Substrate Specificity; Tyrosine | 1977 |
The involvement of aromatic amino acids in biological activity of bovine fibrinogen as assessed by gamma-irradiation.
Topics: Amino Acids; Blood Coagulation; Fibrinogen; Free Radicals; Gamma Rays; Nitrates; Potassium Iodide; Radiation Effects; Radiation-Protective Agents; Radiation-Sensitizing Agents; Sodium; Tryptophan; Tyrosine | 1976 |
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase.
Topics: Animals; Binding Sites; Cattle; Erythrocytes; Hydrogen-Ion Concentration; Kinetics; Lasers; Nitrates; Nitric Oxide; Protein Conformation; Spectrum Analysis, Raman; Superoxide Dismutase; Tyrosine | 1992 |
Crystal structure of peroxynitrite-modified bovine Cu,Zn superoxide dismutase.
Topics: Animals; Binding Sites; Cattle; Computer Graphics; Crystallography; Glutamates; In Vitro Techniques; Models, Molecular; Nitrates; Nitrites; Protein Structure, Tertiary; Superoxide Dismutase; Tyrosine; X-Ray Diffraction | 1992 |
Nitrotyrosine as a new marker for endogenous nitrosation and nitration.
Topics: Animals; Blood Proteins; Chromatography, Gas; Humans; Nitrates; Nitroso Compounds; Tyrosine | 1991 |
Monoamine neurotransmitter metabolism and locomotor activity during chemical hypoxia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Hypoxia; Male; Mice; Motor Activity; Nitrates; Serotonin; Tryptophan; Tyrosine | 1986 |
Effects of tyrosine-26 and tyrosine-64 nitration on the photoreactions of bacteriorhodopsin.
Topics: Amino Acid Sequence; Bacteriorhodopsins; Carotenoids; Nitrates; Photochemistry; Protons; Spectrophotometry; Tyrosine | 1985 |
Comparative studies on the accessibility and functional importance of tyrosine residues in cytochrome P-450 isozymes.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; Isoenzymes; Male; Metyrapone; Microsomes, Liver; Molecular Sequence Data; Nitrates; Peptides; Rabbits; Spectrophotometry; Trypsin; Tyrosine | 1988 |
Preparation and activity of nitrated insulin dimer.
Topics: Amino Acids; Animals; Biopolymers; Chromatography, Gel; Chromatography, High Pressure Liquid; Crystallization; Insulin; Macromolecular Substances; Nitrates; Structure-Activity Relationship; Swine; Tetranitromethane; Tyrosine; X-Ray Diffraction | 1986 |
Chemical modification of liquefying alpha-amylase: role of tyrosine residues at its active center.
Topics: Acetylation; alpha-Amylases; Bacillus; Binding Sites; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Mathematics; Nitrates; Tetranitromethane; Tyrosine | 1985 |
A semisynthetic bovine pancreatic ribonuclease containing a unique nitrotyrosine residue.
Topics: Animals; Cattle; Crystallography; Kinetics; Nitrates; Oligopeptides; Pancreas; Protein Conformation; Ribonucleases; Spectrum Analysis; Structure-Activity Relationship; Tyrosine | 1985 |
Reactions of nitrogen dioxide in aqueous model systems: oxidation of tyrosine units in peptides and proteins.
Topics: Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Kinetics; Nitrates; Nitrites; Nitrogen Dioxide; Oxidation-Reduction; Peptides; Proteins; Tyrosine | 1985 |
Plastocyanin conformation: the effect of the oxidation state on the pKa of nitrotyrosine-83.
Topics: Chlorophyll; Chromatography, High Pressure Liquid; Circular Dichroism; Computers; Cytochromes; Cytochromes f; Ethylenediamines; Isoelectric Point; Kinetics; Nitrates; Plant Proteins; Plastocyanin; Protein Conformation; Spectrophotometry, Ultraviolet; Tyrosine; X-Ray Diffraction | 1985 |
Histochemical azo coupling of protein histidine. Brunswik's nitration method.
Topics: Acetates; Animals; Azo Compounds; Histidine; Histocytochemistry; Methods; Nitrates; Proteins; Rats; Staining and Labeling; Tryptophan; Tyrosine | 1972 |
Antigenic determinants in lysine-rich histones.
Topics: Animals; Cattle; Complement Fixation Tests; Complement Inactivator Proteins; Epitopes; Histones; Lysine; Methane; Nitrates; Nitro Compounds; Nitrobenzenes; Peptides; Protein Conformation; Rabbits; RNA; Structure-Activity Relationship; Succinimides; Thymus Gland; Trypsin; Tyrosine | 1973 |
Characterization of the dominant aerobic microorganism in cattle feedlot waste.
Topics: Acetates; Aerobiosis; Animals; Anti-Bacterial Agents; Carbohydrate Metabolism; Carbon; Catalase; Cattle; Cellulose; Chlortetracycline; Chromatography, Paper; Corynebacterium; Culture Media; Feces; Hippurates; Hydrolysis; Lipase; Microbial Sensitivity Tests; Nitrates; Nitrogen; Oxidoreductases; Salts; Staining and Labeling; Starch; Tellurium; Temperature; Tyrosine; Vitamins | 1973 |
[Membrane proteins. I. Chemical modification of tyrosyl residues].
Topics: Binding Sites; Blood Protein Electrophoresis; Blood Proteins; Cell Membrane; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Nitrates; Protein Binding; Protein Conformation; Solubility; Tyrosine | 1974 |
Studies on the properties of chemically modified actin. I. Photooxidation, succinylation, nitration.
Topics: Adenosine Triphosphatases; Alkanes; Anhydrides; Chemical Phenomena; Chemical Precipitation; Chemistry; Light; Muscle Proteins; Nitrates; Oxidation-Reduction; Succinates; Sulfhydryl Compounds; Time Factors; Tryptophan; Tyrosine; Viscosity | 1968 |
Chemical modification of tyrosine residues in heavy meromyosin ATPase.
Topics: Adenosine Triphosphatases; Alkanes; Azo Compounds; Azoles; Chemical Phenomena; Chemistry; Cystamine; Muscle Proteins; Nitrates; Sulfhydryl Compounds; Thioglycolates; Tyrosine | 1971 |
Effect of nitroarginine on phenylalanine under acid hydrolytic conditions.
Topics: Amino Acids; Arginine; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Gas; Fenclonine; Hydrochloric Acid; Hydrogen-Ion Concentration; Hydrolysis; Mass Spectrometry; Methionine; Nitrates; Nitro Compounds; Peptides; Phenylalanine; Tryptophan; Tyrosine | 1971 |
Effects of thiocyanate, perchlorate and other anions on thyroidal iodine metabolism.
Topics: Animals; Borates; Chlorine; Diiodotyrosine; In Vitro Techniques; Iodides; Iodine; Iodine Isotopes; Nitrates; Perchlorates; Rats; Thiocyanates; Thyroid Gland; Tyrosine | 1966 |
Sequential chemical modifications of tyrosyl residues in alkaline phosphatase of Escherichia coli.
Topics: Acetates; Acylation; Alkaline Phosphatase; Alkanes; Anhydrides; Binding Sites; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Gel; Circular Dichroism; Cobalt; Escherichia coli; Kinetics; Nitrates; Nitro Compounds; Oxidation-Reduction; Phosphoric Monoester Hydrolases; Phosphotransferases; Pyrrolidinones; Spectrophotometry; Succinates; Sulfites; Time; Tyrosine; Ultracentrifugation; Zinc | 1971 |
On the mechanism of action of fructose 1,6-diphosphatase. Inhibition by structural analogs of fructose 1,6-diphosphate.
Topics: Acetates; Acylation; Allosteric Regulation; Animals; Binding Sites; Chromatography, Paper; Fluorometry; Fructose-Bisphosphatase; Fructosephosphates; Glycine; Imidazoles; Kinetics; Liver; Nitrates; Osmolar Concentration; Potassium Chloride; Protein Binding; Rabbits; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 1971 |
Effect of temperature and sources of carbon and nitrogen on the conidial germination and appresoria formation in Colletotrichum capsici.
Topics: Alanine; Amino Acids; Ammonium Chloride; Ammonium Sulfate; Carbohydrate Metabolism; Carbon; Glutamine; Methionine; Mitosporic Fungi; Nitrates; Nitrites; Nitrogen; Potassium; Quaternary Ammonium Compounds; Rhamnose; Spores, Fungal; Stereoisomerism; Temperature; Tyrosine | 1974 |
Disappearance of tyrosine residues in collagen with age. Suggestion of a possible reaction mechanism.
Topics: Achilles Tendon; Aging; Amino Acids; Aniline Compounds; Animals; Anisoles; Biphenyl Compounds; Cattle; Collagen; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Nitrates; Nitrobenzenes; Oxidation-Reduction; Pronase; Rats; Solubility; Spectrometry, Fluorescence; Spectrophotometry, Infrared; Tail; Temperature; Tendons; Tyrosine | 1974 |
Syntheses of [Phe(4NO-2)5, Tyr(Me)8]- and [Tyr(Me)5, Phe(4NO-2)8]- bradykinin.
Topics: Bradykinin; Nitrates; Phenylalanine; Tyrosine | 1974 |
The role of tyrosine in the hemerythrin active site.
Topics: Acetylation; Amidines; Animals; Binding Sites; Carrier Proteins; Centrifugation, Density Gradient; Iron; Lysine; Metalloproteins; Nitrates; Protein Binding; Protein Conformation; Protein Denaturation; Spectrophotometry; Spectrophotometry, Ultraviolet; Tyrosine | 1972 |
Structure of a bacterial ferredoxin.
Topics: Amino Acid Sequence; Amino Acids; Ammonium Sulfate; Chemical Phenomena; Chemistry; Chlorides; Computers; Crystallization; Ferredoxins; Iron; Mathematics; Models, Structural; Nitrates; Praseodymium; Samarium; Streptococcus; Sulfur; Tyrosine; Uranium; X-Ray Diffraction | 1973 |
Conformational studies on the nitrated catalytic subunit of aspartate transcarbamylase.
Topics: Amino Acids; Aspartate Carbamoyltransferase; Autoanalysis; Binding Sites; Carbamates; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Ligands; Nitrates; Nitro Compounds; Organophosphorus Compounds; Protein Binding; Protein Conformation; Spectrophotometry; Spectrophotometry, Ultraviolet; Succinates; Sulfhydryl Compounds; Tyrosine; Ultracentrifugation | 1973 |
Subunit interactions in horse spleen apoferritin. Dissociation by extremes of pH.
Topics: Amino Acids; Animals; Apoproteins; Arginine; Autoanalysis; Chromatography, Gel; Cyclohexanes; Ferritins; Guanidines; Horses; Hydrogen-Ion Concentration; Ketones; Lysine; Nitrates; Protein Conformation; Protein Denaturation; Spectrophotometry; Spectrophotometry, Ultraviolet; Spleen; Time Factors; Tyrosine; Ultracentrifugation | 1973 |
Beta-hydroxydecanoyl thioester dehydrase. Studies on molecular structure and active site.
Topics: Alkylation; Amino Acids; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Gel; Cystine; Electrophoresis; Escherichia coli; Esters; Fatty Acids; Histidine; Hydro-Lyases; Hydrogen-Ion Concentration; Methods; Models, Chemical; Molecular Weight; Nitrates; Sulfhydryl Compounds; Tyrosine; Ultracentrifugation | 1969 |
Implication of tyrosine in iron binding in hemerythrin.
Topics: Alkanes; Amino Acid Sequence; Amino Acids; Chromatography, Gel; Indenes; Iron; Ketones; Kinetics; Nitrates; Oxidation-Reduction; Oxygen; Pepsin A; Peptides; Protein Binding; Protein Denaturation; Proteins; Pyrrolidinones; Spectrophotometry; Tryptophan; Tyrosine; Ultracentrifugation; Ultraviolet Rays | 1971 |
Alterations in the cytoplasmic membrane proteins of various chlorate-resistant mutants of Escherichia coli.
Topics: Anaerobiosis; Bacterial Proteins; Cell Membrane; Chlorates; Chlorine; Chromosome Mapping; Culture Media; Cytochromes; Drug Resistance, Microbial; Electrophoresis, Disc; Escherichia coli; Formates; Leucine; Mutation; Nitrates; Oxidoreductases; Succinate Dehydrogenase; Transduction, Genetic; Tritium; Tyrosine | 1971 |
Enzymic and immunochemical properties of lysozyme. I. Derivatives modified at tyrosine. Influence of nature of modification on activity.
Topics: Amino Acids; Animals; Antigens; Binding Sites; Chemical Phenomena; Chemistry; Chickens; Goats; Immune Sera; Immunodiffusion; Muramidase; Nitrates; Ovalbumin; Peptides; Precipitin Tests; Rabbits; Sulfides; Time Factors; Trypsin; Tyrosine | 1969 |
Immunochemical studies on bovine trypsin and trypsinogen derivatives.
Topics: Alanine; Amines; Animals; Antigen-Antibody Reactions; Cattle; Esters; Glycine; Guanidines; Immunochemistry; Immunodiffusion; Methane; Molecular Biology; Nitrates; Precipitin Tests; Rabbits; Trypsin; Trypsinogen; Tyrosine | 1970 |
Studies on the status of tyrosyl residues in cobrotoxin.
Topics: Alkanes; Amino Acid Sequence; Amino Acids; Animals; Chemical Phenomena; Chemistry; Electrophoresis; Female; Hydrogen-Ion Concentration; Immunodiffusion; Ions; Male; Mice; Nitrates; Precipitin Tests; Rabbits; Snakes; Spectrophotometry; Toxins, Biological; Tyrosine; Venoms | 1971 |
Structure-function relationships of neurotoxins isolated from Naja haje venom. Physiochemical properties and identification of the active site.
Topics: Acylation; Amides; Amino Acids; Animals; Binding Sites; Chemical Phenomena; Chemistry; Dansyl Compounds; Hot Temperature; Hydrogen-Ion Concentration; Lysine; Mice; Nitrates; Optical Rotatory Dispersion; Protein Conformation; Protein Denaturation; Snakes; Spectrometry, Fluorescence; Spectrophotometry; Structure-Activity Relationship; Toxins, Biological; Trypsin; Tryptophan; Tyrosine; Ultraviolet Rays; Urea; Venoms | 1972 |
New protein reagents. II. 4-chloro-3,5-dinitrophenacyl bromide.
Topics: Acetophenones; Animals; Bromine; Carboxylic Acids; Cattle; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Thin Layer; Diazomethane; Histidine; Hydrolysis; Indicators and Reagents; Nitrates; Nitro Compounds; Pancreas; Phenylalanine; Ribonucleases; Spectrophotometry; Sulfhydryl Compounds; Tryptophan; Tyrosine; Ultraviolet Rays | 1972 |
Porcine carboxypeptidase B. Nitration of the functional tyrosyl residue with tetranitromethane.
Topics: Amino Acid Sequence; Animals; Autoanalysis; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Paper; Electrophoresis, Paper; Methane; Nitrates; Nitro Compounds; Swine; Tyrosine; Ultracentrifugation | 1972 |
The action of tetranitromethane on acid-soluble tropocollagen.
Topics: Amino Acids; Animals; Cattle; Electrophoresis, Polyacrylamide Gel; Methane; Nitrates; Nitro Compounds; Protein Conformation; Skin; Solubility; Tropocollagen; Tyrosine; Ultracentrifugation; Viscosity | 1972 |
Correlations between optical rotatory dispersion and other spectroscopic properties of ferricytochrome c (horse heart).
Topics: Alkanes; Animals; Chemical Phenomena; Chemistry; Cytochromes; Horses; Hydrogen-Ion Concentration; Myocardium; Nitrates; Optical Rotatory Dispersion; Spectrophotometry; Temperature; Tyrosine | 1971 |
Chelation of some bivalent metal ions by racemic and enantiomeric forms of tyrosine and tryptophan.
Topics: Cadmium; Chelating Agents; Chemical Phenomena; Chemistry; Copper; Drug Stability; Hydrogen-Ion Concentration; Kinetics; Lead; Mathematics; Nickel; Nitrates; Osmolar Concentration; Potentiometry; Stereoisomerism; Tryptophan; Tyrosine; Zinc | 1971 |
Chemical modification of the active site of yeast invertase.
Topics: Acetamides; Alkylation; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Cyanogen Bromide; Cysteine; Dialysis; Enzyme Activation; Histidine; Hydrogen-Ion Concentration; Iodides; Iodine; Iodoacetates; Iodoproteins; Kinetics; Mercaptoethanol; Mercaptoethylamines; Mercury; Methane; Methionine; Models, Chemical; Models, Structural; Nitrates; Nitro Compounds; Organometallic Compounds; Saccharomyces; Spectrophotometry; Sucrase; Tyrosine | 1971 |
Involvement of a tyrosine residue in the activity of bovine pancreatic deoxyribonuclease A.
Topics: Acylation; Amino Acids; Animals; Binding Sites; Calcium; Carbon Isotopes; Catalysis; Cattle; Chromatography, Gel; Chromatography, Thin Layer; Deoxyribonucleases; Histidine; Imidazoles; Nitrates; Nitro Compounds; Optical Rotatory Dispersion; Oxidation-Reduction; Pancreas; Protein Binding; Thermodynamics; Tyrosine | 1971 |
Bovine liver glutamate dehydrogenase: tentative amino acid sequence; identification of a reactive lysine; nitration of a specific tyrosine and loss of allosteric inhibition by guanosine triphosphate.
Topics: Amino Acid Sequence; Animals; Cattle; Chemical Phenomena; Chemistry; Glutamate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanosine Triphosphate; Liver; Lysine; Methods; Molecular Weight; Nitrates; Stereoisomerism; Tyrosine | 1970 |
Tetranitromethane. A reagent for the nitration of tyrosyl residues in proteins.
Topics: Carboxypeptidases; Chemical Phenomena; Chemistry; Enzyme Precursors; Hydrogen-Ion Concentration; Indicators and Reagents; Insulin; Methane; Muramidase; Nitrates; Ovalbumin; Pepsin A; Proteins; Ribonucleases; Serum Albumin, Bovine; Spectrophotometry; Tyrosine | 1966 |
Photoinduced perithecial formation by Nectria haematococca on media containing either L-tyrosine; L-phenylalanine; or D-glucose+NaNO3 as sole carbon and nitrogen sources.
Topics: Ascomycota; Culture Media; Glucose; Hydrogen-Ion Concentration; Light; Nitrates; Phenylalanine; Tyrosine | 1969 |
[Photometric microdetermination of iodo-amino acids and their use for comprehension of the content of tablets].
Topics: Amino Acids; Iodine; Methods; Microchemistry; Nitrates; Photometry; Tablets; Temperature; Thyronines; Thyroxine; Time Factors; Tyrosine | 1969 |
Chemical approaches to intermediates of enzyme catalysis.
Topics: Aldehydes; Alkanes; Aspartate Aminotransferases; Carboxypeptidases; Catalysis; Enzymes; Formates; Fructose-Bisphosphate Aldolase; Hexosephosphates; Indicators and Reagents; Kinetics; Muscles; Nitrates; Picolines; Spectrum Analysis; Tyrosine; Yeasts | 1970 |
Nitrocytochrome c. I. Structure and enzymic properties.
Topics: Alkanes; Amino Acids; Animals; Chromatography, Ion Exchange; Chromatography, Paper; Chymotrypsin; Cyanides; Cytochromes; Electrophoresis; Horses; Mitochondria, Liver; Nitrates; Rats; Tyrosine | 1970 |
[Conformational changes of ATP: arginine phosphotransferase].
Topics: Adenosine Triphosphate; Alkanes; Animals; Arginine; Chemical Phenomena; Chemistry; Crustacea; Glycols; Hydrogen-Ion Concentration; Nitrates; Optical Rotatory Dispersion; Phosphotransferases; Protein Denaturation; Spectrophotometry; Spectrum Analysis; Tyrosine; Ultracentrifugation; Viscosity | 1970 |
The oxidation of pipecolic acid in preincubated soils.
Topics: Alanine; Amino Acids; Aspartic Acid; Carbon; Cellulose; Glucose; Methods; Nitrates; Oxidation-Reduction; Oxygen Consumption; Pectins; Peptones; Pipecolic Acids; Pseudomonas; Soil; Soil Microbiology; Time Factors; Tyrosine | 1970 |
Nitrocytochrome c. II. Spectroscopic properties and chemical reactivity.
Topics: Alkanes; Animals; Ascorbic Acid; Carbon Monoxide; Chemical Phenomena; Chemistry; Cytochromes; Horses; Hydrogen-Ion Concentration; Infrared Rays; Models, Chemical; Models, Structural; Nitrates; Oxidation-Reduction; Protein Binding; Rotation; Spectrophotometry; Tyrosine | 1970 |
Nitration of human serum albumin and bovine and human goiter thyroglobulins with tetranitromethane.
Topics: Alkanes; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Goiter; Humans; Hydrogen-Ion Concentration; Indophenol; Iodine Isotopes; Nitrates; Nitrophenols; Phenols; Serum Albumin; Serum Albumin, Bovine; Solvents; Spectrophotometry; Thyroglobulin; Tyrosine; Ultracentrifugation; Ultraviolet Rays; Urea; Water | 1970 |
[Circular dichroism of various phosphagen phosphotransferases].
Topics: Animals; Arginine; Chemical Phenomena; Chemistry; Circular Dichroism; Creatine Kinase; Crustacea; Nitrates; Phosphotransferases; Rabbits; Sodium Hydroxide; Tyrosine | 1970 |
Tetranitromethane as a nitrating reagent for tyrosine and tyrosine-containing peptides and proteins.
Topics: Alkanes; Autoradiography; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Paper; Chromatography, Thin Layer; Dipeptides; Glycine; Hemoglobins; Indicators and Reagents; Infrared Rays; Nitrates; Peptides; Proteins; Ribonucleases; Spectrophotometry; Tyrosine; Ultraviolet Rays | 1971 |
Fluorescence quenching due to mercuric ion interaction with aromatic amino acids and proteins.
Topics: Benzoates; Chemical Phenomena; Chemistry; Chymotrypsin; Energy Transfer; Enzyme Precursors; Fluorescence; Indoles; Lactoglobulins; Mercury; Nitrates; Ovalbumin; Phenylalanine; Serum Albumin; Spectrophotometry; Tryptophan; Tyrosine; Ultraviolet Rays | 1971 |
Human pituitary growth hormone. XXVII. Reaction with tetranitromethane.
Topics: Alkanes; Amino Acids; Animals; Bone and Bones; Chromatography, Gel; Columbidae; Crop, Avian; Growth Hormone; Guanidines; Humans; Nitrates; Rats; Spectrophotometry; Tibia; Trypsin; Tyrosine | 1971 |
Conformational studies on modified proteins and peptides. IV. Conformation of lysozyme derivatives modified at tyrosine or at tryptophan residues.
Topics: Amines; Antigens; Binding Sites; Chemical Phenomena; Chemistry; Circular Dichroism; Detergents; Hydrogen-Ion Concentration; Muramidase; Nitrates; Nitrobenzenes; Optical Rotatory Dispersion; Oxidation-Reduction; Protein Binding; Sulfenic Acids; Sulfides; Sulfuric Acids; Tryptophan; Tyrosine | 1971 |
Reduction of nitrotyrosyl residues in proteins.
Topics: Aniline Compounds; Autoanalysis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Electrophoresis; Nitrates; Oxidation-Reduction; Phenols; Proteins; Sulfonic Acids; Tyrosine | 1971 |
Nitration of tyrosine residues in the pancreatic trypsin inhibitor with tetranitromethane.
Topics: Chemical Phenomena; Chemistry; Chemistry, Physical; Chromatography, Ion Exchange; Chromatography, Paper; Dextrans; Electrophoresis; Methane; Methylcellulose; Nitrates; Optical Rotatory Dispersion; Oxidation-Reduction; Pancreas; Paper; Spectrophotometry; Trypsin Inhibitors; Tyrosine; Ultraviolet Rays | 1968 |
Structure and function of a cellulase from Penicillium notatum as studies by chemical modification and solvent accessibility.
Topics: Azoles; Chemical Phenomena; Chemistry; Diazonium Compounds; Fluorescence; Glycoside Hydrolases; Histidine; Hot Temperature; Hydrogen-Ion Concentration; Nitrates; Oxidation-Reduction; Penicillium; Riboflavin; Spectrophotometry; Succinates; Tryptophan; Tyrosine | 1968 |
Biosynthesis and metabolism of hydroxyphenylacetic acids in higher plants.
Topics: Bromine; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Models, Biological; Nitrates; Peroxidases; Phenylacetates; Plants; Shikimic Acid; Tritium; Tyrosine | 1969 |
Optical rotatory properties of hemerythrin in the ultraviolet range.
Topics: Azides; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Iron; Nitrates; Optical Rotatory Dispersion; Proteins; Spectrum Analysis; Tyrosine; Ultraviolet Rays | 1969 |
The nitration of cytochrome c.
Topics: Alkanes; Animals; Chemical Phenomena; Chemistry; Cytochromes; Horses; Hydrogen-Ion Concentration; Myocardium; Nitrates; Spectrophotometry; Tyrosine | 1969 |
Dipicolinic acid synthesis in Penicillium citreo-viride.
Topics: Ammonium Chloride; Carbon Isotopes; Chromatography; Colorimetry; Histidine; In Vitro Techniques; Leucine; Nitrates; Pyridines; Tyrosine; Urea; Valine | 1966 |
Titrimetric microdetermination of sulfur in biological materials.
Topics: Chlorides; Feces; Hexosephosphates; Methionine; Microchemistry; Nitrates; Phosphates; Phosphines; Quaternary Ammonium Compounds; Serine; Sulfates; Sulfur; Tyrosine | 1966 |
Interference in nitrosonaphthol method of tyrosine assay due to chloride.
Topics: Ammonium Chloride; Calcium Chloride; Chemical Phenomena; Chemistry; Chlorides; Hydrochloric Acid; Naphthalenes; Nitrates; Nitroso Compounds; Serotonin; Sodium Chloride; Tyrosine | 1966 |
Environmentally sensitive tyrosyl residues. Nitration with tetranitromethane.
Topics: Carboxypeptidases; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Indicators and Reagents; Methane; Nitrates; Spectrophotometry; Tyrosine | 1967 |
Chemical derivatives of subtilisin Carlsberg with increased proteolytic activity.
Topics: Carbamates; Caseins; Chemical Phenomena; Chemistry; Endopeptidases; Gelatin; Iodine; Kinetics; Nitrates; Protamines; Succinates; Tyrosine | 1967 |
Reactions in frozen systems. VI. Ice as a possible model for biological structured-water systems.
Topics: Acetylcholine; Asparagine; Catalysis; Chemical Phenomena; Chemistry; Copper; Cytosine; Dioxins; Glutamates; Glutamine; Glycine; Hydroxylamines; Ice; Imidazoles; Kinetics; Models, Theoretical; Nitrates; Phenylalanine; Piperazines; Potassium Chloride; Pyrazoles; Serine; Tyrosine | 1967 |
Chemical modifications of riboflavin-binding protein: effects on function and antigenicity.
Topics: Acetamides; Antigens; Binding Sites; Carrier Proteins; Dinitrobenzenes; Epitopes; Glycoproteins; Immunodiffusion; Maleates; Nitrates; Protein Binding; Riboflavin; Succinates; Tryptophan; Tyrosine | 1980 |
Evidence for involvement of proline cis-trans isomerization in the slow unfolding reaction of RNase A.
Topics: Guanidines; Hydrogen-Ion Concentration; Ions; Isomerism; Kinetics; Nitrates; Peptide Fragments; Proline; Protein Denaturation; Ribonucleases; Tyrosine | 1980 |
Chemical modification of Aeromonas aminopeptidase. Evidence for the involvement of tyrosyl and carboxyl groups in the activity of the enzyme.
Topics: Aeromonas; Aminopeptidases; Azo Compounds; Binding Sites; Carboxylic Acids; Chemical Phenomena; Chemistry; Enzyme Activation; Kinetics; Nitrates; Oxidation-Reduction; Photochemistry; Tyrosine | 1982 |
Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Calcium; Endotoxins; Fluorescent Antibody Technique; Lipopolysaccharides; Male; Nitrates; Nitric Oxide Synthase; Rats; Rats, Wistar; Tyrosine | 1995 |
Reactive species in ischemic rat lung injury: contribution of peroxynitrite.
Topics: Animals; Arginine; Immunohistochemistry; Ischemia; Lung; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Perfusion; Pressure; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Staining and Labeling; Tyrosine | 1995 |
Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells.
Topics: Animals; Dihydroxyphenylalanine; Molsidomine; Nitrates; Oxidation-Reduction; PC12 Cells; Rats; Tyrosine | 1995 |
Modification of aromatic amino acids by reactive nitrogen species.
Topics: Free Radicals; Hydrogen-Ion Concentration; Hydroxyl Radical; Hydroxylation; Kinetics; Mannitol; Nitrates; Nitric Oxide; Nitrogen Dioxide; Nitrogen Oxides; Oxidants; Phenylalanine; Tyrosine | 1995 |
Peroxynitrite-mediated oxidative protein modifications.
Topics: Animals; Cysteine; Electrophoresis, Polyacrylamide Gel; Fluorescence; Hydrogen-Ion Concentration; Male; Nitrates; Oxidation-Reduction; Oxidative Stress; Phenylhydrazines; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Tryptophan; Tyrosine | 1995 |
Apparent hydroxyl radical generation without transition metal catalysis and tyrosine nitration during oxidation of the anti-tubercular drug, isonicotinic acid hydrazide.
Topics: Catalase; Hydroxyl Radical; Isoniazid; Kinetics; Metals; Nitrates; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Thiobarbituric Acid Reactive Substances; Tyrosine | 1994 |
Peroxynitrite-dependent chemiluminescence of amino acids, proteins, and intact cells.
Topics: Amino Acids; Animals; Bicarbonates; Cells, Cultured; Fatty Acids; Hemin; Histones; Hydrogen-Ion Concentration; Luminescent Measurements; Nitrates; Nucleic Acids; Nucleotides; Oxidation-Reduction; Peroxides; Proteins; Serum Albumin, Bovine; Spectrophotometry; tert-Butylhydroperoxide; Trypanosomatina; Tryptophan; Tyrosine | 1995 |
A practical method for preparing peroxynitrite solutions of low ionic strength and free of hydrogen peroxide.
Topics: Azides; Buffers; Drug Contamination; Drug Stability; Free Radicals; Freezing; Hydrogen Peroxide; Hydrogen-Ion Concentration; Nitrates; Osmolar Concentration; Ozone; Sodium Azide; Solutions; Spectrophotometry; Tyrosine | 1995 |
Chemical modification of Tyr34 and Tyr129 in rabbit liver microsomal cytochrome b5 affects interaction with cytochrome P-450 2B4.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes b5; Electron Transport; Male; Microsomes, Liver; Nitrates; Rabbits; Spectrophotometry, Ultraviolet; Tyrosine | 1994 |
Molecular mechanisms of damage by excess nitrogen oxides: nitration of tyrosine by gas-phase cigarette smoke.
Topics: Antioxidants; Gases; Nicotiana; Nitrates; Nitrogen Oxides; Oxygen; Phosphorylation; Plants, Toxic; Smoke; Tyrosine | 1994 |
Identification of tyrosine as an active site residue involved in the catalytic mechanism of Escherichia coli dUTPase.
Topics: Acetylation; Binding Sites; Catalysis; Escherichia coli; Nitrates; Pyrophosphatases; Tyrosine; X-Ray Diffraction | 1994 |
Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.
Topics: Adolescent; Animals; Child; Child, Preschool; Female; Fluorescent Antibody Technique; Humans; Infant; Infant, Newborn; Lung; Male; Microtomy; Nitrates; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome, Newborn; Tyrosine | 1994 |
Formation of tyramine by Lactobacillus curvatus LTH 972.
Topics: Amino Acid Sequence; Fermentation; Food Microbiology; Glucose; Hydrogen-Ion Concentration; Lactobacillus; Meat Products; Molecular Sequence Data; Nitrates; Nitrites; Peptides; Temperature; Tyramine; Tyrosine | 1994 |
Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evidence for hydroxyl radical production from peroxynitrite.
Topics: Hydroxyl Radical; Hydroxylation; Nitrates; Phenylalanine; Serum Albumin, Bovine; Thermodynamics; Tyrosine; Uric Acid | 1994 |
Cyclomaltodextrin glucanotransferase from Bacillus circulans E 192: nitration with tetranitromethane.
Topics: Acarbose; Bacillus; Circular Dichroism; Glucosyltransferases; Kinetics; Nitrates; Spectrometry, Fluorescence; Tetranitromethane; Trisaccharides; Tyrosine | 1993 |
Nitration of tyrosyl-residues from extra- and intracellular proteins in human whole blood.
Topics: Blood Proteins; Calcimycin; Humans; Ionophores; Kinetics; Neutrophils; Nitrates; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1995 |
Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by oxidized and reduced lipoic acid.
Topics: alpha 1-Antitrypsin; Antioxidants; Free Radical Scavengers; Humans; In Vitro Techniques; Nitrates; Nitric Oxide; Oxidation-Reduction; Reactive Oxygen Species; Thioctic Acid; Tyrosine | 1996 |
Nitration of tyrosine by hydrogen peroxide and nitrite.
Topics: Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxylation; Inflammation; Iron; Nitrates; Oxidative Stress; Salicylates; Salicylic Acid; Sodium Nitrite; Tyrosine | 1995 |
Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process?
Topics: Aging; Animals; Calcium; Calcium-Transporting ATPases; Male; Muscle, Skeletal; Nitrates; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Tyrosine | 1996 |
The effects of tyrosine nitration on the structure and function of hen egg-white lysozyme.
Topics: Animals; Cell Wall; Chickens; Electrochemistry; Female; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Micrococcus luteus; Models, Molecular; Molecular Structure; Muramidase; Nitrates; Ovum; Point Mutation; Protein Conformation; Substrate Specificity; Tyrosine | 1996 |
Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.
Topics: Amino Acid Sequence; CDC2 Protein Kinase; Cell Cycle; Edetic Acid; Ferric Compounds; In Vitro Techniques; Iron Chelating Agents; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Nitrates; Peptide Fragments; Phosphorylation; Signal Transduction; src-Family Kinases; Tyrosine | 1996 |
Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation.
Topics: Animals; Cattle; Endothelium, Vascular; Erythrocytes; Gastrins; Humans; Nitrates; Peptides; Phosphorylation; Plasma; Protein-Tyrosine Kinases; Proteins; Serum Albumin, Bovine; Tyrosine | 1996 |
Mechanism of carbon dioxide-catalyzed oxidation of tyrosine by peroxynitrite.
Topics: Carbon Dioxide; Chromatography, High Pressure Liquid; Kinetics; Nitrates; Oxidation-Reduction; Time Factors; Tyrosine | 1996 |
Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Biomarkers; Blotting, Western; Female; Foam Cells; Humans; In Situ Hybridization; Macrophages; Male; Middle Aged; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide Synthase; RNA, Messenger; Tyrosine | 1996 |
Protection against peroxynitrite dependent tyrosine nitration and alpha 1-antiproteinase inactivation by some anti-inflammatory drugs and by the antibiotic tetracycline.
Topics: Acetaminophen; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Flufenamic Acid; Free Radical Scavengers; Humans; Mesalamine; Nitrates; Pancreatic Elastase; Penicillamine; Phenylbutazone; Tetracycline; Tyrosine | 1996 |
Peroxynitrite-mediated nitration of tyrosine residues in Escherichia coli glutamine synthetase mimics adenylylation: relevance to signal transduction.
Topics: Cations, Divalent; Escherichia coli; Glutamate-Ammonia Ligase; Manganese; Methionine; Nitrates; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1996 |
Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action.
Topics: Adult; Drug Residues; Female; Fetal Growth Retardation; Humans; Immunohistochemistry; Nitrates; Placenta; Pre-Eclampsia; Pregnancy; Tyrosine | 1996 |
Carbon dioxide enhancement of peroxynitrite-mediated protein tyrosine nitration.
Topics: Adult; Animals; Antioxidants; Bicarbonates; Blood Proteins; Carbon Dioxide; Catalysis; Cattle; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Nitrates; Proteins; Serum Albumin, Bovine; Tyrosine | 1996 |
Nitration of surfactant protein A (SP-A) tyrosine residues results in decreased mannose binding ability.
Topics: Animals; Binding Sites; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lipid Peroxidation; Liposomes; Mannose; Molsidomine; Nitrates; Nitric Oxide; Oxidative Stress; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Superoxides; Tetranitromethane; Tyrosine | 1996 |
Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study.
Topics: Amyotrophic Lateral Sclerosis; Citrulline; Cyclic GMP; Cytoplasm; Humans; Immunohistochemistry; Motor Neurons; Neurofilament Proteins; Nitrates; Nitric Oxide; Nitrogen; Oxidation-Reduction; Superoxide Dismutase; Tyrosine | 1996 |
Protective effects of tirilazad mesylate in a cellular model of peroxynitrite toxicity.
Topics: Aminoisobutyric Acids; Animals; Biomarkers; Cells, Cultured; Cerebellum; Emulsions; Free Radical Scavengers; Lipid Peroxides; Nitrates; Pregnatrienes; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease.
Topics: Aged; Aged, 80 and over; Animals; Colon; Diverticulitis, Colonic; Female; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Middle Aged; Nitrates; Nitric Oxide Synthase; Rabbits; RNA, Messenger; Tyrosine | 1996 |
Apoptosis of cardiac myocytes during cardiac allograft rejection. Relation to induction of nitric oxide synthase.
Topics: Animals; Apoptosis; Enzyme Induction; Graft Rejection; Heart Transplantation; Macrophages; Male; Myocardium; Nitrates; Nitric Oxide Synthase; Rats; Rats, Inbred Lew; Rats, Inbred WF; RNA, Messenger; Tyrosine | 1996 |
(-)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Catechin; Cattle; Deoxyguanosine; DNA; Free Radical Scavengers; Nitrates; Oxidation-Reduction; Tea; Tyrosine | 1996 |
Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.
Topics: Amino Acid Sequence; Analysis of Variance; Blotting, Western; Graft Rejection; Humans; Immunohistochemistry; Kidney; Kidney Transplantation; Models, Biological; Nitrates; Peptide Fragments; Superoxide Dismutase; Transplantation, Homologous; Tyrosine | 1996 |
Nitrotyrosine attenuates the hemodynamic effects of adrenoceptor agonists in vivo: relevance to the pathophysiology of peroxynitrite.
Topics: Adrenergic Agonists; Animals; Arginine Vasopressin; Hemodynamics; Male; Nitrates; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants.
Topics: alpha 1-Antitrypsin; Antioxidants; Arthritis, Rheumatoid; Ascorbic Acid; Humans; Lipid Peroxidation; Nitrates; Oxidation-Reduction; Oxidative Stress; Pancreatic Elastase; Synovial Fluid; Tyrosine | 1996 |
Identification of nitration sites on surfactant protein A by tandem electrospray mass spectrometry.
Topics: Amino Acid Sequence; Humans; Mass Spectrometry; Molecular Sequence Data; Nitrates; Peptide Fragments; Peptide Mapping; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Tyrosine | 1996 |
Oxidative modification of nicotinamide nucleotide transhydrogenase in submitochondrial particles: effect of endogenous ubiquinol.
Topics: Adenosine Diphosphate; Animals; Ascorbic Acid; Blotting, Western; Cattle; Ferric Compounds; Kinetics; Lipid Peroxides; NAD; NADP; NADP Transhydrogenases; Nitrates; Oxidation-Reduction; Peptide Mapping; Stress, Physiological; Submitochondrial Particles; Tyrosine; Ubiquinone | 1996 |
Immobilized nitro-avidin and nitro-streptavidin as reusable affinity matrices for application in avidin-biotin technology.
Topics: Animals; Avidin; Bacterial Proteins; beta-Glucosidase; Binding Sites; Biotechnology; Biotin; Chromatography, Affinity; Humans; Immunoglobulin G; Ligands; Nitrates; Rabbits; Streptavidin; Transferrin; Tyrosine | 1996 |
The peroxynitrite product 3-nitro-L-tyrosine attenuates the hemodynamic responses to angiotensin II in vivo.
Topics: Anesthesia; Angiotensin II; Animals; Hemodynamics; Male; Nitrates; Pentobarbital; Rats; Rats, Sprague-Dawley; Tyrosine; Vasoconstrictor Agents | 1996 |
Formation of nitrosyl hemoglobin and nitrotyrosine during murine leishmaniasis.
Topics: Animals; Disease Models, Animal; Female; Hemoglobins; Leishmania mexicana; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Nitrates; Nitric Oxide; Photobiology; Tyrosine | 1996 |
Peroxynitrite modification of glutathione reductase: modeling studies and kinetic evidence suggest the modification of tyrosines at the glutathione disulfide binding site.
Topics: Animals; Binding Sites; Blotting, Western; Cattle; Glutathione; Glutathione Reductase; Hydrogen Bonding; Intestinal Mucosa; Kinetics; Models, Molecular; NADP; Nitrates; Protein Binding; Protein Conformation; Solvents; Spectrometry, Fluorescence; Tyrosine | 1996 |
Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics.
Topics: alpha 1-Antitrypsin; Anti-Bacterial Agents; Free Radical Scavengers; Nitrates; Tyrosine | 1997 |
Peroxynitrite-induced tyrosine nitration and phosphorylation in human platelets.
Topics: Blood Platelets; Blood Proteins; Humans; Nitrates; P-Selectin; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Serotonin; Thrombin; Tyrosine | 1997 |
Antioxidant action of ergothioneine: assessment of its ability to scavenge peroxynitrite.
Topics: alpha 1-Antitrypsin; Antioxidants; Ergothioneine; Free Radical Scavengers; Nitrates; Tyrosine | 1997 |
The states of tyrosyl residues in thermolysin as examined by nitration and pH-dependent ionization.
Topics: Absorption; Hydrogen-Ion Concentration; Ions; Kinetics; Nitrates; Phenols; Spectrophotometry, Atomic; Spectrophotometry, Ultraviolet; Tetranitromethane; Thermolysin; Time Factors; Tyrosine | 1997 |
Widespread peroxynitrite-mediated damage in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Entorhinal Cortex; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurons; Nitrates; Oxidative Stress; Tyrosine | 1997 |
Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection.
Topics: Animals; Blood Proteins; Cell Line; Chromatography, High Pressure Liquid; Electrochemistry; Gas Chromatography-Mass Spectrometry; Inflammation; Macrophage Activation; Male; Nitrates; Nitric Oxide; Rats; Rats, Inbred F344; Tyrosine; Zymosan | 1997 |
Thiourea and dimethylthiourea inhibit peroxynitrite-dependent damage: nonspecificity as hydroxyl radical scavengers.
Topics: alpha 1-Antitrypsin; Enzyme Inhibitors; Free Radical Scavengers; Hydroxyl Radical; Nitrates; Thiourea; Tyrosine | 1997 |
Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Free Radicals; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitrates; Nitric Oxide; Shock, Septic; Superoxides; Tyrosine | 1997 |
Interference of carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions.
Topics: Animals; Benzoates; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Serum Albumin, Bovine; Swine; Tyrosine | 1997 |
Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols.
Topics: Catechin; Free Radical Scavengers; Humans; Lipoproteins, LDL; Nitrates; Reference Standards; Tyrosine | 1997 |
Nitrotyrosine bound to beta-VLDL-apoproteins: a biomarker of peroxynitrite formation in experimental atherosclerosis.
Topics: Animals; Arteriosclerosis; Biomarkers; Blood Proteins; Cholesterol; Hypercholesterolemia; Lipoproteins, VLDL; Male; Nitrates; Rabbits; Triglycerides; Tyrosine | 1997 |
Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells.
Topics: Animals; Cell Count; Diabetes Mellitus, Type 1; Female; Islets of Langerhans; Leukocytes; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Nitrates; Tyrosine | 1997 |
Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis.
Topics: Endothelium, Vascular; Epithelium; Female; Humans; Immunohistochemistry; In Situ Hybridization; Lung; Macrophages, Alveolar; Male; Middle Aged; Nitrates; Oxidants; Pulmonary Fibrosis; Tyrosine | 1997 |
Free and protein-associated nitrotyrosine formation following rat liver preservation and transplantation.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Free Radicals; Humans; Liver; Liver Transplantation; Nitrates; Organ Preservation; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 1997 |
Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite.
Topics: Adolescent; Autopsy; Child; Child, Preschool; Densitometry; Female; Humans; Infant; Infant, Newborn; Male; Myocarditis; Nitrates; Nitrosation; Retrospective Studies; Sepsis; Tyrosine | 1997 |
Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation.
Topics: Arachidonic Acid; Blotting, Western; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrazines; Mutagens; Nitrates; Nitric Oxide; Nitrogen Oxides; Prostaglandin-Endoperoxide Synthases; Superoxide Dismutase; Tyrosine | 1997 |
Extensive peroxynitrite activity during progressive stages of central nervous system inflammation.
Topics: Animals; Antibody Specificity; Brain; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Free Radicals; Immunohistochemistry; Lipid Peroxidation; Mice; Mice, Inbred Strains; Neuritis, Autoimmune, Experimental; Neurons; Nitrates; Nitric Oxide; Spinal Cord; Staining and Labeling; Tyrosine | 1997 |
Peroxynitrite-mediated nitration of peptides: characterization of the products by electrospray and combined gas chromatography-mass spectrometry.
Topics: Chromatography, Liquid; Enkephalin, Leucine; Gas Chromatography-Mass Spectrometry; Hemoglobins; HIV Envelope Protein gp120; Mass Spectrometry; Nitrates; Peptide Fragments; Trimethylsilyl Compounds; Tyrosine | 1997 |
Direct ESR detection or peroxynitrite-induced tyrosine-centred protein radicals in human blood plasma.
Topics: Amino Acid Sequence; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Molecular Sequence Data; Nitrates; Sulfhydryl Compounds; Tyrosine; Uric Acid | 1997 |
What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
Topics: Biomarkers; Free Radicals; Humans; Molecular Structure; Nitrates; Nitric Oxide; Nitrogen Dioxide; Nitrous Acid; Peroxidase; Superoxides; Tyrosine | 1997 |
Tyrosine nitration as a mechanism of selective inactivation of prostacyclin synthase by peroxynitrite.
Topics: Animals; Cattle; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Humans; Intramolecular Oxidoreductases; Nitrates; Nitric Oxide; Superoxides; Tyrosine | 1997 |
Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure.
Topics: Animals; Arginine; Carbon Monoxide; Cattle; Cell Survival; Cells, Cultured; Chromium; Endothelium, Vascular; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidants; Oxidation-Reduction; Oxygen Consumption; Sulfhydryl Compounds; Tetrazolium Salts; Thiazoles; Tyrosine | 1997 |
Nitric oxide mediates murine cytomegalovirus-associated pneumonitis in lungs that are free of the virus.
Topics: Animals; Antibodies, Monoclonal; Bronchoalveolar Lavage Fluid; CD3 Complex; Cyclic N-Oxides; Cytokines; Cytomegalovirus Infections; Lung; Lung Diseases, Interstitial; Male; Mice; Mice, Inbred BALB C; Muromegalovirus; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitrogen Oxides; Polymerase Chain Reaction; Reactive Oxygen Species; RNA, Messenger; Tyrosine; Xanthine Dehydrogenase; Xanthine Oxidase | 1997 |
Thiols and disulphides can aggravate peroxynitrite-dependent inactivation of alpha1-antiproteinase.
Topics: alpha 1-Antitrypsin; Disulfides; Enzyme Activation; Hypochlorous Acid; Nitrates; Sulfhydryl Compounds; Tyrosine | 1997 |
Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.
Topics: Animals; Apoptosis; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Hippocampus; Lipid Peroxidation; Neurons; NF-kappa B; Nitrates; Nitrogen Compounds; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sphingosine; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid | 1997 |
Immunohistochemically detected protein nitration indicates sites of renal nitric oxide release in Goldblatt hypertension.
Topics: Animals; Blood Vessels; Hypertension, Renovascular; Immunohistochemistry; Juxtaglomerular Apparatus; Kidney; Male; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tissue Distribution; Tyrosine | 1997 |
Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite.
Topics: Amyotrophic Lateral Sclerosis; Animals; Binding Sites; Catalysis; Cloning, Molecular; Humans; Kinetics; Liver; Metallothionein; Models, Structural; Mutagenesis, Site-Directed; Mutation; Nitrates; Protein Conformation; Rabbits; Recombinant Proteins; Superoxide Dismutase; Tyrosine; Zinc | 1997 |
Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-L.
Topics: Amino Acid Sequence; Animals; Humans; Kinetics; Mass Spectrometry; Mice; Neurofilament Proteins; Nitrates; Recombinant Proteins; Superoxide Dismutase; Tyrosine | 1997 |
Role of peroxynitrite and activation of poly (ADP-ribose) synthase in the vascular failure induced by zymosan-activated plasma.
Topics: Animals; Aorta; Aorta, Thoracic; Blotting, Western; Cells, Cultured; DNA Damage; Enzyme Activation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Poly(ADP-ribose) Polymerases; Rats; Tyrosine; Zymosan | 1997 |
3-Nitrotyrosine in human serum albumin and low density lipoproteins.
Topics: Humans; Lipoproteins, LDL; Nitrates; Oxidants; Serum Albumin; Tyrosine | 1997 |
Nitration of platelet cytosolic proteins by peroxynitrite.
Topics: Blood Platelets; Blood Proteins; Collagen; Cytosol; Humans; In Vitro Techniques; Membrane Proteins; Nitrates; Oxidants; Tyrosine | 1997 |
Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity.
Topics: Animals; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Immunoenzyme Techniques; Inflammation; Male; Melatonin; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pleurisy; Rats; Rats, Sprague-Dawley; Tyrosine | 1997 |
Peroxynitrite modulates tyrosine-dependent signal transduction pathway of human erythrocyte band 3.
Topics: Amino Acid Sequence; Anion Exchange Protein 1, Erythrocyte; Erythrocytes; Glycolysis; Hemoglobins; Humans; In Vitro Techniques; Molecular Sequence Data; Nitrates; Oxidation-Reduction; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1997 |
Evidence for the production of peroxynitrite in inflammatory CNS demyelination.
Topics: Acute Disease; Animals; Chronic Disease; Encephalomyelitis, Autoimmune, Experimental; Female; Immunohistochemistry; Mice; Mice, Inbred Strains; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Recurrence; Remission Induction; Serum Albumin, Bovine; Spinal Cord; Tyrosine | 1997 |
Scavenging of hydroxyl radicals but not of peroxynitrite by inhibitors and substrates of nitric oxide synthases.
Topics: alpha 1-Antitrypsin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Oxidants; Tyrosine | 1997 |
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Line; Cysteine Endopeptidases; Humans; Intracellular Membranes; Lipid Peroxidation; Membrane Lipids; Mice; Mice, Transgenic; Mitochondria; Neurons; Nitrates; Nitric Oxide; Oxidative Stress; Superoxide Dismutase; Tyrosine | 1998 |
Lipopolysaccharide-induced increase in plasma nitrotyrosine concentrations in rats.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Lipopolysaccharides; Male; Nitrates; Nitrites; Rats; Rats, Wistar; Tyrosine | 1997 |
Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cells, Cultured; Enzyme Inhibitors; Fetus; Free Radical Scavengers; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxidants; Rats; Spinal Cord; Superoxides; Tyrosine | 1998 |
Peroxynitrite formation in focal cerebral ischemia-reperfusion in rats occurs predominantly in the peri-infarct region.
Topics: Animals; Chromatography, High Pressure Liquid; Ischemic Attack, Transient; Male; Nitrates; Rats; Rats, Sprague-Dawley; Reperfusion; Tyrosine | 1998 |
Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues.
Topics: Crystallography, X-Ray; Cysteine; Enzyme Activation; Humans; Immunoblotting; Manganese; Models, Molecular; Nitrates; Oxidation-Reduction; Protein Binding; Superoxide Dismutase; Tyrosine | 1998 |
Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats.
Topics: Aging; Animals; Antioxidants; Biomarkers; Copper; Female; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydroxyl Radical; Nitrates; Nitrogen; Oxidation-Reduction; Oxidative Stress; Proteins; Rats; Serum Albumin, Bovine; Tyrosine | 1998 |
Carbon dioxide stimulates peroxynitrite-mediated nitration of tyrosine residues and inhibits oxidation of methionine residues of glutamine synthetase: both modifications mimic effects of adenylylation.
Topics: Adenosine Monophosphate; Carbon Dioxide; Escherichia coli; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Methionine; Models, Chemical; Models, Molecular; Nitrates; Oxidation-Reduction; Tyrosine | 1998 |
Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis.
Topics: Acute Disease; Adolescent; Adult; Analysis of Variance; Antibodies, Monoclonal; Blotting, Western; Colitis, Ulcerative; Colon; Enzyme Induction; Female; Humans; Immunohistochemistry; Intestinal Mucosa; Isoenzymes; Male; Middle Aged; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 1998 |
Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation?
Topics: Antioxidants; Caffeic Acids; Chlorogenic Acid; Chromans; Chromatography, High Pressure Liquid; Coumaric Acids; Free Radical Scavengers; Free Radicals; Nitrates; Spectrophotometry; Tyrosine | 1998 |
Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia.
Topics: Bronchopulmonary Dysplasia; Female; Humans; Infant, Newborn; Infant, Premature; Male; Nitrates; Oxidants; Oxidative Stress; Pilot Projects; Retrospective Studies; Tyrosine | 1998 |
Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma.
Topics: Antioxidants; Bilirubin; Blood Proteins; Carbon Dioxide; Fluorescence; Humans; Hydrogen-Ion Concentration; Nitrates; Oxidation-Reduction; Peroxides; Sodium Bicarbonate; Spectrophotometry; Tryptophan; Tyrosine | 1998 |
Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.
Topics: Animals; Creatine Kinase; Cytokines; Dexamethasone; Disease Models, Animal; Dogs; Guanidines; Heart; Hemodynamics; Histocytochemistry; Inflammation; Interleukin-1; Isoenzymes; Leukocyte Count; Microspheres; Myocardium; Nitrates; Nitric Oxide; Peroxidase; Tyrosine; Ventricular Dysfunction, Left | 1998 |
Nitric oxide production and perivascular tyrosine nitration following focal ischemia in neonatal rat.
Topics: Animals; Animals, Newborn; Brain; Cell Death; Female; Immunoenzyme Techniques; Ischemic Attack, Transient; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 1998 |
Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Mass Spectrometry; Mitochondria; Molecular Sequence Data; Nitrates; Peptide Fragments; Recombinant Proteins; Sequence Analysis; Serine Endopeptidases; Superoxide Dismutase; Tyrosine | 1998 |
Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Biotransformation; Liver; Male; Mice; Nitrates; Nitric Oxide; Proteins; Tyrosine | 1998 |
Effects of nitration and amination of tyrosyl residues in thermolysin on its hydrolytic activity and its remarkable activation by salts.
Topics: Amination; Dipeptides; Hot Temperature; Hydrolysis; Kinetics; Nitrates; Sodium Chloride; Thermolysin; Tyrosine | 1998 |
Increased nitric oxide in nasal lavage fluid and nitrotyrosine formation in nasal mucosa--indices for severe perennial nasal allergy.
Topics: Adult; Cyclic GMP; Hemoglobins; Humans; Nasal Lavage Fluid; Nasal Mucosa; Nitrates; Nitric Oxide; Nitrites; Rhinitis, Allergic, Perennial; Tyrosine | 1998 |
Modification of tissue factor by peroxynitrite influences its procoagulant activity.
Topics: Coagulants; Membrane Proteins; Monocytes; Nitrates; Oxidants; Recombinant Proteins; Thromboplastin; Tyrosine | 1998 |
Asbestos inhalation induces reactive nitrogen species and nitrotyrosine formation in the lungs and pleura of the rat.
Topics: Animals; Asbestos, Crocidolite; Asbestos, Serpentine; Bronchoalveolar Lavage; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Inhalation Exposure; Lung; Macrophages; Macrophages, Alveolar; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Dioxide; Pleura; Pleural Effusion; Rats; Rats, Inbred F344; Reactive Oxygen Species; Tyrosine | 1998 |
Peroxynitrite uncloaked?
Topics: Free Radicals; Hydrogen-Ion Concentration; Isomerism; Kinetics; Nitrates; Oxidants; Tyrosine | 1998 |
Evidence for in vivo peroxynitrite production in human chronic hepatitis.
Topics: Adult; Antibodies; Antibody Specificity; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Immunohistochemistry; Liver Cirrhosis; Male; Middle Aged; Nitrates; Tyrosine | 1998 |
Nitration of the low molecular weight neurofilament is equivalent in sporadic amyotrophic lateral sclerosis and control cervical spinal cord.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Blotting, Western; Humans; Isoelectric Focusing; Middle Aged; Neurofilament Proteins; Nitrates; Precipitin Tests; Spinal Cord; Tyrosine | 1998 |
Neopterin derivatives modulate the nitration of tyrosine by peroxynitrite.
Topics: Hydrogen-Ion Concentration; Neopterin; Nitrates; Nitro Compounds; Pteridines; Pterins; Spectrophotometry; Tyrosine | 1998 |
Peroxynitrite formation within the central nervous system in active multiple sclerosis.
Topics: Central Nervous System; Humans; Immunohistochemistry; Inflammation; Multiple Sclerosis; Nervous System Diseases; Nitrates; Nitrites; Recurrence; Tyrosine | 1998 |
Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide.
Topics: Animals; Catalase; Catalysis; Horseradish Peroxidase; Hydrogen Peroxide; Hypochlorous Acid; Male; Myocardium; Nitrates; Nitrites; Peroxidase; Rats; Serum Albumin, Bovine; Tyrosine | 1998 |
Differential sensitivity of the tyrosyl radical of mouse ribonucleotide reductase to nitric oxide and peroxynitrite.
Topics: Animals; Coculture Techniques; DNA Replication; Free Radicals; Hydrogen Peroxide; Macrophage Activation; Macrophages, Peritoneal; Mice; NADPH Oxidases; Nitrates; Nitric Oxide; Ribonucleotide Reductases; Spectrophotometry, Atomic; Tumor Cells, Cultured; Tyrosine | 1998 |
Expression of thioredoxin is enhanced in atherosclerotic plaques and during neointima formation in rat arteries.
Topics: Animals; Arteriosclerosis; Carotid Arteries; Catheterization; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Rats; Rats, Wistar; RNA, Messenger; Thioredoxins; Tumor Cells, Cultured; Tunica Intima; Tyrosine | 1998 |
Reduction of tyrosine nitration after N(omega)-nitro-L-arginine-methylester treatment of mice with traumatic brain injury.
Topics: Animals; Brain Injuries; Cerebral Cortex; Enzyme Inhibitors; Immunohistochemistry; Male; Mice; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Tyrosine | 1998 |
Inhibition of peroxynitrite-mediated tyrosine nitration by a novel pyrrolopyrimidine antioxidant.
Topics: Antioxidants; Erythrocyte Membrane; Humans; Nitrates; Oxidative Stress; Pyrimidines; Pyrrolidines; Tyrosine | 1998 |
Inhaled nitric oxide primes lung macrophages to produce reactive oxygen and nitrogen intermediates.
Topics: Administration, Inhalation; Animals; Antibodies; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Epithelial Cells; Interferon-gamma; Lipopolysaccharides; Lung; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen; Oxidants; Proteins; Pulmonary Alveoli; Reactive Oxygen Species; Superoxides; Tyrosine; Vasodilator Agents | 1998 |
Role of constitutive nitric oxide synthase and peroxynitrite production in a rat model of splanchnic artery occlusion shock.
Topics: Analysis of Variance; Animals; Constriction; Enzyme Inhibitors; Ileum; Immunohistochemistry; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Sprague-Dawley; Shock; Splanchnic Circulation; Tyrosine | 1998 |
Role of peroxynitrite and poly (ADP-ribosyl) synthetase activation in cardiovascular derangement induced by zymosan in the rat.
Topics: Animals; Aortic Diseases; Benzamides; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; Injections, Intraperitoneal; Male; Niacinamide; Nitrates; Oxidants; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Shock, Cardiogenic; Tyrosine; Zymosan | 1998 |
Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2B1; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gas Chromatography-Mass Spectrometry; Microsomes, Liver; NADP; Nitrates; Nitric Oxide; Rats; Rats, Long-Evans; tert-Butylhydroperoxide; Tyrosine | 1998 |
Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Electrochemistry; Female; Free Radical Scavengers; Humans; Male; Nitrates; Nitrites; Oxidation-Reduction; Tyrosine; Uric Acid | 1998 |
Lack of tyrosine nitration by peroxynitrite generated at physiological pH.
Topics: Carbon Dioxide; Free Radicals; Hydrogen-Ion Concentration; Models, Chemical; Molsidomine; Nitrates; Nitrogen Oxides; Spermine; Tyrosine; Xanthine Oxidase | 1998 |
Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation.
Topics: Animals; Apoptosis; Benzamides; Caspase 1; Caspase 3; Caspases; Cell Death; Cells, Cultured; Cysteine Endopeptidases; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Hydrogen Peroxide; Immunohistochemistry; Mice; Nitrates; Nitric Oxide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thymus Gland; Tyrosine | 1998 |
Peroxynitrite is not a major mediator of endothelial cell injury by activated neutrophils in vitro.
Topics: Animals; Antibodies, Monoclonal; Cattle; CD18 Antigens; Cells, Cultured; Coculture Techniques; Deferoxamine; Dimethyl Sulfoxide; Endothelium, Vascular; Humans; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide Synthase; Nitrites; Ornithine; Penicillamine; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Phosphatidylinositol 3-kinase is a target for protein tyrosine nitration.
Topics: Animals; Cell Line; Mice; Molecular Weight; Nitrates; Nitric Oxide Donors; Nitrogen Oxides; Phosphatidylinositol 3-Kinases; Protein Conformation; Proteins; Spermine; Tyrosine | 1998 |
Toxic effects of sulphite in combination with peroxynitrite on neuronal cells.
Topics: Animals; Cell Line; Cell Survival; DNA Fragmentation; Drug Combinations; Neurons; Nitrates; Oxidants; Rats; Sulfites; Tyrosine | 1998 |
Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Blood Proteins; Blotting, Western; Celiac Disease; Enzyme-Linked Immunosorbent Assay; Hemocyanins; Humans; Immunohistochemistry; Mice; Nitrates; Serum Albumin, Bovine; Tyrosine | 1998 |
Superoxide released from neutrophils causes a reduction in nitric oxide gas.
Topics: Animals; Cell Line; Cell Survival; Epithelial Cells; Gases; Humans; Hydrogen-Ion Concentration; Lung; Mice; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; RNA, Messenger; Superoxides; Tyrosine | 1998 |
Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys.
Topics: Anemia, Sickle Cell; Animals; Apoptosis; Blotting, Western; Immunohistochemistry; Kidney; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 1998 |
New aspects in the reaction mechanism of phenol with peroxynitrite: the role of phenoxy radicals.
Topics: Anisoles; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Molecular Structure; Nitrates; Nitrites; Nitrophenols; Oxygen; Phenol; Phenols; Tyrosine | 1998 |
Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase.
Topics: Animals; Cell Division; Cells, Cultured; DNA Damage; Enzyme Inhibitors; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitroarginine; Oxidation-Reduction; Rhodamine 123; Rhodamines; Tyrosine | 1998 |
Inhibition of nitrous acid-dependent tyrosine nitration and DNA base deamination by flavonoids and other phenolic compounds.
Topics: Chromatography, High Pressure Liquid; Deamination; DNA; Flavonoids; Hypoxanthines; Nitrates; Nitrous Acid; Phenols; Spectrophotometry, Ultraviolet; Tyrosine; Xanthines | 1998 |
Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Colitis; Enzyme Inhibitors; Free Radical Scavengers; Guanidines; Immunohistochemistry; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tyrosine | 1998 |
Intra-coronary administration of L-arginine aggravates myocardial stunning through production of peroxynitrite in dogs.
Topics: Analysis of Variance; Animals; Arginine; Chromatography, High Pressure Liquid; Dogs; Enzyme Inhibitors; Female; Immunohistochemistry; Isomerism; Lipid Peroxidation; Male; Malondialdehyde; Microdialysis; Myocardial Contraction; Myocardial Stunning; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Random Allocation; Superoxide Dismutase; Tyrosine | 1998 |
Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Dose-Response Relationship, Drug; Edema; Foot; Free Radical Scavengers; Male; Melatonin; Nitrates; Oxidants; Plasma; Rats; Rats, Wistar; Tyrosine | 1998 |
Pulmonary vascular stress from carbon monoxide.
Topics: Animals; Capillaries; Carbon Monoxide; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Leukocytes; Lung; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Tyrosine; Vascular Diseases | 1999 |
Priming of human neutrophils by peroxynitrite: potential role in enhancement of the local inflammatory response.
Topics: Antioxidants; Blood Proteins; Calcium; Cells, Cultured; Humans; Inflammation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrates; Oxidants; Pyrimidines; Pyrrolidines; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury.
Topics: Adenosine Diphosphate; Animals; Contusions; Female; Laminectomy; Nitrates; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Tyrosine | 1999 |
Specific inhibition of iNOS decreases the intestinal mucosal peroxynitrite level and improves the barrier function after thermal injury.
Topics: Animals; Antioxidants; Bacterial Translocation; Body Surface Area; Burns; Coloring Agents; Enzyme Inhibitors; Female; Intestinal Mucosa; Intestine, Small; Isothiuronium; Liver; Lymph Nodes; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Rats; Rats, Sprague-Dawley; Spleen; Superoxides; Tyrosine | 1998 |
Antioxidant properties of the decarboxylated dimer of aminoethylcysteine ketimine: assessment of its ability to scavenge peroxynitrite.
Topics: alpha 1-Antitrypsin; Amino Acids, Sulfur; Antioxidants; Decarboxylation; Dimerization; Free Radical Scavengers; Humans; Lipoproteins, LDL; Nitrates; Oxidation-Reduction; Tyrosine | 1998 |
Evidence for peroxynitrite formation in the vasculature of women with preeclampsia.
Topics: Adult; Biopsy; Cesarean Section; Endothelium, Vascular; Female; Humans; Hysterectomy; Immunohistochemistry; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxidative Stress; Pre-Eclampsia; Pregnancy; Superoxide Dismutase; Tyrosine | 1999 |
Correlation of serum measures of nitric oxide production with lupus disease activity.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Antinuclear; Blood Sedimentation; Complement C3; Complement C4; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Predictive Value of Tests; Tyrosine | 1999 |
Attenuated acute cardiac rejection in NOS2 -/- recipients correlates with reduced apoptosis.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Coumarins; Cysteine Proteinase Inhibitors; DNA Primers; Enzyme Activation; Gene Expression Regulation, Enzymologic; Graft Rejection; Heart Transplantation; In Situ Nick-End Labeling; Mice; Mice, Inbred CBA; Mice, Knockout; Muscle Fibers, Skeletal; Myocardium; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligopeptides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; RNA, Messenger; Transplantation Immunology; Transplantation, Homologous; Tumor Suppressor Protein p53; Tyrosine | 1999 |
Peroxynitrite induces long-lived tyrosyl radical(s) in oxyhemoglobin of red blood cells through a reaction involving CO2 and a ferryl species.
Topics: Carbon Dioxide; Electron Spin Resonance Spectroscopy; Erythrocytes; Ferric Compounds; Free Radicals; Heme; Hemoglobins; Humans; Hydrogen Peroxide; Iron; Methemoglobin; Metmyoglobin; Nitrates; Oxidants; Oxygen; Oxyhemoglobins; Tyrosine | 1999 |
Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Escherichia coli; Female; Immunohistochemistry; Inflammation; Interferon-gamma; Interleukin-10; Intestinal Mucosa; Intestines; Lipopolysaccharides; Macrophages; Mice; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Shock, Septic; Spermine; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat.
Topics: Acetylcysteine; Animals; Cell Membrane Permeability; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Macrophages, Peritoneal; Male; NAD; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sepsis; Shock; Tyrosine; Zymosan | 1999 |
Peroxynitrite formation during rat hepatic allograft rejection.
Topics: Animals; Blood Transfusion; Enzyme Inhibitors; Graft Rejection; Graft Survival; Liver Transplantation; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Rats; Rats, Inbred ACI; Rats, Inbred Lew; RNA, Messenger; Tacrolimus; Tissue Donors; Transplantation, Homologous; Transplantation, Isogeneic; Tyrosine | 1999 |
The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite.
Topics: Chelating Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Liposomes; Molsidomine; Nitrates; Oxidants; Pentetic Acid; Stereoisomerism; Tyrosine; Vitamin E | 1999 |
Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages.
Topics: Animals; Arteriosclerosis; Coronary Artery Bypass; Coronary Vessels; Cyclooxygenase 2; Graft Survival; Humans; Isoenzymes; Macrophages; Membrane Proteins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Compounds; Prostaglandin-Endoperoxide Synthases; Rabbits; Tyrosine | 1999 |
Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death.
Topics: Apoptosis; CD3 Complex; Cell Division; Cells, Cultured; Dose-Response Relationship, Immunologic; Humans; Immunosuppressive Agents; Lymph Nodes; Lymphocyte Activation; Metalloporphyrins; Monocytes; Nitrates; Nitric Oxide Synthase; Phosphorylation; Proteins; Superoxide Dismutase; T-Lymphocytes; Time Factors; Tyrosine | 1999 |
Detection of 3-nitrotyrosine in human platelets exposed to peroxynitrite by a new gas chromatography/mass spectrometry assay.
Topics: Blood Platelets; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Nitrates; Nitrogen Dioxide; Sensitivity and Specificity; Tyrosine | 1998 |
Nitrate reductase alters 3-nitrotyrosine accumulation and cell cycle progression in LPS + IFN-gamma-stimulated RAW 264.7 cells.
Topics: Animals; Cell Cycle; Cell Line; Enzyme Inhibitors; Flow Cytometry; Free Radicals; Hordeum; Interferon-gamma; Lipopolysaccharides; Mice; Nitrate Reductase; Nitrate Reductases; Nitrates; Nitrites; Transfection; Tyrosine | 1998 |
Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite.
Topics: Animals; Ethanol; Female; Free Radicals; Glycogen; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Nitrates; Oxidants; Oxidative Stress; Oxygen; Perfusion; Rats; Rats, Sprague-Dawley; Tyrosine | 1999 |
A kinetic model of the system: tyrosyl radical-nitrogen oxide-superoxide ion.
Topics: Arteriosclerosis; Free Radicals; Humans; Ions; Lipid Peroxidation; Lipoproteins, LDL; Models, Chemical; Nitrates; Nitrogen Oxides; Superoxides; Tyrosine | 1999 |
Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS Dementia Complex; Brain Chemistry; Female; HIV Infections; HIV-1; Humans; Immunohistochemistry; Interleukin-1; Interleukin-10; Macrophages; Male; Middle Aged; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Superoxide Dismutase; Superoxides; Tyrosine | 1999 |
Anaerobic formation and degradation of toxic aromatic compounds in agricultural and communal sewage deposits.
Topics: Agriculture; Anaerobiosis; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Cresols; Gelatin; Germany; Hydrocarbons, Aromatic; Industrial Waste; Kinetics; Nitrates; Phenol; Phenylacetates; Sewage; Tyrosine | 1999 |
Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia.
Topics: Animals; Azides; Cell Survival; Cells, Cultured; Enzyme Activation; Glutamate Dehydrogenase; Inflammation; Ketoglutarate Dehydrogenase Complex; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Nitrates; Nitric Oxide; Oxidative Stress; Oxidoreductases; Oxygen Consumption; Reactive Oxygen Species; Tyrosine | 1999 |
Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase.
Topics: Angiotensin II; Animals; Carbon Radioisotopes; Cattle; Coronary Vasospasm; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinoprostone; Epoprostenol; Immunohistochemistry; In Vitro Techniques; Intramolecular Oxidoreductases; Nitrates; Oxidants; Potassium Chloride; Prostaglandin Antagonists; Prostaglandin H2; Prostaglandins; Prostaglandins H; Proteins; Tyrosine; Vasoconstriction; Vasodilation | 1999 |
Activation pattern of mitogen-activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epithelium; Glutathione Peroxidase; Hydrogen Peroxide; Liver; Nitrates; Nitric Oxide; Phosphorylation; Rats; Sodium Selenite; Time Factors; Tyrosine | 1999 |
Inhibition of peroxynitrite dependent DNA base modification and tyrosine nitration by the extra virgin olive oil-derived antioxidant hydroxytyrosol.
Topics: Animals; Antioxidants; Cattle; Chronic Disease; DNA; DNA Damage; Humans; Hybrid Cells; Mice; Neuroblastoma; Neurons; Nitrates; Nitric Oxide; Olive Oil; Oxidants; Phenylethyl Alcohol; Plant Oils; Rats; Retina; Superoxides; Tyrosine | 1999 |
In vivo disposition of 3-nitro-L-tyrosine in rats: implications on tracking systemic peroxynitrite exposure.
Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Half-Life; Infusions, Intravenous; Male; Nitrates; Oxidants; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tyrosine | 1999 |
Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine.
Topics: alpha 1-Antitrypsin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Humans; Hypochlorous Acid; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 1999 |
Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants.
Topics: Ascorbic Acid; Catalysis; Free Radical Scavengers; Glutathione; Hydrogen-Ion Concentration; Isomerism; Kinetics; Metalloporphyrins; Nitrates; Oxidants; Oxidation-Reduction; Porphyrins; Reducing Agents; Tyrosine; Uric Acid | 1999 |
Selective nitration of prostacyclin synthase and defective vasorelaxation in atherosclerotic bovine coronary arteries.
Topics: Animals; Arteriosclerosis; Cattle; Coronary Vessels; Cytochrome P-450 Enzyme System; Immunohistochemistry; Intramolecular Oxidoreductases; Nitrates; Prostaglandins; Tyrosine; Vasodilation | 1999 |
Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite.
Topics: Catalytic Domain; Humans; Mutation; Nitrates; Recombinant Proteins; Superoxide Dismutase; Tyrosine | 1999 |
High levels of peroxynitrite are generated in the lungs of irradiated mice given cyclophosphamide and allogeneic T cells. A potential mechanism of injury after marrow transplantation.
Topics: Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Disease Models, Animal; Female; L-Lactate Dehydrogenase; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; T-Lymphocytes; Time Factors; Tyrosine | 1999 |
Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle.
Topics: Aging; Amino Acid Sequence; Animals; Biological Transport; Calcium; Calcium-Transporting ATPases; Cysteine; Endopeptidases; Isoenzymes; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Nitrates; Nitric Oxide; Oxygen; Peptide Fragments; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Sulfhydryl Compounds; Tyrosine | 1999 |
Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a postseparation, on-line reduction column and electrochemical detection: results with various nitrating agents.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hypochlorous Acid; Indicators and Reagents; Molsidomine; Nitrates; Nitrites; Nitrogen Oxides; Serum Albumin, Bovine; Sodium Nitrite; Spectrophotometry, Ultraviolet; Spermine; Tyrosine | 1999 |
Inhibition of GTP binding to Rac2 by peroxynitrite: potential role for tyrosine modification.
Topics: Animals; Binding Sites; Fluorescent Dyes; Free Radicals; GTP-Binding Proteins; Guanosine Triphosphate; In Vitro Techniques; Nitrates; Oxidants; rac GTP-Binding Proteins; Reactive Oxygen Species; Recombinant Proteins; Tyrosine | 1999 |
Inhibition of peroxynitrite-mediated oxidation of dopamine by flavonoid and phenolic antioxidants and their structural relationships.
Topics: Antioxidants; Caffeic Acids; Catechin; Chromatography, High Pressure Liquid; Coumaric Acids; Dopamine; Flavonoids; Monophenol Monooxygenase; Nitrates; Oxidation-Reduction; Phenols; Propionates; Structure-Activity Relationship; Tyrosine | 1999 |
Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation.
Topics: Carbon Dioxide; Escherichia coli; Glutamate-Ammonia Ligase; Glycine max; Hydrogen-Ion Concentration; Kinetics; Lipid Peroxidation; Lipoxygenase; Methionine; Models, Chemical; Nitrates; Oxidants; Oxidation-Reduction; Serum Albumin, Bovine; Tyrosine | 1999 |
The protective role of endogenous glutathione in carrageenan-induced pleurisy in the rat.
Topics: Animals; Carrageenan; Cells, Cultured; Disease Models, Animal; Free Radical Scavengers; Glutathione; Macrophages; Nitrates; Nitric Oxide; Oxidants; Pleurisy; Protective Agents; Rats; Tyrosine | 1999 |
Role of interleukin-6 in a non-septic shock model induced by zymosan.
Topics: Animals; Antibodies, Monoclonal; Ascites; Ascitic Fluid; DNA Damage; Energy Metabolism; Injections, Intraperitoneal; Interleukin-6; Intestine, Small; Leukocyte Count; Lipid Peroxidation; Liver; Lung; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Organ Failure; NAD; Neutrophils; Nitrates; Nitrites; Oxidative Phosphorylation; Peritonitis; Peroxidase; Shock; Tyrosine; Zymosan | 1999 |
Tyrosine nitration in blood vessels occurs with increasing nitric oxide concentration.
Topics: Animals; Aorta, Thoracic; Cattle; In Vitro Techniques; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Rabbits; Superoxides; Tyrosine | 1999 |
p130cas is a cellular target protein for tyrosine nitration induced by peroxynitrite.
Topics: Crk-Associated Substrate Protein; Humans; Molsidomine; Neuroblastoma; Nitrates; Nitric Oxide Donors; Oxidants; Phosphoproteins; Phosphorylation; Proteins; Retinoblastoma-Like Protein p130; Tumor Cells, Cultured; Tyrosine | 1999 |
Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage.
Topics: Animals; Brain; Cerebral Infarction; Citrulline; Corpus Striatum; Enzyme Activation; Functional Laterality; Immunohistochemistry; Injections, Intraperitoneal; Ischemic Attack, Transient; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Microinjections; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidants; Tyrosine | 1999 |
Denitration of peroxynitrite-treated proteins by "protein nitratases" from dog prostate.
Topics: Animals; beta-Fructofuranosidase; Blotting, Western; Dithiothreitol; Dogs; Enzyme Activation; Glutathione Transferase; Glycoside Hydrolases; Histones; Male; Nitrates; Oxidoreductases; Polylysine; Prostate; Serum Albumin; Tissue Extracts; Tyrosine | 1999 |
Peroxynitrite induces tryosine nitration and modulates tyrosine phosphorylation of synaptic proteins.
Topics: Animals; Brain; Brain Chemistry; Cattle; Dose-Response Relationship, Drug; Nitrates; Nitric Oxide; Oxidants; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Synapses; Synaptophysin; Synaptosomes; Tyrosine | 1999 |
Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Coronary Vasospasm; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Hydrazines; Hypoxia; In Vitro Techniques; Indomethacin; Intramolecular Oxidoreductases; Nitrates; Oxygen; Tyrosine | 1999 |
Effects of reactive oxygen and nitrogen metabolites on RANTES- and IL-5-induced eosinophil chemotactic activity in vitro.
Topics: Chemokine CCL5; Chemotaxis; Deferoxamine; Dithiothreitol; Dose-Response Relationship, Drug; Eosinophils; Humans; Hydrazines; Interleukin-5; Leukotriene B4; Molsidomine; Nitrates; Nitric Oxide; Nitrogen; Pteridines; Reactive Oxygen Species; Superoxides; Tyrosine; Xanthine | 1999 |
Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Neurotoxins; Nitrates; Oxidants; Porphyrins; Reference Values; Tyrosine | 1999 |
Radical mechanisms of the decomposition of peroxynitrite and the peroxynitrite-CO(2) adduct and of reactions with L-tyrosine and related compounds as studied by (15)N chemically induced dynamic nuclear polarization.
Topics: Carbon Dioxide; Free Radicals; Magnetic Resonance Spectroscopy; Nitrates; Tyrosine | 1999 |
Protective effects of poly (ADP-ribose) synthase inhibitors in zymosan-activated plasma induced paw edema.
Topics: Animals; Benzamides; Complement Activation; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Free Radicals; Immunohistochemistry; Inflammation; Male; Niacinamide; Nitrates; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine; Zymosan | 1999 |
Effects of exogenous nitric oxide and hyperoxia on lung fibroblast viability and DNA fragmentation.
Topics: Antioxidants; Catalase; Cell Survival; Cells, Cultured; DNA Fragmentation; Fibroblasts; Humans; Hyperoxia; In Situ Nick-End Labeling; Lung; Nitrates; Nitric Oxide; Oxygen; Superoxides; Tyrosine | 1999 |
Formation and loss of nitrated proteins in peroxynitrite-treated rat skin in vivo.
Topics: Animals; Kinetics; Male; Nitrates; Oxidants; Proteins; Rats; Rats, Wistar; Serum Albumin, Bovine; Skin; Time Factors; Tyrosine | 1999 |
Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis.
Topics: Animals; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Free Radical Scavengers; Inflammation; Intracranial Pressure; Leukocytes; Male; Meningitis, Pneumococcal; Nitrates; Oxidants; Rats; Rats, Wistar; Subarachnoid Space; Tyrosine; Uric Acid | 1999 |
Effects of reactive oxygen and nitrogen metabolites on MCP-1-induced monocyte chemotactic activity in vitro.
Topics: Blood Physiological Phenomena; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; Leukotriene B4; Monocytes; Nitrates; Nitrogen; Oxidants; Reactive Oxygen Species; Reducing Agents; Superoxides; Tyrosine | 1999 |
Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite.
Topics: Aniline Compounds; Anions; Dithiothreitol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Leukocyte Common Antigens; Models, Molecular; Molsidomine; Nitrates; Nitric Oxide; Nitroso Compounds; Organophosphates; Organophosphorus Compounds; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; S-Nitrosoglutathione; Superoxide Dismutase; Tyrosine | 1999 |
Vascular peroxynitrite formation during organic nitrate tolerance.
Topics: Animals; Aorta, Thoracic; Blood Proteins; Drug Tolerance; Immunohistochemistry; Male; Nitrates; Nitroglycerin; Rats; Rats, Sprague-Dawley; Tyrosine; Vasodilator Agents | 1999 |
IL-6 knock-out mice exhibit resistance to splanchnic artery occlusion shock.
Topics: Animals; Antibodies, Monoclonal; Arterial Occlusive Diseases; Celiac Artery; Constriction; Cytokines; Ileum; Immunity, Innate; Intercellular Adhesion Molecule-1; Interleukin-6; Ischemia; Leukocyte Count; Lipid Peroxidation; Malondialdehyde; Mesenteric Artery, Superior; Mice; Mice, Knockout; Neutrophils; Nitrates; Nitric Oxide; P-Selectin; Peroxidase; Reperfusion Injury; Shock; Splanchnic Circulation; Tyrosine | 1999 |
In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders.
Topics: Aldehydes; Alzheimer Disease; Analysis of Variance; Biomarkers; DNA Damage; Glycation End Products, Advanced; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Histocytochemistry; Humans; Iron; Membrane Proteins; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Nitrates; Oxidation-Reduction; Oxidative Stress; Oxygen; Phenylhydrazines; Plaque, Amyloid; Tyrosine | 1999 |
Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination.
Topics: Adolescent; Adult; Aged; Biomarkers; Bronchoalveolar Lavage Fluid; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Hydroxyl Radical; Hydroxylation; Hypochlorous Acid; Linear Models; Male; Middle Aged; Neutrophil Activation; Neutrophils; Nitrates; Oxidants; Oxidative Stress; Proteins; Respiration, Artificial; Respiratory Distress Syndrome; Statistics, Nonparametric; Tyrosine | 1999 |
Sensitivity of the yellow variant of green fluorescent protein to halides and nitrate.
Topics: Amino Acid Substitution; Bromides; Chlorides; Green Fluorescent Proteins; Hydrogen-Ion Concentration; Indicators and Reagents; Iodides; Luminescent Proteins; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Nitrates; Oxidation-Reduction; Tyrosine | 1999 |
Inhibitory mechanism of sinapinic acid against peroxynitrite-mediated tyrosine nitration of protein in vitro.
Topics: Chromatography, High Pressure Liquid; Coumaric Acids; Dimerization; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nitrates; Oxidation-Reduction; Proteins; Tyrosine | 1999 |
Increased expression of inducible nitric oxide synthase and peroxynitrite in Helicobacter pylori gastric ulcer.
Topics: Fluorescent Antibody Technique; Gastric Mucosa; Gastritis; Helicobacter pylori; Humans; Macrophages; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptic Ulcer; Tyrosine | 1999 |
Effects of reactive oxygen species on brain synaptic plasma membrane Ca(2+)-ATPase.
Topics: Age Factors; Amidines; Animals; Azo Compounds; Brain; Calcium; Calcium-Transporting ATPases; Hydrogen Peroxide; Kinetics; Male; Nitrates; Oxidative Stress; Phenylhydrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Synaptic Membranes; Tyrosine; Urea; Valerates | 1999 |
Endothelial cell nitric oxide production in acute chest syndrome.
Topics: Animals; Blood Physiological Phenomena; Cattle; Cells, Cultured; Endothelium, Vascular; Glutathione; Hemoglobin SC Disease; Humans; Lung Diseases; Mercaptoethanol; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroso Compounds; RNA, Messenger; S-Nitrosothiols; Sulfhydryl Compounds; Tyrosine | 1999 |
Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase.
Topics: Animals; Blood Circulation; Cattle; Cells, Cultured; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Nitrates; Nitric Oxide; Signal Transduction; Superoxides; Tyrosine | 1999 |
Role of IL-6 in the pleurisy and lung injury caused by carrageenan.
Topics: Animals; Carrageenan; Cells, Cultured; Cytokines; Dinoprostone; DNA Damage; Enzyme Induction; Interleukin-6; Leukotriene B4; Lung; Macrophages; Male; Malondialdehyde; Mice; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Pleura; Pleurisy; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Prostaglandins F; Tyrosine | 1999 |
Modification of proteins and polynucleotides by peroxynitrite.
Topics: Animals; Nitrates; Nitric Oxide; Oxidants; Proteins; Rabbits; Tyrosine | 1999 |
Role of superoxide anion in the pathogenesis of cytokine-induced myocardial dysfunction in dogs in vivo.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Dogs; Echocardiography; Female; Interleukin-1; Male; Myocardium; Nitrates; Random Allocation; Stroke Volume; Superoxides; Thiazoles; Tyrosine; Ventricular Dysfunction, Left | 1999 |
The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat.
Topics: Animals; Carrageenan; Cells, Cultured; Energy Metabolism; Lipid Peroxidation; Macrophages; Melatonin; Nitrates; Nitric Oxide; Peroxidase; Pleurisy; Rats; Tyrosine | 1999 |
Factors determining the selectivity of protein tyrosine nitration.
Topics: Amino Acid Sequence; Models, Molecular; Molecular Sequence Data; Muramidase; Nitrates; Nitric Oxide; Phospholipases A; Protein Processing, Post-Translational; Protein Structure, Secondary; Ribonuclease, Pancreatic; Sequence Analysis, Protein; Superoxides; Tyrosine | 1999 |
Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivo.
Topics: Apolipoprotein B-100; Apolipoproteins B; Humans; Lipid Peroxides; Lipoproteins, LDL; Monocytes; Nitrates; Nitric Oxide; Oxidants; Peroxidase; Tyrosine | 1999 |
Immunohistochemical nitrotyrosine distribution in neonatal rat cerebrocortical slices during and after hypoxia.
Topics: Animals; Brain; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hypoxia-Ischemia, Brain; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Superoxides; Tyrosine | 1999 |
Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan.
Topics: Animals; Antioxidants; Disease Models, Animal; Exudates and Transudates; Immunohistochemistry; Kidney; Lipid Peroxidation; Liver; Lung; Male; Malondialdehyde; Melatonin; Nitrates; Rats; Rats, Sprague-Dawley; Shock; Tyrosine; Zymosan | 1999 |
Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acids; Animals; Brain; Chelating Agents; Dopamine Agents; Free Radicals; Gas Chromatography-Mass Spectrometry; Male; Mice; Mice, Inbred C57BL; Nitrates; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Pentetic Acid; Tissue Distribution; Tyrosine | 1999 |
Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration.
Topics: Bicarbonates; Enzyme Activation; Nitrates; Oxidants; Oxidation-Reduction; Pyrimidines; Pyrroles; Sulfhydryl Compounds; Tetranitromethane; Tyrosine; Tyrosine 3-Monooxygenase | 1999 |
Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Immunohistochemistry; L-Lactate Dehydrogenase; Lung; Male; Malondialdehyde; Metalloporphyrins; NAD; Nitrates; Peroxidase; Rats; Rats, Sprague-Dawley; Shock; Superoxide Dismutase; Tyrosine; Zymosan | 1999 |
Protection against peroxynitrite by cocoa polyphenol oligomers.
Topics: Biflavonoids; Cacao; Catechin; Flavonoids; Nitrates; Oxidants; Oxidation-Reduction; Phenols; Polymers; Proanthocyanidins; Protective Agents; Rhodamines; Tyrosine | 1999 |
NOX, a novel nitric oxide scavenger, reduces bacterial translocation in rats after endotoxin challenge.
Topics: Animals; Bacteremia; Enterobacteriaceae; Enterocytes; Free Radical Scavengers; Infusion Pumps, Implantable; Intestinal Absorption; Intestines; Lipopolysaccharides; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Thiocarbamates; Tyrosine | 1999 |
Denitration of peroxynitrite-treated proteins by 'protein nitratases' from rat brain and heart.
Topics: Animals; beta-Fructofuranosidase; Blotting, Western; Brain; Brain Chemistry; Calcium; Dialysis; Enzymes; Flavin-Adenine Dinucleotide; Glutathione; Glutathione Transferase; Glycoside Hydrolases; Myocardium; NAD; NADP; Nitrates; Proteins; Rats; Serum Albumin, Bovine; Tissue Extracts; Tyrosine | 1999 |
Peroxynitrite irreversibly decreases diastolic and systolic function in cardiac muscle.
Topics: Animals; Diastole; Immunoenzyme Techniques; Male; Myocardial Contraction; Nitrates; Oxidants; Papillary Muscles; Rats; Systole; Tyrosine | 1999 |
Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts.
Topics: Adult; Artifacts; Blood Proteins; Gas Chromatography-Mass Spectrometry; Humans; Male; Nitrates; Tyrosine | 2000 |
Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex.
Topics: Animals; Blotting, Western; Calcium; Cerebral Cortex; Chronic Disease; Glutamic Acid; Immunohistochemistry; L-Lactate Dehydrogenase; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Restraint, Physical; Stress, Physiological; Synaptosomes; Tyrosine | 2000 |
Tyrosine nitration by simultaneous generation of (.)NO and O-(2) under physiological conditions. How the radicals do the job.
Topics: Animals; Free Radicals; Humans; Nitrates; Tyrosine | 2000 |
Endothelial dysfunction and peroxynitrite formation are early events in angiotensin-induced cardiovascular disorders.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta, Thoracic; Cardiovascular Diseases; Endothelium, Vascular; Hemodynamics; Image Processing, Computer-Assisted; Immunohistochemistry; In Vitro Techniques; Male; Nitrates; Nitroprusside; Phenylephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Renin; Tyrosine; Vasoconstriction | 2000 |
Nitrotyrosine generation via inducible nitric oxide synthase in vascular wall in focal ischemia-reperfusion.
Topics: Acidosis; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Endothelium, Vascular; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Reperfusion Injury; Tyrosine | 2000 |
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite. Implications for tyrosine modification by nitric oxide/superoxide in vivo.
Topics: Dimerization; Flavin Mononucleotide; Free Radicals; Hydrazines; Hypoxanthine; Kinetics; Nitrates; Nitric Oxide; Nitrogen Oxides; Spermine; Tyrosine; Xanthine Oxidase | 2000 |
Role of nitric oxide and peroxynitrite in bile salt-induced apoptosis: relevance to colon carcinogenesis.
Topics: Apoptosis; Bile Acids and Salts; Colonic Neoplasms; Deoxycholic Acid; Enzyme Inhibitors; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Salicylates; Superoxides; Tumor Cells, Cultured; Tyrosine | 1999 |
Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice.
Topics: Acetaminophen; Adjuvants, Immunologic; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cattle; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Hemocyanins; Immunoenzyme Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Nitrates; Protein Binding; Proteins; Rabbits; Serum Albumin, Bovine; Sodium Chloride; Tyrosine | 2000 |
Scavengers for peroxynitrite: inhibition of tyrosine nitration and oxidation with tryptamine derivatives, alpha-lipoic acid and synthetic compounds.
Topics: Antioxidants; Chromatography, High Pressure Liquid; DNA Damage; Free Radical Scavengers; Indicators and Reagents; Nitrates; Oxidation-Reduction; Plasmids; Spectrophotometry, Ultraviolet; Spin Trapping; Thioctic Acid; Tryptamines; Tyrosine | 2000 |
Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy.
Topics: Animals; Carrageenan; Cells, Cultured; Cyclic N-Oxides; DNA Damage; Free Radical Scavengers; Hydrogen Peroxide; Lung; Macrophages; Male; Mitochondria; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxygen Consumption; Permeability; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Spin Labels; Tyrosine | 2000 |
Rapid reactions of peroxynitrite with heme-thiolate proteins as the basis for protection of prostacyclin synthase from inactivation by nitration.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hemeproteins; Horseradish Peroxidase; Intramolecular Oxidoreductases; Kinetics; Models, Biological; Nitrates; Tyrosine | 2000 |
Diffusion of peroxynitrite into the human platelet inhibits cyclooxygenase via nitration of tyrosine residues.
Topics: Blood Platelets; Cell Membrane; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diffusion; Eicosanoids; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; In Vitro Techniques; Indicators and Reagents; Isoenzymes; Membrane Proteins; Nitrates; Oxidants; Platelet Activation; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Tyrosine; Vasoconstriction | 2000 |
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Free Radical Scavengers; Mice; Multiple Sclerosis; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Spinal Cord; Tyrosine; Uric Acid | 2000 |
Responses to peroxynitrite in yeast: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a sensitive intracellular target for nitration and enhancement of chaperone expression and ubiquitination.
Topics: Animals; Astrocytes; Cell Culture Techniques; Cell Survival; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Fungal Proteins; Glyceraldehyde-3-Phosphate Dehydrogenases; HSP70 Heat-Shock Proteins; Hydrogen Peroxide; Molecular Chaperones; Nitrates; Oxidants; Rats; Rats, Wistar; Saccharomyces cerevisiae; Sulfhydryl Compounds; Sulfhydryl Reagents; Tyrosine; Ubiquitins; Up-Regulation | 2000 |
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies.
Topics: alpha-Synuclein; Electrophoresis, Polyacrylamide Gel; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitrates; Oxidative Stress; Polymers; Recombinant Proteins; Synucleins; Tyrosine | 2000 |
Role of peroxynitrite in altered fetal-placental vascular reactivity in diabetes or preeclampsia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Angiotensin II; Antihypertensive Agents; Diabetes Mellitus, Type 1; Epoprostenol; Female; Fetus; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitroglycerin; Oxidative Stress; Placenta; Pre-Eclampsia; Pregnancy; Reactive Oxygen Species; Tyrosine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
Increased production of nitrotyrosine in lung tissue of rats with radiation-induced acute lung injury.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Enzyme Induction; L-Lactate Dehydrogenase; Lung; Lung Diseases; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Proteins; Radiation Injuries, Experimental; Rats; Rats, Wistar; Tyrosine | 2000 |
Reactive nitrogen and oxygen species attenuate interleukin- 8-induced neutrophil chemotactic activity in vitro.
Topics: Chemotaxis, Leukocyte; Humans; Interleukin-8; Leukotriene B4; Molsidomine; Neutrophils; Nitrates; Nitric Oxide Donors; Tyrosine | 2000 |
Involvement of peroxynitrite and hydroxyradical generated from nitric oxide in hypoxia/reoxygenation injury in rat cerebrocortical slices.
Topics: Adenosine Triphosphate; Animals; Cell-Free System; Cerebral Cortex; Cyclic AMP; Enzyme Inhibitors; Hydroxyl Radical; Hypoxia; Male; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salicylates; Tyrosine | 2000 |
Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases.
Topics: Adult; Aged; Alzheimer Disease; Antibodies; Biomarkers; Female; Humans; Male; Middle Aged; Nitrates; Nitrogen; Oxidative Stress; Parkinson Disease; Precipitin Tests; Superoxide Dismutase; Tyrosine | 2000 |
Peroxynitrite-mediated nitration of the stable free radical tyrosine residue of the ribonucleotide reductase small subunit.
Topics: Amino Acid Sequence; Catalysis; Chromatography, High Pressure Liquid; Conserved Sequence; Dimerization; Dose-Response Relationship, Drug; Escherichia coli; Free Radicals; Hydrogen-Ion Concentration; Mass Spectrometry; Models, Molecular; Molecular Weight; Nitrates; Nonheme Iron Proteins; Protein Structure, Quaternary; Ribonucleotide Reductases; Sequence Analysis, Protein; Spectrophotometry; Tyrosine | 2000 |
Hyperalgesia due to nerve injury-role of peroxynitrite.
Topics: Animals; Hyperalgesia; Hyperthermia, Induced; Immunohistochemistry; Male; Nerve Compression Syndromes; Nerve Crush; Nerve Degeneration; Neuralgia; Nitrates; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Rats, Wistar; Tyrosine; Uric Acid | 2000 |
Formation of N-nitrosamines and N-nitramines by the reaction of secondary amines with peroxynitrite and other reactive nitrogen species: comparison with nitrotyrosine formation.
Topics: Aniline Compounds; Hydrogen Peroxide; Hypochlorous Acid; Morpholines; Nitrates; Nitrobenzenes; Nitrosamines; Sodium Nitrite; Superoxides; Tyrosine | 2000 |
Role of the carbonate radical anion in tyrosine nitration and hydroxylation by peroxynitrite.
Topics: Anions; Bicarbonates; Carbon Dioxide; Carbonates; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen-Ion Concentration; Hydroxyl Radical; Hydroxylation; Kinetics; Nitrates; Nitric Oxide; Spectrophotometry, Ultraviolet; Tyrosine | 2000 |
Plasma proteins modified by tyrosine nitration in acute respiratory distress syndrome.
Topics: Acute Disease; Adult; alpha 1-Antichymotrypsin; Blood Proteins; Blotting, Western; Carbon Dioxide; Ceruloplasmin; Enzyme Activation; Fibrinogen; Humans; In Vitro Techniques; Nitrates; Nitric Oxide; Oxidative Stress; Precipitin Tests; Respiratory Distress Syndrome; Superoxides; Tyrosine | 2000 |
Carbon dioxide enhances nitration of surfactant protein A by activated alveolar macrophages.
Topics: Carbon Dioxide; Cells, Cultured; Enzyme Activation; Epithelial Cells; Humans; Hypercapnia; Lipid Metabolism; Lipopolysaccharides; Macrophages, Alveolar; Mass Spectrometry; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Respiratory Distress Syndrome; Tyrosine | 2000 |
Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy.
Topics: Adolescent; Adult; Aged; Child; Diabetic Nephropathies; Female; Humans; Immunohistochemistry; Kidney; Male; Middle Aged; Nitrates; Tyrosine | 2000 |
Bicarbonate enhances the hydroxylation, nitration, and peroxidation reactions catalyzed by copper, zinc superoxide dismutase. Intermediacy of carbonate anion radical.
Topics: Animals; Anions; Bicarbonates; Catalysis; Cations; Cattle; Cyclic N-Oxides; Free Radicals; Hydrogen Peroxide; Hydroxylation; Nitrates; Spin Labels; Superoxide Dismutase; Tyrosine | 2000 |
The nitration of platelet cytosolic proteins during agonist-induced activation of platelets.
Topics: Aspirin; Blood Platelets; Blood Proteins; Blotting, Western; Cell Adhesion Molecules; Collagen; Cyclooxygenase Inhibitors; Cytosol; Enzyme-Linked Immunosorbent Assay; Humans; Membrane Proteins; Microfilament Proteins; Molecular Weight; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrous Acid; Oxidants; Peroxynitrous Acid; Phosphoproteins; Platelet Activation; Thrombin; Tyrosine | 2000 |
A catalyst of peroxynitrite decomposition inhibits murine experimental autoimmune encephalomyelitis.
Topics: Animals; Catalysis; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Female; Ferric Compounds; Immunohistochemistry; Lymphocyte Transfusion; Lymphocytes; Metalloporphyrins; Mice; Mice, Inbred Strains; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 2000 |
Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney.
Topics: Animals; Blood Urea Nitrogen; Blotting, Western; Creatine; Enzyme Inhibitors; Glutathione; Immunohistochemistry; Kidney; Lipid Peroxidation; Lipopolysaccharides; Lysine; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis; Female; Male; Motor Activity; Neurologic Examination; Neuroprotective Agents; Neutrophils; Nitrates; Poly(ADP-ribose) Polymerase Inhibitors; Polymers; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Stroke; Time Factors; Tyrosine | 2000 |
Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis.
Topics: Adult; Alternative Splicing; Arginine; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; DNA-Binding Proteins; Epithelial Cells; Female; Fluocinolone Acetonide; Humans; Interferon-gamma; Janus Kinase 1; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Reactive Oxygen Species; RNA, Messenger; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Tyrosine | 2000 |
Scavenging of peroxynitrite by oxyhemoglobin and identification of modified globin residues.
Topics: Ascorbic Acid; Carbon Dioxide; Dipeptides; Erythrocytes; Free Radical Scavengers; Globins; Humans; Immunoelectrophoresis; Mass Spectrometry; Nitrates; Oxyhemoglobins; Tyrosine | 2000 |
Oxygen-insensitive nitroreductases of Escherichia coli do not reduce 3-nitrotyrosine.
Topics: Bacterial Proteins; Cell Fractionation; Drug Resistance, Neoplasm; Enzyme Induction; Escherichia coli; Escherichia coli Proteins; Nitrates; Nitroreductases; Oxidation-Reduction; Oxygen; Paraquat; Peptides; Reducing Agents; Tyrosine | 2000 |
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion.
Topics: Animals; Blood Pressure; Catalysis; Celiac Artery; Disease Models, Animal; Endothelium, Vascular; Ferric Compounds; Ileum; Intercellular Adhesion Molecule-1; Leukocyte Count; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhodamines; Splanchnic Circulation; Tyrosine | 2000 |
Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinoma.
Topics: Adenocarcinoma; Blotting, Western; Chromatography, High Pressure Liquid; Cortactin; Humans; Microfilament Proteins; Nitrates; Pancreatic Neoplasms; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Conformation; Protein Folding; Proto-Oncogene Proteins pp60(c-src); Tumor Cells, Cultured; Tyrosine | 2000 |
Protein nitration, metabolites of reactive nitrogen species, and inflammation in lung allografts.
Topics: Adult; Bronchiolitis Obliterans; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Female; Forced Expiratory Volume; Graft Rejection; Humans; Lung; Lung Transplantation; Male; Nitrates; Nitrites; Postoperative Complications; Prognosis; Tyrosine | 2000 |
Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage.
Topics: Albumins; Animals; Coenzymes; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Immunoblotting; Kinetics; Mitochondria; Mitochondria, Liver; Models, Chemical; Nitrates; Oxidation-Reduction; Oxidative Stress; Oxygen; Oxygen Consumption; Protein Binding; Rats; Spectrophotometry; Time Factors; Tyrosine; Ubiquinone | 2000 |
Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice.
Topics: Animals; Antibiotics, Antineoplastic; Creatine Kinase; Doxorubicin; Immunohistochemistry; Male; Mice; Myocardium; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine; Ventricular Dysfunction, Left | 2000 |
Peroxynitrite-generating species: good candidate oxidants in aqueous extracts of cigarette smoke.
Topics: Arteriosclerosis; Humans; Nicotiana; Nitrates; Oxidants; Plants, Toxic; Smoke; Smoking; Tyrosine | 2000 |
Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys.
Topics: Alanine Transaminase; Anemia, Sickle Cell; Animals; Apoptosis; Aspartate Aminotransferases; Blotting, Western; Cell Hypoxia; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Guanidines; Immunohistochemistry; In Situ Nick-End Labeling; Kidney Diseases; Kidney Tubules; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Poly(ADP-ribose) Polymerases; Tyrosine | 2000 |
Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock.
Topics: Animals; Blood Pressure; Cyclic N-Oxides; Free Radical Scavengers; Kidney; Lipopolysaccharides; Liver; Lung; Male; Multiple Organ Failure; Multiple Trauma; Nitrates; Nitrites; Peptidoglycan; Random Allocation; Rats; Rats, Wistar; Shock, Septic; Spin Labels; Staphylococcal Infections; Teichoic Acids; Tyrosine | 2000 |
Helicobacter pylori urease suppresses bactericidal activity of peroxynitrite via carbon dioxide production.
Topics: Ammonia; Anti-Bacterial Agents; Carbon Dioxide; Drug Interactions; Helicobacter pylori; Microbial Sensitivity Tests; Nitrates; Oxidants; Sodium Bicarbonate; Tyrosine; Urea; Urease | 2000 |
Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase.
Topics: Humans; Kinetics; Nitrates; Nitric Oxide; Oxidants; Peroxidase; Sputum; Superoxides; Tyrosine; Xanthine Oxidase | 2000 |
Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite.
Topics: Hydrogen-Ion Concentration; Kinetics; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxidants; Photochemistry; Spectrophotometry; Spermine; Superoxides; Tyrosine; Xanthine Oxidase | 2000 |
Reactions of peroxynitrite with cocoa procyanidin oligomers.
Topics: Biflavonoids; Cacao; Catechin; Chromatography, High Pressure Liquid; Drug Interactions; Nitrates; Oxidants; Oxidation-Reduction; Proanthocyanidins; Rhodamines; Structure-Activity Relationship; Tyrosine | 2000 |
Elevation of nitrotyrosine and nitrate concentrations in cystic fibrosis sputum.
Topics: Adolescent; Adult; Cystic Fibrosis; Female; Free Radicals; Humans; Inflammation; Male; Nitrates; Nitric Oxide; Sputum; Superoxides; Tyrosine | 2000 |
Immunolocalization of inducible nitric oxide synthase and 3-nitrotyrosine in the nasal mucosa of patients with rhinitis.
Topics: Adolescent; Adult; Enzyme Induction; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Nasal Mucosa; Nitrates; Nitric Oxide Synthase; Rhinitis; Rhinitis, Allergic, Perennial; Turbinates; Tyrosine | 2000 |
Physiological effects of peroxynitrite: potential products of the environment.
Topics: Animals; Blood Physiological Phenomena; Cats; Crystalloid Solutions; Cytokines; Glutathione; Heart; Heart Diseases; Heart Ventricles; Humans; Isotonic Solutions; Myocardial Infarction; Nitrates; Nitric Oxide; Perfusion; Plasma Substitutes; Superoxides; Tyrosine | 2000 |
Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia.
Topics: Animals; Biomarkers; Blood-Brain Barrier; Coloring Agents; Endothelium, Vascular; Enzyme Inhibitors; Evans Blue; Indazoles; Infarction, Middle Cerebral Artery; Matrix Metalloproteinase 9; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxidants; Permeability; Reperfusion Injury; Tyrosine | 2000 |
Immature brain injury via peroxynitrite production induced by inducible nitric oxide synthase after hypoxia-ischemia in rats.
Topics: Animals; Animals, Newborn; Brain Diseases; Carotid Arteries; Hypoxia-Ischemia, Brain; Kinetics; Ligation; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2000 |
Proteolytic degradation of tyrosine nitrated proteins.
Topics: Animals; Cattle; Chymotrypsin; Cysteine Endopeptidases; Endopeptidases; In Vitro Techniques; Kinetics; Multienzyme Complexes; Nitrates; PC12 Cells; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Proteins; Rats; Superoxide Dismutase; Tyrosine; Tyrosine 3-Monooxygenase | 2000 |
Nitric oxide synthase and tissue injury.
Topics: Alprostadil; Animals; Arginine; Burns; Enzyme Inhibitors; Humans; Ischemia; Luminescent Measurements; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Reperfusion Injury; Sepsis; Shock; Superoxides; Tyrosine | 2000 |
Drip and ship: a new strategy for the treatment of acute coronary syndromes.
Topics: Abciximab; Acute Disease; Adult; Aged; Aged, 80 and over; Angina, Unstable; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clinical Protocols; Coronary Angiography; Coronary Disease; Electrocardiography; Female; Fibrinolytic Agents; Heparin; Hospitalization; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Nitrates; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tirofiban; Treatment Outcome; Tyrosine | 2000 |
Myeloperoxidase and protein oxidation in cystic fibrosis.
Topics: Adult; Bronchi; Case-Control Studies; Cell Line; Chromatography, High Pressure Liquid; Cystic Fibrosis; Drug Synergism; Humans; Hydrogen Peroxide; Nitrates; Nitrites; Oxidants; Oxidation-Reduction; Peroxidase; Peroxidases; Proteins; Respiratory System; Sputum; Trachea; Tyrosine | 2000 |
Potentiation of carbachol-induced Ca2+ release by peroxynitrite in human neuroblastoma SH-SY5Y cells.
Topics: Calcium; Carbachol; Genistein; Humans; Molsidomine; Neuroblastoma; Nitrates; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2000 |
P-selectin participates in cardiopulmonary bypass-induced inflammatory response in association with nitric oxide and peroxynitrite production.
Topics: Animals; Antibodies, Monoclonal; Cardiopulmonary Bypass; Inflammation; Interleukin-6; Male; Nitrates; Nitric Oxide; Nitrites; P-Selectin; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury.
Topics: Acetylcholine; Acetylcysteine; Analysis of Variance; Animals; Aorta; Fluorescent Antibody Technique, Indirect; Free Radical Scavengers; Ileum; In Vitro Techniques; Intercellular Adhesion Molecule-1; Leukocyte Count; Lipid Peroxidation; Male; Malondialdehyde; Nitrates; Nitrites; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Splenic Artery; Tyrosine; Vasodilation | 2000 |
Nitrite inhalation in rats elevates tissue NOS III expression and alters tyrosine nitration and phosphorylation.
Topics: Animals; Blotting, Western; Kidney; Liver; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Phosphorylation; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
Nitric oxide indices in human septic shock.
Topics: Adolescent; Adult; Humans; Nitrates; Nitric Oxide; Nitrites; Prospective Studies; Severity of Illness Index; Shock, Septic; Sulfhydryl Compounds; Tyrosine | 2000 |
Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Edema; Cerebral Arteries; Cyclic N-Oxides; Free Radical Scavengers; Gerbillinae; Hippocampus; Lipid Peroxides; Male; Malondialdehyde; Motor Activity; Neutrophil Infiltration; Nitrates; Nitrites; Peroxidase; Poly(ADP-ribose) Polymerases; Reperfusion Injury; Spin Labels; Survival Analysis; Tyrosine | 2000 |
Nitration and hydroxylation of aromatic amino acid and guanine by the air pollutant peroxyacetyl nitrate.
Topics: Air Pollutants; Amino Acids, Cyclic; Chromatography, High Pressure Liquid; Guanine; HL-60 Cells; Humans; Hydroxylation; Mass Spectrometry; Nitrates; Nitrogen; Oxidants; Peracetic Acid; Phenylalanine; Tryptophan; Tyrosine | 2000 |
Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity.
Topics: Cells, Cultured; Endothelium, Vascular; Free Radicals; Humans; Intercellular Adhesion Molecule-1; Nitrates; Nitric Oxide; Nitrites; Potassium Dichromate; RNA, Messenger; Superoxides; Tyrosine | 2000 |
Effects of homocysteine on endothelial nitric oxide production.
Topics: Animals; Arginine; Bradykinin; Calcimycin; Cells, Cultured; Endothelium, Vascular; Folic Acid; Free Radical Scavengers; Homocysteine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Reactive Oxygen Species; Recombinant Proteins; Superoxides; Tyrosine | 2000 |
Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbits.
Topics: Animals; Brain; Enzyme Inhibitors; Guanidines; Immunoenzyme Techniques; Male; Malondialdehyde; Meningitis, Bacterial; Meningitis, Meningococcal; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peroxidase; Proteins; Rabbits; Streptococcal Infections; Streptococcus agalactiae; Tyrosine | 2000 |
Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypertension; Immunoassay; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proline; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Thiocarbamates; Tyrosine; Vasodilation | 2000 |
Application of chemically induced dynamic nuclear polarization to the nitration of N-acetyltyrosine and to some reactions of peroxynitrite.
Topics: Absorption; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrates; Nitric Acid; Nitrites; Nitrobenzenes; Nitrogen Isotopes; Tyrosine | 2000 |
Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease.
Topics: Blotting, Western; Enzyme Induction; Female; Humans; Hydrogen Peroxide; Male; Middle Aged; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrophotometry; Tyrosine | 2000 |
The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein.
Topics: Amino Acids; Animals; Immunohistochemistry; Male; Models, Biological; Nitrates; Nitric Oxide; Nitroarginine; Proteins; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Superoxide Dismutase; Tyrosine; Wounds, Nonpenetrating | 2000 |
Reactions of peroxynitrite in the mitochondrial matrix.
Topics: Animals; Ascorbic Acid; Blotting, Western; Carbon Dioxide; Glutathione; Inhibitory Concentration 50; Kinetics; Mice; Mitochondria, Liver; NAD; Nitrates; Oxidation-Reduction; Spectrometry, Fluorescence; Superoxides; Tyrosine; Ubiquinone | 2000 |
Dopamine-melanin protects against tyrosine nitration, tryptophan oxidation and Ca(2+)-ATPase inactivation induced by peroxynitrite.
Topics: Animals; Antioxidants; Calcium-Transporting ATPases; Cattle; Erythrocyte Membrane; Humans; Kinetics; Melanins; Nitrates; Oxidants; Oxidation-Reduction; Serum Albumin, Bovine; Tryptophan; Tyrosine | 2000 |
Role of nitric oxide and superoxide in acute cardiac allograft rejection in rats.
Topics: Acute Disease; Animals; Electron Spin Resonance Spectroscopy; Graft Rejection; Heart Transplantation; In Vitro Techniques; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Perfusion; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Superoxide Dismutase; Superoxides; Transplantation, Homologous; Tyrosine | 2000 |
Autocatalytic nitration of P450CAM by peroxynitrite.
Topics: Binding Sites; Blotting, Western; Camphor 5-Monooxygenase; Carbon Monoxide; Catalysis; Cytochrome P-450 Enzyme System; Heme; Hydroxylation; Intramolecular Oxidoreductases; Kinetics; Ligands; Mass Spectrometry; Models, Molecular; Nitrates; Nitrogen; Phenol; Protein Binding; Protein Conformation; Protons; Spectrophotometry; Time Factors; Tyrosine | 2000 |
Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway.
Topics: Animals; Apoptosis; Carbon Dioxide; Cells, Cultured; Cytokines; Fetus; Hypercapnia; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pulmonary Alveoli; Rats; Respiratory Mucosa; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts.
Topics: Androstadienes; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Molsidomine; Morpholines; Nitrates; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Skin; Time Factors; Tyrosine; Tyrphostins; Wortmannin | 2000 |
Protective effects of melatonin in ischemic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Gerbillinae; Immunoenzyme Techniques; Male; Malondialdehyde; Melatonin; Motor Activity; Nitrates; Nitrites; Oxidative Stress; Peroxidase; Poly(ADP-ribose) Polymerases; Reperfusion Injury; Tyrosine | 2000 |
Effects of propofol on endothelial cells subjected to a peroxynitrite donor (SIN-1).
Topics: Anesthetics, Intravenous; Cell Culture Techniques; Cell Death; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Molsidomine; Nitrates; Nitric Oxide Donors; Propofol; Tyrosine | 2000 |
Inducible nitric oxide synthase-knockout mice exhibit resistance to pleurisy and lung injury caused by carrageenan.
Topics: Animals; Carrageenan; Cells, Cultured; DNA Damage; Enzyme Activation; Exudates and Transudates; Immunohistochemistry; Lipid Peroxidation; Lung; Macrophages; Male; Malondialdehyde; Mice; Mice, Knockout; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Pleura; Pleurisy; Poly(ADP-ribose) Polymerases; Tyrosine | 2000 |
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Antibodies; Blotting, Western; Brain Diseases; Female; Humans; Immunohistochemistry; Inclusion Bodies; Lewy Bodies; Male; Middle Aged; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroglia; Nitrates; Synucleins; Tissue Distribution; Tyrosine | 2000 |
Mechanism for the peroxynitrite scavenging activity by anthocyanins.
Topics: Anthocyanins; Chromatography, High Pressure Liquid; Free Radical Scavengers; Kinetics; Nitrates; Nitrobenzoates; Oxidants; Parabens; Tyrosine | 2000 |
Nitration and inactivation of cytochrome P450BM-3 by peroxynitrite. Stopped-flow measurements prove ferryl intermediates.
Topics: Animals; Bacillus; Bacterial Proteins; Binding Sites; Blotting, Western; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dithiothreitol; Dose-Response Relationship, Drug; Erythrocytes; Glutathione; Inhibitory Concentration 50; Iron; Mass Spectrometry; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Molsidomine; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitric Oxide Donors; Nitrogen; Oxygen; Superoxide Dismutase; Temperature; Time Factors; Tyrosine; Uric Acid | 2000 |
Inflammatory properties of IgG modified by oxygen radicals and peroxynitrite.
Topics: Acute Disease; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Binding Sites, Antibody; Complement C1q; Complement C3; Female; Free Radicals; Gout; Humans; Hydrogen Peroxide; Hypochlorous Acid; Immunoglobulin G; Male; Neutrophils; Nitrates; Osteoarthritis; Oxidation-Reduction; Oxygen; Rabbits; Receptors, IgG; Serum Albumin, Bovine; Synovial Fluid; Tyrosine | 2000 |
GnRH agonist-suppressed expression of nitric oxide synthases and generation of peroxynitrite in adenomyosis.
Topics: Adult; Endometriosis; Endometrium; Epithelial Cells; Female; Follicular Phase; Gonadotropin-Releasing Hormone; Humans; Luteal Phase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Stromal Cells; Tyrosine | 2000 |
A reevaluation of the peroxynitrite scavenging activity of some dietary phenolics.
Topics: alpha 1-Antitrypsin; Bicarbonates; Caffeic Acids; Chlorogenic Acid; Coumaric Acids; Diet; Free Radical Scavengers; Gallic Acid; Kinetics; Nitrates; Oxidants; Pancreatic Elastase; Phenols; Structure-Activity Relationship; Tyrosine | 2000 |
Peroxynitrite formation in the orbit of diabetics with rhinocerebral mucormycosis.
Topics: Adolescent; Adult; Aged; Brain Diseases; Diabetes Mellitus; Eye Infections, Fungal; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Mucormycosis; Nitrates; Orbital Diseases; Paranasal Sinus Diseases; Respiratory Burst; Tyrosine | 2000 |
Enhanced peroxynitrite formation is associated with vascular aging.
Topics: Acetylcholine; Aging; Animals; Aorta; Body Weight; Calcimycin; Cellular Senescence; Endothelium, Vascular; Enzyme Induction; Hemodynamics; Male; Microscopy, Immunoelectron; Mitochondria; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxidative Stress; Rats; Rats, Inbred Strains; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation | 2000 |
LC-MS/MS detection of peroxynitrite-derived 3-nitrotyrosine in rat microvessels.
Topics: Animals; Brain; Chromatography, Liquid; Mass Spectrometry; Microcirculation; Microscopy, Phase-Contrast; Nitrates; Rats; Rats, Wistar; Sensitivity and Specificity; Tyrosine | 2000 |
A novel procedure for generating both nitric oxide and superoxide in situ from chemical sources at any chosen mole ratio. First application: tyrosine oxidation and a comparison with preformed peroxynitrite.
Topics: Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxidants; Oxidation-Reduction; Spermine; Superoxides; Tyrosine | 2000 |
Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase.
Topics: Animals; Antioxidants; Biomarkers; Bronchoalveolar Lavage Fluid; Cytokines; Female; Gene Expression Regulation, Enzymologic; Glutathione Disulfide; Humans; Influenza A virus; Influenza, Human; Lung; Male; Mice; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Pneumonia, Viral; Pulmonary Edema; RNA, Messenger; Superoxide Dismutase; Thromboxane B2; Tyrosine | 2001 |
Reactive oxygen and nitrogen metabolites modulate fibronectin-induced fibroblast migration in vitro.
Topics: Blood; Cell Line; Cell Movement; Complement Activation; Deferoxamine; Dithiothreitol; Embryo, Mammalian; Fibroblasts; Fibronectins; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrogen; Reactive Oxygen Species; Reducing Agents; Superoxides; Tyrosine; Xanthine Oxidase | 2001 |
Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arterial Occlusive Diseases; Catalysis; Cytokines; Fluorescent Antibody Technique; Ileum; Leukocyte Count; Male; Malondialdehyde; Manganese; Nitrates; Nitrites; Organometallic Compounds; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Splanchnic Circulation; Superoxide Dismutase; Superoxides; Tyrosine | 2001 |
Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase.
Topics: Animals; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotoxins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Reference Values; Superoxide Dismutase; Tyrosine | 2001 |
Adenovirus infection increases iNOS and peroxynitrite production in the lung.
Topics: Adenoviridae Infections; Animals; Blotting, Western; Bronchoalveolar Lavage Fluid; Female; Immunohistochemistry; Lung; Male; Mice; Mice, Inbred BALB C; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pulmonary Surfactants; Tyrosine | 2001 |
Impaired response to interferon-gamma in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric oxide.
Topics: Animals; Blotting, Western; Cell Line; Densitometry; DNA-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Lipopolysaccharides; Macrophage Activation; Macrophages; Methionine; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 2001 |
Is ceruloplasmin an important catalyst for S-nitrosothiol generation in hypercholesterolemia?
Topics: Apolipoproteins B; Ascorbic Acid; Catalysis; Ceruloplasmin; Cholesterol; Cholesterol Esters; Cholesterol, LDL; Humans; Hydrogen Peroxide; Hypercholesterolemia; Lipoproteins, LDL; Mercaptoethanol; Nitrates; Nitrites; Nitroso Compounds; S-Nitrosothiols; Tyrosine; Uric Acid; Vitamin E | 2001 |
No evidence of NO-induced damage in potential donor organs after brain death.
Topics: Animals; Biomarkers; Brain Death; Chromatography, High Pressure Liquid; Heart Transplantation; Hemodynamics; Lipid Peroxidation; Liver; Liver Transplantation; Male; Multiple Organ Failure; Myocardium; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Wistar; Thiobarbiturates; Tissue Donors; Tyrosine | 2001 |
Antioxidative properties of phenolic antioxidants isolated from corn steep liquor.
Topics: Acetates; Animals; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Erythrocyte Membrane; Fermentation; Lipoproteins; Magnetic Resonance Spectroscopy; Nitrates; Phenols; Rabbits; Tyrosine; Vitamin E; Zea mays | 2001 |
Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis.
Topics: Aging; Animals; Apoptosis; Blotting, Northern; Blotting, Western; Collagen; Cysteine Endopeptidases; DNA Fragmentation; Gene Expression Regulation, Enzymologic; Image Processing, Computer-Assisted; In Situ Nick-End Labeling; Male; Multienzyme Complexes; Muscle, Smooth; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penis; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Tyrosine; Ubiquitins | 2001 |
Nitrated and oxidized plasma proteins in smokers and lung cancer patients.
Topics: Aged; Aged, 80 and over; Blood Proteins; Blotting, Western; Female; Humans; Immunoblotting; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Nitrates; Oxidation-Reduction; Precipitin Tests; Smoking; Tyrosine | 2001 |
Endogenous and new synthetic antioxidants for peroxynitrite: selective inhibitory effect of 5-methoxytryptamine and lipoic acid on tyrosine nitration by peroxynitrite.
Topics: 5-Methoxytryptamine; Antioxidants; Chromatography, High Pressure Liquid; Dopamine Agents; Levodopa; Nitrates; Oxidants; Oxidation-Reduction; Proline; Pyrrolidines; Thioctic Acid; Tyrosine | 1999 |
Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure.
Topics: Animals; Creatine Kinase; Creatine Kinase, MM Form; Heart Failure; Image Processing, Computer-Assisted; Immunohistochemistry; Isoenzymes; Male; Myofibrils; Myosins; Nitrates; Oxidants; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control.
Topics: Adult; Aged; Case-Control Studies; Catalase; Cyclic GMP; Diabetes Mellitus, Type 2; Erythrocytes; Female; Glutathione Peroxidase; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Reactive Oxygen Species; Selenium; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2001 |
Peroxynitrite inhibits the activity of ornithine decarboxylase.
Topics: Animals; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Nitrates; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidants; Rats; Recombinant Proteins; Tyrosine | 2001 |
Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Ischemic Attack, Transient; Male; Middle Cerebral Artery; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Reference Values; Superoxides; Tamoxifen; Tyrosine | 2001 |
Chemical evaluation of compounds as nitric oxide or peroxynitrite donors using the reactions with serotonin.
Topics: Aerobiosis; Chromatography, High Pressure Liquid; Copper; Glutathione; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; S-Nitrosoglutathione; Serotonin; Tyrosine | 2001 |
Effect of peroxynitrite on motor function of the opossum esophagus.
Topics: Animals; Enzyme Inhibitors; Esophagitis; Esophagogastric Junction; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitrates; Opossums; Oxadiazoles; Oxidants; Oxyhemoglobins; Quinoxalines; Tyrosine | 2001 |
Cytotoxic effects of peroxynitrite, polymorphonuclear neutrophils, free-radical scavengers, inhibitors of myeloperoxidase, and inhibitors of nitric oxide synthase on bovine mammary secretory epithelial cells.
Topics: Aniline Compounds; Animals; Antioxidants; Blotting, Western; Cattle; Cell Death; Enzyme Inhibitors; Epithelial Cells; Female; Free Radical Scavengers; Histidine; L-Lactate Dehydrogenase; Lipopolysaccharides; Mammary Glands, Animal; Molsidomine; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidants; Peroxidase; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
Inhibition of peroxynitrite-induced dityrosine formation with oxidized and reduced thiols, nitric oxide donors, and purine derivatives.
Topics: Molecular Structure; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Purines; Sulfhydryl Compounds; Tyrosine; Uric Acid | 2001 |
Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species.
Topics: Eosinophil Peroxidase; Eosinophils; Free Radicals; Humans; Immunohistochemistry; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Oxidants; Oxidation-Reduction; Peroxidases; Phenylpropionates; Proteins; Reactive Oxygen Species; Status Asthmaticus; Tyrosine | 2001 |
Peroxynitrite inhibits inducible (type 2) nitric oxide synthase in murine lung epithelial cells in vitro.
Topics: Animals; Base Sequence; Cell Line; DNA Primers; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Hydrazines; Lung; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; RNA, Messenger; Tyrosine | 2001 |
Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat.
Topics: Acetylcysteine; Animals; Blotting, Western; Carrageenan; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Erythrocytes; Free Radical Scavengers; I-kappa B Proteins; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lung; Macrophages; Male; Malondialdehyde; Neutrophils; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide; P-Selectin; Peroxidase; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.
Topics: Adenocarcinoma; Animals; Azoles; Bradykinin; Capillary Permeability; Collagenases; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Precursors; Free Radical Scavengers; Gelatinases; Guinea Pigs; Isoindoles; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Nitrates; Oligopeptides; Organoselenium Compounds; Protease Inhibitors; Sarcoma 180; Skin; Tyrosine; Uric Acid | 2001 |
Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Death; Colitis; Colon; Disease Models, Animal; Epithelial Cells; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lysine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Superoxides; Trinitrobenzenesulfonic Acid; Tyrosine | 2001 |
Nitric oxide and Coxsackievirus B3 myocarditis: differential expression of inducible nitric oxide synthase in mouse heart after infection with virulent or attenuated virus.
Topics: Animals; Disease Models, Animal; Enterovirus; Guanosine Monophosphate; Heart; Immunohistochemistry; Male; Mice; Myocarditis; Myocardium; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nucleic Acid Hybridization; RNA, Viral; Tyrosine | 2001 |
Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Membrane Glycoproteins; Mercury Poisoning, Nervous System; Methylmercury Compounds; Nerve Degeneration; Neurons; Nitrates; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2001 |
In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation.
Topics: Annexin A5; Apoptosis; Cells, Cultured; Child, Preschool; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; In Situ Nick-End Labeling; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stromal Cells; Superoxide Dismutase; Superoxides; T-Lymphocytes; Thymus Gland; Tyrosine | 2001 |
Site-selective nitration of tyrosine in human serum albumin by peroxynitrite.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Molecular Structure; Nitrates; Peptides; Serum Albumin; Tyrosine | 2001 |
Long-term inhalation of high-dose nitric oxide increases intraalveolar activation of coagulation system in mice.
Topics: Administration, Inhalation; Animals; Blood Coagulation; Bronchi; Bronchoalveolar Lavage Fluid; Cell Line; Female; Immunohistochemistry; Lung; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitro Compounds; Proteins; Pulmonary Alveoli; Reverse Transcriptase Polymerase Chain Reaction; Thrombin; Thromboplastin; Tyrosine | 2001 |
Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution.
Topics: Bicarbonates; Cyclic N-Oxides; Free Radicals; Hydroxyl Radical; Lipid Bilayers; Liposomes; Mass Spectrometry; Membranes, Artificial; Molsidomine; Nitrates; Nitrosation; Oxidation-Reduction; Solutions; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spin Labels; Tyrosine; Water | 2001 |
Protein tyrosine nitration in cytokine-activated murine macrophages. Involvement of a peroxidase/nitrite pathway rather than peroxynitrite.
Topics: Animals; Cell Line; Cytokines; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Free Radical Scavengers; Hydrogen Peroxide; Immunoblotting; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitrates; Nitric Oxide; Nitrites; Nitrogen; Oxygen; Peroxidase; Recombinant Proteins; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; Zymosan | 2001 |
Investigation of tyrosine nitration in proteins by mass spectrometry.
Topics: Affinity Labels; Angiotensin II; Hydrolysis; Indicators and Reagents; Mass Spectrometry; Nitrates; Proteins; Sequence Analysis, Protein; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2001 |
Inducible nitric oxide synthase knockout mice exhibit resistance to the multiple organ failure induced by zymosan.
Topics: Animals; Enzyme Inhibitors; Exudates and Transudates; Guanidines; Lipid Peroxidation; Liver; Lung; Macrophages, Peritoneal; Male; Mice; Mice, Knockout; Multiple Organ Failure; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peritonitis; Peroxidase; Poly(ADP-ribose) Polymerases; Rhodamines; Shock; Tyrosine; Zymosan | 2001 |
Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity.
Topics: Adjuvants, Immunologic; Animals; Apoptosis; Caspases; Cell Division; Cell Line; Dermatitis, Contact; DNA Damage; DNA Fragmentation; Female; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Interleukin-8; Keratinocytes; Mice; Mice, Inbred Strains; Necrosis; Nitrates; Oxazolone; Poly(ADP-ribose) Polymerases; Skin; Tyrosine | 2001 |
Myoglobin-catalyzed tyrosine nitration: no need for peroxynitrite.
Topics: Animals; Horses; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Metmyoglobin; Myocardium; Myoglobin; Nitrates; Nitrites; Oxidation-Reduction; Tyrosine | 2001 |
Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats.
Topics: Acetylcholine; Acetylcysteine; Animals; Aorta; Drug Synergism; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Hypertension; In Vitro Techniques; Isoproterenol; Male; Malondialdehyde; Nitrates; Nitroprusside; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents; Vasomotor System | 2001 |
Epicatechin selectively prevents nitration but not oxidation reactions of peroxynitrite.
Topics: Animals; Catechin; Cell-Free System; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Fluoresceins; Glyceraldehyde-3-Phosphate Dehydrogenases; Lipoxygenase; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrates; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sulfhydryl Compounds; Tyrosine | 2001 |
Preconditioning decreases ischemia/reperfusion-induced peroxynitrite formation.
Topics: Animals; Aorta; Blood Flow Velocity; In Vitro Techniques; Ischemic Preconditioning, Myocardial; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Nitrates; Rats; Rats, Wistar; Time Factors; Tyrosine; Ventricular Function, Left | 2001 |
Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation.
Topics: Animals; Blotting, Western; Cerebellum; Disease Models, Animal; Enzyme Inhibitors; Glucose; Hypoxia-Ischemia, Brain; Immunohistochemistry; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Purkinje Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Tyrosine | 2001 |
Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice.
Topics: Animals; Female; Gene Expression Regulation, Enzymologic; Genotype; Heart Ventricles; Hemodynamics; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardial Contraction; Myocardial Infarction; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger; Survival Rate; Time Factors; Tyrosine | 2001 |
Peroxynitrite causes endothelial cell monolayer barrier dysfunction.
Topics: Actins; Animals; beta Catenin; Cell Survival; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Pulmonary Artery; Reactive Oxygen Species; Superoxide Dismutase; Swine; Trans-Activators; Tyrosine | 2001 |
-OONO: rebounding from nitric oxide.
Topics: Administration, Inhalation; Animals; Endothelium, Vascular; Epoprostenol; Hemoglobins; Humans; Hydroxyl Radical; Hypertension, Pulmonary; Nitrates; Nitric Oxide; Nitrogen Dioxide; Oxidation-Reduction; Pneumonia; Prostaglandin H2; Prostaglandins H; Signal Transduction; Superoxides; Tyrosine | 2001 |
Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy.
Topics: Administration, Inhalation; Animals; Blotting, Western; Cells, Cultured; Dioxoles; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Humans; Hypertension, Pulmonary; Lung; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pulmonary Artery; Receptor, Endothelin A; Secondary Prevention; Sheep; Superoxides; Tyrosine | 2001 |
Oxidative stress and reactive nitrogen species generation during renal ischemia.
Topics: Aldehydes; Animals; Blood Urea Nitrogen; Creatinine; Free Radicals; Glutathione; Kidney; Male; Nitrates; Oxidation-Reduction; Oxidative Stress; Proteins; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Tyrosine | 2001 |
Peroxynitrite formation from human myocardium after ischemia-reperfusion during open heart operation.
Topics: Adult; Aged; Cardiopulmonary Bypass; Creatine Kinase; Creatine Kinase, MB Form; Female; Heart Valve Prosthesis Implantation; Humans; Isoenzymes; Male; Malondialdehyde; Middle Aged; Myocardial Reperfusion Injury; Myocardium; Nitrates; Tyrosine | 2001 |
Acute hyperglycemia induces an oxidative stress in healthy subjects.
Topics: Adult; Biomarkers; Confounding Factors, Epidemiologic; Diabetic Angiopathies; Female; Glucose Clamp Technique; Hemodynamics; Humans; Hydrogen-Ion Concentration; Hyperglycemia; Male; Nitrates; Oxidative Stress; Tyrosine; Vasoconstriction | 2001 |
Peroxynitrite-induced tyrosine nitration and inhibition of protein kinase C.
Topics: Animals; Brain; Cysteine; Isoenzymes; Male; Neurodegenerative Diseases; Nitrates; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; Penicillamine; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Tissue Extracts; Tyrosine | 2001 |
Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Central Nervous System Diseases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radicals; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Interneurons; Motor Neurons; Nerve Degeneration; Neurons; Neurotoxins; Nitrates; Nitric Oxide Donors; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spinal Cord; Tyrosine | 2001 |
Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain Chemistry; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Fever; Homovanillic Acid; Male; Methamphetamine; Nitrates; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation.
Topics: Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Female; Immunosuppressive Agents; Interferon-gamma; Macrophages; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Pneumonia; Survival Rate; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Nitrates; omega-N-Methylarginine; Precipitin Tests; Proteins; Rats; Rats, Wistar; Tyrosine | 2001 |
Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants.
Topics: Acetates; Acetylcholine; Animals; Antioxidants; Biological Transport; Carbon Radioisotopes; Choline; Choline O-Acetyltransferase; Drug Interactions; Molsidomine; Nitrates; Oxidants; Reducing Agents; Torpedo; Tyrosine; Uric Acid | 2001 |
Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs.
Topics: Animals; Blood Gas Analysis; Blotting, Western; Disease Models, Animal; Hemodynamics; Lipopolysaccharides; Liver; Lung; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Sepsis; Swine; Tyrosine | 2001 |
Acidic fibroblast growth factor signaling inhibits peroxynitrite-induced death of osteoblasts and osteoblast precursors.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Fibroblast Growth Factor 1; Mice; Nitrates; Osteoblasts; Osteocalcin; Osteopontin; Peroxynitrous Acid; Rats; Sialoglycoproteins; Signal Transduction; Stem Cells; Tyrosine | 2001 |
Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Gene Deletion; Immunoenzyme Techniques; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Tyrosine | 2001 |
Inactivation of glutathione S-transferases by nitric oxide-derived oxidants: exploring a role for tyrosine nitration.
Topics: Animals; Chromatography, Affinity; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutathione Transferase; Hydrogen Peroxide; Liver; Male; Mice; Nitrates; Nitric Oxide; Oxidants; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reducing Agents; S-Nitrosoglutathione; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2001 |
Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite.
Topics: Animals; Female; Free Radical Scavengers; Hydrogen Peroxide; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide; Nitrites; Peroxidase; Peroxynitrous Acid; Propionibacterium acnes; Proteins; Superoxides; Thioglycolates; Time Factors; Tyrosine | 2001 |
Lack of influence of dietary nitrate/nitrite on plasma nitrotyrosine levels measured using a competitive inhibition of binding ELISA assay.
Topics: Adult; Binding, Competitive; Blood Proteins; Diet; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nitrates; Nitrites; Sensitivity and Specificity; Tyrosine | 2001 |
The nitrite/collagen reaction: non-enzymatic nitration as a model system for age-related damage.
Topics: Aging; Collagen Type I; Humans; Nitrates; Nitrogen; Tyrosine | 2001 |
(-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments.
Topics: Antioxidants; Catechin; Dimerization; In Vitro Techniques; Liposomes; Nitrates; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2001 |
Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes.
Topics: Animals; Apoptosis; Benzamides; Caspases; Cells, Cultured; DNA Damage; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Mitochondria; Nitrates; Nitrites; Nitrogen Oxides; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protective Agents; Thymus Gland; Tyrosine | 2001 |
High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cel
Topics: Aorta; Apoptosis; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; DNA Fragmentation; Endothelium, Vascular; Glucose; Humans; Nitrates; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Superoxides; Tyrosine | 2002 |
Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency.
Topics: alpha-Tocopherol; Animals; Antioxidants; Arginine; Creatinine; Endothelium, Vascular; Kidney Failure, Chronic; Male; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine | 2002 |
Catalase catalyzes nitrotyrosine formation from sodium azide and hydrogen peroxide.
Topics: Animals; Catalase; Catalysis; Cattle; Hydrogen Peroxide; Hydrogen-Ion Concentration; Luminescent Measurements; Nitrates; Nitrites; Serum Albumin, Bovine; Sodium Azide; Time Factors; Tyrosine | 2001 |
Protein denitration/modification by Escherichia coli nitrate reductase and mammalian cytochrome P-450 reductase.
Topics: Animals; Escherichia coli; Histones; Models, Chemical; NADP; NADPH-Ferrihemoprotein Reductase; Nitrate Reductase; Nitrate Reductases; Nitrates; Peroxynitrous Acid; Tyrosine | 2002 |
The role of protein nitration in the inhibition of platelet activation by peroxynitrite.
Topics: Blood Platelets; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Nitrates; Nitric Oxide; Peroxynitrous Acid; Phosphorylation; Platelet Activation; Platelet Aggregation; Proteins; Signal Transduction; Thrombin; Time Factors; Tyrosine | 2002 |
Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation.
Topics: Genistein; Humans; Isoflavones; Lipoproteins, LDL; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2002 |
Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver.
Topics: Adenocarcinoma; Aged; Apoptosis; Cell Division; Colorectal Neoplasms; Female; Humans; Immunoenzyme Techniques; Liver Neoplasms; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxidative Stress; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Tyrosine | 2002 |
Protein tyrosine nitration in the ventilatory muscles: role of nitric oxide synthases.
Topics: Animals; Extremities; Male; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proteins; Rats; Rats, Sprague-Dawley; Reference Values; Respiratory Muscles; Sepsis; Tyrosine | 2002 |
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.
Topics: Aged; alpha-Synuclein; Brain; Cell Nucleus; Female; Humans; Inclusion Bodies; Lewy Bodies; Lewy Body Disease; Male; Middle Aged; Nerve Tissue Proteins; Neurites; Neuroglia; Neurons; Nitrates; Oxidative Stress; Striatonigral Degeneration; Synucleins; Tyrosine | 2002 |
Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Apoptosis; Disease Models, Animal; DNA; DNA-Binding Proteins; Endotoxins; Enzyme Activation; Hypertension; I-kappa B Proteins; Lung; Male; Neutrophils; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Sesquiterpenes; Shock, Septic; Tyrosine | 2002 |
Cardiac response to nitric oxide synthase inhibition using aminoguanidine in a rat model of endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Endotoxins; Enzyme Inhibitors; Guanidines; Heart; In Vitro Techniques; Male; Myocytes, Cardiac; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Perfusion; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver.
Topics: Amidines; Animals; Aspartate Aminotransferases; Enzyme Inhibitors; Female; Heterocyclic Compounds, 2-Ring; Hot Temperature; Ischemia; L-Lactate Dehydrogenase; Liver; Liver Circulation; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Reperfusion Injury; Survival Analysis; Swine; Thrombosis; Tissue Distribution; Tyrosine | 2002 |
Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress.
Topics: alpha-Synuclein; Dimerization; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; In Vitro Techniques; Microscopy, Confocal; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Synucleins; Tyrosine | 2002 |
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Aging; Animals; Arginine; Arterioles; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Immunohistochemistry; In Vitro Techniques; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tyrosine; Vasodilation; Xanthine Oxidase | 2002 |
Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity.
Topics: Amino Acid Sequence; Animals; Cell Line; Humans; Mice; Models, Molecular; Molecular Sequence Data; Muscle, Skeletal; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Conformation; Rats; Recombinant Proteins; Sepsis; Spodoptera; Transfection; Tyrosine | 2002 |
Protein nitration is predominantly mediated by a peroxynitrite-dependent pathway in cultured human leucocytes.
Topics: Aniline Compounds; Cells, Cultured; Extracellular Space; Humans; Leukocytes; Metalloporphyrins; Nitrates; Peroxidase; Peroxynitrous Acid; Proteins; Spermine; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Reactive nitrogen intermediates in giant cell arteritis: selective nitration of neocapillaries.
Topics: Animals; Capillaries; Chimera; Endothelium, Vascular; Giant Cell Arteritis; Humans; Macrophages; Mice; Mice, Inbred NOD; Mice, SCID; Neovascularization, Physiologic; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reactive Nitrogen Species; Stress, Physiological; Tunica Media; Tyrosine | 2002 |
Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure.
Topics: ADAM Proteins; ADAM12 Protein; Adult; Cardiac Output, Low; Cell Count; Connexin 43; Endocardium; Endopeptidases; Endothelium, Vascular; Humans; Integrin beta1; Membrane Proteins; Metalloendopeptidases; Middle Aged; Myocardium; Nitrates; Nitrites; Oxidative Stress; Protease Inhibitors; Reactive Oxygen Species; Tyrosine | 2002 |
Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Immunohistochemistry; Lipid Peroxides; Luminescent Measurements; Lung; Macrophages, Alveolar; Male; Nitrates; Nitric Oxide; Nitrites; Pulmonary Alveoli; Rats; Rats, Inbred F344; Reactive Oxygen Species; Silicon Dioxide; Superoxide Dismutase; Time Factors; Tyrosine; Zymosan | 2002 |
Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade.
Topics: Aging; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arterioles; Hypertension, Renal; Immunoenzyme Techniques; Kidney Failure, Chronic; Kidney Glomerulus; Losartan; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Tyrosine | 2002 |
The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans.
Topics: Administration, Oral; Adolescent; Adult; Collagen; Cyclic GMP; Diet, Vegetarian; Female; Gastric Juice; Humans; Kinetics; Male; Nitrates; Platelet Aggregation; Platelet Function Tests; S-Nitrosothiols; Tyrosine | 2002 |
Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63.
Topics: Amino Acid Sequence; Animals; Aquaporin 2; Aquaporin 6; Aquaporins; Biological Transport; Cell Line; Cell Membrane; Electrophysiology; Green Fluorescent Proteins; Humans; Hydrogen-Ion Concentration; Ions; Isoleucine; Luminescent Proteins; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nitrates; Patch-Clamp Techniques; Protein Binding; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Software; Threonine; Transfection; Tyrosine; Xenopus laevis | 2002 |
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats.
Topics: Animals; Endotoxemia; Heart Diseases; Hydrogen Peroxide; Lipopolysaccharides; Male; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxygen Consumption; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sepsis; Superoxides; Tyrosine; Xanthine Oxidase | 2002 |
Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes.
Topics: Adolescent; Adult; Autonomic Nervous System; Child; Diabetes Mellitus, Type 1; Dinoprost; F2-Isoprostanes; Female; Heart Conduction System; Humans; Male; Motor Neurons; Neural Conduction; Nitrates; Nitrites; Peripheral Nerves; Peroxynitrous Acid; Reference Values; Sweating; Time Factors; Tyrosine; Uric Acid | 2002 |
Nitric oxide and protein nitration in the cystic fibrosis airway.
Topics: Adult; Aged; Analysis of Variance; Cystic Fibrosis; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Reference Values; Respiratory Mechanics; Respiratory System; Tyrosine | 2002 |
Role of reactive nitrogen intermediates and protein nitration during immune response against a rat histiocytoma.
Topics: Animals; Ascites; Ascitic Fluid; Blotting, Western; Cells, Cultured; Coculture Techniques; Histiocytoma, Benign Fibrous; Macrophage Activation; Macrophages; Neoplasm Transplantation; Neoplasms, Experimental; Nitrates; Nitrites; Proteins; Rats; Rats, Wistar; Skin Neoplasms; Tyrosine | 2002 |
Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats.
Topics: Administration, Inhalation; Alkylating Agents; Animals; Antibody Specificity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cyclophosphamide; Immunohistochemistry; Leukocyte Count; Lipopolysaccharides; Lung; Male; Neutropenia; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
iNOS depletion completely diminishes reactive nitrogen-species formation after an allergic response.
Topics: Allergens; Animals; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophils; Immunization; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Ovalbumin; Reactive Nitrogen Species; Respiratory Hypersensitivity; Tyrosine | 2002 |
Peroxynitrite scavenging activity of sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) isolated from Brassica juncea.
Topics: Brassica; Coumaric Acids; Free Radical Scavengers; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
Simultaneous determination of 3-nitrotyrosine and tyrosine in plasma proteins of rats and assessment of artifactual tyrosine nitration.
Topics: Animals; Artifacts; Blood Proteins; Chromatography, High Pressure Liquid; Mass Spectrometry; Nitrates; Rats; Tyrosine | 2002 |
Transport of nitrated albumin across continuous vascular endothelium.
Topics: Albumins; Animals; Binding Sites; Biological Transport, Active; Cross-Linking Reagents; Endothelium, Vascular; Gold Colloid; Lung; Mice; Mice, Inbred BALB C; Microscopy, Electron; Myocardium; Nitrates; Perfusion; Tyrosine | 2002 |
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.
Topics: Adrenergic alpha-Antagonists; alpha-Synuclein; Animals; Body Weight; Brain; Cerebellum; Disease Models, Animal; Female; Inclusion Bodies; Macromolecular Substances; Male; Mice; Mice, Transgenic; Motor Activity; Multiple System Atrophy; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nitrates; Oligodendroglia; Phosphorylation; Prazosin; Receptors, Adrenergic, alpha-1; Spinal Cord; Survival Rate; Synucleins; Tyrosine; Ubiquitin | 2002 |
Comparison of nitration and oxidation of tyrosine in advanced human carotid plaque proteins.
Topics: Carotid Artery Diseases; Gas Chromatography-Mass Spectrometry; Humans; Nitrates; Oxidation-Reduction; Proteins; Sensitivity and Specificity; Tyrosine | 2003 |
Myoglobin scavenges peroxynitrite without being significantly nitrated.
Topics: Animals; Apoproteins; Free Radical Scavengers; Globins; Immunohistochemistry; Metmyoglobin; Myoglobin; Nitrates; Oxyhemoglobins; Peroxynitrous Acid; Tryptophan; Tyrosine | 2002 |
Nitric oxide and peroxynitrite promote complete disruption of the [4Fe-4S] cluster of recombinant human iron regulatory protein 1.
Topics: Aconitate Hydratase; Blotting, Western; Conserved Sequence; Electrophoretic Mobility Shift Assay; Ferrozine; Humans; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Mercaptoethanol; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Tyrosine | 2003 |
Lack of tyrosine nitration by hypochlorous acid in the presence of physiological concentrations of nitrite. Implications for the role of nitryl chloride in tyrosine nitration in vivo.
Topics: Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Hypochlorous Acid; Immunohistochemistry; Microscopy, Confocal; Nitrates; Nitrites; Tumor Cells, Cultured; Tyrosine | 2003 |
Quantitation and localization of tyrosine nitration in proteins.
Topics: Chromatography, High Pressure Liquid; Mass Spectrometry; Nitrates; Peptide Mapping; Proteins; Tyrosine | 2002 |
Inhibition of human surfactant protein A function by oxidation intermediates of nitrite.
Topics: Bronchoalveolar Lavage Fluid; Humans; Hydrogen Peroxide; Hypochlorous Acid; Mannose; Nitrates; Nitrites; Oxidation-Reduction; Protein Binding; Pulmonary Surfactant-Associated Protein A; Tyrosine | 2002 |
Activation of microsomal glutathione s-transferase by peroxynitrite.
Topics: Animals; Cysteine; Enzyme Activation; Glutathione Transferase; Hydrogen Peroxide; Imidazoles; Male; Microsomes, Liver; Nitrates; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tetranitromethane; Tyrosine | 2003 |
Asbestos inhalation induces tyrosine nitration associated with extracellular signal-regulated kinase 1/2 activation in the rat lung.
Topics: Animals; Asbestos, Crocidolite; Asbestos, Serpentine; Enzyme Activation; Immunohistochemistry; Inhalation Exposure; Lung; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrates; Phosphorylation; Precipitin Tests; Rats; Rats, Inbred F344; Tyrosine | 2003 |
Prevention of impairment of cerebral blood flow autoregulation during acute stage of subarachnoid hemorrhage by gene transfer of Cu/Zn SOD-1 to cerebral vessels.
Topics: Adenoviridae; Animals; Arteries; Blood Vessels; Cerebrovascular Circulation; Gene Expression; Gene Transfer Techniques; Genetic Vectors; Humans; Male; NADPH Oxidases; Nitrates; Nitrites; Pia Mater; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Transgenes; Tyrosine; Vasomotor System | 2003 |
Peroxynitrite-induced inhibition and nitration of cardiac myofibrillar creatine kinase.
Topics: Blotting, Western; Creatine Kinase; Cysteine; Dose-Response Relationship, Drug; Kinetics; Myocardium; Myofibrils; Nitrates; Peroxynitrous Acid; Reactive Nitrogen Species; Tyrosine | 2002 |
Benzodiazepine-induced protein tyrosine nitration in rat astrocytes.
Topics: Animals; Astrocytes; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Diazepam; Diazepam Binding Inhibitor; Isoquinolines; Nitrates; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2003 |
The cytotoxic effect of volatile organic compounds of the gas phase of cigarette smoke on lung epithelial cells.
Topics: Animals; Blotting, Western; Cell Death; Cell Division; Cell Line; Chromatography, Gas; Epithelial Cells; Gases; Humans; Lung; Mice; Nicotiana; Nitrates; Organic Chemicals; Proteins; Tobacco Smoke Pollution; Tyrosine | 2003 |
Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase.
Topics: Amino Acid Sequence; Animals; Aorta; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Intramolecular Oxidoreductases; Microsomes; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitrates; Oxidation-Reduction; Peptide Fragments; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Thermolysin; Trypsin; Tyrosine | 2003 |
Effect of NOS2 gene deficiency on the development of autoantibody mediated arthritis and subsequent articular cartilage degeneration.
Topics: Animals; Antibodies, Monoclonal; Arthritis, Experimental; Autoantibodies; Cartilage, Articular; Chondrocytes; Collagen Type II; Disease Models, Animal; Female; In Situ Nick-End Labeling; Interleukin-1; Lipopolysaccharides; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Tyrosine | 2003 |
Methylene blue photosensitized oxidation of hypotaurine in the presence of azide generates reactive nitrogen species: formation of nitrotyrosine.
Topics: Antioxidants; Azides; Hydrogen-Ion Concentration; Methylene Blue; Nitrates; Nitrites; Oxidation-Reduction; Oxygen; Photochemistry; Reactive Nitrogen Species; Sulfur; Taurine; Tyrosine | 2003 |
Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats.
Topics: Administration, Topical; Animals; Aqueous Humor; Chromonar; Ciliary Body; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Intercellular Adhesion Molecule-1; Iris; Lipopolysaccharides; Male; Nitrates; Nitrites; Ophthalmic Solutions; P-Selectin; Platelet Aggregation Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Lew; Salmonella; Tumor Necrosis Factor-alpha; Tyrosine; Uveitis, Anterior | 2003 |
Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetic Retinopathy; Glutathione; Hyperglycemia; Insulin; Lipid Peroxides; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Retina; Tyrosine | 2003 |
The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans.
Topics: Adult; Blood Platelets; Blood Proteins; Chromatography, High Pressure Liquid; Diet; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nitrates; Nitrites; Platelet Aggregation; Saliva; Tyrosine | 2003 |
3-Nitrotyrosine in atherosclerotic blood vessels.
Topics: Arteriosclerosis; Blood Vessels; Case-Control Studies; Humans; Molecular Diagnostic Techniques; Nitrates; Nitrites; Spectrophotometry; Thoracic Arteries; Tyrosine; Up-Regulation | 2003 |
Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714.
Topics: Amidines; Animals; Apoptosis; Aspartate Aminotransferases; DNA; Enzyme Inhibitors; Female; Hepatocytes; Heterocyclic Compounds, 2-Ring; Hot Temperature; In Situ Nick-End Labeling; Ischemia; L-Lactate Dehydrogenase; Liver; Liver Circulation; Microscopy, Confocal; Microscopy, Electron; Necrosis; Nitrates; Nitric Oxide Synthase; Nitrites; Reperfusion Injury; Swine; Time Factors; Tyrosine | 2003 |
Suboptimal inhibition of platelet aggregation following tirofiban bolus in patients undergoing percutaneous coronary intervention for unstable angina pectoris.
Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Cohort Studies; Female; Fibrinolytic Agents; Heparin; Humans; Infusions, Intravenous; Male; Middle Aged; Multivariate Analysis; Nitrates; Observer Variation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Tirofiban; Treatment Outcome; Tyrosine | 2003 |
Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice.
Topics: Animals; Argininosuccinate Synthase; Arthritis; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Penetrance; Peroxynitrous Acid; Phenotype; RNA, Messenger; Synovial Membrane; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Oxidative stress and insulin requirements in patients with recent-onset type 1 diabetes.
Topics: Adolescent; Adult; Child; Diabetes Mellitus, Type 1; Dinoprost; F2-Isoprostanes; Female; Glycated Hemoglobin; Humans; Insulin; Islets of Langerhans; Longitudinal Studies; Male; Nitrates; Nitrites; Oxidative Stress; Tyrosine | 2003 |
Selective nitration of Tyr99 in calmodulin as a marker of cellular conditions of oxidative stress.
Topics: Amino Acid Sequence; Animals; Biomarkers; Calmodulin; Chickens; Molecular Sequence Data; Nitrates; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2003 |
Modifications of tyrosine and catecholamines by peroxynitrite, nitrite and nitrate.
Topics: Catecholamines; Nitrates; Nitrites; Peroxynitrous Acid; Tyrosine | 2003 |
The nature of heme/iron-induced protein tyrosine nitration.
Topics: Animals; Brain; Heme; Hemeproteins; Hydrogen Peroxide; Kidney; Kinetics; Liver; Male; Mice; Muscle, Skeletal; Myocardium; Nitrates; Organ Specificity; Peroxidase; Sodium Nitrite; Tyrosine | 2003 |
Postnatal changes in the nitric oxide system of the rat cerebral cortex after hypoxia during delivery.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cell Differentiation; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Female; Free Radicals; Humans; Hypoxia, Brain; Immunohistochemistry; Infant, Newborn; Neuronal Plasticity; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Rats; Rats, Wistar; Tyrosine; Up-Regulation | 2003 |
Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.
Topics: Animals; Blood-Retinal Barrier; Body Weight; Diabetes Mellitus, Experimental; Endothelial Growth Factors; Enzyme Inhibitors; Gene Expression; Intercellular Signaling Peptides and Proteins; Lipid Peroxidation; Lymphokines; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Retina; RNA, Messenger; Tyrosine; Uric Acid; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage?
Topics: 3,4-Dihydroxyphenylacetic Acid; Cell Line; Dihydroxyphenylalanine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Gene Expression; Glutathione Transferase; Green Fluorescent Proteins; Humans; Hydrogen-Ion Concentration; Luminescent Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nitrates; Nitrogen Dioxide; Peroxynitrous Acid; Recombinant Fusion Proteins; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Proteomic identification of nitrated proteins in Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; Brain Chemistry; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Phosphopyruvate Hydratase; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triose-Phosphate Isomerase; Tyrosine | 2003 |
Myeloperoxidase has directly-opposed effects on nitration reaction--study on myeloperoxidase-deficient patient and myeloperoxidase-knockout mice.
Topics: Adult; Animals; Enzyme-Linked Immunosorbent Assay; Humans; Hydrogen Peroxide; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitrites; Nitrogen Dioxide; Nitrosation; Oxidation-Reduction; Peroxidase; Reactive Nitrogen Species; Time Factors; Tyrosine | 2003 |
Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine.
Topics: Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intravenous; Lipopolysaccharides; Male; Models, Chemical; Nitrates; Nitrophenols; Nitrosation; Phenylacetates; Rats; Rats, Sprague-Dawley; Reference Standards; Tyrosine | 2003 |
Role of nitric oxide and peroxynitrite anion in lung injury induced by intestinal ischemia-reperfusion in rats.
Topics: Animals; Anions; Lung; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tyrosine | 2003 |
Effects of peroxynitrite on isolated cardiac trabeculae: selective impact on myofibrillar energetic controllers.
Topics: Adenosine Triphosphatases; Animals; Creatine Kinase; Energy Metabolism; Heart; Male; Myocardial Contraction; Myocardium; Nitrates; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2003 |
Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease.
Topics: Adult; Blotting, Western; Chromatography, High Pressure Liquid; Copper; Humans; Iron; Male; Malondialdehyde; Monocytes; Nitrates; Nitric Oxide Synthase; Nitrosation; Oxidation-Reduction; Oxidative Stress; Retinal Vasculitis; Retinal Vessels; Spectrophotometry, Atomic; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tyrosine; Zinc | 2003 |
Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.
Topics: alpha-Synuclein; Cell Line; Cross-Linking Reagents; Drug Stability; Humans; In Vitro Techniques; Inclusion Bodies; Microscopy, Electron; Models, Biological; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Nitrates; Oxidation-Reduction; Oxidative Stress; Protein Processing, Post-Translational; Protein Structure, Quaternary; Recombinant Proteins; Synucleins; Tyrosine | 2003 |
Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals.
Topics: Blotting, Western; Cyclic N-Oxides; Dimerization; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Globins; Humans; Hydrogen Peroxide; Immunohistochemistry; Iron; Isomerism; Methemoglobin; Nitrates; Nitrites; Oxygen; Oxyhemoglobins; Peroxynitrous Acid; Spectrophotometry; Spin Labels; Superoxides; Tyrosine | 2003 |
Protein nitration in rat lungs during hyperoxia exposure: a possible role of myeloperoxidase.
Topics: Amino Acid Sequence; Animals; Bronchoalveolar Lavage Fluid; Cell Line; Edema; Hemorrhage; Hyperoxia; Lung; Macrophages, Alveolar; Neutrophils; Nitrates; Nitrites; Peptide Fragments; Peroxidase; Proteins; Pulmonary Surfactant-Associated Protein A; Rats; Respiratory Mucosa; Time Factors; Tyrosine | 2003 |
Effects of a PPARgamma agonist, GI262570, on renal filtration fraction and nitric oxide level in conscious rats.
Topics: Animals; Glomerular Filtration Rate; Hypoglycemic Agents; Male; Nitrates; Nitric Oxide; Nitrites; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Renal Plasma Flow, Effective; Transcription Factors; Tyrosine | 2003 |
[On the degradation of tyrosine with diluted nitric acid. II].
Topics: Humans; Nitrates; Nitric Acid; Tyrosine | 1961 |
[ON THE ANTIPEPTIC ACTIVITY OF DRUGS].
Topics: Antacids; Bismuth; Carbonates; Carrageenan; Gastric Juice; Hydroxides; Nitrates; Pepsin A; Peptic Ulcer; Pharmacology; Polysaccharides; Pylorus; Rats; Research; Sulfates; Tyrosine | 1964 |
Nitric oxide system and protein nitration are modified by an acute hypobaric hypoxia in the adult rat hippocampus.
Topics: Animals; Blotting, Western; Cell Count; Disease Models, Animal; Endothelium, Vascular; Glial Fibrillary Acidic Protein; Hippocampus; Hypoxia; Immunohistochemistry; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Tyrosine | 2003 |
Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.
Topics: Animals; Cerebrovascular Circulation; Hyperbaric Oxygenation; Hyperoxia; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Tyrosine; Vasoconstriction | 2003 |
Amelioration of cisplatin toxicity by a fermented grain food product.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antioxidants; Blood Urea Nitrogen; Cisplatin; Creatinine; Deoxyguanosine; Diet; Edible Grain; Fermentation; Intestines; Kidney; Lipid Peroxidation; Male; Nitrates; Nitrites; Rats; Rats, Inbred F344; Tyrosine; Weight Loss | 2002 |
A new pitfall in detecting biological end products of nitric oxide-nitration, nitros(yl)ation and nitrite/nitrate artefacts during freezing.
Topics: Animals; Aorta; Buffers; Cryopreservation; Cysteine; Freezing; Humans; Hydrogen-Ion Concentration; Nitrates; Nitric Oxide; Nitrites; Nitrophenols; Nitroso Compounds; Phosphates; Potassium Compounds; Rats; S-Nitrosothiols; Serum Albumin, Bovine; Tyrosine | 2003 |
Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation.
Topics: Acute Disease; Animals; Anthocyanins; Carrageenan; Dinoprostone; Exudates and Transudates; Fruit; Glucosides; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Lung; Male; Malondialdehyde; Neutrophils; Nitrates; Nitrites; Peroxidase; Plant Extracts; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2003 |
Peroxynitrite modulates acidic fibroblast growth factor (FGF-1) activity.
Topics: 3T3 Cells; Amino Acids; Animals; Cell Count; Cell Division; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Humans; Mice; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2003 |
Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia.
Topics: Animals; Antioxidants; Blood Vessels; Carotid Arteries; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Hypercholesterolemia; In Vitro Techniques; Lipids; Male; Nitrates; Nitric Oxide; Nitrites; Rabbits; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transcription Factors; Tyrosine; Vasodilation | 2003 |
Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study.
Topics: Arginine; Electron Transport; Escherichia coli Proteins; Heme; Histidine; Hydroxyquinolines; Mutagenesis, Site-Directed; Naphthols; Nitrate Reductase; Nitrate Reductases; Nitrates; Oxidation-Reduction; Polyenes; Spectrometry, Fluorescence; Terpenes; Tyrosine; Vitamin K | 2003 |
Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration.
Topics: Animals; Catalysis; Cattle; Cytochromes c; Horses; Humans; Hydrogen Peroxide; Jurkat Cells; Mitochondria, Liver; Myocardium; Nitrates; Nitrites; Peroxidase; Phenylacetates; Rats; Recombinant Proteins; Serum Albumin, Bovine; Superoxide Dismutase; Tyrosine | 2004 |
Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Cytokines; Dinoprostone; Edema; Exudates and Transudates; Immunohistochemistry; Isoenzymes; Lipid Peroxidation; Lung; Male; Neutrophil Infiltration; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Pleurisy; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazolidinediones; Transcription Factors; Tyrosine | 2004 |
Peroxynitrite delivery methods for toxicity studies.
Topics: Animals; Cells, Cultured; Dimerization; Drug Delivery Systems; Humans; Hypoxanthine; Models, Chemical; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Toxicity Tests; Tyrosine; Uric Acid; Xanthine Oxidase | 2004 |
Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation.
Topics: Animals; Carrageenan; Disease Models, Animal; Enzyme Inhibitors; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-1beta; Lung; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peptide Fragments; Peroxidase; Pleuropneumonia; Pneumonia; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Sulfides; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cell Death; Humans; Immunohistochemistry; Middle Aged; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pyramidal Cells; Temporal Lobe; Tyrosine | 2004 |
Mechanistic insight into the peroxidase catalyzed nitration of tyrosine derivatives by nitrite and hydrogen peroxide.
Topics: Animals; Cattle; Hydrogen Peroxide; Lactoperoxidase; Molecular Structure; Nitrates; Nitrites; Nitrophenols; Oxidants; Oxidation-Reduction; Reactive Nitrogen Species; Tyrosine | 2004 |
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration.
Topics: Cell Line; Cell Nucleus; Cytokines; DNA; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Genetic Techniques; Histone Deacetylase 2; Histone Deacetylases; Histones; Humans; Hydrogen Peroxide; Interleukin-1; Interleukin-8; NF-kappa B; Nitrates; Oxidative Stress; Peroxynitrous Acid; Precipitin Tests; Promoter Regions, Genetic; Repressor Proteins; Time Factors; Tyrosine | 2004 |
Nitric oxide, oxidants, and protein tyrosine nitration.
Topics: Animals; Erythrocytes; Hemoglobins; Humans; Mitochondria; Nitrates; Nitric Oxide; Oxidants; Peroxynitrous Acid; Superoxides; Tyrosine | 2004 |
Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria.
Topics: Animals; Autoradiography; Blotting, Western; Cell Hypoxia; Electrophoresis, Gel, Two-Dimensional; Mitochondria, Liver; Nitrates; Oxygen; Proteins; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2004 |
Hypoosmotic swelling increases protein tyrosine nitration in cultured rat astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Edema; Calcium Signaling; Calmodulin; Cell Size; Cells, Cultured; Chelating Agents; Excitatory Amino Acid Antagonists; Hepatic Encephalopathy; Hyperammonemia; Hypotonic Solutions; Nerve Tissue Proteins; Nitrates; Nitric Oxide; Osmolar Concentration; Oxidative Stress; Peroxynitrous Acid; Proteins; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2004 |
Protective effects of green tea catechins on cerebral ischemic damage.
Topics: Animals; Brain Ischemia; Catechin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Granulocyte Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Infarction, Middle Cerebral Artery; Interleukin-3; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Plant Extracts; Rats; Rats, Wistar; Recombinant Fusion Proteins; Recombinant Proteins; Tea; Tyrosine | 2004 |
Mechanistic studies of the isomerization of peroxynitrite to nitrate catalyzed by distal histidine metmyoglobin mutants.
Topics: Animals; Catalysis; Chromatography, High Pressure Liquid; Globins; Heme; Histidine; Hydrogen-Ion Concentration; Isomerism; Kinetics; Metmyoglobin; Mutation; Nitrates; Nitrogen; Peroxynitrous Acid; Tyrosine; Whales | 2004 |
Upregulation of endothelial nitric oxide synthase maintains nitric oxide production in the cerebellum of thioacetamide cirrhotic rats.
Topics: Animals; Blotting, Western; Cerebellum; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Liver Cirrhosis, Experimental; Male; NADPH Dehydrogenase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar; Thioacetamide; Tyrosine; Up-Regulation | 2004 |
The effects of antioxidants on peroxynitrite-induced changes in platelet proteins.
Topics: Antioxidants; Blood Platelets; Blood Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Nitrates; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Resveratrol; Stilbenes; Tyrosine | 2004 |
Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.
Topics: 3T3-L1 Cells; Animals; Binding Sites; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Molsidomine; Nitrates; Peroxynitrous Acid; Phosphoproteins; Protein Binding; Rats; Tyrosine | 2004 |
Oxygen tension and inhaled nitric oxide modulate pulmonary levels of S-nitrosocysteine and 3-nitrotyrosine in rats.
Topics: Administration, Inhalation; Animals; Cysteine; Humans; Infant; Isoenzymes; Lung; Male; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxygen; Rats; S-Nitrosothiols; Tyrosine | 2004 |
Peroxynitrite, a product between nitric oxide and superoxide anion, plays a cytotoxic role in the development of post-bypass systemic inflammatory response.
Topics: Animals; Cardiopulmonary Bypass; Free Radical Scavengers; Inflammation; Interleukin-6; Interleukin-8; Male; Nitrates; Nitric Oxide; Nitrites; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors; Tyrosine | 2004 |
Evaluation of nitrotyrosine-containing proteins in blood platelets.
Topics: Animals; Blood Platelets; Blotting, Western; Cattle; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Nitrates; Serum Albumin, Bovine; Tyrosine | 2004 |
The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice.
Topics: Animals; Ethanol; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 2004 |
Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.
Topics: alpha-Synuclein; Animals; Calpain; Humans; Insulin; Lipid Metabolism; Mice; Molecular Chaperones; Nerve Tissue Proteins; Nitrates; Oxygen; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Quaternary; Synucleins; Tyrosine | 2004 |
Scavenging of reactive nitrogen species by oxygenated hemoglobin: globin radicals and nitrotyrosines distinguish nitrite from nitric oxide reaction.
Topics: Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Hemoglobins; Humans; Methemoglobin; Models, Chemical; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Oxidative Stress; Oxyhemoglobins; Reactive Nitrogen Species; Spectrometry, Mass, Electrospray Ionization; Spin Trapping; Tyrosine | 2004 |
The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry.
Topics: Amino Acid Sequence; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Humans; Male; Mass Spectrometry; Middle Aged; Molecular Sequence Data; Nitrates; Pituitary Gland; Proteome; Sequence Analysis, Protein; Tyrosine | 2004 |
Trouble with the analysis of nitrite, nitrate, S-nitrosothiols and 3-nitrotyrosine: freezing-induced artifacts?
Topics: Artifacts; Freezing; Gas Chromatography-Mass Spectrometry; Nitrates; Nitric Oxide; Nitrites; S-Nitrosothiols; Tyrosine | 2004 |
Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport.
Topics: Amino Acid Sequence; Animals; Antioxidants; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Chlorine; Cholesterol; Cricetinae; Electron Spin Resonance Spectroscopy; Humans; Hydrogen Peroxide; Hydrophobic and Hydrophilic Interactions; Nitrates; Nitrogen; Oxidation-Reduction; Peptides; Peroxidase; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Isoprenylhydroquinone glucoside: a new non-antioxidant inhibitor of peroxynitrite-mediated tyrosine nitration.
Topics: Asteraceae; Cytochromes c; Glucosides; Hydroquinones; Molecular Structure; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Rhodamines; Tyrosine | 2005 |
Flavonoids and tyrosine nitration: structure-activity relationship correlation with enthalpy of formation.
Topics: Flavonoids; Models, Chemical; Models, Molecular; Nitrates; Nitrogen; Structure-Activity Relationship; Thermodynamics; Tyrosine | 2005 |
Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment.
Topics: Aged; Alzheimer Disease; Biomarkers; Cerebrospinal Fluid Proteins; Cognition Disorders; Female; Glycosylation; Humans; Lysine; Male; Neuropsychological Tests; Nitrates; Nitroso Compounds; Oxidation-Reduction; Reference Values; Tyrosine | 2005 |
Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Light; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Phosphorylation; Protein Processing, Post-Translational; Scattering, Radiation; Sodium Dodecyl Sulfate; tau Proteins; Tyrosine | 2005 |
Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animal Feed; Animals; Antioxidants; Astrocytes; Blotting, Western; Body Weight; Chromatography, High Pressure Liquid; Dietary Fats; Disease Susceptibility; Dopamine; Dopamine Agents; Glial Fibrillary Acidic Protein; Immunoblotting; Immunohistochemistry; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Obese; MPTP Poisoning; Neurons; Neurotoxicity Syndromes; Nitrates; Nitric Oxide; Nitrites; Obesity; Oxidative Stress; Phosphorylation; Substantia Nigra; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2005 |
Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632.
Topics: Amides; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Lung; Male; Malondialdehyde; Nitrates; Nitrites; Oleic Acid; Peroxidase; Protein Serine-Threonine Kinases; Pyridines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; Tyrosine; Up-Regulation | 2005 |
Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Cholesterol; Dopamine; Dopamine Agents; Homovanillic Acid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Microglia; Neostriatum; Nitrates; Nitric Oxide; Oxidants; Simvastatin; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Increased matrix metalloproteinases 2 and 9 in placenta of diabetic rats at midgestation.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Gestational Age; Immunohistochemistry; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitrates; Nitrites; Placenta; Pregnancy; Rats; Rats, Wistar; Tyrosine | 2005 |
Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry.
Topics: Aging; Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Molecular Sequence Data; Muscle Proteins; Muscle, Skeletal; Nanotechnology; Nitrates; Proteome; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Nitric oxide-nitric oxide synthase regulates key maturational events during chondrocyte terminal differentiation.
Topics: Alkaline Phosphatase; Animals; Blotting, Western; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chick Embryo; Chondrocytes; Collagen Type X; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cysteine; Gene Expression; Growth Plate; Guanylate Cyclase; Immunohistochemistry; Isoenzymes; Luciferases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Promoter Regions, Genetic; Recombinant Fusion Proteins; S-Nitrosoglutathione; S-Nitrosothiols; Sternum; Transfection; Tretinoin; Tyrosine | 2005 |
15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism.
Topics: Acetates; Animals; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Experimental; Female; Gestational Age; Lipid Metabolism; Nitrates; Nitrites; Peroxynitrous Acid; Placenta; PPAR gamma; Pregnancy; Prostaglandin D2; Rats; Rats, Wistar; Streptozocin; Tyrosine | 2005 |
The detection of nitrated tyrosine in neuropeptides: a MALDI matrix-dependent response.
Topics: Amino Acid Sequence; Animals; Aplysia; Molecular Sequence Data; Neuropeptides; Nitrates; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2005 |
Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.
Topics: Animals; Blood Pressure; Hemodynamics; Hypertension; Kidney; Male; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrites; Oxidative Stress; Oxidoreductases; Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Superoxides; Tyrosine | 2005 |
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Topics: alpha-Synuclein; Calpain; Chymotrypsin; Humans; Hydrolysis; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Parkinson Disease; Peptide Fragments; Peroxynitrous Acid; Recombinant Proteins; Solubility; Synucleins; Tyrosine | 2005 |
In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes.
Topics: Animals; Chromatography, High Pressure Liquid; Cinnamomum zeylanicum; Eugenol; Lipid Peroxidation; Microsomes, Liver; Nitrates; Oils, Volatile; Oxidation-Reduction; Peroxynitrous Acid; Rats; Tyrosine | 2005 |
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Time Factors; Tyrosine; Up-Regulation | 2005 |
Essential oils of commonly used plants as inhibitors of peroxynitrite-induced tyrosine nitration.
Topics: Humans; Laurus; Nitrates; Peroxynitrous Acid; Phytotherapy; Plant Leaves; Plant Oils; Tyrosine | 2005 |
Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity.
Topics: Actins; Aldehydes; Animals; Blotting, Southern; Blotting, Western; Doxorubicin; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mitochondria, Heart; Myocytes, Cardiac; Nitrates; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2005 |
LPS-induced tyrosine nitration of hepatic glutamine synthetase.
Topics: Animals; Glutamate-Ammonia Ligase; Lipopolysaccharides; Liver; Nitrates; Nitrosation; Rats; Tyrosine | 2005 |
Angiotensin II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Rats; Receptor, Angiotensin, Type 1; Tyrosine | 2005 |
Inhibition of nitric oxide production and protein tyrosine nitration contribute to neuroprotection by a novel calmodulin antagonist, DY-9760e, in the rat microsphere embolism.
Topics: Animals; Blotting, Western; Brain; Calmodulin; Cerebral Infarction; Indazoles; Injections, Intraperitoneal; Intracranial Embolism; Microdialysis; Microspheres; Neostriatum; Neuroprotective Agents; Nitrates; Nitric Oxide; Rats; Tyrosine | 2005 |
Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Chronic Disease; Cysteine; Disease Models, Animal; Female; Fetus; Free Radical Scavengers; Lung; Lung Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Papio; Pregnancy; S-Nitrosothiols; Tyrosine | 2005 |
Subtilisin QK, a fibrinolytic enzyme, inhibits the exogenous nitrite and hydrogen peroxide induced protein nitration, in vitro and in vivo.
Topics: Animals; Antioxidants; Bacillus subtilis; Cattle; Cell Line; Hemoglobins; Humans; Hydrogen Peroxide; Male; Mice; Nitrates; Nitrites; Oxidants; Oxidation-Reduction; Rats; Serum Albumin, Bovine; Subtilisins; Tyrosine | 2005 |
Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia.
Topics: Adaptation, Physiological; Animals; Apoptosis; Blood Pressure; Caspase 3; Creatine Kinase; Dietary Supplements; Enzyme Activation; Glutathione; Heart Rate; Heart Ventricles; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Nitrates; Nitroglycerin; Rats; Recovery of Function; Tyrosine; Vasodilation | 2005 |
Kidney immune cell infiltration and oxidative stress contribute to prenatally programmed hypertension.
Topics: Animals; Antioxidants; Cell Movement; Cyclic N-Oxides; Female; Hypertension, Renal; Immunosuppressive Agents; Kidney; Leukocytes; Male; Mycophenolic Acid; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Pregnancy; Rats; Spin Labels; Tyrosine | 2005 |
Site-specific nitration differentially influences tau assembly in vitro.
Topics: Biopolymers; Microscopy, Electron; Nitrates; Protein Processing, Post-Translational; tau Proteins; Tyrosine | 2005 |
Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; Embryo, Mammalian; Endothelin-1; Female; Immunohistochemistry; Nitrates; Nitric Oxide; Nitrites; Organogenesis; Pregnancy; Pregnancy in Diabetics; Prostaglandin D2; Rats; Rats, Wistar; Tyrosine | 2005 |
Peroxynitrite mediates TNF-alpha-induced endothelial barrier dysfunction and nitration of actin.
Topics: Actins; Albumins; Animals; Capillary Permeability; Cattle; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Lung; Microcirculation; Nitrates; Peroxynitrous Acid; Protein Isoforms; Rats; Tissue Distribution; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid | 2006 |
Hydrophobic tyrosyl probes for monitoring nitration reactions in membranes.
Topics: Cell Membrane; Chromatography, High Pressure Liquid; Endothelium; Molecular Probes; Nitrates; Oxidative Stress; Proteasome Endopeptidase Complex; Tyrosine | 2005 |
Mapping sites of tyrosine nitration by matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Angiotensin II; Humans; Nitrates; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2005 |
Effect of hereditary obesity on renal expressions of NO synthase, caveolin-1, AKt, guanylate cyclase, and calmodulin.
Topics: Animals; Body Weight; Calmodulin; Caveolin 1; Down-Regulation; Guanylate Cyclase; Immunohistochemistry; Kidney; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Obesity; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tyrosine | 2005 |
Structural characterisation of tyrosine-nitrated peptides by ultraviolet and infrared matrix-assisted laser desorption/ionisation Fourier transform ion cyclotron resonance mass spectrometry.
Topics: Amino Acid Sequence; Cyclotrons; Fourier Analysis; Infrared Rays; Ions; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Nitrates; Peptides; Protein Conformation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine; Ultraviolet Rays | 2005 |
Altered protein expression and protein nitration pattern during d-galactosamine-induced cell death in human hepatocytes: a proteomic analysis.
Topics: Apoptosis; Cell Death; Cells, Cultured; Galactosamine; Hepatocytes; Humans; Necrosis; Nitrates; Oxidative Stress; Proteins; Proteomics; Tyrosine | 2005 |
Autocatalytic tyrosine nitration of prostaglandin endoperoxide synthase-2 in LPS-stimulated RAW 264.7 macrophages.
Topics: Animals; Catalysis; Cell Line; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Nitrates; Prostaglandin-Endoperoxide Synthases; Tyrosine | 2006 |
Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; ATP Synthetase Complexes; Carbonic Anhydrase II; Female; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); Hippocampus; Humans; Male; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Oxidation-Reduction; Oxidative Stress; Phosphopyruvate Hydratase; Phosphorylation; Proteomics; Tyrosine; Voltage-Dependent Anion Channel 1 | 2006 |
Nitrotyrosine formation and apoptosis in rat models of ocular injury.
Topics: Animals; Apoptosis; Blotting, Western; Eye Injuries; In Situ Nick-End Labeling; Lipopolysaccharides; Male; Models, Animal; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Retina; Tyrosine | 2006 |
Nitration of profilin effects its interaction with poly (L-proline) and actin.
Topics: Actins; Animals; Cattle; Nitrates; Peptides; Peroxynitrous Acid; Profilins; Spleen; Tyrosine | 2005 |
The nitrate/nitrite ABC transporter of Phormidium laminosum: phosphorylation state of NrtA is not involved in its substrate binding activity.
Topics: Amino Acid Sequence; Anion Transport Proteins; ATP-Binding Cassette Transporters; Binding, Competitive; Cyanobacteria; Electrophoresis, Polyacrylamide Gel; Isoelectric Point; Kinetics; Mass Spectrometry; Molecular Sequence Data; Nitrate Transporters; Nitrates; Nitrites; Phosphorylation; Protein Binding; Protein Isoforms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2006 |
15N CIDNP investigations of the peroxynitric acid nitration of L-tyrosine and of related compounds.
Topics: Ascorbic Acid; Cysteine; Glutathione; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nitrates; Nitrogen; Nitrogen Isotopes; Phenols; Solvents; Temperature; Tyrosine | 2006 |
Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis.
Topics: Alkenes; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymphatic Metastasis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53; Tyrosine; Vascular Endothelial Growth Factor C | 2006 |
Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: a role for alpha-actinin nitration.
Topics: Actinin; Blood Platelets; Catechin; Cell Survival; Cells, Cultured; Cyclic GMP; Fibrinogen; Guanylate Cyclase; Humans; Nitrates; Nitric Oxide Donors; Nitroprusside; Platelet Adhesiveness; Solubility; Superoxide Dismutase; Thrombin; Tyrosine | 2006 |
Identification of ubiquitin nitration and oxidation using a liquid chromatography/mass selective detector system.
Topics: Biotechnology; Chromatography, Liquid; Mass Spectrometry; Methionine; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Trypsin; Tyrosine; Ubiquitin | 2005 |
Nitration of cardiac proteins is associated with abnormal cardiac chronotropic responses in rats with biliary cirrhosis.
Topics: Acetylcysteine; Animals; Enzyme Inhibitors; Heart Rate; Immunohistochemistry; Liver Cirrhosis, Biliary; Male; Microscopy, Electron; Muscle Proteins; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Osmolar Concentration; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Tyrosine | 2006 |
Protein tyrosine nitration is associated with cold- and drug-resistant microtubules in neuronal-like PC12 cells.
Topics: Animals; Antineoplastic Agents; Brain; Cell Differentiation; Cold Temperature; Cytoskeleton; Drug Resistance; Microtubules; Nerve Growth Factor; Nerve Tissue Proteins; Neurites; Nitrates; Nitric Oxide; Nocodazole; PC12 Cells; Rats; Tyrosine | 2006 |
Chronic beta-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Blotting, Western; C-Reactive Protein; Heart; Immunohistochemistry; In Situ Nick-End Labeling; Isoproterenol; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; RNA; Stress, Physiological; Tyrosine | 2006 |
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Humans; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Neutrophil Infiltration; Nitrates; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Stroke; Thromboembolism; Tissue Plasminogen Activator; Tyrosine; Uric Acid | 2007 |
Impact of angiotensin-converting enzyme inhibition on renal cortical nitrotyrosine content during increased extracellular glucose concentration.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Glucose; Kidney Cortex; Male; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Tyrosine | 2006 |
Production of nitric oxide and self-nitration of proteins during monocyte differentiation to dendritic cells.
Topics: Adult; Arginase; Cell Differentiation; Dendritic Cells; Female; Fluorescent Antibody Technique; Humans; Male; Monocytes; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Tyrosine | 2005 |
N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats.
Topics: Acetylcysteine; Animals; Blood Glucose; Blood Pressure; Blotting, Western; Cholesterol; Diabetes Mellitus, Experimental; Free Radical Scavengers; Heart Rate; Immunohistochemistry; Insulin; Isoprostanes; Male; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Stress, Physiological; Triglycerides; Tyrosine | 2006 |
Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Chlorogenic Acid; Endothelium, Vascular; Hydrogen Peroxide; Immunohistochemistry; In Vitro Techniques; Male; NADP; NADPH Oxidases; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Quinic Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Tyrosine; Vasodilation | 2006 |
Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase.
Topics: Animals; Blotting, Western; Chondrocytes; Dendritic Cells; Microscopy, Immunoelectron; Nitrates; Nitric Oxide Synthase Type II; Peroxisomes; Proteins; Rats; Reactive Oxygen Species; Subcellular Fractions; Tyrosine | 2006 |
HIV-1-induced pulmonary oxidative and nitrosative stress: exacerbated response to endotoxin administration in HIV-1 transgenic mouse model.
Topics: Animals; Cytokines; Glutathione; HIV Infections; HIV-1; Hydrogen Peroxide; Lipopolysaccharides; Lung; Mice; Mice, Transgenic; Nitrates; Nitrites; Nitrosation; Oxidative Stress; Pulmonary Edema; Tyrosine | 2006 |
Post-Translational Modifications of the P2X(4) purinergic receptor subtype in the human placenta are altered in preeclampsia.
Topics: Adult; Blotting, Western; Chorionic Villi; Female; Fluorescent Antibody Technique, Indirect; Glycosylation; Humans; Neuropeptides; Nitrates; Phosphorylation; Pre-Eclampsia; Pregnancy; Protein Processing, Post-Translational; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Tyrosine; Up-Regulation | 2007 |
Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis.
Topics: Airway Obstruction; Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Female; Fibrinolytic Agents; Infusions, Intravenous; Lung; Nitrates; Nitrites; Organ Size; Prospective Studies; Protein C; Pulmonary Edema; Random Allocation; Recombinant Proteins; Respiratory Function Tests; Sepsis; Sheep; Smoke Inhalation Injury; Tyrosine | 2006 |
Peroxynitrite treatment in vitro disables catalytic activity of recombinant p38 MAPK.
Topics: Amino Acid Sequence; Catalysis; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Nitrates; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Protein Isoforms; Protein Structure, Tertiary; Recombinant Proteins; Tyrosine | 2006 |
Mass spectrometry in demonstrating the site-specific nitration of hen egg white lysozyme by an improved electrochemical method.
Topics: Amino Acid Sequence; Animals; Chickens; Cyclotrons; Egg White; Electrochemistry; Hydrogen-Ion Concentration; Mass Spectrometry; Molecular Sequence Data; Muramidase; Nitrates; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2006 |
pH-dependent nitration of para-hydroxyphenylacetic acid in the stomach.
Topics: Acrylates; Adult; Female; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Middle Aged; Nitrates; Nitric Oxide; Phenols; Reference Values; Tyrosine | 2006 |
X-ray structural studies of the fungal laccase from Cerrena maxima.
Topics: Binding Sites; Copper; Crystallography, X-Ray; Fungal Proteins; Laccase; Molecular Structure; Nitrates; Polysaccharides; Protein Conformation; Tyrosine; Water | 2006 |
pH profile of cytochrome c-catalyzed tyrosine nitration.
Topics: Animals; Biomarkers; Catalysis; Cattle; Cytochromes c; Hydrogen Peroxide; Hydrogen-Ion Concentration; Nitrates; Nitrites; Oxidants; Oxidation-Reduction; Reactive Nitrogen Species; Serum Albumin, Bovine; Tyrosine | 2006 |
Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Female; Humans; Mice; Mice, Inbred BALB C; Neurofibrillary Tangles; Nitrates; tau Proteins; Tauopathies; Tyrosine | 2006 |
Protein tyrosine nitration induced by heme/hydrogen peroxide: inhibitory effect of hydroxycinnamoyl conjugates.
Topics: Asteraceae; Catalysis; Coumaric Acids; Heme; Hemeproteins; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Leukocytes; Nitrates; Phytotherapy; Tyrosine | 2007 |
Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II.
Topics: Acetylcholine; Adenosine; Angiotensin II; Animals; Cerebrovascular Circulation; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrosation; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides; Tyrosine; Vasodilator Agents; Vibrissae | 2007 |
The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets.
Topics: Blood Platelets; Humans; Lipopolysaccharides; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Platelet Activating Factor; Platelet Activation; Proteus mirabilis; Thrombin; Tyrosine | 2007 |
Modulation of protein tyrosine nitration and inflammatory mediators by isoprenylhydroquinone glucoside.
Topics: 3T3 Cells; Animals; Blotting, Western; Cell Survival; Cell-Free System; Cells, Cultured; Fibroblasts; Glucosides; Heme; Humans; Hydrogen Peroxide; Hydroquinones; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Mice; Neutrophils; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Reverse Transcriptase Polymerase Chain Reaction; Rhodamines; Serum Albumin, Bovine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Reversible inhibition of mammalian glutamine synthetase by tyrosine nitration.
Topics: Animals; Enzyme Activation; Glutamate-Ammonia Ligase; Nitrates; Oxidative Stress; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Sheep; Tyrosine | 2007 |
Light-induced changes in protein nitration in photoreceptor rod outer segments.
Topics: Animals; Antioxidants; Blotting, Western; Chromatography, Liquid; Darkness; Eye Proteins; Light; Male; Nitrates; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Rod Cell Outer Segment; Tandem Mass Spectrometry; Thiourea; Tyrosine | 2006 |
Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase.
Topics: Animals; Disease Models, Animal; Kidney; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar; Renal Circulation; Reperfusion Injury; Tyrosine; Xanthine Dehydrogenase | 2007 |
Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress.
Topics: Acute Disease; Animals; Doxorubicin; Heart Diseases; Iridoid Glucosides; Iridoids; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase Type II; Nitrosation; Oleaceae; Oxidative Stress; Pyrans; Rats; Rats, Wistar; Tyrosine | 2007 |
Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury.
Topics: Aldehydes; Animals; Brain; Brain Injuries; Calcium; Calpain; Cerebral Cortex; Cytoskeleton; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Spectrin; Time Factors; Tissue Distribution; Tyrosine | 2007 |
Peroxynitrite oxidizes erythrocyte membrane band 3 protein and diminishes its anion transport capacity.
Topics: Acetylcysteine; Anion Exchange Protein 1, Erythrocyte; Anions; Catechin; Erythrocytes; Hemoglobins; Humans; Ion Transport; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2007 |
Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.
Topics: Adolescent; Adult; Aged; Animals; Brain; Brain Injuries; Chemotaxis, Leukocyte; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nerve Degeneration; Nitrates; Nitric Oxide Synthase Type I; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2007 |
Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Amnesia; Biomarkers; Brain; Cognition Disorders; Disease Progression; Early Diagnosis; Female; Hippocampus; Humans; Immunohistochemistry; Male; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Parietal Lobe; Predictive Value of Tests; Prognosis; Tyrosine; Up-Regulation | 2007 |
The aromatic cage in the active site of monoamine oxidase B: effect on the structural and electronic properties of bound benzylamine and p-nitrobenzylamine.
Topics: Amino Acids, Aromatic; Animals; Benzylamines; Catalytic Domain; Electrons; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Nitrates; Nitro Compounds; Tyrosine | 2007 |
Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide.
Topics: Animals; Behavior, Animal; Blood Gas Analysis; Body Fluids; Bronchoalveolar Lavage Fluid; Hyperoxia; L-Lactate Dehydrogenase; Lung; Lung Diseases; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxygen; Pneumonia; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Survival Analysis; Tyrosine; Vagotomy | 2007 |
Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitro-N-nitrosoguanidine-treated thymocytes: implication for cytotoxicity.
Topics: Alkylating Agents; Animals; Apoptosis; Blotting, Western; Caspases; Cell Death; Cell Survival; Comet Assay; DNA Damage; DNA Fragmentation; Fluorescent Antibody Technique; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mitochondria; Nitrates; Nitric Oxide; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Superoxides; T-Lymphocytes; Tyrosine | 2007 |
Isohumulones derived from hops ameliorate renal injury via an anti-oxidative effect in Dahl salt-sensitive rats.
Topics: Animals; Antioxidants; Blood Pressure; Blotting, Western; Cyclopentanes; Humulus; Hypertension; Kidney Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Proteinuria; Rats; Rats, Inbred Dahl; Reactive Oxygen Species; Sodium Chloride; Tyrosine | 2007 |
Ceftazidime improves hemodynamics and oxygenation in ovine smoke inhalation injury and septic shock.
Topics: Animals; Anti-Bacterial Agents; Blood Pressure; Ceftazidime; Disease Models, Animal; Female; Heart Rate; Hemodynamics; Lung; Nitrates; Nitrites; Oxygen Consumption; Random Allocation; Sheep; Shock, Septic; Smoke Inhalation Injury; Tyrosine | 2007 |
Caveolae nitration of Janus kinase-2 at the 1007Y-1008Y site: coordinating inflammatory response and metabolic hormone readjustment within the somatotropic axis.
Topics: Amino Acid Sequence; Animals; Antibodies; Antioxidants; Aspartic Acid; Binding Sites; Cattle; Caveolae; Epitopes; Glutamic Acid; Inflammation; Insulin-Like Growth Factor I; Janus Kinase 2; Lipopolysaccharides; Molecular Sequence Data; Nitrates; Nitric Oxide Synthase Type III; Phosphorylation; Rabbits; RNA, Messenger; Stress, Physiological; Suppressor of Cytokine Signaling Proteins; Tyrosine; Vitamin E | 2007 |
Growth hormone (GH)-associated nitration of Janus kinase-2 at the 1007Y-1008Y epitope impedes phosphorylation at this site: mechanism for and impact of a GH, AKT, and nitric oxide synthase axis on GH signal transduction.
Topics: Animals; Binding Sites; Cattle; Cells, Cultured; Epitopes; Growth Hormone; Hepatocytes; Janus Kinase 2; Male; Nitrates; Nitric Oxide Synthase Type III; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Signal Transduction; Swine; Tyrosine | 2007 |
Endotoxemia produces coma and brain swelling in bile duct ligated rats.
Topics: Ammonia; Animals; Brain; Brain Edema; Capillaries; Cholestasis, Extrahepatic; Coma; Consciousness; Cytokines; Disease Models, Animal; Endotoxemia; Hyperammonemia; Ligation; Lipopolysaccharides; Liver Cirrhosis, Experimental; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron, Transmission; Nitrates; Nitrites; Rats; Rats, Sprague-Dawley; Tyrosine | 2007 |
L-arginine attenuates acute lung injury after smoke inhalation and burn injury in sheep.
Topics: Airway Obstruction; Animals; Arginine; Blood Pressure; Burns; Female; Hematocrit; Lung; Lung Injury; Nitrates; Nitrites; Random Allocation; Sheep; Smoke Inhalation Injury; Survival Analysis; Tyrosine; Urination | 2007 |
Regulation of cGMP-dependent protein kinase-mediated vasodilation by hypoxia-induced reactive species in ovine fetal pulmonary veins.
Topics: Animals; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fetus; Hypoxia; Isoenzymes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitrates; Nitrites; Peroxynitrous Acid; Pulmonary Veins; Reactive Nitrogen Species; Reactive Oxygen Species; Sheep; Time Factors; Tyrosine; Vasodilation | 2007 |
Investigation of tyrosine nitration and nitrosylation of angiotensin II and bovine serum albumin with electrospray ionization mass spectrometry.
Topics: Angiotensin II; Nitrates; Nitrogen; Reproducibility of Results; Sensitivity and Specificity; Serum Albumin, Bovine; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2007 |
Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration.
Topics: Binding Sites; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Nitrates; Oligopeptides; Peptide Fragments; Peroxynitrous Acid; Phosphorylation; Tandem Mass Spectrometry; Tyrosine | 2007 |
Inhibitory effect of curcuminoids and tetrahydrocurcuminoids on equine activated neutrophils and myeloperoxidase activity.
Topics: Animals; Benzothiazoles; Cell Separation; Cell Survival; Chlorides; Curcumin; Flavonoids; Horses; Immunohistochemistry; In Vitro Techniques; Luminescence; Neutrophil Activation; Nitrates; Oxidation-Reduction; Peroxidase; Phenols; Polyphenols; Reactive Oxygen Species; Sulfonic Acids; Taurine; Tyrosine | 2008 |
Tau is endogenously nitrated in mouse brain: identification of a tyrosine residue modified in vivo by NO.
Topics: Animals; Blotting, Western; Brain Chemistry; Electrophoresis, Gel, Two-Dimensional; Hydrogen-Ion Concentration; Immunoprecipitation; Isomerism; Mice; Nitrates; Nitric Oxide; PC12 Cells; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; tau Proteins; Tyrosine | 2008 |
PII is important in regulation of nitrogen metabolism but not required for heterocyst formation in the Cyanobacterium Anabaena sp. PCC 7120.
Topics: Anabaena; Bacterial Proteins; Electrophoresis, Gel, Two-Dimensional; Glutamate-Ammonia Ligase; Mass Spectrometry; Mutation; Nitrates; Nitrogen; Nitrogenase; PII Nitrogen Regulatory Proteins; Protein Conformation; Protein Structure, Tertiary; Synechocystis; Time Factors; Tyrosine | 2007 |
Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.
Topics: Animals; Arginase; Asthma; Collagen; Cytokines; Gene Expression Regulation, Enzymologic; Goblet Cells; Immunohistochemistry; Isoenzymes; Male; Mice; Nitrates; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger; Tyrosine; Up-Regulation | 2007 |
A DFT study of the nitric oxide and tyrosyl radical interaction: a proposed radical mechanism.
Topics: Catalysis; Chemistry, Physical; Free Radicals; Hydrogen Bonding; Imines; Ions; Models, Chemical; Models, Theoretical; Molecular Conformation; Nitrates; Nitric Oxide; Tyrosine; Water | 2007 |
Nitric oxide bioavailability and not production is first altered during the onset of insulin resistance in sucrose-fed rats.
Topics: Animals; Aorta; Biomarkers; Cyclic GMP; Cysteine; Diet; Diet Therapy; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Insulin Resistance; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Sucrose; Sweetening Agents; Tyrosine | 2007 |
Mass spectrometry analysis of in vitro nitration of a recombinant human IgG1 monoclonal antibody.
Topics: Antibodies, Monoclonal; Chromatography, Liquid; Glycopeptides; Glycosylation; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunoglobulin G; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Indicators and Reagents; Mass Spectrometry; Molecular Weight; Nitrates; Peptide Fragments; Peptide Mapping; Recombinant Proteins; Tetranitromethane; Trypsin; Tyrosine | 2008 |
Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity.
Topics: Adult; AIDS Dementia Complex; Biomarkers; Brain; Cohort Studies; Disease Progression; Down-Regulation; Enzyme Activation; Female; Humans; Intramolecular Oxidoreductases; Lipocalins; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrosation; Oxidative Stress; Predictive Value of Tests; Substance Abuse, Intravenous; Tyrosine; Up-Regulation | 2008 |
High glucose induced human umbilical vein endothelial cell injury: involvement of protein tyrosine nitration.
Topics: Animals; Cell Line; Cell Survival; Endothelial Cells; Glucose; Glutathione; Hemin; Humans; Hydrogen Peroxide; Lipid Peroxidation; Nitrates; Nitrites; Oxidants; Reactive Oxygen Species; Tyrosine; Umbilical Veins | 2008 |
How DMSO, a widely used solvent, affects spinal cord injury.
Topics: Animals; Aorta, Abdominal; Dimethyl Sulfoxide; Disease Models, Animal; Free Radical Scavengers; Ligation; Malondialdehyde; Neuroprotective Agents; Nitrates; Nitrites; Peroxidase; Rabbits; Reperfusion Injury; Solvents; Spinal Cord; Spinal Cord Ischemia; Time Factors; Tyrosine | 2008 |
A profound decrease in maternal arginine uptake provokes endothelial nitration in the pregnant rat.
Topics: Animals; Aorta, Thoracic; Arginine; Blotting, Northern; Blotting, Western; Cationic Amino Acid Transporter 1; Endothelium, Vascular; Enzyme Inhibitors; Female; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Immunohistochemistry; Immunoprecipitation; Leukocytes; Nitrates; Peroxynitrous Acid; Placenta; Pregnancy; Pregnancy, Animal; Protein Kinase C; Rats; RNA, Messenger; Tyrosine; Vitamin E | 2008 |
Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Coculture Techniques; Immunohistochemistry; Mice; Mice, Knockout; Mitochondria; Neuroglia; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
H2O2/nitrite-induced post-translational modifications of human hemoglobin determined by mass spectrometry: redox regulation of tyrosine nitration and 3-nitrotyrosine reduction by antioxidants.
Topics: Amino Acid Sequence; Antioxidants; Ascorbic Acid; Cysteine; Hemin; Hemoglobins; Humans; Hydrogen Peroxide; Methionine; Molecular Sequence Data; Nitrates; Nitrites; Oxidation-Reduction; Peroxidase; Protein Processing, Post-Translational; Reactive Nitrogen Species; Spectrometry, Mass, Electrospray Ionization; Trypsin; Tyrosine; Vitamin B 12 | 2008 |
S-nitrosylation of peroxiredoxin II E promotes peroxynitrite-mediated tyrosine nitration.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatography, Liquid; Lipid Peroxidation; Models, Biological; Nitrates; Peroxiredoxins; Peroxynitrous Acid; Plants, Genetically Modified; Tandem Mass Spectrometry; Tyrosine | 2007 |
Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitrite.
Topics: Blotting, Western; Cell Line, Tumor; Coculture Techniques; Epithelial Cells; Extracellular Space; Glutathione; Humans; Hydrogen Peroxide; Immunochemistry; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Peroxidase; Respiratory Mucosa; Tyrosine | 2008 |
p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
Topics: Abdomen; Animals; Calmodulin; Cardiotonic Agents; Caveolin 1; Chemokine CXCL1; Chemokine CXCL2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Estradiol; Heart Diseases; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Mitogen-Activated Protein Kinase 11; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Ventricular Function | 2008 |
Interaction of dicaffeoylquinic derivatives with peroxynitrite and other reactive nitrogen species.
Topics: Animals; Bicarbonates; Catechin; Cattle; Fibroblasts; Humans; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; Neutrophils; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Peroxynitrous Acid; Quinic Acid; Reactive Nitrogen Species; Serum Albumin, Bovine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tyrosine | 2008 |
Inhibition of myeloperoxidase-mediated protein nitration by tempol: Kinetics, mechanism, and implications.
Topics: Antioxidants; Catalysis; Cyclic N-Oxides; Humans; Kinetics; Nitrates; Peroxidase; Protein Processing, Post-Translational; Reactive Oxygen Species; Ribonucleases; Spin Labels; Tyrosine | 2008 |
Tyrosine nitration, dimerization, and hydroxylation by peroxynitrite in membranes as studied by the hydrophobic probe N-t-BOC-l-tyrosine tert-butyl ester.
Topics: Dimerization; Electron Spin Resonance Spectroscopy; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Liposomes; Models, Biological; Molecular Probe Techniques; Molecular Probes; Nitrates; Peroxynitrous Acid; Proteins; Spin Trapping; Tyrosine | 2008 |
A possible link between astrocyte activation and tau nitration in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Antibodies, Monoclonal; Antibody Specificity; Astrocytes; Brain; Female; Glial Fibrillary Acidic Protein; Gliosis; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Nitrates; Plaque, Amyloid; Protein Processing, Post-Translational; tau Proteins; Tyrosine | 2008 |
The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.
Topics: Amyloid beta-Peptides; Animals; Cognition Disorders; Cytoskeleton; Hippocampus; Male; Mice; Mice, Inbred ICR; Neurofilament Proteins; Nitrates; Phosphorylation; Serine; Tyrosine | 2008 |
Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury.
Topics: Amidines; Animals; Benzylamines; Blood Pressure; Chemokines; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fluid Therapy; Glutathione Transferase; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Adhesion Molecule-1; Isoenzymes; Liver; Liver Diseases; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Tyrosine; Wounds and Injuries | 2008 |
Denitration of L-type calcium channel.
Topics: Animals; Calcium Channels, L-Type; Cell Line; Humans; Mice; Muscle, Smooth; Nitrates; Phosphorylation; Tyrosine | 2008 |
Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics.
Topics: Amino Acid Sequence; Animals; Brain; Chromatography, Liquid; Endoplasmic Reticulum; Mass Spectrometry; Mice; Microsomes; Molecular Sequence Data; Nitrates; Peptides; Proteome; Proteomics; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2008 |
Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration.
Topics: Animals; Arginase; Boronic Acids; Bronchi; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Activation; Female; Inflammation Mediators; Metaplasia; Mice; Mice, Inbred BALB C; Mucus; Nitrates; Nitric Oxide; Nitrosation; Proteins; Respiratory Hypersensitivity; Tyrosine; Up-Regulation | 2008 |
Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications.
Topics: Alanine; Animals; Enzyme Inhibitors; Ethanol; Extracellular Signal-Regulated MAP Kinases; Gastric Mucosa; Liver Cirrhosis; MAP Kinase Kinase Kinases; Nitrates; Oxidative Stress; Peroxynitrous Acid; Quinolones; Rats; Rats, Sprague-Dawley; Signal Transduction; Stomach Diseases; Tyrosine | 2008 |
CXCR4 expression in papillary thyroid carcinoma: induction by nitric oxide and correlation with lymph node metastasis.
Topics: Carcinoma, Papillary; Cell Line, Tumor; Chemokine CXCL12; Enzyme Inhibitors; Humans; Immunohistochemistry; Lymphatic Metastasis; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroso Compounds; Receptors, CXCR4; RNA, Messenger; Thyroid Neoplasms; Tyrosine | 2008 |
Comparative studies on homocysteine and its metabolite-homocysteine thiolactone action in blood platelets in vitro.
Topics: Blood Platelets; Cells, Cultured; Dose-Response Relationship, Drug; Homocysteine; Homocystine; Humans; Nitrates; Platelet Activation; Platelet Aggregation; Protein Processing, Post-Translational; Superoxides; Thrombin; Tyrosine | 2008 |
Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model.
Topics: Amino Acids; Animals; Blotting, Western; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intra-Abdominal Fat; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Rats, Inbred F344; RNA, Messenger; Tyrosine | 2010 |
Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.
Topics: Animals; Antioxidants; Brain Chemistry; Cell Survival; Indicators and Reagents; Indole Alkaloids; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; PC12 Cells; Peroxynitrous Acid; Piperazines; Protective Agents; Rats; Structure-Activity Relationship; Tyrosine | 2008 |
The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism?
Topics: Acetylation; Bicarbonates; Electron Spin Resonance Spectroscopy; Electron Transport; Hydrogen Peroxide; Kinetics; Methionine; Nitrates; Peptides; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Tyrosine | 2009 |
Methylmalonate-induced seizures are attenuated in inducible nitric oxide synthase knockout mice.
Topics: Animals; Brain; Brain Mapping; Electroencephalography; Female; Male; Methylmalonic Acid; Mice; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Seizures; Sodium-Potassium-Exchanging ATPase; Succinate Dehydrogenase; Tyrosine | 2009 |
A rapid and selective mass spectrometric method for the identification of nitrated proteins.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, Liquid; Mass Spectrometry; Milk Proteins; Molecular Sequence Data; Nitrates; Oxidation-Reduction; Peptides; Proteins; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2008 |
UCP3 overexpression neutralizes oxidative stress rather than nitrosative stress in mouse myotubes.
Topics: Animals; Catalase; Glutathione Peroxidase; Hydrogen Peroxide; Ion Channels; Mice; Mitochondrial Proteins; Muscle Fibers, Skeletal; Nitrates; Nitrosation; Oxidative Stress; Peroxiredoxins; Superoxide Dismutase; Tyrosine; Uncoupling Protein 3 | 2009 |
Attenuated PGI2 synthesis in obese Zucker rats.
Topics: Animals; Arachidonic Acid; Blotting, Western; Cell Separation; Epoprostenol; Fluorescent Antibody Technique; In Vitro Techniques; Male; Microcirculation; Myocytes, Smooth Muscle; Nitrates; Obesity; Physical Conditioning, Animal; Rats; Rats, Zucker; Receptors, Epoprostenol; Receptors, Thromboxane A2, Prostaglandin H2; Tyrosine | 2009 |
Impaired mitochondrial respiration and protein nitration in the rat hippocampus after acute inhalation of combustion smoke.
Topics: Acute Disease; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Hippocampus; Male; Mass Spectrometry; Mitochondria; Nerve Tissue Proteins; Nitrates; Oxygen Consumption; Proteomics; Rats; Rats, Sprague-Dawley; Smoke Inhalation Injury; Subcellular Fractions; Succinates; Tyrosine | 2009 |
Glucose-mediated tyrosine nitration in adipocytes: targets and consequences.
Topics: 3T3-L1 Cells; Active Transport, Cell Nucleus; Adipocytes; Animals; Cell Nucleus; Fatty Acid-Binding Proteins; Glucose; Mice; Nitrates; Oxidation-Reduction; Oxidative Stress; Palmitic Acid; Protein Binding; Protein Processing, Post-Translational; Tyrosine | 2009 |
Inactivation of rabbit muscle glycogen phosphorylase b by peroxynitrite revisited: does the nitration of Tyr613 in the allosteric inhibition site control enzymatic function?
Topics: Allosteric Site; Amino Acid Sequence; Animals; Cysteine; Glycogen Phosphorylase, Muscle Form; Kinetics; Models, Molecular; Molecular Sequence Data; Muscle, Skeletal; Nitrates; Peptide Fragments; Peroxynitrous Acid; Protein Conformation; Rabbits; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2009 |
Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target.
Topics: Animals; Blotting, Western; Electron Transport Complex I; Electrophoresis, Gel, Two-Dimensional; Mice; Mitochondria, Heart; Mitochondrial Proteins; Myocardial Reperfusion Injury; Nitrates; Proteomics; Tandem Mass Spectrometry; Tyrosine | 2009 |
[Changes of NO2-/NO3- and nitration tyrosine concentrations in induced sputum of silicosis patients].
Topics: Adult; Humans; Middle Aged; Nitrates; Nitrites; Silicosis; Sputum; Tyrosine | 2009 |
Does the unfavorable pharmacokinetic and pharmacodynamic profile of the iNOS inhibitor GW273629 lead to inefficacy in acute migraine?
Topics: Adult; Area Under Curve; Female; Half-Life; Humans; Male; Migraine Disorders; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Sulfones; Tyrosine | 2009 |
Role of oxidative stress in elevated blood pressure induced by high free fatty acids.
Topics: Animals; Blood Pressure; Fatty Acids, Nonesterified; Glucose Clamp Technique; Glutathione; Hypertension; In Vitro Techniques; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tyrosine | 2009 |
Nitrosative stress, protein tyrosine nitration, PARP activation and NAD depletion in the kidneys of rats after single dose of cyclophosphamide.
Topics: Animals; Cyclophosphamide; DNA Damage; Down-Regulation; Enzyme Activation; Immunohistochemistry; Injections, Intraperitoneal; Kidney; Male; NAD; Nitrates; Nitrites; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reactive Nitrogen Species; Superoxide Dismutase; Time Factors; Tyrosine | 2009 |
Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage.
Topics: Actin Cytoskeleton; Animals; Avena; Colon; Colonic Diseases; Cytoskeleton; Edible Grain; Ethanol; Intestinal Mucosa; Male; Models, Biological; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Permeability; Peroxidase; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Tight Junctions; Tyrosine | 2009 |
Erythropoietin attenuates lung injury in lipopolysaccharide treated rats.
Topics: Animals; Erythropoietin; Lipopolysaccharides; Lung; Lung Injury; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Tyrosine | 2009 |
Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids.
Topics: Animals; Antioxidants; Flavonoids; Glucose; Glucose Oxidase; Lipid Peroxidation; Male; Myocardium; Nitrates; Oxidation-Reduction; Proteins; Rats; Rats, Wistar; Tyrosine | 2009 |
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production.
Topics: Aging; Amino Acid Sequence; Animals; Brain; Coenzyme A-Transferases; Cytochromes c; Energy Metabolism; Male; Mitochondria; Mitochondrial Proteins; Mitochondrial Proton-Translocating ATPases; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; Reactive Nitrogen Species; Tandem Mass Spectrometry; Tyrosine | 2009 |
Aminoguanidine alleviates radiation-induced small-bowel damage through its antioxidant effect.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Deoxyguanosine; Diarrhea; Dose-Response Relationship, Drug; Guanidines; HeLa Cells; Humans; Intestinal Mucosa; Intestine, Small; Male; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Radiation Injuries; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley; Tyrosine | 2009 |
Mechanisms of peroxynitrite-mediated nitration of tyrosine.
Topics: Carbon Dioxide; Carbonates; Hydroxyl Radical; Nitrates; Nitrogen Dioxide; Peroxynitrous Acid; Tyrosine | 2009 |
Understanding peroxynitrite biochemistry and its potential for treating human diseases.
Topics: Bacteria; Biochemistry; Cell Death; Disease; Humans; Macrophages, Alveolar; Nitrates; Nitrophenols; Peroxynitrous Acid; Superoxide Dismutase; Superoxides; Tyrosine | 2009 |
Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis.
Topics: Air Pollutants; Animals; Aorta; Atherosclerosis; Blood Pressure; DNA Damage; DNA, Mitochondrial; Heart Rate; Lung Diseases; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidants; Oxidative Stress; Ozone; Superoxide Dismutase; Tyrosine | 2009 |
Glucose-modulated tyrosine nitration in beta cells: targets and consequences.
Topics: Animals; Chaperonin 60; Diabetes Mellitus; Glucose; Humans; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Islets of Langerhans; Nitrates; Pancreatic Neoplasms; Prediabetic State; Tyrosine | 2009 |
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.
Topics: Cell Line; Epigenesis, Genetic; Histone Deacetylase 2; Histone Deacetylases; Humans; Nitrates; Oxidative Stress; Proteasome Endopeptidase Complex; Repressor Proteins; Tyrosine | 2009 |
Effects of peroxynitrite-induced protein tyrosine nitration on insulin-stimulated tyrosine phosphorylation in HepG2 cells.
Topics: Cell Extracts; Electrophoresis, Polyacrylamide Gel; Hep G2 Cells; Humans; Insulin; Nitrates; Peroxynitrous Acid; Phosphorylation; Proteins; Subcellular Fractions; Tyrosine | 2009 |
Nitrated type III collagen as a biological marker of nitric oxide-mediated synovial tissue metabolism in osteoarthritis.
Topics: Aged; Arthritis, Rheumatoid; Biomarkers; Collagen Type I; Collagen Type III; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitrates; Osteoarthritis, Knee; Peptides; Synovial Membrane; Tyrosine | 2009 |
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Pressure; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypertension; In Vitro Techniques; Leupeptins; Mice; Mice, Inbred C57BL; Nitrates; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Transfection; Tyrosine; Vasodilation | 2009 |
Protein nitration during defense response in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Mass Spectrometry; Nitrates; Nitrosation; Plant Diseases; Proteomics; Tyrosine | 2009 |
Nitration of tyrosine residues 368 and 345 in the beta-subunit elicits FoF1-ATPase activity loss.
Topics: Amino Acid Sequence; Animals; Enzyme Activation; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrates; Protein Structure, Secondary; Protein Subunits; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tyrosine | 2009 |
Detection of 3-nitrotyrosine-modified human leukocyte antigen-G in biological fluids.
Topics: Body Fluids; Enzyme-Linked Immunosorbent Assay; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Nitrates; Nitric Oxide; Nitrites; Protein Multimerization; Protein Processing, Post-Translational; Tyrosine | 2009 |
In vivo protein tyrosine nitration in S. cerevisiae: identification of tyrosine-nitrated proteins in mitochondria.
Topics: Mitochondria; Mitochondrial Proteins; Nitrates; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tyrosine | 2009 |
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Lewy Bodies; Mass Spectrometry; Models, Biological; Monoamine Oxidase; Nitrates; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Tyrosine | 2009 |
Protein targets of tyrosine nitration in sunflower (Helianthus annuus L.) hypocotyls.
Topics: Adenosylhomocysteinase; Helianthus; Hypocotyl; Nitrates; Plant Proteins; Protein Processing, Post-Translational; Protein Structure, Quaternary; Protein Transport; Tyrosine | 2009 |
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion.
Topics: Blood Platelets; Blood Proteins; Cell Adhesion; Enzyme Inhibitors; Fibrinogen; Free Radical Scavengers; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Peroxynitrous Acid; Solubility; Superoxides; Thrombin; Tyrosine | 2010 |
Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma.
Topics: Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Child; Female; Humans; Male; Multivariate Analysis; Nitrates; Nitric Oxide; Nitrites; Respiratory Mucosa; Spirometry; Tyrosine | 2009 |
Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury.
Topics: Airway Obstruction; Animals; Cell Nucleus; Enzyme Activation; Hemodynamics; Indazoles; Interleukin-8; Lung Injury; Malondialdehyde; Nitrates; Nitric Oxide Synthase Type I; Nitrites; Peroxidase; Poly(ADP-ribose) Polymerases; Pressure; Regional Blood Flow; Respiratory Function Tests; Sheep; Survival Analysis; Trachea; Transcription Factor RelA; Tyrosine | 2010 |
Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation.
Topics: Animals; Anticholesteremic Agents; Biomarkers; Cholesterol, LDL; Hemodynamics; Hypercholesterolemia; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitrites; Oxidative Stress; Rabbits; Simvastatin; Tyrosine | 2010 |
Redox balance and cellular inflammation in the diaphragm, limb muscles, and lungs of mechanically ventilated rats.
Topics: Animals; Antioxidants; Biomarkers; Catalase; Diaphragm; Immunohistochemistry; Inflammation; Lung; Malondialdehyde; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Nitrates; Oxidative Stress; Protein Carbonylation; Rats; Respiration, Artificial; Superoxide Dismutase; Tidal Volume; Tyrosine; Ventilator-Induced Lung Injury | 2010 |
Chemical labeling and enrichment of nitrotyrosine-containing peptides.
Topics: Animals; Cattle; Mass Spectrometry; Nitrates; Peptide Fragments; Peptides; Protein Processing, Post-Translational; Proteomics; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2010 |
Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins.
Topics: Animals; Crosses, Genetic; DNA Primers; Enzyme Induction; Fat Emulsions, Intravenous; Female; Glucose; Glucose Clamp Technique; Hyperinsulinism; Infusions, Intravenous; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Proto-Oncogene Proteins c-akt; RNA; Signal Transduction; Tyrosine | 2010 |
L-arginine enhances nitrative stress and exacerbates tumor necrosis factor-alpha toxicity to human endothelial cells in culture: prevention by propofol.
Topics: Apoptosis; Arginine; Cell Line; Cell Survival; Endothelial Cells; Enzyme Inhibitors; Glutathione Peroxidase; Guanidines; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroarginine; Oxidative Stress; Propofol; Superoxide Dismutase; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Biological effect markers in exhaled breath condensate and biomonitoring in welders: impact of smoking and protection equipment.
Topics: Adult; Air Pollutants, Occupational; Aluminum; Biomarkers; Breath Tests; Chromium; Environmental Monitoring; Exhalation; Hazardous Substances; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxyproline; Male; Malondialdehyde; Middle Aged; Nickel; Nitrates; Nitrites; Nitroso Compounds; Occupational Exposure; Proline; Respiratory Protective Devices; Smoking; Statistics, Nonparametric; Tyrosine; Welding; Young Adult | 2010 |
Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging.
Topics: Adenosine Triphosphate; Age Factors; Aging; Analysis of Variance; Animals; Binding Sites; Blotting, Western; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Immunoprecipitation; Liver; Male; Mitochondria; Mitochondrial Proton-Translocating ATPases; Nitrates; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2010 |
Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress.
Topics: Animals; Animals, Newborn; Brain; Hypercapnia; Neurodegenerative Diseases; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Nitroarginine; Oxygen; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
New therapeutic and biomarker discovery for peripheral diabetic neuropathy: PARP inhibitor, nitrotyrosine, and tumor necrosis factor-{alpha}.
Topics: Animals; Blotting, Western; Diabetic Neuropathies; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Male; Nitrates; Nitrites; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms.
Topics: Angiotensin II; Animals; Cells, Cultured; Glucose Transporter Type 4; Humans; Insulin; Insulin Receptor Substrate Proteins; Mitogen-Activated Protein Kinase 3; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitrates; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Tyrosine | 2010 |
Neonatal asphyxia induces the nitration of cardiac myosin light chain 2 that is associated with cardiac systolic dysfunction.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blotting, Western; Cardiac Myosins; Electrophoresis, Gel, Two-Dimensional; Heart Failure; Hemodynamics; Humans; Immunoprecipitation; Infant, Newborn; Myosin Light Chains; Nitrates; Nitrites; Swine; Tyrosine | 2010 |
Comprehensive feature analysis for sample classification with comprehensive two-dimensional LC.
Topics: 5-Hydroxytryptophan; Algorithms; Chromatography, Liquid; Humans; Indoleacetic Acids; Indoles; Nitrates; Tryptophan; Tyrosine | 2010 |
Peroxynitrite and hemoglobin-mediated nitrative/oxidative modification of human plasma protein: effects of some flavonoids.
Topics: Antioxidants; Blood Proteins; Flavonoids; Free Radical Scavengers; Hemoglobins; Humans; Molecular Structure; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2010 |
Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Down-Regulation; Losartan; Male; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Osmolar Concentration; Oxidation-Reduction; Rats; Rats, Inbred SHR; Retina; Superoxide Dismutase; Tyrosine; Up-Regulation | 2010 |
Nitrative inactivation of thioredoxin-1 increases vulnerability of diabetic hearts to ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Heart; Hyperglycemia; Immunoblotting; Immunoprecipitation; Mice; Myocardial Reperfusion Injury; Nitrates; Nitrosation; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Thioredoxins; Tyrosine | 2010 |
Effect of CRH on NO bioavailability, ROS production and antioxidant defense systems in endothelial EAhy926 cells.
Topics: Antioxidants; Catalase; Cell Line; Corticotropin-Releasing Hormone; Culture Media, Conditioned; Endothelial Cells; Glutathione; Humans; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Peptide Fragments; Peptides, Cyclic; Pyrimidines; Pyrroles; Reactive Oxygen Species; Receptors, Corticotropin-Releasing Hormone; Superoxide Dismutase; Tyrosine | 2010 |
Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy.
Topics: Adult; Aged; Amino Acid Transport System X-AG; Biomarkers; Cerebral Cortex; Excitatory Amino Acid Transporter 2; Female; Glutamate-Ammonia Ligase; Guanosine; Hepatic Encephalopathy; HSP27 Heat-Shock Proteins; Humans; Liver Cirrhosis; Male; Middle Aged; Nitrates; Oxidative Stress; RNA; Tyrosine | 2010 |
Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Interleukin-8; Lung; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Poly Adenosine Diphosphate Ribose; Reverse Transcriptase Polymerase Chain Reaction; Sepsis; Sheep; Time Factors; Tyrosine | 2010 |
Variations in systemic biomarkers of oxidative/nitrosative stress and DNA damage before and during the consequent two cycles of chemotherapy in breast cancer patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Biomarkers, Tumor; Breast Neoplasms; Deoxyguanosine; DNA Damage; Female; Humans; Middle Aged; Nitrates; Nitrites; Nitrosation; Oxidation-Reduction; Oxidative Stress; Prognosis; Thiobarbituric Acid Reactive Substances; Tyrosine | 2010 |
Normobaric hyperoxia delays and attenuates early nitric oxide production in focal cerebral ischemic rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Hyperoxia; Ischemic Attack, Transient; Male; Middle Cerebral Artery; Nitrates; Nitric Acid; Nitrites; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
Internal exposure, effect monitoring, and lung function in welders after acute short-term exposure to welding fumes from different welding processes.
Topics: Adult; Air Pollutants, Occupational; Breath Tests; Chromium; Cross-Over Studies; Environmental Monitoring; Humans; Iron; Male; Middle Aged; Nickel; Nitrates; Nitrites; Occupational Exposure; Osteopontin; Respiratory Function Tests; Respiratory Physiological Phenomena; Tyrosine; Welding; Young Adult | 2010 |
Probing the mechanisms of electron capture dissociation mass spectrometry with nitrated peptides.
Topics: Amino Acid Sequence; Electrons; Nitrates; Peptides; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2010 |
Using blood pressure telemetry to assess acute changes in arterial stiffness in rats after nitric oxide synthase inhibition or environmental tobacco smoke exposure.
Topics: Animals; Arteries; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Elasticity; Environmental Exposure; Enzyme Inhibitors; Male; Nicotiana; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Smoke; Telemetry; Tyrosine; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
Protein pattern of Xenopus laevis embryos grown in simulated microgravity.
Topics: Actin-Related Protein 3; Actins; Animals; Cytoskeletal Proteins; Electrophoresis, Gel, Two-Dimensional; Embryo, Nonmammalian; Embryonic Development; Nitrates; Phosphorylation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stathmin; Tubulin; Tyrosine; Weightlessness; Weightlessness Simulation; Xenopus laevis; Xenopus Proteins | 2011 |
Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death.
Topics: Alanine Transaminase; Animals; Bilirubin; Death; Enzyme Inhibitors; Graft Rejection; Graft Survival; Imines; Liver; Liver Transplantation; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Necrosis; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Reactive Nitrogen Species; Tyrosine | 2010 |
Identification of tyrosine-nitrated proteins in HT22 hippocampal cells during glutamate-induced oxidative stress.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Glutamic Acid; Hippocampus; Mice; Nitrates; Nitro Compounds; Oxidative Stress; Proteins; Tyrosine | 2010 |
Analysis of nitrated proteins and tryptic peptides by HPLC-chip-MS/MS: site-specific quantification, nitration degree, and reactivity of tyrosine residues.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Molecular Sequence Data; Nitrates; Ovalbumin; Peptide Mapping; Peptides; Serum Albumin, Bovine; Tandem Mass Spectrometry; Trypsin; Tyrosine | 2011 |
The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation.
Topics: Aging; Animals; Blotting, Western; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Endotoxemia; Extracellular Space; Inflammation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Tyrosine | 2011 |
Changes in nitric oxide, cGMP, and nitrotyrosine concentrations over skin along the meridians in obese subjects.
Topics: Acupuncture Points; Adult; Cyclic GMP; Cyclic N-Oxides; Female; Humans; Imidazoles; Male; Nitrates; Nitric Oxide; Nitrites; Obesity; Skin; Tyrosine | 2011 |
The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25-35 into the temporal cortex.
Topics: Amyloid beta-Peptides; Animals; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Guanidines; Hippocampus; Indazoles; Male; Maze Learning; Memory; Memory Disorders; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Rats; Rats, Wistar; Temporal Lobe; Tyrosine | 2011 |
Factors influencing protein tyrosine nitration--structure-based predictive models.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Hydrogen Bonding; Magnetic Resonance Imaging; Models, Chemical; Models, Molecular; Molecular Structure; Nitrates; Nitrites; Nitrogen; Oxidative Stress; Protein Structure, Secondary; Protein Structure, Tertiary; Tyrosine | 2011 |
Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Amylases; Animals; Apoptosis; Ascitic Fluid; Aspartate Aminotransferases; bcl-2-Associated X Protein; Bicarbonates; Bilirubin; Blood Gas Analysis; Body Weight; Cell Count; Creatinine; Fas Ligand Protein; Hydrogen-Ion Concentration; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-1beta; Kidney; Lipase; Liver; Lung; Male; Mice; Mice, Inbred Strains; Multiple Organ Failure; Nitrates; Nitrites; P-Selectin; Pancreas; Phosphodiesterase 3 Inhibitors; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyridones; Survival Analysis; Tumor Necrosis Factor-alpha; Tyrosine; Zymosan | 2011 |
Selective screening of tyrosine-nitrated peptides in tryptic mixtures by in-source photodissociation at 355 nm in matrix-assisted laser desorption ionization.
Topics: Amino Acid Sequence; Nitrates; Peptide Mapping; Photochemical Processes; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine; Ultraviolet Rays | 2011 |
Melatonin improves mitochondrial respiratory chain activity and liver morphology in ob/ob mice.
Topics: Animals; Blotting, Western; Body Weight; Electron Transport Chain Complex Proteins; Fatty Liver; Histocytochemistry; Liver; Male; Melatonin; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria, Liver; Nitrates; Oxidative Stress; Peroxynitrous Acid; Protein Subunits; Tyrosine | 2011 |
In vivo protein tyrosine nitration in Arabidopsis thaliana.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Arabidopsis; Arabidopsis Proteins; Blotting, Western; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Immunoprecipitation; Nitrates; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tyrosine | 2011 |
Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding.
Topics: Allosteric Regulation; alpha-Synuclein; Humans; Hydrodynamics; Lipid Bilayers; Membrane Lipids; Mutation; Nitrates; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Binding; Protein Structure, Secondary; Tyrosine | 2011 |
Resveratrol preserves cardiac function, but does not prevent endothelial dysfunction or pulmonary inflammation after environmental tobacco smoke exposure.
Topics: Administration, Oral; Animals; Aorta, Abdominal; Blood Pressure; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Cardiovascular Physiological Phenomena; Cotinine; Cytochrome P-450 CYP1A1; Echocardiography; Endothelium, Vascular; Environmental Exposure; Leukocyte Count; Leukocyte Elastase; Male; Nitrates; Nitrites; Oxidative Stress; Resveratrol; Stilbenes; Swine; Tobacco Smoke Pollution; Tyrosine; Ventricular Function, Left | 2011 |
High temperature triggers the metabolism of S-nitrosothiols in sunflower mediating a process of nitrosative stress which provokes the inhibition of ferredoxin-NADP reductase by tyrosine nitration.
Topics: Aldehyde Oxidoreductases; Arginine; Ferredoxin-NADP Reductase; Gene Expression Regulation, Plant; Helianthus; Hot Temperature; Hypocotyl; Lipid Peroxides; Nitrate Reductase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitrosation; Peroxynitrous Acid; Photosynthesis; Proteomics; S-Nitrosoglutathione; S-Nitrosothiols; Stress, Physiological; Superoxides; Tyrosine | 2011 |
Is there a trigger role of peroxynitrite in the anti-arrhythmic effect of ischaemic preconditioning and peroxynitrite infusion?
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Coronary Vessels; Dogs; Female; Heart Ventricles; Hemodynamics; Hydrogen-Ion Concentration; Infusions, Intra-Arterial; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Nitrates; Nitrites; Peroxynitrous Acid; Superoxides; Time Factors; Tyrosine; Uric Acid | 2011 |
Antibody-free detection of protein tyrosine nitration in tissue sections.
Topics: Animals; Colon; Frozen Sections; Guinea Pigs; Humans; Immunohistochemistry; Lung; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Nitrates; Paraffin Embedding; Proteins; Tyrosine | 2011 |
CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation.
Topics: Acute Disease; Adenosine; Adenosine A2 Receptor Agonists; Animals; bcl-2-Associated X Protein; Carrageenan; Cytokines; Enzyme Activation; Fas Ligand Protein; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Mice; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide Synthase Type II; Nitrites; P-Selectin; Peroxidase; Phenethylamines; Pleurisy; Pneumonia; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Receptor, Adenosine A2A; Transcription Factor RelA; Tyrosine | 2011 |
Lipopolysaccharide-induced mitochondrial DNA depletion.
Topics: Aconitate Hydratase; Adenosine Triphosphate; Alanine Transaminase; Animals; ATP Synthetase Complexes; DNA-Binding Proteins; DNA, Mitochondrial; Electron Transport Complex I; Electron Transport Complex III; Electron Transport Complex IV; Hep G2 Cells; High Mobility Group Proteins; Humans; Interferon-beta; Iron; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Reactive Oxygen Species; Sepsis; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Toll-Like Receptor 4; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Interplay of endothelial and inducible nitric oxide synthases modulates the vascular response to ischaemia-reperfusion in the rabbit lung.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Lung; NADPH Oxidases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Phosphorylation; Pulmonary Artery; Pulmonary Circulation; Rabbits; Reactive Nitrogen Species; Reperfusion Injury; Respiration, Artificial; Time Factors; Tyrosine; Vascular Resistance; Vasoconstriction | 2012 |
Tyrosine nitration limits stretch-induced CD40 expression and disconnects CD40 signaling in human endothelial cells.
Topics: CD40 Antigens; Cells, Cultured; Endothelial Cells; Gene Expression Regulation; Hemodynamics; Humans; Inflammation; Nitrates; Nitro Compounds; Protein Processing, Post-Translational; Reactive Oxygen Species; Signal Transduction; Stress, Mechanical; Tensile Strength; Tyrosine | 2011 |
Evaluation of urinary biomarkers of oxidative/nitrosative stress in children with Down syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Biomarkers; Child; Child, Preschool; Deoxyguanosine; Dinoprost; Down Syndrome; Female; Glycation End Products, Advanced; Humans; Hydrogen Peroxide; Hypothyroidism; Lipid Peroxidation; Male; Nitrates; Nitrites; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Tyrosine | 2011 |
Protein tyrosine nitration in the cell cycle.
Topics: Cell Cycle; Cell Line, Tumor; G1 Phase; Humans; Nitrates; Protein Processing, Post-Translational; Proteins; Resting Phase, Cell Cycle; Tyrosine | 2011 |
Aminoguanidine, a selective nitric oxide synthase inhibitor, attenuates cyclophosphamide-induced renal damage by inhibiting protein nitration and poly(ADP-Ribose) polymerase activation.
Topics: Animals; Cyclophosphamide; Enzyme Activation; Enzyme Inhibitors; Guanidines; Kidney; Male; Nitrates; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine | 2011 |
Inhibition of peroxynitrite- and peroxidase-mediated protein tyrosine nitration by imidazole-based thiourea and selenourea derivatives.
Topics: Animals; Cattle; Crystallography, X-Ray; Imidazoles; Models, Molecular; Molecular Structure; Nitrates; Organoselenium Compounds; Peroxidase; Peroxynitrous Acid; Serum Albumin, Bovine; Stereoisomerism; Thiourea; Tyrosine; Urea | 2011 |
Glutamine synthetase is a molecular target of nitric oxide in root nodules of Medicago truncatula and is regulated by tyrosine nitration.
Topics: Amino Acid Sequence; Catechin; Enzyme Activation; Glutamate-Ammonia Ligase; Iodoacetamide; Medicago truncatula; Models, Biological; Molecular Sequence Data; Nitrates; Nitric Oxide; Nitroprusside; Nitrosation; Root Nodules, Plant; S-Nitrosoglutathione; Sequence Alignment; Tetranitromethane; Tyrosine | 2011 |
Oxidative modification of native protein residues using cerium(IV) ammonium nitrate.
Topics: Cerium; Models, Molecular; Molecular Structure; Nitrates; Oxidation-Reduction; Polyethylene Glycols; Proteins; Tryptophan; Tyrosine | 2011 |
Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin.
Topics: Amino Acid Sequence; Animals; Arabidopsis Proteins; Cytochromes c; Heme; Horses; Humans; Iron; Models, Molecular; Molecular Sequence Data; Nitrates; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Reactive Nitrogen Species; Reactive Oxygen Species; Sequence Alignment; Tyrosine | 2011 |
Ishemia-reperfusion enhances GAPDH nitration in aging skeletal muscle.
Topics: Aging; Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Mass Spectrometry; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Nitrates; Reperfusion Injury; RNA, Messenger; Tyrosine | 2011 |
Selective tau tyrosine nitration in non-AD tauopathies.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Antibodies, Monoclonal; Female; Humans; Immunohistochemistry; Male; Middle Aged; Neurons; Nitrates; Phosphorylation; Pick Disease of the Brain; Supranuclear Palsy, Progressive; tau Proteins; Tauopathies; Tyrosine | 2012 |
Beetroot betalain inhibits peroxynitrite-mediated tyrosine nitration and DNA strand cleavage.
Topics: Beta vulgaris; Betalains; DNA Breaks; Free Radical Scavengers; Nitrates; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2012 |
Subtotal nephrectomy plus coronary ligation leads to more pronounced damage in both organs than either nephrectomy or coronary ligation.
Topics: Animals; Blood Pressure; Cardio-Renal Syndrome; Coronary Stenosis; Disease Models, Animal; Gene Expression; Heart Failure; Ligation; Male; Myocarditis; Nephrectomy; Nephritis; Nitrates; Nitrites; Peptidyl-Dipeptidase A; Prorenin Receptor; Rats; Rats, Inbred Lew; Receptors, Cell Surface; Renal Insufficiency, Chronic; Renin; Thiobarbituric Acid Reactive Substances; Tyrosine; Ultrasonography | 2012 |
The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye.
Topics: Animals; Caspase 3; Cytokines; Electroretinography; Endothelin-1; Glutathione; Hemodynamics; Intraocular Pressure; Intravitreal Injections; Laser-Doppler Flowmetry; Male; Nitrates; Nitric Oxide Donors; Ophthalmic Artery; Optic Disk; Rabbits; Reperfusion Injury; Retina; Retinal Diseases; Superoxide Dismutase; Tonometry, Ocular; Triamcinolone Acetonide; Tyrosine | 2012 |
Exercise training blunts oxidative stress in sickle cell trait carriers.
Topics: Adult; Analysis of Variance; Biomarkers; Case-Control Studies; Catalase; E-Selectin; Endothelium, Vascular; Exercise; Exercise Test; France; Glutathione Peroxidase; Heterozygote; Humans; Male; Malondialdehyde; Nitrates; Nitrites; Oxidative Stress; P-Selectin; Protein Carbonylation; Sickle Cell Trait; Superoxide Dismutase; Time Factors; Tyrosine; Young Adult | 2012 |
A non-damaging method to analyze the configuration and dynamics of nitrotyrosines in proteins.
Topics: Cytochromes c; Nitrates; Nuclear Magnetic Resonance, Biomolecular; Peroxynitrous Acid; Proteins; Tyrosine | 2012 |
Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Mice; Mitochondria, Liver; Mitochondrial Proteins; Models, Molecular; Molecular Sequence Data; Nitrates; Peroxynitrous Acid; Protein Structure, Secondary; Protein Structure, Tertiary; Tyrosine | 2012 |
Identification of nitration sites by peroxynitrite on p16 protein.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cyclin-Dependent Kinase Inhibitor p16; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Sequence Data; Nitrates; Peroxynitrous Acid; Recombinant Proteins; Sequence Analysis, Protein; Tandem Mass Spectrometry; Tyrosine | 2012 |
Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers.
Topics: Adenosine; Alanine Transaminase; Allopurinol; Amidines; Animals; Benzylamines; Bilirubin; Caspase 3; Ethanol; Fatty Liver; Female; Gene Expression; Glutathione; Graft Survival; Insulin; JNK Mitogen-Activated Protein Kinases; Liver Transplantation; Membrane Potential, Mitochondrial; Mitochondria; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Organ Preservation Solutions; Raffinose; Rats; Rats, Inbred Lew; Reactive Nitrogen Species; Tyrosine | 2012 |
Morphological, immunohistochemical and biochemical effects of non-pulsatile ex vivo perfusion with crescent pressures in human saphenous veins.
Topics: Aged; Female; Humans; Immunohistochemistry; In Vitro Techniques; Male; Malondialdehyde; Microscopy, Electron, Transmission; Middle Aged; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Perfusion; Pressure; Saphenous Vein; Stress, Mechanical; Tyrosine | 2015 |
Nitrotyrosine and nitrate/nitrite levels in cardiac arrest survivors treated with endovascular hypothermia.
Topics: Female; Heart Arrest; Humans; Hypothermia; Hypothermia, Induced; Male; Middle Aged; Nitrates; Nitrites; Oxidative Stress; Tyrosine | 2012 |
Amyloid beta modulated the selectivity of heme-catalyzed protein tyrosine nitration: an alternative mechanism for selective protein nitration.
Topics: Amyloid beta-Peptides; Binding Sites; Blotting, Western; Circular Dichroism; Glyceraldehyde-3-Phosphate Dehydrogenases; Hemeproteins; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Models, Molecular; Nitrates; Phosphopyruvate Hydratase; Substrate Specificity; Tyrosine | 2012 |
The dose-dependent immunoregulatory effects of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester in rats with sub-acute peritonitis.
Topics: Acute Disease; Animals; Arginine; Body Weight; Cell Proliferation; Cytokines; Dose-Response Relationship, Drug; Humans; Immunomodulation; Infusions, Parenteral; Leukocyte Count; Leukocytes; Male; Nitrates; Nitric Oxide Synthase; Nitrites; Organ Size; Parenteral Nutrition; Peritonitis; Rats; Rats, Wistar; Spleen; Tyrosine | 2012 |
Iron increases liver injury through oxidative/nitrative stress in diabetic rats: Involvement of nitrotyrosination of glucokinase.
Topics: Animals; Blotting, Western; Body Weight; Diabetes Mellitus, Type 2; Glucokinase; Iron; Iron Overload; Liver; Liver Function Tests; Male; Nitrates; Nitric Oxide; Nitrites; Organ Size; Oxidation-Reduction; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Streptozocin; Tandem Mass Spectrometry; Tyrosine | 2012 |
Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin.
Topics: Analysis of Variance; Antioxidants; Cell Line; Endothelial Cells; Glucose; Histocytochemistry; Humans; Intracellular Signaling Peptides and Proteins; Ischemia; Kelch-Like ECH-Associated Protein 1; Melatonin; Microscopy, Fluorescence; NF-E2-Related Factor 2; Nitrates; Oxygen; Stress, Physiological; Tyrosine | 2013 |
Characterization of nitrotyrosine as a biomarker for arthritis and joint injury.
Topics: Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Arthritis, Rheumatoid; Case-Control Studies; Chemokines; Chondrocalcinosis; Cytokines; Female; Humans; Male; Matrix Metalloproteinases, Secreted; Menisci, Tibial; Nitrates; Osteoarthritis, Knee; Synovial Fluid; Tibial Meniscus Injuries; Tyrosine | 2013 |
INF-β1b therapy modulates L-arginine and nitric oxide metabolism in patients with relapse remittent multiple sclerosis.
Topics: Adult; Arginase; Arginine; Biomarkers; Drug Monitoring; Female; Follow-Up Studies; Humans; Inflammation; Interferon beta-1b; Interferon-beta; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nitrates; Nitric Oxide; Nitrites; Nitroso Compounds; Severity of Illness Index; Sulfhydryl Compounds; Tyrosine; Young Adult | 2012 |
The importance of L-arginine metabolism modulation in diabetic patients with distal symmetric polyneuropathy.
Topics: Aged; Arginase; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electrodiagnosis; Female; Fructosamine; Glycated Hemoglobin; Humans; Male; Methylation; Middle Aged; Nitrates; Nitrites; S-Nitrosothiols; Tyrosine | 2013 |
Phosphorylation and nitration of tyrosine residues affect functional properties of Synaptophysin and Dynamin I, two proteins involved in exo-endocytosis of synaptic vesicles.
Topics: Amino Acid Sequence; Animals; Dynamin I; Endocytosis; Exocytosis; In Vitro Techniques; Molecular Sequence Data; Nitrates; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Rats; Sequence Homology, Amino Acid; Structure-Activity Relationship; Synaptic Vesicles; Synaptophysin; Tyrosine | 2013 |
Periodontal disease, periodontal treatment and systemic nitric oxide in dogs.
Topics: Animals; Dog Diseases; Dogs; Female; Hemoglobins; Male; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Periodontal Diseases; Time Factors; Tyrosine | 2013 |
Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury.
Topics: Animals; Biomarkers; Cyclic GMP; Enzyme Inhibitors; Immunohistochemistry; Infusions, Parenteral; Kidney; Lysine; Male; Nephrectomy; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury; Rutin; Tyrosine | 2013 |
A preclinical study on the protective effect of melatonin against methotrexate-induced small intestinal damage: effect mediated by attenuation of nitrosative stress, protein tyrosine nitration, and PARP activation.
Topics: Animals; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Enterocolitis; Intestinal Mucosa; Intestine, Small; Male; Melatonin; Methotrexate; Nitrates; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine | 2013 |
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling.
Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Tyrosine | 2013 |
The effect of high-dose insulin analog initiation therapy on lipid peroxidation products and oxidative stress markers in type 2 diabetic patients.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dinoprost; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Insulin; Lipid Peroxidation; Male; Metformin; Middle Aged; Nitrates; Nitrites; Oxidative Stress; Protein Carbonylation; Sulfonylurea Compounds; Tyrosine | 2013 |
Up-regulation of protein tyrosine nitration in methamphetamine-induced neurotoxicity through DDAH/ADMA/NOS pathway.
Topics: Amidohydrolases; Animals; Arginine; Base Sequence; Brain; DNA Primers; Male; Methamphetamine; Nitrates; Nitric Oxide Synthase; PC12 Cells; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine; Up-Regulation | 2013 |
From treatment to diagnosis of Kounis syndrome in the catherization laboratory: the resolution of vasospastic angina after intracoronary tirofiban and nitrate therapy.
Topics: Acute Coronary Syndrome; Cardiac Catheterization; Coronary Vasospasm; Coronary Vessels; Humans; Hypersensitivity; Male; Middle Aged; Nitrates; Syndrome; Tirofiban; Tyrosine | 2013 |
Peroxynitrite induced structural changes result in the generation of neo-epitopes on human serum albumin.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Epitopes; Female; Humans; Immunoglobulin G; Injections, Intramuscular; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Protein Carbonylation; Protein Conformation; Rabbits; Serum Albumin; Spectroscopy, Fourier Transform Infrared; Tyrosine | 2013 |
Antioxidant promotion of tyrosine nitration in the presence of copper(II).
Topics: Antioxidants; Copper; Hydrogen Peroxide; Mass Spectrometry; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Reactive Nitrogen Species; Tyrosine | 2013 |
The potentiation of myeloperoxidase activity by the glycosaminoglycan-dependent binding of myeloperoxidase to proteins of the extracellular matrix.
Topics: Cells, Cultured; Collagen Type IV; Dimerization; Endothelium, Vascular; Extracellular Matrix Proteins; Fibronectins; Glycosaminoglycans; Humans; Nitrates; Oxidative Stress; Peroxidase; Protein Binding; Tyrosine | 2013 |
Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats.
Topics: Aldehydes; Animals; Arterioles; Behavior, Animal; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glycation End Products, Advanced; Guanidines; Male; Nerve Fibers; Nitrates; Pain Measurement; Pyruvaldehyde; Rats; Rats, Wistar; Reduced Folate Carrier Protein; Sciatic Nerve; Skin; Sulfones; Superoxides; Tyrosine | 2013 |
Heme binding induces dimerization and nitration of truncated β-amyloid peptide Aβ16 under oxidative stress.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Dimerization; Hemin; Humans; Kinetics; Nitrates; Oxidation-Reduction; Peptide Fragments; Tyrosine | 2013 |
Characterization of a cellular denitrase activity that reverses nitration of cyclooxygenase.
Topics: Adaptation, Physiological; Animals; Cell Line; Cells, Cultured; Cyclooxygenase 1; Endothelium, Vascular; Humans; Macrophages; Mice; Mice, Inbred C57BL; Models, Animal; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Oxidoreductases; Rats; Tyrosine | 2013 |
Inhibition of peroxisomal hydroxypyruvate reductase (HPR1) by tyrosine nitration.
Topics: Amino Acid Sequence; Arabidopsis; Evolution, Molecular; Glutathione; Hydrogen Peroxide; Hydroxypyruvate Reductase; Models, Molecular; Molecular Sequence Data; Nitrates; Oxidation-Reduction; Peroxisomes; Peroxynitrous Acid; Pisum sativum; Plant Leaves; Proteome; Tyrosine | 2013 |
Heterogeneity in metal binding by individual fluorescent components in a eutrophic algae-rich lake.
Topics: Biomass; China; Coordination Complexes; Copper; Cyanobacteria; Eutrophication; Factor Analysis, Statistical; Fluorescence; Humic Substances; Iron; Lakes; Nitrates; Polymers; Proteins; Spectrometry, Fluorescence; Tryptophan; Tyrosine | 2013 |
Tyrosine residues play an important role in heme detoxification by serum albumin.
Topics: Heme; Humans; Nitrates; Peroxidases; Protein Carbonylation; Serum Albumin; Tyrosine | 2014 |
Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-α: the role of PKC-β2 and NADPH oxidase.
Topics: Apoptosis; Cell Survival; Cytoprotection; Flow Cytometry; Human Umbilical Vein Endothelial Cells; Humans; L-Lactate Dehydrogenase; Malondialdehyde; NADPH Oxidases; Nitrates; Nitrites; Nitroglycerin; Phthalimides; Propofol; Protein Kinase C beta; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Identification of nitrated tyrosine residues of protein kinase G-Iα by mass spectrometry.
Topics: Animals; Baculoviridae; Cyclic GMP-Dependent Protein Kinase Type I; Gene Expression; Humans; Kinetics; Mutation; Nitrates; Nitric Oxide; Peptide Fragments; Peroxynitrous Acid; Phenylalanine; Recombinant Proteins; Sf9 Cells; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spodoptera; Tandem Mass Spectrometry; Trypsin; Tyrosine | 2014 |
Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c.
Topics: Computer Simulation; Cytochromes c; Hydrogen-Ion Concentration; Ligands; Models, Molecular; Nitrates; Oxidation-Reduction; Protons; Thermodynamics; Tyrosine | 2014 |
Identification of nitrated immunoglobulin variable regions in the HIV-infected human brain: implications in HIV infection and immune response.
Topics: Amino Acid Sequence; Antibodies; Brain; Brain Chemistry; Encephalitis, Viral; HIV Infections; HIV-1; Humans; Immunity, Innate; Immunoglobulin Variable Region; Models, Molecular; Molecular Sequence Data; Nitrates; Tyrosine | 2014 |
Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolec
Topics: Animals; Binding Sites; Blotting, Western; Catalytic Domain; Chagas Disease; Crystallography, X-Ray; Cysteine; Electron Spin Resonance Spectroscopy; Electron Transport; Enzyme Activation; Host-Parasite Interactions; Isoenzymes; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nitrates; Peroxynitrous Acid; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Reactive Oxygen Species; Superoxide Dismutase; Trypanosoma cruzi; Tyrosine | 2014 |
Alleviation of plasma homocysteine level by phytoestrogen α-zearalanol might be related to the reduction of cystathionine β-synthase nitration.
Topics: Animals; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Female; Homocysteine; Hyperhomocysteinemia; Liver; Nitrates; Oxidation-Reduction; Phytoestrogens; Rats; Rats, Wistar; Treatment Outcome; Tyrosine; Zeranol | 2014 |
Protection against peroxynitrite reactions by flavonoids.
Topics: Antioxidants; Flavonoids; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2014 |
The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Blood Platelets; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Humans; Hypotension; Isosorbide Dinitrate; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Rats; Thrombin; Tyrosine; Vasodilator Agents | 2014 |
Analysis of nitrated proteins in Saccharomyces cerevisiae involved in mating signal transduction.
Topics: Amino Acid Sequence; Models, Molecular; Molecular Sequence Data; Nitrates; Protein Interaction Maps; Protein Processing, Post-Translational; Proteomics; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Tandem Mass Spectrometry; Tyrosine | 2015 |
Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cognition; Dopamine; Enzyme Inhibitors; Hepatic Encephalopathy; Immunoblotting; Immunohistochemistry; Injections, Intraventricular; Liver; Maze Learning; NADPH Oxidases; Nitrates; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Phosphorylation; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine | 2014 |
Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
Topics: Aging; Animals; Arginase; Cell Hypoxia; Enzyme Activation; Hypertension; Lung; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Pulmonary Artery; Rats, Sprague-Dawley; Tyrosine | 2015 |
Protein tyrosine nitration: a signaling mechanism conserved from yeast to man.
Topics: Nitrates; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tyrosine | 2015 |
Leghemoglobin is nitrated in functional legume nodules in a tyrosine residue within the heme cavity by a nitrite/peroxide-dependent mechanism.
Topics: Glycine max; Heme; Hydrogen Peroxide; Leghemoglobin; Nitrates; Nitric Oxide; Nitrites; Nitrogen Dioxide; Oxidative Stress; Peroxynitrous Acid; Phaseolus; Protein Processing, Post-Translational; Tyrosine | 2015 |
Label-free in-situ monitoring of protein tyrosine nitration in blood by surface-enhanced Raman spectroscopy.
Topics: Blood Proteins; Humans; Materials Testing; Metal Nanoparticles; Nitrates; Silver; Staining and Labeling; Surface Plasmon Resonance; Tyrosine | 2015 |
Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved?
Topics: Administration, Intravenous; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Hemodynamics; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide; Nitrites; Protein Processing, Post-Translational; Sodium Nitrite; Superoxides; Tyrosine | 2015 |
Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Apoptosis; Cell Nucleus; Chymases; Cytokines; Disease Models, Animal; Disease Progression; Drug Interactions; Ethanolamines; Gene Expression Regulation; Kidney; Male; Mice; Nitrates; Nitrites; Oxidative Stress; Palmitic Acids; Reperfusion Injury; Risk Factors; Silymarin; Transcription Factor RelA; Tyrosine | 2015 |
Role of thioredoxin nitration in bleomycin-induced pulmonary fibrosis in rats.
Topics: Animals; Bleomycin; Disease Models, Animal; Humans; Hydroxyproline; Idiopathic Pulmonary Fibrosis; Lung; Male; Nitrates; Oxidation-Reduction; Pulmonary Fibrosis; Rats; Rats, Wistar; Thioredoxins; Tyrosine | 2016 |
An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability.
Topics: Animals; Blotting, Western; Brain; Cytosol; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Intellectual Disability; Isoenzymes; Lipopolysaccharides; Mice, Knockout; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tissue Culture Techniques; Transcription Factor RelA; Tyrosine | 2016 |
Protein-bound tyrosine oxidation, nitration and chlorination by-products assessed by ultraperformance liquid chromatography coupled to tandem mass spectrometry.
Topics: Animals; Animals, Newborn; Chromatography, Liquid; Halogenation; Nitrates; Oxidation-Reduction; Proteins; Swine; Tandem Mass Spectrometry; Tyrosine | 2016 |
Role of Oxygen Free Radicals, Nitric Oxide and Mitochondria in Mediating Cardiac Alterations During Liver Cirrhosis Induced by Thioacetamide.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Heart Diseases; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Mitochondria, Heart; Mitochondrial Swelling; Myocytes, Cardiac; Nitrates; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Thioacetamide; Time Factors; Tyrosine | 2017 |
Mechanism of the Reaction of Human Manganese Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine 34.
Topics: Blotting, Western; Catalytic Domain; Humans; Kinetics; Models, Molecular; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Proteomics; Superoxide Dismutase; Tyrosine; Umbelliferones | 2016 |
Analysis of Chlorination, Nitration, and Nitrosylation of Tyrosine and Oxidation of Methionine and Cysteine in Hemoglobin from Type 2 Diabetes Mellitus Patients by Nanoflow Liquid Chromatography Tandem Mass Spectrometry.
Topics: Adult; Aged; Amino Acid Sequence; Cysteine; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Halogenation; Hemoglobins; Humans; Male; Methionine; Middle Aged; Nitrates; Nitroso Compounds; Oxidation-Reduction; Tyrosine | 2016 |
Mitigation of a nitrate reducing Pseudomonas aeruginosa biofilm and anaerobic biocorrosion using ciprofloxacin enhanced by D-tyrosine.
Topics: Anaerobiosis; Biofilms; Ciprofloxacin; Corrosion; Drug Synergism; Microbial Sensitivity Tests; Nitrates; Pseudomonas aeruginosa; Tyrosine | 2017 |
Hemin-Graphene Derivatives with Increased Peroxidase Activities Restrain Protein Tyrosine Nitration.
Topics: Animals; Biocompatible Materials; Catalysis; Cattle; Chromatography, High Pressure Liquid; Free Radicals; Graphite; Hemin; Hydrogen Peroxide; Microscopy, Atomic Force; Nitrates; Nitrites; Oxidation-Reduction; Peroxidase; Serum Albumin, Bovine; Spectroscopy, Fourier Transform Infrared; Tyrosine | 2017 |
5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride (FeTPPS), a peroxynitrite decomposition catalyst, catalyzes protein tyrosine nitration in the presence of hydrogen peroxide and nitrite.
Topics: Animals; Arginine; Catalysis; Cattle; Chromatography, Liquid; Food Preservation; Hep G2 Cells; Humans; Hydrogen Peroxide; Nitrates; Nitrites; Serum Albumin, Bovine; Sodium Nitrite; Tandem Mass Spectrometry; Tyrosine | 2018 |
Acute alterations in the hematological and hemorheological profile induced by resistance training and possible implication for microvascular functionality.
Topics: Adaptation, Physiological; Adult; Biomarkers; Blood Glucose; Erythrocytes; Hemorheology; Humans; Lipid Peroxidation; Male; Malondialdehyde; Microcirculation; Microvessels; Muscle Contraction; Nitrates; Oxidative Stress; Quadriceps Muscle; Resistance Training; Time Factors; Tyrosine; Young Adult | 2018 |
Inhibition of Fatty Acid Amide Hydrolase by PF-3845 Alleviates the Nitrergic and Proinflammatory Response in Rat Hippocampus Following Acute Stress.
Topics: Amidohydrolases; Animals; Corticosterone; Cytokines; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Hippocampus; Inflammation Mediators; Male; Nitrates; Nitric Oxide; Nitrites; Nitrosative Stress; Piperidines; Pyridines; Rats, Wistar; Restraint, Physical; Signal Transduction; Stress, Psychological; Time Factors; Tyrosine | 2018 |
Prediction of Nitrated Tyrosine Residues in Protein Sequences by Extreme Learning Machine and Feature Selection Methods.
Topics: Amino Acid Sequence; Computational Biology; Databases, Protein; Machine Learning; Nitrates; Protein Processing, Post-Translational; Tyrosine | 2018 |
Copper Binding Induces Nitration of NPY under Nitrative Stress: Complicating the Role of NPY in Alzheimer's Disease.
Topics: Alzheimer Disease; Chromatography, Liquid; Copper; Electrochemical Techniques; Humans; Neuropeptide Y; Nitrates; Nitrosative Stress; Oxidative Stress; Protein Binding; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tyrosine | 2018 |
[Research on the Reaction Dynamics between Peroxynitrite and Tyrosine Catalyzed with Mimic Enzyme through Flow Injection Analyzer].
Topics: Catalysis; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2016 |
Sevoflurane preconditioning induces tolerance to brain ischemia partially via inhibiting thioredoxin-1 nitration.
Topics: Administration, Inhalation; Animals; Brain Ischemia; Humans; Ischemic Preconditioning; Male; Nitrates; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Sevoflurane; Thioredoxins; Tyrosine | 2018 |
Dewetting Controls Plant Hormone Perception and Initiation of Drought Resistance Signaling.
Topics: Abscisic Acid; Adaptation, Physiological; Arabidopsis; Arabidopsis Proteins; Binding Sites; Droughts; Gene Expression Regulation, Plant; Intracellular Signaling Peptides and Proteins; Molecular Dynamics Simulation; Nitrates; Plant Growth Regulators; Plant Stomata; Plant Transpiration; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Receptors, Cell Surface; Signal Transduction; Stress, Physiological; Tyrosine; Water | 2019 |
The alkaline transition of cytochrome c revisited: Effects of electrostatic interactions and tyrosine nitration on the reaction dynamics.
Topics: Alkalies; Animals; Cytochromes c; Horses; Hydrogen-Ion Concentration; Ligands; Molecular Dynamics Simulation; Nitrates; Oxidation-Reduction; Static Electricity; Tyrosine | 2019 |
Genetically Encoded Protein Tyrosine Nitration in Mammalian Cells.
Topics: 14-3-3 Proteins; Amino Acyl-tRNA Synthetases; Animals; HEK293 Cells; Humans; Methanosarcina barkeri; Nitrates; Oxidative Stress; Proteins; Superoxide Dismutase; Tyrosine | 2019 |
Maternal undernutrition aggravates renal tubular necrosis and interstitial fibrosis after unilateral ureteral obstruction in male rat offspring.
Topics: Animals; Disease Models, Animal; Female; Fibrosis; Kidney; Kidney Tubular Necrosis, Acute; Male; Malnutrition; Maternal-Fetal Exchange; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Tyrosine; Ureteral Obstruction | 2019 |
Identification of Human IDO1 Enzyme Activity by Using Genetically Encoded Nitrotyrosine.
Topics: Amino Acid Sequence; Binding Sites; Biocatalysis; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Models, Molecular; Nitrates; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Tryptophan; Tyrosine | 2020 |
Mechanism of Fully Reversible, pH-Sensitive Inhibition of Human Glutamine Synthetase by Tyrosine Nitration.
Topics: Adenosine Triphosphate; Binding Sites; Glutamate-Ammonia Ligase; Humans; Hydrogen-Ion Concentration; Kinetics; Molecular Dynamics Simulation; Nitrates; Recombinant Proteins; Thermodynamics; Tyrosine | 2020 |
rPTMDetermine: A Fully Automated Methodology for Endogenous Tyrosine Nitration Validation, Site-Localization, and Beyond.
Topics: Amino Acid Sequence; Automation; Discriminant Analysis; Nitrates; Peptides; Protein Processing, Post-Translational; Supervised Machine Learning; Tyrosine | 2020 |
Unravelling the different causes of nitrate and ammonium effects on coral bleaching.
Topics: Ammonium Compounds; Analysis of Variance; Animals; Anthozoa; Antioxidants; Calcification, Physiologic; Chlorophyll; Energy Metabolism; Lactic Acid; Lipid Peroxidation; Models, Biological; Nitrates; Nitric Oxide; Nitrosation; Oxidative Stress; Photosynthesis; Reactive Oxygen Species; Symbiosis; Tyrosine | 2020 |
Inhalation of ammonium sulfate and ammonium nitrate adversely affect sperm function.
Topics: Administration, Inhalation; Air Pollutants; Ammonium Sulfate; Animals; Cyclic AMP-Dependent Protein Kinases; Male; Mice, Inbred C57BL; Nitrates; Phosphorylation; Sperm Capacitation; Sperm Motility; Spermatozoa; Tyrosine | 2020 |
Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS.
Topics: Brain Ischemia; Chromatography, Liquid; Fibrinogen; Hemostatics; Humans; Ischemic Stroke; Nitrates; Stroke; Tandem Mass Spectrometry; Tyrosine | 2021 |
The oxidative reactivity of three manganese(III) porphyrin complexes with hydrogen peroxide and nitrite toward catalytic nitration of protein tyrosine.
Topics: Animals; Cattle; Hydrogen Peroxide; Hydrogen-Ion Concentration; Metalloporphyrins; Nitrates; Nitrites; Oxidative Stress; Serum Albumin, Bovine; Tyrosine | 2021 |
Cardiolipin interactions with cytochrome c increase tyrosine nitration yields and site-specificity.
Topics: Animals; Binding Sites; Cardiolipins; Cytochromes c; Horses; Kinetics; Models, Molecular; Nitrates; Peroxynitrous Acid; Protein Conformation; Protein Processing, Post-Translational; Substrate Specificity; Tyrosine | 2021 |
Light-Controlled Tyrosine Nitration of Proteins.
Topics: alpha-Synuclein; Animals; Light; Mice; Nitrates; Oxidation-Reduction; Tumor Necrosis Factor-alpha; Tyrosine | 2021 |
Site-specific identification and validation of hepatic histone nitration in vivo: Implications for alcohol-induced liver injury.
Topics: Amino Acid Sequence; Animals; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Ethanol; Histones; Liver; Male; Mice; Mice, Inbred C57BL; Molecular Dynamics Simulation; Nitrates; Oxidative Stress; Tandem Mass Spectrometry; Tyrosine | 2021 |
Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation.
Topics: Humans; Nitrates; Proteins; Tyrosine | 2023 |
Structural and spectroscopic characterization of RufO indicates a new biological role in rufomycin biosynthesis.
Topics: Actinobacteria; Amino Acids; Cytochrome P-450 Enzyme System; Heme; Molecular Docking Simulation; Nitrates; Oligopeptides; Tyrosine | 2023 |
Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO.
Topics: Cytochrome P-450 Enzyme System; Molecular Dynamics Simulation; Nitrates; Substrate Specificity; Tyrosine | 2023 |
Photochemically-induced protein tyrosine nitration in vitro and in cellula by 5-methyl-1,4-dinitro-1H-imidazole (DNI): synthesis and biochemical characterization.
Topics: Animals; Cattle; Endothelial Cells; Imidazoles; Nitrates; Nitrogen Dioxide; Tyrosine | 2023 |