nitrates and sapropterin

nitrates has been researched along with sapropterin in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.17)	18.7374
1990's	14 (30.43)	18.2507
2000's	23 (50.00)	29.6817
2010's	8 (17.39)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G	1
Marletta, MA; Tayeh, MA	1
Bachus, KE; Dittman, WA; Mason, SN; McDonald, B; Misukonis, MA; Sauls, DL; Shami, PJ; Smith, GK; Weinberg, JB; Wood, ER	1
Kim, YM; Lancaster, JR	1
Philippu, A; Prast, H; Wachter, H; Werner, ER; Werner-Felmayer, G	1
Block, ER; Patel, JM; Zhang, J	1
Blau, N; Linscheid, P; Schaffner, A; Schneemann, M; Schoedon, G; Walter, R	1
Garver, RI; Haddad, IY; Hong, J; Matalon, S; Sorscher, EJ; Tzeng, E	1
Akimoto, K; Hattori, Y; Kasai, K; Nakanishi, N	1
Bryan, TW; Jinkins, PA; Milligan, SA; Prado, SC; Robbins, RA	1
Gorren, AC; Mayer, B	1
Kato, Y; Koshimura, K; Murakami, Y; Tanaka, J	1
Mayer, B; Schmidt, K; Werner, ER; Werner-felmayer, G	1
Brand, MP; Canevari, L; Clark, JB; Heales, SJ; Hyland, K; Land, JM	1
Katusic, Z; Milstien, S	1
Crawley, J; Dobbie, M; Marsh, K; Surtees, R; Waruiru, C	1
Freeman, BA; Fukai, T; Harrison, DG; Kurz, S; Laursen, JB; McCann, L; Somers, M; Tarpey, M; Warnholtz, A	1
Galley, HF; Grant, IS; Le Cras, AE; Webster, NR; Yassen, K	1
Cheng, TH; Hong, HJ; Hsiao, G; Yen, MH	1
Lüscher, TF; Noll, G; Spieker, LE	1
Blau, N; Thöny, B; Zorzi, G	1
Billiar, TR; Ha, KS; Hatakeyama, K; Kim, CK; Kim, PK; Kim, YM; Kwon, YG; Lee, KS; Lee, SJ; Na, HJ; Park, JH; Yoneyama, T	1
Fujii, S; Igarashi, J; Kosaka, H; Yamamoto, A; Yoneyama, H; Zhang, L	1
Ghosh, S; Mukherjee, S; Regulski, M; Sahoo, R; Sengupta, R; Stuehr, DJ; Tully, T	1
Benchetrit, S; Bernheim, J; Podjarny, E; Pomeranz, A; Rashid, G; Rathaus, M; Shapira, J	1
Bassenge, E; Schwemmer, M	1
Edmondson, DE; Hurshman, AR; Krebs, C; Marletta, MA	1
Archer, SL; Chrapko, WE; Jurasz, P; Lara, N; Le Mellédo, JM; Radomski, MW	1
Hashikabe, Y; Hattori, Y; Kase, H; Nakanishi, N; Uchida, K	1
Kajiya, F; Kashihara, N; Kimoto, M; Miyasaka, T; Mochizuki, S; Ogasawara, Y; Ono, J; Yada, T	1
Hiroi, T; Ishii, M; Kiuchi, Y; Shimizu, S; Wajima, T	1
Brandacher, G; Maglione, M; Margreiter, R; Obrist, P; Schneeberger, S; Thoeni, G; Werner, ER; Werner-Felmayer, G; Wrulich, OA	1
Banba, N; Hattori, Y; Iwata, C; Kamikawa, Y; Kasai, K; Monden, T; Satoh, H; Uchida, K; Wang, X	1
Heales, SJ; Hyland, K; Lam, AA	1
Druhan, LJ; Sun, J; Zweier, JL	1
Emoto, N; Fukatsu, A; Hayashi, T; Hirata, K; Ikemoto, K; Kawashima, S; Nomura, T; Sasaki, N; Shinohara, M; Shiraki, R; Takaya, T; Takeda, M; Yamashita, T; Yokoyama, M	1
Hamadate, N; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M	1
Song, P; Wang, S; Wu, Y; Xu, J; Zou, MH	1
Hamadate, N; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M; Tsutsui, M	1
Chappell, MC; Chen, AF; Gallagher, PE; Lindsey, SH; Varagic, J; Yamaleyeva, LM; Zhang, LL	1
Cui, J; Cun, Y; Dai, Y; Shi, A	1
Fung, HL; Mohan, S	1
Imanishi, M; Kitabayashi, C; Konishi, Y; Maeda, I; Masada, M; Morikawa, T; Nishiyama, A; Okada, N; Shirahashi, N; Wilcox, CS	1
Messina, LM; Tie, G; Yan, J	1
Abad, E; Garcia-Dorado, D; Hernando, V; Inserte, J; Poncelas-Nozal, M; Vilardosa, Ú	1
Bayatli, N; Gur, S; Kaya, E; Un, O; Yilmaz, D	1

Reviews

3 review(s) available for nitrates and sapropterin

Article	Year
The versatile and complex enzymology of nitric oxide synthase. Biochemistry. Biokhimiia, 1998, Volume: 63, Issue:7 Topics: Animals; Biopterins; Calcium; Dimerization; Humans; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Conformation	1998
Current strategies and perspectives for correcting endothelial dysfunction in atherosclerosis. Journal of cardiovascular pharmacology, 2001, Volume: 38 Suppl 2 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aspirin; Biopterins; Calcium Channel Blockers; Coronary Artery Disease; Endothelins; Endothelium, Vascular; Folic Acid; Hormone Replacement Therapy; Humans; Nitrates; Nitric Oxide; Nitric Oxide Synthase	2001
New approaches to overcome tolerance to nitrates. Cardiovascular drugs and therapy, 2003, Volume: 17, Issue:2 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Biopterins; Diet; Drug Tolerance; Folic Acid; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitrates; Nitric Oxide Donors; Oxidative Stress; Vasodilator Agents	2003

Trials

2 trial(s) available for nitrates and sapropterin

Article	Year
Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder. Biological psychiatry, 2004, Jul-15, Volume: 56, Issue:2 Topics: Adolescent; Adult; Anxiety Disorders; Biopterins; Blood Platelets; Depressive Disorder, Major; Female; Humans; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Reference Values	2004
Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1 Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressure; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Hemodynamics; Humans; Kidney; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Valine; Valsartan	2013

Article

Year

Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder.

Biological psychiatry, 2004, Jul-15, Volume: 56, Issue:2

Topics: Adolescent; Adult; Anxiety Disorders; Biopterins; Blood Platelets; Depressive Disorder, Major; Female; Humans; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Reference Values

2004

Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.

Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1

Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressure; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Hemodynamics; Humans; Kidney; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Valine; Valsartan

2013

Other Studies

41 other study(ies) available for nitrates and sapropterin

Article	Year
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. The Journal of experimental medicine, 1990, Dec-01, Volume: 172, Issue:6 Topics: Animals; Biopterins; Cells, Cultured; Cytokines; Fibroblasts; Interferon-gamma; Interleukin-1; Kinetics; Methotrexate; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Pteridines; Pterins; Recombinant Proteins; Skin; Sugar Acids; Tumor Necrosis Factor-alpha	1990
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. The Journal of biological chemistry, 1989, Nov-25, Volume: 264, Issue:33 Topics: Animals; Arginine; Biopterins; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Kinetics; Macrophages; NADP; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction	1989
Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. Blood, 1995, Aug-01, Volume: 86, Issue:3 Topics: Amino Acid Oxidoreductases; Animals; Base Sequence; Biopterins; Cell Line; DNA Primers; Enzyme Induction; Gene Expression; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Monocytes; Nitrates; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; RNA, Messenger	1995
Tetrahydrobiopterin-dependent nitrite oxidation to nitrate in isolated rat hepatocytes. FEBS letters, 1993, Oct-18, Volume: 332, Issue:3 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Cytosol; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tumor Necrosis Factor-alpha	1993
Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat. FEBS letters, 1993, May-17, Volume: 322, Issue:3 Topics: Animals; Biopterins; Blood Pressure; Enzyme Induction; GTP Cyclohydrolase; Lipopolysaccharides; Male; Nitrates; Organ Specificity; Rats; Rats, Sprague-Dawley	1993
Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity. American journal of respiratory cell and molecular biology, 1996, Volume: 15, Issue:3 Topics: Allosteric Regulation; Animals; Antioxidants; Bacterial Proteins; Biopterins; Carcinogens; Cells, Cultured; Endothelium, Vascular; Ferricyanides; Glutaredoxins; Lung; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Oxidoreductases; Oxyhemoglobins; Protein Processing, Post-Translational; Proteins; Pulmonary Artery; RNA, Messenger; Sodium Nitrite; Sulfhydryl Compounds; Superoxide Dismutase; Swine; Thioredoxins	1996
Nitrite generation in interleukin-4-treated human macrophage cultures does not involve the nitric oxide synthase pathway. The Journal of infectious diseases, 1997, Volume: 175, Issue:1 Topics: Amino Acids; Animals; Arginine; Biopterins; Cells, Cultured; Culture Media; Female; Humans; Interferon-gamma; Interleukin-4; Macrophages; Male; Muscle, Smooth, Vascular; Neopterin; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Rats; Recombinant Proteins	1997
Modulation of adenovirus-mediated gene transfer by nitric oxide. American journal of respiratory cell and molecular biology, 1997, Volume: 16, Issue:5 Topics: 3T3 Cells; Adenoviruses, Human; Animals; Antioxidants; beta-Galactosidase; Biopterins; Cell Survival; Cyclic GMP; Enzyme Inhibitors; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Humans; Luciferases; Lung; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Pteridines; Pterins; Transfection	1997
Glucocorticoid regulation of nitric oxide and tetrahydrobiopterin in a rat model of endotoxic shock. Biochemical and biophysical research communications, 1997, Nov-17, Volume: 240, Issue:2 Topics: Adrenalectomy; Animals; Biopterins; Dexamethasone; Disease Models, Animal; Enzyme Induction; Escherichia coli; Glucocorticoids; GTP Cyclohydrolase; Hypotension; Kinetics; Lipopolysaccharides; Lung; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; RNA, Messenger; Shock, Septic; Transcription, Genetic	1997
Methotrexate inhibition of inducible nitric oxide synthase in murine lung epithelial cells in vitro. American journal of respiratory cell and molecular biology, 1998, Volume: 18, Issue:6 Topics: Animals; Antineoplastic Agents; Antioxidants; Biopterins; Blotting, Western; Cells, Cultured; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Epithelial Cells; Lung; Methotrexate; Mice; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger	1998
Self-protection of PC12 cells by 6R-tetrahydrobiopterin from nitric oxide toxicity. Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5 Topics: Animals; Biopterins; GTP Cyclohydrolase; Hypoxanthine; Neoplasm Proteins; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Nitroprusside; Oxidation-Reduction; PC12 Cells; Rats; Sugar Acids; Superoxides; Xanthine Oxidase	1998
Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin. European journal of biochemistry, 1999, Volume: 259, Issue:1-2 Topics: Animals; Biopterins; Cytokines; Endothelium, Vascular; Enzyme Inhibitors; Fibroblasts; Humans; Mice; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Phenylalanine Hydroxylase; Swine; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1999
Cerebrospinal fluid nitrite plus nitrate correlates with tetrahydrobiopterin concentration. Journal of inherited metabolic disease, 1999, Volume: 22, Issue:3 Topics: Adolescent; Biopterins; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Nitrates; Nitrites	1999
Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function. Biochemical and biophysical research communications, 1999, Oct-05, Volume: 263, Issue:3 Topics: Antioxidants; Biopterins; Endothelium, Vascular; Kinetics; Nitrates; Nitric Oxide Synthase; Oxidants; Oxidation-Reduction; Pteridines	1999
Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism? The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:2 Topics: Antimalarials; Biopterins; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Endothelium; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyindoleacetic Acid; Infant; Kenya; Malaria, Cerebral; Microglia; Neopterin; Nitrates; Nitrites; Quinolinic Acid; Tryptophan	2000
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation, 2001, Mar-06, Volume: 103, Issue:9 Topics: Acetylcholine; Animals; Aorta, Thoracic; Apolipoproteins E; Biopterins; Calcimycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Ionophores; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroglycerin; Pteridines; Pterins; Superoxides; Vasodilation; Vasodilator Agents	2001
Circulating tetrahydrobiopterin concentrations in patients with septic shock. British journal of anaesthesia, 2001, Volume: 86, Issue:4 Topics: APACHE; Biomarkers; Biopterins; Chromatography, High Pressure Liquid; Humans; Nitrates; Renal Insufficiency; Shock, Septic	2001
Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5 Topics: Acetylcholine; Animals; Antioxidants; Aorta; Biopterins; Blood Pressure; Culture Techniques; Dietary Supplements; Endothelium, Vascular; Hypertension; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Vasodilation	2001
Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency. Journal of neurochemistry, 2002, Volume: 80, Issue:2 Topics: Adolescent; Adult; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Humans; Infant; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Phenylketonurias; Phosphorus-Oxygen Lyases	2002
Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization. The Journal of biological chemistry, 2002, Dec-06, Volume: 277, Issue:49 Topics: Animals; Biopterins; Blotting, Northern; Blotting, Western; Cells, Cultured; Cyclic GMP; Cytokines; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; GTP Cyclohydrolase; Hepatocytes; Humans; Male; Muscle, Smooth; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Penicillamine; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors; Transfection	2002
Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6 Topics: Animals; Arginine; Biopterins; Gene Expression Regulation; Kidney; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Receptors, LDL; Receptors, Oxidized LDL; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class E; Superoxide Dismutase; Time Factors	2003
Characterization of Drosophila nitric oxide synthase: a biochemical study. Biochemical and biophysical research communications, 2003, Jun-27, Volume: 306, Issue:2 Topics: Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Drosophila; Electrons; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Hydrogen Peroxide; Hydrolysis; NADP; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Open Reading Frames; Protein Structure, Tertiary; Spectrophotometry; Time Factors; Trypsin; Ultraviolet Rays; Urea	2003
Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy. Nephron. Physiology, 2003, Volume: 94, Issue:1 Topics: Animals; Arginine; Biopterins; Blood Pressure; Creatinine; Hypertension; Kidney; Male; Mesenteric Arteries; Nephrectomy; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Renal Insufficiency	2003
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. Biochemistry, 2003, Nov-18, Volume: 42, Issue:45 Topics: Amino Acids; Arginine; Binding Sites; Biopterins; Catalysis; Dithionite; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Freezing; Heme; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxyhemoglobins; Protein Structure, Tertiary; Pterins; Recombinant Proteins; Time Factors	2003
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. Journal of hypertension, 2005, Volume: 23, Issue:7 Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Time Factors; Tyrosine; Up-Regulation	2005
Systemic nitric oxide production rate during hemodialysis and its relationship with nitric oxide-related factors. Blood purification, 2005, Volume: 23, Issue:4 Topics: Arginine; Biopterins; Blood Pressure; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitrates; Nitric Oxide; Renal Dialysis	2005
Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Arginine; Biopterins; Cyclic GMP; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxy Acids; Male; Malondialdehyde; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Potassium Channels; Rats; Rats, Sprague-Dawley	2006
Tetrahydrobiopterin compounds prolong allograft survival independently of their effect on nitric oxide synthase activity. Transplantation, 2006, Feb-27, Volume: 81, Issue:4 Topics: Animals; Biopterins; Graft Survival; Heart Transplantation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase; Nitrites; Transplantation, Homologous	2006
Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats. European journal of pharmacology, 2007, Jan-19, Volume: 555, Issue:1 Topics: Adiponectin; Adipose Tissue; Animals; Aorta, Thoracic; Biopterins; Blood Pressure; Endothelium, Vascular; Fructose; Male; Metabolic Syndrome; Myocardium; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides; Vasodilation	2007
Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states. Journal of inherited metabolic disease, 2007, Volume: 30, Issue:2 Topics: Animals; Biological Availability; Biopterins; Brain; Carrier Proteins; Glutathione; GTP Cyclohydrolase; Kidney; Lipopolysaccharides; Liver; Metabolism, Inborn Errors; Mice; Mutation; Nitrates; Nitric Oxide; Nitrites; Osmolar Concentration; Polycomb Repressive Complex 1	2007
Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase. Archives of biochemistry and biophysics, 2008, Mar-15, Volume: 471, Issue:2 Topics: Biopterins; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Hydrogen Peroxide; Hydroxyl Radical; Kinetics; Nitrates; Nitric Oxide Synthase Type I; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxygen; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxides	2008
Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus. Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6 Topics: Animals; Aorta; Biopterins; Carotid Arteries; Cholesterol; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; GTP Cyclohydrolase; Lung; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Streptozocin; Superoxides	2008
Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats. Journal of pharmacological sciences, 2008, Volume: 107, Issue:1 Topics: Acetylcholine; Anesthesia, General; Animals; Aorta, Thoracic; Biopterins; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; GTP Cyclohydrolase; Hypoxanthines; Male; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroprusside; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents	2008
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:3 Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Pressure; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypertension; In Vitro Techniques; Leupeptins; Mice; Mice, Inbred C57BL; Nitrates; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Transfection; Tyrosine; Vasodilation	2009
Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats. European journal of pharmacology, 2010, Apr-10, Volume: 631, Issue:1-3 Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Biopterins; Dietary Supplements; Endothelium, Vascular; Hemodynamics; Hypertension; In Vitro Techniques; Infusions, Intravenous; Male; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2010
Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:6 Topics: Animals; Biopterins; Blood Pressure; Female; Gene Expression Regulation; Hypertension; Inflammation; Kidney; Kidney Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Ornithine; Oxidative Stress; Rats; Rats, Inbred Lew; Renin; RNA, Messenger; Sodium Chloride, Dietary	2012
Tetrahydrobiopterin ameliorates hepatic ischemia-reperfusion Injury by coupling with eNOS in mice. The Journal of surgical research, 2012, Volume: 176, Issue:2 Topics: Alanine Transaminase; Animals; Biopterins; Delayed Graft Function; Dinoprost; Liver; Liver Diseases; Liver Transplantation; Mice; Mice, Inbred Strains; Nitrates; Nitric Oxide Synthase Type III; Reperfusion Injury; Superoxides; Vitamin B 12	2012
Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine. International journal of molecular sciences, 2012, Volume: 13, Issue:6 Topics: Arginine; Biopterins; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Lysine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress	2012
Tetrahydrobiopterin, L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitric oxide that increases blood flow recovery after hindlimb ischemia in the rat. Molecular medicine (Cambridge, Mass.), 2012, Oct-24, Volume: 18 Topics: Administration, Oral; Animals; Arginine; Ascorbic Acid; Biopterins; Calcium; Drug Synergism; Hindlimb; Ischemia; Male; Models, Biological; Muscles; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Recovery of Function; Regional Blood Flow	2012
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling. Journal of the American Heart Association, 2013, Jan-02, Volume: 2, Issue:1 Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Tyrosine	2013
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats. The aging male : the official journal of the International Society for the Study of the Aging Male, 2014, Volume: 17, Issue:4 Topics: Aging; Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Erectile Dysfunction; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Penile Erection; Penis; Rats, Wistar; Sodium Nitrite	2014