nitrates has been researched along with molsidomine in 196 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (7.14) | 18.7374 |
| 1990's | 105 (53.57) | 18.2507 |
| 2000's | 70 (35.71) | 29.6817 |
| 2010's | 7 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Groszmann, RJ; Rodríguez-Pérez, F | 1 |
| Schmid, M; Yeates, RA | 1 |
| Dubach, P; Ratti, R | 1 |
| Feelisch, M; Noack, E | 1 |
| Henry, PJ; Horowitz, JD; Louis, WJ | 1 |
| Förster, S; Schröder, H; Schrör, K; Woditsch, I | 1 |
| Dirschinger, J; Rudolph, W | 2 |
| Kober, G; Schulz, W | 1 |
| Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B | 1 |
| Feelisch, M; Noack, E; Ostrowski, J | 1 |
| Nemirovskaia, MA; Vertkin, AL; Zharov, EI | 1 |
| Alpert, JS | 1 |
| Holzmann, S; Kukovetz, WR | 2 |
| Gerzer, R; Grewe, R; Karrenbrock, B; Loeschke, K | 1 |
| Holzmann, S; Kukovetz, WR; Romanin, C | 1 |
| Gerzer, R; Heim, JM; Karrenbrock, B; Siess, W | 1 |
| Bassenge, E; Stewart, DJ | 1 |
| Abramowicz, M; Berkenboom, G; Degré, S; Sobolski, J; Stoupel, E; Vandermoten, P | 1 |
| Dirschinger, J; Fleck, E; Rudolph, W | 1 |
| Bassenge, E; Busse, R | 1 |
| Bockaert, J; Culcasi, M; Gaven, F; Lafon-Cazal, M; Pietri, S | 1 |
| Duran, D; Horwitz, J; Ischiropoulos, H | 1 |
| Campbell, G; De Groote, MA; Fang, FC; Granger, D; Prince, R; Xu, Y | 1 |
| Darley-Usmar, V; Moore, KP; Morrow, J; Roberts, LJ | 2 |
| Ankarcrona, M; Bonfoco, E; Krainc, D; Lipton, SA; Nicotera, P | 1 |
| Inoue, S; Kawanishi, S | 1 |
| Denzer, D; Hecker, G; Wohlfeil, S | 1 |
| Beckman, JS; Brunelli, L; Crow, JP | 1 |
| Beckman, JS; Crow, JP; McCord, JM | 1 |
| Beckman, J; Crow, JP; Haddad, IY; Hu, P; Matalon, S; Ye, Y | 1 |
| Fehske, W; Honikel, HJ | 1 |
| Brüne, B; Mohr, S; Stamler, JS | 1 |
| Klatt, P; Mayer, B; Schmidt, K | 1 |
| Berkenboom, G; de Cannière, D; Staroukine, M; Unger, P; Vachiery, JL | 1 |
| Augusto, O; Gatti, RM; Radi, R | 1 |
| Bode-Böger, SM; Böger, RH; Frölich, JC; Gerecke, U | 1 |
| Schrör, K; Strobach, H; Weber, AA | 1 |
| Chen, HS; Choi, YB; Lei, SZ; Lipton, SA; Loscalzo, J; Pan, ZH; Singel, DJ; Stamler, JS; Sucher, NJ | 1 |
| Bouton, C; Drapier, JC; Raveau, M | 1 |
| Darley-Usmar, V; Knowles, RG; Lizasoain, I; Moncada, S; Moro, MA | 1 |
| Constantine-Paton, M; Rentería, RC | 1 |
| Dickens, BF; Komarov, AM; Mak, IT; Stafford, RE; Wagner, TL; Weglicki, WB | 1 |
| Elliott, SJ | 1 |
| Green, CJ; Hidalgo, A; Mohammed, S; Motterlini, R; Sammut, I; Shah, KA; Srai, K | 1 |
| Haddad, IY; Matalon, S; Zhu, S | 1 |
| Bassenge, E; Cereda, R; Fink, B | 1 |
| Boulanger, CM; Desta, B; Nakashima, M; Vanhoutte, PM | 1 |
| Balazy, M; Barton, A; Bednar, MM; Bingham, J; Booth, C; Fuller, SP; Golding, L; Gross, CE; Murphy, M | 1 |
| Ballmaier, D; Briviba, K; Epe, B; Roussyn, I; Sies, H | 1 |
| Darley-Usmar, VM; Diczfalusy, U; Dzeletovic, S; Patel, RP; Wilson, MT | 1 |
| Crews, BC; Landino, LM; Marnett, LJ; Morrow, JD; Timmons, MD | 1 |
| Bassenge, E; Dikalov, S; Skatchkov, M | 1 |
| Haussmann, HJ; Muller, T; Schepers, G | 1 |
| Hoglen, NC; Liebler, DC; Sipes, IG; Waller, SC | 1 |
| Hemmens, B; Leopold, E; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER | 1 |
| Fisher, D; Ischiropoulos, H; Kang, M; Thom, SR | 1 |
| Gewitz, MH; Gloster, ES; Mathew, R; Sundararajan, T; Thompson, CI; Zeballos, GA | 1 |
| Holm, P; Kankaanranta, H; Knowles, RG; Kosonen, O; Moilanen, E; Vuorinen, P | 1 |
| Ohshima, H; Yoshie, Y | 1 |
| Asahi, M; Fujii, J; Hori, M; Kuzuya, T; Shimonishi, Y; Takao, T; Taniguchi, N | 1 |
| Bouton, C; Drapier, JC; Hirling, H | 1 |
| Invernizzi, P; O'Connor, M; Salzman, AL; Setchell, KD; Szabó, C; Ueta, I | 1 |
| Schächinger, V; Zeiher, AM | 1 |
| Blasini, R; Lehmann, G; Schömig, A | 1 |
| Kondo, H; Niki, E; Takahashi, M | 1 |
| Ade, P; Balduzzi, M; Guastadisegni, C; Levi, G; Minghetti, L; Nicolini, A; Polazzi, E | 1 |
| Fink, MP; Menconi, MJ; Unno, N | 1 |
| Janssen, YM; Matalon, S; Mossman, BT | 1 |
| Anggård, EE; Carrier, MJ; Quine, LA | 1 |
| Amin, N; Pearce, B | 1 |
| Angaut-Petit, D; Blanchard, B; Ducrocq, C; Faille, L; Meunier, FA; Morot Gaudry-Talarmain, Y; Moulian, N | 1 |
| Gow, AJ; Ischiropoulos, H; Thom, SR | 1 |
| Cuthbertson, BH; Galley, HF; Webster, NR | 1 |
| Christopher, TA; Ischiropoulos, H; Liu, GL; Lopez, BL; Ma, XL | 1 |
| Denenberg, AG; Kennedy, M; Salzman, AL; Szabó, C | 1 |
| Brandi, ML; MacIntyre, I; Mancini, L; Moradi-Bidhendi, N | 1 |
| Arnal, JF; Besombes, JP; Bounhoure, JP; Fauvel, JM; Galinier, M; Mazerolles, M; Rami, J | 1 |
| Blasig, IE; Davies, KJ; Grune, T; Haseloff, R; Roloff, B; Sitte, N | 1 |
| de Groot, H; Kirsch, M; Lomonosova, EE; Rauen, U | 1 |
| Branka, JE; Dreno, B; Jarry, A; Laboisse, CL; Sainte-Marie, I; Tenaud, I; Vallette, G | 1 |
| de Groot, H; Kirsch, M; Korth, HG; Lomonosova, EE; Sustmann, R | 1 |
| Davies, MJ; Stocker, R; Thomas, SR | 1 |
| Maruyama, W; Naoi, M; Takahashi, T | 1 |
| Hogg, N; Kalyanaraman, B; Konorev, EA | 1 |
| DuVall, MD; Fuller, CM; Matalon, S; Zhu, S | 1 |
| Helton, ES; Jackson, RM; Parish, G | 1 |
| Bocca, AL; Campanelli, AP; Cunha, FQ; Figueiredo, F; Furlanetto, AB; Hayashi, EE; Pinheiro, AG | 1 |
| Mayer, B; Pfeiffer, S | 1 |
| Kim, WK; Ko, KH | 1 |
| Blaylock, MG; Cuthbertson, BH; Ferguson, NR; Galley, HF; Webster, NR | 1 |
| Aguirre, DE; Fink, MP; Menconi, MJ; Smith, M; Unno, N | 1 |
| Asada, S; Fukuda, K; Oh, M; Tanaka, S; Yasuda, Y | 1 |
| Maisch, B | 1 |
| Hogg, N; Joseph, J; Kalyanaraman, B; Konorev, E; Singh, RJ | 1 |
| Goss, SP; Hogg, N; Kalyanaraman, B | 1 |
| Hirata, K; Kanazawa, H; Okamoto, T; Shiraishi, S; Yoshikawa, J | 1 |
| Regoli, F; Winston, GW | 1 |
| Niki, E; Noguchi, N; Shi, H; Xu, Y | 1 |
| Roberts, LJ; van der Veen, RC | 1 |
| Edelstein, CL; Gengaro, PE; Ling, H; Nemenoff, RA; Schrier, RW; Wangsiripaisan, A | 1 |
| Celan, I; Chazotte, L; Mower, HF; Ohshima, H; Pignatelli, B | 1 |
| Angioï, M; Bertrand, A; Branly, F; Brouant, B; Danchin, N; Grentzinger, A; Juillière, Y; Karcher, G; Marie, PY; Olivier, P; Virion, JM; Zannad, F | 1 |
| Maeda, S; Saeki, M | 1 |
| Grisham, MB; Koyama, S; Robbins, RA; Sato, E; Simpson, KL | 3 |
| Anderson, RL; Hurley, JV; Lepore, DA; Morrison, WA; Stewart, AG; Tomasi, A | 1 |
| Callahan, LA; DiMarco, A; Nethery, D; Nosek, TM; Stofan, D; Supinski, G | 1 |
| de Groot, H; Kirsch, M | 2 |
| Beckman, JS; Crow, JP; MacMillan-Crow, LA; Takakura, K | 1 |
| Akiyama, K; Aoyagi, K; Hirayama, A; Koyama, A; Nagase, S; Narita, M; Ohba, S; Shahrzad, S; Takemura, K; Tomida, C | 1 |
| Isobe, K; Maruyama, W; Naoi, M; Oh-hashi, K; Takahashi, T; Yi, H | 1 |
| Deeb, RS; Hajjar, DP; Upmacis, RK | 1 |
| Morioka, N; Okatani, Y; Wakatsuki, A; Watanabe, K | 1 |
| Chesnais, JM; Fischmeister, R; Mery, PF | 1 |
| Elstner, EF; Schneider, D | 1 |
| Hirata, K; Kanazawa, H; Yoshikawa, J | 2 |
| Jan, KY; Liu, F | 1 |
| Packer, L; Park, YC; Rimbach, G; Virgili, F | 1 |
| Hayakawa, A; Hayashi, S; Kobayashi, T; Negita, M; Ogawa, H; Takagi, H; Yokoyama, I | 1 |
| Althaus, JS; Borosky, S; Carroll, RT; Galatsis, P; Hall, ED; Kopec, KK; Kumar, V | 1 |
| Basiouny, KF; Crow, JP; Matalon, S; Zhu, S | 1 |
| Ju, C; Kim, HC; Kim, WK; Ko, KH; Oh, YK; Ryu, JR; Shin, CY; Yoon, KN | 1 |
| Meinhardt, G; Sechtem, U | 1 |
| Chen, Q; Gole, M; Gow, AJ; Ischiropoulos, H; Lee, VM; Themistocleous, M | 1 |
| Beukelman, CJ; Folkerts, G; Koster, AS; Muijsers, RB; Nijkamp, FP; Postma, DS; van Den Worm, E | 1 |
| Choi, JH; Chung, HY; Kim, KW; Kim, MS; Lee, KH; Yang, R; Yokozawa, T | 1 |
| Byrne, L; Croft, KD; Morton, LW; Puddey, IB | 1 |
| Muriel, P; Sandoval, G | 1 |
| Akiba, J; Hikichi, T; Kado, M; Yanagiya, N; Yoshida, A | 1 |
| Kamisaki, Y; Maeda, S; Saeki, M | 1 |
| Buckley, BJ; Whorton, AR | 1 |
| Ekelund, UE; Georgakopoulos, D; Hare, JM; Harrison, RW; Isoda, T; Kass, DA; Ozaki, M; Paolocci, N; Vandegaer, K | 1 |
| Cacho, J; Crespo, MD; Herrera, E; Klatt, P; Ramos, P | 1 |
| Cai, L; Kang, YJ; Klein, JB | 1 |
| Holbrook, NJ; Klotz, LO; Schieke, SM; Sies, H | 1 |
| Deby-Dupont, G; Hans, P; Kohnen, S; Lamy, M; Mathy-Hartert, M; Mouithys-Mickalad, A | 1 |
| Gilkeson, GS; Keng, T; Privalle, CT; Weinberg, JB | 1 |
| Daiber, A; Herold, S; Namgaladze, D; Peterson, JA; Schöneich, C; Ullrich, V | 1 |
| Bothwell, M; Gunther, EC; Yuen, EC | 1 |
| Choi, CR; Choi, IY; Chung, JH; Kim, HC; Kim, WK; Ko, KH; Lee, SJ; Nam, W; Noh, SK; Park, JS; Shin, CY; Shin, DH | 1 |
| Hodges, GR; Ingold, KU; Marwaha, J; Paul, T | 1 |
| Camhi, SL; Koyama, S; Nelson, DK; Robbins, RA; Sato, E | 1 |
| Campos-Pérez, JJ; Ellis, AE; Secombes, CJ | 1 |
| Isobe, K; Maruyama, W; Oh-Hashi, K | 1 |
| Buccafusco, JJ; Jonnala, RR | 1 |
| Connelly, PW; Crandall, I; Guy, RA; Kain, KC; Maguire, GF | 1 |
| Blanchard, B; Ducrocq, C; Servy, C | 1 |
| Cheong, YP; Chung, YT; Kim, BR; Kim, MS; Kim, TY; Lee, KM; Oh, J; Park, R; So, HS; Son, Y | 1 |
| Douglass, LW; Ledbetter, TK; Paape, MJ | 1 |
| Barbouti, A; Doulias, PT; Galaris, D; Ischiropoulos, H | 1 |
| Leong, SK; Ruan, RS; Yeoh, KH | 1 |
| Alcón, S; Camello, PJ; Hemming, JM; Jennings, L; Mawe, GM; Morales, S; Pozo, MJ | 1 |
| Camhi, SL; Hoyt, JC; Nelson, DK; Robbins, RA; Robinson, VK; Sato, E | 1 |
| Ishii, H; Miura, S; Watanabe, N; Zeki, S | 1 |
| Ahmed, Z; Connelly, PW; Draganov, D; Emili, A; Kuksis, A; La Du, BN; Maguire, GF; Ravandi, A | 1 |
| Blay, WM; Heintz, NH; Hemenway, DR; Janssen-Heininger, YM; Persinger, RL | 1 |
| Berrih-Aknin, S; Gaudry-Talarmain, YM; Moulian, N; Serraf, A; Truffault, F | 1 |
| Niki, E; Noguchi, N; Satoh, K; Takabe, W; Uchida, K; Yamada, S | 1 |
| Choi, JW; Kim, H; Kim, W; Ko, KH; Ryu, JH; Ryu, JR; Shin, CY | 1 |
| Diez-Orejas, R; Gil, C; Molero, G; Moro, MA; Nombela, C; Sánchez-Pérez, M | 1 |
| Feix, J; Hogg, N; Joseph, J; Kalyanaraman, B; Zhang, H | 1 |
| Edelstein, C; Gengaro, P; Lelamali, K; Schrier, RW; Wang, W | 1 |
| Créminon, C; Eligini, S; Habib, A; Lebret, M; Lévy-Toledano, S; Maclouf, J | 1 |
| Douglas, DJ; Mauk, AG; Stocker, R; Witting, PK | 1 |
| Gupta, MP; Hart, CM; Knepler, JL; Ober, MD; Patterson, C; Pavalko, F; Taher, LN | 1 |
| Assem, EK; Moulson, A; Pearce, FL; Peh, KH; Wan, BY | 1 |
| Ducrocq, C; Gaudry-Talarmain, YM; Guermonprez, L | 1 |
| Del Carlo, M; Loeser, RF | 1 |
| Choi, JS; Chung, HY; Kim, AR; Kim, JE; Zou, Y | 1 |
| Drapier, JC; Soum, E | 1 |
| Kikura-Hanajiri, R; Lunte, SM; Martin, RS | 1 |
| McConnell, P; Reasor, MJ; Van Dyke, K | 1 |
| Daig, U; Krämer, S; Liefeldt, L; Martini, S; Neumayer, HH; Peters, H; Rückert, M; Schäper, F | 1 |
| Gugliucci, A | 1 |
| Choi, JB; Igarashi, Y; Kashiwagi, A; Kawamori, R; Maegawa, H; Mineki, R; Murayama, K; Nomiyama, T; Ogihara, T; Taka, H; Tanaka, Y; Uchida, T; Uchino, H; Watada, H | 1 |
| Fortepiani, LA; Reckelhoff, JF | 1 |
| Abiru, S; Eguchi, K; Ishibashi, H; Komori, A; Maeda, Y; Migita, K; Nakamura, M; Takii, Y; Yatsuhashi, H; Yokoyama, T | 1 |
| Bottari, SP; Garrido, MR; Levy, P; Pinzar, E; Wang, T; Xu, W | 1 |
| Aoki, K; Kato, S; Saso, N; Sato, H; Sugiyama, Y | 1 |
| Münzel, T | 1 |
| Arai, T; Fujieda, S; Kobayashi, S; Kuramochi, K; Nakajima, M; Nakazaki, A; Ohnishi, K; Saitoh, Y; Sugawara, F; Takeuchi, T; Watanabe, N | 1 |
| Kim, JM; Kim, SY; Koo, JY; Koo, YK; Oh, D; Park, S; Yun-Choi, HS | 1 |
| Antunes, E; Cardoso, MH; De Nucci, G; Lilla, S; Marcondes, S; Morganti, RP; Murad, F | 1 |
| Iliescu, R; Lopez-Ruiz, AF; Reckelhoff, JF | 1 |
| Amit, T; Bar-Am, O; Gross, Z; Kupershmidt, L; Mahammed, A; Mandel, S; Okun, Z; Saltsman, I; Youdim, MB | 1 |
| Förstermann, U; Li, H | 1 |
| Batugo, M; Borghi, V; Brambilla, S; Carreiro, ST; Chiroli, V; Chong, WK; Gale, DC; Guzzetta, M; Impagnatiello, F; Krauss, AH; Ongini, E; Prasanna, G | 1 |
| Neumaier, J | 1 |
| Askwith, T; Eggo, MC; Stevens, MJ; Zeng, W | 1 |
9 review(s) available for nitrates and molsidomine
| Article | Year |
|---|---|
Pharmacologic treatment of portal hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Clonidine; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Metoclopramide; Molsidomine; Nitrates; Nitroglycerin; Serotonin Antagonists; Somatostatin; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins | 1992 |
Clinical comparison of nitrates and sydnonimines.
Topics: Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Heart Failure; Molsidomine; Nitrates | 1991 |
Response of coronary arteries to nitrates, the EDRF-donor SIN-1, and calcium antagonists.
Topics: Calcium Channel Blockers; Coronary Vasospasm; Coronary Vessels; Humans; Molsidomine; Nitrates; Nitroglycerin; Vasodilation | 1991 |
[Effects of antianginal agents on myocardial blood flow].
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Circulation; Humans; Molsidomine; Nitrates; Oxyfedrine; Sydnones; Vasodilator Agents | 1982 |
[Effect of nitrates, nitrate-like substances, calcium antagonists and beta-adrenergic receptor blockers on peripheral circulation].
Topics: Adrenergic beta-Antagonists; Amyl Nitrite; Angina Pectoris; Animals; Blood Circulation; Calcium Channel Blockers; Humans; Isosorbide Dinitrate; Molsidomine; Muscle Contraction; Muscles; Nitrates; Nitroglycerin; Nitroprusside; Rats; Sydnones | 1982 |
[Nitric oxide in therapy of angina pectoris: nitrates or molsidomine?].
Topics: Angina Pectoris; Animals; Coronary Circulation; Drug Tolerance; Humans; Molsidomine; Nitrates; Nitric Oxide; Vasodilator Agents | 1997 |
[Nitric oxide donors in therapy of chronic heart failure].
Topics: Chronic Disease; Drug Tolerance; Heart Failure; Hemodynamics; Humans; Molsidomine; Nitrates; Nitric Oxide; Vasodilator Agents | 1997 |
[Recent findings on nitrates: their action, bioactivation and development of tolerance].
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Coronary Disease; Drug Tolerance; Endothelium, Vascular; Guanylate Cyclase; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Oxidative Stress; Pentaerythritol Tetranitrate; Reactive Oxygen Species; Vasodilation; Vasodilator Agents | 2008 |
[The pharmacology of nitric oxide and nitrates].
Topics: Animals; Humans; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Vasodilator Agents | 2010 |
6 trial(s) available for nitrates and molsidomine
| Article | Year |
|---|---|
[Effect of vasodilator agents on the effectiveness of the complex treatment of patients with ischemic heart disease and congestive heart failure].
Topics: Aged; Cardiomyopathy, Dilated; Clinical Trials as Topic; Coronary Disease; Digoxin; Drug Synergism; Drug Therapy, Combination; Female; Furosemide; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Myocardial Contraction; Nitrates | 1989 |
Effectiveness of molsidomine in the long-term treatment of exertional angina pectoris and chronic congestive heart failure.
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Electrocardiography; Heart Failure; Heart Rate; Humans; Molsidomine; Nitrates; Oxadiazoles; Pulmonary Artery; Sydnones; Vasodilator Agents | 1985 |
[Hemodynamics effects of continuous infusion of molsidomine and nitrates and subsequent oral medication in therapy of acute myocardial infarct].
Topics: Administration, Oral; Aged; Aged, 80 and over; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Myocardial Infarction; Nitrates; Nitroglycerin; Vasodilator Agents | 1994 |
Comparison of the hemodynamic responses to molsidomine and isosorbide dinitrate in congestive heart failure.
Topics: Biotransformation; Double-Blind Method; Drug Tolerance; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Molsidomine; Nitrates; Pulmonary Wedge Pressure | 1994 |
Nasal nitric oxide concentration is decreased in heart failure patients receiving nitrates.
Topics: Adult; Aged; Female; Heart Diseases; Humans; Male; Middle Aged; Molsidomine; Nasal Cavity; Nitrates; Nitric Oxide; Respiration; Respiration, Artificial; Trachea | 1998 |
Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite.
Topics: Adenosine Triphosphatases; Adult; Antioxidants; Enzyme Inhibitors; Female; Humans; Lipoproteins, LDL; Male; Mass Spectrometry; Molsidomine; Nitrates; Oxidants; Oxidation-Reduction; Plasma; Ubiquinone; Vitamin E | 1998 |
181 other study(ies) available for nitrates and molsidomine
| Article | Year |
|---|---|
Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.
Topics: Animals; Antioxidants; Aorta, Thoracic; Drug Tolerance; Female; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Nitrates; Nitroglycerin; Parasympatholytics; Rabbits; Vasodilator Agents | 1992 |
[Anti-ischemia drug therapy].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Fibrinolytic Agents; Humans; Molsidomine; Nitrates | 1991 |
Molecular mechanisms of nitrovasodilator bioactivation.
Topics: Amyl Nitrite; Enzyme Activation; Guanylate Cyclase; Isosorbide Dinitrate; Methemoglobin; Molsidomine; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins | 1991 |
Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity.
Topics: Animals; Arteries; Cattle; Coronary Vessels; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitric Oxide; Nitroglycerin; Vasodilator Agents | 1990 |
Reduced nitric oxide release causes nitrate tolerance in the intact coronary circulation.
Topics: Animals; Bradykinin; Cell Line; Coronary Vessels; Cyclic GMP; Drug Tolerance; Fibroblasts; Heart; Iloprost; Lung; Molsidomine; Myocardium; Nitrates; Nitric Oxide; Nitroglycerin; Rabbits; Rats; Vasodilator Agents | 1991 |
Inhibition of platelet activating factor-induced platelet aggregation by molsidomine, SIN-1, and nitrates in vitro and ex vivo.
Topics: Cyclic GMP; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitrates; Nitric Oxide; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1989 |
On the mechanism of NO release from sydnonimines.
Topics: Animals; Enzyme Activation; Guanylate Cyclase; Liver; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Oxygen Consumption; Rats; Superoxides | 1989 |
The pharmacologic management of coronary artery disease in 1986.
Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Critical Care; Humans; Molsidomine; Nitrates | 1986 |
Mode of action of nitrates with regard to vasodilatation and tolerance.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilation | 1986 |
[Comparison of the effects of SIN-1, sodium nitroprusside and nitrate derivatives on the inhibition of blood platelet aggregation and activation of soluble platelet guanylate-cyclase].
Topics: Blood Platelets; Ferricyanides; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Nitroprusside; Platelet Aggregation | 1987 |
Mechanism of vasodilation by nitrates: role of cyclic GMP.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilator Agents | 1987 |
Direct comparison of the effects of nitroprusside, SIN 1, and various nitrates on platelet aggregation and soluble guanylate cyclase activity.
Topics: Adult; Blood Platelets; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Nitrates; Nitroprusside; Platelet Aggregation; Solubility | 1988 |
[Mechanism of the vasodilating effect and blood platelet- antiaggregating activity of molsidomine and SIN-1].
Topics: Animals; Cyclic GMP; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Platelet Aggregation; Vasodilation | 1987 |
Effects of nitrates in various vascular sections and regions.
Topics: Animals; Arteries; Arterioles; Blood Vessels; Dogs; Drug Tolerance; Hemodynamics; Molsidomine; Nitrates; Nitroglycerin; Vasodilation; Veins | 1986 |
Comparison of the influence of nitrates, molsidomine and SIN-1, a molsidomine metabolite in acute coronary insufficiency.
Topics: Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Ergonovine; Humans; Molsidomine; Myocardial Infarction; Nitrates; Platelet Aggregation | 1985 |
Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Catalase; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Mice; Molsidomine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Superoxides; Xanthine Oxidase | 1993 |
Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells.
Topics: Animals; Dihydroxyphenylalanine; Molsidomine; Nitrates; Oxidation-Reduction; PC12 Cells; Rats; Tyrosine | 1995 |
Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model.
Topics: Base Sequence; DNA Primers; Genes, Bacterial; Glutathione; Microbial Sensitivity Tests; Molecular Sequence Data; Molsidomine; Mutagenesis; Nitrates; Nitric Oxide; Nitroso Compounds; Oxidation-Reduction; Polyamines; S-Nitrosoglutathione; Salmonella typhimurium; Species Specificity; Vasodilator Agents | 1995 |
Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite.
Topics: Antihypertensive Agents; Arachidonic Acid; Arteriosclerosis; Catalysis; Humans; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Platelet Aggregation Inhibitors; Prostaglandins F, Synthetic; Superoxide Dismutase; Superoxides; Vasodilator Agents | 1995 |
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cysteine; DNA; Free Radicals; Kinetics; Molsidomine; N-Methylaspartate; Necrosis; Neurons; Nitrates; Nitric Oxide; Oxidative Stress; Rats; S-Nitrosothiols; Superoxide Dismutase; Superoxides | 1995 |
Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cattle; Deoxyguanosine; Deoxyribonucleotides; DNA; DNA Damage; Free Radical Scavengers; Humans; Molsidomine; Nitrates; Nitric Oxide; Oxidative Stress; Superoxides | 1995 |
Elevation of circulating NO: its effects on hemodynamics and vascular smooth muscle cell proliferation in rats.
Topics: Animals; Carotid Arteries; Cell Division; DNA; Fluorometry; Hemodynamics; Male; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Wistar | 1995 |
Formation of F2-isoprostanes during the oxidation of human low density lipoprotein by peroxynitrite.
Topics: Arachidonic Acids; Dinoprost; Humans; Kinetics; Lipoproteins, LDL; Molsidomine; Nitrates; Oxidation-Reduction; Platelet Aggregation Inhibitors | 1995 |
The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli.
Topics: Escherichia coli; Free Radicals; Hydrogen Peroxide; Molsidomine; Nitrates; Nitric Oxide; Oxyhemoglobins; Toxicity Tests | 1995 |
Sensitivity of the essential zinc-thiolate moiety of yeast alcohol dehydrogenase to hypochlorite and peroxynitrite.
Topics: Alcohol Dehydrogenase; Cysteine; Histidine; Hydrogen Peroxide; Hypochlorous Acid; Kinetics; Molsidomine; Nitrates; Sulfhydryl Compounds; Taurine; Zinc | 1995 |
Concurrent generation of nitric oxide and superoxide damages surfactant protein A.
Topics: Humans; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Penicillamine; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Reactive Oxygen Species; Rhodamines; S-Nitroso-N-Acetylpenicillamine; Superoxides; Time Factors | 1994 |
Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents.
Topics: Adenosine Diphosphate Ribose; Binding Sites; Borates; Dithiothreitol; Glyceraldehyde-3-Phosphate Dehydrogenases; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Sulfhydryl Compounds; Superoxide Dismutase | 1994 |
Reaction of peroxynitrite with oxyhaemoglobin: interference with photometrical determination of nitric oxide.
Topics: Electrochemistry; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Oxyhemoglobins; Photochemistry; Spectrophotometry; Superoxide Dismutase | 1994 |
Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates.
Topics: Benzoates; Cyclic N-Oxides; Deoxyribose; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Hydroxyl Radical; Models, Chemical; Molsidomine; Nitrates; Oxidation-Reduction | 1994 |
Long-term administration of L-arginine, L-NAME, and the exogenous NO donor molsidomine modulates urinary nitrate and cGMP excretion in rats.
Topics: Animals; Arginine; Blood Pressure; Body Weight; Cholesterol; Chromatography, Gas; Cyclic GMP; Heart; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Time Factors | 1994 |
Direct inhibition of platelet function by organic nitrates via nitric oxide formation.
Topics: Adenosine Triphosphate; Animals; Anisotropy; Blood Platelets; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Esters; Fibroblasts; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thromboxanes | 1993 |
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.
Topics: Animals; Brain; Cell Death; Cells, Cultured; Cysteine; Free Radicals; Molsidomine; Neurons; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxidation-Reduction; Rats; Receptors, N-Methyl-D-Aspartate; S-Nitrosothiols; Superoxides | 1993 |
Modulation of iron regulatory protein functions. Further insights into the role of nitrogen- and oxygen-derived reactive species.
Topics: Aconitate Hydratase; Animals; Cell Line; Enzyme Inhibitors; Ferritins; Hemoglobins; Hydrogen Peroxide; Iron-Regulatory Proteins; Mice; Molsidomine; Nitrates; Reactive Oxygen Species; RNA-Binding Proteins; RNA, Messenger; Superoxide Dismutase; Superoxides | 1996 |
Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose.
Topics: Animals; Brain; Dithiothreitol; Electron Transport Complex IV; Glucose; Glutathione; Kinetics; Mitochondria; Molsidomine; Nitrates; Nitric Oxide; Oxygen Consumption; Rats; Submitochondrial Particles; Superoxide Dismutase | 1996 |
Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro.
Topics: Animals; Axons; Cells, Cultured; Cysteine; Free Radical Scavengers; Mercaptoethanol; Molsidomine; Neurites; Nitrates; Nitric Oxide; Nitrites; Nitroprusside; Nitroso Compounds; Penicillamine; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Signal Transduction; Sulfhydryl Reagents; Time Factors; Vasodilator Agents; Xenopus laevis | 1996 |
Enhanced NO production during Mg deficiency and its role in mediating red blood cell glutathione loss.
Topics: Animals; Electron Spin Resonance Spectroscopy; Erythrocytes; Glutathione; Hemoglobins; Magnesium Deficiency; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Weight Gain | 1996 |
Peroxynitrite modulates receptor-activated Ca2+ signaling in vascular endothelial cells.
Topics: Animals; Bradykinin; Calcium; Cattle; Cells, Cultured; Endothelium, Vascular; Inositol 1,4,5-Trisphosphate; Molsidomine; Nitrates; Nitric Oxide; Receptors, Cell Surface; Signal Transduction | 1996 |
A precursor of the nitric oxide donor SIN-1 modulates the stress protein heme oxygenase-1 in rat liver.
Topics: Animals; Blotting, Northern; Enzyme Induction; Female; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Humans; Kinetics; Liver; Molsidomine; Nitrates; Nitrites; Prodrugs; Rats; Rats, Inbred Lew; RNA, Messenger; Transcription, Genetic | 1996 |
Nitration of surfactant protein A (SP-A) tyrosine residues results in decreased mannose binding ability.
Topics: Animals; Binding Sites; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lipid Peroxidation; Liposomes; Mannose; Molsidomine; Nitrates; Nitric Oxide; Oxidative Stress; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Superoxides; Tetranitromethane; Tyrosine | 1996 |
Effect of ITF 296 on total effective vascular compliance in the anesthetized dog under autonomic blockade.
Topics: Anesthesia; Animals; Autonomic Nerve Block; Benzoxazines; Blood Pressure; Dogs; Female; Hemodynamics; Male; Molsidomine; Muscle Tonus; Nitrates; Nitroglycerin; Oxazines; Vascular Resistance; Vasodilator Agents | 1995 |
The nitrate ester ITF 296 relaxes isolated canine arteries and veins.
Topics: Animals; Arteries; Benzoxazines; Dogs; Electrophysiology; Endothelium, Vascular; Female; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Oxazines; Vasodilator Agents; Veins | 1995 |
Peroxynitrite augments fMLP-stimulated chemiluminescence by neutrophils in human whole blood.
Topics: Antioxidants; Azides; Benzoquinones; Catalase; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Free Radical Scavengers; Humans; Lipoxygenase Inhibitors; Luminescent Measurements; Luminol; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrates; Nitric Oxide; omega-N-Methylarginine; Proadifen; Reactive Oxygen Species; Respiratory Burst; Sodium Azide; Superoxide Dismutase; Taurine | 1996 |
DNA damage by peroxynitrite characterized with DNA repair enzymes.
Topics: Butanols; Chromatography, High Pressure Liquid; DNA; DNA Damage; DNA Repair; Endonucleases; Free Radical Scavengers; Hydroxyl Radical; Molsidomine; Nitrates; tert-Butyl Alcohol | 1996 |
Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper.
Topics: Amidines; Butylated Hydroxytoluene; Copper; Hydroxycholesterols; Ketocholesterols; Lipoproteins, LDL; Molsidomine; Molybdenum; Myoglobin; Nitrates; Oxidation-Reduction; Superoxide Dismutase; Vitamin E | 1996 |
Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
Topics: Animals; Arachidonic Acid; Cell Line; Enzyme Activation; Glutathione Peroxidase; Kinetics; Macrophages; Metalloporphyrins; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Salicylates; Superoxides | 1996 |
Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine.
Topics: Amidines; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Molsidomine; Nitrates; Peroxides; Piperidines; Reactive Oxygen Species; Spin Labels; Superoxides; Triacetoneamine-N-Oxyl | 1997 |
Evidence for peroxynitrite as an oxidative stress-inducing compound of aqueous cigarette smoke fractions.
Topics: 3T3 Cells; Animals; Catalase; Enzyme Induction; Gene Expression; Genes, fos; Glutathione; Guanylate Cyclase; Mice; Molsidomine; Nicotiana; Nitrates; Nitric Oxide; Oxidative Stress; Plants, Toxic; Rats; Smoke; Superoxide Dismutase | 1997 |
Reactions of peroxynitrite with gamma-tocopherol.
Topics: Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Vitamin E | 1997 |
Interference of carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions.
Topics: Animals; Benzoates; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Serum Albumin, Bovine; Swine; Tyrosine | 1997 |
Release of glutathione from erythrocytes and other markers of oxidative stress in carbon monoxide poisoning.
Topics: Animals; Biological Transport; Biomarkers; Blood Platelets; Carbon Monoxide Poisoning; Cytochalasin B; Enzyme Inhibitors; Erythrocyte Count; Erythrocyte Membrane; Erythrocytes; Glutathione; Glutathione Disulfide; Hexoses; Male; Molsidomine; Neutrophils; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 1997 |
Role of inhibition of nitric oxide production in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Arterioles; Blood Pressure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Male; Molsidomine; Monocrotaline; Nitrates; Nitric Oxide; Poisons; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Weight Gain | 1997 |
3-Morpholino-sydnonimine-induced suppression of human neutrophil degranulation is not mediated by cyclic GMP, nitric oxide or peroxynitrite: inhibition of the increase in intracellular free calcium concentration by N-morpholino-iminoacetonitrile, a metabo
Topics: Acetonitriles; Calcium; Cell Degranulation; Cyclic GMP; Humans; Molsidomine; Morpholines; Neutrophils; Nitrates; Nitric Oxide | 1997 |
Nitric oxide synergistically enhances DNA strand breakage induced by polyhydroxyaromatic compounds, but inhibits that induced by the Fenton reaction.
Topics: Catechols; Copper; DNA Damage; Drug Synergism; Hydrogen Peroxide; Hydroquinones; Iron; Molsidomine; Nitrates; Nitric Oxide; Plasmids; Reactive Oxygen Species | 1997 |
The oxidation of selenocysteine is involved in the inactivation of glutathione peroxidase by nitric oxide donor.
Topics: Amino Acid Sequence; Apoptosis; Glutathione Peroxidase; Molecular Sequence Data; Molsidomine; Nitrates; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Selenocysteine | 1997 |
Redox modulation of iron regulatory proteins by peroxynitrite.
Topics: Aconitate Hydratase; Animals; Cells, Cultured; Cysteine; Ferritins; Humans; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Mercaptoethanol; Mice; Models, Chemical; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger | 1997 |
Ursodeoxycholate inhibits induction of NOS in human intestinal epithelial cells and in vivo.
Topics: Adenocarcinoma; Animals; Cell Line, Transformed; Cell Survival; Enzyme Induction; Enzyme Repression; Humans; Intestinal Mucosa; Intestinal Neoplasms; Kinetics; Lipopolysaccharides; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Synthase; Nitrites; Oxygen Consumption; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Ursodeoxycholic Acid | 1997 |
Peroxynitrite-induced hemolysis of human erythrocytes and its inhibition by antioxidants.
Topics: Acetylcysteine; Albumins; Amidines; Antioxidants; Azoles; Catalase; Chromans; Erythrocytes; Glutathione; Hematocrit; Hemolysis; Humans; Isoindoles; Molsidomine; Nitrates; Organoselenium Compounds; Uric Acid; Vitamin E | 1997 |
Prostaglandin E2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Microglia; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Penicillamine; Prostaglandin-Endoperoxide Synthases; Rats; S-Nitroso-N-Acetylpenicillamine | 1997 |
Nitric oxide-induced hyperpermeability of human intestinal epithelial monolayers is augmented by inhibition of the amiloride-sensitive Na(+)-H+ antiport: potential role of peroxynitrous acid.
Topics: Amiloride; Cell Membrane Permeability; Colonic Neoplasms; Deferoxamine; Humans; Intestinal Mucosa; Membrane Potentials; Molsidomine; Nitrates; Nitric Oxide; Nitrous Acid; Peroxynitrous Acid; Sodium-Hydrogen Exchangers; Superoxides; Tumor Cells, Cultured | 1997 |
Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS.
Topics: Animals; Apoptosis; Cell Line; Epithelial Cells; Genes, fos; Genes, jun; Hydrogen Peroxide; Lung; Molsidomine; Nitrates; Nitric Oxide; Penicillamine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Reactive Oxygen Species; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Spermine; Transcription, Genetic | 1997 |
Effect of anti-oxidants on the degradation of SIN-1.
Topics: Antioxidants; Antipyrine; Biotransformation; Cytochrome c Group; Hydrogen Peroxide; Kinetics; Molsidomine; Nitrates; Oxidation-Reduction; Superoxide Dismutase | 1997 |
Peroxynitrite-induced toxicity in cultured astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Glutathione; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Molsidomine; Nitrates; Nitric Oxide; Nitroso Compounds; Oxidants; Rats; S-Nitrosoglutathione; Superoxides | 1997 |
Nitric oxide and peroxynitrite affect differently acetylcholine release, choline acetyltransferase activity, synthesis, and compartmentation of newly formed acetylcholine in Torpedo marmorata synaptosomes.
Topics: Acetylcholine; Animals; Calcimycin; Cell Compartmentation; Choline O-Acetyltransferase; Electric Organ; Enzyme Inhibitors; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Potassium Chloride; Synaptosomes; Torpedo | 1997 |
Nitric oxide and peroxynitrite-mediated pulmonary cell death.
Topics: Acetylcysteine; Animals; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Epithelial Cells; Kinetics; Lung; Male; Molsidomine; Nitrates; Nitric Oxide; Nitrogen Oxides; Oxidants; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Spermine | 1998 |
The effects of nitric oxide and peroxynitrite on interleukin-8 and elastase from lipopolysaccharide-stimulated whole blood.
Topics: Free Radical Scavengers; Humans; In Vitro Techniques; Interleukin-8; Leukocyte Elastase; Lipopolysaccharides; Male; Molsidomine; Nitrates; Nitric Oxide; Triazoles | 1998 |
Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart.
Topics: Animals; Creatine Kinase; Glutathione; L-Lactate Dehydrogenase; Male; Molsidomine; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Perfusion; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasodilator Agents | 1997 |
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells.
Topics: Adenosine Triphosphate; Caco-2 Cells; DNA Damage; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Molsidomine; Nitrates; Nitric Oxide; Penicillamine; Permeability; Poly(ADP-ribose) Polymerases; S-Nitroso-N-Acetylpenicillamine | 1998 |
Nitric oxide superoxide and peroxynitrite modulate osteoclast activity.
Topics: Animals; Animals, Newborn; Bone Resorption; Calcium; Catalase; Cells, Cultured; Cyclic GMP; Enzyme Activation; Hydrogen Peroxide; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Osteoclasts; Rats; Rats, Sprague-Dawley; Superoxides; Thionucleotides | 1998 |
Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome.
Topics: Aconitate Hydratase; Cysteine Endopeptidases; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Hydrolysis; Molsidomine; Multienzyme Complexes; Nitrates; Oxidative Stress; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1998 |
The critical role of Hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide.
Topics: Animals; Buffers; Catalase; Cell Death; Cell Line; Fibroblasts; HEPES; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Mice; Molsidomine; Nitrates | 1998 |
Control of growth and differentiation of normal human epithelial cells through the manipulation of reactive nitrogen species.
Topics: Catalase; Cell Differentiation; Cell Division; Cyclic N-Oxides; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; Hydrazines; Imidazoles; Keratinocytes; Molsidomine; Nitrates; Nitric Oxide; Superoxide Dismutase; Thymidine | 1998 |
Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.
Topics: Amines; Animals; Bicarbonates; Carbon Dioxide; Cattle; HEPES; Hydrogen Peroxide; Molsidomine; Nitrates; Oxygen; Superoxide Dismutase; Tryptophan | 1998 |
(-)-Deprenyl protects human dopaminergic neuroblastoma SH-SY5Y cells from apoptosis induced by peroxynitrite and nitric oxide.
Topics: Antiparkinson Agents; Apoptosis; DNA Damage; Dopamine; Electrophoresis, Agar Gel; Humans; Molsidomine; Monoamine Oxidase Inhibitors; Neuroblastoma; Nitrates; Nitric Oxide; Oxidants; Pyridines; Selegiline; Tumor Cells, Cultured | 1998 |
Rapid and irreversible inhibition of creatine kinase by peroxynitrite.
Topics: Acetonitriles; Animals; Creatine Kinase; Enzyme Activation; Enzyme Inhibitors; Enzyme Reactivators; Glutathione; Glutathione Disulfide; Kinetics; Molsidomine; Morpholines; Nitrates; Nitric Oxide; Oxidants; Rabbits; Sulfhydryl Compounds; Superoxides | 1998 |
Peroxynitrite inhibits amiloride-sensitive Na+ currents in Xenopus oocytes expressing alpha beta gamma-rENaC.
Topics: Amiloride; Animals; Calcium; Electric Conductivity; Epithelial Sodium Channels; Female; Molsidomine; Nitrates; Oocytes; Oxidants; Rats; Sodium; Sodium Channels; Tetranitromethane; Xenopus laevis | 1998 |
Peroxynitrite modulates MnSOD gene expression in lung epithelial cells.
Topics: Animals; Blotting, Northern; Cell Line; Epithelial Cells; Gene Expression; Humans; Hydrogen Peroxide; Luciferases; Lung; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Rats; Recombinant Fusion Proteins; RNA, Messenger; Superoxide Dismutase | 1998 |
Treatment of Paracoccidioides brasiliensis-infected mice with a nitric oxide inhibitor prevents the failure of cell-mediated immune response.
Topics: Animals; Cell-Free System; Drug Administration Schedule; Immunity, Cellular; Injections, Intraperitoneal; Lung; Lung Diseases, Parasitic; Lymphocyte Activation; Macrophages, Alveolar; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroarginine; Paracoccidioides; Paracoccidioidomycosis; Penicillamine; Spleen; Tumor Necrosis Factor-alpha | 1998 |
Lack of tyrosine nitration by peroxynitrite generated at physiological pH.
Topics: Carbon Dioxide; Free Radicals; Hydrogen-Ion Concentration; Models, Chemical; Molsidomine; Nitrates; Nitrogen Oxides; Spermine; Tyrosine; Xanthine Oxidase | 1998 |
Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia.
Topics: Animals; Apoptosis; Catalase; Cerebellum; Coculture Techniques; DNA Fragmentation; In Situ Nick-End Labeling; Interferon-gamma; L-Lactate Dehydrogenase; Lipopolysaccharides; Mice; Microglia; Molsidomine; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase | 1998 |
The effect of nitric oxide and peroxynitrite on apoptosis in human polymorphonuclear leukocytes.
Topics: Annexin A5; Apoptosis; Flow Cytometry; Humans; Lipopolysaccharides; Lung; Molsidomine; Neutrophils; Nitrates; Nitric Oxide; Triazoles | 1998 |
Nitric oxide donor-induced hyperpermeability of cultured intestinal epithelial monolayers: role of superoxide radical, hydroxyl radical, and peroxynitrite.
Topics: Antioxidants; Caco-2 Cells; Epithelial Cells; Free Radical Scavengers; Glutathione; Humans; Hydroxyl Radical; Intestinal Absorption; Intestines; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Permeability; Superoxide Dismutase; Superoxides | 1998 |
Concurrent generation of nitric oxide and superoxide inhibits proteoglycan synthesis in bovine articular chondrocytes: involvement of peroxynitrite.
Topics: Animals; Cartilage, Articular; Cattle; Chondrocytes; Immunohistochemistry; Interleukin-1; Molsidomine; Nitrates; Nitric Oxide; Proteoglycans; Superoxides | 1998 |
[Therapy recommendations for adverse effects of Viagra and nitrates (NO-donors)].
Topics: Angina Pectoris; Blood Pressure; Contraindications; Drug Therapy, Combination; Erectile Dysfunction; Humans; Male; Molsidomine; Nicorandil; Nitrates; Nitric Oxide Donors; Piperazines; Purines; Sildenafil Citrate; Sulfones | 1998 |
The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors.
Topics: Animals; Cyclic N-Oxides; Free Radical Scavengers; Hemeproteins; Humans; Imidazoles; Kidney; Liver; Molsidomine; Myocardium; Nitrates; Nitric Oxide Donors; Oxidants; Rats | 1999 |
The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite.
Topics: Chelating Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Liposomes; Molsidomine; Nitrates; Oxidants; Pentetic Acid; Stereoisomerism; Tyrosine; Vitamin E | 1999 |
Inhibition of bronchoprotective effects of beta2-adrenoceptor agonists by peroxynitrite in guinea pig airways.
Topics: Acetylcholine; Adrenergic beta-Agonists; Airway Resistance; Albuterol; Animals; Bronchoconstriction; Colforsin; Guinea Pigs; Isoproterenol; Male; Molsidomine; Nitrates; Penicillamine; Receptors, Adrenergic, beta-1 | 1999 |
Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals.
Topics: Amidines; Antioxidants; Ascorbic Acid; Chromatography, Gas; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Methionine; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Oxidation-Reduction; Peroxides | 1999 |
Formation of phospholipid hydroperoxides and its inhibition by alpha-tocopherol in rat brain synaptosomes induced by peroxynitrite.
Topics: Acetophenones; Animals; Antioxidants; Brain; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Molsidomine; Nitrates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Phospholipids; Rats; Rats, Wistar; Superoxide Dismutase; Synaptosomes; Time Factors; Vitamin E | 1999 |
Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids.
Topics: Animals; Central Nervous System; Dinoprost; Encephalomyelitis, Autoimmune, Experimental; F2-Isoprostanes; Lipid Peroxidation; Mice; Molsidomine; Myelin Proteins; Myelin Sheath; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Penicillamine | 1999 |
Effect of nitric oxide donors on renal tubular epithelial cell-matrix adhesion.
Topics: Animals; Cell Adhesion; Cell Line; Chlorocebus aethiops; Collagen; Epithelial Cells; Fibronectins; Free Radical Scavengers; Kidney Tubules; LLC-PK1 Cells; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Opossums; Superoxides; Swine | 1999 |
Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a postseparation, on-line reduction column and electrochemical detection: results with various nitrating agents.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hypochlorous Acid; Indicators and Reagents; Molsidomine; Nitrates; Nitrites; Nitrogen Oxides; Serum Albumin, Bovine; Sodium Nitrite; Spectrophotometry, Ultraviolet; Spermine; Tyrosine | 1999 |
Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging: evidence of a protective effect of beta-blocking antianginal medications.
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Exercise Test; Female; Humans; Male; Middle Aged; Molsidomine; Myocardial Ischemia; Nitrates; Prognosis; Regression Analysis; Retrospective Studies; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Vasodilator Agents | 1999 |
p130cas is a cellular target protein for tyrosine nitration induced by peroxynitrite.
Topics: Crk-Associated Substrate Protein; Humans; Molsidomine; Neuroblastoma; Nitrates; Nitric Oxide Donors; Oxidants; Phosphoproteins; Phosphorylation; Proteins; Retinoblastoma-Like Protein p130; Tumor Cells, Cultured; Tyrosine | 1999 |
Effects of reactive oxygen and nitrogen metabolites on RANTES- and IL-5-induced eosinophil chemotactic activity in vitro.
Topics: Chemokine CCL5; Chemotaxis; Deferoxamine; Dithiothreitol; Dose-Response Relationship, Drug; Eosinophils; Humans; Hydrazines; Interleukin-5; Leukotriene B4; Molsidomine; Nitrates; Nitric Oxide; Nitrogen; Pteridines; Reactive Oxygen Species; Superoxides; Tyrosine; Xanthine | 1999 |
The survival of skeletal muscle myoblasts in vitro is sensitive to a donor of nitric oxide and superoxide, SIN-1, but not to nitric oxide or peroxynitrite alone.
Topics: Animals; Cell Line; Cell Survival; Molsidomine; Muscle, Skeletal; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxyhemoglobins; Rats; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine Oxidase | 1999 |
Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm.
Topics: Aldehydes; Animals; Calcium; Diaphragm; Kinetics; Lipid Peroxidation; Molsidomine; Muscle Contraction; Nitrates; Nitric Oxide Donors; Rats; Thiobarbituric Acid Reactive Substances | 1999 |
Reaction of peroxynitrite with reduced nicotinamide nucleotides, the formation of hydrogen peroxide.
Topics: Free Radical Scavengers; Free Radicals; Glutathione; Hydrogen Peroxide; Molsidomine; NAD; NADP; Nitrates; Superoxides | 1999 |
Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite.
Topics: Aniline Compounds; Anions; Dithiothreitol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Leukocyte Common Antigens; Models, Molecular; Molsidomine; Nitrates; Nitric Oxide; Nitroso Compounds; Organophosphates; Organophosphorus Compounds; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; S-Nitrosoglutathione; Superoxide Dismutase; Tyrosine | 1999 |
Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals.
Topics: Argininosuccinic Acid; Benzoates; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Feedback; Free Radical Scavengers; Free Radicals; Guanidines; Hydrazines; Hydroxyl Radical; Imidazoles; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Succinates; Superoxide Dismutase | 1999 |
Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Caspases; DNA Fragmentation; Dopamine; Enzyme Activation; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Molsidomine; Neuroblastoma; Neurodegenerative Diseases; Neurons; Nitrates; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Superoxides; Tumor Cells, Cultured | 1999 |
Regulation of prostaglandin H2 synthase activity by nitrogen oxides.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cells, Cultured; Cyclooxygenase 1; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Hydrazines; Isoenzymes; Male; Membrane Proteins; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Penicillamine; Peroxides; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Rats; S-Nitroso-N-Acetylpenicillamine; Sheep; Superoxides | 1999 |
Melatonin inhibits the vasorelaxant action of peroxynitrite in human umbilical artery.
Topics: Antioxidants; Female; Free Radical Scavengers; Humans; In Vitro Techniques; Melatonin; Molsidomine; Nitrates; Nitric Oxide Donors; Pre-Eclampsia; Pregnancy; Umbilical Arteries; Vasodilation | 1999 |
Peroxynitrite is a positive inotropic agent in atrial and ventricular fibres of the frog heart.
Topics: Aminoquinolines; Animals; Atrial Function; Catalase; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Heart Ventricles; Hydroxyl Radical; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide Donors; Oxadiazoles; Oxidants; Quinoxalines; Rana esculenta; Sodium; Sodium-Calcium Exchanger; Ventricular Function | 1999 |
Enhancement by glucose of low density lipoprotein-oxidation by peroxynitrite.
Topics: Glucose; Humans; Kinetics; Lipoproteins, LDL; Male; Mannitol; Middle Aged; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Oxidation-Reduction | 1999 |
Administration of SIN-1 induces guinea pig airway hyperresponsiveness through inactivation of airway neutral endopeptidase.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstriction; Endothelin-1; Enzyme Activation; Glycopeptides; Guinea Pigs; Male; Molsidomine; Neprilysin; Nitrates; Oxidants; Protease Inhibitors; Respiratory System; Substance P; Trachea; Vasodilator Agents | 1999 |
DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells.
Topics: Amitrole; Animals; Antioxidants; Aorta; Arsenites; Bacterial Proteins; Cadmium Chloride; Catalase; Cattle; Cells, Cultured; Chromans; Citrulline; Ditiocarb; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Endothelium, Vascular; Enzyme Inhibitors; Escherichia coli Proteins; Free Radical Scavengers; Hydrogen Peroxide; Molsidomine; Mutagens; N-Glycosyl Hydrolases; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Onium Compounds; Phenanthrolines; Reactive Oxygen Species; Sodium Compounds; Sodium Selenite; Superoxide Dismutase; Superoxides; Thiomalates; Thiourea; Uric Acid | 2000 |
Effect of procyanidins from Pinus maritima on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages.
Topics: Animals; Biflavonoids; Catechin; Cell Line; Cells, Cultured; Endothelium, Vascular; Glutathione; Humans; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Plant Extracts; Proanthocyanidins; Trees | 1999 |
Possible mechanism of bronchoprotection by SIN-1 in anaesthetized guinea pigs: roles of nitric oxide and peroxynitrite.
Topics: Acetylcholine; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Dose-Response Relationship, Drug; Glutathione; Guinea Pigs; Male; Molsidomine; Nebulizers and Vaporizers; Nitrates; Nitric Oxide; Penicillamine; Rhodamines; Time Factors; Vasodilator Agents | 2000 |
Inhibition of MIP-1alpha-induced human neutrophil and monocyte chemotactic activity by reactive oxygen and nitrogen metabolites.
Topics: Chemokine CCL3; Chemokine CCL4; Chemotaxis, Leukocyte; Complement System Proteins; Deferoxamine; Humans; Hydrazines; In Vitro Techniques; Leukotriene B4; Macrophage Inflammatory Proteins; Molsidomine; Monocytes; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants | 2000 |
Free radicals and apoptosis of the endothelial cells.
Topics: Animals; Aorta; Apoptosis; Caspase 3; Caspases; DNA Fragmentation; Endothelium, Vascular; Free Radicals; Mice; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Swine | 2000 |
Reactive nitrogen and oxygen species attenuate interleukin- 8-induced neutrophil chemotactic activity in vitro.
Topics: Chemotaxis, Leukocyte; Humans; Interleukin-8; Leukotriene B4; Molsidomine; Neutrophils; Nitrates; Nitric Oxide Donors; Tyrosine | 2000 |
4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration.
Topics: Animals; Antioxidants; Cyclic N-Oxides; Hydrogen-Ion Concentration; Hydroxylation; L-Lactate Dehydrogenase; Molsidomine; Nitrates; Nitro Compounds; Nitroso Compounds; PC12 Cells; Phenol; Rats; Spin Labels | 2000 |
Carbon dioxide enhances nitration of surfactant protein A by activated alveolar macrophages.
Topics: Carbon Dioxide; Cells, Cultured; Enzyme Activation; Epithelial Cells; Humans; Hypercapnia; Lipid Metabolism; Lipopolysaccharides; Macrophages, Alveolar; Mass Spectrometry; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Respiratory Distress Syndrome; Tyrosine | 2000 |
Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: correlation with mitochondrial dysfunction and subsequent cell death.
Topics: Animals; Astrocytes; Cell Survival; Drug Synergism; Glucose; Glutathione; Membrane Potentials; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Donors; Nitroso Compounds; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione | 2000 |
[Development of nitrate tolerance].
Topics: Angina Pectoris; Animals; Drug Tolerance; Humans; Molsidomine; Nitrates; Vasodilator Agents | 2000 |
Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.
Topics: Acetylcysteine; Animals; Cell Death; Cell Differentiation; Cell Line; Cell Survival; Cyclic GMP; Hydrazines; Molsidomine; Necrosis; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Sulfhydryl Compounds | 2000 |
Apocynin inhibits peroxynitrite formation by murine macrophages.
Topics: Acetophenones; Acridines; Animals; Antioxidants; Cell Line; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Interferon-gamma; Lipopolysaccharides; Luminescent Measurements; Macrophages; Mice; Molsidomine; Nitrates; Nitric Oxide Synthase; Oxidation-Reduction; Rhodamines | 2000 |
The mechanism of nitric oxide and/or superoxide cytotoxicity in endothelial cells.
Topics: Animals; Catalase; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Glutathione; Hemoglobins; Hydrogen Peroxide; Maleates; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Pyrogallol; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides | 2000 |
Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro.
Topics: Caffeic Acids; Coumaric Acids; Humans; Kinetics; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Vitamin E | 2000 |
Nitric oxide and peroxynitrite anion modulate liver plasma membrane fluidity and Na(+)/K(+)-ATPase activity.
Topics: Animals; Cell Fractionation; Cell Polarity; Enzyme Activation; Fluorescence Polarization; Liver; Male; Membrane Fluidity; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 2000 |
Effects of peroxynitrite on rabbit cornea.
Topics: Animals; Anterior Chamber; Corneal Edema; Endothelium, Corneal; Injections; Microscopy, Electron, Scanning; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Donors; Rabbits; Superoxides; Ultrasonography | 2000 |
Potentiation of carbachol-induced Ca2+ release by peroxynitrite in human neuroblastoma SH-SY5Y cells.
Topics: Calcium; Carbachol; Genistein; Humans; Molsidomine; Neuroblastoma; Nitrates; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2000 |
Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells.
Topics: Adaptation, Physiological; Animals; Cattle; Cells, Cultured; Cystine; Dose-Response Relationship, Drug; Endothelium, Vascular; Free Radical Scavengers; Glutamic Acid; Glutathione; Metalloporphyrins; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide Donors; Nucleic Acid Synthesis Inhibitors; Penicillamine; Protein Synthesis Inhibitors; S-Nitroso-N-Acetylpenicillamine; Sodium; Superoxide Dismutase | 2000 |
cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
Topics: Animals; Cyclic GMP; Diethylamines; Drug Combinations; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Male; Molsidomine; Myocardial Contraction; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase | 2000 |
Nitric oxide inhibits isoproterenol-stimulated adipocyte lipolysis through oxidative inactivation of the beta-agonist.
Topics: 3T3 Cells; Adipocytes; Animals; Catecholamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hydrazines; Indolequinones; Indoles; Isoproterenol; Lipolysis; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxygen; Rats; Rats, Wistar; Signal Transduction; Spectrophotometry; Time Factors; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2000 |
Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage.
Topics: Antioxidants; Cell-Free System; DNA Damage; Dose-Response Relationship, Drug; Lipid Peroxides; Lipoproteins; Lipoproteins, LDL; Metallothionein; Molsidomine; Nitrates; Nitrogen; Oxygen; Plasmids; Temperature; Thiobarbituric Acid Reactive Substances; Time Factors | 2000 |
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts.
Topics: Androstadienes; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Molsidomine; Morpholines; Nitrates; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Skin; Time Factors; Tyrosine; Tyrphostins; Wortmannin | 2000 |
Effects of propofol on endothelial cells subjected to a peroxynitrite donor (SIN-1).
Topics: Anesthetics, Intravenous; Cell Culture Techniques; Cell Death; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Molsidomine; Nitrates; Nitric Oxide Donors; Propofol; Tyrosine | 2000 |
Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice.
Topics: Animals; Arthritis; Autoimmune Diseases; Catalase; Cattle; DNA Damage; Glomerulonephritis; Immunoblotting; Kidney; Liver; Mice; Mice, Inbred MRL lpr; Mice, Knockout; Molsidomine; Nitrates; Nitric Oxide Donors; omega-N-Methylarginine; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase | 2000 |
Nitration and inactivation of cytochrome P450BM-3 by peroxynitrite. Stopped-flow measurements prove ferryl intermediates.
Topics: Animals; Bacillus; Bacterial Proteins; Binding Sites; Blotting, Western; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dithiothreitol; Dose-Response Relationship, Drug; Erythrocytes; Glutathione; Inhibitory Concentration 50; Iron; Mass Spectrometry; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Molsidomine; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitric Oxide Donors; Nitrogen; Oxygen; Superoxide Dismutase; Temperature; Time Factors; Tyrosine; Uric Acid | 2000 |
Nitric oxide activation of TrkB through peroxynitrite.
Topics: 3T3 Cells; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Humans; Indole Alkaloids; Isoenzymes; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Rats; Receptor, trkB; Recombinant Proteins; Superoxide Dismutase; Transfection; Type C Phospholipases | 2000 |
Augmented death in immunostimulated astrocytes deprived of glucose: inhibition by an iron porphyrin FeTMPyP.
Topics: Animals; Astrocytes; Cell Death; Ferric Compounds; Glucose; Interferon-gamma; Membrane Potentials; Metalloporphyrins; Mitochondria; Molsidomine; Nitrates; Porphyrins; Rats; Rats, Sprague-Dawley | 2001 |
A novel procedure for generating both nitric oxide and superoxide in situ from chemical sources at any chosen mole ratio. First application: tyrosine oxidation and a comparison with preformed peroxynitrite.
Topics: Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxidants; Oxidation-Reduction; Spermine; Superoxides; Tyrosine | 2000 |
Reactive oxygen and nitrogen metabolites modulate fibronectin-induced fibroblast migration in vitro.
Topics: Blood; Cell Line; Cell Movement; Complement Activation; Deferoxamine; Dithiothreitol; Embryo, Mammalian; Fibroblasts; Fibronectins; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrogen; Reactive Oxygen Species; Reducing Agents; Superoxides; Tyrosine; Xanthine Oxidase | 2001 |
Toxicity of nitric oxide and peroxynitrite to bacterial pathogens of fish.
Topics: Aeromonas; Animals; Bacterial Infections; Catalase; Cell-Free System; Fish Diseases; Free Radical Scavengers; Microbial Sensitivity Tests; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oncorhynchus mykiss; Oxidants; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase | 2000 |
Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.
Topics: Antigens, Differentiation; Antioxidants; Apoptosis; CCAAT-Enhancer-Binding Proteins; Cell Cycle Proteins; DNA Damage; Enzyme Activation; Flow Cytometry; GADD45 Proteins; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Molsidomine; Neoplasm Proteins; Neuroblastoma; Nitrates; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proteins; Pyridines; RNA, Messenger; Signal Transduction; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured | 2001 |
Inhibition of nerve growth factor signaling by peroxynitrite.
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cell Survival; Dose-Response Relationship, Drug; Humans; MAP Kinase Signaling System; Molsidomine; Nerve Growth Factor; Neurons; Nitrates; Nitric Oxide Donors; Oxidative Stress; PC12 Cells; Rats; Receptor, trkA | 2001 |
Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36.
Topics: Animals; Arteriosclerosis; CD36 Antigens; CHO Cells; Copper; Cricetinae; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Lipid Peroxides; Lipoproteins, LDL; Membrane Proteins; Molsidomine; Nitrates; Oxidation-Reduction; Plasmodium falciparum; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B; Thiobarbituric Acid Reactive Substances; Transfection | 2001 |
Chemical evaluation of compounds as nitric oxide or peroxynitrite donors using the reactions with serotonin.
Topics: Aerobiosis; Chromatography, High Pressure Liquid; Copper; Glutathione; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; S-Nitrosoglutathione; Serotonin; Tyrosine | 2001 |
Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase).
Topics: Animals; Apoptosis; Astrocytes; Cell Survival; Cells, Cultured; Chromatin; DNA Fragmentation; Drug Interactions; Female; Glutathione; GTP-Binding Proteins; Molsidomine; Morphine; Naloxone; Narcotic Antagonists; Nitrates; Nitric Oxide Donors; Oxidants; Phosphatidylinositol 3-Kinases; Protective Agents; Rats; Rats, Sprague-Dawley | 2001 |
Cytotoxic effects of peroxynitrite, polymorphonuclear neutrophils, free-radical scavengers, inhibitors of myeloperoxidase, and inhibitors of nitric oxide synthase on bovine mammary secretory epithelial cells.
Topics: Aniline Compounds; Animals; Antioxidants; Blotting, Western; Cattle; Cell Death; Enzyme Inhibitors; Epithelial Cells; Female; Free Radical Scavengers; Histidine; L-Lactate Dehydrogenase; Lipopolysaccharides; Mammary Glands, Animal; Molsidomine; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidants; Peroxidase; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay).
Topics: Ascorbic Acid; Calcium; Catalase; Chelating Agents; Comet Assay; Data Interpretation, Statistical; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Egtazic Acid; Flow Cytometry; Humans; Kinetics; Lymphocytes; Microscopy, Ultraviolet; Molsidomine; Nitrates; Nitric Oxide Donors; Superoxide Dismutase | 2001 |
Effects of nitric oxide on normal and ischemic cochlea of the guinea pig.
Topics: Animals; Catalase; Cell Count; Cochlea; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Ischemia; Microinjections; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Nitroglycerin; Nitroso Compounds; Perilymph; S-Nitrosothiols; Sensory Receptor Cells; Superoxide Dismutase | 2001 |
A redox-based mechanism for the contractile and relaxing effects of NO in the guinea-pig gall bladder.
Topics: Acetylcholine; Animals; Arachidonic Acid; Atropine; Calcium; Gallbladder; Guinea Pigs; Male; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; Parasympatholytics; Vasodilator Agents | 2001 |
Peroxynitrite inhibits inducible (type 2) nitric oxide synthase in murine lung epithelial cells in vitro.
Topics: Animals; Base Sequence; Cell Line; DNA Primers; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Hydrazines; Lung; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; RNA, Messenger; Tyrosine | 2001 |
Hepatocellular oxidative DNA injury induced by macrophage-derived nitric oxide.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; DNA Damage; Enzyme Inhibitors; Free Radicals; Hepatocytes; In Vitro Techniques; Interferon-gamma; Lipopolysaccharides; Macrophages; Male; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Rats, Wistar; Recombinant Proteins; Superoxide Dismutase | 2001 |
Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor.
Topics: Aldehydes; Apolipoprotein A-I; Aryldialkylphosphatase; Electrophoresis, Polyacrylamide Gel; Esterases; Humans; Hydrolysis; Lipoproteins, HDL; Lysophosphatidylcholines; Molsidomine; Nitrates; Oxidation-Reduction; Phosphatidylcholines; Phospholipases A; Proteolipids; Trypsin | 2001 |
Nitrogen dioxide induces death in lung epithelial cells in a density-dependent manner.
Topics: Cell Count; Cell Death; Cells, Cultured; Culture Media, Conditioned; DNA, Single-Stranded; In Situ Nick-End Labeling; Lung; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrites; Nitrogen Dioxide; Oxidative Stress; Respiratory Mucosa | 2001 |
In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation.
Topics: Annexin A5; Apoptosis; Cells, Cultured; Child, Preschool; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; In Situ Nick-End Labeling; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stromal Cells; Superoxide Dismutase; Superoxides; T-Lymphocytes; Thymus Gland; Tyrosine | 2001 |
Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein.
Topics: Acrolein; Amidines; Animals; Antioxidants; Benzo(a)pyrene; Biotransformation; Cell Transformation, Neoplastic; Fibroblasts; Free Radicals; Lipid Peroxidation; Mice; Mice, Inbred C3H; Molsidomine; Mutagens; Nitrates; Nitric Oxide Donors; Oxidants; Oxidative Stress; Reactive Oxygen Species; Vitamin E | 2001 |
Immunostimulation of rat primary astrocytes decreases intracellular ATP level.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Central Nervous System; Dose-Response Relationship, Drug; Encephalitis; Enzyme Inhibitors; Inflammation Mediators; Interferon-gamma; Intracellular Fluid; L-Lactate Dehydrogenase; Lipopolysaccharides; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Tumor Cells, Cultured | 2001 |
Two different NO-dependent mechanisms account for the low virulence of a non-mycelial morphological mutant of Candida albicans.
Topics: Animals; Candida albicans; Candidiasis; Guanidines; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Molsidomine; Mutagenesis; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Virulence | 2001 |
Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution.
Topics: Bicarbonates; Cyclic N-Oxides; Free Radicals; Hydroxyl Radical; Lipid Bilayers; Liposomes; Mass Spectrometry; Membranes, Artificial; Molsidomine; Nitrates; Nitrosation; Oxidation-Reduction; Solutions; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spin Labels; Tyrosine; Water | 2001 |
Effects of nitric oxide and peroxynitrite on endotoxin-induced leukocyte adhesion to endothelium.
Topics: Animals; Cattle; Cell Adhesion; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Interferon-gamma; Leukocytes; Lipopolysaccharides; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Triazenes | 2001 |
Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production.
Topics: Blotting, Northern; Blotting, Western; Cell Line; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Molsidomine; Nitrates; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stress.
Topics: Biomarkers; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Molsidomine; Mutagenesis, Site-Directed; Myocardial Reperfusion Injury; Myoglobin; Nitrates; Oxidative Stress; Reactive Oxygen Species | 2001 |
Peroxynitrite causes endothelial cell monolayer barrier dysfunction.
Topics: Actins; Animals; beta Catenin; Cell Survival; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Pulmonary Artery; Reactive Oxygen Species; Superoxide Dismutase; Swine; Trans-Activators; Tyrosine | 2001 |
Role of nitric oxide in histamine release from human basophils and rat peritoneal mast cells.
Topics: Animals; Antibodies; Arginine; Basophils; Calcimycin; Dose-Response Relationship, Drug; Guanidines; Hemoglobins; Histamine; Humans; Immunoglobulin E; Male; Mast Cells; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Sodium Nitrite | 2001 |
Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants.
Topics: Acetates; Acetylcholine; Animals; Antioxidants; Biological Transport; Carbon Radioisotopes; Choline; Choline O-Acetyltransferase; Drug Interactions; Molsidomine; Nitrates; Oxidants; Reducing Agents; Torpedo; Tyrosine; Uric Acid | 2001 |
[Erectile dysfunction. Help also for cardiac patients].
Topics: Apomorphine; Contraindications; Coronary Disease; Drug Interactions; Erectile Dysfunction; Humans; Male; Molsidomine; Nitrates; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2001 |
Formation of peroxynitrite from reaction of nitroxyl anion with molecular oxygen.
Topics: Animals; Anions; Antioxidants; Cattle; Dose-Response Relationship, Drug; Hydrogen Peroxide; Hydrogen-Ion Concentration; Models, Chemical; Molsidomine; NAD; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitrogen Oxides; Oxygen; Peroxynitrous Acid; Rhodamines; Superoxide Dismutase | 2002 |
Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species.
Topics: Alginates; Apoptosis; Cell Survival; Cells, Cultured; Chondrocytes; Humans; Microspheres; Molsidomine; NAD; NADP; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroprusside; Nitroso Compounds; Oxidative Stress; Reactive Oxygen Species; Triazenes | 2002 |
Peroxynitrite scavenging activity of sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) isolated from Brassica juncea.
Topics: Brassica; Coumaric Acids; Free Radical Scavengers; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
Nitric oxide and peroxynitrite promote complete disruption of the [4Fe-4S] cluster of recombinant human iron regulatory protein 1.
Topics: Aconitate Hydratase; Blotting, Western; Conserved Sequence; Electrophoretic Mobility Shift Assay; Ferrozine; Humans; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Mercaptoethanol; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Tyrosine | 2003 |
Indirect measurement of nitric oxide production by monitoring nitrate and nitrite using microchip electrophoresis with electrochemical detection.
Topics: Electrochemistry; Electrophoresis; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Reproducibility of Results; Sensitivity and Specificity | 2002 |
Three model systems measure oxidation/nitration damage caused by peroxynitrite.
Topics: Antioxidants; DNA Damage; DNA, Superhelical; Escherichia coli; Fruit; Luciferases; Luminescent Measurements; Luminol; Molsidomine; Mutation; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Phenols; Plasmids; Solutions; Tea | 2003 |
NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis.
Topics: Animals; Arginine; Blood Pressure; Body Weight; Enzyme Inhibitors; Fibronectins; Fibrosis; Gene Expression; Glomerulonephritis; Isoantibodies; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Plasminogen Activator Inhibitor 1; Proteinuria; Rats; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Human plasminogen is highly susceptible to peroxynitrite inactivation.
Topics: Antithrombin III; Chromogenic Compounds; Data Interpretation, Statistical; Diabetes Mellitus; Drug Combinations; Enzyme Inhibitors; Fructose; Glucose; Humans; Molsidomine; Nitrates; Oxidants; Plasma; Plasminogen; Streptokinase | 2003 |
Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.
Topics: 3T3-L1 Cells; Animals; Binding Sites; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Molsidomine; Nitrates; Peroxynitrous Acid; Phosphoproteins; Protein Binding; Rats; Tyrosine | 2004 |
Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.
Topics: Animals; Blood Pressure; Hemodynamics; Hypertension; Kidney; Male; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrites; Oxidative Stress; Oxidoreductases; Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Superoxides; Tyrosine | 2005 |
Peroxynitrite-mediated matrix metalloproteinase-2 activation in human hepatic stellate cells.
Topics: Cell Line; Collagenases; Enzyme Activation; Hepatocytes; Humans; I-kappa B Proteins; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Molsidomine; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrates; Penicillamine; Peroxynitrous Acid; Phosphorylation; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2005 |
Angiotensin II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Rats; Receptor, Angiotensin, Type 1; Tyrosine | 2005 |
Nitric oxide and peroxynitrite regulate transporter transcription in rat liver slices.
Topics: Animals; Aspartate Aminotransferases; Carrier Proteins; Gadolinium; In Vitro Techniques; Interleukin-1beta; Liver; Male; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spermine; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2008 |
Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.
Topics: Animals; Antioxidants; Brain Chemistry; Cell Survival; Indicators and Reagents; Indole Alkaloids; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; PC12 Cells; Peroxynitrous Acid; Piperazines; Protective Agents; Rats; Structure-Activity Relationship; Tyrosine | 2008 |
Elevated plasma concentration of NO and cGMP may be responsible for the decreased platelet aggregation and platelet leukocyte conjugation in platelets hypo-responsive to catecholamines.
Topics: Adenosine Triphosphate; Adult; Asian People; Blood Platelets; Catecholamines; Cyclic AMP; Cyclic GMP; Female; Humans; Leukocyte Common Antigens; Leukocytes; Male; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Platelet Aggregation; Platelet Aggregation Inhibitors; Young Adult | 2009 |
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion.
Topics: Blood Platelets; Blood Proteins; Cell Adhesion; Enzyme Inhibitors; Fibrinogen; Free Radical Scavengers; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Peroxynitrous Acid; Solubility; Superoxides; Thrombin; Tyrosine | 2010 |
Refractory blood pressure in female SHR to increased oxidative stress is not mediated by NO or by upregulation of renal antioxidant enzymes.
Topics: Animals; Antioxidants; Blood Pressure; Female; Hypertension; Isoprostanes; Kidney; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Up-Regulation; Vasodilator Agents | 2010 |
Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration.
Topics: Animals; Caspase 3; Cell Count; Cell Death; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; Metalloporphyrins; Mice; Molsidomine; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Nitrates; Oxidative Stress; Oxidopamine; Porphyrins; Sympatholytics | 2010 |
A dual acting compound with latanoprost amide and nitric oxide releasing properties, shows ocular hypotensive effects in rabbits and dogs.
Topics: Amides; Animals; Antihypertensive Agents; Aorta; Bimatoprost; Chromatography, High Pressure Liquid; Cloprostenol; Dinoprost; Disease Models, Animal; Dogs; Glaucoma; Intraocular Pressure; Latanoprost; Male; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Ocular Hypertension; Prostaglandins F, Synthetic; Rabbits; Tandem Mass Spectrometry; Tonometry, Ocular; Vasodilation; Vasodilator Agents | 2011 |
[From beta blocker to relaxation exercises. Prevention of angina pectoris attacks].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Exercise Therapy; Humans; Molsidomine; Nitrates; Relaxation Therapy | 2011 |
Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.
Topics: Antioxidants; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Humans; Imidazolidines; Male; MAP Kinase Signaling System; Membrane Glycoproteins; Membrane Transport Proteins; Molsidomine; Nitrates; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroprusside; Nitrosation; RNA, Messenger; Schwann Cells; Taurine; Thioctic Acid | 2012 |