nitrates and molsidomine

nitrates has been researched along with molsidomine in 196 studies

Research

Studies (196)

TimeframeStudies, this research(%)All Research%
pre-199014 (7.14)18.7374
1990's105 (53.57)18.2507
2000's70 (35.71)29.6817
2010's7 (3.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Groszmann, RJ; Rodríguez-Pérez, F1
Schmid, M; Yeates, RA1
Dubach, P; Ratti, R1
Feelisch, M; Noack, E1
Henry, PJ; Horowitz, JD; Louis, WJ1
Förster, S; Schröder, H; Schrör, K; Woditsch, I1
Dirschinger, J; Rudolph, W2
Kober, G; Schulz, W1
Drummer, C; Gerzer, R; Heim, JM; Karrenbrock, B1
Feelisch, M; Noack, E; Ostrowski, J1
Nemirovskaia, MA; Vertkin, AL; Zharov, EI1
Alpert, JS1
Holzmann, S; Kukovetz, WR2
Gerzer, R; Grewe, R; Karrenbrock, B; Loeschke, K1
Holzmann, S; Kukovetz, WR; Romanin, C1
Gerzer, R; Heim, JM; Karrenbrock, B; Siess, W1
Bassenge, E; Stewart, DJ1
Abramowicz, M; Berkenboom, G; Degré, S; Sobolski, J; Stoupel, E; Vandermoten, P1
Dirschinger, J; Fleck, E; Rudolph, W1
Bassenge, E; Busse, R1
Bockaert, J; Culcasi, M; Gaven, F; Lafon-Cazal, M; Pietri, S1
Duran, D; Horwitz, J; Ischiropoulos, H1
Campbell, G; De Groote, MA; Fang, FC; Granger, D; Prince, R; Xu, Y1
Darley-Usmar, V; Moore, KP; Morrow, J; Roberts, LJ2
Ankarcrona, M; Bonfoco, E; Krainc, D; Lipton, SA; Nicotera, P1
Inoue, S; Kawanishi, S1
Denzer, D; Hecker, G; Wohlfeil, S1
Beckman, JS; Brunelli, L; Crow, JP1
Beckman, JS; Crow, JP; McCord, JM1
Beckman, J; Crow, JP; Haddad, IY; Hu, P; Matalon, S; Ye, Y1
Fehske, W; Honikel, HJ1
Brüne, B; Mohr, S; Stamler, JS1
Klatt, P; Mayer, B; Schmidt, K1
Berkenboom, G; de Cannière, D; Staroukine, M; Unger, P; Vachiery, JL1
Augusto, O; Gatti, RM; Radi, R1
Bode-Böger, SM; Böger, RH; Frölich, JC; Gerecke, U1
Schrör, K; Strobach, H; Weber, AA1
Chen, HS; Choi, YB; Lei, SZ; Lipton, SA; Loscalzo, J; Pan, ZH; Singel, DJ; Stamler, JS; Sucher, NJ1
Bouton, C; Drapier, JC; Raveau, M1
Darley-Usmar, V; Knowles, RG; Lizasoain, I; Moncada, S; Moro, MA1
Constantine-Paton, M; Rentería, RC1
Dickens, BF; Komarov, AM; Mak, IT; Stafford, RE; Wagner, TL; Weglicki, WB1
Elliott, SJ1
Green, CJ; Hidalgo, A; Mohammed, S; Motterlini, R; Sammut, I; Shah, KA; Srai, K1
Haddad, IY; Matalon, S; Zhu, S1
Bassenge, E; Cereda, R; Fink, B1
Boulanger, CM; Desta, B; Nakashima, M; Vanhoutte, PM1
Balazy, M; Barton, A; Bednar, MM; Bingham, J; Booth, C; Fuller, SP; Golding, L; Gross, CE; Murphy, M1
Ballmaier, D; Briviba, K; Epe, B; Roussyn, I; Sies, H1
Darley-Usmar, VM; Diczfalusy, U; Dzeletovic, S; Patel, RP; Wilson, MT1
Crews, BC; Landino, LM; Marnett, LJ; Morrow, JD; Timmons, MD1
Bassenge, E; Dikalov, S; Skatchkov, M1
Haussmann, HJ; Muller, T; Schepers, G1
Hoglen, NC; Liebler, DC; Sipes, IG; Waller, SC1
Hemmens, B; Leopold, E; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER1
Fisher, D; Ischiropoulos, H; Kang, M; Thom, SR1
Gewitz, MH; Gloster, ES; Mathew, R; Sundararajan, T; Thompson, CI; Zeballos, GA1
Holm, P; Kankaanranta, H; Knowles, RG; Kosonen, O; Moilanen, E; Vuorinen, P1
Ohshima, H; Yoshie, Y1
Asahi, M; Fujii, J; Hori, M; Kuzuya, T; Shimonishi, Y; Takao, T; Taniguchi, N1
Bouton, C; Drapier, JC; Hirling, H1
Invernizzi, P; O'Connor, M; Salzman, AL; Setchell, KD; Szabó, C; Ueta, I1
Schächinger, V; Zeiher, AM1
Blasini, R; Lehmann, G; Schömig, A1
Kondo, H; Niki, E; Takahashi, M1
Ade, P; Balduzzi, M; Guastadisegni, C; Levi, G; Minghetti, L; Nicolini, A; Polazzi, E1
Fink, MP; Menconi, MJ; Unno, N1
Janssen, YM; Matalon, S; Mossman, BT1
Anggård, EE; Carrier, MJ; Quine, LA1
Amin, N; Pearce, B1
Angaut-Petit, D; Blanchard, B; Ducrocq, C; Faille, L; Meunier, FA; Morot Gaudry-Talarmain, Y; Moulian, N1
Gow, AJ; Ischiropoulos, H; Thom, SR1
Cuthbertson, BH; Galley, HF; Webster, NR1
Christopher, TA; Ischiropoulos, H; Liu, GL; Lopez, BL; Ma, XL1
Denenberg, AG; Kennedy, M; Salzman, AL; Szabó, C1
Brandi, ML; MacIntyre, I; Mancini, L; Moradi-Bidhendi, N1
Arnal, JF; Besombes, JP; Bounhoure, JP; Fauvel, JM; Galinier, M; Mazerolles, M; Rami, J1
Blasig, IE; Davies, KJ; Grune, T; Haseloff, R; Roloff, B; Sitte, N1
de Groot, H; Kirsch, M; Lomonosova, EE; Rauen, U1
Branka, JE; Dreno, B; Jarry, A; Laboisse, CL; Sainte-Marie, I; Tenaud, I; Vallette, G1
de Groot, H; Kirsch, M; Korth, HG; Lomonosova, EE; Sustmann, R1
Davies, MJ; Stocker, R; Thomas, SR1
Maruyama, W; Naoi, M; Takahashi, T1
Hogg, N; Kalyanaraman, B; Konorev, EA1
DuVall, MD; Fuller, CM; Matalon, S; Zhu, S1
Helton, ES; Jackson, RM; Parish, G1
Bocca, AL; Campanelli, AP; Cunha, FQ; Figueiredo, F; Furlanetto, AB; Hayashi, EE; Pinheiro, AG1
Mayer, B; Pfeiffer, S1
Kim, WK; Ko, KH1
Blaylock, MG; Cuthbertson, BH; Ferguson, NR; Galley, HF; Webster, NR1
Aguirre, DE; Fink, MP; Menconi, MJ; Smith, M; Unno, N1
Asada, S; Fukuda, K; Oh, M; Tanaka, S; Yasuda, Y1
Maisch, B1
Hogg, N; Joseph, J; Kalyanaraman, B; Konorev, E; Singh, RJ1
Goss, SP; Hogg, N; Kalyanaraman, B1
Hirata, K; Kanazawa, H; Okamoto, T; Shiraishi, S; Yoshikawa, J1
Regoli, F; Winston, GW1
Niki, E; Noguchi, N; Shi, H; Xu, Y1
Roberts, LJ; van der Veen, RC1
Edelstein, CL; Gengaro, PE; Ling, H; Nemenoff, RA; Schrier, RW; Wangsiripaisan, A1
Celan, I; Chazotte, L; Mower, HF; Ohshima, H; Pignatelli, B1
Angioï, M; Bertrand, A; Branly, F; Brouant, B; Danchin, N; Grentzinger, A; Juillière, Y; Karcher, G; Marie, PY; Olivier, P; Virion, JM; Zannad, F1
Maeda, S; Saeki, M1
Grisham, MB; Koyama, S; Robbins, RA; Sato, E; Simpson, KL3
Anderson, RL; Hurley, JV; Lepore, DA; Morrison, WA; Stewart, AG; Tomasi, A1
Callahan, LA; DiMarco, A; Nethery, D; Nosek, TM; Stofan, D; Supinski, G1
de Groot, H; Kirsch, M2
Beckman, JS; Crow, JP; MacMillan-Crow, LA; Takakura, K1
Akiyama, K; Aoyagi, K; Hirayama, A; Koyama, A; Nagase, S; Narita, M; Ohba, S; Shahrzad, S; Takemura, K; Tomida, C1
Isobe, K; Maruyama, W; Naoi, M; Oh-hashi, K; Takahashi, T; Yi, H1
Deeb, RS; Hajjar, DP; Upmacis, RK1
Morioka, N; Okatani, Y; Wakatsuki, A; Watanabe, K1
Chesnais, JM; Fischmeister, R; Mery, PF1
Elstner, EF; Schneider, D1
Hirata, K; Kanazawa, H; Yoshikawa, J2
Jan, KY; Liu, F1
Packer, L; Park, YC; Rimbach, G; Virgili, F1
Hayakawa, A; Hayashi, S; Kobayashi, T; Negita, M; Ogawa, H; Takagi, H; Yokoyama, I1
Althaus, JS; Borosky, S; Carroll, RT; Galatsis, P; Hall, ED; Kopec, KK; Kumar, V1
Basiouny, KF; Crow, JP; Matalon, S; Zhu, S1
Ju, C; Kim, HC; Kim, WK; Ko, KH; Oh, YK; Ryu, JR; Shin, CY; Yoon, KN1
Meinhardt, G; Sechtem, U1
Chen, Q; Gole, M; Gow, AJ; Ischiropoulos, H; Lee, VM; Themistocleous, M1
Beukelman, CJ; Folkerts, G; Koster, AS; Muijsers, RB; Nijkamp, FP; Postma, DS; van Den Worm, E1
Choi, JH; Chung, HY; Kim, KW; Kim, MS; Lee, KH; Yang, R; Yokozawa, T1
Byrne, L; Croft, KD; Morton, LW; Puddey, IB1
Muriel, P; Sandoval, G1
Akiba, J; Hikichi, T; Kado, M; Yanagiya, N; Yoshida, A1
Kamisaki, Y; Maeda, S; Saeki, M1
Buckley, BJ; Whorton, AR1
Ekelund, UE; Georgakopoulos, D; Hare, JM; Harrison, RW; Isoda, T; Kass, DA; Ozaki, M; Paolocci, N; Vandegaer, K1
Cacho, J; Crespo, MD; Herrera, E; Klatt, P; Ramos, P1
Cai, L; Kang, YJ; Klein, JB1
Holbrook, NJ; Klotz, LO; Schieke, SM; Sies, H1
Deby-Dupont, G; Hans, P; Kohnen, S; Lamy, M; Mathy-Hartert, M; Mouithys-Mickalad, A1
Gilkeson, GS; Keng, T; Privalle, CT; Weinberg, JB1
Daiber, A; Herold, S; Namgaladze, D; Peterson, JA; Schöneich, C; Ullrich, V1
Bothwell, M; Gunther, EC; Yuen, EC1
Choi, CR; Choi, IY; Chung, JH; Kim, HC; Kim, WK; Ko, KH; Lee, SJ; Nam, W; Noh, SK; Park, JS; Shin, CY; Shin, DH1
Hodges, GR; Ingold, KU; Marwaha, J; Paul, T1
Camhi, SL; Koyama, S; Nelson, DK; Robbins, RA; Sato, E1
Campos-Pérez, JJ; Ellis, AE; Secombes, CJ1
Isobe, K; Maruyama, W; Oh-Hashi, K1
Buccafusco, JJ; Jonnala, RR1
Connelly, PW; Crandall, I; Guy, RA; Kain, KC; Maguire, GF1
Blanchard, B; Ducrocq, C; Servy, C1
Cheong, YP; Chung, YT; Kim, BR; Kim, MS; Kim, TY; Lee, KM; Oh, J; Park, R; So, HS; Son, Y1
Douglass, LW; Ledbetter, TK; Paape, MJ1
Barbouti, A; Doulias, PT; Galaris, D; Ischiropoulos, H1
Leong, SK; Ruan, RS; Yeoh, KH1
Alcón, S; Camello, PJ; Hemming, JM; Jennings, L; Mawe, GM; Morales, S; Pozo, MJ1
Camhi, SL; Hoyt, JC; Nelson, DK; Robbins, RA; Robinson, VK; Sato, E1
Ishii, H; Miura, S; Watanabe, N; Zeki, S1
Ahmed, Z; Connelly, PW; Draganov, D; Emili, A; Kuksis, A; La Du, BN; Maguire, GF; Ravandi, A1
Blay, WM; Heintz, NH; Hemenway, DR; Janssen-Heininger, YM; Persinger, RL1
Berrih-Aknin, S; Gaudry-Talarmain, YM; Moulian, N; Serraf, A; Truffault, F1
Niki, E; Noguchi, N; Satoh, K; Takabe, W; Uchida, K; Yamada, S1
Choi, JW; Kim, H; Kim, W; Ko, KH; Ryu, JH; Ryu, JR; Shin, CY1
Diez-Orejas, R; Gil, C; Molero, G; Moro, MA; Nombela, C; Sánchez-Pérez, M1
Feix, J; Hogg, N; Joseph, J; Kalyanaraman, B; Zhang, H1
Edelstein, C; Gengaro, P; Lelamali, K; Schrier, RW; Wang, W1
Créminon, C; Eligini, S; Habib, A; Lebret, M; Lévy-Toledano, S; Maclouf, J1
Douglas, DJ; Mauk, AG; Stocker, R; Witting, PK1
Gupta, MP; Hart, CM; Knepler, JL; Ober, MD; Patterson, C; Pavalko, F; Taher, LN1
Assem, EK; Moulson, A; Pearce, FL; Peh, KH; Wan, BY1
Ducrocq, C; Gaudry-Talarmain, YM; Guermonprez, L1
Del Carlo, M; Loeser, RF1
Choi, JS; Chung, HY; Kim, AR; Kim, JE; Zou, Y1
Drapier, JC; Soum, E1
Kikura-Hanajiri, R; Lunte, SM; Martin, RS1
McConnell, P; Reasor, MJ; Van Dyke, K1
Daig, U; Krämer, S; Liefeldt, L; Martini, S; Neumayer, HH; Peters, H; Rückert, M; Schäper, F1
Gugliucci, A1
Choi, JB; Igarashi, Y; Kashiwagi, A; Kawamori, R; Maegawa, H; Mineki, R; Murayama, K; Nomiyama, T; Ogihara, T; Taka, H; Tanaka, Y; Uchida, T; Uchino, H; Watada, H1
Fortepiani, LA; Reckelhoff, JF1
Abiru, S; Eguchi, K; Ishibashi, H; Komori, A; Maeda, Y; Migita, K; Nakamura, M; Takii, Y; Yatsuhashi, H; Yokoyama, T1
Bottari, SP; Garrido, MR; Levy, P; Pinzar, E; Wang, T; Xu, W1
Aoki, K; Kato, S; Saso, N; Sato, H; Sugiyama, Y1
Münzel, T1
Arai, T; Fujieda, S; Kobayashi, S; Kuramochi, K; Nakajima, M; Nakazaki, A; Ohnishi, K; Saitoh, Y; Sugawara, F; Takeuchi, T; Watanabe, N1
Kim, JM; Kim, SY; Koo, JY; Koo, YK; Oh, D; Park, S; Yun-Choi, HS1
Antunes, E; Cardoso, MH; De Nucci, G; Lilla, S; Marcondes, S; Morganti, RP; Murad, F1
Iliescu, R; Lopez-Ruiz, AF; Reckelhoff, JF1
Amit, T; Bar-Am, O; Gross, Z; Kupershmidt, L; Mahammed, A; Mandel, S; Okun, Z; Saltsman, I; Youdim, MB1
Förstermann, U; Li, H1
Batugo, M; Borghi, V; Brambilla, S; Carreiro, ST; Chiroli, V; Chong, WK; Gale, DC; Guzzetta, M; Impagnatiello, F; Krauss, AH; Ongini, E; Prasanna, G1
Neumaier, J1
Askwith, T; Eggo, MC; Stevens, MJ; Zeng, W1

Reviews

9 review(s) available for nitrates and molsidomine

ArticleYear
Pharmacologic treatment of portal hypertension.
    Gastroenterology clinics of North America, 1992, Volume: 21, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Clonidine; Gastrointestinal Hemorrhage; Humans; Hypertension, Portal; Metoclopramide; Molsidomine; Nitrates; Nitroglycerin; Serotonin Antagonists; Somatostatin; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins

1992
Clinical comparison of nitrates and sydnonimines.
    European heart journal, 1991, Volume: 12 Suppl E

    Topics: Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Heart Failure; Molsidomine; Nitrates

1991
Response of coronary arteries to nitrates, the EDRF-donor SIN-1, and calcium antagonists.
    Basic research in cardiology, 1991, Volume: 86 Suppl 2

    Topics: Calcium Channel Blockers; Coronary Vasospasm; Coronary Vessels; Humans; Molsidomine; Nitrates; Nitroglycerin; Vasodilation

1991
[Effects of antianginal agents on myocardial blood flow].
    Herz, 1982, Volume: 7, Issue:6

    Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Circulation; Humans; Molsidomine; Nitrates; Oxyfedrine; Sydnones; Vasodilator Agents

1982
[Effect of nitrates, nitrate-like substances, calcium antagonists and beta-adrenergic receptor blockers on peripheral circulation].
    Herz, 1982, Volume: 7, Issue:6

    Topics: Adrenergic beta-Antagonists; Amyl Nitrite; Angina Pectoris; Animals; Blood Circulation; Calcium Channel Blockers; Humans; Isosorbide Dinitrate; Molsidomine; Muscle Contraction; Muscles; Nitrates; Nitroglycerin; Nitroprusside; Rats; Sydnones

1982
[Nitric oxide in therapy of angina pectoris: nitrates or molsidomine?].
    Der Internist, 1997, Volume: 38, Issue:5

    Topics: Angina Pectoris; Animals; Coronary Circulation; Drug Tolerance; Humans; Molsidomine; Nitrates; Nitric Oxide; Vasodilator Agents

1997
[Nitric oxide donors in therapy of chronic heart failure].
    Der Internist, 1997, Volume: 38, Issue:5

    Topics: Chronic Disease; Drug Tolerance; Heart Failure; Hemodynamics; Humans; Molsidomine; Nitrates; Nitric Oxide; Vasodilator Agents

1997
[Recent findings on nitrates: their action, bioactivation and development of tolerance].
    Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133, Issue:44

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Coronary Disease; Drug Tolerance; Endothelium, Vascular; Guanylate Cyclase; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Oxidative Stress; Pentaerythritol Tetranitrate; Reactive Oxygen Species; Vasodilation; Vasodilator Agents

2008
[The pharmacology of nitric oxide and nitrates].
    Pharmazie in unserer Zeit, 2010, Volume: 39, Issue:5

    Topics: Animals; Humans; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Vasodilator Agents

2010

Trials

6 trial(s) available for nitrates and molsidomine

ArticleYear
[Effect of vasodilator agents on the effectiveness of the complex treatment of patients with ischemic heart disease and congestive heart failure].
    Kardiologiia, 1989, Volume: 29, Issue:4

    Topics: Aged; Cardiomyopathy, Dilated; Clinical Trials as Topic; Coronary Disease; Digoxin; Drug Synergism; Drug Therapy, Combination; Female; Furosemide; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Myocardial Contraction; Nitrates

1989
Effectiveness of molsidomine in the long-term treatment of exertional angina pectoris and chronic congestive heart failure.
    American heart journal, 1985, Volume: 109, Issue:3 Pt 2

    Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Electrocardiography; Heart Failure; Heart Rate; Humans; Molsidomine; Nitrates; Oxadiazoles; Pulmonary Artery; Sydnones; Vasodilator Agents

1985
[Hemodynamics effects of continuous infusion of molsidomine and nitrates and subsequent oral medication in therapy of acute myocardial infarct].
    Medizinische Klinik (Munich, Germany : 1983), 1994, Volume: 89 Suppl 2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Female; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Molsidomine; Myocardial Infarction; Nitrates; Nitroglycerin; Vasodilator Agents

1994
Comparison of the hemodynamic responses to molsidomine and isosorbide dinitrate in congestive heart failure.
    American heart journal, 1994, Volume: 128, Issue:3

    Topics: Biotransformation; Double-Blind Method; Drug Tolerance; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Middle Aged; Molsidomine; Nitrates; Pulmonary Wedge Pressure

1994
Nasal nitric oxide concentration is decreased in heart failure patients receiving nitrates.
    Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:1

    Topics: Adult; Aged; Female; Heart Diseases; Humans; Male; Middle Aged; Molsidomine; Nasal Cavity; Nitrates; Nitric Oxide; Respiration; Respiration, Artificial; Trachea

1998
Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite.
    Chemical research in toxicology, 1998, Volume: 11, Issue:5

    Topics: Adenosine Triphosphatases; Adult; Antioxidants; Enzyme Inhibitors; Female; Humans; Lipoproteins, LDL; Male; Mass Spectrometry; Molsidomine; Nitrates; Oxidants; Oxidation-Reduction; Plasma; Ubiquinone; Vitamin E

1998

Other Studies

181 other study(ies) available for nitrates and molsidomine

ArticleYear
Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:3

    Topics: Animals; Antioxidants; Aorta, Thoracic; Drug Tolerance; Female; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Nitrates; Nitroglycerin; Parasympatholytics; Rabbits; Vasodilator Agents

1992
[Anti-ischemia drug therapy].
    Therapeutische Umschau. Revue therapeutique, 1991, Volume: 48, Issue:8

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Fibrinolytic Agents; Humans; Molsidomine; Nitrates

1991
Molecular mechanisms of nitrovasodilator bioactivation.
    Basic research in cardiology, 1991, Volume: 86 Suppl 2

    Topics: Amyl Nitrite; Enzyme Activation; Guanylate Cyclase; Isosorbide Dinitrate; Methemoglobin; Molsidomine; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins

1991
Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity.
    Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:3

    Topics: Animals; Arteries; Cattle; Coronary Vessels; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitric Oxide; Nitroglycerin; Vasodilator Agents

1990
Reduced nitric oxide release causes nitrate tolerance in the intact coronary circulation.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:6

    Topics: Animals; Bradykinin; Cell Line; Coronary Vessels; Cyclic GMP; Drug Tolerance; Fibroblasts; Heart; Iloprost; Lung; Molsidomine; Myocardium; Nitrates; Nitric Oxide; Nitroglycerin; Rabbits; Rats; Vasodilator Agents

1991
Inhibition of platelet activating factor-induced platelet aggregation by molsidomine, SIN-1, and nitrates in vitro and ex vivo.
    Journal of cardiovascular pharmacology, 1989, Volume: 14 Suppl 11

    Topics: Cyclic GMP; Enzyme Activation; In Vitro Techniques; Molsidomine; Nitrates; Nitric Oxide; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents

1989
On the mechanism of NO release from sydnonimines.
    Journal of cardiovascular pharmacology, 1989, Volume: 14 Suppl 11

    Topics: Animals; Enzyme Activation; Guanylate Cyclase; Liver; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Oxygen Consumption; Rats; Superoxides

1989
The pharmacologic management of coronary artery disease in 1986.
    Heart & lung : the journal of critical care, 1986, Volume: 15, Issue:6

    Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Critical Care; Humans; Molsidomine; Nitrates

1986
Mode of action of nitrates with regard to vasodilatation and tolerance.
    Zeitschrift fur Kardiologie, 1986, Volume: 75 Suppl 3

    Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilation

1986
[Comparison of the effects of SIN-1, sodium nitroprusside and nitrate derivatives on the inhibition of blood platelet aggregation and activation of soluble platelet guanylate-cyclase].
    Pathologie-biologie, 1987, Volume: 35, Issue:2 Pt 2

    Topics: Blood Platelets; Ferricyanides; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Nitroprusside; Platelet Aggregation

1987
Mechanism of vasodilation by nitrates: role of cyclic GMP.
    Cardiology, 1987, Volume: 74 Suppl 1

    Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Nitrates; Nitroglycerin; Vasodilator Agents

1987
Direct comparison of the effects of nitroprusside, SIN 1, and various nitrates on platelet aggregation and soluble guanylate cyclase activity.
    Thrombosis research, 1988, Oct-01, Volume: 52, Issue:1

    Topics: Adult; Blood Platelets; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Nitrates; Nitroprusside; Platelet Aggregation; Solubility

1988
[Mechanism of the vasodilating effect and blood platelet- antiaggregating activity of molsidomine and SIN-1].
    Pathologie-biologie, 1987, Volume: 35, Issue:2 Pt 2

    Topics: Animals; Cyclic GMP; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Platelet Aggregation; Vasodilation

1987
Effects of nitrates in various vascular sections and regions.
    Zeitschrift fur Kardiologie, 1986, Volume: 75 Suppl 3

    Topics: Animals; Arteries; Arterioles; Blood Vessels; Dogs; Drug Tolerance; Hemodynamics; Molsidomine; Nitrates; Nitroglycerin; Vasodilation; Veins

1986
Comparison of the influence of nitrates, molsidomine and SIN-1, a molsidomine metabolite in acute coronary insufficiency.
    Bibliotheca cardiologica, 1985, Issue:39

    Topics: Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Ergonovine; Humans; Molsidomine; Myocardial Infarction; Nitrates; Platelet Aggregation

1985
Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells.
    Neuropharmacology, 1993, Volume: 32, Issue:11

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Catalase; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Mice; Molsidomine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Superoxides; Xanthine Oxidase

1993
Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells.
    Journal of neurochemistry, 1995, Volume: 65, Issue:5

    Topics: Animals; Dihydroxyphenylalanine; Molsidomine; Nitrates; Oxidation-Reduction; PC12 Cells; Rats; Tyrosine

1995
Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Jul-03, Volume: 92, Issue:14

    Topics: Base Sequence; DNA Primers; Genes, Bacterial; Glutathione; Microbial Sensitivity Tests; Molecular Sequence Data; Molsidomine; Mutagenesis; Nitrates; Nitric Oxide; Nitroso Compounds; Oxidation-Reduction; Polyamines; S-Nitrosoglutathione; Salmonella typhimurium; Species Specificity; Vasodilator Agents

1995
Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite.
    Circulation research, 1995, Volume: 77, Issue:2

    Topics: Antihypertensive Agents; Arachidonic Acid; Arteriosclerosis; Catalysis; Humans; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Platelet Aggregation Inhibitors; Prostaglandins F, Synthetic; Superoxide Dismutase; Superoxides; Vasodilator Agents

1995
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Aug-01, Volume: 92, Issue:16

    Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cysteine; DNA; Free Radicals; Kinetics; Molsidomine; N-Methylaspartate; Necrosis; Neurons; Nitrates; Nitric Oxide; Oxidative Stress; Rats; S-Nitrosothiols; Superoxide Dismutase; Superoxides

1995
Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide.
    FEBS letters, 1995, Aug-28, Volume: 371, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cattle; Deoxyguanosine; Deoxyribonucleotides; DNA; DNA Damage; Free Radical Scavengers; Humans; Molsidomine; Nitrates; Nitric Oxide; Oxidative Stress; Superoxides

1995
Elevation of circulating NO: its effects on hemodynamics and vascular smooth muscle cell proliferation in rats.
    Agents and actions. Supplements, 1995, Volume: 45

    Topics: Animals; Carotid Arteries; Cell Division; DNA; Fluorometry; Hemodynamics; Male; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Wistar

1995
Formation of F2-isoprostanes during the oxidation of human low density lipoprotein by peroxynitrite.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Arachidonic Acids; Dinoprost; Humans; Kinetics; Lipoproteins, LDL; Molsidomine; Nitrates; Oxidation-Reduction; Platelet Aggregation Inhibitors

1995
The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli.
    Archives of biochemistry and biophysics, 1995, Jan-10, Volume: 316, Issue:1

    Topics: Escherichia coli; Free Radicals; Hydrogen Peroxide; Molsidomine; Nitrates; Nitric Oxide; Oxyhemoglobins; Toxicity Tests

1995
Sensitivity of the essential zinc-thiolate moiety of yeast alcohol dehydrogenase to hypochlorite and peroxynitrite.
    Biochemistry, 1995, Mar-21, Volume: 34, Issue:11

    Topics: Alcohol Dehydrogenase; Cysteine; Histidine; Hydrogen Peroxide; Hypochlorous Acid; Kinetics; Molsidomine; Nitrates; Sulfhydryl Compounds; Taurine; Zinc

1995
Concurrent generation of nitric oxide and superoxide damages surfactant protein A.
    The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 1

    Topics: Humans; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Penicillamine; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Reactive Oxygen Species; Rhodamines; S-Nitroso-N-Acetylpenicillamine; Superoxides; Time Factors

1994
Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents.
    FEBS letters, 1994, Jul-18, Volume: 348, Issue:3

    Topics: Adenosine Diphosphate Ribose; Binding Sites; Borates; Dithiothreitol; Glyceraldehyde-3-Phosphate Dehydrogenases; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Sulfhydryl Compounds; Superoxide Dismutase

1994
Reaction of peroxynitrite with oxyhaemoglobin: interference with photometrical determination of nitric oxide.
    The Biochemical journal, 1994, Aug-01, Volume: 301 ( Pt 3)

    Topics: Electrochemistry; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Oxyhemoglobins; Photochemistry; Spectrophotometry; Superoxide Dismutase

1994
Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates.
    Archives of biochemistry and biophysics, 1994, Volume: 310, Issue:1

    Topics: Benzoates; Cyclic N-Oxides; Deoxyribose; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Hydroxyl Radical; Models, Chemical; Molsidomine; Nitrates; Oxidation-Reduction

1994
Long-term administration of L-arginine, L-NAME, and the exogenous NO donor molsidomine modulates urinary nitrate and cGMP excretion in rats.
    Cardiovascular research, 1994, Volume: 28, Issue:4

    Topics: Animals; Arginine; Blood Pressure; Body Weight; Cholesterol; Chromatography, Gas; Cyclic GMP; Heart; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Time Factors

1994
Direct inhibition of platelet function by organic nitrates via nitric oxide formation.
    European journal of pharmacology, 1993, Sep-15, Volume: 247, Issue:1

    Topics: Adenosine Triphosphate; Animals; Anisotropy; Blood Platelets; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Esters; Fibroblasts; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thromboxanes

1993
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.
    Nature, 1993, Aug-12, Volume: 364, Issue:6438

    Topics: Animals; Brain; Cell Death; Cells, Cultured; Cysteine; Free Radicals; Molsidomine; Neurons; Nitrates; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxidation-Reduction; Rats; Receptors, N-Methyl-D-Aspartate; S-Nitrosothiols; Superoxides

1993
Modulation of iron regulatory protein functions. Further insights into the role of nitrogen- and oxygen-derived reactive species.
    The Journal of biological chemistry, 1996, Jan-26, Volume: 271, Issue:4

    Topics: Aconitate Hydratase; Animals; Cell Line; Enzyme Inhibitors; Ferritins; Hemoglobins; Hydrogen Peroxide; Iron-Regulatory Proteins; Mice; Molsidomine; Nitrates; Reactive Oxygen Species; RNA-Binding Proteins; RNA, Messenger; Superoxide Dismutase; Superoxides

1996
Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose.
    The Biochemical journal, 1996, Mar-15, Volume: 314 ( Pt 3)

    Topics: Animals; Brain; Dithiothreitol; Electron Transport Complex IV; Glucose; Glutathione; Kinetics; Mitochondria; Molsidomine; Nitrates; Nitric Oxide; Oxygen Consumption; Rats; Submitochondrial Particles; Superoxide Dismutase

1996
Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro.
    Journal of neurobiology, 1996, Volume: 29, Issue:4

    Topics: Animals; Axons; Cells, Cultured; Cysteine; Free Radical Scavengers; Mercaptoethanol; Molsidomine; Neurites; Nitrates; Nitric Oxide; Nitrites; Nitroprusside; Nitroso Compounds; Penicillamine; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Signal Transduction; Sulfhydryl Reagents; Time Factors; Vasodilator Agents; Xenopus laevis

1996
Enhanced NO production during Mg deficiency and its role in mediating red blood cell glutathione loss.
    The American journal of physiology, 1996, Volume: 271, Issue:1 Pt 1

    Topics: Animals; Electron Spin Resonance Spectroscopy; Erythrocytes; Glutathione; Hemoglobins; Magnesium Deficiency; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Weight Gain

1996
Peroxynitrite modulates receptor-activated Ca2+ signaling in vascular endothelial cells.
    The American journal of physiology, 1996, Volume: 270, Issue:6 Pt 1

    Topics: Animals; Bradykinin; Calcium; Cattle; Cells, Cultured; Endothelium, Vascular; Inositol 1,4,5-Trisphosphate; Molsidomine; Nitrates; Nitric Oxide; Receptors, Cell Surface; Signal Transduction

1996
A precursor of the nitric oxide donor SIN-1 modulates the stress protein heme oxygenase-1 in rat liver.
    Biochemical and biophysical research communications, 1996, Aug-05, Volume: 225, Issue:1

    Topics: Animals; Blotting, Northern; Enzyme Induction; Female; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Humans; Kinetics; Liver; Molsidomine; Nitrates; Nitrites; Prodrugs; Rats; Rats, Inbred Lew; RNA, Messenger; Transcription, Genetic

1996
Nitration of surfactant protein A (SP-A) tyrosine residues results in decreased mannose binding ability.
    Archives of biochemistry and biophysics, 1996, Sep-01, Volume: 333, Issue:1

    Topics: Animals; Binding Sites; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lipid Peroxidation; Liposomes; Mannose; Molsidomine; Nitrates; Nitric Oxide; Oxidative Stress; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Superoxides; Tetranitromethane; Tyrosine

1996
Effect of ITF 296 on total effective vascular compliance in the anesthetized dog under autonomic blockade.
    Journal of cardiovascular pharmacology, 1995, Volume: 26 Suppl 4

    Topics: Anesthesia; Animals; Autonomic Nerve Block; Benzoxazines; Blood Pressure; Dogs; Female; Hemodynamics; Male; Molsidomine; Muscle Tonus; Nitrates; Nitroglycerin; Oxazines; Vascular Resistance; Vasodilator Agents

1995
The nitrate ester ITF 296 relaxes isolated canine arteries and veins.
    Journal of cardiovascular pharmacology, 1995, Volume: 26 Suppl 4

    Topics: Animals; Arteries; Benzoxazines; Dogs; Electrophysiology; Endothelium, Vascular; Female; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Oxazines; Vasodilator Agents; Veins

1995
Peroxynitrite augments fMLP-stimulated chemiluminescence by neutrophils in human whole blood.
    Journal of leukocyte biology, 1996, Volume: 60, Issue:5

    Topics: Antioxidants; Azides; Benzoquinones; Catalase; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Free Radical Scavengers; Humans; Lipoxygenase Inhibitors; Luminescent Measurements; Luminol; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrates; Nitric Oxide; omega-N-Methylarginine; Proadifen; Reactive Oxygen Species; Respiratory Burst; Sodium Azide; Superoxide Dismutase; Taurine

1996
DNA damage by peroxynitrite characterized with DNA repair enzymes.
    Nucleic acids research, 1996, Nov-01, Volume: 24, Issue:21

    Topics: Butanols; Chromatography, High Pressure Liquid; DNA; DNA Damage; DNA Repair; Endonucleases; Free Radical Scavengers; Hydroxyl Radical; Molsidomine; Nitrates; tert-Butyl Alcohol

1996
Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper.
    Journal of lipid research, 1996, Volume: 37, Issue:11

    Topics: Amidines; Butylated Hydroxytoluene; Copper; Hydroxycholesterols; Ketocholesterols; Lipoproteins, LDL; Molsidomine; Molybdenum; Myoglobin; Nitrates; Oxidation-Reduction; Superoxide Dismutase; Vitamin E

1996
Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Dec-24, Volume: 93, Issue:26

    Topics: Animals; Arachidonic Acid; Cell Line; Enzyme Activation; Glutathione Peroxidase; Kinetics; Macrophages; Metalloporphyrins; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Salicylates; Superoxides

1996
Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine.
    Biochemical and biophysical research communications, 1997, Jan-03, Volume: 230, Issue:1

    Topics: Amidines; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Molsidomine; Nitrates; Peroxides; Piperidines; Reactive Oxygen Species; Spin Labels; Superoxides; Triacetoneamine-N-Oxyl

1997
Evidence for peroxynitrite as an oxidative stress-inducing compound of aqueous cigarette smoke fractions.
    Carcinogenesis, 1997, Volume: 18, Issue:2

    Topics: 3T3 Cells; Animals; Catalase; Enzyme Induction; Gene Expression; Genes, fos; Glutathione; Guanylate Cyclase; Mice; Molsidomine; Nicotiana; Nitrates; Nitric Oxide; Oxidative Stress; Plants, Toxic; Rats; Smoke; Superoxide Dismutase

1997
Reactions of peroxynitrite with gamma-tocopherol.
    Chemical research in toxicology, 1997, Volume: 10, Issue:4

    Topics: Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Vitamin E

1997
Interference of carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions.
    Free radical biology & medicine, 1997, Volume: 22, Issue:5

    Topics: Animals; Benzoates; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Serum Albumin, Bovine; Swine; Tyrosine

1997
Release of glutathione from erythrocytes and other markers of oxidative stress in carbon monoxide poisoning.
    Journal of applied physiology (Bethesda, Md. : 1985), 1997, Volume: 82, Issue:5

    Topics: Animals; Biological Transport; Biomarkers; Blood Platelets; Carbon Monoxide Poisoning; Cytochalasin B; Enzyme Inhibitors; Erythrocyte Count; Erythrocyte Membrane; Erythrocytes; Glutathione; Glutathione Disulfide; Hexoses; Male; Molsidomine; Neutrophils; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances

1997
Role of inhibition of nitric oxide production in monocrotaline-induced pulmonary hypertension.
    Journal of applied physiology (Bethesda, Md. : 1985), 1997, Volume: 82, Issue:5

    Topics: Animals; Arterioles; Blood Pressure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Male; Molsidomine; Monocrotaline; Nitrates; Nitric Oxide; Poisons; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Weight Gain

1997
3-Morpholino-sydnonimine-induced suppression of human neutrophil degranulation is not mediated by cyclic GMP, nitric oxide or peroxynitrite: inhibition of the increase in intracellular free calcium concentration by N-morpholino-iminoacetonitrile, a metabo
    Molecular pharmacology, 1997, Volume: 51, Issue:5

    Topics: Acetonitriles; Calcium; Cell Degranulation; Cyclic GMP; Humans; Molsidomine; Morpholines; Neutrophils; Nitrates; Nitric Oxide

1997
Nitric oxide synergistically enhances DNA strand breakage induced by polyhydroxyaromatic compounds, but inhibits that induced by the Fenton reaction.
    Archives of biochemistry and biophysics, 1997, Jun-01, Volume: 342, Issue:1

    Topics: Catechols; Copper; DNA Damage; Drug Synergism; Hydrogen Peroxide; Hydroquinones; Iron; Molsidomine; Nitrates; Nitric Oxide; Plasmids; Reactive Oxygen Species

1997
The oxidation of selenocysteine is involved in the inactivation of glutathione peroxidase by nitric oxide donor.
    The Journal of biological chemistry, 1997, Aug-01, Volume: 272, Issue:31

    Topics: Amino Acid Sequence; Apoptosis; Glutathione Peroxidase; Molecular Sequence Data; Molsidomine; Nitrates; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Selenocysteine

1997
Redox modulation of iron regulatory proteins by peroxynitrite.
    The Journal of biological chemistry, 1997, Aug-08, Volume: 272, Issue:32

    Topics: Aconitate Hydratase; Animals; Cells, Cultured; Cysteine; Ferritins; Humans; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Mercaptoethanol; Mice; Models, Chemical; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger

1997
Ursodeoxycholate inhibits induction of NOS in human intestinal epithelial cells and in vivo.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 1

    Topics: Adenocarcinoma; Animals; Cell Line, Transformed; Cell Survival; Enzyme Induction; Enzyme Repression; Humans; Intestinal Mucosa; Intestinal Neoplasms; Kinetics; Lipopolysaccharides; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Synthase; Nitrites; Oxygen Consumption; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Ursodeoxycholic Acid

1997
Peroxynitrite-induced hemolysis of human erythrocytes and its inhibition by antioxidants.
    FEBS letters, 1997, Aug-18, Volume: 413, Issue:2

    Topics: Acetylcysteine; Albumins; Amidines; Antioxidants; Azoles; Catalase; Chromans; Erythrocytes; Glutathione; Hematocrit; Hemolysis; Humans; Isoindoles; Molsidomine; Nitrates; Organoselenium Compounds; Uric Acid; Vitamin E

1997
Prostaglandin E2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells.
    FEBS letters, 1997, Aug-18, Volume: 413, Issue:2

    Topics: Animals; Arachidonic Acid; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Microglia; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Penicillamine; Prostaglandin-Endoperoxide Synthases; Rats; S-Nitroso-N-Acetylpenicillamine

1997
Nitric oxide-induced hyperpermeability of human intestinal epithelial monolayers is augmented by inhibition of the amiloride-sensitive Na(+)-H+ antiport: potential role of peroxynitrous acid.
    Surgery, 1997, Volume: 122, Issue:2

    Topics: Amiloride; Cell Membrane Permeability; Colonic Neoplasms; Deferoxamine; Humans; Intestinal Mucosa; Membrane Potentials; Molsidomine; Nitrates; Nitric Oxide; Nitrous Acid; Peroxynitrous Acid; Sodium-Hydrogen Exchangers; Superoxides; Tumor Cells, Cultured

1997
Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS.
    The American journal of physiology, 1997, Volume: 273, Issue:4

    Topics: Animals; Apoptosis; Cell Line; Epithelial Cells; Genes, fos; Genes, jun; Hydrogen Peroxide; Lung; Molsidomine; Nitrates; Nitric Oxide; Penicillamine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Reactive Oxygen Species; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Spermine; Transcription, Genetic

1997
Effect of anti-oxidants on the degradation of SIN-1.
    Biochemical Society transactions, 1997, Volume: 25, Issue:3

    Topics: Antioxidants; Antipyrine; Biotransformation; Cytochrome c Group; Hydrogen Peroxide; Kinetics; Molsidomine; Nitrates; Oxidation-Reduction; Superoxide Dismutase

1997
Peroxynitrite-induced toxicity in cultured astrocytes.
    Brain research, 1997, Oct-31, Volume: 773, Issue:1-2

    Topics: Animals; Animals, Newborn; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Glutathione; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Molsidomine; Nitrates; Nitric Oxide; Nitroso Compounds; Oxidants; Rats; S-Nitrosoglutathione; Superoxides

1997
Nitric oxide and peroxynitrite affect differently acetylcholine release, choline acetyltransferase activity, synthesis, and compartmentation of newly formed acetylcholine in Torpedo marmorata synaptosomes.
    Nitric oxide : biology and chemistry, 1997, Volume: 1, Issue:4

    Topics: Acetylcholine; Animals; Calcimycin; Cell Compartmentation; Choline O-Acetyltransferase; Electric Organ; Enzyme Inhibitors; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Potassium Chloride; Synaptosomes; Torpedo

1997
Nitric oxide and peroxynitrite-mediated pulmonary cell death.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Acetylcysteine; Animals; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Epithelial Cells; Kinetics; Lung; Male; Molsidomine; Nitrates; Nitric Oxide; Nitrogen Oxides; Oxidants; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Spermine

1998
The effects of nitric oxide and peroxynitrite on interleukin-8 and elastase from lipopolysaccharide-stimulated whole blood.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:2

    Topics: Free Radical Scavengers; Humans; In Vitro Techniques; Interleukin-8; Leukocyte Elastase; Lipopolysaccharides; Male; Molsidomine; Nitrates; Nitric Oxide; Triazoles

1998
Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart.
    Cardiovascular research, 1997, Volume: 36, Issue:2

    Topics: Animals; Creatine Kinase; Glutathione; L-Lactate Dehydrogenase; Male; Molsidomine; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Perfusion; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasodilator Agents

1997
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells.
    Gastroenterology, 1998, Volume: 114, Issue:3

    Topics: Adenosine Triphosphate; Caco-2 Cells; DNA Damage; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Molsidomine; Nitrates; Nitric Oxide; Penicillamine; Permeability; Poly(ADP-ribose) Polymerases; S-Nitroso-N-Acetylpenicillamine

1998
Nitric oxide superoxide and peroxynitrite modulate osteoclast activity.
    Biochemical and biophysical research communications, 1998, Feb-24, Volume: 243, Issue:3

    Topics: Animals; Animals, Newborn; Bone Resorption; Calcium; Catalase; Cells, Cultured; Cyclic GMP; Enzyme Activation; Hydrogen Peroxide; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Osteoclasts; Rats; Rats, Sprague-Dawley; Superoxides; Thionucleotides

1998
Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome.
    The Journal of biological chemistry, 1998, May-01, Volume: 273, Issue:18

    Topics: Aconitate Hydratase; Cysteine Endopeptidases; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Hydrolysis; Molsidomine; Multienzyme Complexes; Nitrates; Oxidative Stress; Proteasome Endopeptidase Complex; Tumor Cells, Cultured

1998
The critical role of Hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide.
    Free radical biology & medicine, 1998, Mar-01, Volume: 24, Issue:4

    Topics: Animals; Buffers; Catalase; Cell Death; Cell Line; Fibroblasts; HEPES; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Mice; Molsidomine; Nitrates

1998
Control of growth and differentiation of normal human epithelial cells through the manipulation of reactive nitrogen species.
    The Biochemical journal, 1998, May-01, Volume: 331 ( Pt 3)

    Topics: Catalase; Cell Differentiation; Cell Division; Cyclic N-Oxides; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; Hydrazines; Imidazoles; Keratinocytes; Molsidomine; Nitrates; Nitric Oxide; Superoxide Dismutase; Thymidine

1998
Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.
    The Journal of biological chemistry, 1998, May-22, Volume: 273, Issue:21

    Topics: Amines; Animals; Bicarbonates; Carbon Dioxide; Cattle; HEPES; Hydrogen Peroxide; Molsidomine; Nitrates; Oxygen; Superoxide Dismutase; Tryptophan

1998
(-)-Deprenyl protects human dopaminergic neuroblastoma SH-SY5Y cells from apoptosis induced by peroxynitrite and nitric oxide.
    Journal of neurochemistry, 1998, Volume: 70, Issue:6

    Topics: Antiparkinson Agents; Apoptosis; DNA Damage; Dopamine; Electrophoresis, Agar Gel; Humans; Molsidomine; Monoamine Oxidase Inhibitors; Neuroblastoma; Nitrates; Nitric Oxide; Oxidants; Pyridines; Selegiline; Tumor Cells, Cultured

1998
Rapid and irreversible inhibition of creatine kinase by peroxynitrite.
    FEBS letters, 1998, May-08, Volume: 427, Issue:2

    Topics: Acetonitriles; Animals; Creatine Kinase; Enzyme Activation; Enzyme Inhibitors; Enzyme Reactivators; Glutathione; Glutathione Disulfide; Kinetics; Molsidomine; Morpholines; Nitrates; Nitric Oxide; Oxidants; Rabbits; Sulfhydryl Compounds; Superoxides

1998
Peroxynitrite inhibits amiloride-sensitive Na+ currents in Xenopus oocytes expressing alpha beta gamma-rENaC.
    The American journal of physiology, 1998, Volume: 274, Issue:5

    Topics: Amiloride; Animals; Calcium; Electric Conductivity; Epithelial Sodium Channels; Female; Molsidomine; Nitrates; Oocytes; Oxidants; Rats; Sodium; Sodium Channels; Tetranitromethane; Xenopus laevis

1998
Peroxynitrite modulates MnSOD gene expression in lung epithelial cells.
    Free radical biology & medicine, 1998, Volume: 25, Issue:4-5

    Topics: Animals; Blotting, Northern; Cell Line; Epithelial Cells; Gene Expression; Humans; Hydrogen Peroxide; Luciferases; Lung; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Rats; Recombinant Fusion Proteins; RNA, Messenger; Superoxide Dismutase

1998
Treatment of Paracoccidioides brasiliensis-infected mice with a nitric oxide inhibitor prevents the failure of cell-mediated immune response.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Sep-15, Volume: 161, Issue:6

    Topics: Animals; Cell-Free System; Drug Administration Schedule; Immunity, Cellular; Injections, Intraperitoneal; Lung; Lung Diseases, Parasitic; Lymphocyte Activation; Macrophages, Alveolar; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroarginine; Paracoccidioides; Paracoccidioidomycosis; Penicillamine; Spleen; Tumor Necrosis Factor-alpha

1998
Lack of tyrosine nitration by peroxynitrite generated at physiological pH.
    The Journal of biological chemistry, 1998, Oct-16, Volume: 273, Issue:42

    Topics: Carbon Dioxide; Free Radicals; Hydrogen-Ion Concentration; Models, Chemical; Molsidomine; Nitrates; Nitrogen Oxides; Spermine; Tyrosine; Xanthine Oxidase

1998
Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia.
    Journal of neuroscience research, 1998, Oct-01, Volume: 54, Issue:1

    Topics: Animals; Apoptosis; Catalase; Cerebellum; Coculture Techniques; DNA Fragmentation; In Situ Nick-End Labeling; Interferon-gamma; L-Lactate Dehydrogenase; Lipopolysaccharides; Mice; Microglia; Molsidomine; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase

1998
The effect of nitric oxide and peroxynitrite on apoptosis in human polymorphonuclear leukocytes.
    Free radical biology & medicine, 1998, Volume: 25, Issue:6

    Topics: Annexin A5; Apoptosis; Flow Cytometry; Humans; Lipopolysaccharides; Lung; Molsidomine; Neutrophils; Nitrates; Nitric Oxide; Triazoles

1998
Nitric oxide donor-induced hyperpermeability of cultured intestinal epithelial monolayers: role of superoxide radical, hydroxyl radical, and peroxynitrite.
    Biochimica et biophysica acta, 1998, Sep-16, Volume: 1425, Issue:1

    Topics: Antioxidants; Caco-2 Cells; Epithelial Cells; Free Radical Scavengers; Glutathione; Humans; Hydroxyl Radical; Intestinal Absorption; Intestines; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Permeability; Superoxide Dismutase; Superoxides

1998
Concurrent generation of nitric oxide and superoxide inhibits proteoglycan synthesis in bovine articular chondrocytes: involvement of peroxynitrite.
    The Journal of rheumatology, 1998, Volume: 25, Issue:11

    Topics: Animals; Cartilage, Articular; Cattle; Chondrocytes; Immunohistochemistry; Interleukin-1; Molsidomine; Nitrates; Nitric Oxide; Proteoglycans; Superoxides

1998
[Therapy recommendations for adverse effects of Viagra and nitrates (NO-donors)].
    Herz, 1998, Volume: 23, Issue:7

    Topics: Angina Pectoris; Blood Pressure; Contraindications; Drug Therapy, Combination; Erectile Dysfunction; Humans; Male; Molsidomine; Nicorandil; Nitrates; Nitric Oxide Donors; Piperazines; Purines; Sildenafil Citrate; Sulfones

1998
The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors.
    Archives of biochemistry and biophysics, 1999, Jan-15, Volume: 361, Issue:2

    Topics: Animals; Cyclic N-Oxides; Free Radical Scavengers; Hemeproteins; Humans; Imidazoles; Kidney; Liver; Molsidomine; Myocardium; Nitrates; Nitric Oxide Donors; Oxidants; Rats

1999
The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite.
    Archives of biochemistry and biophysics, 1999, Mar-15, Volume: 363, Issue:2

    Topics: Chelating Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Liposomes; Molsidomine; Nitrates; Oxidants; Pentetic Acid; Stereoisomerism; Tyrosine; Vitamin E

1999
Inhibition of bronchoprotective effects of beta2-adrenoceptor agonists by peroxynitrite in guinea pig airways.
    American journal of respiratory and critical care medicine, 1999, Volume: 159, Issue:4 Pt 1

    Topics: Acetylcholine; Adrenergic beta-Agonists; Airway Resistance; Albuterol; Animals; Bronchoconstriction; Colforsin; Guinea Pigs; Isoproterenol; Male; Molsidomine; Nitrates; Penicillamine; Receptors, Adrenergic, beta-1

1999
Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals.
    Toxicology and applied pharmacology, 1999, Apr-15, Volume: 156, Issue:2

    Topics: Amidines; Antioxidants; Ascorbic Acid; Chromatography, Gas; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Methionine; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Oxidation-Reduction; Peroxides

1999
Formation of phospholipid hydroperoxides and its inhibition by alpha-tocopherol in rat brain synaptosomes induced by peroxynitrite.
    Biochemical and biophysical research communications, 1999, Apr-21, Volume: 257, Issue:3

    Topics: Acetophenones; Animals; Antioxidants; Brain; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Molsidomine; Nitrates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Phospholipids; Rats; Rats, Wistar; Superoxide Dismutase; Synaptosomes; Time Factors; Vitamin E

1999
Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids.
    Journal of neuroimmunology, 1999, Mar-01, Volume: 95, Issue:1-2

    Topics: Animals; Central Nervous System; Dinoprost; Encephalomyelitis, Autoimmune, Experimental; F2-Isoprostanes; Lipid Peroxidation; Mice; Molsidomine; Myelin Proteins; Myelin Sheath; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Penicillamine

1999
Effect of nitric oxide donors on renal tubular epithelial cell-matrix adhesion.
    Kidney international, 1999, Volume: 55, Issue:6

    Topics: Animals; Cell Adhesion; Cell Line; Chlorocebus aethiops; Collagen; Epithelial Cells; Fibronectins; Free Radical Scavengers; Kidney Tubules; LLC-PK1 Cells; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Opossums; Superoxides; Swine

1999
Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a postseparation, on-line reduction column and electrochemical detection: results with various nitrating agents.
    Nitric oxide : biology and chemistry, 1999, Volume: 3, Issue:2

    Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hypochlorous Acid; Indicators and Reagents; Molsidomine; Nitrates; Nitrites; Nitrogen Oxides; Serum Albumin, Bovine; Sodium Nitrite; Spectrophotometry, Ultraviolet; Spermine; Tyrosine

1999
Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging: evidence of a protective effect of beta-blocking antianginal medications.
    Journal of the American College of Cardiology, 1999, Volume: 34, Issue:1

    Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Exercise Test; Female; Humans; Male; Middle Aged; Molsidomine; Myocardial Ischemia; Nitrates; Prognosis; Regression Analysis; Retrospective Studies; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Vasodilator Agents

1999
p130cas is a cellular target protein for tyrosine nitration induced by peroxynitrite.
    Neuroscience research, 1999, Volume: 33, Issue:4

    Topics: Crk-Associated Substrate Protein; Humans; Molsidomine; Neuroblastoma; Nitrates; Nitric Oxide Donors; Oxidants; Phosphoproteins; Phosphorylation; Proteins; Retinoblastoma-Like Protein p130; Tumor Cells, Cultured; Tyrosine

1999
Effects of reactive oxygen and nitrogen metabolites on RANTES- and IL-5-induced eosinophil chemotactic activity in vitro.
    The American journal of pathology, 1999, Volume: 155, Issue:2

    Topics: Chemokine CCL5; Chemotaxis; Deferoxamine; Dithiothreitol; Dose-Response Relationship, Drug; Eosinophils; Humans; Hydrazines; Interleukin-5; Leukotriene B4; Molsidomine; Nitrates; Nitric Oxide; Nitrogen; Pteridines; Reactive Oxygen Species; Superoxides; Tyrosine; Xanthine

1999
The survival of skeletal muscle myoblasts in vitro is sensitive to a donor of nitric oxide and superoxide, SIN-1, but not to nitric oxide or peroxynitrite alone.
    Nitric oxide : biology and chemistry, 1999, Volume: 3, Issue:4

    Topics: Animals; Cell Line; Cell Survival; Molsidomine; Muscle, Skeletal; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxyhemoglobins; Rats; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine Oxidase

1999
Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:2

    Topics: Aldehydes; Animals; Calcium; Diaphragm; Kinetics; Lipid Peroxidation; Molsidomine; Muscle Contraction; Nitrates; Nitric Oxide Donors; Rats; Thiobarbituric Acid Reactive Substances

1999
Reaction of peroxynitrite with reduced nicotinamide nucleotides, the formation of hydrogen peroxide.
    The Journal of biological chemistry, 1999, Aug-27, Volume: 274, Issue:35

    Topics: Free Radical Scavengers; Free Radicals; Glutathione; Hydrogen Peroxide; Molsidomine; NAD; NADP; Nitrates; Superoxides

1999
Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite.
    Archives of biochemistry and biophysics, 1999, Sep-15, Volume: 369, Issue:2

    Topics: Aniline Compounds; Anions; Dithiothreitol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Leukocyte Common Antigens; Models, Molecular; Molsidomine; Nitrates; Nitric Oxide; Nitroso Compounds; Organophosphates; Organophosphorus Compounds; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; S-Nitrosoglutathione; Superoxide Dismutase; Tyrosine

1999
Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals.
    Free radical research, 1999, Volume: 31, Issue:1

    Topics: Argininosuccinic Acid; Benzoates; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Feedback; Free Radical Scavengers; Free Radicals; Guanidines; Hydrazines; Hydroxyl Radical; Imidazoles; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Succinates; Superoxide Dismutase

1999
Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.
    Biochemical and biophysical research communications, 1999, Sep-24, Volume: 263, Issue:2

    Topics: Antioxidants; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Caspases; DNA Fragmentation; Dopamine; Enzyme Activation; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Molsidomine; Neuroblastoma; Neurodegenerative Diseases; Neurons; Nitrates; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Superoxides; Tumor Cells, Cultured

1999
Regulation of prostaglandin H2 synthase activity by nitrogen oxides.
    Biochemistry, 1999, Sep-21, Volume: 38, Issue:38

    Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cells, Cultured; Cyclooxygenase 1; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Hydrazines; Isoenzymes; Male; Membrane Proteins; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Penicillamine; Peroxides; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Rats; S-Nitroso-N-Acetylpenicillamine; Sheep; Superoxides

1999
Melatonin inhibits the vasorelaxant action of peroxynitrite in human umbilical artery.
    Journal of pineal research, 1999, Volume: 27, Issue:2

    Topics: Antioxidants; Female; Free Radical Scavengers; Humans; In Vitro Techniques; Melatonin; Molsidomine; Nitrates; Nitric Oxide Donors; Pre-Eclampsia; Pregnancy; Umbilical Arteries; Vasodilation

1999
Peroxynitrite is a positive inotropic agent in atrial and ventricular fibres of the frog heart.
    The Journal of physiology, 1999, Dec-01, Volume: 521 Pt 2

    Topics: Aminoquinolines; Animals; Atrial Function; Catalase; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Heart Ventricles; Hydroxyl Radical; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide Donors; Oxadiazoles; Oxidants; Quinoxalines; Rana esculenta; Sodium; Sodium-Calcium Exchanger; Ventricular Function

1999
Enhancement by glucose of low density lipoprotein-oxidation by peroxynitrite.
    Zeitschrift fur Naturforschung. C, Journal of biosciences, 1999, Volume: 54, Issue:11

    Topics: Glucose; Humans; Kinetics; Lipoproteins, LDL; Male; Mannitol; Middle Aged; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Oxidation-Reduction

1999
Administration of SIN-1 induces guinea pig airway hyperresponsiveness through inactivation of airway neutral endopeptidase.
    International archives of allergy and immunology, 1999, Volume: 120, Issue:4

    Topics: Animals; Bronchial Hyperreactivity; Bronchoconstriction; Endothelin-1; Enzyme Activation; Glycopeptides; Guinea Pigs; Male; Molsidomine; Neprilysin; Nitrates; Oxidants; Protease Inhibitors; Respiratory System; Substance P; Trachea; Vasodilator Agents

1999
DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells.
    Free radical biology & medicine, 2000, Jan-01, Volume: 28, Issue:1

    Topics: Amitrole; Animals; Antioxidants; Aorta; Arsenites; Bacterial Proteins; Cadmium Chloride; Catalase; Cattle; Cells, Cultured; Chromans; Citrulline; Ditiocarb; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Endothelium, Vascular; Enzyme Inhibitors; Escherichia coli Proteins; Free Radical Scavengers; Hydrogen Peroxide; Molsidomine; Mutagens; N-Glycosyl Hydrolases; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Onium Compounds; Phenanthrolines; Reactive Oxygen Species; Sodium Compounds; Sodium Selenite; Superoxide Dismutase; Superoxides; Thiomalates; Thiourea; Uric Acid

2000
Effect of procyanidins from Pinus maritima on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages.
    Redox report : communications in free radical research, 1999, Volume: 4, Issue:4

    Topics: Animals; Biflavonoids; Catechin; Cell Line; Cells, Cultured; Endothelium, Vascular; Glutathione; Humans; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Plant Extracts; Proanthocyanidins; Trees

1999
Possible mechanism of bronchoprotection by SIN-1 in anaesthetized guinea pigs: roles of nitric oxide and peroxynitrite.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2000, Volume: 30, Issue:3

    Topics: Acetylcholine; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Dose-Response Relationship, Drug; Glutathione; Guinea Pigs; Male; Molsidomine; Nebulizers and Vaporizers; Nitrates; Nitric Oxide; Penicillamine; Rhodamines; Time Factors; Vasodilator Agents

2000
Inhibition of MIP-1alpha-induced human neutrophil and monocyte chemotactic activity by reactive oxygen and nitrogen metabolites.
    The Journal of laboratory and clinical medicine, 2000, Volume: 135, Issue:2

    Topics: Chemokine CCL3; Chemokine CCL4; Chemotaxis, Leukocyte; Complement System Proteins; Deferoxamine; Humans; Hydrazines; In Vitro Techniques; Leukotriene B4; Macrophage Inflammatory Proteins; Molsidomine; Monocytes; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants

2000
Free radicals and apoptosis of the endothelial cells.
    Transplantation proceedings, 2000, Volume: 32, Issue:1

    Topics: Animals; Aorta; Apoptosis; Caspase 3; Caspases; DNA Fragmentation; Endothelium, Vascular; Free Radicals; Mice; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Swine

2000
Reactive nitrogen and oxygen species attenuate interleukin- 8-induced neutrophil chemotactic activity in vitro.
    The Journal of biological chemistry, 2000, Apr-14, Volume: 275, Issue:15

    Topics: Chemotaxis, Leukocyte; Humans; Interleukin-8; Leukotriene B4; Molsidomine; Neutrophils; Nitrates; Nitric Oxide Donors; Tyrosine

2000
4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration.
    Chemical research in toxicology, 2000, Volume: 13, Issue:4

    Topics: Animals; Antioxidants; Cyclic N-Oxides; Hydrogen-Ion Concentration; Hydroxylation; L-Lactate Dehydrogenase; Molsidomine; Nitrates; Nitro Compounds; Nitroso Compounds; PC12 Cells; Phenol; Rats; Spin Labels

2000
Carbon dioxide enhances nitration of surfactant protein A by activated alveolar macrophages.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:5

    Topics: Carbon Dioxide; Cells, Cultured; Enzyme Activation; Epithelial Cells; Humans; Hypercapnia; Lipid Metabolism; Lipopolysaccharides; Macrophages, Alveolar; Mass Spectrometry; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Respiratory Distress Syndrome; Tyrosine

2000
Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: correlation with mitochondrial dysfunction and subsequent cell death.
    Journal of neurochemistry, 2000, Volume: 74, Issue:5

    Topics: Animals; Astrocytes; Cell Survival; Drug Synergism; Glucose; Glutathione; Membrane Potentials; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Donors; Nitroso Compounds; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione

2000
[Development of nitrate tolerance].
    Deutsche medizinische Wochenschrift (1946), 2000, Apr-20, Volume: 125 Suppl 1

    Topics: Angina Pectoris; Animals; Drug Tolerance; Humans; Molsidomine; Nitrates; Vasodilator Agents

2000
Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.
    American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:6

    Topics: Acetylcysteine; Animals; Cell Death; Cell Differentiation; Cell Line; Cell Survival; Cyclic GMP; Hydrazines; Molsidomine; Necrosis; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Sulfhydryl Compounds

2000
Apocynin inhibits peroxynitrite formation by murine macrophages.
    British journal of pharmacology, 2000, Volume: 130, Issue:4

    Topics: Acetophenones; Acridines; Animals; Antioxidants; Cell Line; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Interferon-gamma; Lipopolysaccharides; Luminescent Measurements; Macrophages; Mice; Molsidomine; Nitrates; Nitric Oxide Synthase; Oxidation-Reduction; Rhodamines

2000
The mechanism of nitric oxide and/or superoxide cytotoxicity in endothelial cells.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:3

    Topics: Animals; Catalase; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Glutathione; Hemoglobins; Hydrogen Peroxide; Maleates; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Pyrogallol; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides

2000
Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro.
    Redox report : communications in free radical research, 2000, Volume: 5, Issue:2-3

    Topics: Caffeic Acids; Coumaric Acids; Humans; Kinetics; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide Donors; Oxidants; Vitamin E

2000
Nitric oxide and peroxynitrite anion modulate liver plasma membrane fluidity and Na(+)/K(+)-ATPase activity.
    Nitric oxide : biology and chemistry, 2000, Volume: 4, Issue:4

    Topics: Animals; Cell Fractionation; Cell Polarity; Enzyme Activation; Fluorescence Polarization; Liver; Male; Membrane Fluidity; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase

2000
Effects of peroxynitrite on rabbit cornea.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:7

    Topics: Animals; Anterior Chamber; Corneal Edema; Endothelium, Corneal; Injections; Microscopy, Electron, Scanning; Mitochondria; Molsidomine; Nitrates; Nitric Oxide Donors; Rabbits; Superoxides; Ultrasonography

2000
Potentiation of carbachol-induced Ca2+ release by peroxynitrite in human neuroblastoma SH-SY5Y cells.
    Neurochemical research, 2000, Volume: 25, Issue:7

    Topics: Calcium; Carbachol; Genistein; Humans; Molsidomine; Neuroblastoma; Nitrates; Phosphorylation; Tumor Cells, Cultured; Tyrosine

2000
Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells.
    American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:4

    Topics: Adaptation, Physiological; Animals; Cattle; Cells, Cultured; Cystine; Dose-Response Relationship, Drug; Endothelium, Vascular; Free Radical Scavengers; Glutamic Acid; Glutathione; Metalloporphyrins; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide Donors; Nucleic Acid Synthesis Inhibitors; Penicillamine; Protein Synthesis Inhibitors; S-Nitroso-N-Acetylpenicillamine; Sodium; Superoxide Dismutase

2000
cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:4

    Topics: Animals; Cyclic GMP; Diethylamines; Drug Combinations; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Male; Molsidomine; Myocardial Contraction; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase

2000
Nitric oxide inhibits isoproterenol-stimulated adipocyte lipolysis through oxidative inactivation of the beta-agonist.
    The Biochemical journal, 2000, Oct-15, Volume: 351 Pt 2

    Topics: 3T3 Cells; Adipocytes; Animals; Catecholamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hydrazines; Indolequinones; Indoles; Isoproterenol; Lipolysis; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxygen; Rats; Rats, Wistar; Signal Transduction; Spectrophotometry; Time Factors; Tumor Necrosis Factor-alpha; Ultraviolet Rays

2000
Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Antioxidants; Cell-Free System; DNA Damage; Dose-Response Relationship, Drug; Lipid Peroxides; Lipoproteins; Lipoproteins, LDL; Metallothionein; Molsidomine; Nitrates; Nitrogen; Oxygen; Plasmids; Temperature; Thiobarbituric Acid Reactive Substances; Time Factors

2000
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts.
    The Biochemical journal, 2000, Nov-15, Volume: 352 Pt 1

    Topics: Androstadienes; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Molsidomine; Morpholines; Nitrates; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Skin; Time Factors; Tyrosine; Tyrphostins; Wortmannin

2000
Effects of propofol on endothelial cells subjected to a peroxynitrite donor (SIN-1).
    Anaesthesia, 2000, Volume: 55, Issue:11

    Topics: Anesthetics, Intravenous; Cell Culture Techniques; Cell Death; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Molsidomine; Nitrates; Nitric Oxide Donors; Propofol; Tyrosine

2000
Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice.
    Molecular medicine (Cambridge, Mass.), 2000, Volume: 6, Issue:9

    Topics: Animals; Arthritis; Autoimmune Diseases; Catalase; Cattle; DNA Damage; Glomerulonephritis; Immunoblotting; Kidney; Liver; Mice; Mice, Inbred MRL lpr; Mice, Knockout; Molsidomine; Nitrates; Nitric Oxide Donors; omega-N-Methylarginine; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase

2000
Nitration and inactivation of cytochrome P450BM-3 by peroxynitrite. Stopped-flow measurements prove ferryl intermediates.
    European journal of biochemistry, 2000, Volume: 267, Issue:23

    Topics: Animals; Bacillus; Bacterial Proteins; Binding Sites; Blotting, Western; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dithiothreitol; Dose-Response Relationship, Drug; Erythrocytes; Glutathione; Inhibitory Concentration 50; Iron; Mass Spectrometry; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Molsidomine; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitric Oxide Donors; Nitrogen; Oxygen; Superoxide Dismutase; Temperature; Time Factors; Tyrosine; Uric Acid

2000
Nitric oxide activation of TrkB through peroxynitrite.
    Neuroreport, 2000, Nov-09, Volume: 11, Issue:16

    Topics: 3T3 Cells; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Humans; Indole Alkaloids; Isoenzymes; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Rats; Receptor, trkB; Recombinant Proteins; Superoxide Dismutase; Transfection; Type C Phospholipases

2000
Augmented death in immunostimulated astrocytes deprived of glucose: inhibition by an iron porphyrin FeTMPyP.
    Journal of neuroimmunology, 2001, Jan-01, Volume: 112, Issue:1-2

    Topics: Animals; Astrocytes; Cell Death; Ferric Compounds; Glucose; Interferon-gamma; Membrane Potentials; Metalloporphyrins; Mitochondria; Molsidomine; Nitrates; Porphyrins; Rats; Rats, Sprague-Dawley

2001
A novel procedure for generating both nitric oxide and superoxide in situ from chemical sources at any chosen mole ratio. First application: tyrosine oxidation and a comparison with preformed peroxynitrite.
    Chemical research in toxicology, 2000, Volume: 13, Issue:12

    Topics: Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxidants; Oxidation-Reduction; Spermine; Superoxides; Tyrosine

2000
Reactive oxygen and nitrogen metabolites modulate fibronectin-induced fibroblast migration in vitro.
    Free radical biology & medicine, 2001, Jan-01, Volume: 30, Issue:1

    Topics: Blood; Cell Line; Cell Movement; Complement Activation; Deferoxamine; Dithiothreitol; Embryo, Mammalian; Fibroblasts; Fibronectins; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrogen; Reactive Oxygen Species; Reducing Agents; Superoxides; Tyrosine; Xanthine Oxidase

2001
Toxicity of nitric oxide and peroxynitrite to bacterial pathogens of fish.
    Diseases of aquatic organisms, 2000, Nov-14, Volume: 43, Issue:2

    Topics: Aeromonas; Animals; Bacterial Infections; Catalase; Cell-Free System; Fish Diseases; Free Radical Scavengers; Microbial Sensitivity Tests; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oncorhynchus mykiss; Oxidants; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase

2000
Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.
    Free radical biology & medicine, 2001, Jan-15, Volume: 30, Issue:2

    Topics: Antigens, Differentiation; Antioxidants; Apoptosis; CCAAT-Enhancer-Binding Proteins; Cell Cycle Proteins; DNA Damage; Enzyme Activation; Flow Cytometry; GADD45 Proteins; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Molsidomine; Neoplasm Proteins; Neuroblastoma; Nitrates; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proteins; Pyridines; RNA, Messenger; Signal Transduction; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured

2001
Inhibition of nerve growth factor signaling by peroxynitrite.
    Journal of neuroscience research, 2001, Jan-01, Volume: 63, Issue:1

    Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cell Survival; Dose-Response Relationship, Drug; Humans; MAP Kinase Signaling System; Molsidomine; Nerve Growth Factor; Neurons; Nitrates; Nitric Oxide Donors; Oxidative Stress; PC12 Cells; Rats; Receptor, trkA

2001
Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36.
    Atherosclerosis, 2001, Volume: 155, Issue:1

    Topics: Animals; Arteriosclerosis; CD36 Antigens; CHO Cells; Copper; Cricetinae; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Lipid Peroxides; Lipoproteins, LDL; Membrane Proteins; Molsidomine; Nitrates; Oxidation-Reduction; Plasmodium falciparum; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B; Thiobarbituric Acid Reactive Substances; Transfection

2001
Chemical evaluation of compounds as nitric oxide or peroxynitrite donors using the reactions with serotonin.
    Free radical research, 2001, Volume: 34, Issue:2

    Topics: Aerobiosis; Chromatography, High Pressure Liquid; Copper; Glutathione; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; S-Nitrosoglutathione; Serotonin; Tyrosine

2001
Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase).
    Biochemical pharmacology, 2001, Apr-01, Volume: 61, Issue:7

    Topics: Animals; Apoptosis; Astrocytes; Cell Survival; Cells, Cultured; Chromatin; DNA Fragmentation; Drug Interactions; Female; Glutathione; GTP-Binding Proteins; Molsidomine; Morphine; Naloxone; Narcotic Antagonists; Nitrates; Nitric Oxide Donors; Oxidants; Phosphatidylinositol 3-Kinases; Protective Agents; Rats; Rats, Sprague-Dawley

2001
Cytotoxic effects of peroxynitrite, polymorphonuclear neutrophils, free-radical scavengers, inhibitors of myeloperoxidase, and inhibitors of nitric oxide synthase on bovine mammary secretory epithelial cells.
    American journal of veterinary research, 2001, Volume: 62, Issue:3

    Topics: Aniline Compounds; Animals; Antioxidants; Blotting, Western; Cattle; Cell Death; Enzyme Inhibitors; Epithelial Cells; Female; Free Radical Scavengers; Histidine; L-Lactate Dehydrogenase; Lipopolysaccharides; Mammary Glands, Animal; Molsidomine; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidants; Peroxidase; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine

2001
SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay).
    Free radical biology & medicine, 2001, Mar-15, Volume: 30, Issue:6

    Topics: Ascorbic Acid; Calcium; Catalase; Chelating Agents; Comet Assay; Data Interpretation, Statistical; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Egtazic Acid; Flow Cytometry; Humans; Kinetics; Lymphocytes; Microscopy, Ultraviolet; Molsidomine; Nitrates; Nitric Oxide Donors; Superoxide Dismutase

2001
Effects of nitric oxide on normal and ischemic cochlea of the guinea pig.
    Experimental neurology, 2001, Volume: 169, Issue:1

    Topics: Animals; Catalase; Cell Count; Cochlea; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Ischemia; Microinjections; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Nitroglycerin; Nitroso Compounds; Perilymph; S-Nitrosothiols; Sensory Receptor Cells; Superoxide Dismutase

2001
A redox-based mechanism for the contractile and relaxing effects of NO in the guinea-pig gall bladder.
    The Journal of physiology, 2001, May-01, Volume: 532, Issue:Pt 3

    Topics: Acetylcholine; Animals; Arachidonic Acid; Atropine; Calcium; Gallbladder; Guinea Pigs; Male; Molsidomine; Muscle Contraction; Muscle, Smooth; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; Parasympatholytics; Vasodilator Agents

2001
Peroxynitrite inhibits inducible (type 2) nitric oxide synthase in murine lung epithelial cells in vitro.
    Free radical biology & medicine, 2001, May-01, Volume: 30, Issue:9

    Topics: Animals; Base Sequence; Cell Line; DNA Primers; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Hydrazines; Lung; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; RNA, Messenger; Tyrosine

2001
Hepatocellular oxidative DNA injury induced by macrophage-derived nitric oxide.
    Free radical biology & medicine, 2001, May-01, Volume: 30, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; DNA Damage; Enzyme Inhibitors; Free Radicals; Hepatocytes; In Vitro Techniques; Interferon-gamma; Lipopolysaccharides; Macrophages; Male; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Rats, Wistar; Recombinant Proteins; Superoxide Dismutase

2001
Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor.
    The Journal of biological chemistry, 2001, Jul-06, Volume: 276, Issue:27

    Topics: Aldehydes; Apolipoprotein A-I; Aryldialkylphosphatase; Electrophoresis, Polyacrylamide Gel; Esterases; Humans; Hydrolysis; Lipoproteins, HDL; Lysophosphatidylcholines; Molsidomine; Nitrates; Oxidation-Reduction; Phosphatidylcholines; Phospholipases A; Proteolipids; Trypsin

2001
Nitrogen dioxide induces death in lung epithelial cells in a density-dependent manner.
    American journal of respiratory cell and molecular biology, 2001, Volume: 24, Issue:5

    Topics: Cell Count; Cell Death; Cells, Cultured; Culture Media, Conditioned; DNA, Single-Stranded; In Situ Nick-End Labeling; Lung; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrites; Nitrogen Dioxide; Oxidative Stress; Respiratory Mucosa

2001
In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation.
    Blood, 2001, Jun-01, Volume: 97, Issue:11

    Topics: Annexin A5; Apoptosis; Cells, Cultured; Child, Preschool; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; In Situ Nick-End Labeling; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stromal Cells; Superoxide Dismutase; Superoxides; T-Lymphocytes; Thymus Gland; Tyrosine

2001
Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein.
    Carcinogenesis, 2001, Volume: 22, Issue:6

    Topics: Acrolein; Amidines; Animals; Antioxidants; Benzo(a)pyrene; Biotransformation; Cell Transformation, Neoplastic; Fibroblasts; Free Radicals; Lipid Peroxidation; Mice; Mice, Inbred C3H; Molsidomine; Mutagens; Nitrates; Nitric Oxide Donors; Oxidants; Oxidative Stress; Reactive Oxygen Species; Vitamin E

2001
Immunostimulation of rat primary astrocytes decreases intracellular ATP level.
    Brain research, 2001, Jun-01, Volume: 902, Issue:2

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Central Nervous System; Dose-Response Relationship, Drug; Encephalitis; Enzyme Inhibitors; Inflammation Mediators; Interferon-gamma; Intracellular Fluid; L-Lactate Dehydrogenase; Lipopolysaccharides; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Tumor Cells, Cultured

2001
Two different NO-dependent mechanisms account for the low virulence of a non-mycelial morphological mutant of Candida albicans.
    Medical microbiology and immunology, 2001, Volume: 189, Issue:3

    Topics: Animals; Candida albicans; Candidiasis; Guanidines; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Molsidomine; Mutagenesis; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Virulence

2001
Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution.
    Biochemistry, 2001, Jun-26, Volume: 40, Issue:25

    Topics: Bicarbonates; Cyclic N-Oxides; Free Radicals; Hydroxyl Radical; Lipid Bilayers; Liposomes; Mass Spectrometry; Membranes, Artificial; Molsidomine; Nitrates; Nitrosation; Oxidation-Reduction; Solutions; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spin Labels; Tyrosine; Water

2001
Effects of nitric oxide and peroxynitrite on endotoxin-induced leukocyte adhesion to endothelium.
    Journal of cellular physiology, 2001, Volume: 188, Issue:3

    Topics: Animals; Cattle; Cell Adhesion; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Interferon-gamma; Leukocytes; Lipopolysaccharides; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Triazenes

2001
Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production.
    British journal of pharmacology, 2001, Volume: 133, Issue:7

    Topics: Blotting, Northern; Blotting, Western; Cell Line; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Molsidomine; Nitrates; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha

2001
Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stress.
    Biochemical and biophysical research communications, 2001, Aug-17, Volume: 286, Issue:2

    Topics: Biomarkers; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Molsidomine; Mutagenesis, Site-Directed; Myocardial Reperfusion Injury; Myoglobin; Nitrates; Oxidative Stress; Reactive Oxygen Species

2001
Peroxynitrite causes endothelial cell monolayer barrier dysfunction.
    American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:3

    Topics: Actins; Animals; beta Catenin; Cell Survival; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Pulmonary Artery; Reactive Oxygen Species; Superoxide Dismutase; Swine; Trans-Activators; Tyrosine

2001
Role of nitric oxide in histamine release from human basophils and rat peritoneal mast cells.
    European journal of pharmacology, 2001, Aug-17, Volume: 425, Issue:3

    Topics: Animals; Antibodies; Arginine; Basophils; Calcimycin; Dose-Response Relationship, Drug; Guanidines; Hemoglobins; Histamine; Humans; Immunoglobulin E; Male; Mast Cells; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Sodium Nitrite

2001
Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants.
    Molecular pharmacology, 2001, Volume: 60, Issue:4

    Topics: Acetates; Acetylcholine; Animals; Antioxidants; Biological Transport; Carbon Radioisotopes; Choline; Choline O-Acetyltransferase; Drug Interactions; Molsidomine; Nitrates; Oxidants; Reducing Agents; Torpedo; Tyrosine; Uric Acid

2001
[Erectile dysfunction. Help also for cardiac patients].
    MMW Fortschritte der Medizin, 2001, Oct-11, Volume: 143, Issue:41

    Topics: Apomorphine; Contraindications; Coronary Disease; Drug Interactions; Erectile Dysfunction; Humans; Male; Molsidomine; Nitrates; Piperazines; Purines; Sildenafil Citrate; Sulfones

2001
Formation of peroxynitrite from reaction of nitroxyl anion with molecular oxygen.
    The Journal of biological chemistry, 2002, Apr-19, Volume: 277, Issue:16

    Topics: Animals; Anions; Antioxidants; Cattle; Dose-Response Relationship, Drug; Hydrogen Peroxide; Hydrogen-Ion Concentration; Models, Chemical; Molsidomine; NAD; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitrogen Oxides; Oxygen; Peroxynitrous Acid; Rhodamines; Superoxide Dismutase

2002
Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:2

    Topics: Alginates; Apoptosis; Cell Survival; Cells, Cultured; Chondrocytes; Humans; Microspheres; Molsidomine; NAD; NADP; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroprusside; Nitroso Compounds; Oxidative Stress; Reactive Oxygen Species; Triazenes

2002
Peroxynitrite scavenging activity of sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) isolated from Brassica juncea.
    Journal of agricultural and food chemistry, 2002, Oct-09, Volume: 50, Issue:21

    Topics: Brassica; Coumaric Acids; Free Radical Scavengers; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxides; Tyrosine

2002
Nitric oxide and peroxynitrite promote complete disruption of the [4Fe-4S] cluster of recombinant human iron regulatory protein 1.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2003, Volume: 8, Issue:1-2

    Topics: Aconitate Hydratase; Blotting, Western; Conserved Sequence; Electrophoretic Mobility Shift Assay; Ferrozine; Humans; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Mercaptoethanol; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Tyrosine

2003
Indirect measurement of nitric oxide production by monitoring nitrate and nitrite using microchip electrophoresis with electrochemical detection.
    Analytical chemistry, 2002, Dec-15, Volume: 74, Issue:24

    Topics: Electrochemistry; Electrophoresis; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Reproducibility of Results; Sensitivity and Specificity

2002
Three model systems measure oxidation/nitration damage caused by peroxynitrite.
    Journal of biosciences, 2003, Volume: 28, Issue:1

    Topics: Antioxidants; DNA Damage; DNA, Superhelical; Escherichia coli; Fruit; Luciferases; Luminescent Measurements; Luminol; Molsidomine; Mutation; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Phenols; Plasmids; Solutions; Tea

2003
NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis.
    Kidney international, 2003, Volume: 64, Issue:2

    Topics: Animals; Arginine; Blood Pressure; Body Weight; Enzyme Inhibitors; Fibronectins; Fibrosis; Gene Expression; Glomerulonephritis; Isoantibodies; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Plasminogen Activator Inhibitor 1; Proteinuria; Rats; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1

2003
Human plasminogen is highly susceptible to peroxynitrite inactivation.
    Clinical chemistry and laboratory medicine, 2003, Volume: 41, Issue:8

    Topics: Antithrombin III; Chromogenic Compounds; Data Interpretation, Statistical; Diabetes Mellitus; Drug Combinations; Enzyme Inhibitors; Fructose; Glucose; Humans; Molsidomine; Nitrates; Oxidants; Plasma; Plasminogen; Streptokinase

2003
Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.
    Biochemical and biophysical research communications, 2004, Jul-30, Volume: 320, Issue:3

    Topics: 3T3-L1 Cells; Animals; Binding Sites; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Molsidomine; Nitrates; Peroxynitrous Acid; Phosphoproteins; Protein Binding; Rats; Tyrosine

2004
Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2005, Volume: 289, Issue:3

    Topics: Animals; Blood Pressure; Hemodynamics; Hypertension; Kidney; Male; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrites; Oxidative Stress; Oxidoreductases; Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Superoxides; Tyrosine

2005
Peroxynitrite-mediated matrix metalloproteinase-2 activation in human hepatic stellate cells.
    FEBS letters, 2005, Jun-06, Volume: 579, Issue:14

    Topics: Cell Line; Collagenases; Enzyme Activation; Hepatocytes; Humans; I-kappa B Proteins; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Molsidomine; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrates; Penicillamine; Peroxynitrous Acid; Phosphorylation; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1

2005
Angiotensin II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells.
    FEBS letters, 2005, Sep-12, Volume: 579, Issue:22

    Topics: Angiotensin II; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Rats; Receptor, Angiotensin, Type 1; Tyrosine

2005
Nitric oxide and peroxynitrite regulate transporter transcription in rat liver slices.
    Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:10

    Topics: Animals; Aspartate Aminotransferases; Carrier Proteins; Gadolinium; In Vitro Techniques; Interleukin-1beta; Liver; Male; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spermine; Transcription, Genetic; Tumor Necrosis Factor-alpha

2008
Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.
    Chemical & pharmaceutical bulletin, 2008, Volume: 56, Issue:12

    Topics: Animals; Antioxidants; Brain Chemistry; Cell Survival; Indicators and Reagents; Indole Alkaloids; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; PC12 Cells; Peroxynitrous Acid; Piperazines; Protective Agents; Rats; Structure-Activity Relationship; Tyrosine

2008
Elevated plasma concentration of NO and cGMP may be responsible for the decreased platelet aggregation and platelet leukocyte conjugation in platelets hypo-responsive to catecholamines.
    Platelets, 2009, Volume: 20, Issue:8

    Topics: Adenosine Triphosphate; Adult; Asian People; Blood Platelets; Catecholamines; Cyclic AMP; Cyclic GMP; Female; Humans; Leukocyte Common Antigens; Leukocytes; Male; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Platelet Aggregation; Platelet Aggregation Inhibitors; Young Adult

2009
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion.
    European journal of pharmacology, 2010, Feb-10, Volume: 627, Issue:1-3

    Topics: Blood Platelets; Blood Proteins; Cell Adhesion; Enzyme Inhibitors; Fibrinogen; Free Radical Scavengers; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Peroxynitrous Acid; Solubility; Superoxides; Thrombin; Tyrosine

2010
Refractory blood pressure in female SHR to increased oxidative stress is not mediated by NO or by upregulation of renal antioxidant enzymes.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 298, Issue:2

    Topics: Animals; Antioxidants; Blood Pressure; Female; Hypertension; Isoprostanes; Kidney; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Up-Regulation; Vasodilator Agents

2010
Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration.
    Journal of neurochemistry, 2010, Volume: 113, Issue:2

    Topics: Animals; Caspase 3; Cell Count; Cell Death; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; Metalloporphyrins; Mice; Molsidomine; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Nitrates; Oxidative Stress; Oxidopamine; Porphyrins; Sympatholytics

2010
A dual acting compound with latanoprost amide and nitric oxide releasing properties, shows ocular hypotensive effects in rabbits and dogs.
    Experimental eye research, 2011, Volume: 93, Issue:3

    Topics: Amides; Animals; Antihypertensive Agents; Aorta; Bimatoprost; Chromatography, High Pressure Liquid; Cloprostenol; Dinoprost; Disease Models, Animal; Dogs; Glaucoma; Intraocular Pressure; Latanoprost; Male; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Ocular Hypertension; Prostaglandins F, Synthetic; Rabbits; Tandem Mass Spectrometry; Tonometry, Ocular; Vasodilation; Vasodilator Agents

2011
[From beta blocker to relaxation exercises. Prevention of angina pectoris attacks].
    MMW Fortschritte der Medizin, 2011, Feb-24, Volume: 153, Issue:8

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Exercise Therapy; Humans; Molsidomine; Nitrates; Relaxation Therapy

2011
Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.
    Experimental neurology, 2012, Volume: 233, Issue:1

    Topics: Antioxidants; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Humans; Imidazolidines; Male; MAP Kinase Signaling System; Membrane Glycoproteins; Membrane Transport Proteins; Molsidomine; Nitrates; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroprusside; Nitrosation; RNA, Messenger; Schwann Cells; Taurine; Thioctic Acid

2012