nitrates and alpha-synuclein

nitrates has been researched along with alpha-synuclein in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's20 (71.43)29.6817
2010's4 (14.29)24.3611
2020's4 (14.29)2.80

Authors

AuthorsStudies
Chen, Q; Giasson, BI; Ischiropoulos, H; Lee, VM; Souza, JM1
Chen, Q; Duda, JE; Giasson, BI; Gollomp, SM; Gur, TL; Hurtig, HI; Ischiropoulos, H; Lee, VM; Stern, MB; Trojanowski, JQ1
Chen, Q; Giasson, BI; Ischiropoulos, H; Lee, VM; Norris, EH; Paxinou, E; Rueter, SM; Trojanowski, JQ; Weisse, M1
García Yébenes, J; Gómez-Tortosa, E; Gonzalo, I; Hyman, BT; Newell, K; Vonsattel, P1
Nagano, Y; Nakamura, S; Nakamura, T; Takahashi, T; Yamashita, H1
Duda, JE; Giasson, BI; Lee, VM; Mabon, ME; Trojanowski, JQ1
Drazba, J; Gaivin, R; Gonzalez-Cabrera, P; McCune, DF; Papay, R; Perez, DM; Ross, SA; Yun, J; Zuscik, MJ1
Ischiropoulos, H1
Giasson, BI; Ischiropoulos, H; Lee, VM; Norris, EH1
Halliwell, B; Hyun, DH; Jenner, P; Lee, M1
Giasson, BI; Hodara, R; Ischiropoulos, H; Lee, VM; Lynch, DR; Mishizen-Eberz, AJ; Norris, EH1
Giasson, BI; Hodara, R; Ischiropoulos, H; Lee, VM; Lynch, DR; Mishizen-Eberz, AJ; Norris, EH; Trojanowski, JQ1
Blair, IA; Hodara, R; Ischiropoulos, H; Lind, S; Oe, T; Rubbo, H; Souza, JM; Trostchansky, A1
Combs, CK; Ebadi, M; Shavali, S1
Rubbo, H; Trostchansky, A1
Berry, RW; Binder, LI; Reynolds, MR1
Banerjee, R; Benner, EJ; Ciborowski, P; Gendelman, HE; Mosley, RL; Nemachek, C; Pisarev, VM; Przedborski, S; Reynolds, AD; Sherman, S; Tsiperson, V1
Banerjee, R; Ciborowski, P; Garg, SK; Gendelman, HE; Glanzer, JG; Kadiu, I; Nordgren, T; Reynolds, AD1
Adame, A; Inglis, C; Lee, PH; Mante, M; Masliah, E; Rockenstein, E; Stefanova, N; Ubhi, K; Wenning, GK1
Andersen, JK; Danielson, SR; Gibson, BW; Held, JM; Oo, M; Schilling, B1
He, C; Hu, C; Xiang, Z; Xu, X; Yu, Z; Zhang, Z; Zhou, J1
Dunn, JM; Rhoades, E; Sevcsik, E; Trexler, AJ1
de Oliveira, RM; Klucken, J; Outeiro, TF; Penque, D; Pimentel, J; Simões, T; Vicente Miranda, H; Xiang, W1
Ait-Bouziad, N; Burai, R; Chiki, A; Lashuel, HA1
Hegemann, JD; Liu, L; Long, T; Quan, J; Tao, Y; Tian, H; Uesugi, M; Wang, H; Yao, W; Zhang, W; Zheng, J1
Chen, H; Chen, J; Chen, Q; Hu, J; Hu, X; Koh, K; Xu, XH; Zhang, ZH1
Chen, H; Chen, J; Chen, Q; Hu, R; Hu, X; Liu, Y; Lu, Y; Zhu, H1
Chen, H; Chen, J; Hu, R; Hu, X; Xu, X; Zhang, Y; Zhang, Z1

Reviews

3 review(s) available for nitrates and alpha-synuclein

ArticleYear
Oxidative modifications of alpha-synuclein.
    Annals of the New York Academy of Sciences, 2003, Volume: 991

    Topics: alpha-Synuclein; Animals; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitrates; Oxidative Stress; Protein Processing, Post-Translational; Synucleins

2003
Lipid nitration and formation of lipid-protein adducts: biological insights.
    Amino acids, 2007, Volume: 32, Issue:4

    Topics: alpha-Synuclein; Humans; Lipid Metabolism; Lipids; Lipoproteins, LDL; Nitrates; Oxidative Stress; Proteins; Reactive Nitrogen Species; Tyrosine

2007
Nitration in neurodegeneration: deciphering the "Hows" "nYs".
    Biochemistry, 2007, Jun-26, Volume: 46, Issue:25

    Topics: alpha-Synuclein; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Humans; Nitrates; Parkinson Disease; Protein Processing, Post-Translational; Superoxide Dismutase; tau Proteins; Tyrosine 3-Monooxygenase

2007

Other Studies

25 other study(ies) available for nitrates and alpha-synuclein

ArticleYear
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies.
    The Journal of biological chemistry, 2000, Jun-16, Volume: 275, Issue:24

    Topics: alpha-Synuclein; Electrophoresis, Polyacrylamide Gel; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitrates; Oxidative Stress; Polymers; Recombinant Proteins; Synucleins; Tyrosine

2000
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
    The American journal of pathology, 2000, Volume: 157, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Antibodies; Blotting, Western; Brain Diseases; Female; Humans; Immunohistochemistry; Inclusion Bodies; Lewy Bodies; Male; Middle Aged; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroglia; Nitrates; Synucleins; Tissue Distribution; Tyrosine

2000
Induction of alpha-synuclein aggregation by intracellular nitrative insult.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Oct-15, Volume: 21, Issue:20

    Topics: alpha-Synuclein; Ammonium Chloride; beta-Synuclein; Cell Line; Cysteine Endopeptidases; Enzyme Inhibitors; Humans; Inclusion Bodies; Intracellular Fluid; Kidney; Lysosomes; Macromolecular Substances; Multienzyme Complexes; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitrates; Nitric Oxide; Oxidants; Proteasome Endopeptidase Complex; Protein Binding; Superoxides; Synucleins; Transfection; Ubiquitins

2001
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.
    Acta neuropathologica, 2002, Volume: 103, Issue:5

    Topics: Aged; alpha-Synuclein; Brain; Cell Nucleus; Female; Humans; Inclusion Bodies; Lewy Bodies; Lewy Body Disease; Male; Middle Aged; Nerve Tissue Proteins; Neurites; Neuroglia; Neurons; Nitrates; Oxidative Stress; Striatonigral Degeneration; Synucleins; Tyrosine

2002
Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress.
    Brain research, 2002, May-31, Volume: 938, Issue:1-2

    Topics: alpha-Synuclein; Dimerization; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; In Vitro Techniques; Microscopy, Confocal; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Synucleins; Tyrosine

2002
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.
    Annals of neurology, 2002, Volume: 52, Issue:2

    Topics: alpha-Synuclein; Antibodies, Monoclonal; Corpus Striatum; Humans; Lewy Body Disease; Molecular Weight; Nerve Tissue Proteins; Nitrates; Peptide Fragments; Synucleins

2002
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.
    Journal of neurochemistry, 2002, Volume: 83, Issue:3

    Topics: Adrenergic alpha-Antagonists; alpha-Synuclein; Animals; Body Weight; Brain; Cerebellum; Disease Models, Animal; Female; Inclusion Bodies; Macromolecular Substances; Male; Mice; Mice, Transgenic; Motor Activity; Multiple System Atrophy; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nitrates; Oligodendroglia; Phosphorylation; Prazosin; Receptors, Adrenergic, alpha-1; Spinal Cord; Survival Rate; Synucleins; Tyrosine; Ubiquitin

2002
Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.
    The Journal of biological chemistry, 2003, Jul-18, Volume: 278, Issue:29

    Topics: alpha-Synuclein; Cell Line; Cross-Linking Reagents; Drug Stability; Humans; In Vitro Techniques; Inclusion Bodies; Microscopy, Electron; Models, Biological; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Nitrates; Oxidation-Reduction; Oxidative Stress; Protein Processing, Post-Translational; Protein Structure, Quaternary; Recombinant Proteins; Synucleins; Tyrosine

2003
Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins.
    Journal of neurochemistry, 2003, Volume: 86, Issue:2

    Topics: Acetylcysteine; alpha-Synuclein; Cell Line; Cell Survival; Cysteine Endopeptidases; Enzyme Inhibitors; Gene Transfer Techniques; Humans; Ligases; Macromolecular Substances; Multienzyme Complexes; Nerve Tissue Proteins; Neurofilament Proteins; Nitrates; Nitric Oxide Synthase; Proteasome Endopeptidase Complex; Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Synucleins; Tubulin; Ubiquitin; Ubiquitin-Protein Ligases

2003
Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.
    The Journal of biological chemistry, 2004, Nov-12, Volume: 279, Issue:46

    Topics: alpha-Synuclein; Animals; Calpain; Humans; Insulin; Lipid Metabolism; Mice; Molecular Chaperones; Nerve Tissue Proteins; Nitrates; Oxygen; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Quaternary; Synucleins; Tyrosine

2004
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
    Biochemistry, 2005, May-31, Volume: 44, Issue:21

    Topics: alpha-Synuclein; Calpain; Chymotrypsin; Humans; Hydrolysis; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Parkinson Disease; Peptide Fragments; Peroxynitrous Acid; Recombinant Proteins; Solubility; Synucleins; Tyrosine

2005
Interaction with phospholipids modulates alpha-synuclein nitration and lipid-protein adduct formation.
    The Biochemical journal, 2006, Jan-01, Volume: 393, Issue:Pt 1

    Topics: Aldehydes; alpha-Synuclein; Gene Expression Regulation; Humans; Lipid Peroxidation; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Phospholipids

2006
Reactive macrophages increase oxidative stress and alpha-synuclein nitration during death of dopaminergic neuronal cells in co-culture: relevance to Parkinson's disease.
    Neurochemical research, 2006, Volume: 31, Issue:1

    Topics: alpha-Synuclein; Animals; Cells, Cultured; Coculture Techniques; Dopamine; Humans; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Microglia; Neurons; Nitrates; Nitric Oxide; Oxidative Stress; Parkinson Disease; Peroxynitrous Acid; Tetrahydroisoquinolines

2006
Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.
    PloS one, 2008, Jan-02, Volume: 3, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adoptive Transfer; alpha-Synuclein; Animals; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epitopes; Flow Cytometry; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Nitrates; Substantia Nigra

2008
Nitrated alpha-synuclein and microglial neuroregulatory activities.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2008, Volume: 3, Issue:2

    Topics: alpha-Synuclein; Animals; Cathepsin B; Cells, Cultured; Cystatins; Cysteine; Cytoskeletal Proteins; Dopamine; Gene Expression Regulation; Glutamic Acid; Glutathione; Mice; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; NF-kappa B; Nitrates; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Array Analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry

2008
Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy.
    Journal of neuroscience research, 2009, Volume: 87, Issue:12

    Topics: alpha-Synuclein; Animals; Brain; Convulsants; Disease Models, Animal; Mice; Mice, Transgenic; Mitochondria; Multiple System Atrophy; Myelin Basic Protein; Nerve Degeneration; Nitrates; Nitro Compounds; Oxidative Stress; Promoter Regions, Genetic; Propionates

2009
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.
    Analytical chemistry, 2009, Sep-15, Volume: 81, Issue:18

    Topics: alpha-Synuclein; Animals; Lewy Bodies; Mass Spectrometry; Models, Biological; Monoamine Oxidase; Nitrates; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Tyrosine

2009
Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats.
    PloS one, 2010, Apr-08, Volume: 5, Issue:4

    Topics: alpha-Synuclein; Animals; Cell Death; Cells, Cultured; Dopamine; Down-Regulation; Gait Disorders, Neurologic; Neurons; Nitrates; Parkinson Disease; Rats; Receptors, Dopamine D2; Substantia Nigra

2010
Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding.
    Journal of the American Chemical Society, 2011, May-11, Volume: 133, Issue:18

    Topics: Allosteric Regulation; alpha-Synuclein; Humans; Hydrodynamics; Lipid Bilayers; Membrane Lipids; Mutation; Nitrates; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Binding; Protein Structure, Secondary; Tyrosine

2011
Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications.
    Journal of neurochemistry, 2013, Volume: 126, Issue:5

    Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Chromatography, Gel; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Hot Temperature; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Phosphorylation; Polymerase Chain Reaction; Protein Processing, Post-Translational; Rats; Rats, Wistar; Saccharomyces cerevisiae; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin

2013
Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.
    Journal of the American Chemical Society, 2015, Apr-22, Volume: 137, Issue:15

    Topics: alpha-Synuclein; Humans; Molecular Structure; Mutagenesis; Nitrates; Parkinson Disease; Protein Processing, Post-Translational

2015
Light-Controlled Tyrosine Nitration of Proteins.
    Angewandte Chemie (International ed. in English), 2021, 06-07, Volume: 60, Issue:24

    Topics: alpha-Synuclein; Animals; Light; Mice; Nitrates; Oxidation-Reduction; Tumor Necrosis Factor-alpha; Tyrosine

2021
The magnetic-nanoparticle-assisted sensitive detection of nitrated α-syn in blood based on a sensitizing electrochemical layer.
    Nanoscale, 2021, May-06, Volume: 13, Issue:17

    Topics: alpha-Synuclein; Biosensing Techniques; Electrochemical Techniques; Gold; Humans; Immunoassay; Limit of Detection; Magnetic Phenomena; Metal Nanoparticles; Neurodegenerative Diseases; Nitrates

2021
Nanozyme-based cascade SPR signal amplification for immunosensing of nitrated alpha-synuclein.
    Mikrochimica acta, 2022, 09-02, Volume: 189, Issue:10

    Topics: alpha-Synuclein; Biomarkers; Biosensing Techniques; Gold; Humans; Immunoassay; Metal Nanoparticles; Nitrates; Parkinson Disease; Surface Plasmon Resonance

2022
A dual-modality immunosensor for simple and reliable detection of nitrated alpha-synuclein in serum based on silver-coated MOF.
    Mikrochimica acta, 2023, 04-29, Volume: 190, Issue:5

    Topics: alpha-Synuclein; Biosensing Techniques; Humans; Immunoassay; Metal Nanoparticles; Metal-Organic Frameworks; Nitrates; Oxidoreductases; Silver

2023