Compounds > nitracrine
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nitracrine and 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine

nitracrine has been researched along with 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's6 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ashok, BT; Banerjee, D; Iatropoulos, M; Konopa, J; Tadi, K; Tiwari, RK1
Ashok, BT; Banerjee, D; Chen, Y; Garikapaty, VP; Huang, Q; Konopa, J; Tadi, K; Tiwari, RK1
Ashok, BT; Banerjee, D; Chen, Y; Darzynkiewicz, Z; Konopa, J; Tadi, K; Tiwari, RK; Wysocka-Skrzela, B1
Augustin, E; Konopa, J; Moś-Rompa, A; Nowak-Ziatyk, D1
Augustin, E; Henderson, C; Jagiełło, K; Konopa, J; Mazerska, Z; Niemira, M; Potęga, A; Skwarska, A; Swist, M; Wiśniewska, A1
Dastych, J; Mazerska, Z; Niemira, M1
Augustin, E; Hołownia, A; Mazerska, Z; Niemira, M1
Augustin, E; Borowa-Mazgaj, B; Mazerska, Z; Mróz, A; Paluszkiewicz, E1
Bejrowska, A; Mazerska, Z; Mróz, A; Ryska, I; Sominko, H1

Other Studies

9 other study(ies) available for nitracrine and 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine

ArticleYear
Pre-clinical toxicology and pathology of 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), a novel anti-cancer agent in male Beagle dogs.
    Life sciences, 2006, Aug-29, Volume: 79, Issue:14

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bile Ducts; Blood Cell Count; Body Weight; Dogs; Injections, Intravenous; Kidney Function Tests; Leukopenia; Liver Function Tests; Lymph Nodes; Male; Myocardium; Nitracrine; Thrombocytopenia; Vomiting; Water-Electrolyte Balance

2006
Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents.
    Anti-cancer drugs, 2007, Volume: 18, Issue:1

    Topics: Animals; Blood; DNA, Neoplasm; Injections, Intraperitoneal; Injections, Intravenous; Kidney; Lethal Dose 50; Liver; Male; Mice; Mice, Inbred BALB C; Nitracrine; Nucleic Acid Hybridization; Prostatic Neoplasms; Rats

2007
Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer.
    Cancer biology & therapy, 2007, Volume: 6, Issue:10

    Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Line, Tumor; Down-Regulation; Drug Evaluation, Preclinical; Histones; Humans; Intercalating Agents; Male; Mice; Mice, Inbred BALB C; Nitracrine; Prostatic Neoplasms; Xenograft Model Antitumor Assays

2007
Antitumor 1-nitroacridine derivative C-1748, induces apoptosis, necrosis or senescence in human colon carcinoma HCT8 and HT29 cells.
    Biochemical pharmacology, 2010, May-01, Volume: 79, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Molecular Structure; Necrosis; Nitracrine

2010
Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells.
    Biochemical pharmacology, 2012, Jul-01, Volume: 84, Issue:1

    Topics: Aminoacridines; Animals; Antineoplastic Agents; Biotransformation; Cell Culture Techniques; Cell Hypoxia; Chromatography, High Pressure Liquid; Hep G2 Cells; Humans; Male; Mice; Mice, Knockout; Microsomes, Liver; Molecular Structure; NADPH-Ferrihemoprotein Reductase; Nitracrine; Rats; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship

2012
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.
    Biochemical pharmacology, 2013, Jul-15, Volume: 86, Issue:2

    Topics: Acridines; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; DNA Primers; Hep G2 Cells; Humans; Hypoxia; Nitracrine; Pregnane X Receptor; Real-Time Polymerase Chain Reaction; Receptors, Steroid; Triazoles; Up-Regulation

2013
CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells.
    Cell biology international, 2014, Volume: 38, Issue:11

    Topics: Acridines; Antineoplastic Agents; Biocatalysis; Cell Cycle Checkpoints; Cell Survival; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Hep G2 Cells; Humans; Mass Spectrometry; Nitracrine; Triazoles

2014
The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748.
    Biochemical pharmacology, 2017, 10-15, Volume: 142

    Topics: Antineoplastic Agents; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP3A; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression; Humans; Membrane Potential, Mitochondrial; NADPH-Ferrihemoprotein Reductase; Nitracrine; Pancreatic Neoplasms; Transfection; Up-Regulation

2017
Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:5

    Topics: Animals; Biotransformation; Cell Line, Tumor; Glucuronosyltransferase; Humans; Microsomes, Liver; Nitracrine; Rats; UDP-Glucuronosyltransferase 1A9

2018