nitinol and gadofosveset-trisodium

In magnetic resonance imaging, implantable devices are usually visualized with a negative contrast. Recently, positive contrast techniques have been proposed, such as susceptibility gradient mapping (SGM). However, SGM reduces the spatial resolution making positive visualization of small structures difficult. Here, a development of SGM using the original resolution (SUMO) is presented. For this, a filter is applied in k-space and the signal amplitude is analyzed in the image domain to determine quantitatively the susceptibility gradient for each pixel. It is shown in simulations and experiments that SUMO results in a better visualization of small structures in comparison to SGM. SUMO is applied to patient datasets for visualization of stent and prostate brachytherapy seeds. In addition, SUMO also provides quantitative information about the number of prostate brachytherapy seeds. The method might be extended to application for visualization of other interventional devices, and, like SGM, it might also be used to visualize magnetically labelled cells.

Topics: Alloys; Aortic Aneurysm, Thoracic; Aortic Dissection; Brachytherapy; Computer Simulation; Gadolinium; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Models, Theoretical; Organometallic Compounds; Phantoms, Imaging; Prostatic Neoplasms; Software; Stents